ライフサイエンスコーパス: linkage analysis

1 from the same family and was integrated with linkage analysis.

2 We genotyped the mice and performed linkage analysis.

3 ased model to perform variant and gene-based linkage analysis.

4 SCA-affected Italian family by whole-genome linkage analysis.

5 us on chromosome 2p11.1-q12.2 by genome-wide linkage analysis.

6 memory performance were used for genome-wide linkage analysis.

7 ty in this family using exome sequencing and linkage analysis.

8 ring contigs into pseudomolecules by genetic linkage analysis.

9 ding programs and has been mainly studied by linkage analysis.

10 pG ODN defect, we have performed genome-wide linkage analysis.

11 a causal RBM20 mutation without the need for linkage analysis.

12 ofiling, sulphate content determination, and linkage analysis.

13 on a 0.3-Mb region of mouse chromosome 4 by linkage analysis.

14 ly inherited traits otherwise intractable by linkage analysis.

15 portant data sources for mapping QTL through linkage analysis.

16 the rgt mutants were elucidated by glycosyl linkage analysis.

17 implicated in essential hypertension by gene linkage analysis.

18 onstrating its potential for oligosaccharide linkage analysis.

19 lized along with disease status in bivariate linkage analysis.

20 design, the authors conducted nonparametric linkage analysis.

21 nd reduced digests that facilitate disulfide linkage analysis.

22 BD) probabilities is the key in family-based linkage analysis.

23 were used to select high-quality markers for linkage analysis.

24 pported as the causal mutation by parametric linkage analysis.

25 A founder effect was excluded by linkage analysis.

26 f common CD-associated risk variants and for linkage analysis.

27 cleft lip and/or palate through genome-wide linkage analysis.

28 e 2H on chromosome 8q13-21.1 was excluded by linkage analysis.

29 e glycotope were based on mass spectrometry, linkage analysis, (1)H nuclear magnetic resonance spectr

30 whereby QTL were detected using a sire-based linkage analysis, a sparse SNP marker map and exploiting

31 riants were found at both loci identified by linkage analysis: a homozygous stop codon in PI3-kinase

32 onal statistical genetics approaches such as linkage analysis and association studies have limited po

33 We performed genetic linkage analysis and candidate gene sequencing on 13 pat

34 Linkage analysis and complementation tests showed that t

35 candidate mutations, which were narrowed by linkage analysis and confirmed by Sanger sequencing and

36 with calf weakness, we identified by genetic linkage analysis and exome sequencing a heterozygous mis

37 The combined linkage analysis and exome sequencing in the index famil

38 We used linkage analysis and exome sequencing of a multiplex fam

39 Whole-genome linkage analysis and exome sequencing of distant relativ

40 We used linkage analysis and exome sequencing to identify the ca

41 Genome-wide linkage analysis and exome sequencing were performed in

42 By linkage analysis and exome sequencing, we identified a p

43 Using genome-wide linkage analysis and exome sequencing, we identified hom

44 By linkage analysis and exome sequencing, we unexpectedly i

45 Pakistani families, we performed genome-wide linkage analysis and fine mapping and identified linkage

46 Using linkage analysis and fine mapping, we identified the dis

47 We used non-parametric linkage analysis and genome sequencing to identify a bia

48 soriasis, for which application of classical linkage analysis and genome-wide association investigati

49 guineous family with five affected siblings, linkage analysis and genomic sequencing revealed the gen

50 Linkage analysis and homozygosity mapping combined with

51 GWAS, linkage analysis and homozygosity mapping defined a 26-M

52 relevant genes and complementing traditional linkage analysis and homozygosity mapping.

53 ications such as de novo mutation detection, linkage analysis and lineage tracing.

54 Here we have performed genetic linkage analysis and mapped the disease locus to 1p13.3-

55 We applied genetic linkage analysis and next-generation sequencing and func

56 mined the individual genotypes by SNPlex for linkage analysis and parental transmission disequilibriu

57 esis-independent genetic studies of CRS (ie, linkage analysis and pooling-based genome-wide associati

58 Here, we review the principles of linkage analysis and provide practical guidelines for ca

59 ich is not used by current methodologies for linkage analysis and QTL mapping.

60 Linkage analysis and sequencing were performed in multig

61 Here we used linkage analysis and targeted deep sequencing to detect

62 Further evaluation of one group by linkage analysis and targeted sequencing identified rece

63 ci associated with 49 DCPs were confirmed by linkage analysis and tests of genetically modified paras

64 an unbiased genome-wide approach using both linkage analysis and variant filtering across the exome

65 We have demonstrated that a combination of linkage analysis and whole exome sequencing can be used

66 Linkage analysis and whole exome sequencing revealed a h

67 Linkage analysis and whole exome sequencing were perform

68 Using combined genome-wide linkage analysis and whole-exome sequencing (WES), we id

69 TE-affected families by performing SNP-array linkage analysis and whole-exome sequencing and identifi

70 Linkage analysis and whole-exome sequencing identified a

71 Linkage analysis and whole-exome sequencing identified a

72 We performed genomewide linkage analysis and whole-exome sequencing in a family

73 ions, we identified through a combination of linkage analysis and whole-exome sequencing KCTD17 c.434

74 Using linkage analysis and whole-exome sequencing of DNA sampl

75 Using linkage analysis and whole-exome sequencing on samples f

76 We performed sequential genome-wide linkage analysis and whole-exome sequencing to evaluate

77 We used linkage analysis and whole-exome sequencing to identify

78 Using linkage analysis and whole-exome sequencing, we identifi

79 We used linkage analysis and whole-genome sequencing of a consan

80 We used linkage analysis and whole-genome sequencing of a multip

81 sted to be involved in schizophrenia through linkage analysis, and duplications at 1p36.33 and CGNL1.

82 Genome-wide SNP-typing, linkage analysis, and exome sequencing revealed a homozy

83 By genomic sequencing, linkage analysis, and functional validation, we identifi

84 included incorporation of radiolabeled Glc, linkage analysis, and imaging of cellulose microfibril f

85 AR families are generally too small for linkage analysis, and length of homozygous regions is un

86 cluding monosaccharide analysis, methylation linkage analysis, and mass spectrometry of native LM spe

87 In this study, deep sequencing, genetic linkage analysis, and transcriptome data were used to pr

88 The Utah linkage analysis approach of using singly informative ex

89 Here we describe a global linkage analysis approach, GLINT, for rapid discovery of

90 ative to dystonia, large families suited for linkage analysis are exceptional.

91 We performed linkage analysis, association analysis and haplotype ana

92 Additionally, linkage analysis based on sibling structure within the c

93 We used linkage analysis, based on arrays with single-nucleotide

94 LINK, a novel application that performs MCMC linkage analysis by spreading the computational burden b

95 240 mutation was determined by a genome-wide linkage analysis by use of simple sequence length polymo

96 ton/deuterium exchanges, the composition and linkage analysis can be determined in a single step.

97 traditional gene mapping techniques, such as linkage analysis, can help identify the genetic basis of

98 been identified using four main approaches: linkage analysis, candidate gene sequencing and most rec

99 The primary linkage analysis coded persons with either ASD or specif

100 We utilised a genome-wide marker set for linkage analysis combined with cytological mapping of cr

101 Parametric linkage analysis combined with exome sequencing in a FH4

102 Linkage analysis combined with whole-exome sequencing in

103 A population-based record-linkage analysis compared psychiatric patients with the

104 Here we report a genetic segregation and linkage analysis conducted on F2 progeny of a reciprocal

105 Combining the four families in linkage analysis confirmed a significant genome-wide lin

106 t Xyl levels decreased in uxs3 uxs5 uxs6 and linkage analysis confirmed that the xylan content in uxs

107 Linkage analysis confirmed the region with a logarithm o

108 uage impairment as "affected." The secondary linkage analysis consisted of quantitative metrics of au

109 Linkage analysis defined Quantitative Trait Loci (QTLs)

110 n the year following infection using genetic linkage analysis despite apparently increased risk behav

111 Using whole-exome sequencing, SNPchip-based linkage analysis, DNA microarray, and Sanger sequencing,

112 Genome-wide linkage analysis, DNA sequencing, and an allelic test we

113 enzyme degradation, permethylation glycosyl linkage analysis, electron microscopy, and mutagenesis s

114 d not have been identified using traditional linkage analysis, emphasizing the need for exome sequenc

115 Linkage analysis excluded all variants except a Phe93Leu

116 Methods consisted of genome-wide linkage analysis, exome and Sanger sequencing, clinical

117 In a large Dutch FEVR family, we performed linkage analysis, exome sequencing, and segregation anal

118 Genetic linkage analysis, exome sequencing, tumor studies, and f

119 tic abnormality in this family, we performed linkage analysis followed by whole-exome capture and nex

120 This report confirms that linkage analysis for common disorders can be successful

121 AF4, carbohydrate composition and glycosidic linkage analysis for the dominating population was perfo

122 Genomewide linkage analysis generated one significant LOD score of

123 When used in concert with linkage analysis, haplotyping can help delineate a locus

124 Family-based linkage analysis has been a powerful tool for identifica

125 Genetic linkage analysis has identified loss-of-function mutatio

126 Whole-exome sequencing and linkage analysis have identified 3 hP2X2 receptor mutati

127 By a combination of linkage analysis, homozygosity mapping, and exome sequen

128 Genetic linkage analysis identified 14 loci that were associated

129 Linkage analysis identified 2 disease-associated loci.

130 Joint-linkage analysis identified 32 quantitative trait loci (

131 Homozygosity mapping and linkage analysis identified a candidate region on chromo

132 Linkage analysis identified a peak (LOD = 4.29) on chrom

133 Whole-genome sequencing and linkage analysis identified a variant in a gene that exp

134 Genome wide linkage analysis identified an approximately 18 Mb disea

135 Linkage analysis identified five regions of the genome t

136 Linkage analysis identified potential modifier-gene loci

137 Linkage analysis identified the multi-allelic locus Sen1

138 Genetic linkage analysis identified three loci with an LOD score

139 Comparative genomics and linkage analysis identify candidate genes associated wit

140 We have combined polysaccharide linkage analysis, immuno-labeling, and transcriptome pro

141 s of the remaining cases of DC, we undertook linkage analysis in 20 families and identified a common

142 We thus perform an unbiased linkage analysis in 3A9 TCR F2 (NOD.H2(k) x B10.BR) mice

143 Here we combine whole genome sequencing with linkage analysis in a 3-generation family affected by ca

144 A whole-genome linkage analysis in a Finnish pedigree of eight cases wi

145 Here we use genome-wide linkage analysis in a large ALS/FTD kindred to identify

146 rformed genome-wide expression profiling and linkage analysis in a large F2(DA x PVG) intercross, whi

147 erformed a genome-wide association study and linkage analysis in a sample of 3456 young healthy indiv

148 We conducted a preliminary linkage analysis in a subset of 487 participants with av

149 Using exome sequencing and linkage analysis in a three-generation family with a uni

150 Linkage analysis in a three-generation family with affec

151 We performed genetic linkage analysis in consanguineous families affected by

152 Linkage analysis in F2 intercross (B6 x MSM) progeny ide

153 Whole-genome linkage analysis in five informative families identified

154 Linkage analysis in MF5L6 identified a chromosome 3 locu

155 We performed a genome-wide linkage analysis in patients with cardiac laterality def

156 We carried out a genetic linkage analysis in the extended DYT4 family that spanne

157 Genome-wide linkage analysis in two families identified a 7.5-Mb loc

158 Linkage analysis, including an enantiomeric specific pro

159 Linkage analysis indicated that IDF was composed of homo

160 Linkage analysis indicates that SecA dimerization is cou

161 Nonlinear linkage analysis indicates that this unusual behavior ca

162 xample for the concept that population-based linkage analysis is a useful strategy to identify comple

163 reased use of whole-genome sequencing (WGS), linkage analysis is again emerging as an important and p

164 Linkage analysis is useful in investigating disease tran

165 udies in dogs have primarily employed either linkage analysis, leveraging the typically large family

166 Non-parametric-linkage analysis, linkage-disequilibrium-model analysis,

167 Genetic linkage analysis mapped loci with lod scores of 5 to 7 o

168 METHODS AND Genome-wide linkage analysis mapped the SND+AVB disease locus to chr

169 Linkage analysis mapped this gene on chromosome 5D at in

170 Genome-wide linkage analysis mapped two equally plausible loci to ch

171 sociation methods including mixed models and linkage analysis methods.

172 Genetic analysis included linkage analysis (n = 17) with exome sequencing (n = 7).

173 Using a combination of linkage analysis, next-generation sequencing, and modeli

174 Linkage analysis of >13,500 single-nucleotide polymorphi

175 y new CAD genetic loci through a large-scale linkage analysis of 24 large and multigenerational famil

176 oma in some but not all cases in the family, linkage analysis of 31 families subsequently identified

177 also successfully replicated in our previous linkage analysis of 428 nuclear families.

178 any compelling associations, but parametric linkage analysis of 460 families (1062 affected individu

179 Linkage analysis of 486 sibling pairs from the family ba

180 We further carried out combined linkage analysis of 53 multiplex families with AP and 36

181 Through linkage analysis of a cross-intercross of these two pare

182 Linkage analysis of AD identified the strongest linkage

183 Linkage analysis of affected families, including a very

184 A genome-wide linkage analysis of backcrossed animals with EAG reveale

185 Through linkage analysis of crosses between the C57BL/6J (B6), B

186 Study and performed a model-free genome-wide linkage analysis of fibromyalgia with 341 microsatellite

187 We conducted a genome-wide linkage analysis of IGRA phenotypes in families from a t

188 n Leishmania, opening the way toward genetic linkage analysis of important traits and providing stron

189 Linkage analysis of liver metabolomic profiling data ide

190 mmunosorbence-based screens and carbohydrate linkage analysis of polysaccharides in Golgi membranes,

191 ral phenotyping of the families also enabled linkage analysis of quantitative measures, including nor

192 However, linkage analysis of seed carotenoids in Arabidopsis thal

193 e controlled by a large number of genes, and linkage analysis of several traits implicates a 'common

194 antitative refraction and refractive errors, linkage analysis of spherical equivalent, myopia, and hy

195 is, to our knowledge, the first genome-wide linkage analysis of the extended Utah high-risk CMM pedi

196 Combined linkage analysis of the two families confirmed that RTTN

197 Through the parallel linkage analysis of the two NAM panels, both common and

198 Comparative linkage analysis of these differences is currently under

199 crostructure was determined using oligogenic linkage analysis of this large multigenerational pedigre

200 assical univariate and bivariate genome-wide linkage analysis of TNF production using the data from b

201 We identified the disease locus through linkage analysis on 15q21.2, and exome sequencing reveal

202 Here, by exome sequencing and linkage analysis on a Chinese family with autosomal domi

203 ld dataset, performing parametric multipoint linkage analysis on a highly consanguineous pedigree wit

204 K cell functional maturation, we performed a linkage analysis on F2 (B6.Rag1(-/-) x NOD.Rag1(-/-) int

205 a variant-level and a gene-level parametric linkage analysis on nine PNTM families (16 affected and

206 ple members affected with focal epilepsy and linkage analysis on one of these.

207 three different inbred strains and performed linkage analysis on the DPOAE data obtained from the sec

208 ring cleavage ions are potentially useful in linkage analysis, one of the most critical steps of glyc

209 me a widely used epidemiological method like linkage analysis or genome-wide association analysis.

210 ool capable of modeling genetic association, linkage analysis, polygenic effects, shared environment,

211 Linkage analysis produces two separate complementary mar

212 version and a 109x speed-up over the popular linkage analysis program SIMWALK.

213 Linkage analysis ranked the TTN region as falling under

214 ng has allowed researchers to move away from linkage analysis (relying on large pedigrees and/or mult

215 Linkage analysis remains an important tool in elucidatin

216 The observed heterogeneity in linkage analysis results may just be a reflection of the

217 Here, in the four-generation family UW-AP, linkage analysis revealed four regions that provided the

218 Initial genome-wide linkage analysis revealed suggestive linkage to chromoso

219 Genome-wide linkage analysis revealed that EEM was linked to the 6q2

220 Linkage analysis revealed that fucopyranoside units alon

221 Genome-wide linkage analysis revealed two small candidate regions on

222 Linkage analysis, reverse genetic approaches, and molecu

223 Model) and SOLAR-MGA (Sequential Oligogenic Linkage Analysis Routines -Major Gene Analysis) have sim

224 ODS AND We used SOLAR (Sequential Oligogenic Linkage Analysis Routines) to evaluate heritability of A

225 alculated using SOLAR (Sequential Oligogenic Linkage Analysis Routines).

226 Using Sequential Oligogenic Linkage Analysis Routines, the genetic correlations betw

227 as implemented in the Sequential Oligogenic Linkage Analysis Routines, was used to estimate heritabi

228 digree information and Sequential Oligogenic Linkage Analysis Routines.

229 Unfortunately, methods to perform multipoint linkage analysis scale poorly with either the number of

230 Linkage analysis showed a 7-Mb candidate interval on chr

231 Two-point linkage analysis showed positive linkage between cold so

232 Before linkage analysis, single-nucleotide polymorphisms were p

233 Early linkage analysis studies in Mendelian forms of these dis

234 s of the TbGnTII null mutants by methylation linkage analysis suggests that, in wild-type parasites,

235 of diabetes complications relied on familial linkage analysis suited to strong-effect loci, candidate

236 omplementary approaches, including classical linkage analysis, targeted next-generation sequencing, a

237 Genetic studies included linkage analysis, targeted Sanger sequencing, and next-g

238 The steps of the linkage analysis (testing for distorted segregation, clu

239 Here, we describe an alternative approach to linkage analysis that makes use of a nonreversible deute

240 Using a genome-wide linkage analysis, the ASD disease locus was mapped to ch

241 In this study, we perform an unbiased linkage analysis to determine the genetic loci that may

242 and assess a statistical design that deploys linkage analysis to estimate and test the pattern and ex

243 As a proof of concept, we have used linkage analysis to identify 36 high-confidence novel ed

244 xome sequencing, array-based genotyping, and linkage analysis to identify putative pathogenic variant

245 Here, we use linkage analysis to map the chromosomal location of the

246 ode of discovery has been the application of linkage analysis to mouse crosses.

247 ker panel, a subset of which may be used for linkage analysis to reduce computational burden and to l

248 Here, we have used linkage analysis to show that both mRNA editing and alte

249 We used whole-genome sequencing with linkage analysis to study a consanguineous family with e

250 We have employed cysteine labelling and linkage analysis to the full length of Bak in mitochondr

251 Quantitative trait linkage analysis using 261 microsatellite markers identi

252 The genome-wide variant-level linkage analysis using 4,328 independent common variants

253 To identify candidate loci, we performed linkage analysis using 5 p.G206A carrier families (n = 5

254 In nonparametric linkage analysis using an exponential model, we found th

255 We did genome-wide linkage analysis using data from multi-incident Arab-Ber

256 Linkage analysis using inbred mouse strains identified a

257 Linkage analysis using this growth inhibition phenotype

258 omosome 6 were then tested in the gene-level linkage analysis, using the collapsed haplotype pattern

259 Genome-wide linkage analysis was carried out in 14 family members fo

260 Joint family linkage analysis was conducted with 7,386 markers in the

261 Linkage analysis was largely supplanted by the wide adop

262 Linkage analysis was performed and the disease locus nar

263 Linkage analysis was performed by testing for associatio

264 Genetic linkage analysis was performed in a family with a PCD su

265 A genome-wide STR and SNP based linkage analysis was performed in one large family that

266 Parametric genomewide linkage analysis was performed on 10 affected family mem

267 Single-nucleotide polymorphism-based linkage analysis was performed on DNA samples from the 4

268 Genome-wide linkage analysis was performed to map the locus.

269 Data linkage analysis was performed with the Office for Natio

270 selecting markers in the genome scanning of linkage analysis was replaced by estimating polygenic va

271 For many years, linkage analysis was the primary tool used for the genet

272 iants shared in all affected individuals and linkage analysis was used to further filter shared varia

273 us on chromosome 3, originally identified by linkage analysis, was in fact due to three closely linke

274 Through a genome-wide linkage analysis, we detected a locus for autosomal-domi

275 Using linkage analysis, we have mapped the position of this mu

276 Using family linkage analysis, we identified a keratoconus susceptibi

277 by analyzing families with recurrent SPTB in linkage analysis, we identified a linkage peak close to

278 Using quantitative trait linkage analysis, we identified Id2, a homolog of Id3, t

279 Using a combination of exome sequencing and linkage analysis, we investigated an English family with

280 By linkage analysis, we mapped a locus at 1p36.22 containin

281 By linkage analysis, we mapped the Tsk2 gene mutation to <3

282 In combination with linkage analysis, we performed whole-genome sequencing o

283 tural amino acid substitution and a standard linkage analysis, we show that a His97' NH(epsilon2)...O

284 sis and single-nucleotide polymorphism-based linkage analysis were investigated in a 4-generation fam

285 atients followed by homozygosity mapping and linkage analysis were performed.

286 We performed linkage analysis, whole-exome and whole-genome sequencin

287 sease-associated mutations were sought using linkage analysis, whole-exome sequencing, and copy numbe

288 Exclusion of known ADTKD genes coupled with linkage analysis, whole-exome sequencing, and targeted r

289 Multipoint parametric linkage analysis with 13 members of this family identifi

290 We combined a genome-wide linkage analysis with cell biology, microscopy, and mole

291 We combined genome-wide linkage analysis with exome sequencing and identified 14

292 h PauR were also suggested by chemical cross-linkage analysis with glutaraldehyde.

293 ither through follow-up interviews or record linkage analysis with hospital discharge and PD outpatie

294 rhosis in the cohort was ascertained through linkage analysis with nationwide death registry.

295 n of the pedigree was performed, followed by linkage analysis with the redefined disease statuses, an

296 In this study, we combined linkage analysis with whole-exome sequencing of two indi

297 Here we combine linkage analysis with whole-genome resequencing in patie

298 ed all 49 heritable phenotypes using genetic linkage analysis, with special emphasis on phenotypes ju

299 disease gene to be on chromosome 19p13, and linkage analysis yielded a combined multipoint log(10) o

300 Genome-wide linkage analysis yielded a maximum two-point logarithm o