ライフサイエンスコーパス: linker region

1 domains (N- and C-terminal lobe) joined by a linker region.

2 ent of SRP domains connected by the flexible linker region.

3 te HCN and CNG channels and that contain a C-linker region.

4 in the amino-terminal domain and downstream linker region.

5 mTORC1 and/or ERK, including new ones in the linker region.

6 nabled by negatively charged residues in the linker region.

7 cted to a C-terminal hook-like segment via a linker region.

8 ansducer, via phosphorylation of the Smad1/5 linker region.

9 p on the substitution pattern of the C22-C24 linker region.

10 dimerization domain, connected by a flexible linker region.

11 cularly inhibited by the adjacent C-terminal linker region.

12 l domain of approximately 16 kDa by a narrow linker region.

13 eside in two separate domains connected by a linker region.

14 omatic moieties as well as the amino alcohol linker region.

15 omologous to prokaryotic IF3, connected by a linker region.

16 consists of two globular domains joined by a linker region.

17 ir C terminus as well as in the proline-rich linker region.

18 the C terminus as well as at an interdomain linker region.

19 ia MAPK-mediated phosphorylation of the Smad linker region.

20 se 1/2-dependent phosphorylation of the SMAD linker region.

21 sidual activity depends significantly on the linker region.

22 o-localizing with rootletin and Cep68 in the linker region.

23 hich is connected to the channel pore by a C-linker region.

24 ne Hsp33 requires the unfolding of a central linker region.

25 embly domain, and portions of an intervening linker region.

26 n to polysialylate O-glycans on the adjacent linker region.

27 s by systematic chemical modification of the linker region.

28 new elements of dynamic structure within IDP linker regions.

29 n the loss of glycosylation of three of four linker regions.

30 ving phosphorylation sites in their tail and linker regions.

31 me midpoints rather than in internucleosomal linker regions.

32 ilitates GGR, especially in internucleosomal linker regions.

33 xtended conformations of the two interdomain linker regions.

34 onal plasticity, most notably in surrounding linker regions.

35 aracterized motifs joined by less understood linker regions.

36 not inhibit catalysis as a result of missing linker regions.

37 atalytic core domain-carboxy-terminal domain linker regions.

38 What are the rules and roles of the linker regions?

39 whereas iASPP predominantly interacts with a linker region adjacent to the core domain.

40 Mutations to the linker region affect neither catalytic rate nor domain-d

41 Within this linker region all herpesviruses contained a conserved, h

42 epeats arranged in series are unique in that linker regions also feature calcium-binding motifs.

43 we investigated the importance of a flexible linker region (amino acids 93-111, referred to hereafter

44 s several regulatory elements, including a C-linker region and a cyclic nucleotide-binding domain (CN

45 e known (main) binding site, we identified a linker region and a secondary binding site that are cruc

46 distinct SMAD3 phosphorylation sites at the linker region and at the C terminus determined the up-re

47 similarities between Hsp33's own metastable linker region and client proteins present a possible mod

48 from interactions between the H1-like basic linker region and DNA around the entry/exit site, which

49 naling response by phosphorylating the Smad2 linker region and enhancing the level of Smad2 activatio

50 onformational variability of residues in the linker region and of dimer and trimer interfaces.

51 ty centered on the Envelope (E) domain I/III linker region and protects mice from viremia and viral d

52 f the Hsp70 cycle via conserved parts of the linker region and reveal the mechanism of DNAJB6b oligom

53 Many of these mutations are in the linker region and the RING finger of CBL, leading to a l

54 have extended the SAR studies to include the linker region and the surface recognition group to optim

55 e first defined the WT structure of the cTnT-linker region and then identified Delta160E mutation-ind

56 (FNIII9(4G)10) insertion in the interdomain linker region and used surface plasmon resonance to dete

57 epitope is less constrained by the flanking linker regions and is positioned so that the symmetry of

58 ins in pyrin include a pyrin domain (PYD), a linker region, and a B30.2 domain.

59 ture of DsbP reveals an N-terminal domain, a linker region, and a C-terminal catalytic domain.

60 en consecutive N-terminal ankyrin repeats, a linker region, and a C-terminal phospholipase catalytic

61 ase domain, a regulatory segment, a variable linker region, and a hub domain, which is responsible fo

62 embrane SNARE complex proteins via a central linker region, and contains tandem C-terminal C2 domains

63 microtubule-binding domain and unstructured linker region, and indirectly, through an allosteric eff

64 rs of its tandem BRCT domain, the BRCT-[N-C] linker region, and the alpha1 and alpha'1 helices in BRC

65 to the end of the helix C of repeat 14, the linker region, and the B-C loop of repeat 15.

66 ther mutations in the N-terminal domain, the linker region, and the C-terminal domain had little or n

67 g that conformational changes involving this linker region are critical to the GABA activation pathwa

68 ors with a novel alkoxyamide connecting unit linker region are described.

69 rence and a novel alkoxyurea connecting unit linker region are described.

70 erine/threonine phosphorylation sites in the linker region are followed by the proline residue.

71 nce and possibly structural features of this linker region are indispensable for the kinase activity

72 , it is concluded that stable intact helical linker regions are needed to maintain the soft elasticit

73 in the hexamer central pore, and the NTD-CTD linker region, are well defined.

74 The linker region (Arg-394-Pro-411) between the N terminus o

75 uble N terminus of TatC and the interhelical linker region around the conserved glutamyl residue Glu(

76 identified amino acids 290-300 of the Smad4 linker region as critical for the specific interaction o

77 rved residues (R151, I155) in the syntaxin-1 linker region as key sites for the MUN domain interactio

78 d spin labeling in which we characterize the linker region as well as the cis (vesicle membrane) and

79 , increased occupancy of the nucleosome-free linker region at the insulator site, and increased repre

80 g of ECD and TMD and the conformation of the linker region at the interface of ECD and TMD are of par

81 interacting and trafficking domains relieves linker region autoinhibition of the VSE to produce maxim

82 sites to an O-glycan cluster located in the linker region between b2 and c domain.

83 s of highly conserved serine residues in the linker region between domains I and II of genotype 2a JF

84 YopO phosphorylated gelsolin in the linker region between gelsolin homology domains G3 and G

85 rough cis-trans proline isomerization in the linker region between MLL1's third PHD finger and bromod

86 ts in potency were realized by extending the linker region between the 6-(S) position and the termina

87 a major conformational change occurs in the linker region between the D1 and D2 domains, which is di

88 OLGs increases the flexibility of the hinge linker region between the D3 and A1 domain, facilitating

89 The linker region between the domains is a dynamic random co

90 us assembly is sensitive to mutations in the linker region between the helicase and protease domains

91 diated partly by a highly negatively charged linker region between the KHC-interacting and cargo-bind

92 cies with a 10-fold length difference in the linker region between the kinase domain and holoenzyme h

93 found developmental delay, is located in the linker region between the ligand-binding and transmembra

94 This activity localizes to the charged linker region between the longin and GTPase domains of S

95 We found that the 40-amino acid linker region between the MIT and the ATPase domain of V

96 est that amino acids 487-501, located in the linker region between the N-terminal domains and the cat

97 onal assays identified Cys124 located in the linker region between the N-terminal pleckstrin homology

98 role in dimerization in solution, while the linker region between the predicted N-terminal coiled-co

99 ation and amino acid deletion shows that the linker region between the PX and N-terminal SH3 domain p

100 The deafness mutation D101G, in the linker region between the repeats, causes a slight bend

101 Here, we have examined the role of the linker region between the TRPM8 inner gate and the TRP b

102 on of a tyrosine residue (Y380) found in the linker region between the two catalytic domains of the e

103 hows a unique, well-ordered structure of the linker region between the two dsRBDs that differs from t

104 ithin the CX5C or CX3H regions or within the linker region between the two fingers also perturbed bot

105 al ubiquitin-like (Ubl) domain and the short linker region between the two Ubl domains, explaining wh

106 l domain, the N-terminal zinc finger and the linker region between the two zinc fingers.

107 A flexible linker region between three fragments allows antibodies

108 We find that the short linker regions between LDLR class A repeats contain an e

109 Our studies demonstrate that linker regions between modular domains can contribute to

110 equence indicates certain enriched motifs in linker regions between nucleosomes and reveals a sequenc

111 The linker regions between repeats are thus critical determi

112 y we identified O-glycosylation sites in the linker regions between the characteristic LDLR class A r

113 inding domain, transmembrane domain, and the linker regions between these domains were particularly i

114 cross-link with the PBS are situated in the linker region, between the N- and C-terminal domains and

115 g domains, and a protein containing just the linker region bind to thin filaments with about a 1:1 mo

116 The crystal structure of the Pan2 linker region bound to a Pan3 homodimer shows how the un

117 Chaetomium thermophilum (ctPRC2), a flexible linker region, but not the H3K27M cancer mutant peptide,

118 s, they are phosphorylated at an interdomain linker region by CDK8 and CDK9, which are components of

119 eport that the phosphorylation of Mad in the linker region by the Wg antagonist Zw3 (homolog of verte

120 When PCBP2 is cleaved in its linker region by viral proteinase 3CD, translation initi

121 of Nrf2 was accompanied by concomitant Smad linker region/C-terminus phosphorylation, induction of t

122 The mechanistic complexity of the linker region can be described by a spring model with Br

123 whereas occasional kinks in the proline-rich linker region cause an overall bend in the PRD structure

124 ly bound to Munc18-1, whereas the syntaxin-1 linker region changes its conformation, similar to that

125 Ks play a role in IL-1beta activation of the linker region, chondrocytes were preincubated with speci

126 We address questions such as: Where did the linker regions come from?

127 amino acid lysine to arginine within the p47 linker region completely abrogated molecular interaction

128 The resulting models imply that the linker regions confer great flexibility between domains,

129 ed His-rich cluster (His-Gly-His-His) in the linker region connecting its two catalytic domains sense

130 ne/proline consensus motifs localized in the linker region connecting PDZ2 to PDZ3 domains.

131 show that insertion of nine amino acids in a linker region connecting the different TTD and PHD histo

132 ved, indicating hinge bending motions at the linker region connecting the head to the transmembrane h

133 monstrated that the C-terminal helix and the linker region connecting the N-terminal coiled-coil doma

134 We discovered a role for the unstructured linker region connecting the N-terminal oligomerization

135 The 20-residue linker region connecting the two conserved domains of Co

136 e domain (CYT(CDH)) containing heme b, and a linker region connecting the two domains.

137 We found that the intrinsically disordered linker region connecting the two RNA recognition motif (

138 ing a 12-amino-acid deletion in the CYP102A1 linker region, connecting the catalytic heme and the dif

139 man AMPK was abolished when a portion of the linker region containing the alpha-hook domain was delet

140 s, nucleosome phasing shifts to increase the linker region containing the EPO-R transcription start s

141 revealed that conformational changes in the linker region contribute to mobility of the catalytic do

142 -194 contain the Hc alpha-helix and flexible linker region controlling transition of syntaxins betwee

143 s within the first EF-hand domain and the XY linker region dramatically reduces the binding of PLCzet

144 unidentified role for the E protein DI/DIII linker region during the DV2 assembly process.

145 previously unidentified role for the DI-DIII linker region during the low-pH-dependent refolding of E

146 e BRICHOS domain, possibly together with the linker region, during pro-SP-C biosynthesis in the ER.

147 o different protein domains and inter-domain linker regions encoded in the non-LTR retrotransposons,

148 reveal that the partial unfolding of Hsp33's linker region facilitates client binding to an amphipath

149 While the linker regions for the EC1'-EC2' and EC3'-EC4' pairs dis

150 extended Mint1 PTB fragment reveals that the linker region forms a short alpha-helix that folds back

151 omain, and achieved via removal of the LNRAB linker region from the HD domain.

152 When overexpressed in MIN6 cells, this Hc-linker region functioned as a competitive inhibitor of e

153 e key UPR sensor IRE1 within its cytoplasmic linker region, generating a stable IRE1 fragment compris

154 The N-linker region has high mechanical lability and acts as t

155 r Src homology (SH) 3 domains and SH2 kinase linker regions has a key role in down-regulation of kina

156 of structures of ABC transporters containing linker regions has allowed us to identify the start and

157 phosphorylation at three sites in the Smad3 linker region in addition to the two C-terminal residues

158 sults highlight an active role of the PX-SH3 linker region in maintaining p47 (phox) in its fully aut

159 LSD2 alone and LSD2 in complex with the NPAC linker region in the absence or presence of histone H3 p

160 nexpected set of favorable contacts from the linker region in the aminoacylation sensing module.

161 ed as a single polypeptide with a 31-residue linker region in the middle of the protein.

162 d REMSA demonstrate the accessibility of the linker region in the PCBP2/SLIVm complex and consequent

163 The linker region in the resulting product contains an exocy

164 luencing catalytic activities, the WW domain linker regions in NEDD4-1 and WWP2 can impact product di

165 the conformational change of the syntaxin-1 linker region induced by Munc13-1 initiates ternary SNAR

166 by the regulatory domain and how the kinase linker region interacts with the regulatory nucleotide-b

167 ve been studied extensively, the role of the linker region is less well known, despite the potency of

168 ircular dichroism studies, suggests that the linker region is not extended but folds into a domain st

169 This linker region is part of the subunit interface between m

170 The h1-h2 linker region is predicted to form an unexpected beta-ha

171 particularly if the intervening polyproline linker region is retained.

172 ted threonine 179-proline motif in the Smad3 linker region is the major binding site for Pin1.

173 This linker region is the site of adaptive mutations.

174 in a manner dependent upon the unstructured linker region joining the amino-terminal microtubule int

175 Here, we identify a "linker region" (KSRKERERLEEK) that connects the TM senso

176 Mutations in the pro-SP-C BRICHOS domain or linker region lead to amyloid formation of the SP-C prot

177 cal connection between the transmembrane and linker regions, leading to an apparently new characteriz

178 not Wnt/GSK3, phosphorylation of the Smad1/5 linker region localizes to a ventral vegetal gastrula re

179 Vif contains a flexible linker region located at the hinge of the VCBC complex,

180 ) and an effector domain (ED) separated by a linker region (LR), is implicated in replication, pathog

181 effector domain (ED) separated by a flexible linker region (LR).

182 h domains fold in an independent manner, the linker region makes polar interactions with the catalyti

183 highly dynamic protein in which part of the linker region masks the Hsp70 binding site.

184 de-modulated channels, suggesting that the C-linker region may be highly dynamic in the KCNH, hyperpo

185 ectrostatic repulsion in the heptad repeat B linker region may contribute to the triggering of HMPV F

186 Analysis of a DLC1 linker region mutant and a START domain mutant showed ea

187 Compared with the wild-type, the linker region mutant bound 14-3-3 proteins less efficien

188 ed crystal structures of the wild type and a linker region mutant of the H6N6 NS1 (A/blue-winged teal

189 One such linker region mutant, A257T, is analogous to the A359T m

190 stigated the mechanism by which CBL-Y371H, a linker region mutant, and CBL-C384R, a RING finger mutan

191 rises from its central domain, with a short "linker" region narrowed to within amino acids 324-348, b

192 cision when the lesion is present in the DNA linker region of a nucleosome.

193 Mechanistically, this linker region of caspase 8 acts as a Src homology 2 bind

194 tion of a critical tyrosine (Tyr-341) in the linker region of Cbl-c by Src or a phosphomimetic mutati

195 tained from the binding between LSD1 and the linker region of CoREST are similar to those obtained fr

196 presence of the matrix-exposed, unstructured linker region of Cox15 needed for Cox15 oligomerization,

197 GFP viruses with mutations in the head-stalk linker region of HN.

198 D2 and D1 domains) is mediated by the D1-D2 linker region of its neighboring protomer.

199 of cysteine thiol groups by inducers in the linker region of Kelch-like ECH-associated protein-1 (Ke

200 e additional scissile bonds in an N-terminal linker region of LTBP4 that connects fibulin-5/tropoelas

201 In the linker region of Mcd1p, we identified a novel evolutiona

202 ase (MAM) domain and the O-glycan-containing linker region of neuropilin-2 are necessary and sufficie

203 ated across tumor types, as exemplified by a linker region of PIK3CA in which biophysical simulations

204 was due to changes in basic residues in the linker region of PLN.

205 eracts with RSK2 through residue W332 in the linker region of RSK2 and that this association is requi

206 The linker region of seven residues in NS5, rich in serotype

207 the glycogen-binding domain of Gal83 or the linker region of the alpha subunit were competent for AD

208 eptible to proteolysis within the N-terminal linker region of the first calcium-binding epidermal gro

209 main (which lacks the SH3 domain including a linker region of the full length protein), we observe a

210 ENP-B box sequence was located in the distal linker region of the nucleosome.

211 cts with a separate less-conserved polybasic linker region of the protein.

212 m SH2 domain of S. cerevisiae Spt6 binds the linker region of the RNA polymerase II subunit Rpb1 rath

213 Truncation of a charged linker region of yeast Hsp90 (Hsp82Deltalinker) was know

214 KBP prolyl isomerase enzymes is recruited to linker regions of chromatin.

215 In addition, due to the fact that naked linker regions of DNA in the interphase and metaphase of

216 The glycosites in linker regions of LDLR class A repeats are conserved in

217 oform(s) contributed to glycosylation of the linker regions of the LDLR class A repeats by in vitro e

218 ultimately fusion, are the transmembrane and linker regions of the vesicle-associated protein, synapt

219 tabilizes the relative positions of the neck linker regions of ZEN-4.

220 nding to GAF-B causes movement, through this linker region, of the catalytic domains, such that the H

221 To quantify the role of disorder in the RAM linker region on the effective concentration enhancement

222 Second, the DT linker region participates in distance determination, as

223 inding (EF hands I, II, III, and IV) and the linker region (peptide 78-86) undergo conformational cha

224 naling in the absence of DLC1 mediated SMAD3 linker region phosphorylation and TGF-beta-induced expre

225 s, Tak1 regulates both R-Smad C-terminal and linker region phosphorylation in TGF-beta signaling.

226 lly, we demonstrate that the agonist-induced linker region phosphorylation of Smad2 at Thr-220, which

227 ays a role in agonist-induced C-terminal and linker region phosphorylation of the receptor-mediated R

228 ent ERK MAP kinase activity leading to Smad3 linker region phosphorylation.

229 idence, also generated by SDSL-EPR, that the linker regions play a key role in IF structure and regul

230 the redox-controlled unfolding of the Hsp33 linker region plays the central role in the activation p

231 eas CrkII possesses in addition a C-terminal linker region plus a SH3 domain, which operate as regula

232 (SNAG) and zinc finger motifs separated by a linker region poorly conserved with GFI1B, its closest h

233 our studies reveal the critical role of the linker region (positioned between the CNB domain and the

234 eosome occupancies, because cleavages within linker regions produce oligo- and mono-nucleosomes, wher

235 Short intersubunit linker regions provide the molecular basis for flexibili

236 A linker region (residues 62 to 66) between two gH/gL bind

237 domains) and Gaussian Bayes classifiers (for linker regions), respectively.

238 studies suggest that these mutations in the linker region result in a rearrangement within the cr-u-

239 -beta-induced phosphoThr-ProTyr motif in the linker region, resulting in Smad2/3 polyubiquitination a

240 ncluding residues comprising the interdomain linker region, revealed an expanded heterodimer interfac

241 the function of four conserved motifs in the linker region, revealing a key role for a conserved PXXP

242 -terminal domain and are joined by a charged linker region rich in serine and arginine residues (SR l

243 C-terminal domain (CTD), joined by a charged linker region rich in serine and arginine residues (SR-r

244 ous norovirus cleavage sites inserted into a linker region separating cyan fluorescent protein and ye

245 ta signaling caused phosphorylation of Smad3 linker region (Smad3L) at Ser213, resulting in the up-re

246 erminal residue E220 and the residues of the linker region stabilized a compact structure of TIS11d i

247 The presence of conserved Gly residue in the linker region suggests that flexibility between the tran

248 the BRICHOS domain or in its peptide-binding linker region supports the in vivo relevance of the prop

249 rentiation and generates a longer nucleosome linker region surrounding the GATA1 sites by shifting th

250 catalysis: (1) an N-terminal tail and (2) a linker region tethering DHFR to TS, and encoding a cross

251 average, 10-15% lower substitution rates in linker regions than in nucleosomal DNA.

252 oligomerization is driven by an interdomain linker region that acts as a latch to 'catch' the neighb

253 ally, a Syntaxin1A mutant lacking a flexible linker region that allows NRD movement abolished stimula

254 thus identify 10 residues in the interdomain linker region that change their conformations upon subst

255 We also know little about the linker region that connects the inhibitor site to the N-

256 ey clustered within and flanking the central linker region that connects the two catalytic domains an

257 n1 and hRpn13, as expected from the flexible linker region that connects the two UIMs; nonetheless, h

258 subunit of the alpha(1)beta(2) GABA(A)R in a linker region that is believed to span the subunit.

259 as a series of insertion mutants in the A-M3 linker region that led to significant shifts in measured

260 olerance of hydrophilic substitutions in the linker region that was exploited to improve the fraction

261 ged in series, with either flexible or rigid linker regions that determine their elasticity.

262 s 93-111, referred to hereafter as the "mini-linker" region) that separates the zDABM and S-acylated

263 hreonine 179 and other residues in the Smad3 linker region the same as TGF-beta, Pin1 is unable to bi

264 L4 and in the 130s region, the intersubunit linker region, the 26-32 region as well as in the stabil

265 s to the constitutive unfolding of the Hsp33 linker region thereby turning Hsp33 into a constitutivel

266 its dsRNA-binding motif 2 to bind dsRNA, its linker region to interact with Dicer, and its C-terminus

267 Similarly, the addition of the linker region to the AAV5 Rep endonuclease domain also c

268 ggle that adjusts the thermostability of the linker region to the cell redox status.

269 action between the ligand-binding domain and linker region to the pore that regulated channel desensi

270 NSD3 to mononucleosomes causes DNA near the linker region to unwrap, which facilitates insertion of

271 ed the contribution of each of the HAMP-like linker regions to the functionality of DhNik1p and found

272 regulated via a conformational change in the linker region, triggering a movement of the N-terminal d

273 otif disengaged from its Habc domain and its linker region unfolded.

274 rin on Ser(169) located in the SH2-C1 domain linker region via protein kinase Cdelta, which retained

275 alternative phosphorylation of R-Smad in the linker region via the MAPK pathway (primarily p38 and JN

276 Flexibility of the linker region was found to be important for the reorient

277 ed that the calmodulin domain binding to the linker region was important for regulating the distance

278 A SNAP25 mutant in which the mini-linker region was substituted with a flexible glycine-se

279 (bp) that accumulate in long internucleosome linker regions was more efficient for identifying transc

280 ethods that map nucleosomes based on cuts in linker regions, we utilize DNase I cuts both outside and

281 smembrane segments S3-S5+S6 and the DIII/DIV linker region were associated with high probability of p

282 tion, and residues 340-356 of the SH2 kinase linker region were identified to be important for suppre

283 ch the lipophilic tail, polar headgroup, and linker region were modified to extend the structure-acti

284 Single residues in the S3-S4 linker region were substituted with cysteine, and the cy

285 r oxidation occurs for residues of the first linker region, whereas greater oxidative modifications o

286 fferent effects in different contexts; and a linker region which connects the second helix of Rev to

287 eotide-gated (CNG) channels, MloK1 lacks a C-linker region, which critically contributes to the molec

288 regulated by phosphorylation of Y221 in the linker region, which forms an intramolecular SH2-pY221 a

289 nsic conformational energy difference of the linker region, which is identical for both dimers.

290 This flexible linker region, which is unique for each K(2P)-channel su

291 sence of oxidants and an adjacent metastable linker region, which responds to unfolding conditions.

292 causes moderate destabilization of the Hsp33 linker region, which seems sufficient to convert the red

293 Mutations in the TFIIB reader and linker region, which were inactive on duplex DNA, were s

294 ylation of SMAD2 and SMAD3 proteins at their linker regions, which negatively regulated the TGF-beta

295 residues 293-380, also known as the CoREST "linker" region, which is a central isolated helix that i

296 proximately 4.4 nm by 5.8 nm) separated by a linker region with a diameter of approximately 3 nm, fol

297 at connect the domain I-domain III (DI-DIII) linker region with the E1 core trimer, including H3.

298 two inhibitors differ only in their central linker regions, with compounds 1 and 2 containing a sing

299 inantly via the destabilization of the Hsp33 linker region without affecting zinc coordination, redox

300 y that recognizes the conserved zinc fingers linker region (ZnFL) in multiple KRAB-ZNF.