ライフサイエンスコーパス: lipidate

1 from lipA, lipB, and lipA lipB mutants were lipidated.

2 protein was found to be surface exposed and lipidated.

3 ane-associated form of apoB-100 is partially lipidated.

4 n activity, the substrate is intracellularly lipidated.

5 Combining one recombinant lipidated 2086 (rLP2086) variant from each subfamily wit

6 the lysine resonances in the spectrum of the lipidated 22-kDa fragment were made.

7 results were observed in mice immunized with lipidated (56%-98%; mean, 69%; SD, 13.6%) and combinatio

8 munization, we have developed an approach of lipidating a multiple Ag peptide (MAP) containing part o

9 etermined hydrodynamic properties of the non-lipidated AcrA and found that AcrA exists in solution as

10 However, lipidated Ag delivered in microparticles induced higher

11 , expression of a palmitoylation-independent lipidated AKAP mutant in DHHC2-deficient neurons largely

12 Treatment of mice with lipidated albumin to induce proteinuria caused a decreas

13 cture-activity studies revealed that certain lipidated alpha-peptide/beta-peptoid hybrid oligomers po

14 pecific interaction of a fluorophore-labeled lipidated alpha-peptide/beta-peptoid hybrid with monocyt

15 We identified a novel, lipidated amino acid, N-pal-gln, that is positively asso

16 combinant forms of the antigen having either lipidated amino termini, approximating the natural secre

17 Insulin icodec, a novel ultralong-acting lipidated analog validates the concept of a once-weekly

18 luble membrane anchored ligand, we generated lipidated analogs of the 9-amino acid fragment.

19 Wnt3 proteins are lipidated and glycosylated signaling molecules that play

20 Purified non-lipidated and intact forms of AcrA were able to restore,

21 Finally, we demonstrate that lipidated and non-lipidated apoA-I significantly decreas

22 th Bacteria and Archaea, potentially in both lipidated and nonlipidated forms.

23 and dynamic light scattering measurements of lipidated and nonlipidated YcjN proteins suggest that li

24 amino-terminal domain (HhN), which is dually lipidated and secreted as part of a multivalent lipoprot

25 Moreover, the expression of lipidated antigens in E. coli BL21(DE3)DeltaompADeltamsb

26 riven (enzymatic) pathways in lipid-poor and lipidated apoA-I (reconstituted HDL).

27 tion, all simulated double belts of the four lipidated apoA-I particles have helical domains that imp

28 nally, we demonstrate that lipidated and non-lipidated apoA-I significantly decreased Abeta toxicity

29 us formation of more than one type of poorly lipidated apoA-I-containing particle: there were 9- and

30 idation as they secrete both unlipidated and lipidated apoB forms despite their lack of microsomal tr

31 Importantly, enhancing ABCA1 activity to lipidate ApoE reduced ApoE and ABCA1 aggregation.

32 ABCA1 membrane recycling and its ability to lipidate ApoE.

33 h amyloid plaques, demonstrating that poorly lipidated apoE co-deposits with insoluble Abeta.

34 timal receptor-binding activity by the fully lipidated apoE during lipoprotein transport in circulati

35 urity in preventing lipid-free and partially-lipidated apoE from premature binding to apoE receptors

36 Cryogenic electron microscopy of recombinant lipidated ApoE further supports ApoE adopting antiparall

37 CX, whereas levels of lipoprotein-associated/lipidated apoE have the opposite pattern (6 months).

38 onate-insoluble apoE, suggesting that poorly lipidated apoE is less soluble in vivo.

39 Structural models of lipidated ApoE of high resolution could aid in a mechani

40 fragments, we characterize the structure of lipidated ApoE on astrocyte-secreted lipoproteins.

41 pite substantially lower apoE levels, poorly lipidated apoE produced in the absence of ABCA1 is stron

42 Together, these data show that lipidated apoE, especially apoE4, increases Abeta oligom

43 The enhanced expression of lipidated ApoE, through the activation of liver X recept

44 ding cassette family of active transporters, lipidates apoE in the CNS.

45 lipoprotein (LDL) receptor (LDLR) binding of lipidated ApoE2 (lipApoE2) avoids LDLR recycling defects

46 With lipidated apoE3, it is confirmed that the Lys-233 site i

47 ide, which increased the proportion of large lipidated ApoE4 particles, corrected these abnormalities

48 Selectively removing non-lipidated apoE4-Abeta co-aggregates enhances clearance o

49 poor ApoE4 protein is prone to aggregate and lipidating ApoE4 protects it from aggregation.

50 s display a marked elevation in secretion of lipidated apolipoprotein B-100.

51 In mouse primary neuronal culture, lipidated apolipoprotein E4 enhances oligomeric amyloid-

52 Both peptides were lipidated at the N-terminus by transfer from PC, phospha

53 es, we demonstrate that Atg1 is activated by lipidated Atg8 (Atg8-PE), stimulating substrate phosphor

54 biquitylated proteasome subunits/targets and lipidated ATG8 lining the enveloping autophagic membrane

55 autophagosomal membrane by interacting with lipidated ATG8 proteins (LC3/GABARAP) that are intimatel

56 sed by host autophagy proteins engaging only lipidated Atg8 proteins.

57 to the phagophore through interactions with lipidated ATG8/LC3 decorating the expanding membrane.

58 Lipidated ATG8s anchored to the outer surface of the pha

59 aphylococcus produced strong accumulation of lipidated autophagy-related protein LC3B (LC3B-II).

60 We report here on the co-assembly of lipidated beta-sheet-forming peptides with soluble short

61 oscopy through EV surface immobilization via lipidated biotin-DNA handles.

62 GABARAP, unlipidated and lipidated, but not LC3B, GABARAPL1, and GATE-16, specifi

63 ng translocation, bacterial lipoproteins are lipidated by lipoprotein diacylglycerol transferase (Lgt

64 a and mycobacteria, lipoproteins are further lipidated by lipoprotein N-acyl transferase (Lnt), to gi

65 Wnt proteins are enzymatically lipidated by Porcupine (PORCN) in the ER and bind to Wnt

66 ts, including the central Tom40 channel, are lipidated by t-2-hex in vitro and mutation of accessory

67 tilization and suggest a broader role of the lipidated C terminus in Ha-Ras biological functions.

68 :1 complex with Rab3A that requires both the lipidated C terminus of Rab3A and the presence of bound

69 we mapped the interaction site in MDFIC to a lipidated, C-terminal helix that inserts laterally into

70 Arl3 is involved in targeting and releasing lipidated cargo proteins from their carriers PDE6delta a

71 In the LIFT pathway, lipidated cargoes are transported into the cilia through

72 of polycystins, Arl13b, and Arl13b-dependent lipidated cargoes.

73 into liposomal membranes, a small library of lipidated coiled coil forming peptides was designed in w

74 hat existing membranes can be activated with lipidated coiled coil forming peptides, which might lead

75 t apoE with apoE4 lipoprotein particles less lipidated compared to apoE3 particles.

76 is lipoprotein-associated, and perhaps less lipidated, compared with apoE2 and apoE3.

77 nsity lipoprotein receptor when present on a lipidated complex.

78 -lipidated; modified), and semaglutide (mono-lipidated control; least modified).

79 s a higher membrane affinity than its doubly lipidated counterpart, or whether the affinity contribut

80 Echinocandins are a family of fungal lipidated cyclic hexapeptide natural products.

81 Membrane localization of lipidated cytosolic signaling proteins is mediated by in

82 nce-based assays indicated pore formation by lipidated DeltaCR_PrP, a variant that is known to be hig

83 We used a novel lipidated DNA-tethered APEX2 (DNA-APEX2), which upon add

84 Cotadutide (Cota) is a lipidated dual GLP-1 and Glucagon receptor agonist that

85 ucturally diverse bacterial products such as lipidated factors (lipoproteins and peptidoglycans) and

86 is requires regulated solubilization of dual-lipidated, firmly plasma membrane-associated Shh precurs

87 tical modeling, and in vitro measurements of lipidated fluorescent peptide dissociation from vesicles

88 mposition which can incorporate a variety of lipidated fluorophores and work well as fluorescence sta

89 nds to LC3 of both cytosolic form (LC3I) and lipidated form (LC3II).

90 esent study we tested whether a cell-derived lipidated form of apoE can alter neurite outgrowth in th

91 Moreover, the lipidated form of LC3, LC3-II, which triggers autophagy

92 gy-cargo protein p62/sequestosome 1, and the lipidated form of microtubule-associated protein light c

93 The lipidated form of MxiM was detected primarily in the out

94 ession of YcjN results in the formation of a lipidated form of YcjN that is posttranslationally diacy

95 demonstrate that apoA-I in lipidated or non-lipidated form prevents the formation of high molecular

96 ition to free ATG8, its membrane-associated, lipidated form was detected in many maize tissues, sugge

97 c conversion of autophagy protein LC3 to its lipidated form.

98 found that both enzymatically and chemically lipidated forms of GATE-16 and GABARAP proteins promote

99 on (NNR) measurements have been made for two lipidated forms of GlyCys, interacting with analogues of

100 Here, we develop L6-F4-2, a non-lipidated, FZD(4)-specific surrogate which significantly

101 Our data question the use of lipidated GABARAP/LC3 as the main marker of autophagic f

102 The lipidated GABARAPs bound to the Folliculin-interacting p

103 e we report for the first time the design of lipidated gamma-AApeptides as antimicrobial agents.

104 ucture reveals one membrane contact near the lipidated Ggamma C terminus and Galpha N terminus, and a

105 d to evaluate the potential of a recombinant lipidated group B meningococcal outer membrane protein P

106 an 10% of the transforming activity of fully lipidated H-Ras(61Leu) in NIH 3T3 cells.

107 n experiments revealed that LVPs were highly lipidated, had a global ultrastructure and a conformatio

108 brane rafts in cholesterol efflux applies to lipidated HDL particles but not to lipid-free apoA-I.

109 imals, is initiated by the binding of dually lipidated HH ligands to cell surface receptors.

110 lular mechanisms that have evolved to handle lipidated Hh proteins in the spatial deployment of the s

111 rst identified as a putative lipoprotein, is lipidated in vivo.

112 ally, we showed that secreted E4 is the most lipidated isoform in astrocytes, suggesting that increas

113 t p.R659* ATG7 protein lacked the ability to lipidate its LC3 substrate, leading to complete loss of

114 concentration-dependent fashion by purified lipidated K-Ras reconstituted in PtdIns(4,5)P(2)-contain

115 We also investigated the ability of NL and lipidated (L) OMP26 to induce in vitro stimulation of HE

116 nsive membrane tethering and fusion, whereas lipidated LC3 does so to a much lesser extent.

117 85 results in encapsulation of phagosomes by lipidated LC3 in multi-membrane organelles.

118 triggers LC3 recruitment on lysosomes, where lipidated LC3 interacts with the lysosomal calcium chann

119 However, while lipidated LC3 levels were elevated regardless of T4SS ac

120 ic vacuoles, an increase in the level of the lipidated LC3 protein, and the formation of autolysosome

121 Stalled endosomes become decorated by lipidated LC3, suggesting a link between noncanonical LC

122 tophagy-related proteins (BECN1, ATG5, ATG7, lipidated LC3-II, and LC3-II/LC3-I ratio) were significa

123 uces autophagy, as judged by accumulation of lipidated LC3-II, and that this induction occurs rapidly

124 C3 and are secreted within EVs enriched with lipidated LC3.

125 specificity and replaces the requirement for lipidated LC3.

126 We observed that LC3B-lipidated LDs were consistently in close proximity to co

127 Autophagy is detected by the appearance of lipidated light chain 3 (LC3) and by increases in puncta

128 c response were based on the accumulation of lipidated light chain 3 (LC3), an autophagosome marker,

129 Inactive in the membrane: Lipidated light-responsive constructs that sequester bio

130 s for the requirement of arachidonoyl PLs in lipidating lipoprotein particles.

131 e report here the development of the stable, lipidated long-acting amylin analogue cagrilintide (23)

132 d wild-type (+/+) mice were immunized with a lipidated lymphocytic choriomeningitis virus (LCMV) pept

133 We create dimeric and lipidated macrocyclic peptide conjugates as enhanced cel

134 In contrast, lipidated MAP delivered by nasal route microparticles wa

135 this work, we compare two delivery systems, lipidated MAP in PBS and encapsulation in poly(DL-lactid

136 However, whether the triply lipidated membrane anchor of H-ras has a higher membrane

137 As model systems, we chose the triply lipidated membrane targeting motif of H-ras (tH) and a l

138 l vaccine delivered by Escherichia coli as a lipidated, membrane-associated protein.

139 CD14 physically delivers these lipidated microbial products to various TLR signaling co

140 Subsequently, ATG3 lipidates microtubule-associated protein 1 light-chain 3

141 As a model system we used the lipidated minimal membrane anchor of the GTPase, N-Ras (

142 29 (mono-lipidated; modified), MEDI7219 (bis-lipidated; modified), and semaglutide (mono-lipidated co

143 We compared four peptides: J211 (non-lipidated; modified), J229 (mono-lipidated; modified), M

144 : J211 (non-lipidated; modified), J229 (mono-lipidated; modified), MEDI7219 (bis-lipidated; modified)

145 nstrated a role for both in secretion of the lipidated morphogen Hedgehog.

146 sults demonstrate the feasibility of using a lipidated multimeric peptide for mucosal immunization to

147 t RcsF has a transmembrane topology with the lipidated N terminus on the cell surface and the C-termi

148 t to be tethered to the inner leaflet by its lipidated N terminus, raising the question of how it mon

149 ed to the outer membrane bilayer through its lipidated N terminus.

150 r proteins anchored to the cell surface by a lipidated N-terminal cysteine.

151 to adopt a transmembrane orientation with a lipidated N-terminal domain on the cell surface and a pe

152 esent the application of photoswitching to a lipidated natural product, the potent proteasome inhibit

153 According to this analysis, lipidated natural products predominantly contain saturat

154 in (MTP)-negative cell line that can neither lipidate nor efficiently secrete apoB28.

155 ipid nanoreactors (PLNs) functionalized with lipidated oligonucleotides (LiNAs) that allow programmin

156 linked immunosorbent assays with recombinant lipidated OMP G1a to detect antibodies made specifically

157 y the Sec general secretory pathway and then lipidated on a conserved cysteine by the enzyme lipoprot

158 mily proteins (LC3 and GABARAP proteins) are lipidated onto single-membrane phagosomes as particles a

159 Here we demonstrate that apoA-I in lipidated or non-lipidated form prevents the formation o

160 ptides (15 mers), in various formulations as lipidated or nonlipidated multiantigenic peptides or as

161 TNF-alpha release was not induced by either lipidated or unlipidated recombinant OspA.

162 role of these disulfides in the secretion of lipidated or unlipidated truncated forms of apoB was stu

163 -defective OsATG8(G117A) or accumulating non-lipidated OsATG8 in the osatg7 mutant enhances rice dise

164 -1 human monocytic cell line and recombinant lipidated OspA (L-OspA) as the model target cell and sti

165 monocytic cell line and purified recombinant lipidated OspA (L-OspA) were used as the model target ce

166 fferent from that of prenyltransferases that lipidate other RiPPs such as cyanobactins wherein the le

167 hetes (freeze-thawed, live, or sonicated) or lipidated outer surface protein A (L-OspA) augmented the

168 -killed Borrelia burgdorferi spirochetes and lipidated outer surface protein A (L-OspA) stimulated th

169 Purified lipidated outer surface protein A (OspA), but not its un

170 human monocytes with B. burgdorferi lysate, lipidated outer surface protein A, and triacylated lipop

171 The vaccine, which is derived from a lipidated outer surface protein of the causative spiroch

172 2) ApoB:986 formed both a lipidated particle that was denser than HDL(3) and large

173 oaffinity column and was present in a poorly lipidated particle with a density between 1.19 and 1.26

174 ificantly diminished capacity to form intact lipidated particles and (ii) increased propensity to for

175 ds led to the identification of single-chain lipidated peptide agonists of RXFP1, with sub-nanomolar

176 trations, the peptide copolymerizes with the lipidated peptide and disrupts the beta-sheet secondary

177 At these lipid lengths, the N-lipidated peptide dimers exhibited strong LPS permeabili

178 We systematically designed a series of N-lipidated peptide dimers that are active against Gram-ne

179 ork was to develop a long-acting form of the lipidated peptide semaglutide that can be administered t

180 Short lipidated peptide sequences derived from various intrace

181 ic liposomes in situ, i.e., by addition of a lipidated peptide solution to plain liposomes.

182 ized by proteolytic processing (shedding) of lipidated peptide termini in vitro.

183 residues remained equally reactive when the lipidated peptide was exposed to acrolein.

184 issociation constants of binding between the lipidated peptides and serum albumin.

185 ociation constants of albumin-binding of our lipidated peptides are all very close and similar to tha

186 The monomers of lipidated peptides bind to albumin.

187 Our findings suggest that the monomeric lipidated peptides bind to HSA mainly by the fatty acid

188 Cell-penetrating lipidated peptides called pepducins target specific intr

189 such molecules, we screened approximately 50 lipidated peptides derived from the intracellular loops

190 These lipidated peptides differ in the N-terminal mutation, th

191 Complementary coiled coil forming lipidated peptides embedded in liposomal membranes are a

192 We found that these lipidated peptides form stable oligomers at concentratio

193 proach should enable the conversion of other lipidated peptides from once-weekly to once-monthly admi

194 Pepducins and other lipidated peptides have been used as both mechanistic pr

195 liposomes are prepared by mixing lipids and lipidated peptides in organic solvent (e.g., chloroform)

196 anchor is vital for the correct insertion of lipidated peptides into liposomal membranes, a small lib

197 We designed lipidated peptides that are anchored to the surface of r

198 In favorable cases, lipidated peptides were further characterized by tandem

199 These lipidated peptides--which we have termed pepducins--requ

200 abilizing internal beta-sheets formed by the lipidated peptides.

201 rent difficulties of enriching and analyzing lipidated peptides.

202 ism of the prolonged circulating duration of lipidated pharmaceutical peptides.

203 Among these, the first synthesis of a fully lipidated PIM (i.e., (16:0,18:0)(19:0/16:0)-PIM(2)) was

204 ne involves electrostatic interaction of the lipidated polybasic domain with anionic phospholipids in

205 translocation and surface expression of the lipidated polymer.

206 However, lipidated polypeptides and integral membrane proteins-an

207 ne-bound glycosyltransferases that build the lipidated polysaccharides of the mycobacterial cell enve

208 has a unique structure due, in part, to two lipidated polysaccharides-arabinogalactan and lipoarabin

209 different soluble forms of Shh from the dual-lipidated precursor is to tune cellular responses in a t

210 nism that involves proteolytic processing of lipidated precursor subunits and their subsequent polyme

211 n of both the nonlipidated substrate and the lipidated product.

212 ions by combining bespoke chemical tools for lipidated protein enrichment with quantitative mass spec

213 y, ciliary gating, intraflagellar transport, lipidated protein flagellar transport and ciliary extrac

214 Insertion of the recombinant, non-lipidated protein into artificial membranes results in b

215 Both intraflagellar transport (IFT) and lipidated protein intraflagellar transport (LIFT) pathwa

216 It is unclear how this dually lipidated protein is transported over a long range in th

217 e regulatory role of membrane composition in lipidated protein membrane targeting.

218 ied in T. brucei genome, but its function in lipidated protein transport has not been characterized.

219 p.(Gly70Glu) variant causes IRD by defective lipidated protein transport in photoreceptors and/or RPE

220 le the lipid modification was essential, the lipidated protein was more potent than a lipid-modified

221 entified CRIP1a as homologous to a family of lipidated-protein carriers that includes phosphodiestera

222 iency causes lysosomal accumulation of these lipidated proteins (major constituents of ceroid) leadin

223 the potency of membrane curvature to recruit lipidated proteins and thereby synergistically regulate

224 ables sensitive and quantitative analysis of lipidated proteins at a proteome-wide scale at native ex

225 ed recruitment to the plasma membrane by the lipidated proteins EFR3A and EFR3B.

226 Wnt proteins are secreted, hydrophobic, lipidated proteins found in all animals that play essent

227 Sorting and trafficking of lipidated proteins has traditionally been discussed in t

228 and opens avenues for the rational design of lipidated proteins in biomedical paradigms, where precis

229 l needed to biochemically characterize these lipidated proteins in specific cell types and disease st

230 Despite the abundance of lipidated proteins in the human proteome, the key determ

231 In-cell labeling of lipidated proteins is achieved by the metabolic incorpor

232 ins, as well as the discovery of unannotated lipidated proteins such as isoform-specific S-farnesylat

233 d increases the endomembrane localization of lipidated proteins that are cytoplasmic cargo in the exo

234 re synthesized as dually (N- and C-terminal) lipidated proteins that firmly tether to the surface of

235 Prions are lipidated proteins that interact with endogenous lipids

236 Pase Arl3 is important for the enrichment of lipidated proteins to primary cilia, including the outer

237 Recombinant non-lipidated proteins were purified by affinity or ion exch

238 vert these otherwise hydrophilic proteins to lipidated proteins, thus facilitating membrane associati

239 g-chain lipids (LCLs) found in membranes and lipidated proteins.

240 he capacity of membrane curvature to recruit lipidated proteins.

241 ure can in itself mediate the recruitment of lipidated proteins.

242 osition synergize to modulate recruitment of lipidated proteins.

243 ally regulate the trafficking and sorting of lipidated proteins.

244 1, respectively) are the most important apoE-lipidating proteins.

245 with PDE6 and an interaction preference for lipidated proteoforms of G proteins.

246 Analyses of the interactions of lipidated PrPs with phospholipid membranes demonstrated

247 PrP to membranes, distinct from that of non-lipidated PrPs, and influences the biochemical and confo

248 Sequential targeting of lipidated Rab28 to periciliary and ciliary membranes is

249 Synthetically lipidated recombinant green fluorescent protein (GFP) wa

250 rom HUVEC incubated with OspA lipopeptide or lipidated recombinant OspA induced chemotaxis of neutrop

251 ults were obtained with 25 nM native OspA or lipidated recombinant OspA or OspB.

252 tance resulting from the administration of a lipidated recombinant outer surface protein A (OspA) vac

253 We further show that lipidated, recombinant ApoE accurately models astrocyte-

254 p) drives this process, it is less clear how lipidated Shh solubilization from the plasma membrane is

255 ion to pressure raises the idea of a role of lipidated signaling molecules as mechanosensors, transdu

256 spectroscopically resolved substates of the lipidated signaling protein N-Ras.

257 Lipidated small GTPases and their regulators need to bin

258 structure of Escherichia coli CsgG in a non-lipidated, soluble form as well as in its native membran

259 The dually lipidated Sonic hedgehog (SHH) morphogen signals through

260 n A-I in the circulation is transported in a lipidated state and ABCA1-dependent efflux to individual

261 As a model for the lipidated state of ApoE in lipoprotein particles, we inc

262 ts of binding among the apoE isoforms in the lipidated state.

263 s proteolytic solubilization of Shh from its lipidated terminal peptide anchors.

264 The structure of the lipidated terminus dictates a unique assembly mechanism

265 factor for Alzheimer's disease (AD), is less lipidated than its corresponding AD-benign form, apoE3,

266 microarrays presenting spots of collagen and lipidated tissue factor (TF) allowed a determination of

267 -mum long patch of type I fibrillar collagen/lipidated tissue factor (TF; approximately 1 TF molecule

268 01, a synthetic TLR4 agonist, and UM-3004, a lipidated TLR7/8 agonist, within the liposomal bilayer i

269 monstrates that co-encapsulation of TLR4 and lipidated TLR7/8 agonists within the liposomal bilayer l

270 bbit following intravenous administration of lipidated TN-ApoA1.

271 the ER membrane, where it becomes partially lipidated to form a primordial intermediate.

272 g proteins that must be post-translationally lipidated to function as molecular switches in signal tr

273 ubstitution and the peptide backbone was bis-lipidated to promote MEDI7219 reversible plasma protein

274 he endoplasmic reticulum (ER) and is further lipidated to very low density lipoproteins (VLDL).

275 0-lipoproteins in ER vesicles had not become lipidated to VLDLs.

276 ome membranes, independently of ATG13/WIPI2, lipidating to PS (and PE), a molecular hallmark of CASM.

277 n in eukaryotes that is covalently attached (lipidated) to the elongating autophagosomal membrane.

278 ctive material (CRM), admixed with the novel lipidated toll-like receptor 7/8 (TLR7/8) agonist INI-40

279 treponemal lipoproteins are hydrophilic, non-lipidated TP0453 can integrate into membranes, a propert

280 and subsequent click chemistry, we obtained lipidated variants at different positions in nisin or in

281 e unconjugated hybrid peptide as well as its lipidated variants.

282 Several lipidated versions of cyclotide MCo-CVX-5c showed a sign

283 Here we show that lipidated versions of the antigens elicited significantl

284 for the reassembly of triacylglycerols that lipidate very low density lipoprotein particles as part

285 This was confirmed using lipidated vs nonlipidated hexapeptides of Borrelia outer

286 Since several of these proteins are lipidated, we hypothesized that their immunogenicity and

287 Here, we show that the lipidated Wilms tumor 1 (WT1) transcriptional corepresso

288 sively with the C terminus of RalA, which is lipidated with a prenyl group in vivo to aid membrane at

289 ion studies using RSPO ligands and a new non-lipidated Wnt analogue reveal that these ligands have qu

290 ernative initiator of Wnt signaling, and how lipidated Wnt may be produced and secreted from the cell

291 rane trafficking and secretion chaperone for lipidated Wnt signaling proteins.

292 Furthermore, these easily produced, non-lipidated Wnt surrogate agonists facilitate functional s

293 actor 1 are WNT carriers, potently releasing lipidated WNTs and forming active soluble complexes.

294 l species is critical for the extrication of lipidated WNTs from PORCN.

295 ce of cascading reactions, providing the key lipidated y-amino acid found in mutanobactin D.

296 and nonlipidated YcjN proteins suggest that lipidated YcjN aggregates in solution via its lipid moie