ライフサイエンスコーパス: lipidome

1 quantitative measurements across the diverse lipidome.

2 on leads to significant remodeling of the PM lipidome.

3 Pulmonary Disease (COPD) on the lung barrier lipidome.

4 netic clusters that characterized the plasma lipidome.

5 an LPA/S1P-mediated reprogramming of the TSC lipidome.

6 greatest similarity to the synaptic vesicle lipidome.

7 ups that collectively represent the cellular lipidome.

8 ave significant associations with the plasma lipidome.

9 accordingly the correlation with the plasma lipidome.

10 response through its impact on the platelet lipidome.

11 rences in cardiac triglyceride synthesis and lipidome.

12 nd caused qualitative changes in the hepatic lipidome.

13 high-throughput in situ profiling of the SC lipidome.

14 glycolysis and remodeling of the macrophage lipidome.

15 ing the complex molecular composition of the lipidome.

16 nvironmental influences on the ageing plasma lipidome.

17 une cells, inflammatory proteins, and plasma lipidome.

18 e to their low relative abundance within the lipidome.

19 in turn a better knowledge of the epithelial lipidome.

20 e function of the mycobacterial proteome and lipidome.

21 ection produces distinct profile in the host lipidome.

22 is required to resolve the complexity of the lipidome.

23 3PUFA mainly affected the epidermal mediator lipidome.

24 BW z-score and the umbilical cord blood (CB) lipidome.

25 dministration on the feline plasma and urine lipidome.

26 tale for free radical activity in the cell's lipidome.

27 ics and environment within the broader blood lipidome.

28 ted the phenotype to brain transcriptome and lipidome.

29 cies have been evaluated for their meibomian lipidomes.

30 ion of stomatin causes cells to change their lipidomes.

31 Here we explored the plasma lipidome (783 lipid species) in 765 children (485 diagno

32 iation study (GWAS) statistics of 179 plasma lipidomes, 791 immune cells, and PC patients of European

33 subclasses, with dramatic alterations in the lipidome across developmental stages.

34 llions of diverse molecules constituting the lipidome act as important signals within cells.

35 In this study, we thoroughly examined the lipidome adaptations of Desulfatibacillum alkenivorans s

36 ighly dynamic temporal response in the serum lipidome after IR exposure.

37 model genetically by solving M. tuberculosis lipidomes after deletion of the iron-dependent regulator

38 genase activity has a profound impact on the lipidome also beyond the class of ether lipids.

39 in AD cell models, resulting in substantial lipidome alterations which included increased esterifica

40 this effect by modulating the intracellular lipidome, altering fatty acid composition and restrictin

41 we determined the progression of the plasma lipidome among Gambian children (n = 409) and assessed i

42 We examined heritability of the plasma lipidome among healthy older-aged twins (75 monozygotic/

43 Transcriptome and lipidome analyses further highlighted dysregulation of g

44 Our lipidome analyses of Mfsd2a (-/-) retinas and outer segm

45 rformance of the PLESA approach for in-depth lipidome analysis by comparing it to conventional lipid

46 sticware use on mass spectrometry (MS)-based lipidome analysis is lacking.

47 Lipidome analysis of KSO using high-resolution mass spec

48 This study presents a comprehensive lipidome analysis of Sauvignon blanc grape juice by comb

49 The lipidome analysis revealed distinct patterns of molecula

50 liquid chromatography-mass spectrometry and lipidome analysis using (1)H nuclear magnetic resonance

51 The capability of MELDI-LC-MS in lipidome analysis was further demonstrated using the dif

52 After a comprehensive metabolome and lipidome analysis, 51 related metabolic enzymes were sel

53 results provide a holistic view between the lipidome and AD using a comprehensive approach, providin

54 itant transcriptomic measurements define the lipidome and demonstrate immediate responses in fatty ac

55 leads to perturbations in the mitochondrial lipidome and diminishes steroidogenesis.

56 were major regulators of the prostate cancer lipidome and enhanced energy production via fatty acid o

57 We evaluated plasma FA lipidome and its association with the prognosis of cirrh

58 ional maternal lipid levels influence the CB lipidome and its relationship with BW, suggesting an opp

59 to explore the influence of the grape juice lipidome and lipid metabolism in yeast on the aroma prof

60 By comparing the lipidome and metabolome compositions of various plasma s

61 CAGB bile showed significant alteration of lipidome and microbiome as indicated by multivariate par

62 zed to identify the relationship between the lipidome and PC.

63 tigate the causal association between plasma lipidome and PD risk, utilizing GWAS summary statistics

64 t curtailment of Pol I activity remodels the lipidome and preserves mitochondrial function to promote

65 Our findings indicate that the lipidome and proteome of subjects who report PEs at 18 y

66 A study of the lipidome and proteome was performed on milk fat globule

67 relations of apolipoproteins with the plasma lipidome and proteome.

68 otein levels and rs398122988 with the plasma lipidome and related phenotypes, identifying novel assoc

69 ns and drives AD-relevant alterations in the lipidome and single-cell transcriptome, particularly in

70 determinant of global changes in the hepatic lipidome and suggest the hypothesis that these actions c

71 l overlap in the genetic basis of the plasma lipidome and T2D-related traits.

72 that our understanding of the composition of lipidome and the function of lipids is incomplete.

73 Informatic analyses of the lipidome and transcriptome indicated alterations of the

74 Here we present the integrated metabolome, lipidome and transcriptome of human adult HSPCs (lineage

75 d time-dependent responses of the macrophage lipidome and transcriptome to 25OHC treatment.

76 disease by covering a greater portion of the lipidome and using annotation which does not over-report

77 dicate an intimate coupling between cellular lipidomes and glycomes.

78 ly integrating time-resolved transcriptomes, lipidomes and metabolomes in response to nitrogen depriv

79 Here, we measured the lipidomes and transcriptomes of individual human dermal

80 il to current understanding of the zebrafish lipidome, and could aid in the elucidation of structure-

81 Here, we analyzed the transcriptome, lipidome, and genetic interactions of human leukemia cel

82 ltaneous spatial analysis of the metabolome, lipidome, and glycome from a single tissue section using

83 and oxidative stress, improved the maternal lipidome, and prevented maternal leptin resistance.

84 ell cycle by using live single-cell imaging, lipidome, and transcriptome analysis of a non-transforme

85 age- and region-specific changes in the lens lipidome, and we evaluate recent research efforts to uti

86 used mass spectrometry to map the proteomes, lipidomes, and metabolomes of 174 yeast strains, each la

87 nal proteome strategy along with the shotgun lipidome approach for the identification of active SHs,

88 lipidome distinctly; (2) female fetal heart lipidomes are more sensitive to maternal obesity than ma

89 their pathophysiology, highlighting the lens lipidome as a potential therapeutic target.

90 eloxicam altered the feline plasma and urine lipidome as demonstrated by multivariate statistical ana

91 male individuals suggesting a healthy plasma lipidome as resource for early biomarker discovery.

92 eding at the levels of the transcriptome and lipidome as well as metabolic fluxes, providing evidence

93 Analysis of the lipidome associated with nsLTPs showed a wide variety of

94 to describe the serum metabolome (including lipidome) associated with acute TBI within 24 h post-inj

95 tware version 4 (MS-DIAL 4), a comprehensive lipidome atlas with retention time, collision cross-sect

96 -OHOA), an antitumor compound, on xenografts lipidome based on IMS.

97 nant analysis Q(2)(Y) of 0.728] in the fecal lipidome between participants with normal blood glucose

98 ids present in low relative abundance in the lipidome but play crucial roles in mitochondrial metabol

99 ause of the great diversity exhibited in the lipidome, but no automated lipid classification exists t

100 to obtain detailed information on the whole lipidome, but the reliable quantitation of multiple lipi

101 matrices providing a deeper analysis of the lipidome by IMS.

102 ificance, it is not yet resolved if specific lipidome changes drive vacuole phase separation.

103 ng alveoli), selective proteome and possible lipidome changes have been noted.

104 How lipidome changes support CD8(+) effector T (T(eff)) cell

105 ith disease, indicating the relevance of the lipidome changes to disease progression.

106 We report that the lipidome changes with the cell cycle.

107 Detailed lipidome characterization for single cells is still far

108 pids, we quantitatively targeted >150 plasma lipidome components in age- and body mass index-matched,

109 urt manufacturing - on some health-promoting lipidome components in milk from two feeding treatments

110 espite their low relative abundance, CLs are lipidome components that perform vital biological functi

111 f concept, we employed sUHR to determine the lipidome composition and fluxes of 62 nitrogen-containin

112 Here we investigated the lipidome composition of prefrontal cortex gray matter in

113 All three diseases alter the brain lipidome composition, leading-among other things-to a co

114 with alterations in SL enzyme expression and lipidome composition.

115 However, quantifying lipidomes comprehensively in a high-throughput manner re

116 The human lipidome comprises over tens of thousands of distinct li

117 ipids is very challenging due to the complex lipidome comprising several hundred individual compounds

118 Analysis of the host lipidome confirmed that symbiosis establishment was acco

119 ion determined circulating plasma fatty acyl lipidome content.

120 e inter-individual variability in the plasma lipidome contributes to the genetic basis of T2D is unkn

121 Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabo

122 uisition (DIA) has the potential to increase lipidome coverage, as it enables the continuous and unbi

123 These lipidome data were generated by a newly developed biomol

124 ed on highly corresponding transcriptome and lipidome data.

125 RV bronchiolitis, we analyzed nasopharyngeal lipidome data.

126 effect of herbicide atrazine on the algae's lipidome, demonstrating molecular changes in glycerol li

127 In contrast, ASD lipidome differences were accounted for by dietary diffe

128 Here, we found that LD lipidomes display a remarkable increase in TAG acyl chai

129 Here, we combine experimental lipidome dissection with multi-scale modeling to investi

130 obesity affects the maternal and fetal serum lipidome distinctly; (2) female fetal heart lipidomes ar

131 Eggert et al. explore the dynamics of the lipidome during cell division and provide new insights o

132 , documented alteration in the mycobacterial lipidome during cellular infection and/or drug treatment

133 rometry (LC-MS/MS) to investigate the murine lipidome during normal postnatal lung development.

134 Furthermore, we investigated the signaling lipidome during platelet activation, identifying numerou

135 e classified dynamic changes in the maternal lipidome during pregnancy and identified lipids associat

136 rometry-based lipidomics to map the mediator lipidome during the transition from inflammation to reso

137 The size of the putative lipidome far exceeds the number currently classified, de

138 discriminate between common and durum wheat lipidome for an authenticity purpose was explored.

139 s, for the first time, thus categorizing the lipidome for future MALDI-MSI studies of pulmonary disea

140 lipids and small molecules that constitute a lipidome for Mycobacterium tuberculosis.

141 Here, we solved lipidomes for the four human CD1 antigen-presenting mole

142 ase activity, without changing (sub)cellular lipidome fractions, which suggests a local function of S

143 tudy addresses temporal changes in the serum lipidome from 4 h to 28 d in nonhuman primates (NHPs) wi

144 LVPs lipidome from four patients was determined via electrosp

145 ogical relevance, CLAW-MRM integrates LIGER (lipidome gene enrichment reactions), linking lipid expre

146 al intracellular biochemical composition and lipidome hallmarks-lipid concentration and unsaturation

147 ; however, characterisation of the zebrafish lipidome has not been as comprehensive.

148 omarkers including cord serum metabolome and lipidome, human leukocyte antigen (HLA) genotype, infant

149 irst) by unsupervised clustering of temporal lipidome, identifying a subgroup of children having earl

150 anellar interfacing, to propose 'subcellular lipidome imbalance' as a likely common pathomolecular th

151 lood mononuclear cells including metabolome, lipidome, immunome, proteome, and transcriptome from 36

152 We performed a genetic study of the human lipidome in 1212 individuals from 42 extended Mexican Am

153 Here we investigated the peripheral lipidome in 958 children and adolescents with overweight

154 In this study, we investigated the change in lipidome in a mouse model with unilateral ureteral obstr

155 tionally-driven rebuilding of their membrane lipidome in a pattern preserving the overall saturation/

156 In this study, we aimed to determine if the lipidome in AD is universal across non-Hispanic White an

157 little is known about the role of the airway lipidome in between-virus heterogeneity and disease seve

158 tify the dynamic patterns in the circulating lipidome in critically ill humans.

159 Here, we studied umbilical cord serum lipidome in infants who later developed T1D (N = 33); in

160 characterized the nuclear and mitochondrial lipidome in mouse liver throughout the day, upon differe

161 Dynamics of the human skin mediator lipidome in response to dietary omega-3 fatty acid suppl

162 g of dynamic reconfiguration of the cellular lipidome in response to mild nitroxidative stress.

163 Here, we used UPLC/TOF-MS to survey the lipidome in SOD1(G86R) mice, a model of ALS.

164 We report the archaeal lipidome in SPM from diverse oceanic regimes.

165 eding had a significant impact on the plasma lipidome in the first year of life, with up to 17-fold i

166 An altered lipidome in tumors may affect not only tumor cells thems

167 study, we characterized the liver and plasma lipidomes in patients with early ALD.

168 uantitative mass spectrometry to define the "lipidome" in prostate tumors with matched benign tissues

169 ling of unsaturation patterns within complex lipidomes including human plasma.

170 preterm birth negatively affected colostrum lipidome, including 5-PAHSA levels, but the lipidomic pr

171 ese risk factors pathologically disrupts the lipidome, including immunomodulatory eicosanoid and doco

172 l's effect on remodeling the LD proteome and lipidome, including post-translational modifications.

173 Methods expanding coverage of the lipidome increase the likelihood of biomarker discovery

174 ociated with the model and altered the serum lipidome, independently of GLP-1 secretion.

175 implify the process and interrogate a larger lipidome into a single analysis.

176 ences reduce the dimensionality of the human lipidome into clusters that are associated with risk fac

177 l lipid species, we investigated whether the lipidome is genetically redundant and whether its geneti

178 Cellular lipidome is highly regulated through lipogenesis, render

179 reported, characterization of changes in the lipidome is lacking.

180 The human lipidome is made up of thousands of ubiquitous lipid spe

181 Furthermore, we show that the skin bioactive lipidome is significantly altered during inflammation an

182 o and citric acid metabolites as well as the lipidome, linking these metabolomic changes independentl

183 , we show that during Pi restriction the Mtb lipidome markedly remodels such that phospholipids are r

184 f data that can be detected within mammalian lipidome mass spectrometry imaging (MSI) via matrix-assi

185 .Conclusions: This insight into the alveolar lipidome may provide monitoring tools and lead to new th

186 that both proteins are necessary for retinal lipidome membrane organization, visual function, and to

187 It is challenging to capture the transient lipidome/metabolome from cells in a native tissue enviro

188 between proteins and ligands, we define the lipidome/metabolome in contact with membrane porins and

189 PCSCs have specific and common proteome and lipidome modulations.

190 s research highlights the value of screening lipidome mutants to identify appropriate hosts for engin

191 not known why cells synthesize such diverse lipidomes, nor what regulates their metabolism.

192 In the kidney lipidomes obtained from the UUO 7 days group compared to

193 In this study, we analyzed the lipidome of 40 adults with PTSD and 40 trauma-exposed no

194 ry to provide a comprehensive picture of the lipidome of Aedes aegypti (Aag2) cells infected with Wol

195 this hypothesis, we analyzed the fatty acyl lipidome of AF by liquid chromatography-mass spectrometr

196 Characterization of the lipidome of B. thetaiotaomicron OMVs revealed enrichment

197 based approach was employed to determine the lipidome of brain tissues affected by AD.

198 ferentially affected the brain and brown fat lipidome of control and P301S mice, preventing lipid vac

199 gical behavior and quantitative proteome and lipidome of cyanobacterial LDs of Synechocystis sp. PCC

200 In the present study the lipidome of fine-flavor cocoa fermentation was analyzed

201 d analysis allowed a clear separation of the lipidome of fish from polluted and reference sites; phos

202 We then compared the lipidome of loa1Delta mutant and wild-type strains.

203 port data and predictions of the periprotein lipidome of Lyp1 support a new model in which a narrow b

204 Here we examined the brain lipidome of mice across their lifespan using untargeted

205 However, the plasma lipidome of NAFLD and whether NASH has a distinct plasma

206 Analyses of the cecal metagenome and lipidome of PAHSA-treated mice identified multiple lipid

207 ctrometry unveiled substantial shifts in the lipidome of pigmented rice sprouts, showcasing a notable

208 pproaches have been developed to profile the lipidome of plants with increasing chemical and spatial

209 and transcriptomics, we link changes in the lipidome of proliferating hepatocytes to altered metabol

210 Here we quantify the comprehensive lipidome of rat synaptic membranes during postnatal deve

211 The cellular lipidome of RAW264.7 was markedly changed in a parallel

212 nol to activate lipolysis and the fatty acyl lipidome of released lipids was determined by using LC-M

213 In this work, we contrasted the polar lipidome of Salicornia ramosissima and Halimione portula

214 We profiled the anther lipidome of seven genotypes exposed to ambient temperatu

215 rane viscosities, that reflect the change in lipidome of the cells following differentiation.

216 eal the detailed composition of the membrane lipidome of the model strain Synechococcus sp. WH7803 an

217 While profiling the lipidome of the mouse brain by mass spectrometry, we dis

218 id molecules that collectively represent the lipidome of the respective tissue.

219 HRMS) to characterize for the first time the lipidome of the skeletal muscle of two fish species (Bar

220 Information on the lipidome of these crickets with high commercial value is

221 In exploring the lipidome of various living systems, novel lipids are bei

222 on the other hand, was vastly different from lipidomes of all other tested species.

223 with mass spectrometry were used to evaluate lipidomes of all tested species.

224 In this exploratory study, lipidomes of blood and breast milk from Suffolk sheep an

225 APOE4, but not APOE3, disrupted the cellular lipidomes of human induced pluripotent stem cell (iPSC)-

226 However, the phytochemicals and lipidomes of Kainth Seed Oil (KSO) are still scarce.

227 into the inter-relationships between complex lipidomes of mammalian membranes, the membrane physicoch

228 vide a comprehensive characterization of the lipidomes of primary rat HSCs during 17 days of activati

229 shotgun mass spectrometry, we determined the lipidomes of the host Madin-Darby canine kidney cell, it

230 e the high-throughput analysis of a cellular lipidome on a large scale directly from the extracts of

231 The rabbit meibomian lipidome, on the other hand, was vastly different from l

232 ss did not significantly impact the cellular lipidome or triacylglycerol accumulation in the context

233 ues are necessary to cover the full range of lipidomes, owing to their limited molecular polarity ran

234 ion, and undergo marked remodelling of their lipidome, particularly a reduction in long chain triglyc

235 ss also induced a pronounced reallocation of lipidome peak area to triacylglycerols.

236 alized for bronchiolitis, the nasopharyngeal lipidome plays an important role in the pathophysiology

237 e biphasic and dynamic response to the serum lipidome post-irradiation emphasize the importance of de

238 ll three matrices exhibited a characteristic lipidome profile which was affected differently by five

239 Global lipidome profiles also highlighted broader changes direc

240 By drawing upon existing plasma lipidome profiles and genomic data we conducted analyses

241 In this study, we used histology, lipidome profiling (UHPLC-MS), and transcriptomic analys

242 In this study, transcriptome and lipidome profiling of triple negative breast cancer cell

243 emonstrate a new method for comprehensive FS lipidome profiling with the use of LC-Q-TOF-MS and dispe

244 Genetic architecture of plasma lipidome provides insights into regulation of lipid meta

245 e scope, accuracy, and dynamic range of full-lipidome quantitative shotgun profiling.

246 Children's plasma metabolome, especially lipidome, reflects gene regulation and dietary exposures

247 stematic comparison of thousands of distinct lipidomes remains challenging.

248 n mechanism for membrane homeostasis wherein lipidome remodeling in response to dietary lipid inputs

249 This suggests an essential role for lipidome remodeling in viral replication.

250 r/ester bonds, yet the complexities of their lipidome remodeling under varying physicochemical and nu

251 able to ferroptosis through subtype-specific lipidome remodeling.

252 mbined interrogation of the HDL proteome and lipidome revealed a distinct cluster of PCSK9, phospholi

253 Analysis of the CRC lipidome revealed a robust TG-species signature with pro

254 The platelet lipidome revealed an altered lipid profile in mildly hyp

255 The proteome, lipidome, RNA content, and carbohydrate composition of E

256 phosphate scarcity profoundly influenced the lipidome's composition, leading to an enhanced diversity

257 The lipidome-scale data highlight the dynamic, light-driven

258 Therefore we concluded that the lipidome should be considered an important component of

259 es, (ii) examine the relative changes in the lipidome signal and the gene expression patterns of the

260 ural space models and subsequently computing lipidome similarities.

261 Given these findings through a time-varied lipidome status, the present study provided valuable ins

262 f compounds that comprise the integrated CD1 lipidome supports the ongoing discovery of lipid blocker

263 Epilipids, a subset of the lipidome that comprises oxidized, nitrated, and halogena

264 ially disease-specific shift in their plasma lipidome that correlates with disease severity and syste

265 need to understand environmental impacts on lipidomes, the lipid specificity of cell functions, and

266 induced some significant 1-y changes in the lipidome, they were not significantly associated with su

267 of CD1 protein differentially edits the self-lipidome to show distinct capture motifs based on lipid

268 each individual's proteome, metabolome, and lipidome, to short or long-term exposure to different pC

269 anges in peanut (Arachis hypogaea L.) anther lipidome under heat stress (HT) will aid in understandin

270 ornutum maintained more than 92% of its core lipidome under oxidative stress, patterns in biomarker d

271 Lipidomes undergo permanent extensive remodeling, but ho

272 uch as mass spectrometry, cannot investigate lipidomes until they are extracted, and thus they cannot

273 Here, changes in the lipidome upon different animal diets were addressed by s

274 owth, photosynthetic capacities and membrane lipidome variations.

275 Particularly, the lipidome varied over time, demonstrating the temporally

276 gically normal conditions, but how a healthy lipidome varies within the population is poorly understo

277 used metabolomics to test if the cord-blood lipidome was affected in children diagnosed with type 1

278 nretinide on insulin action and the cellular lipidome was assessed in a number of lipid-challenged mo

279 Under AT and HT, the lipidome was dominated by phosphatidylcholine (PC), phos

280 In this observational study, plasma FA lipidome was investigated in 51 cirrhotic patients befor

281 In the brain tissue of all three models, the lipidome was more influenced than the metabolome.

282 of the LPS administration on metabolome and lipidome was negligible.

283 examine the effect of the diet on the brain lipidome, we performed Shotgun Lipidomics.

284 s in both cardiac triglyceride synthesis and lipidome were abolished during obesity.

285 Shifts in the maternal and CB lipidome were consistent with the selective transport of

286 Plasma and urine lipidome were determined by LC-MS before the first treat

287 also find that GPMVs have slightly different lipidomes when isolated from cells adapted for growth at

288 Ergosterol is depleted from this periprotein lipidome, whereas phosphatidylserine is enriched relativ

289 minor lipid classes in the hepatic cellular lipidome, which collectively represent >80% of the total

290 lidated lipidomics platform to map the fecal lipidome, which integrates unique information about host

291 match to humans in terms of their meibomian lipidomes, while canines were the second closest species

292 y compensated both in culture and in vivo by lipidome-wide remodeling, most notably upregulation of s

293 unprecedented diversity of the thaumarchaeal lipidome with 118 different lipids suggests that membran

294 ic alteration(s), typified by changes in the lipidome with corresponding upregulation of lipid metabo

295 Aging affects 14% of the brain lipidome with late-life changes starting predominantly a

296 t- and season-induced variations in the milk lipidome with many odd chain triacylglycerides upregulat

297 Modulating the T-cell lipidome with polyunsaturated fatty acids impaired the p

298 ted with profound alterations in the hepatic lipidome with significant reductions in both desaturatio

299 elationship between infection and metabolome/lipidome, with hsCRP generally mediating a lower proport

300 of the structure and function of lipids (the lipidome) within a living system.