ライフサイエンスコーパス: lipocalin 2

1 olate siderophore, binds to the host protein lipocalin 2.

2 and inflammatory molecules interleukin-6 and lipocalin 2.

3 adipocyte UCP1 expression via the mammokine lipocalin 2.

4 ounter-regulated by the presence of iron and lipocalin 2.

5 h a striking structural resemblance to human lipocalin 2.

6 IL-1beta and IL-17 also individually induce lipocalin 2.

7 , including activin A, myostatin, GDF15, and lipocalin-2.

8 %; 95% confidence interval [CI]: 24%, 127%), lipocalin 2 (659%; 95% CI: 198%, 1838%), and regeneratin

9 (neutrophil gelatinase-associated lipocalin/lipocalin 2), a secreted glycoprotein that binds to MMP-

10 ain Salmonella by promoting the induction of lipocalin 2, a host antimicrobial factor that inhibits b

11 s survival advantage is counter-regulated by lipocalin 2, a siderophore-binding host protein, which r

12 Lipocalin 2 action was enhanced by iron-siderophore.

13 eptor (Mc4r) by cotreating mice with Flx and lipocalin 2, an anorexigenic hormone signaling through t

14 Lipocalin 2, an iron-siderophore-binding protein, conver

15 osterone system (RAAS) activation, and serum lipocalin 2 and biomarkers of inflammation and cardiac s

16 d inflammation as evidenced by reduced fecal lipocalin 2 and colon pro-inflammatory cytokines/chemoki

17 Lipocalin 2 and galectin 3, two biomarkers of diabetes c

18 We found lipocalin 2 and numerous other innate defense genes to b

19 skin lesions, protein and mRNA expression of lipocalin 2 and other innate defense genes (hBD2, elafin

20 an overcome metal ion starvation mediated by lipocalin-2 and calprotectin via alternative pathways, I

21 ression of antimicrobial proteins, including lipocalin-2 and calprotectin, which sequester essential

22 hil recruitment and down-regulating elevated lipocalin-2 and cathepsin D expression.

23 significantly correlated with the levels of lipocalin-2 and IL-17A in the serum.

24 tion (vcam-1, s100A9, and Il-1b) and injury (lipocalin-2 and kim-1), neutrophils significantly contri

25 l ADC decrease and elevated plasma levels of lipocalin-2 and microRNA-150, was associated with a fata

26 ated adipocytes-namely, coenzyme A synthase, lipocalin 2, and cortactin.

27 xpressed at the RNA level (TFF1, TFF2, TFF3, lipocalin 2, and galectin 3) showed a good concordance b

28 eries of the roles of ferroportin, hepcidin, lipocalin 2, and members of the six transmembrane epithe

29 F9, IL-6, IL-19, CCL20, S100A7/A8/A9, DEFB4, lipocalin 2, and peptidase inhibitor 3 (p < 0.05), indic

30 IL-1ra, IP-10, SAP, cortisol, lipocalin 2, and resistin were higher, while ghrelin, T3

31 The relationship between TMPO-AS1, Lipocalin 2, and SFPQ were identified and validated by R

32 s well gender-neutral (H19 fetal liver mRNA, lipocalin 2, and ubiquitin D) genes.

33 trations of serum amyloid A, haptoglobin and lipocalin-2, and administration of AO postbiotic did not

34 g others suppressor of cytokine signaling-3, lipocalin-2, and alpha1-antichymotrypsin.

35 id-A3, chemokine ligands (Ccl2, Ccl7, Ccl9), lipocalin-2, and matrix metalloproteinase-3 and -12 of i

36 idermal skin, including loricrin, filaggrin, lipocalin-2, and Melan-A positive cells.

37 Lipocalin 2 antagonized these effects at a point upstrea

38 ed by the immobilization of rabbit polygonal lipocalin-2 antibody on gold nanoparticles attached on g

39 Our results also identified lipocalin 2 as a contributor to renal inflammation and a

40 These data characterize lipocalin 2 as an epithelial inducer in Ras malignancy a

41 m of MMA-associated kidney disease, identify lipocalin-2 as a biomarker of increased oxidative stress

42 sion of the IL-17 target genes IL-6 and 24p3/lipocalin-2 as a readout, functional reconstitution of s

43 Finally, we identify lipocalin-2 as the key secreted factor downstream of Tcf

44 dentified an acute phase response gene, 24p3/lipocalin 2, as a novel IL-17-induced gene.

45 Conversely, targeting the NUPR1-lipocalin-2 axis is detrimental to young alveolar cells

46 Genetic inactivation of the NUPR1-lipocalin-2 axis or iron supplementation rescues stemnes

47 We demonstrate that similar to lipocalin 2, Bet v 1 is capable of binding iron via cate

48 d hypomethylated genes (trefoil factor 2 and lipocalin 2) between pancreatic and breast cancer cell l

49 is less accessible to host sequestration by lipocalin-2 but can be "re-acquired" by Salmonella, allo

50 Elevated fecal lipocalin-2, calprotectin, IgG levels, and dysbiosis sup

51 ion of biomarkers, including K16, Ki67, CD3, lipocalin-2, CD11c, dendritic cell lysosome-associated m

52 We found that lipocalin 2 could also convert 4T1-Ras-transformed mesen

53 ion of IL-1beta alone could reconstitute the lipocalin 2 deficiency in TLR4 knockout animals and resc

54 Lipocalin 2-deficient animals have impaired lung bacteri

55 observed to be Dectin-1 and IL-22 dependent, lipocalin 2-deficient mice did not demonstrate impaired

56 phimurium is unaffected by E. coli Nissle in lipocalin 2-deficient mice.

57 (+) T, CD11c(+), and IL-36gamma(+) cells and lipocalin-2-expressing cells.

58 CD3(+) T, CD11c(+), and IL-36y(+) cells and lipocalin-2-expressing cells.

59 that STAT1 is required for IFNgamma-induced lipocalin-2 expression in murine adipocytes.

60 ion of Tfrc (transferrin receptor) and Lcn2 (lipocalin 2)), facilitate glucose import (e.g. Hk2 (hexo

61 8; CCL20/FCH, 8.36; PI3 [elafin]/FCH, 15.40; lipocalin 2/FCH, 6.94, human beta-defensin 2 [DEFB4A]/FC

62 d in classical pancreatic carcinomas such as lipocalin 2, galectin 3, claudin 4, and cathepsin E.

63 s that are produced by the kidney, including lipocalin-2, glycerol 3-phosphate, 1-acyl lysophosphatid

64 Lipocalin 2, haptoglobin, serum amyloid A3, stearoyl-CoA

65 These findings demonstrate that lipocalin 2 has at least two functions related to tumori

66 (C5) that secretes relatively high levels of lipocalin 2 (human NGAL) induced suppression of hematopo

67 cornea and, in the conjunctiva, sPLA(2)-IIA, lipocalin 2, IGFBP3, multiple MCH class II proteins, and

68 Skin-infiltrating CD8(+) T cells produced lipocalin-2 in a drug-specific manner, which triggered t

69 atic inflammation-related proteins including lipocalin-2 in db/db mice were attenuated by CR.

70 NA) antibodies up-regulate the expression of lipocalin-2 in glomerular mesangial cells.

71 g/ml, IQR 0-11.1; n = 14), urinary levels of lipocalin-2 in SLE patients were significantly higher (n

72 ption factor NUPR1 and its downstream target lipocalin-2 in the cell of origin in mice and humans, wh

73 NA antibodies promote the local secretion of lipocalin-2 in the kidneys of patients with systemic lup

74 The presence of lipocalin-2 in the urine of patients with LN correlated

75 We conclude that lipocalin 2 is a crucial component of mucosal immune def

76 inct at the molecular level and suggest that lipocalin 2 is a new therapeutic target for breast cance

77 Lipocalin 2 is highly expressed in the lung where it exe

78 In this study, we found that lipocalin 2 is rapidly and robustly induced by Klebsiell

79 These findings indicate that urinary lipocalin-2 is a potential marker of the presence and se

80 One of these genes, lipocalin 2, is a putative in vivo estrogen target gene

81 Lipocalin 2 (LCN-2) is an innate immune protein that is

82 explored the role of a bone protein known as lipocalin-2 (LCN-2) in the connection between periodonti

83 Lipocalin-2 (LCN-2) is an osteokine that suppresses appe

84 helial-derived antimicrobial factors such as lipocalin-2 (LCN-2), a protein that specifically inhibit

85 usly secretion of the iron chelating protein lipocalin 2 (LCN2) and protons, which acidify the urine.

86 ermore, neuronal A1R promoted the release of lipocalin 2 (Lcn2) and resulted in astrocyte activation.

87 We have previously identified lipocalin 2 (Lcn2) as a cytokine playing a critical role

88 We identified lipocalin 2 (Lcn2) as a gene induced by dexamethasone an

89 We have recently characterized the role of lipocalin 2 (Lcn2) as a new adipose-derived cytokine in

90 Here, we identify lipocalin 2 (lcn2) as an inducible factor that is secret

91 ough molecular and genetic analyses in mice, lipocalin 2 (LCN2) as an osteoblast-enriched, secreted p

92 We identified lipocalin 2 (LCN2) as both a marker of deactivated macro

93 hils rely on the siderophore-binding protein lipocalin 2 (Lcn2) in a "tug-of-war" for iron.

94 Lipocalin 2 (LCN2) is a novel adipokine that negatively

95 Lipocalin 2 (LCN2) is a pleiotropic molecule that is ind

96 The innate immune protein lipocalin 2 (Lcn2) is able to specifically bind Ent and

97 We have previously demonstrated that lipocalin 2 (LCN2) is an innate immunity protein that bi

98 how that a mutant form (K3Cys) of endogenous lipocalin 2 (LCN2) is filtered by the kidney but can byp

99 Here, we report that lipocalin 2 (Lcn2) promotes breast cancer progression, a

100 Lipocalin 2 (LCN2) regulates infection response and incr

101 Secreted lipocalin 2 (Lcn2) sequesters the Escherichia coli sider

102 Lipocalin 2 (LCN2) was recently identified as an endogen

103 Upregulation of S100A8, S100A9, and lipocalin 2 (LCN2) were confirmed by Western blots, and

104 the tumor led to an increased expression of lipocalin 2 (LCN2), a host protein that can sequester th

105 at tNLGs mediate a potent CRISPR knockout of Lipocalin 2 (Lcn2), a known breast cancer oncogene, in h

106 Lipocalin 2 (Lcn2), a member of the lipocalin family, is

107 In this study, we report that lipocalin 2 (Lcn2), a recently characterized adipokine/c

108 d the potential of cerebrospinal fluid (CSF) lipocalin 2 (LCN2), a secreted glycoprotein that has bee

109 iche promotes the release of STAT3-activated lipocalin 2 (LCN2), a secretory glycoprotein from the N2

110 Lipocalin 2 (LCN2), a siderophore-binding protein, is in

111 ulating levels of the secreted glycoprotein, lipocalin 2 (Lcn2), an adipokine previously associated w

112 Lipocalin 2 (Lcn2), an innate immune protein, has emerge

113 s-including kidney injury molecule-1 (Kim1), lipocalin 2 (Lcn2), and keratin 8 (Krt8)-and of several

114 However, Ent is bound by the host protein lipocalin 2 (Lcn2), preventing bacterial reuptake of afe

115 oprotection markers, including COX-2 itself, lipocalin 2 (LCN2), tissue inhibitor of metalloproteinas

116 ation of Est led to the hepatic induction of lipocalin 2 (Lcn2), whereas ablation of Lcn2 abolished t

117 gainst K. pneumoniae, which was dependent on lipocalin 2 (LCN2).

118 Lipocalin 2 (Lcn2; 24p3; neutrophil gelatinase-associate

119 Lipocalin 2 (LCN2; also known as NGAL) is a secreted gly

120 ine and secreting the bacteriostatic protein lipocalin 2 (LCN2; also known as NGAL).

121 Lipocalin 2 (Lcn2; siderocalin, 24p3) plays a central ro

122 n was associated with PAMP translocation and lipocalin-2 (LCN2) and chemokine (C-X-C motif) ligand 1

123 hin the CSF express the iron-binding protein lipocalin-2 (LCN2) and its receptor SCL22A17.

124 n this article, we show that blood levels of lipocalin-2 (LCN2) and serum amyloid A (SAA) levels are

125 he antimicrobial siderophore-binding peptide Lipocalin-2 (Lcn2) are observed in inflammatory bowel di

126 tation (allo-HCT) to investigate the role of lipocalin-2 (LCN2) as a newfound regulator of intestinal

127 and vehicle-treated DIO mice, we identified lipocalin-2 (Lcn2) as the gene most strongly upregulated

128 ich immunoassay (IA) was developed for human lipocalin-2 (LCN2) by functionalizing a KOH-treated poly

129 Lipocalin-2 (LCN2) emerged as a relevant adipokine invol

130 Unexpectedly, the lipocalin-2 (Lcn2) gene, which encodes neutrophil gelati

131 Lipocalin-2 (Lcn2) is a biomarker for many inflammatory-

132 Here, we show that lipocalin-2 (Lcn2) is a key regulator of hepatic SR-BI,

133 Lipocalin-2 (LCN2) is a secreted protein involved in tra

134 Lipocalin-2 (LCN2) is an acute-phase secretory molecule

135 Lipocalin-2 (Lcn2) is an innate immune protein elevated

136 Lipocalin-2 (LCN2) is secreted from adipocytes, and its

137 thelicidin antimicrobial protein (Camp), and lipocalin-2 (Lcn2) mRNA expression giving rise to cells

138 Lipocalin-2 (LCN2) promotes malignant development in man

139 In the mouse, the osteoblast-derived hormone Lipocalin-2 (LCN2) suppresses food intake and acts as a

140 Lipocalin-2 (LCN2) was originally isolated from human ne

141 over 100 different cytokines, we found that Lipocalin-2 (LCN2) was the most substantially elevated p

142 ong fecal biomarkers, myeloperoxidase (MPO), Lipocalin-2 (LCN2), and 16S rRNA gene sequencing were me

143 SubAB induces expression of a novel form of Lipocalin-2 (LCN2), and describe its biological activity

144 FABP), trefoil factor-3 (TFF3), lactoferrin, lipocalin-2 (LCN2), and mucin-2, have been reported as i

145 -2), inducible nitric oxide synthase (Nos2), lipocalin-2 (Lcn2), MIP-1alpha, MIP-1beta, and keratinoc

146 mmatory environment via the up-regulation of lipocalin-2 (LCN2), vascular endothelial growth factor (

147 levels of a specific inflammatory cytokine, lipocalin-2 (LCN2), were elevated in the plasmas of pati

148 ples clustered on the basis of expression of lipocalin-2 (LCN2), with samples characterized by high L

149 single-cell RNA sequencing, we identified a lipocalin-2 (LCN2)-expressing neutrophil population in m

150 docrine function of bone that is mediated by Lipocalin-2 (LCN2).

151 ells exposed to the SASP strongly upregulate Lipocalin-2 (LCN2).

152 t, by regulating the proinflammatory protein lipocalin-2 (Lcn2).

153 regulated factors is the acute phase protein lipocalin-2 (LCN2).

154 nonconvertors, multiprotein panels including lipocalin 2, lectin-like oxidized low-density lipoprotei

155 ukemic mice and CML patients showed elevated lipocalin 2 levels compared with healthy individuals.

156 Lipocalin 2 levels increased with RAAS activation compar

157 ly diagnosed dermal tunnels had higher serum lipocalin-2 levels compared with those without tunnels.

158 Protein S100A8/A9 and lipocalin-2 levels were also increased in platelets, sug

159 Among SLE patients, urinary lipocalin-2 levels were significantly higher in those wi

160 Lipocalin 2 (Lpc-2) was the best protein biomarker of se

161 Lipocalin 2 may be important in modulating aldosterone-i

162 rtened colons, and increased fecal levels of lipocalin 2), metabolic syndrome, and an inability to cl

163 bulin, ceruloplasmin, complement components, lipocalin-2, metallothionein, serine protease inhibitor-

164 that use catecholate-type siderophores, and lipocalin 2(-/-) mice are highly susceptible to infectio

165 rritin, Fibrinogen, Haptoglobin, Hemoglobin, Lipocalin-2, MMP-12, MMP-9, Myeloperoxidase, PGRP-S, Pro

166 previous studies indicate that reduction of lipocalin 2 (mouse 24p3) expression by either anti-sense

167 bial protein siderocalin (SCN; also known as lipocalin 2, neutrophil gelatinase-associated lipocalin/

168 Recently, the secreted protein 24p3 (lipocalin-2, neutrophil gelatinase-associated lipocalin

169 bial protein siderocalin (SCN; also known as lipocalin-2, neutrophil gelatinase-associated lipocalin,

170 tubular damage, manifested by production of lipocalin-2, occur later in the disease process.

171 pression of kidney injury marker genes, like lipocalin-2 or kidney injury molecule-1.

172 Although lipocalin 2 production was observed to be Dectin-1 and I

173 in this model and mucosal reconstitution of lipocalin 2 protein in these animals resulted in rescue

174 pus erythematosus (SLE), and whether urinary lipocalin-2 represents a marker of kidney involvement in

175 Importantly, exogenous lipocalin 2 rescued viral exacerbation of S. aureus infe

176 e neutrophil peptides cathelicidin LL-37 and lipocalin 2 restricted growth of the organism, the latte

177 transcription, translation and secretion of lipocalin 2; secreted lipocalin 2 then limits bacterial

178 8 signaling is required for the induction of lipocalin 2 secretion and iron sequestration in the sple

179 ory factors such as dietary iron and luminal lipocalin 2 should be taken into consideration for optim

180 Lipocalin 2 (siderocalin, NGAL, 24p3), a siderophore-bin

181 s unique genes, such as guanosine deaminase, lipocalin 2, synaptotagmin 4, and latrophilin 2, whose t

182 wer circulating concentrations of HNP1-3 and lipocalin 2 than south Asian and white participants.

183 ation and secretion of lipocalin 2; secreted lipocalin 2 then limits bacterial growth by sequestratin

184 During RAAS activation, lipocalin 2 was related to biomarkers of inflammation (t

185 e frequency of neutrophils and the levels of lipocalin 2 were significantly increased in STAT1(-/-) m

186 ratory data with urinary and serum levels of lipocalin-2 were assessed.

187 vercome iron restriction by the host protein lipocalin 2, which counteracts some siderophores, is ess

188 his strategy is counteracted by host protein lipocalin-2, which sequesters iron-laden enterobactin.

189 ys identified numerous biomarkers, including lipocalin-2, which was then used to monitor the response