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2 ed from knees of rats with PTOA treated with liposomal A2AR agonist revealed downregulation of genes
7 accine Ag doses with a novel potent cationic liposomal adjuvant, cationic adjuvant formulation 09, co
8 iposomes, secondary binding may also lead to liposomal aggregation as detected by dynamic light-scatt
10 wn in both in vitro and in vivo studies that liposomal alendronate (L-ALD) can sensitise cancer cells
12 njected into the peritoneal cavity, free and liposomal alendronic acid were both highly effective as
13 , we investigated the efficacy and safety of liposomal amikacin for inhalation (LAI) in treatment-ref
16 reated with 30 mg/kg body weight intravenous liposomal amphotericin B (AmBisome) divided as 6 equal d
17 activity (EFA) of 3 short-course, high-dose liposomal amphotericin B (L-AmB) regimens for cryptococc
18 ty and efficacy of combination therapy using liposomal amphotericin B (LAmB) and MIL for treating PKD
19 ed safety profile and antifungal efficacy of liposomal amphotericin B (LAmB) compared to conventional
21 tolerability of high-dose weekly (10 mg/kg) liposomal amphotericin B (LamB) for antifungal prophylax
23 amined the pharmacokinetics of 1 and 2 mg/kg liposomal amphotericin B in 16 morbidly obese individual
29 phigus foliaceus died despite treatment with liposomal amphotericin B, 3 mg/kg/d, and a young girl wi
30 antifungal drugs, including amphotericin B, liposomal amphotericin B, and flucytosine, need to be mu
31 sed antimicrobials (meropenem, piperacillin, liposomal amphotericin B, caspofungin, and voriconazole)
32 center-specific standard care (fluconazole, liposomal amphotericin B, or caspofungin) posttransplant
33 hen prospectively screened twice a week, and liposomal amphotericin-B therapy initiated based on a po
34 B) for protein detection, which integrates a liposomal amplifier and sandwich immunoassay format with
36 ficacy in patients was not different between liposomal and conventional chemotherapy as assessed by o
41 findings have translational implications for liposomal approaches as well as for Apo2L/TRAIL and othe
43 investigated the immunomodulatory role of a liposomal AZM formulation (L-AZM) in a clinically releva
46 3004, a lipidated TLR7/8 agonist, within the liposomal bilayer in order to achieve co-delivery, allow
47 LR4 and lipidated TLR7/8 agonists within the liposomal bilayer leads to innate and adaptive immune sy
49 n this study, we describe the development of liposomal bortezomib nanoparticles, which was accomplish
50 -1-targeted multi-drug and even non-targeted liposomal BTZ formulations for the enhancement of patien
51 who received postprocedural intrapericardial liposomal bupivacaine (LB)+oral colchicine (LB group) an
52 gery compared with those who did not receive liposomal bupivacaine (mean [SD] age, 64.9 [8.4] years;
55 3, 2014-March 2, 2015) the implementation of liposomal bupivacaine for local infiltration in TKA.
56 [3.0-7.5]; P = .001), patients who received liposomal bupivacaine had greater median (interquartile
60 ractice: the effect of local infiltration of liposomal bupivacaine on perioperative outcomes in patie
63 e are no apparent clinical benefits to using liposomal bupivacaine transversus abdominis plane block
64 nesthesia care unit among those who received liposomal bupivacaine vs those who did not (4 vs 20; P =
65 it were improved among patients who received liposomal bupivacaine vs those who did not (4.0 [0.0-6.6
66 o pain was improved among those who received liposomal bupivacaine vs those who did not (44 vs 19; P
67 was also reduced among patients who received liposomal bupivacaine vs those who did not (49 vs 91; P
68 sured by morphine milligram equivalents when liposomal bupivacaine was compared to simple bupivacaine
69 cluded in the analysis, 57 patients received liposomal bupivacaine, 55 patients received simple bupiv
70 ormed transversus abdominis plane block with liposomal bupivacaine, simple bupivacaine, or normal sal
72 ultrasound is used as a stimulus to liberate liposomal calcium ions, which then trigger the enzymatic
74 tudy establishes the successful synthesis of liposomal carfilzomib nanoparticles that demonstrates im
78 nticity of the strong CD8(+) T-cell inducing liposomal cationic adjuvant formulation 09 (CAF09), whic
79 clude that simple analytical measurements of liposomal changes in lipid packaging, permeability, and
80 were synthesized to prepare transition metal liposomal chemical exchange saturation transfer (lipoCES
83 estigated the safety and efficacy of inhaled liposomal ciprofloxacin (ARD-3150) in two phase 3 trials
84 al schistosomiasis with macrophage-depleting liposomal clodronate (LC) to define how macrophages medi
87 ctomy or depletion of splenic macrophages by liposomal clodronate protects against PIFA-induced chemo
91 by depletion of monocytes or macrophages by liposomal clodronate treatment or genetic deficiency of
92 anced by pre-treatment of the recipient with liposomal clodronate, a macrophage depleting agent, with
102 rgeted therapies for mutant FLT3 and IDH2, a liposomal cytarabine-daunorubicin formulation for therap
104 inical trials directly comparing efficacy of liposomal cytotoxic chemotherapy versus their equivalent
105 e model and predict API suitability for nano-liposomal delivery by fixing the main experimental condi
107 s also rescued in a dose-dependent manner by liposomal delivery of a metabolically resistant methylen
108 oration of endothelial Foxm1 expression, via liposomal delivery of Foxm1 plasmid DNA to Hif1a(f/f)/Ti
112 his study, we designed a dual functionalized liposomal delivery system, surface modified with transfe
114 evaluated the influence of the EPR effect on liposomal distribution in vivo by injection of pegylated
115 us carboplatin (AUC 5, day 1) plus pegylated liposomal doxorubicin (30 mg/m(2), day 1) every 4 weeks,
116 igned a fibronectin-targeting CREKA-modified liposomal doxorubicin (CREKA-Lipo-Dox) for the therapy o
117 herapeutic outcomes than clinically approved liposomal doxorubicin (Doxil) in HER2-overexpressing BT4
119 itors, doxorubicin, etoposide, and pegylated liposomal doxorubicin (PLD) in vivo, utilizing ovarian c
122 amycin (mTOR) inhibition in combination with liposomal doxorubicin and bevacizumab in patients with a
125 s formulation than clinically representative liposomal doxorubicin for breast cancer treatment and pr
127 oxicity; however, it remains unclear whether liposomal doxorubicin is therapeutically superior to fre
128 eport rationally engineered peptide-targeted liposomal doxorubicin nanoparticles that have an enhance
129 vanced-stage KS, chemotherapy with pegylated liposomal doxorubicin or paclitaxel is the most common t
130 technique is able to identify both free and liposomal doxorubicin throughout the spheroid after just
132 acizumab, and temsirolimus (DAT) (N = 39) or liposomal doxorubicin, bevacizumab, and everolimus (DAE)
133 years; range, 37-79 years) were treated with liposomal doxorubicin, bevacizumab, and temsirolimus (DA
136 vestigators selected chemotherapy (pegylated liposomal doxorubicin, weekly paclitaxel, or topotecan),
137 ly assigned to receive carboplatin-pegylated liposomal doxorubicin-bevacizumab (experimental group) a
142 bility to both small dye molecules and large liposomal drug carriers were quantified using fluorescen
143 rstanding is required to optimize and design liposomal drug delivery systems capable of controllable
148 AF4) to accurately and reproducibly separate liposomal drug formulations into their component populat
149 nique may prove useful for rapid analysis of liposomal drug formulations or rapid, robust, direct mea
150 y, by supplementing ablation with concurrent liposomal drug therapy, a complete and durable response
151 rably over the past few decades, and several liposomal drugs are already providing improved clinical
152 inical and commercial success of a number of liposomal drugs, each of which required a tailored formu
154 atechin or free green tea extract (GTE), and liposomal encapsulated catechin or liposomal encapsulate
156 ection model was used to investigate whether liposomal-encapsulated prednisolone (LP) facilitates loc
160 lexes with the explicit aim of demonstrating liposomal encapsulation, bioavailability in cultured neu
161 apsulation method to nucleobase analogues, a liposomal entrapment method once conceived useful only f
162 Cl(-) flux process with the use of different liposomal fluorescence assays, and supported by addition
166 Among them, compound 29d encapsulated in a liposomal formulation (e.g., 29dL) significantly suppres
167 at the passive delivery of an edge-activated liposomal formulation can effectively carry siRNA throug
172 sdegib to target the hedgehog pathway, and a liposomal formulation of daunorubicin and cytarabine (CP
174 in, we report a novel radioprotector drug, a liposomal formulation of gamma-tocotrienol (GT3), or GT3
175 e verified experimentally and PEGylated nano-liposomal formulation of mupirocin (Nano-mupirocin) was
177 of these specific macrophages, we designed a liposomal formulation of vancomycin that is efficiently
179 on recent advances in peptide-functionalized liposomal formulation techniques in cancer diagnosis and
180 so will highlight different aspects of novel liposomal formulation techniques that incorporate surfac
182 the circulation after the administration of liposomal formulation was characterized by prolonged cir
187 other linkers to achieve surface adsorption, liposomal formulation, and encapsulating nanoparticles a
190 to monitor TPT release from actively loaded liposomal formulations having a low intravesicular pH.
191 ns, with the largest class of products being liposomal formulations intended for cancer treatments.
194 ty and performance seen with actively-loaded liposomal formulations of TPT and other weakly-basic ant
196 Present achievements in: (i) preparation of liposomal formulations of VE analogues, (ii) physico-che
201 enicity in both free (micellar) state and in liposomal formulations when tested in rabbits in vivo (s
202 ty and physicochemical properties typical of liposomal formulations, preferentially targeted inflamed
204 ling during UF; and (3) preozonation reduces liposomal fouling during UF, likely due to the disruptio
207 nced MRI using a long circulating blood-pool liposomal gadolinium contrast agent that does not penetr
208 ectably low transplacental permeation of the liposomal Gd agent, while the clinical agent (Multihance
211 creased tumor uptake of both gemcitabine and liposomal gemcitabine and significantly improved anti-tu
212 ive tumor model of murine pancreatic cancer, liposomal gemcitabine combined with local hyperthermia i
217 ed membrane permeabilization is enabled with liposomal inclusion of 10 molar % porphyrin-phospholipid
218 able, focusing on this new generation of non-liposomal L-NVs and showing their similarities and diffe
219 field of L-NV design and synthesis, and non-liposomal L-NVs have been recently developed; this new g
220 old nanoparticles that are encapsulated in a liposomal (Lip) system that can produce H2 gas in situ u
221 are taken up, their CE core is hydrolyzed by liposomal lipases to generate free cholesterol (FC).
225 dies, we describe ADx-001, an Abeta-targeted liposomal macrocyclic gadolinium (Gd) imaging agent, for
227 duced by mechanically induced defects in the liposomal membrane caused by the oscillation of the iron
228 ed that over 90% of tPA was released through liposomal membrane destabilization involving membrane fu
229 uncontrolled passive permeability across the liposomal membrane or upon fusion with other membranes.
230 cell-penetrating peptide-modified fusogenic liposomal membrane was coated on the core, which had an
231 However, when the phospholipids within the liposomal membrane were hydrolyzed by PLA2, encapsulated
234 de anion and sodium cation transport in both liposomal models and cells, and promote cell death by in
235 enhance the transport of chloride anions in liposomal models and promote sodium chloride influx into
238 ely and support the rapid translation of new liposomal nanomedicines from bench to bedside, new cost-
239 understanding and optimizing the effects of liposomal nanoparticle design parameters for enhancement
241 , recent reports show that certain pegylated liposomal nanoparticles (PLNs) and polymeric nanoparticl
244 combination with a near-infrared dye, these liposomal nanoparticles can serve as bimodal PET/optical
246 rategy to target Siglecs involves the use of liposomal nanoparticles with a multivalent display of Si
250 ical utilization feasibility of niosomal and liposomal nanovesicles loading Isoleucine-Proline-Prolin
253 Rs or MHC class II molecules on B cells, the liposomal particles also elicited IgM, IgG1, IgG2b, and
254 emained limited due to the slow diffusion of liposomal particles within the tumor and limited release
255 his process, we have synthesized a series of liposomal particles, similar to the size of viruses, tha
256 , (ii) development of PEGylated and targeted liposomal PAs, (iii) physico-chemical characterization o
258 C-3 cell line, and binding was observed with liposomal peptide concentrations as low as 0.16mol%.
262 ared to spray dried extract, chitosan coated liposomal powders provided better protection of anthocya
263 AAML1421 is a phase I/II study of CPX-351, a liposomal preparation of daunorubicin and cytarabine.
266 dose of 50 mg taxane/kg, ephrin A2-targeted liposomal prodrug showed greater antitumor activity than
268 nged the biodistribution compared to the non-liposomal radiopeptide in vivo, although interestingly t
269 fluorescence method was developed to monitor liposomal release kinetics of the anticancer agent topot
270 ese findings, the developed model describing liposomal release of TPT may be used in the future to ev
273 or far weaker in intensity in the spectra of liposomal sample containing ciprofloxacin nanocrystals.
275 nt study, an electrochemical method based on liposomal signal amplification platform is proposed for
276 t inhibition of angiopoietin-2 expression by liposomal siRNA in vivo improved absolute survival by 50
277 ynthesis and evaluation of immunotherapeutic liposomal spherical nucleic acids (SNAs) for TNBC therap
278 prised of spherically-arrayed antisense DNA (liposomal spherical nucleic acids [L-SNAs]), which are a
282 erest for stabilization/functionalization of liposomal surfaces as well as detection of polyvalent mo
283 replacement by intra-articular injection of liposomal suspensions containing adenosine prevents deve
284 ostasis and here we report that injection of liposomal suspensions of either adenosine or a selective
288 ed to investigate the antifungal activity of liposomal systems containing Spirulina sp. LEB-18 phenol
290 d optimize loading and subsequent release of liposomal TPT formulations utilizing active loading stra
296 l administration of vancomycin (particularly liposomal vancomycin with optimized intracellular penetr
299 for detailed analysis of fusion kinetics for liposomal, viral, and cellular fusion processes; however
300 been suggested as a suitable alternative to liposomal ZOL (L-ZOL), due to unexpected mice death expe