ライフサイエンスコーパス: littermate

1 PKARIalpha knock-in mice and their wild-type littermates.

2 both males and females compared with control littermates.

3 ogical severity than their wild-type control littermates.

4 ainst fibrosis, compared with wild-type (WT) littermates.

5 abolic dysfunction relative to nontransgenic littermates.

6 d in Grhl2 KO mice compared to the wild-type littermates.

7 ith their AAV2/9-GFP-injected or noninjected littermates.

8 al striatum of Sapap3-KOs and wild-type (WT) littermates.

9 ct rapidly diminished following reunion with littermates.

10 cortex of synGLT-1 KO compared with control littermates.

11 strikingly different from that of their E3wt littermates.

12 day 9 (P9) in cortex, compared to wild-type littermates.

13 b11 levels in the Nhe6 KO OC, compared to WT littermates.

14 r female (n = 19) and male (n = 17) Cbs(+/-) littermates.

15 ments in cognitive tasks compared with 5xFAD littermates.

16 ived from either Zbtb32(-/-) mice or control littermates.

17 erular filtration rate compared with control littermates.

18 tly shorter in vivo than those of Cd40 (+/+) littermates.

19 ry thresholds between DKO mice and wild-type littermates.

20 ice lacking MuRF1 (MuRF1(-/-)) and wild-type littermates.

21 knockout (KO) mice, and their wildtype (WT) littermates.

22 inflammatory response compared with APP/PS1 littermates.

23 ed Tet1-deficient mice compared to Tet1(+/+) littermates.

24 dysbiosis was milder in 619W mice than in WT littermates.

25 lymorphic mice compared to that of wild-type littermates.

26 PMP22_L16P) mice had larger currents than WT littermates.

27 in the basolateral amygdala compared with WT littermates.

28 h as compared with Ptch1(+/+)/ODC(t)/C57BL/6 littermates.

29 agic phenotype when compared with ERalpha KO littermates.

30 eased impulsivity relative to wild-type (WT) littermates.

31 nd in patients, were compared with wild-type littermates.

32 similar between Zbtb32(-/-) mice and control littermates.

33 gnificant differences compared with their WT littermates.

34 rated carcinogenesis compared with wild-type littermates.

35 e otherwise indistinguishable from wild-type littermates.

36 were 20% and 50% lower compared to wild-type littermates.

37 re compared with those of the wild-type (WT) littermates.

38 ive stress compared to aortas from wild type littermates.

39 le and female KO mice as compared to control littermates.

40 ly indistinguishable from those of wild-type littermates.

41 ivation of ventral CA1 relative to wild-type littermates.

42 nced in transgenics and induced in wild-type littermates.

43 ice was indistinguishable from wildtype (WT) littermates.

44 ce compared with their wild-type (Npr2(+/+)) littermates.

45 eys, compared with Klotho(+/-) and wild-type littermates.

46 ADM (adrenomedullin) compared with Bmp9(+/+) littermates.

47 infections more slowly than their wild-type littermates.

48 ured, and cells were injected into wild-type littermates.

49 abolome when compared to their respective WT littermates.

50 abnormalities compared with their HPIP(f/f) littermates.

51 al vascular tuft formation than did their WT littermates.

52 of fast and slow muscles from wild-type (WT) littermates.

53 thy at age 20 weeks compared with their db/m littermates.

54 knock-out mice but preserved in heterozygous littermates.

55 ce memory compared with APP/PS1 aged-matched littermates.

56 ared with macrophages from placebo-implanted littermates.

57 cing of ATXN2Q127 mice versus wild-type (WT) littermates.

58 operoxidase activity compared with wild-type littermates.

59 p3L351P Casp1/11-/- mice and Il1b-/- Il18-/- littermates.

60 ke (DNM1L) protein-knockout mice or their WT littermates.

61 red with age-matched hyperglycemic ApoE(-/-) littermates.

62 halamus compared with that seen in wild-type littermates.

63 lls (RGCs) of Tg-TBK1 mice than in wild-type littermates.

64 ba(-/-) embryos in comparison with wild-type littermates.

65 ce, global HCN1 knockouts and their wildtype littermates.

66 sduced with the EHITSN relative to wild-type littermates.

67 -old Hri(-/-) mice as compared with Hri(+/+) littermates.

68 (-/-) mice were smaller than their wild-type littermates.

69 ild-type (Cdc73(+/+) and Cdc73(+/+)/PTH-Cre) littermates.

70 mia, and nephropathy that are present in ZDF littermates.

71 nza viruses of human origin as nontransgenic littermates.

72 eir activity and sleep compared to wild-type littermates.

73 hen compared to the nonmutant il17a knockout littermates.

74 -deficent embryos in comparison with control littermates.

75 that was not different from that in control littermates.

76 ormal and cone ERG(absent) RPGRIP1 (ins/ins) littermates.

77 toperiod exposure versus their wildtype (WT) littermates.

78 showed similar weight gain as the wild-type littermates.

79 h, and loss of beta-cell mass observed in Ak littermates.

80 els compared with Nf1(flox/flox);PostnCre(-) littermates.

81 of ligature-induced PD on 5xFAD mice and WT littermates.

82 patocyte-specific p53 wild-type and knockout littermates.

83 es within the neural tissue compared with WT littermates.

84 schemia injury compared with their wild-type littermates.

85 ordings, compared with age-matched wild-type littermates.

86 ed in homozygous del10 mice compared with WT littermates.

87 ine transporter knockdown mice and wild-type littermates.

88 rature control compared with their wild-type littermates.

89 owed significant hearing loss compared to WT littermates.

90 h1(fl/fl)/Podo(Cre) mice compared with their littermates.

91 TH were observed, when compared to wild-type littermates.

92 e lung compared with SPC-Cre(-) RSV-infected littermates.

93 ed in the SG of Nhe6 KO mice, compared to WT littermates.

94 knockout mice compared with control genotype littermates.

95 stimulation compared with their Ucp2(fl/fl) littermates.

96 function and had no effect on wild-type (WT) littermates.

97 (+/-) ) mice when compared with nondiabetic littermates.

98 d pH and a decrease in pCO(2) compared to WT littermates.

99 No LacZ staining was detected in wild-type littermates.

100 and compared with those in healthy wild type littermates.

101 days in wild type to only 568 days in S180A littermates.

102 rom colitis than Arg1-expressing (Arg1fl/fl) littermates.

103 ls compared with Nf1(flox/flox);PostnCre (-) littermates.

104 TNF and IL-6 compared with their Sema3e(+/+) littermates.

105 mg kg(-1) per infusion) than their wild-type littermates.

106 nificantly different from those of wild type littermates.

107 ality (P = 0.02) compared with wildtype (WT) littermates.

108 fatty liver disease compared with wild type littermates.

109 sgenic (SIRT2-Tg) mice, and their respective littermates (8 to approximately 12 weeks old).

110 Compared to their wild-type littermates, administration of THC to male and female FA

111 and glucose tolerance compared with control littermates after 10 weeks of a high-fat diet in male mi

112 sed mortality in contrast with the wild-type littermates after polymicrobial sepsis or endotoxemia ch

113 h 8 wk poststroke compared to wild type (WT) littermates also receiving rituximab.

114 d old TAU58/2 mice relative to nontransgenic littermates and by comparative analysis with a dataset o

115 e, had lower body weight than wild-type (wt) littermates and gray fur.

116 produce interleukin-12 than their wild-type littermates and lower levels of interferon-gamma mRNA we

117 unction and cell type composition of control littermates and mice with conditional Notch signaling in

118 onist and cocaine cross-sensitize in control littermates and this effect was potentiated in mice lack

119 serum calcium concentrations than wild-type littermates, and Cdc73(+/-) mice also had increased mean

120 BK/BK mice live longer than WT littermates, and have heightened phosphaturia from downr

121 rable to maternal ARI exposure than their WT littermates, and maternal Dhcr7(+/)(-) genotype also exa

122 omozygous CNP-hEGFR mice versus heterozygous littermates, and neurofibroma number and size increased

123 The cells were injected into wild-type littermates, and orthotopic tumor growth and metastasis

124 a constitutively active form of TLR4, their littermates, and villin-TLR4 mice backcrossed to DUOXA-k

125 as compared with age-matched non-transgenic littermates, and western blots showed increased lysosoma

126 reased intestinal tumor burden compared with littermate Apc (Min/+) mice.

127 er compared with that of control Tfrc(fl/fl) littermates as a result of the reduced capacity of Tfr1-

128 detected between Tg-TBK1 mice and wild-type littermates as they aged (P > 0.05).

129 otype in KO rats compared to their wild-type littermates as well as a dose-dependent phenotype attenu

130 hondria from YAC128 mice and their wild-type littermates as well as in mitochondria from postmortem b

131 orta and coronary arteries compared to their littermates (Asah1(fl/fl)/SM(wt) and WT/WT mice) after r

132 dy and bone length compared to their control littermates at 16 weeks of age.

133 were indistinguishable from their wild-type littermates at birth, but they rapidly worsened and died

134 macrophages compared with their Sema3e(+/+) littermates at both baselines and after LPS challenge.

135 from the zQ175 HD mouse model and wild type littermates at two months of age.

136 ollected from pups at week 5 (W5), and their littermates at week 39 (W39).

137 Compared with wild-type littermates, BACE1(-/-) mice of either sex exhibit signi

138 Compared with control littermates, beta-cat cKO mice display severe cognitive

139 Relative to control littermates, beta-cat cKOs exhibit reduced levels of key

140 deprivation-induced atrophy compared with WT littermates by preserving a higher protein synthesis rat

141 ed thicker skin in comparison with wild-type littermates consistent with a hyperproliferative epiderm

142 gained less body weight compared to wildtype littermate control (M-JAK2(+/+)) mice and were protected

143 FAD mice could be distinguished from littermate control animals with a sensitivity of 85.7% a

144 more vulnerable to infection than wild-type littermate control animals.

145 4W mice compared with that in wild-type (WT) littermate control animals.

146 eural tubes isolated from E9.0 EpoR-null and littermate control embryos validated our in vitro findin

147 resolved completely between days 8 and 9 in littermate control mice (n=12), but were still present a

148 EPOR) signaling (hWtEPOR) were compared with littermate control mice (WT) to test the role of EPOR si

149 PON1 knock-out mice [PON1KO], and wild type littermate control mice [WT].

150 We found evidence that littermate control mice develop D1R hypersensitivity aft

151 in Cpt2M(-/-) hearts 2.3-fold compared with littermate control mice fed a ketogenic diet, yet it did

152 eceptor rescue compared with vehicle-treated littermate control mice.

153 young adult B cell-specific Traf3 (-/-) and littermate control mice.

154 er, studies to date have utilized either non-littermate control rat models, or mouse models that lack

155 athogen herpes simplex virus-1 compared with littermate control RIPK3-deficient or WT C57BL/6 mice, s

156 e head-fixed mice (Setd1a(+/-) vs. wild-type littermate control) during rest and visual stimulation w

157 SCD and their littermates control mice were treated with antibiotics t

158 tiple inflammasome-deficient mice, including littermate-controlled Nlrp6(-/-) , detect a functional I

159 eletion of leptin receptors (End.LepR-KO) or littermate controls (End.LepR-WT).

160 ha on B cells (mb1(cre)IL-4Ralpha(-/lox)) or littermate controls (IL-4Ralpha(-/lox)) and mice lacking

161 genic rabbit models of LQT2, LQT1, and their littermate controls (LMC) using random stimulation proto

162 ain slices from Scn1a(+/-)mice and wild-type littermate controls and found prominent impairment of ir

163 ter adrenergic stimulation in wild-type (WT) littermate controls and R67Q(+/-) mice.

164 red cocaine self-administration similarly to littermate controls and showed no significant change in

165 g the MN translatome of hTDP-43A315T mice to littermate controls and to mice expressing wild type hTD

166 at mass when on high-fat diets compared with littermate controls and were prevented from hepatosteato

167 STIM1(flox/flox)-Cre(tg)(/-) (STIM1-KD) and littermate controls for STIM1(flox/flox) (referred to as

168 r SCI, and highlight the importance of using littermate controls in studies involving genetic manipul

169 We exposed 5XFAD mice and littermate controls to dim-light vs. bright-light photop

170 d Npr2(+/)(-);Ldlr(-/)(-) mice and wild-type littermate controls to examine the valvular effects of d

171 gnaling (SIRP-alpha(mut)) and wild-type (WT) littermate controls underwent renal ischemia and reperfu

172 out (EC-miR-15a/16-1 cKO) mice and wild-type littermate controls were subjected to 1 hour middle cere

173 evant to OCD, Sapap3 knockout mice (KOs) and littermate controls were tested in an instrumental rever

174 susceptible to tumor growth than were their littermate controls when challenged with the established

175 se progression to twice the rate observed in littermate controls with intact PHP.

176 icantly attenuated scratching, compared with littermate controls, after AD-like disease induction.

177 n of hyperglycemia compared to hyperglycemic littermate controls, although this dysfunction was not a

178 gastrointestinal motility in these mice and littermate controls, and analyzed epithelial cell prolif

179 Compared with littermate controls, cKO mice fed an HFD (16 weeks) had

180 SMA embryos were significantly smaller than littermate controls, indicative of general developmental

181 c evaluation, we have shown that compared to littermate controls, the NF1 model develops phenotypic c

182 ut (Gcgr(-/-)) mice and their wild-type (WT) littermate controls, we examined the response of inguina

183 eloid cells) had significantly lower BP than littermate controls, whereas basal BP was unaltered in C

184 Unlike the corneal epithelium of the littermate controls, which consisted of 5-6 cell layers

185 of senescence and inflammation compared with littermate controls, while plaques of SM22alpha-hSIRT6(H

186 re more glucose tolerant than wild type (WT) littermate controls.

187 ale and female three-month 5xFAD mice versus littermate controls.

188 lipoprotein (VLDL) levels, as compared with littermate controls.

189 the Dox-induced mutant mice, compared to the littermate controls.

190 onditioned place preference compared with WT littermate controls.

191 (nu/+) mice and age-matched wild-type (+/+) littermate controls.

192 ic mice expressing human CysC as compared to littermate controls.

193 se of intense seizures, which was evident in littermate controls.

194 cantly reduced in Bcl-2(PC) mice compared to littermate controls.

195 reased incidence of severe NEC compared with littermate controls.

196 nificantly increased in the mutant mice over littermate controls.

197 neonatally-incised mice compared with naive littermate controls.

198 re also observed in both NaV 1.7(Nav1.8) and littermate controls.

199 nd compared SGNs in Pou3f4 knockout mice and littermate controls.

200 cal tricuspid aortic valves or all wild-type littermate controls.

201 mice cochleae compared with their wild-type littermate controls.

202 and body weight acquisition compared to the littermate controls.

203 abnormal age-related involution compared to littermate controls.

204 r but not the axial skeleton compared to the littermate controls.

205 ose tissue and skeletal muscle compared with littermate controls.

206 rd-/+), as compared to their female wildtype littermate controls.

207 sponse to sensory input, compared with naive littermate controls.

208 compared with single knockout (KO) mice and littermate controls.

209 hepatic inflammation when compared to their littermate controls.

210 ipose tissue thermogenic capacity than their littermate controls.

211 terozygous colony to generate C6 WT and C6-D littermate controls.

212 y, from Nr1d1(-/-) mice and their Nr1d1(+/+) littermates (controls) and analyzed expression NLRP3, in

213 In comparison with wild-type littermates, Ddr2(slie/slie) mice displayed disproportio

214 Littermate-derived WT and ICF1 MEFs demonstrated no sign

215 lasia in prostates, whereas age-matched Pten littermates developed high-grade prostatic intraepitheli

216 Non-diabetic littermates, diabetic Akita mice +/- insulin implant, Ak

217 of socialised piglets to play fight with non-littermates did not affect subsequent lesions.

218 ompared with WT mice, cyclophilin D-knockout littermates did not develop bioenergetic stress in respo

219 control level, Podo-GC-A KO mice and control littermates did not differ in BP, GFR, or natriuresis un

220 dominance plasticity between NF1 mice and WT littermates disappear.

221 VL3-ablated (E3hom) mice and their wild type littermates (E3wt) were studied side by side.

222 y exposed to prenatal testosterone from male littermates exhibit altered physical and behavioral trai

223 re examined and compared with wild-type (WT) littermates following intranasal exposure to HDM allerge

224 Here we show that, in contrast to their lean littermates, genetically obese (ob/ob) mice have a defec

225 -housing, antibiotic treatment or colonizing littermate germ-free wild-type and NLRP6-deficient hosts

226 aIEC)); we compared phenotypes with those of littermate H2b(fl/fl) or H2b/p53(fl/fl) (control) mice a

227 -knockout mice (znt7-KO) and their wild type littermates in a mixed 129P1/ReJ (129P1) and C57BL/6J (B

228 oped fewer and smaller tumors than wild-type littermates in a model of inflammation-driven colon tumo

229 OIM(-/-) mice are smaller than their WT littermates in body mass, craniomandibular CS, and absol

230 We then tested DAT-HT mice and WT littermates in psychiatry-relevant behavioral tests afte

231 hium responsivity relative to wild-type (WT) littermates in tail suspension, an antidepressant-predic

232 vioral arousal than their heterozygous (Het) littermates in the open field test.

233 We used CTSC-deleted mice and their WT littermates in two experimental models of pancreatitis.

234 striction for 2 weeks, compared with control littermates, inducible renal tubular NEDD4-2 knockout (N

235 it-diaphragm density compared with wild-type littermates injured by either protamine sulfate or nephr

236 stinal inflammation, while transfers from WT littermates into Arg1-deficient mice prevented an advanc

237 Compared with wild-type littermates, Kmt2d(+/betaGeo) mice demonstrated deficien

238 Compared with control littermates, knockout mice showed impaired glucose toler

239 Relative to wild-type littermates, knockout mice showed no gross pathologies.

240 trophils (LysMCre;Mcl1(fl/fl)) and wild-type littermates (LysMCre;Mcl1(wt/wt), control mice) by admin

241 n VOCs between Cushing's mice/wild-type (WT) littermates, mainly short-chain fatty acids (SCFAs), ket

242 Unlike their MIP-TF littermates, MHV68-EGFP-infected A(vy)/MIP-TF mice devel

243 knockouts (APNko), and their wild-type (WT) littermate mice were continuously exposed to placebo or

244 kinase mutant (KHK)(-/-)] and wild-type (WT) littermate mice were used and received a 20%-fructose (K

245 nitiated in 3 weeks old randomized Sh3tc2-/- littermate mice which received either the full or mock (

246 In littermate mice with severe inflammation, both CD4(+)Fox

247 Rag1(-/-) STING N153S mice than in Rag1(-/-) littermate mice, which completely lack adaptive immunity

248 B(hi) to FcgammaR(-/-)Rag1(-/-) or Rag1(-/-) littermates; mice were given different antibodies agains

249 cystic kidney disease (Cy/+ (IU)) and normal littermates (NL) were given access to a voluntary runnin

250 ntrol astrocytes isolated from nontransgenic littermates (NTg).

251 only half the extra REM sleep wild-type (WT) littermates obtained during recovery.

252 This study used littermates of WT and Nox2-knockout (Nox2KO) mice plus e

253 at diet they gain less weight than wild type littermates owing to reduced food intake.

254 than that in parathyroid glands of wild-type littermates (P<0.0001).

255 ion of PMCA1 (PMCA1(cko) ) and their control littermates (PMCA1(loxP/loxP) ) were studied at the orga

256 muscle atrophy compared with wild-type (WT) littermates presumably by the increased proteolysis.

257 pinal cord injury and recovery, we generated littermate PVG C6 wildtype and deficient rats and tested

258 lar epithelial damage compared with their wt littermates (RSK-wt), indicating a role of p90RSK in fib

259 Unoperated littermates served as controls.

260 he airway of Dp16 mice compared to wild-type littermates, showing the potential risk of upper airway

261 Smad1/5/8 triple (Smad158;Alb-Cre(+) ), and littermate Smad1/5 double (Smad15;Alb-Cre(+) ) knockout

262 rom ~ 15 days of age and interacted with non-littermates (socialised).

263 ceral hypersensitivity compared with control littermate Sox9(flox/flox) mice.

264 sed perineuronal nets in the brains of naive littermates, suggesting a new role for microglia as home

265 dopamine transients is observed with age in littermates, suggesting premature ageing of dopamine syn

266 rom CD83(flox/flox)/CD4-cre(wt/wt) wild-type littermates, suggesting that endogenous CD83 expression

267 r formation and invasion compared with their littermates that expressed only stabilized beta-catenin.

268 Compared with Cre-negative littermates, the refraction and axial dimensions of Chx1

269 manifestations in D1CT-7, but not wild-type littermates; these effects were countered by the benchma

270 (EC-AGO1-knockout [KO]) and their wild-type littermates to a fast food-mimicking, high-fat high-sucr

271 the Ts65Dn mouse relative to normal disomic littermates, to examine the effects on gene expression w

272 n = 7) mice or their wild-type (WT, n = 10) littermates under exercise or sedentary conditions were

273 hrelin knockout (KO) mice and wild-type (WT) littermates underwent an insulin bolus-induced hypoglyce

274 9 deficient (pcsk9 (-/-)) and wild-type (WT) littermates underwent partial inferior vena cava (IVC) l

275 generation, compared with platelets from WT littermates, upon stimulation with both G protein-couple

276 omozygous (Scn8a(D/D))), and WT (Scn8a(+/+)) littermates were compared at 3 weeks of age, the time of

277 delta knockout (delta-KO) and wild-type (WT) littermates were exposed to aortocaval shunt-induced VO,

278 WT), Mmp20-null (KO), and heterozygous (HET) littermates were prepared.

279 overexpressing human BMF in RPTCs and non-Tg littermates were studied at 10 to 20 weeks of age.

280 Ppp1r3a-knockout mice and wild-type littermates were subjected to in vivo programmed electri

281 ic mice (hCOX-2-Tg) and their wild-type (Wt) littermates were subjected to IRI.

282 TgCRND8 AD mice and their wild-type littermates were treated for 1 year with dabigatran etex

283 Vehicle-treated littermates were used as wild type controls (WT).

284 us proliferation compared with unmanipulated littermates, whereas crypt proliferation was decreased.

285 fasting glucagon levels than their wild-type littermates, whereas insulin and GLP-1 levels remained s

286 pression of Slc34a2 and Trpv5 than wild-type littermates, which suggests a regulatory role for testic

287 ls and more hemorrhages than their wild-type littermates, which was suggestive of a vascular abnormal

288 321Gly homozygote mice compared to wild-type littermates, while the staining of cerebellar Purkinje c

289 hier and longer life-span when compared with littermate wild type mice.

290 Rgamma deletion (PPARgamma((-/-))) and their littermate wild-type (PPARgamma((+/+))) controls.

291 mice that overexpress human A53T protein and littermate wild-type mice received a single injection of

292 kout (mdKO) mice and AMPKalpha1alpha2lox/lox littermates (wild-type [WT]).

293 -like transgenic (Tg) mice and wildtype (WT) littermates with a single, whole-body dose of 10 or 50 c

294 in tropomyosin (Tm-E180G) and nontransgenic littermates with FTY720 or vehicle for 6 weeks.

295 ll mutation in the Sharpin gene and their wt littermates with or without B16-F10-luc melanoma tumors

296 asally infected Scnn1b-Tg mice and wild-type littermates with the laboratory P. aeruginosa strain PAO

297 n male mice, compared with their age-matched littermate WT controls, Keap1 Ht mice showed significant

298 face in Notch2(tm1.1Ecan) mice compared with littermate WT controls.

299 ography was comparable to adult (8-week-old) littermate WT mice, hWtEPOR mice had thinner inner and o

300 mate) K(mf) were higher (P0 versus wild-type littermates, WTL) at E15.5.