ライフサイエンスコーパス: little or no

1 rison of lens cortex versus nucleus revealed little or no (15)N-protein contents in most nuclear prot

2 the clinical benefit of PDT to regions with little or no access to electricity or medical infrastruc

3 replication-competent provirus, but exhibit little or no active viral gene expression and effectivel

4 greater efficacy for endocarditis, and also little or no activity against those bacteria that remain

5 lar sized pore-formers at pH 5, while having little or no activity at pH 7, as intended.

6 rom loaded microsomes, whereas BPA exhibited little or no activity at these targets.

7 found to be highly selective for Mnk2, with little or no activity for Mnk1.

8 oxylate-terminated CDs (CD-CO2(-)) displayed little or no activity, and the electrostatic interaction

9 sence of aqueous buffer, most enzymes retain little or no activity; however, "water-free" enzymes wou

10 However, autistic observers showed little or no adaptation, although their simultaneity cur

11 nd aligning magneto-optical traps, requiring little or no additional equipment or setup beyond what i

12 esolution versus recovery balance as well as little or no analyte loss, respectively.

13 Interestingly, the compounds have little or no antiviral activity on the replication of ot

14 t for biochars produced from pure compounds (little or no ash), acid-washed biomass (little ash), and

15 There is little or no association between tea consumption and end

16 ironment in utero and in early childhood had little or no association with asthma but was associated

17 ion in natural backgrounds that has received little or no attention in the masking literature, which

18 Little or no attention is placed on the environmental im

19 porate as much information as possible, with little or no attention paid to the issue of statistical

20 s, whereas the vast majority of them receive little or no attention.

21 thways involving multiple spin states having little or no barrier.

22 g antibody specificity in other formats have little or no bearing on specificity within a ChIP experi

23 prevention of cardiovascular disease showed little or no benefit and have even suggested net harm.

24 87]) but not nonfatal stroke; aspirin showed little or no benefit for all-cause or cardiovascular mor

25 linically diagnosed subjects with AD confers little or no benefits over time.

26 inducing short endocytic dwell times produce little or no beta-arrestin signalling, whereas those eli

27 onal logistic models indicates that there is little or no bias from uncontrolled time-constant reside

28 ired for ERK-IQGAP1 binding, and contributes little or no binding energy to this interaction, challen

29 ver the course of the experiment, indicating little or no bioaccumulation.

30 Very little or no Bmx mRNA was expressed in human cardiomyocy

31 l fibre-Purkinje cell glutamatergic synapse, little or no Ca(2+) entry takes place through postsynapt

32 of La(3+), coordinated Ca(2+) but exhibited little or no catalytic activity.

33 fection by these viruses to cells expressing little or no CD4 in vivo.

34 aching end-stage renal disease or dying with little or no chances of kidney transplant (KTx) due to t

35 of one-carbon metabolic processes exhibited little or no change after supplementation in low-vitamin

36 Fundus autofluorescence showed little or no change except in severe cases in which the

37 unable to produce the ORF113 protein showed little or no change in its growth rate in vitro, in its

38 or gamma subunit knuckle domain resulted in little or no change in Na(+) self-inhibition.

39 ast coverage expansions were associated with little or no change in society-wide hospital use; increa

40 also suggests that promoter escape involves little or no change in the interaction of sigmaR2 with R

41 erior TPS with elevation larger than 4000 m, little or no change over the southeastern TPS, and incre

42 orophyll forms within 0.1-20 ps and revealed little or no charge separation and oxidation of the spec

43 s, and a large number of other viruses, with little or no clinical signs of disease.

44 tients), which assessed self-monitoring with little or no co-intervention.

45 We searched for but found little or no comparative effectiveness evidence about st

46 f one template to the 3' end of another with little or no complementarity between the donor and accep

47 ed primarily on minimizing Type I error with little or no concern about concomitant increases in Type

48 t underlie homologous characters occurs with little or no concomitant change in the adult phenotype.

49 ical shifts arise from states where there is little or no conformational bias.

50 ssment in non-human primates, there has been little or no consensus as what should be assessed.

51 t XTRPM6 regulates radial intercalation with little or no contribution from XTRPM7 in the region late

52 at RS in IT has a transsynaptic origin, with little or no contribution of intrinsic firing rate fatig

53 sensitive cones (S-cones) in the retina make little or no contribution to luminance signals, leading

54 e of robust cardiomyogenesis and others with little or no contribution to myocytes).

55 uced clinical advances, it has thus far made little or no contribution to our understanding of popula

56 ing initially overdense flat interfaces with little or no control over the interaction.

57 xation of C60 molecules, albeit usually with little or no control over their long-range order.

58 mal use of medications often executable with little or no cost to the patient.

59 Due to little or no cross sensitivity to other ions (e.g., Mg(2

60 s for r15 had 290-fold resistance to Cry1Ac, little or no cross-resistance to Cry2Ab, and completed i

61 t are typical of mantle that has experienced little or no crustal interaction.

62 These species have little or no cytotoxic activity in several bioassays.

63 dormancy of Mycobacterium tuberculosis, with little or no cytotoxicity toward mammalian cells.

64 ations at low micromolar concentration, with little or no cytotoxicity.

65 ly in Europe, the USA, Japan, and China, but little or no data are available from the Middle East, So

66 Although a crucial endpoint, little or no data exists in the public domain.

67 nty surrounding estimates for countries with little or no data is large; and (ii) although some adjus

68 onstrate that fMRI-based motion decoding has little or no dependence on the underlying functional org

69 n for frequencies over 200 Hz, the AP showed little or no depression.

70 gap junction plaques or, if they do, produce little or no detectable junctional coupling.

71 These mice had little or no detectable viral replication, comparable to

72 Little or no dhurrin or recycling products were present

73 food varied among the source materials, but little or no difference was observed among the soil type

74 he same type of charge as the surface showed little or no difference, except that the signal inverted

75 , PFOS: 0.28-2.1 ng g(-1) wet-weight), with little or no differences when comparing 2013 or 2014 fis

76 et of the vinblastine analogues that display little or no differential in activity against a matched

77 m, causing disease of variable severity with little or no direct systemic effects.

78 graphic hypotheses, the femur was subject to little or no directional selection despite having shorte

79 iverse major groove ICLs that induce severe, little or no distortion in the DNA.

80 idemiology, yet many epidemiologists receive little or no education in the conceptual underpinnings o

81 -sotalol, thioridazine, and erythromycin) to little or no effect (haloperidol, moxifloxacin, and vera

82 rate biomass in the mesocosms, but there was little or no effect of the phenotype.

83 Five mutations with little or no effect on ABCB4 expression at the bile cana

84 ng-closing ester bond with an amide bond had little or no effect on activity.

85 uggest that TRPC5 ion channel permeation has little or no effect on atherosclerosis or steatosis but

86 Deviation from the CentC consensus has little or no effect on binding of cenH3.

87 versely, mutations N97S, D95V, and D129G had little or no effect on Ca(2+) binding to the N-domain bu

88 permissive temperatures, mutant Pop1/6 have little or no effect on cell growth, global protein level

89 ti-platelet agents and statins) seem to have little or no effect on CKD-associated MCI, suggesting th

90 noid ligands tested, at the same time having little or no effect on ERK1/2 phosphorylation mediated b

91 sruption of other zebrafish rab5 genes shows little or no effect on expression of markers of dorsal o

92 rait (dw) in peach (Prunus persica) that has little or no effect on fruit development.

93 of non-BBB CNS ECs to a BBB-like state, has little or no effect on gene expression or chromatin acce

94 ected 2893 splicing QTLs, most of which have little or no effect on gene-level expression.

95 xpression of EXTL2 in the same cell line had little or no effect on heparan sulfate chain length.

96 uine, lopinavir, and interferon regimens had little or no effect on hospitalized patients with Covid-

97 spects of terminal dendrite development with little or no effect on major dendrite patterning.

98 At equivalent TSS, cluster exposure had little or no effect on malic acid concentration.

99 Maternal nutrition has little or no effect on many nutrients in human milk; for

100 cis QTLs that affect protein abundance with little or no effect on messenger RNA or ribosome levels,

101 there was low-strength evidence that P4P had little or no effect on patient health outcomes and a pos

102 ressure on the response of these sensors had little or no effect on potential, sensitivity, or limit

103 metastasis in two orthotopic models, but had little or no effect on primary tumor growth.

104 There was little or no effect on sensitivity to suramin and pyrido

105 Metformin had no effect on cIMT and little or no effect on several surrogate markers of card

106 versification; some adaptive radiations have little or no effect on speciation, or even a negative ef

107 removed by null mutation, these peptides had little or no effect on stress-induced sleep.

108 ven at concentrations up to 10,000 mug/L had little or no effect on sugar utilisation, alcohol produc

109 curring in response to these stimuli but had little or no effect on that of p38 MAPK or PI3K.

110 ly blocked KSHV lytic replication but showed little or no effect on the antiapoptotic and antiautopha

111 ncreased the variability of spike times with little or no effect on the average firing rate.

112 Inhibition of DBR1 had little or no effect on the formation of minus-strand str

113 Thus, temperature had little or no effect on the hydrolytic rate in dilute sub

114 trated that propargylglycine (PAG, 1 mm) had little or no effect on the NPV caused by PGF2alpha or LY

115 sion of hTetherin in hematopoietic cells had little or no effect on the number of MoMLV-infected sple

116 he same manipulations in mature animals have little or no effect on the same property.

117 e of both proteins during postnatal life has little or no effect on the survival and function of cone

118 ted growth of the cerebellar vasculature and little or no effect on the vasculature elsewhere in the

119 virus, and 21.9% reported that COVID-19 had little or no effect on their daily routine.

120 However, mutations of these residues had little or no effect on toxin block of the alpha9alpha10

121 -fostering [4] and parental absence [5] have little or no effect on vocal development.

122 however, deletion of LGR5 in stem cells has little or no effect on Wnt/beta-catenin signaling or cel

123 t treatment options for these disorders have little or no effect upon motivational impairments.

124 We found that lidocaine also has little or no effect when applied intracellularly in whol

125 ine delivery after the onset of epidemic has little or no effect, regardless of the population demogr

126 ent and the allele from the other parent has little or no effect.

127 ereas depletion of other CNOT components had little or no effect.

128 s lowered the oxygen affinity of HbS but had little or no effects on autoxidation or heme loss kineti

129 relapsing-remitting multiple sclerosis have little or no efficacy in progressive multiple sclerosis

130 rved for influx; 3) mutant Glu325 - Ala does little or no efflux in the absence or presence of DeltaP

131 7 domain containing fusion proteins had very little or no endonuclease activity, despite the presence

132 rie sweeteners (LCSs) provide sweetness with little or no energy.

133 , to search movements during which there are little or no environmental cues.

134 red trials with experimental drugs that have little or no established efficacy or safety data.

135 While in agreement with previous studies, little or no evidence for clonal (SF3B1 mutation) involv

136 We observed little or no evidence of associations between low prenat

137 formation, while hairpin formation exhibits little or no evidence of friction.

138 Little or no evidence suggesting more or less than addit

139 We and others have found little or no evidence that these cells differentiate int

140 We used the Delphi method when little or no evidence was available.

141 nostic accuracy of tests for celiac disease, little or no evidence was identified to inform most of t

142 t, those with only 1 of these exposures have little or no excess risk after controlling for conventio

143 e vocalizations have been thought to undergo little or no experience-dependent acoustic changes durin

144 erties of genes and gene products containing little or no experimental annotation.

145 eactions, but the literature reports provide little or no experimental evidence for this.

146 plication to the thousands of chemicals with little or no exposure data.

147 ession (ZII+) interdigitated with stripes of little or no expression (ZII-).

148 tion of endothelial cells, whereas there was little or no expression in synovium from healthy donors.

149 nlike B cells, circulating monocytes express little or no FcgammaRIIb.

150 s, either alone or in combination, generated little or no force in the I3 muscle.

151 ghest for women who were black or brown with little or no formal education (48.8%, 95% CI 48.2-49.5)

152 y for general health-care professionals with little or no formal mental health training.

153 is no exception; but most biologists receive little or no formal preparation for the increasingly com

154 generally tailored to act as spectators with little or no function.

155 Although most of these mutations are of little or no functional consequence, a mutation may aris

156 ed and subsequent site dissociation required little or no further ATP hydrolysis.

157 omic analysis revealed a deep divergence and little or no gene flow between Apis and Bombus gut symbi

158 Little or no genetic association with disease behaviour

159 een to be capable of occurring abruptly with little or no genetic change, with involvement of the ext

160 tic region, the transition was gradual, with little or no genetic input from incoming farmers [7].

161 evolutionary change, for example if there is little or no genetic variance in number of grandoffsprin

162 otential; (ii) near-maximal glycolysis, with little or no glycolytic reserve; (iii) marked ketogenesi

163 We detected little or no H1N1pdm replication in animals that receive

164 g patients who are ethnic minorities or have little or no health insurance.

165 The mutants produce little or no hemozoin (Hz), the detoxification by-produc

166 large deletions (median size, ~100 bp) with little or no homology at deletion junctions.

167 versely, cyclic stretching of DAP-DNA showed little or no hysteresis, consistent with the adoption of

168 expressed at the plasma membrane, transport little or no I(-) These residues are conserved throughou

169 We found that tumours with little or no immune infiltration were associated with di

170 The designs elicit little or no immune response and provide potent prophyla

171 rmining region (CDR) methionine residues had little or no impact on antigen binding of the antibody.

172 ogues (NA) may suppress HBV replication with little or no impact on cccDNA, hence lifelong treatment

173 system, we found that local realignment had little or no impact on SNP calling, but increased sensit

174 The APOE phenotype had little or no impact on the associations.

175 ings and likely reduce patient anxiety, with little or no impact on the quality of care.

176 supraphysiological levels (0.4 ppm) had very little or no impact on worm expulsion.

177 type of peer review and reviewer gender had little or no impact.

178 Little or no improvement is obtained when using meta-dat

179 to CO2 and climate, as this model simulates little or no increase in drought frequency.

180 eurodegenerative diseases, in which there is little or no infiltration of blood-derived immune cells

181 lineages that lack placentas; while there is little or no influence of male traits on the evolution o

182 g, whereas the AC413/rAmy C-terminal Tyr had little or no influence on binding.

183 nt allergenic proteins are standardized with little or no information about compositional differences

184 location of the stimulus, but they provided little or no information about orientation independently

185 ble socialtaxis settings, where agents share little or no information and rely on simple computations

186 er to the thermodynamically stable forms but little or no information is supplied about their complex

187 he acute contact toxicity of acaricides with little or no information on the behavioral responses eli

188 ivity of Fusarium avenaceum myosin-1 but has little or no inhibitory effect on the motor activity of

189 erable conservation among hBests, hBest1 has little or no interaction with other hBests or mTMEM16A.

190 domains (TADs), interspersed with regions of little or no interaction, in interphase nuclei.

191 locations, renew in different ways, and show little or no interconversion.

192 om unfertilized and early stage eggs possess little or no intrinsic transcriptional activity.

193 ania, Kenya, Uganda), whereas others receive little or no investments (Sierra Leone, Central African

194 oxygen reduction in the oxic zone show very little or no label uptake.

195 ismutase (SOD1), G85R SOD1YFP and G93A SOD1, little or no lipofuscin was detected in motor neuron cel

196 ymphomas and Burkitt lymphomas often express little or no LMP1.

197 Immunofluorescence experiments showed little or no localization of cMyBP-C(C10mut) to the C-zo

198 ontrast, the enteric nervous system displays little or no loss of cholinergic neurons.

199 e rarely and back-cross bidirectionally with little or no loss of fitness under conditions of plentif

200 which have increased drought tolerance, with little or no loss of nutrient uptake.

201 s carriers of loss-of-function mutations had little or no Lp(a) and increased the risk of T2D.

202 acterize protein interaction interfaces with little or no lysine residues.

203 These findings suggest that histones carry little or no memory of the heterochromatin state through

204 l amides with a variety of nucleophiles with little or no modification.

205 For example, many larvae display little or no movement.

206 ly expressed in the auditory brainstem, with little or no mRNA for Kv3.2 or Kv3.4.

207 and flow was observed even in subjects with little or no nausea.

208 red in mouse embryonic stem cells expressing little or no NEAT1 RNA, suggesting that PS-ASOs can serv

209 , cotton pollen, and cotton nectar contained little or no neonicotinoids resulting from insecticide s

210 f various proteins, including those carrying little or no net electric charges, is demonstrated.

211 Cochlear removal in older animals results in little or no neuron death.

212 Nevertheless, our estimates suggest that little or no new CO(2)-emitting infrastructure can be co

213 lity to be targeted for cellular uptake with little or no non-specific binding.

214 There was little or no non-specific desensitization when lung mast

215 patients with post-cholecystectomy pain and little or no objective abnormalities on investigation, s

216 s in the genome of a model organism may have little or no observable impact on its wild type phenotyp

217 ry associations (OW) (e.g. "banana") or with little or no olfactory associations (CW) (e.g. "chair")

218 According to current dogma, there is little or no ongoing neurogenesis in the fully developed

219 Quiescent galaxies with little or no ongoing star formation dominate the populat

220 a peripheral injury and/or inflammation but little or no pain.

221 s growth factors outside the PDGF family but little or no PDGFs, promoted formation of a unique SFK-P

222 n telomeric repeat sequence, where it causes little or no perturbation of DNA structure or stability.

223 plants inventoried at our nurseries provided little or no pollen to honey bees.

224 jority of ornamental plant varieties receive little or no pollinator visitation.

225 ant rotavirus vaccines were excluded because little or no post-licensure data were available.

226 the more epidemic periphery, which exhibits little or no postmonsoon outbreak in a pattern typical o

227 uggestion that they are viral remnants, with little or no potential to reactivate.

228 rofitable harvesting to extinction even with little or no price increase; and some high-value declini

229 periencing a first episode of psychosis with little or no prior antipsychotic exposure, and how poten

230 ction in the many real-life situations where little or no prior knowledge is available about the char

231 Here we reconstruct spatial positions with little or no prior knowledge, by searching for spatial a

232 Surprisingly, adult human beta-cells express little or no PRLR.

233 30L, 30-IXAla, 30-620A, or 30-622A contained little or no processed viral DNA.

234 idene decomposition is so fast that there is little or no product formation, it is best that ethylene

235 documentation, an interface for users, with little or no programming experience, to 'talk' to the se

236 ted for an extended polypeptide chain having little or no propensity to form persistent structures.

237 till regarded as scientific curiosities with little or no prospect of generating practical to use med

238 Little or no protection was conferred by mouse tail tip

239 antigen-specific CD4 T cells have conferred little or no protection.

240 All mutants, except Q56I, showed little or no [PSI+] transmission barrier from the refere

241 ce daily in the morning for 8 days, produced little or no quantifiable systemic exposure to the paren

242 s frequent and successful use in the clinic, little or no radiobiologic considerations are made at th

243 ext] of observable genome, in which there is little or no recombination.

244 b or in Clec4n(-/-) mice was associated with little or no reduction in lung-draining lymph node cells

245 Single mutants had little or no reduction in overall fertility, whereas dou

246 ure and are highly drought tolerant but show little or no reduction in shoot nitrogen concentrations

247 en a success or has picked-up sequences with little or no relationship to the query.

248 (BACs) containing Spirodela DNA inserts with little or no repetitive elements as probes for multicolo

249 ation in NS5A was more limited but exhibited little or no requirement for expression of functional NS

250 inhA promoters), and three genes contributed little or no resistance (gyrB, tlyA, and the ahpC promot

251 sting that local protection of reefs affords little or no resistance to extreme heat.

252 o inhibit vaginal transmission of HIV-1 with little or no resistance to RPV but could not inhibit vir

253 d efficiently regardless of noise level with little or no resolution loss.

254 mall object darker than the background, with little or no responses to static flicker, vertically elo

255 denylases, but highly purified NOC possesses little or no ribonuclease activity.

256 h and rupture rates and very small UIAs have little or no risk for rupture.

257 ikely to provoke seizures, while others pose little or no risk.

258 IgaB appears to play little or no role in adherence or invasion but is requir

259 irectly activated DCs are considered to play little or no role in T cell immunity.

260 ty of this transformation, with MoaC playing little or no role in the pyranopterin formation.

261 cts not present in the folded structure play little or no role in the self-assembly mechanism.

262 However, many gene models appear to play little or no role in the traits of an organism.

263 PKA-mediated phosphorylation of RyRS2808 has little or no role in these alterations.

264 nd occurrence of lymph node metastases while little or no Runx2 phosphorylation was seen in normal pr

265 rometric analysis of biological samples with little or no sample preparation.

266 of the ore zone and down-gradient wells have little or no Se oxyanions.

267 d, the posterior color-biased regions showed little or no selectivity for object shape or for particu

268 trary to S. meliloti, S. fredii HH103 showed little or no sensitivity to Medicago NCR247 and NCR335 p

269 er than 1 kbp, of which 3,761 are novel with little or no sequence homology in any existing databases

270 to correctly identify analogous folds where little or no sequence homology information is.

271 licable to cellular mRNA IRES that also have little or no sequences/structures in common.

272 We found little or no sex difference in these measures, suggestin

273 e ore body, whereas two other transects show little or no sign of reduction in the down-gradient regi

274 unique to the plant RNAse J proteins, had a little or no significant effect.

275 cted with the 263K hamster prion strain have little or no signs of mitochondrial dysfunction at the d

276 Genes escaping XCI show little or no silencing during early propagation of XCI.

277 where there is partial fast inactivation but little or no slow inactivation.

278 Conventional chemotherapy has little or no specificity for cancer cells, normally resu

279 dical sites in these biradicals lead to very little or no spin-spin coupling, and no suppression of r

280 "molecular ruler." Second, the method yields little or no spurious signal even with highly abundant c

281 ytes and nonpermeabilized WT myocytes showed little or no staining, without striation.

282 Readers with little or no statistical knowledge would be expected to

283 Trials primarily included adolescents with little or no substance use.

284 In contrast, there was little or no such protective effect in the town populati

285 As a result, little or no sunlight reaches the surface for over a yea

286 Thus, lipid-anchored syb2 provides little or no support for exocytosis, and anchoring syb2

287 With this device only little or no supporting electrolytes are needed, making

288 s awareness of hypoglycemia, preferably with little or no symptomatic or even asymptomatic hypoglycem

289 however, approximately 25% of patients show little or no symptomatic response.

290 Surprisingly there was little, or no synergistic interaction observed when apic

291 hted images were scored as lymphatic type 1 (little or no T2 mediastinal and supraclavicular signal)

292 The O states of different amides show little or no temporal correlation, even if adjacent resi

293 or cVMS in a range of aquatic organisms show little or no toxic effects up to solubility limits in wa

294 cles (nC60), fullerol, TiO2, and CeO2 showed little or no toxicity.

295 oach to any species, particularly those with little or no trans-regulatory data.

296 We observed little or no transport, however, through neuromodulatory

297 ide (fault hanging wall), with comparatively little or no uplift of the mountainside (fault footwall)

298 ied: 49% of Veterans had Rapid Recovery with little or no use of care; 15% had a Steady Recovery with

299 ds and/or optic canal decompression provided little or no vision return (P = .05).

300 , which will be grown on marginal lands with little or no water input.