ライフサイエンスコーパス: lncRNA

1 lncRNA control of PHO gene expression is influenced by t

2 lncRNA interactome, RNA immunoprecipitation, and coimmun

3 lncRNA transcription across the PHO mRNA promoters displ

4 lncRNA-MAP3K4 and MAP3K4 show coordinated expression in

5 lncRNA-MAP3K4 knockdown reduced the expression of key in

6 lncRNA-MAP3K4 shares a bidirectional promoter with MAP3K

7 lncRNAs and the user-friendly nomogram could facilitate

8 lncRNAs are a category of cellular RNAs that are longer

9 lncRNAs are notably abundant in brain; however, their ne

10 sembly was developed that identified ~69,000 lncRNA gene loci.

11 d 24 h salt treatment, respectively and 1820 lncRNAs in Sarakhs, a salt sensitive cultivar, after 6 h

12 matically knocked down the expression of 285 lncRNAs in human dermal fibroblasts and quantified cellu

13 associated with higher tumor-grade while 3/5 lncRNAs were also associated with no tumor capsule.

14 All 5 lncRNAs and 85/91 (93.4%) of the correlated genes were s

15 Our analysis identified 675 lncRNAs differentially expressed between the two ecotype

16 nter counter-defense strategy activated by a lncRNA in response to the viral suppression of the prima

17 We propose that SNHG7 is a lncRNA oncogene that is controlled by growth factor sign

18 HOTAIR is a lncRNA overexpressed in several epithelial cancers and s

19 utlook on how the functional mechanisms of a lncRNA gene can be determined.

20 y provides an interesting demonstration of a lncRNA-mediated mechanism for active AKT-driven EMT-inde

21 These data provide evidence on a lncRNA-based strategy to effectively impair the function

22 We identify SWINGN, a lncRNA interacting with SMARCB1 exclusively in prolifera

23 anism of this association might be through a lncRNA-regulated effect on LRRK2 expression because LINC

24 hese results highlight a mechanism whereby a lncRNA promotes myogenesis by enhancing the interaction

25 ationship, determining cis- and trans-acting lncRNAs in vivo, and generating new developments in high

26 Although lncRNAs do not encode proteins, they play numerous funct

27 Although lncRNAs have been shown to function in diverse pathophys

28 Among them, we found amplified lncRNA associated with lung cancer-1 (ALAL-1) as frequen

29 Here, we revealed LINC00313, an lncRNA upregulated during KSHV lytic reactivation, as a

30 n this study, we investigated the role of an lncRNA called AW112010.

31 hese data suggest that the interaction of an lncRNA with EZH2 can alter the affinity of EZH2 for its

32 maintenance of chromosome length requires an lncRNA (e.g., hTERC) and two lncRNAs in the ribosome tha

33 These results demonstrate that an lncRNA serves as a novel connector in HIV-KSHV interacti

34 We found that an lncRNA, named GABPB1-AS1, was significantly upregulated

35 ells, we identified novel protein-coding and lncRNA genes regulated by FOXA1.

36 ct regulatory link between this enhancer and lncRNAs PCAT1, PRNCR1 and PVT1.

37 Putative tumor-promoting genes and lncRNAs defined using BGRDs are experimentally verified

38 BCL6, RRM2B, IDO1, FTH1, APIP, and LRIG2 and lncRNAs NEAT1 and FTX.

39 or the efficient nuclear export of mRNAs and lncRNAs that are generated from short transcripts that t

40 port of intronless and intron-poor mRNAs and lncRNAs.

41 ved small protein encoded by a mis-annotated lncRNA that regulates apoptosis and tumorigenicity in we

42 iomas, nine of these hits are prioritized as lncRNA Glioma Radiation Sensitizers (lncGRS).

43 lement (SINE) in Malat1, a cancer-associated lncRNA, to investigate its significance in cellular phys

44 predicted function of an obesity-associated lncRNA, LINC01018, in regulating the expression of genes

45 T, we identify that VAL (Vimentin associated lncRNA, LINC01546), which is directly induced by AKT/STA

46 diction and prioritization of ASD-associated lncRNAs.

47 ying the identification of cancer-associated lncRNAs and highlight important considerations for evalu

48 thus highlighting the complexity present at lncRNA loci.

49 MAARS (Macrophage-Associated Atherosclerosis lncRNA Sequence).

50 Because lncRNA loci can contain multiple modes of action, we wan

51 Despite such differences, both lncRNAs demonstrate robust binding to CTCF, a protein th

52 nformations in solution, revealing that Bvht lncRNA has a well-defined, albeit flexible 3-D structure

53 chine learning approach to predict candidate lncRNAs associated with ASD.

54 functional characterization of the candidate lncRNAs associated with ASD.

55 Characterizing lncRNA expression across cells and tissues is key to und

56 protein turnover by the proteasome complex, lncRNAs are also likely to exist in a dynamic equilibriu

57 ed the anti-apoptotic evolutionary conserved lncRNA Sarrah, which is downregulated by aging, as a reg

58 FAST is a positionally conserved lncRNA but is not conserved in its processing and locali

59 Whether conserved lncRNAs undergo conserved processing, localization, and

60 at increased MAFG signaling during DIO curbs lncRNA expression.

61 TNFalpha- and NF-kappaB-induced cytoplasmic lncRNA that specifically interacts with SART3, regulatin

62 lated to cardiometabolic traits, then define lncRNA's function and specific target genes by integrati

63 Here we determine lncRNA localization using biotinylated locked nucleic ac

64 ng noncoding RNAs (lncRNAs) and discriminate lncRNA loci that produce functional RNAs from those whos

65 rm the prognostic value for several enhancer lncRNAs expression in cancer.

66 GRS-1, a primate-conserved, nuclear-enriched lncRNA, inhibits the growth and proliferation of primary

67 3-D atomistic structural study of epigenetic lncRNA, Braveheart (Bvht), and its complex with CNBP (Ce

68 ance, and therapeutic importance of exosomal lncRNAs in cancer biology.

69 es previously unknown Y chromosome-expressed lncRNA regulators of radiation response in male NSCLC an

70 Three differentially expressed lncRNAs (ENST00000497872, n333737, and n335265) were ide

71 natures in clinically-relevant co-expression lncRNA-mRNA networks residing in pertinent cancer pathwa

72 phosphate-replete conditions by 5' flanking lncRNAs prt, prt2, and nc-tgp1, respectively.

73 (lnc) RNAs, there are many opportunities for lncRNA synthesis to negatively affect a neighboring prot

74 uggest a new, to our knowledge, paradigm for lncRNA-mediated modulation of lymphocyte activation and

75 ere, we constructed a reference sequence for lncRNAs in P. vera (Pistacia vera L.) with 53220 transcr

76 ughput screening used to identify functional lncRNAs.

77 Here, we report aberrant expression of H19 lncRNA and TET1 in endothelial cells (ECs) of human athe

78 e find that human JPX and its mouse homolog, lncRNA Jpx, have deep divergence in their nucleotide seq

79 Collective results reveal how lncRNA effectively replaces a DNA repair protein for eff

80 sociated gene regulatory activities, but how lncRNAs are distinguished from other RNAs and recruit ef

81 mRNA, and provide molecular insight into how lncRNAs are recruited to regulatory sites to carry out c

82 aging screen targeting more than 2,000 human lncRNAs, we identify numerous lncRNAs involved in key st

83 the in vivo function of non-conserved human lncRNAs.

84 mportance and mechanisms of action for human lncRNAs are largely unknown.

85 ce, it remains largely unknown whether human lncRNAs have such in vivo functions.

86 g lncRNAs in mice macrophages, we identified lncRNA 1810058I24Rik, which was downregulated in both hu

87 es with clinical characteristics to identify lncRNA signatures in clinically-relevant co-expression l

88 Here, we identify lncRNA LUCAT1 which is upregulated in human myeloid cell

89 We first identify lncRNAs with high function potential using multiple indi

90 Here, we identify lncRNAs frequently lost or amplified in cancer.

91 ream lncRNAs and are sensitive to changes in lncRNA 3' processing/termination.

92 d a hitherto uncharacterized hypoxia-induced lncRNA RAB11B-AS1 in breast cancer cells.

93 feeding, whilst nutrient deprivation induced lncRNAs in mouse liver.

94 ere, we present a novel approach integrating lncRNA-mRNA expression profiles with clinical characteri

95 reactivation, as a novel HIV Tat-interacting lncRNA that potentially mediates HIV-KSHV interactions.

96 In the aortic intima, lncRNA-MAP3K4 expression was reduced by 50% during the p

97 nes, particularly for antisense and intronic lncRNAs.

98 ses through differential deregulation of key lncRNAs affecting important gene network in key cancer p

99 The identification of these key lncRNAs signatures that deregulate important network of

100 icropeptide encoded by a Y chromosome-linked lncRNA that may explain the higher incidence of esophage

101 In contrast to coding genes, many lncRNAs were specifically transcribed in one ecotype and

102 In particular, many lncRNAs are genetically or epigenetically deregulated in

103 Mechanistically, lncRNA-MAP3K4 regulates inflammation through the p38 MAP

104 Integrative analyses of mRNAs, miRNAs, lncRNAs, chromatin accessibility and cis-regulatory elem

105 that mammalian genomes encode thousands more lncRNAs.

106 The mouse lncRNA Jpx has been shown as an essential regulator in X

107 Here, we compared transcriptomes (mRNAs, lncRNAs, and small RNAs) of root tips from these two eco

108 e we identify SAM (Sugt1 asssociated muscle) lncRNA that is enriched in the proliferating myoblasts.

109 s well as terminate transcription of nascent lncRNAs and mRNAs, Lee and Mendell (2020) and Lai et al.

110 y, these findings unveil the role of a novel lncRNA in vascular inflammation by cis-regulating MAP3K4

111 vely, these data show that PRANCR is a novel lncRNA regulating epidermal homeostasis and identify oth

112 These findings show that a novel lncRNA SCIRT counteracts breast tumorigenesis by opposin

113 We identify a novel lncRNA termed lncRNA-MAP3K4 that is enriched in the vess

114 diate the differential expression of a novel lncRNA that acts on MAOA expression to regulate impulsiv

115 Altogether, our study demonstrates a novel lncRNA-based molecular mechanism of cocaine action.

116 Here, we identified the novel lncRNA GRASLND (originally named RNF144A-AS1) as a regul

117 l roles of both known coding genes and novel lncRNAs.

118 We applied CARPID to the nuclear lncRNA XIST, and it captured a list of known interacting

119 Nuclear and non-nuclear lncRNAs regulate a host of biological processes, and whe

120 r, the molecular mechanisms by which nuclear lncRNAs directly contribute to DNA damage responses rema

121 an 2,000 human lncRNAs, we identify numerous lncRNAs involved in key steps of cell division such as c

122 Analysis of lncRNA 1810058I24Rik subcellular localization revealed t

123 nadequacy of the bioinformatic definition of lncRNA, which excludes those lncRNA gene loci with small

124 equencing analysis following deregulation of lncRNA NPC48 revealed a potential link with root growth

125 lines and tumor tissues, and the function of lncRNA in CC was investigated in vitro and in vivo.

126 Like the functions of lncRNA transcripts, the mechanisms that underlie these g

127 nse to metabolic stress through induction of lncRNA Gm15441.

128 We find that invasion of lncRNA transcription into the downstream gene body incor

129 Accurate prediction of lncRNA-disease associations can provide a new perspectiv

130 n by investigating fundamental properties of lncRNA genes, revealing new insights into the RNA struct

131 In this study, we investigated the role of lncRNA FENDRR in human and mouse macrophage polarization

132 eviously unrecognized and functional role of lncRNA GATA6-AS1 in controlling human cardiomyocyte diff

133 llance factors and discuss the vital role of lncRNA surveillance in orchestrating various biological

134 The transcription start sites of lncRNA gene loci tend to be close to their nearest prote

135 foundation for future structural studies of lncRNA-protein complexes.

136 ave been mostly attributed to the ability of lncRNAs to function as regulatory noncoding transcripts,

137 and detailed functional characterization of lncRNAs within the genome.

138 pport a model for functional conservation of lncRNAs independent from sequence and structural diverge

139 HPV16 E6-induced differential expression of lncRNAs, miRNA, and mRNA were identified using microarra

140 A significantly higher fraction of lncRNAs is localized in the cytoplasm of hESCs than in m

141 Here we show that a high fraction of lncRNAs, but not protein-coding mRNAs, are repressed dur

142 However, the biological function of lncRNAs in HPV16-related CC remains largely unexplored.

143 The functions of lncRNAs are often mediated through associated gene regul

144 The immunoregulatory functions of lncRNAs have been revealed primarily in murine models wi

145 ces the chromatin association of hundreds of lncRNAs and unstable transcripts, without altering the o

146 extract the global and local information of lncRNAs and diseases through considering the disease sem

147 However, the vast majority of lncRNAs have not been tested as potential therapeutic ta

148 depict that hypomethylation of promoters of lncRNAs play a pivotal role in cancer progression, sugge

149 ic regulation, transcriptional regulation of lncRNAs, and their important role in tumor progression a

150 eal-time PCR (qRT-PCR) experiment results of lncRNAs, pre-miRNAs and mature miRNAs were in accordance

151 Furthermore, we discuss the role of lncRNAs in exosomes and their function in drug resistanc

152 We investigate the role of lncRNAs in gene activation by profiling the RNA interact

153 Given the importance regulatory roles of lncRNAs, providing methods for predicting the function o

154 ed changes in the targeting and spreading of lncRNAs on chromatin.

155 alters the expression levels of a subset of lncRNAs.

156 We identified thousands of lncRNAs that were largely conserved at the DNA level in

157 Our work highlights extensive translation of lncRNAs during hESC pancreatic differentiation and provi

158 murine models with limited understanding of lncRNAs in human immune responses.

159 We have thus unveiled a pro-oncogenic lncRNA that mediates cancer immune evasion, pointing to

160 ircDeep, to classify circular RNA from other lncRNA.

161 ing epidermal homeostasis and identify other lncRNA candidates that may have roles in this process as

162 for distinguishing circular RNAs from other lncRNAs due to difficulty of classification.

163 alization of both nascent and polyadenylated lncRNA transcripts to chromatin, and disrupts the nuclea

164 enetic manipulations that favor 'precocious' lncRNA 3'-processing/termination upstream of the mRNA pr

165 em cell models to demonstrate that a primate lncRNA, BANCR, is primarily expressed in fetal cardiomyo

166 erm differentiation and suggest that protein-lncRNA phase-separated condensates have a broader role a

167 l of endogenous proteins encoded by putative lncRNAs have been identified and assigned a function.

168 stablishing the coding potential of putative lncRNAs and describe various functions of known micropep

169 ults identify PRECSIT as a new p53-regulated lncRNA, which promotes progression of cSCC via STAT3 sig

170 he extent to which developmentally regulated lncRNAs are translated and whether the produced micropro

171 Another network comprising 4 down-regulated lncRNAs and 8 down-regulated metallothionein-family gene

172 SPRi) to the identification of MYC-regulated lncRNAs that are required for MYC-driven cell proliferat

173 oorer prognosis, comprises five up-regulated lncRNAs significantly correlated (|Pearson Correlation C

174 lating, drug-resistant and prognosis-related lncRNA biomarkers; (ii) 11 418 somatic mutation-ceRNA ev

175 with a pivotal function of the tumor-related lncRNA HOTAIR, comprising a dominant negative mutant tha

176 NAs showed that at least two ecotype-related lncRNAs regulate primary root growth in ecotype Columbia

177 s, revealed that salt responsive NAT-related lncRNAs associated with transcription factors, CERK1, LE

178 lts illustrate that an angiogenic repressive lncRNA, LINC00313, which is upregulated during KSHV reac

179 This study shows how a p53-responsive lncRNA mediates chemotherapeutic response by modulating

180 we identified 1909 and 2802 salt responsive lncRNAs in Ghazvini, a salt tolerant cultivar, after 6 a

181 located within BANCR, a long non-coding RNA (lncRNA) exclusively expressed in primate fetal cardiomyo

182 While long non-coding RNA (lncRNA) genes have attracted a lot of attention in the l

183 Herein, based on long non-coding RNA (lncRNA) profiling induced by active AKT, we identify tha

184 cific 1 (HOTAIRM1) is a long non-coding RNA (lncRNA) that plays a pivotal role in regulating myeloid

185 egulator (lincNMR) is a long non-coding RNA (lncRNA) which is induced in hepatocellular carcinoma.

186 romoter of LOXL1-AS1, a long non-coding RNA (lncRNA).

187 ation and binding to the long noncoding RNA (lncRNA) BACE1-antisense transcript (BACE1-AS), resulting

188 e identified the nuclear long noncoding RNA (lncRNA) H19X as a master regulator of TGF-beta-driven ti

189 ghlights the role of the long noncoding RNA (lncRNA) KCNQ1OT1 in fracture healing.

190 dependent isoform of the long noncoding RNA (lncRNA) Pvt1, expressed 50 kb downstream of Myc, which b

191 f Y chromosome-expressed long noncoding RNA (lncRNA) that are involved in male non-small cell lung ca

192 V reactivation-activated long noncoding RNA (lncRNA) that interacts with HIV Tat.

193 ly controlled by a novel long noncoding RNA (lncRNA) that we named Stem Cell Inhibitory RNA Transcrip

194 We report that a long noncoding RNA (lncRNA), H19, associates with dystrophin and inhibits E3

195 produced from a putative long noncoding RNA (lncRNAs) that is important in controlling innate immunit

196 Of the thousands of long noncoding RNAs (lncRNA) identified in lymphocytes, very few have defined

197 induces a vast array of long noncoding RNAs (lncRNA) in breast cancer cells, but their biological fun

198 tion and regulation of long non-coding RNAs (lncRNAs) are associated with various human diseases.

199 Long non-coding RNAs (lncRNAs) are components of epigenetic control mechanisms

200 the majority of human long non-coding RNAs (lncRNAs) are considered non-conserved.

201 Long non-coding RNAs (lncRNAs) are defined as non-protein-coding transcripts t

202 Long non-coding RNAs (lncRNAs) are emerging regulators of pathophysiological p

203 Long non-coding RNAs (lncRNAs) are important regulators of development.

204 Long non-coding RNAs (lncRNAs) are often aberrantly expressed in Hepatocellula

205 nes code for proteins, long non-coding RNAs (lncRNAs) as essential regulators of gene expression have

206 Long non-coding RNAs (lncRNAs) exhibit highly cell type-specific expression an

207 e our understanding of long non-coding RNAs (lncRNAs) in primary colon cancer, their role in mCRC and

208 g proteins of specific long non-coding RNAs (lncRNAs) in the native cellular context.

209 spreading patterns of long non-coding RNAs (lncRNAs) on chromatin requires a technique that can dete

210 as microRNAs (miRNAs), long non-coding RNAs (lncRNAs) or circular RNAs (circRNAs) can be selectively

211 Long non-coding RNAs (lncRNAs) play an important role in gene regulation and a

212 DNA complexes, so how long non-coding RNAs (lncRNAs) regulate DNA repair is less well understood.

213 nd that there are more long non-coding RNAs (lncRNAs) than protein coding genes, several of which are

214 Here, we report that long non-coding RNAs (lncRNAs), a recently discovered class of regulatory tran

215 n identified, including long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs).

216 igated the potential of long noncoding RNAs (lncRNAs) and corresponding predictive models to diagnose

217 unctionally interrogate long noncoding RNAs (lncRNAs) and discriminate lncRNA loci that produce funct

218 Long noncoding RNAs (lncRNAs) and promoter- or enhancer-associated unstable t

219 g up- and downregulated long noncoding RNAs (lncRNAs) and transcriptional regulators, and used in sit

220 Long noncoding RNAs (lncRNAs) are a heterogenous group of RNAs, which can enc

221 Long noncoding RNAs (lncRNAs) are a major component of the noncoding genome,

222 Long noncoding RNAs (lncRNAs) are crucial in many cellular processes, yet rel

223 ironment, since several long noncoding RNAs (lncRNAs) are known to quantitatively regulate gene expre

224 Long noncoding RNAs (lncRNAs) are often associated with polysomes, indicating

225 global emergencies and long noncoding RNAs (lncRNAs) are regulatory transcripts with elusive functio

226 known for decades that long noncoding RNAs (lncRNAs) can play essential functions across most forms

227 Long noncoding RNAs (lncRNAs) evolve more rapidly than mRNAs.

228 he dysregulation of the long noncoding RNAs (lncRNAs) expression.

229 Long noncoding RNAs (lncRNAs) have been demonstrated to play important regula

230 Long noncoding RNAs (lncRNAs) have been identified in all eukaryotes and are

231 ifically, some putative long noncoding RNAs (lncRNAs) have been misannotated as noncoding.

232 Long noncoding RNAs (lncRNAs) have been revealed to play critical roles in a

233 Long noncoding RNAs (lncRNAs) have emerged as key coordinators of biological

234 Long noncoding RNAs (lncRNAs) have emerged as key regulators in a variety of

235 Long noncoding RNAs (lncRNAs) have emerged as putative biomarkers and therape

236 The roles of long noncoding RNAs (lncRNAs) in musculoskeletal development, disease, and re

237 Long noncoding RNAs (lncRNAs) localize in the cell nucleus and influence gene

238 anscription factors and long noncoding RNAs (lncRNAs) that regulate gene expression.

239 ated protein-coding and long noncoding RNAs (lncRNAs), some of which are regulated in specific cell t

240 ion of large numbers of long noncoding RNAs (lncRNAs).

241 Analysis of Drosophila roX2 lncRNA using this approach revealed that heat shock, unl

242 ntisense oligonucleotides targeting the same lncRNAs exhibited global concordance, and the molecular

243 with nuclear paraspeckles, whose scaffolding lncRNA NEAT1 is dramatically upregulated in stressed neu

244 ve target genes related to top five selected lncRNAs showed their involvement in the regulation of AT

245 and global information of disease semantics (lncRNA functions) respectively.

246 Recent work on several lncRNAs genes demonstrates that not only is the produced

247 esis, has been found associated with several lncRNAs, although it is unknown whether these interactio

248 Some lncRNAs show altered expression levels in autistic brain

249 rm a comprehensive identification of soybean lncRNAs.

250 ng transcriptome identified ecotype-specific lncRNA-mediated regulation in root apexes.

251 h a mechanism by which a macrophage-specific lncRNA interacting with HuR regulates apoptosis, with im

252 ions, here we identify a macrophage-specific lncRNA MAARS (Macrophage-Associated Atherosclerosis lncR

253 f a putative gastrointestinal-tract-specific lncRNA (LINC00675) that is regulated by the pioneer tran

254 that the in vivo function of human-specific lncRNAs can be successfully examined in the humanized mo

255 ditions by transcription of an upstream SRG1 lncRNA that traverses the SER3 promoter and elicits occl

256 By studying lncRNAs in mice macrophages, we identified lncRNA 181005

257 We genetically ablated ten such lncRNAs, most of them translated, and found that nine ar

258 In summary, lncRNAs have a great potential to consider them as novel

259 We identify a novel lncRNA termed lncRNA-MAP3K4 that is enriched in the vessel wall and re

260 transcripts, there is growing evidence that lncRNAs may also encode functional micropeptides.

261 Given that lncRNAs are emerging as key players in tissue physiology

262 We hypothesize that lncRNAs modulate HCC prognoses through differential dere

263 Our analyses show that lncRNAs containing cryptic introns are targeted by the c

264 We showed that lncRNAs are distinct from both protein-coding transcript

265 Accumulating evidence suggests that lncRNAs have the potential to be promising diagnostic, p

266 n profile kernel similarity (DISGS), and the lncRNA-disease interaction (LNCDIS).

267 the disease semantic similarity (DISSS), the lncRNA function similarity (LNCFS), the lncRNA Gaussian

268 the lncRNA function similarity (LNCFS), the lncRNA Gaussian interaction profile kernel similarity (L

269 he gradient boosting algorithm to obtain the lncRNA-disease association prediction.

270 We examined the expression of the lncRNA Gas5 in nucleus accumbens (NAc), a key brain rewa

271 mportant, but also that transcription of the lncRNA locus alone can have regulatory functions.

272 gether, our study highlights the role of the lncRNA LUCAT1 as a post-induction feedback regulator whi

273 nuclear and genome-wide localization of the lncRNA Malat1.

274 We demonstrated that a short variant of the lncRNA Trans-acting small interference RNA3 (TAS3) incre

275 ng by the same repressive complexes that the lncRNA recruits to other genes.

276 generalized CARPID to explore binders of the lncRNAs DANCR and MALAT1, revealing the method's wide ap

277 coding transcripts was identified from these lncRNA loci via tandem mass spectrometry, which paved th

278 Thirty-three of these lncRNA hits sensitize cells to radiation, and based on t

279 al rationale for the implementation of these lncRNAs and WDR26 as therapeutic targets for the treatme

280 regulation and mechanism of action of these lncRNAs are in their infancy.

281 Functional analysis of these lncRNAs by several hybrid methods, revealed that salt re

282 C is a ubiquitous oncoprotein, some of these lncRNAs probably play a significant role in cancer.

283 anscriptional repression of any one of these lncRNAs reduces the proliferative capacity of the cells.

284 an Sox2 interacts directly with one of these lncRNAs with high affinity through its HMG DNA-binding d

285 c definition of lncRNA, which excludes those lncRNA gene loci with small open reading frames from bei

286 Thus, lncRNAs can represent powerful RNA machines.

287 150 differentially expressed proximal tubule lncRNAs during fibrosis suggests they may have unanticip

288 elective overexpression of CNRIP1 and of two lncRNA genes (LOC107985892 and LOC102724389) in all affe

289 gth requires an lncRNA (e.g., hTERC) and two lncRNAs in the ribosome that are required for protein sy

290 mour progression, we revealed that these two lncRNAs induce the activation of AKT to promote cancer p

291 This is demonstrated on the uncharacterized lncRNA GATA6-AS1 in dilated cardiomyopathy.

292 o1, pho84 and tgp1 are repressed by upstream lncRNAs and are sensitive to changes in lncRNA 3' proces

293 ate-rich medium by transcription of upstream lncRNAs that interferes with activation of the flanking

294 istic regression models were developed using lncRNAs and/or electronic health records (EHRs) from cli

295 transcribed during phosphate starvation when lncRNA synthesis abates.

296 However, whether lncRNA alterations are passengers acquired during cancer

297 Here, I review two eukaryal systems in which lncRNA interference with mRNA expression underlies a reg

298 The Xist lncRNA mediates X chromosome inactivation (XCI).

299 The Xist lncRNA requires Repeat A, a conserved RNA element locate

300 Yet, lncRNA LINP1 is over-expressed in multiple cancers and c