ライフサイエンスコーパス: local injection

1 nt induction of apoptosis in solid tumors by local injection.

2 transfer of these cells via mini-endoscopic local injection.

3 models for both wet AMD and GBM after single local injections.

4 on in vivo in the mouse joint was studied by local injection and electroporation of siRNA designed to

5 for the potential use of CCL22 delivered by local injection as a strategy to enhance the efficacious

6 Two patients treated with local injections (epidural blood patches and/or epidural

7 5% bupivacaine, or 0.9% sodium chloride as a local injection immediately postoperatively.

8 ) either systemically (10 mg/kg, i.p.) or by local injection in the amygdala (2.5 mug) without affect

9 heroin but not the rate of escalation, while local injection into accumbens shell selectively suppres

10 Doxycycline was administered by local injection into the wound base following injury.

11 omly assigned (1:1) to groups given a single local injection of 120 million Cx601 cells or placebo (c

12 In addition, local injection of 2 x 10(5) latent transforming growth

13 ontralateral motoneuronal EPSPs as well as a local injection of 6-cyano-7-nitroquinoxaline-2,3-dione

14 induction of Treg migration was inhibited by local injection of a CCR4 antagonist, indicating a role

15 e rhythmic vibrissa movements are induced by local injection of a glutamatergic agonist, kainic acid.

16 for endogenously released ACh in vivo by the local injection of a high concentration KCl solution to

17 Peripheral blockade of the activity by local injection of a hydrophilic lidocaine derivative (Q

18 Local injection of a mixture of 1, 2, 3, 4-tetrahydro-6-

19 By means of a single local injection of a set of adeno-associated virus (AAV)

20 Furthermore, local injection of AAV-shRNA-Atp6i/TIRC7 into the period

21 ested for exogenously applied ACh in vivo by local injection of ACh (500 nL, 0.5 M) twice.

22 ation of the Smad2/3 signaling axis, we used local injection of adeno-associated viral vectors (AAVs)

23 ect of hippocampus-specific A2AR deletion by local injection of adeno-associated virus type 5 (AAV5)-

24 Local injection of adeno-associated viruses expressing s

25 Local injection of adiponectin into the POA induced prol

26 which the esophageal mucosa is challenged by local injection of allergen extracts, could identify ind

27 Moreover, local injection of an adenoviral vector encoding LIF sup

28 by using radiofrequency ablation (RFA) with local injection of an immunostimulant, OK-432, resulted

29 examined the role of SRF in ulcer healing by local injection of an SRF expression plasmid into ulcers

30 Importantly, local injection of anti-DC-STAMP-mAb also suppressed alv

31 Local injection of anti-ICAM-1 and anti-ICAM-1/liposomes

32 Similarly, local injection of antiserum against CRF, but not to IL-

33 No adverse events were associated with local injection of any dose of MSCs.

34 Local injection of apyrase, an ATP-hydrolyzing enzyme, i

35 Local injection of ARN077 decreased mechanical hyperalge

36 apid chemotactic response can be mimicked by local injection of ATP and can be inhibited by the ATP-h

37 ogel matrix is spontaneously formed upon the local injection of ATP.

38 igitorum longus muscle was then injured with local injection of BaCl(2).

39 peptide, TNF-alpha was induced centrally by local injection of bacterial lipopolysaccharide (LPS).

40 e gluteus maximus muscle (GM) was injured by local injection of barium chloride solution (1.2%, 75 mu

41 Local injection of BDNF in vivo into a normally negative

42 Cell therapy based on local injection of BM-MSCs or AT-MSCs is effective in de

43 eversed the cardiovascular changes caused by local injection of BMI or the noncompetitive GABA antago

44 ed heterotopic bone formation in response to local injection of BMP2.

45 tudy was conducted to evaluate the effect of local injection of bone marrow-derived mesenchymal strom

46 Sps prior to acupuncture and mimicked by the local injection of capsaicin.

47 Moreover, we report that local injection of CD47nb-expressing bacteria stimulates

48 mechanical probing of hindlimb muscles, and local injection of chemical stimulants (capsaicin and br

49 Therefore, we tested whether local injection of clonogenic CPCs and NF-IGF-1 potentia

50 Local injection of CpG and polyI:C in a primary tumor si

51 n neurons led to disease exacerbation, while local injection of CRAMP1-39 at the peak of EAE promoted

52 ut not postsynaptic APP deletion through the local injection of Cre-expressing adeno-associated virus

53 inase B (TrkB) signaling in the ACC, through local injection of cyclotraxin-B (a novel, highly potent

54 Local injection of DA agonists in the medOB decreased th

55 In addition, we show that local injection of DHEA accelerates impaired healing in

56 Lastly, local injection of dipyridamole, which inhibits transpor

57 Local injection of dominant active MEK produced hyperalg

58 ats treated with CLR dsRNA, documenting that local injection of dsRNA is effective in preventing the

59 esults reported here strongly suggest that a local injection of dsRNA targeting CLR could be an effec

60 A single local injection of encapsulated endostatin-secreting cel

61 re continuously driven out of equilibrium by local injection of energy from their constituent element

62 all be reproduced in experimental animals by local injection of excitotoxic or metabolic toxins into

63 In addition to local injection of fluorescent dye molecules, we demonst

64 Our findings suggest that a single local injection of fluvastatin following tooth extractio

65 l models of MS induce pathology using either local injection of gliotoxins or stimulation of the immu

66 Local injection of glutamate uptake inhibitors or barium

67 d the firing rate of LC neurons in vivo, and local injection of hcrt1 into the LC induced the express

68 ton's nucleus were performed unilaterally by local injection of ibotenic acid (microg/microl, 90 nl)

69 Lesions were performed by local injection of ibotenic acid and chronic activation

70 nerve-selective method for cryoneurolysis by local injection of ice-slurry (- 5 to - 6 degrees C) tha

71 Consistent with in vitro results, a single local injection of IGFBP-5 to the outer periosteum of th

72 The present study tested the effects of local injection of IL-1 and TNF soluble receptors on a p

73 e profile of DCs and pathogenic Th cells, as local injection of IL-1beta following L. amazonensis inf

74 is-like changes in mouse skin induced by the local injection of IL-23.

75 Inhibition of the rmPFC by the local injection of lidocaine produced an increase in the

76 Conversely, local injection of low doses of recombinant LIF diminish

77 Recently, local injection of morphine in the dorsal raphe nucleus

78 allogeneic hindlimb transplants treated with local injection of MSCs exhibited significantly increase

79 Feeding and blood glucose responses to local injection of nanoliter volumes of 5-thio-D-glucose

80 In the humanized SCID mouse, local injection of Netrin-1 into skin enhanced inflammat

81 Systemic or local injection of NF-kappaB decoy ODNs also inhibited c

82 The possible prophylactic effects of local injection of NMDA receptor antagonists that are cu

83 h by systemic nicotine (0.5 mg/kg, s.c.) and local injection of norBNI into the amygdala.

84 Finally, we found that local injection of NPS in the basolateral amygdala promo

85 The VLPO was ablated in 25 rats by bilateral local injection of orexin-saporin, and polysomnography w

86 to L-S-nitrosocysteine were not affected by local injection of oxyhemoglobin or the nitric oxide syn

87 HbAA-BERK mice (the transgenic control), but local injection of PGE(2)-G into the hind paw of HbAA-BE

88 l ulcer healing, we studied whether a single local injection of plasmid cDNA encoding recombinant hum

89 Single local injection of plasmids encoding VEGF165 and Ang1 si

90 became susceptible to experimental BP after local injection of PMN chemoattractant IL-8 or local rec

91 struction of intrinsic striatal neurons by a local injection of quinolinic acid (QA) dramatically enh

92 Combined with aPD-1, local injection of R848-TSLs showed superior efficacy wi

93 Combined with alphaPD-1, local injection of R848-TSLs showed superior efficacy wi

94 Local injection of recombinant C5a induced phosphorylati

95 High-dose systemic administration or local injection of recombinant human EPO has demonstrate

96 tor are highly expressed in the BST and that local injection of recombinant IL-18 (50 ng/ml) signific

97 ced apoptosis in NSCLC cells in vitro, and a local injection of RHO-siRNAs complexed with N-[1-(2,3-d

98 Local injection of riluzole into the LC dose-dependently

99 Local injection of S1P(1) siRNA, but not a negative cont

100 Local injection of sFRP-2 attenuated the beta catenin ac

101 Local injection of steroids, even at sites far from the

102 Accordingly, local injection of the CB1 receptor antagonist rimonaban

103 ruct the onset of focal seizures elicited by local injection of the chemoconvulsant 4-aminopyridine.

104 Local injection of the chemokine stromal cell-derived fa

105 iated macrophages (TAMvarphi) by systemic or local injection of the macrophage-depleting liposomal cl

106 d during vitiligo, which was not possible by local injection of the nontethered anti-IFN-gamma antibo

107 In mice with aggressive lymphoma, a single, local injection of the scaffold following non-curative C

108 nt of hypertension, which was blocked by the local injection of the SP receptor antagonist CP-99994 i

109 er, Phase 2 study tested the hypothesis that local injection of the vasodilator phentolamine mesylate

110 o in a mouse model of paw edema generated by local injection of TNFalpha as well as in mice with CIA.

111 ned in a mouse inflammation model induced by local injection of turpentine to evaluate vascular leaka

112 Local injection of VBL in a low dose into the skin of C5

113 ts that overexpress human alpha-synuclein by local injection of viral-vectors in midbrain.

114 Behaviorally, acute HCN channel blockade by local injection of ZD7288 in the mPFC of SNI rats induce

115 One week later, three weekly local injections of 10-mg SIM in ethanol and contralater

116 Dopamine depletions produced by local injections of 6-hydroxydopamine substantially redu

117 In xenotransplanted human lymphoma, local injections of Bc-NFkBdODN reduced NF-kB activity i

118 Local injections of botulinum toxin type A have been use

119 , activation of accumbens A(2A) receptors by local injections of CGS 21680 increased extracellular GA

120 5 [95% CI, 1.53-5.30], P = .001), and use of local injections of corticosteroids (HR = 2.37 [95% CI,

121 herapy was used in 82.7%, and 34.2% received local injections of corticosteroids.

122 Here we show that local injections of CQ produce mechanical hyperalgesia a

123 ted to surgical EAS myotomy and administered local injections of either a Wnt antagonist (sFRP-2; dai

124 ncer cells in mammary fat pad and treated by local injections of either replication-deficient adenovi

125 in the nucleus accumbens shell (AcbSh) with local injections of GABA agonists or glutamate antagonis

126 Local injections of interferon (IF) alpha have been succ

127 rming previous findings, both peripheral and local injections of m-CPP into the subthalamic nucleus e

128 Local injections of myeloid cell-targeted STAT3 antisens

129 Local injections of norepinephrine suggested that the ch

130 a marked increase in hyperalgesia evoked by local injections of prostaglandin E(2) or epinephrine.

131 Local injections of the acetaminophen metabolite AM 404

132 Local injections of the lipophilic tracer DiI were made

133 Local injections of the neurotoxin SP-saporin into the b

134 tolerated, with increased rates of transient local injection pain and myalgia in the 4CMenB group.

135 Local injection site and systemic reactions (eg, fatigue

136 eceived their first vaccinations to report a local injection site reaction of at least 10.2 cm (4 in)

137 Most AEs were mild local injection site reactions following intradermal vac

138 er than the occurrence of significantly more local injection site reactions in patients treated with

139 d patients should be aware that self-limited local injection site reactions occur more frequently fol

140 Most frequently reported adverse events were local injection site reactions such as injection site sw

141 ut was associated with a higher frequency of local injection site reactions than was the use of needl

142 Local injection site reactions were mild and similar acr

143 n with a multi-agent pre-medication regimen; local injection site reactions were the most commonly se

144 Local injection site reactions, select systemic symptoms

145 gher than expected frequency and severity of local injection site reactions.

146 in modeling the absorption kinetics from the local injection site to the systemic circulation.

147 recipients reporting overall, systemic, and local (injection-site) AEs as well as logarithmic odds r

148 italization, and it was associated with more local injection-site and extrapyramidal adverse effects.

149 Most participants in each group had local injection-site pain and tenderness with treatment

150 More local injection-site pain was noted in the vaccine group

151 Local injection-site reactions among the women were more

152 These results are consistent with local injection-site reactions and other known, generall

153 the subcutaneous group (mainly grade 1 or 2 local injection-site reactions).

154 , on the required large drug dosing volumes, local injection-site reactions, and frequency of injecti

155 d the most frequent adverse events were mild local injection-site reactions, which were reported in a

156 mal MVA85A was associated with expected mild local injection-site reactions.

157 g dosage was more frequently associated with local injection-site symptoms compared with lower dosage

158 Local injection-site symptoms were the most common react

159 Guanfacine was then used in all local injection studies.

160 Through local injection, the membrane anchored GC-PEG-PpIX enabl

161 le receptors to IL-1 and TNF were applied by local injection to sites with induced periodontal destru

162 ounced effect on electromotor recovery while local injection was more effective at increasing fiber c

163 cine heart tissue and mouse breast tumor via local injections were studied and demonstrated.

164 r treatment of USH2A patients using a single local injection which may prevent progression of vision

165 ty concerns require BT to be administered by local injection, which in the case of hyperhidrosis mean

166 igature ( P < 0.05), which was unaffected by local injection with either anti-DC-STAMP-mAb or control

167 We show that local injection with the repurposed phospholipase A(2)-i