ライフサイエンスコーパス: localisation

1 ay be involved in acquiring/maintaining TMC1 localisation.

2 ing pattern consistent with distal appendage localisation.

3 gulates the key interactions and defines B56 localisation.

4 ynthases to ensure their correct subcellular localisation.

5 better than in previous work on haptic sound-localisation.

6 lls, contributing Sdk are sufficient for tAJ localisation.

7 d enhance light-matter interaction via light localisation.

8 ion owing to their sub-optimal intracellular localisation.

9 s with both kinesin-2 and kinesin-1 for this localisation.

10 il region of MKS-5 (Rpgrip1L/Rpgrip1) for TZ localisation.

11 l resource for data on mitochondrial protein localisation.

12 tightly regulated, including at the level of localisation.

13 ermine the configurations' sensitivity field localisation.

14 ified, or the effects of S-acylation on IRAP localisation.

15 -YFP fusion in tobacco confirmed a tonoplast localisation.

16 near its C-terminus that are needed for this localisation.

17 tic" stimulation dramatically improved sound localisation.

18 ay not be associated with the primary tumour localisation.

19 HAO1 protein levels and cellular protein mis-localisation.

20 hat the Mango array does not affect cellular localisation.

21 f the connectors as well as hinting at their localisation.

22 ng negatively regulated hASH1 expression and localisation.

23 l agenda that requires precise intracellular localisations.

24 f the inter-individual variability in source localisations.

25 c islands, despite their remote geographical localisations.

26 m by tagging proteins with distinct cellular localisations.

27 rived (AD) LNCaP cells and prominent nuclear localisation accompanied acquisition of the NE-like morp

28 a new signal-processing approach to improve localisation accuracy and increase generalisability to a

29 We aimed to: (1) improve haptic sound-localisation accuracy using a varied stimulus set and (2

30 logical function of myocyte, to analyze NOS1 localisation, activity, dimerisation, and its relationsh

31 T for prostate cancer biochemical recurrence localisation after radical prostatectomy, whereas Europe

32 mportantly, mechanically induced Yki nuclear localisation also requires nutritionally induced insulin

33 leaf tissue of C. roseus, cell-specific TIAs localisation and accumulation with 10 mum spatial resolu

34 the standard of reference for the presence, localisation and activity of disease against which the d

35 he effects of these ANKH mutants on cellular localisation and associated biochemistry.

36 help clarify how LIS1 promotes the plus-end localisation and cargo transport functions of dynein in

37 on a fixed space-time metric determining the localisation and causal order of events.

38 f the cell biology of the bacterium, viz its localisation and co-ordination with the bacterial cytosk

39 We identify magnon localisation and coalescence processes, whereby localise

40 s these isoforms can have altered stability, localisation and coding potential, deregulation of APA c

41 linical neurology (ie, history, examination, localisation and differential diagnosis) remain key.

42 Using this genetic tool, we determine the localisation and enzymatic specificity of m(5) C sites i

43 ding preoperative diagnostic assessment, the localisation and extent of disease, and possibly the cho

44 e expression, dimer/monomer status, cellular localisation and function of Marchantia polymorpha and P

45 ies in rodents have described the anatomical localisation and function of the nicotinic acetylcholine

46 nteractions of TlpD and their impact on TlpD localisation and function.

47 P-290 and other MKS module components for TZ localisation and functions together with the NPHP module

48 y by scientists to study protein expression, localisation and interactions.

49 Importantly, E-cadherin controls the localisation and levels of Lgl, a basolateral polarity r

50 gests that this novel Staufen-dependent mRNA localisation and local translation pathway may play a ro

51 e neuronal mRNAs are known to control distal localisation and local translation, contributing to dist

52 lato genospecies and characterised by tissue localisation and low spirochaetaemia.

53 We undertook this study to investigate the localisation and magnitude of the presumed tau Positron

54 us biosensors for detection, identification, localisation and manipulation of a wide spectrum of biol

55 We scored the presence, localisation and pattern of imaging characteristics of i

56 Dystonia Coalition, included description of localisation and phenomenology of AM collected by system

57 We further provide a combination of protein localisation and phenotypic evidence in chick, humans, m

58 ely; however, a unified understanding of how localisation and protein activity function together as a

59 n sustaining fibrillation, and thus accurate localisation and quantification of RDs is crucial for un

60 xclude a major role for cytoplasmic flows in localisation and reveal an organisation of the MT cytosk

61 etween NHEJ and HR, incorporating protein co-localisation and RNF138-dependent removal of the Ku/DNA-

62 ects of these variants on normal subcellular localisation and the ability to desensitise receptor sig

63 However, their exact localisation and the cellular signalling pathway(s) they

64 In this study, we investigated the localisation and the mechanism(s) underlying the non-gen

65 In this study, we investigated the localisation and the mechanism(s) underlying the physiol

66 n as regulators of post-transcriptional mRNA localisation and translation.

67 tations in this sequence abolish MAD1 corona localisation and weaken the SAC.

68 ive high-resolution dataset of human protein localisations and deliver a flexible set of protocols fo

69 Here, we characterise the subcellular localisations and expression patterns of these insertion

70 ating the identification of isoform-specific localisations and high-confidence localisation assignmen

71 sses), accompanied by changes in subcellular localisations and substrate specificities.

72 el, which are small but important anatomical localisations and surgical landmarks.

73 Here we review the discovery, localisation, and functional characterisation toolkit av

74 able accuracy for prostate cancer detection, localisation, and Gleason grading.

75 polarity field, highlighted by PIN1 protein localisation, and is modulated by dorsoventral gene acti

76 vered significant differences in subcellular localisation, and nuclear-cytoplasmic shuttling in respo

77 In this Review, we use a localisation approach to examine the anatomy, physiology

78 to monitor nucleosome unwrapping and histone localisation as a function of tension.

79 We reveal a controllable degree of localisation, as characterised by the inverse-participat

80 ha activity, which requires GSK3beta nuclear localisation, as phosphorylation of Drosha at S(300) and

81 m-specific localisations and high-confidence localisation assignment for proteins in suborganellar st

82 dislocation activities and pronounced strain localisation associated with TBs during mechanical loadi

83 Quantification of localisation, away from the Bose glass phase, was obtain

84 at can increase the signal to noise ratio of localisation based microscopy.

85 ethods, in particular, can be susceptible to localisation bias and spurious sources under these condi

86 Any localisation bias caused by the presence of correlated s

87 perceptual biases, and (ii) whether auditory localisation biases can be reduced following training wi

88 Localisation biases decreased (improved) following train

89 sensory uncertainty, we found that auditory localisation biases increased when auditory localisation

90 P5L delayed cell membrane localisation but once recruited into the membrane it inc

91 Auditory cortex is required for sound localisation, but how neural firing in auditory cortex u

92 acy improved, becoming better than for sound-localisation by bilateral hearing-aid users.

93 It was also markedly better than sound-localisation by either unilaterally or bilaterally impla

94 These travelling localisations can be utilised to generate computing circ

95 tive cameras are required to further improve localisation certainty.

96 disorder, where we directly observe quantum localisation.Cold atom quantum simulation has had challe

97 for low-power, ultra-small devices and their localisation could be used as a resource in quantum memo

98 encoded spatial position consistently across localisation cue type.

99 ng the availability of binaural and spectral localisation cues had little impact on ferrets' performa

100 ix-month-olds, like adults, showed a tactile localisation deficit with their feet crossed, indicating

101 Their precise opposite localisations define plasma membrane domains with specif

102 evolution of wavepackets and show that self-localisation effects may be observed due to the curvatur

103 Consequently, genomic excision of this localisation element and perturbation of RAB13 mRNA targ

104 erived RNAseq datasets defined a core 192-nt localisation element underpinning precise mRNA targeting

105 Here we tested (i) whether systematic localisation errors could reflect reliance on prior know

106 er integrates different types of subcellular localisation evidence with protein information from publ

107 racterised signature genes, we performed new localisation experiments on ARMC3, EFCAB6, FAM183A, MYCB

108 Co-localisation experiments with fluorescence labelled dext

109 ice amplitude, while also exhibiting partial localisation for large disorder amplitudes.

110 mplitude, honeycomb lattices show absence of localisation for the same range of disorder strengths an

111 Fluorescence microscopy revealed localisations for TcEpsinR, TcCLC and TcCHC at the poste

112 Tip localisation from P9 onwards coincides with lipoma HMGIC

113 ation is hampered by the absence of adequate localisation, functional characterisation, and receptor

114 ide array of applications, including protein localisation, gene interaction studies and high-throughp

115 The study of protein localisation has greatly benefited from high-throughput

116 Here we characterise macrophage arrival, localisation, heterogeneity, and functions during kidney

117 genetic interaction, interdependent protein localisation (hierarchy), and proteomic studies.

118 stitutes the realisation of disorder-induced localisation in a driven-dissipative system.

119 n in situ observation of charge carrier self-localisation in a hematite device, and demonstrate that

120 tegories like annotation confidence level or localisation in biological compartments.

121 f CB1R from biosynthesis to mature polarised localisation in cultured rat hippocampal neurons.

122 tors and Mediator Complex), punctate nuclear localisation in euchromatic regions and overlap with Pol

123 ing enzyme of glycolysis displayed a nuclear localisation in hESCs and silencing PKM2 did not alter g

124 cellular distribution and protein-protein co-localisation in human skeletal muscle in the basal state

125 ights the complexity and significance of APC localisation in neurons.

126 07 lines, we assessed protein expression and localisation in ovaries, embryos, pupae or adults by sta

127 es highlight the complexity of intercellular localisation in plant specialised metabolism.

128 is the first method for predicting effector localisation in plants and is a valuable tool for priori

129 ta underlining the importance of ciliary PC2 localisation in preventing PKD are limited because PC2 f

130 Finally, IIS also promotes YAP nuclear localisation in response to mechanical cues in mammalian

131 recise spatiotemporal quantification of PAR3 localisation in the Drosophila oocyte, we identify sever

132 Inactivating Akt prevents nuclear Yki localisation in the wing disc, while ectopic activation

133 o being an ideal candidate for investigating localisation in this regime, microcavity polaritons hold

134 ystematic analysis of protein expression and localisation in various cellular and developmental conte

135 types were mirrored by the distinct LinDYRK1 localisations in logarithmic (mainly in flagellar pocket

136 s show a smooth transition, or crossover, to localisation induced by disorder in square and triangula

137 genes was validated by qRT-PCR analysis and localisation investigated using in situ hybridisation.

138 omatosensory cortex, suggesting that tactile localisation involves coding of abstract features of lim

139 ch demonstrates systematic errors of tactile localisation, involving confusions of body parts and bod

140 Strain localisation is further confirmed through high resolutio

141 We propose that TlpD localisation is instructed by metabolic activity and pro

142 with no peripheral exposure and nanoparticle localisation is observed within the brain parenchyma.

143 The importance of IL-1alpha nuclear localisation is poorly understood.

144 , which functions with Staufen in oskar mRNA localisation, is also required for coracle mRNA localisa

145 systematic errors (biases) in their auditory localisation judgments.

146 Robustness arises because Cyclin B1:MAD1 localisation loses dependence on MPS1 kinase after the c

147 ques such as interferometric photo-activated localisation microscopy (iPALM).

148 etion (g-STED) microscopy and photoactivated localisation microscopy (PALM).

149 Single-molecule localisation microscopy (SMLM) allows the localisation o

150 letion (STED) microscopy and Single Molecule Localisation Microscopy (SMLM) enable an increase in ima

151 Single molecule localisation microscopy (SMLM) has become an essential p

152 single molecule level using single molecule localisation microscopy (SMLM).

153 rate the application of this novel method to localisation microscopy and show both an increase in the

154 We present an imaging system for localisation microscopy based on non-destructive readout

155 The fitting precision in localisation microscopy is highly dependent on the signa

156 n two-colour interferometric photo-activated localisation microscopy, we examine the three-dimensiona

157 opy, structured illumination microscopy, and localisation microscopy, which have all produced stunnin

158 the classical limitations of single molecule localisation microscopy.

159 es of the anticancer properties and cellular localisation of a range of ruthenium complexes in eukary

160 ed PKC activity drastically dysregulates the localisation of ADAM17.

161 ults demonstrate a link between pathological localisation of ANKH mutants with different degrees in m

162 C C-terminus, contributing to the peripheral localisation of APC in fibroblasts.

163 utative lipid binding residues abrogated the localisation of ATG16L1 to the PAS and inhibited LC3 lip

164 ative to equivalent-current dipole models in localisation of auditory evoked responses.

165 V were found to antagonise the mitochondrial localisation of Bax, a key hallmark of the intrinsic, mi

166 was no significant relationship between the localisation of calcification and the rotator cuff tear,

167 were performed to further analyse the exact localisation of CD147 and MMP-2 positivity.

168 l images providing identification as well as localisation of chemical compounds in non-homogenous sam

169 insights on membrane reshaping, subcellular localisation of components, host-pathogen interactions,

170 ion of Coracle protein without affecting the localisation of cora mRNA, suggesting that Staufen simil

171 junction (NMJ), where it is required for the localisation of coracle mRNA and protein.

172 E-cadherin in one layer controls the localisation of E-cadherin in the second layer in a laye

173 We detect co-localisation of eBMD GWAS and osteoclast eQTL associatio

174 operatively and CT scans postoperatively for localisation of electrodes.

175 etic source imaging can be used to infer the localisation of epileptic foci and assist in the design

176 resynaptic boutons, we find no nanoscopic co-localisation of evoked presynaptic Ca(2+) entry with the

177 Loss of EXP1 abolished the correct localisation of EXP2, a pore-forming protein required fo

178 agnitude, direction of change and spatial co-localisation of extreme weather events since 1961.

179 le localisation microscopy (SMLM) allows the localisation of fluorophores with a precision of 10-30 n

180 ar location of this process, we examined the localisation of FtsH metalloproteases, some of which are

181 Very little co-localisation of GM atrophy and lesions was seen, and thi

182 Since localisation of immune cells within tumours may reflect

183 analyse information on the geometry and YAP localisation of individual blastomeres of mouse and huma

184 tiple combinations of interlinked levels and localisation of influx and efflux carriers.

185 he modified cysteines on the plasma membrane localisation of IRAP in HEK293T cells, suggesting that S

186 ane core signalling unit and enables spatial localisation of its individual domains.

187 Transcription, protein expression and localisation of KCa3.1 was analysed by reverse transcrip

188 Co-localisation of Kdo-N3 labelling with the cellulose-bind

189 ts mechanistically via regulation of ciliary localisation of key components of its transduction machi

190 egulates Notch signalling by controlling the localisation of Kuzbanian to the apical domain, where No

191 Accurate localisation of mandibular canals in lower jaws is impor

192 nt an experimental signature of the Anderson localisation of microcavity polaritons, and provide a sy

193 nsport, and regulates transport, density and localisation of micronemal vesicles.

194 ure miRs without altering levels or cellular localisation of miR biogenesis proteins.

195 SysCilia), single cell RNA-Seq data, and the localisation of mRNA and proteins in motile ciliated cel

196 on of TSC2 from Rheb and increased in the co-localisation of mTOR and Rheb post exercise in both FED

197 activation may contribute to the genesis and localisation of MYC-Immunoglobulin translocation breakpo

198 Stimulation of macrophages induced nuclear localisation of NFkB and polyadenylation factors, effect

199 lyadenylation factors also prevented nuclear localisation of NFkB.

200 Hyperplexed Localisation of Organelle Proteins by Isotope Tagging (h

201 As a simpler alternative, we here develop Localisation of Organelle Proteins by Isotope Tagging af

202 distribution, cytoplasmic flow patterns and localisation of oskar and naive bicoid mRNAs.

203 The localisation of oskar mRNA to the posterior of the Droso

204 Furthermore, we show that polar localisation of PIN1 generates an auxin flux circuit tha

205 ology and distribution, as well as disturbed localisation of PIN1.

206 n to disrupt dimerization prevents nucleolar localisation of PiSFI3 and attenuates both its interacti

207 Tip bubbles cause localisation of plectonemes within thermodynamically wea

208 ance drop at 528 nm gives evidence of the co-localisation of polyphenols and DPPH. in micelles.

209 Sub-cellular localisation of proteins is an essential post-translatio

210 explicitly the topologically induced spatial localisation of quantum states in our systems.

211 We did not observe co-localisation of RABEP2 and Rab5 in cells, while ectopic

212 urces and compiles data on the abundance and localisation of RNA and proteins in various biological s

213 -FLIM imaging technology can be used to show localisation of S6K1 phosphorylation in living cells and

214 nderstand medieval psychology, including the localisation of sensory and motor functions to the brain

215 ion of CIB1 by itself is sufficient to drive localisation of SK1 to the plasma membrane and enhance t

216 o facilitate agonist-induced plasma membrane localisation of sphingosine kinase 1 (SK1), a location w

217 TGFbeta1 and fibronectin increased the localisation of tensin1 to fibrillar adhesions.

218 mall-angle X-ray scattering data, allows the localisation of the B domain of the Psf1 subunit in the

219 riant is associated with predominant nuclear localisation of the CDKN2A transcript suggesting the fun

220 inases (MAPKK) in live cells and dictate the localisation of the complexes.

221 The mixed Near Eastern-Middle Eastern localisation of the Druze, shown using both modern and a

222 rin cytoskeleton is required to regulate the localisation of the Hippo pathway effector YAP in respon

223 o determine effects of cordycepin on nuclear localisation of the inflammatory transcription factor NF

224 ty cooling can be implemented to improve the localisation of the ion and thus its coupling to the cav

225 present a deep learning system for automatic localisation of the mandibular canals by applying a full

226 The structural motif for the localisation of the mid-gap states is a crystalline-like

227 Furthermore, this study concludes that co-localisation of the Mre11-Rad50-Nbs1 (MRN) complexes, wi

228 ing, which we attribute in part, to improper localisation of the nuclear envelope protein TPR.

229 ation, and one that learns about the spatial localisation of the outcome which is insensitive to deva

230 lP function and is required for sub-cellular localisation of the protein to the cell division site, p

231 phrinB2/EphB4 signalling controls junctional localisation of the tight junction protein CLDN5 and jun

232 sion site, providing evidence of subcellular localisation of these phospholipids within the outer mem

233 g skeletal muscle fibres; however, the exact localisation of these receptors and how they signal to t

234 ore (the sarcoplasmic reticulum), and the co-localisation of these two structures to form dyads withi

235 proteomic methods can now shed light on the localisation of thousands of proteins at once.

236 We show that TZ localisation of TMEM-138 (Tmem138) and CDKL-1 (Cdkl1/Cdk

237 vo quantification of tissue constituents and localisation of tracts potentially affected in alcohol d

238 The pressure created by the localisation of tumour cell proliferation and death gene

239 Our results show the localisation of variants to genes implicated in adsorpti

240 as most closely correlating with the nuclear localisation of YAP.

241 gnalling is a key determinant of the nuclear localisation of YAP/TAZ in basal layer cells and in skin

242 n on the expression patterns and subcellular localisations of many proteins in parallel, we have perf

243 The propagation of localisations on a single actin filament is experimental

244 osynthesis, possibly through the subcellular localisation or activity of lipid kinases.

245 er TMEM-138 or CDKL-1 exhibit interdependent localisation or genetic interactions with core MKS or NP

246 rtile patients), along with total levels and localisation patterns of PLCzeta within the sperm head.

247 The structure, topology, protein-localisation patterns, and dynamics are automatically qu

248 The automatic landmark localisation performance was within the inter-observer v

249 cts of disorder and lattice geometry against localisation phenomena in a weakly interacting ultracold

250 Localisation phenomena in highly disordered metals close

251 We discovered that the localisation phenomena in the disordered Ta layer lead t

252 Here, to shed light on these localisation phenomena, we studied the dc transport and

253 on-ergodicity and purely quantum (many-body) localisation phenomena, which need to be challenged furt

254 al systems, with unique properties for light localisation, photon transportation and energy harvestin

255 h which takes full account of the individual localisation precisions in all three dimensions.

256 ditions, and having accounted for false site localisation probabilities, the number of unique non-can

257 sistant to R1881 treatment and hASH1 nuclear localisation remained evident in apparently dedifferenti

258 ls of influx carriers with the same nonpolar localisation, requires simultaneous modulation of efflux

259 eta, IL-1alpha carries an N-terminal nuclear localisation sequence (NLS) and is trafficked to the nuc

260 bind Yki/YAP as well as a conserved nuclear localisation sequence (NLS) and nuclear export sequence

261 Based on docking of a nuclear localisation sequence, point mutations were designed, wh

262 t binding to transport receptors via nuclear localisation sequences (NLSs) and the effect of size on

263 Deletion of the nuclear localisation signal led to low CHK1 activation and low c

264 s nuclear transport, preventing NLS (nuclear localisation signal)-cargo release from RanGTP-importin

265 In vitro biochemical assays and localisation studies demonstrate that this family of enz

266 alisation, is also required for coracle mRNA localisation, suggesting that similar mechanisms target

267 tivariate decoding in an audiovisual spatial localisation task, we show that the brain accomplishes B

268 rtex (A1) while ferrets performed a relative localisation task.

269 of the cytoplasmic lines (67) show discrete localisations that provide clues on the function of the

270 are required for vacuole morphology and PIN1 localisation, thereby controlling vacuole and auxin-rela

271 ificant CpG loci indicated their predominant localisation to enhancer regions.

272 Determining a protein's sub-cellular localisation to one or more of these compartments can th

273 expression of contractile proteins and their localisation to stress fibres in HASMCs.

274 ities of Bub1 and Mps1 are required for Sgo2 localisation to the centromere region.

275 Mps1 kinase activities are required for Sgo2 localisation to the centromere region.

276 Our results suggest that PC2 localisation to the cilium is necessary to prevent PKD.

277 Importantly, their localisation to the polysome fraction is independent of

278 We observed a significant change in TlpD localisation towards the cell body in cheAY2-, catalase-

279 B13 generated tight spatial coupling of mRNA localisation, translation and protein activity, achievin

280 G389R delayed cell membrane localisation, trended to decrease extracellular inorgani

281 localisation biases increased when auditory localisation uncertainty increased.

282 nd DU145 cells displayed clear nuclear hASH1 localisation under control conditions that was unchanged

283 alysed for their structural conservation and localisation using crystallographic data.

284 nal mechanism of re-entry and focal activity localisation was demonstrated, related to the unexcited

285 gets remained largely unchanged, although AR localisation was genotype- and tissue-dependent.

286 terally implanted CI users showed that sound-localisation was improved when the audio received by beh

287 Co-localisation was observed between RNS-modified tyrosine

288 Subcellular localisation was observed by immunofluorescence microsco

289 unction of rs2421947 genotype, and dynamin-3 localisation was perturbed in murine LRRK2 Gly2019Ser co

290 Without training, haptic sound-localisation was substantially better than in previous w

291 ious studies showing nuclear and cytoplasmic localisation, we observed synaptic enrichment of HDAC11.

292 < 0.05) and right-sided (r = 0.66, p < 0.05) localisation were more challenging to treat.

293 Event-related beamformer localisations were also compared with more traditional s

294 The ANKH mutants dynamic differential localisations were imaged and we investigated the intera

295 t of nsP3 on stress granule responses and co-localisation with GTPase Activating Protein (SH3 domain)

296 urs BFA treatment, TPD52 showed increased co-localisation with LDs, which was disrupted by microtubul

297 ork to operationally define events and their localisation with respect to a quantum clock reference f

298 pecific remorin proteins and differential co-localisation with the cytoskeleton.

299 ning to identify MSCs, their presence and co-localisation with TRAP-positive chondroclasts was noted

300 ined mostly cytoplasmic, forming punctate co-localisations with LC3, increased mineralization, ENPP1