ライフサイエンスコーパス: locally

1 uman health benefits that accrue quickly and locally.

2 s are transported independently and assemble locally.

3 elihood of exceeding 30, 35 and 40 degrees C locally.

4 likelihood that the EOT target has been met locally.

5 ood samples underlines that they are present locally.

6 can be run from our web server or installed locally.

7 to extract acorn protein isolate (API) from locally abundant waste acorn fruit and investigate its e

8 ons at these ultra-relativistic energies are locally accelerated, arise from betatron and Fermi accel

9 eating structural element in peptides is the locally achiral amide group, VCD senses the polymeric st

10 The cumulative incidence of locally acquired malaria was 30.8 per 1000 person-years

11 on track to eliminate, having reporting zero locally-acquired malaria cases in 2017 and 2018.

12 synapses, their ratio is strikingly balanced locally across dendritic segments.

13 Here, we utilized Wnt3a-beads to locally activate Wnt co-receptors.

14 Additionally, PKA is rapidly and locally activated by mechanical stretch in an actomyosin

15 proportion of these cutaneous T cells can be locally activated upon injection of monocyte derived den

16 igation measures should promote abundance of locally adapted and stress tolerant tree species instead

17 hose autochthonous to a specific region, are locally adapted domesticated animals that conserve genet

18 oci, suggesting ptarmigan populations may be locally adapted to the plant community composition, elev

19 delineated in the PET images using the fuzzy locally adaptive Bayesian algorithm, and manually in the

20 n ancestrally plastic phenotype to produce a locally adaptive trait, but the role of plasticity for a

21 nd well-established clinical safety profile, locally administered doxycycline represents a promising

22 de a strategic path forward for developing a locally administered drug delivery system for treating D

23 We investigated the efficacy of locally administered heparin-binding epidermal growth fa

24 In a mouse model, locally administered vesicles provoke significantly more

25 n, is 11.7 months (95%CI 8.6-15.7 m, n = 15, locally advanced (2) and metastatic (13)).

26 inoma (HNSCC), its role in the management of locally advanced (LA) disease is not defined.

27 Ninety-three patients had advanced stage (50 locally advanced and 43 metastatic) and 65 had lower sta

28 checkpoint inhibitor and/or chemotherapy in locally advanced and metastatic urothelial carcinoma.

29 sis of the R/M cSCC cohort from the 2-cohort-locally advanced and R/M-phase II KEYNOTE-629 study.

30 We enrolled patients with locally advanced and/or metastatic anaplastic thyroid ca

31 ry therapy for localized chondrosarcoma; for locally advanced and/or metastatic disease, no known eff

32 ohort of ten patients with biopsy-confirmed, locally advanced breast cancer at the pre-treatment time

33 rapeutic intensification among patients with locally advanced cervical cancer (LACC) and paraaortic l

34 n acceptable safety profile in patients with locally advanced cutaneous squamous cell carcinoma for w

35 Patients with locally advanced cutaneous squamous cell carcinoma have

36 his retrospective study of 184 patients with locally advanced ESCC.

37 imizes staging and survival in patients with locally advanced esophageal adenocarcinoma (EAC) treated

38 chemoradiation and surgery in patients with locally advanced esophageal cancer.

39 Multimodality therapy for patients with locally advanced esophageal carcinoma is recommended.

40 rbed dose and survival and tumor response in locally advanced inoperable hepatocellular carcinoma tre

41 immunotherapy could change the perception of locally advanced lung cancer as a potentially lethal dis

42 gatinib in patients with previously treated, locally advanced or metastatic cholangiocarcinoma with a

43 f first-line pembrolizumab for patients with locally advanced or metastatic cisplatin-ineligible urot

44 ears or older with histologically confirmed, locally advanced or metastatic epithelioid sarcoma; docu

45 d moderate survival duration in unresectable locally advanced or metastatic esthesioneuroblastoma war

46 for stratifying and monitoring patients with locally advanced or metastatic pancreatic ductal adenoca

47 ored the use of entrectinib in patients with locally advanced or metastatic ROS1 fusion-positive NSCL

48 cluded adult patients (aged >=18 years) with locally advanced or metastatic ROS1 fusion-positive NSCL

49 ab-paclitaxel in patients with unresectable, locally advanced or metastatic triple-negative breast ca

50 treated patients aged 18 years or older with locally advanced or metastatic urothelial carcinoma, fro

51 2020 for cisplatin-ineligible patients with locally advanced or metastatic urothelial carcinoma.

52 er with histologically proven, unresectable, locally advanced or metastatic, HER2-positive, PD-L1-uns

53 rolled adult patients (aged >=18 years) with locally advanced or metastatic, MET-amplified, EGFR muta

54 In a specialized setting, P-AR for locally advanced pancreatic adenocarcinoma can be perfor

55 roporation was exceeded in participants with locally advanced pancreatic cancer (17 months) and those

56 Meier method was 17 months from diagnosis of locally advanced pancreatic cancer (95% confidence inter

57 [interquartile range, 56-69 years]; 40 with locally advanced pancreatic cancer and 10 with local rec

58 safety and efficacy of percutaneous IRE for locally advanced pancreatic cancer and locally recurring

59 In the locally advanced pancreatic cancer group, 18 participant

60 Background Patients with locally advanced pancreatic cancer have a dismal prognos

61 nique, may prolong survival of patients with locally advanced pancreatic cancer.

62 nt chemotherapy in borderline-resectable and locally advanced PDAC RESULTS:: In the retrospective coh

63 n a phase II randomized controlled trial for locally advanced PDAC.

64 intermediate-risk or high-risk, localised or locally advanced prostate cancer.

65 treatment option for men with localized and locally advanced prostate cancer.

66 a living organoid biobank from patients with locally advanced rectal cancer (LARC) treated with neoad

67 ently associated with a reduction in pCR for locally advanced rectal cancer after neoadjuvant chemora

68 to concomitant neoadjuvant chemoradiation in locally advanced rectal cancer could increase pathologic

69 zed 5086 patients between 2010 and 2015 with locally advanced rectal cancer who were tested for MSI a

70 tcomes of total neoadjuvant therapy (TNT) on locally advanced rectal cancer.

71 bine improves disease-free survival (DFS) in locally advanced rectal cancer.

72 Perioperative FOLFOX for locally advanced resectable CC is feasible with an accep

73 fety analysis of patients with metastatic or locally advanced solid tumours harbouring oncogenic NTRK

74 er (NSCLC) is terminal in most patients with locally advanced stage disease.

75 py with trastuzumab plus chemotherapy in the locally advanced unresectable or metastatic setting.

76 al in patients with borderline resectable or locally advanced unresectable PDAC receiving SOC neoadju

77 nefit patients with borderline resectable or locally advanced unresectable PDAC.

78 roved disease-free survival in patients with locally advanced UTUC.

79 .06; 95% CI, 1.09-3.91; P = .027) and stage (locally advanced vs resectable or borderline: HR, 1.66;

80 disease: resectable, borderline resectable, locally advanced, and metastatic; patient condition is a

81 e status of 0 or 1, HER2-positive, operable, locally advanced, or inflammatory stage II-IIIC breast c

82 AF(V600E)-mutated, unresectable, metastatic, locally advanced, or recurrent biliary tract cancer, an

83 ve advanced breast cancer with unresectable, locally advanced, recurrent or metastatic disease, Easte

84 ulin may be efficacious for the treatment of locally advanced/MBC for patients with bone, liver, lung

85 In the Phase II locally-advanced trial (NCI# 01821729) cohort of 34 pati

86 (hi) neutrophils, suggesting accumulation of locally aged neutrophils.

87 damycin-resistant strains-may portend a more locally aggressive disease process or may represent pree

88 further subdivided as benign, intermediate (locally aggressive or rarely metastasising), and maligna

89 The stammer, which locally alters the twist of the helix, significantly inc

90 The resulting Ca(2+) elevation is locally amplified by saturation of endogenous Ca(2+) buf

91 , but recent, history of beta bursting, both locally and across basal ganglia networks, impacts on mo

92 diversity for maintaining soil functionality locally and across biomes, as well as providing strong s

93 is important for population management, both locally and across the species range.

94 Here, we examined the consequences of locally and acutely ablating terminal Schwann cells (tSC

95 ept to determine perceptual decision signals locally and for flexible interarea transmission dependin

96 underlying AD, where IL-13 is overexpressed locally and has a significant impact on skin biology, in

97 r, they also orient stress fibers, by acting locally and in parallel to Fat2.

98 el restrictions or quarantine measures, both locally and internationally, would have reduced the numb

99 continuous, undetected circulation of mumps locally and nationally, including multiple independent i

100 chondrial membranes, where it is synthesized locally and plays an important role in mitochondrial bio

101 s, while EMP-derived macrophages proliferate locally and provide a distinct transcriptional response

102 s the benefit of mechanical stimulations for locally and remotely suppressing tumor progression.

103 Rb, (127)I, (133)Cs, and (207)Pb nuclei) and locally and shedding light onto the connectivity, geomet

104 hape by accelerating actin filament assembly locally and slowing filament capping.

105 impaired the secondary T cell response, both locally and systemically.

106 then triggers a GIGYF2-mediated response to locally and temporarily reduce ribosome loading.

107 hase, we found that SARS-CoV-2 spread mostly locally and within state borders.

108 The organic materials were synthesized locally and/or delivered meteoritically on Mars during N

109 are coupled: binding one ATPase opens a gate locally, and also opens the opposite gate allosterically

110 revealed that the number of larvae produced locally, and interaction-induced reductions in growth ra

111 To investigate this, we locally applied arachidonic acid and skin-permeable pero

112 hat healthcare facilities may use to develop locally appropriate programs.

113 e to sinusoidal and arteriolar surfaces, act locally as 'professional cytokine-secreting cells' and t

114 t the flexibility of DNA, which may increase locally as a result of DNA damage, plays an important ro

115 t radiology review and by investigators) and locally assessed prostate-specific antigen (PSA) respons

116 cal microscopy showed that self-lysis occurs locally at even higher frequencies (~94%) at the interfa

117 nd generates omnidirectional ultrasound wave locally at the fiber tip through the optoacoustic effect

118 ility both across megabase-long AgR loci and locally at the recombination signal sequences (RSSs).

119 Arl8B controls axon branching by controlling locally autophagy.

120 All components of the system are made from locally available commodity components, facilitating the

121 mum amount of work within the constraints of locally available energy, water, and nutrients.

122 arks and control (n = 32) that trained using locally available robotic skills curricula.

123 these events, individualized treatment with locally available standard of care should be considered

124 y differentiation, which closely matched the locally available substrate.

125 rly February 2020, which subsequently spread locally before active community surveillance was impleme

126 a model wherein sister cohesion is mediated locally by a single cohesin ring.

127 ts suggest that IRK localization is informed locally by adjacent cell types.

128 s demonstrate that the CSF flow is generated locally by caudally-polarized motile cilia along the ven

129 noic acid, which is synthesized and degraded locally by olfactory cells; (2) old age as well as repea

130 ss the uPBC, this variation is likely driven locally by topographic steering.

131 nkage of related experimental data generated locally by vendor software.

132 (EARL)-compliant and locally clinically preferred reconstructions.

133 d phosphorous as well as a small fraction of locally clustered corner-sharing GeSe(4) tetrahedra.

134 ecies have evolved traits that allow them to locally co-occur.

135 n graphs to identify and extend anchors into locally collinear blocks have potential for scalability,

136 ways to evade immune response guided by the locally common MHC alleles.

137 is involves a transition between diffuse and locally concentrated molecules akin to biophysical phase

138 sensory signaling in motor cortex in rats by locally concentrating and releasing a GABA(A) receptor a

139 espectively, within previously unrecognized, locally confined branching structures.

140 efforts, although critically important, are locally constrained.

141 The cheese sauce was likely locally contaminated, although the mechanism is unclear.

142 and protein phosphatases provides a means to locally control the phosphorylation status and action of

143 The monolithic stationary phases were first locally created in capillaries inserted into the channel

144 Upon release from the carriers, drugs locally cross the intact BBB.

145 d excitons (2.33 eV) that originate from the locally crumpled layered architecture.

146 gests application to a wide variety of other locally crystalline materials.

147 ts show that population-weighted exposure to locally defined extreme heat (i.e., "population heat exp

148 he deviation of neuronal firing rates from a locally defined set-point, independent of global sleep-w

149 nterfaces and sediment heterogeneities could locally degrade groundwater quality, even in aquifers wi

150 w self-generated gradients, created by cells locally degrading attractant, allow single cells to navi

151 conditions, through the Golgi apparatus was locally delayed, almost tenfold, between medial and tran

152 d-targeted microbubble destruction (UTMD) to locally deliver microRNA-loaded nanoparticles to HCC.

153 Locally delivered STING agonists could help to reduce tu

154 In vitro and in vivo analyses confirmed that locally delivered tAPC-reprogramming nanoparticles led t

155 seful approach for assessing the efficacy of locally delivered therapies.

156 Locally delivered ureteral relaxants therefore may impro

157 In RPT, radiation is systemically or locally delivered using pharmaceuticals that either bind

158 around teeth or to identify the efficacy of locally-delivered Scl-Ab for targeted drug delivery.

159 se of systemically-delivered versus low dose locally-delivered Scl-Ab via poly(lactic-co-glycolic) ac

160 ady and likely to be socially acceptable are locally deployable only, whereas those which are scalabl

161 Averaging locally derived Processes S and their rate parameters yi

162 mmunity is described, along with examples of locally derived schemes for the early detection of disea

163 re gas-filled microbubbles (MBs) that can be locally destroyed by using external US.

164 ropped areas at a global scale by leveraging locally determined unexpected variations in rainfall.

165 ence of highly populated, heterogeneous, and locally disordered dimeric intermediates along the dimer

166 that proteins function in the presence of a locally disordered lipid state.

167 tructures show that SOX factors can bind and locally distort DNA at superhelical location 2.

168 We present a novel, to our knowledge, locally distributed tension molecular dynamics (LDT-MD)

169 due to the presence of multiple triggers and locally driven ground responses.

170 or lymphocytes and monocytes, accompanied by locally elevated plasma levels of the T-cell chemoattrac

171 em's breathing circuitry which we confirm by locally eliminating the u-Opioid receptor.

172 lient, thus equitable, coordinated, safe and locally-embedded Arctic research enterprise.

173 We found that heterochromatin repulsion is locally encoded by Set1/COMPASS on certain actively tran

174 tion and local Ge-Ge chain growth as well as locally enhanced bond alignment under high electric fiel

175 Assisted by nanowire-modified electrodes, locally enhanced electric field treatment (LEEFT) reduce

176 accumulation, which leads to clustering and locally enhanced flow.

177 l: light elements including C, N, O, and Na, locally enriched up to 0.1 at%, as well as heavy element

178 orphology and effaced transverse furrows are locally evident, but the predominant morphological featu

179 nt, an epidemiological view postulating that locally evolving environmental V. cholerae contributes t

180 Photoexcitation of the anthracene to a locally excited state (LES) is followed by concerted ele

181 However, these techniques locally expose the brain to high near-infrared light dos

182 re less cold-tolerant were more likely to go locally extinct at colder sites and during colder period

183 n intimate connection with vitrification and locally favored structures inhibiting crystallization.

184 The locally formed tin-copper alloys are electron-conductive

185 ries, whereas single-cell escape depended on locally free tissue space.

186 polycarpic plants, environmental signals are locally gated by the presence of developing fruits initi

187 Locally generated nitric oxide activates the nitric oxid

188 energy through nonradiative decay pathways, locally generating heat that efficiently kills targeted

189 consequently either migrate further North or locally go extinct.

190 line before the first COVID-19 cases emerged locally had larger increases in weekday and weekend TIB

191 rug concentrations, but allows reactivity to locally higher concentrations.

192 rking point of the brain model, coupled with locally hyperexcitable node dynamics of the epileptogeni

193 the different plans and the delivery of four locally important water-related ecosystem services model

194 ociation and bond-formation events occurring locally in chemical reactions on surfaces.

195 Although extreme phenology occurred locally in different years, three nationwide extreme phe

196 IL-13 markedly increased eosinophil numbers locally in lung and airways and distally in blood and BM

197 ed States and that the virus was circulating locally in the country as early as mid-March.

198 manipulation of this endogenous KAR activity locally in the newborn LA perturbed development of gluta

199 The most common ADRs occurred locally in the oral cavity and were categorized as mild.

200 ng experiments, demonstrated that CEPR1 acts locally in the reproductive bolt to control yield and se

201 igen processing and immune activation occurs locally, in the oesophagus.

202 Biofilm-specific antibiotic delivery could locally increase drug concentration to break antimicrobi

203 d-party species and client partner abundance locally increased (creating choice options), whilst part

204 the epidermal growth factor receptor (EGFR), locally increases the abundance of reactive oxygen speci

205 (MD) simulations-we report that cholesterol locally increases the bending rigidity of DOPC membranes

206 p and synapse pruning after antennal injury: locally increasing the need to clear neural debris is as

207 ogically, one of the VTA Sst neuron subtypes locally inhibited neighboring dopamine neurons.

208 lymerization and recruitment of Myo9b, which locally inhibits Rho activity to enhance directional cel

209 troduces the possibility to administer drugs locally into lungs increasing drug accumulation in alveo

210 lamide impaired extinction also when infused locally into the ventromedial prefrontal cortex, basolat

211 and migrate into collagen-rich matrices and locally invade and disseminate in vivo.

212 esection due to intraoperative metastasis or locally irresectable tumor, 2) macroscopically or micros

213 a more condensed configuration in APL cells; locally, it intrudes RNAPII-associated interaction domai

214 When loaded with drugs, the MIPs could locally kill the tumor cells, making them efficient ther

215 xes of freshwater and terrestrial sediment - locally known as red soil pollution - and caused moderat

216 This mechanism locally limits the length of ssDNA sampled for pairing i

217 timulus-dependent linear functions enables a locally linear receptive field interpretation of the neu

218 Thus, locally low MPA density directs local membrane protrusio

219 Here, we apply mechanical loads to locally manipulate the vortices in a PbTiO(3)/SrTiO(3) s

220 canning ion conductance microscopy (SICM) to locally map the ionic properties and charge environment

221 lations suppresses motion signals in MT that locally match the preference of the MSTd cell in both pa

222 Locally measured horizontal advection and entrainment co

223 py, an atomic force microscope modality that locally measures electromechanical surface deformation.

224 smart, and automatic filtering technique for locally minimizing the number of phase residues in noisy

225 eved using a nanopipette injection method to locally mix Cu(2+) salt precursor and benzene-1,3,5-tric

226 patterning as a technique to selectively and locally modulate the carrier density in planar Al-doped

227 atic debt in understory plant communities is locally modulated by canopy buffering.

228 rameters, suggesting that its performance is locally near-optimal.

229 While site-specific PTMs act very locally on the protein, specific protein interactions ty

230 Whether TMR acts locally or globally on cortical sleep oscillations remai

231 developed R848-TSLs that can be administered locally or systematically, resulting in tumor regression

232 calcite surface drives the molecules to form locally ordered arrays, which is conceptually different

233 formation of nanoscale domain boundaries of locally ordered dipoles.

234 derstanding of the mechanisms by which these locally ordered protein aggregates self-assemble in solu

235 While some IBV strains replicate locally, others can disseminate to various organs, inclu

236 The locally preferred clinically reconstructed images were b

237 wound healing model, we report that RvE1 is locally produced in response to intestinal mucosal injur

238 cellular events are tightly coordinated via locally produced regulatory biomolecules.

239 Thus, enhancer properties of locally produced WntD directly impinge on the global mor

240 xcitation of far projecting LVa neurons over locally projecting LVb neurons.

241 hase separate at particular genomic loci and locally promote the biomolecular interactions underlying

242 to electricity, they are designed to utilize locally radiated heat.

243 ining studies did not find interneurons with locally ramifying axons in the LH [11, 12], and nearby s

244 rma's landfall, we found Croton linearis' (a locally rare plant that is the sole host for two endange

245 p new avenues to target metabolic regulators locally rather than globally for healthy aging.

246 ex-wide and spatially organized correlate of locally recorded neuronal activity (Schwalm et al., 2017

247 andomly assigned patients 2:1 with untreated locally recurrent inoperable or metastatic triple-negati

248 E for locally advanced pancreatic cancer and locally recurring pancreatic cancer in a prospective pha

249 scular channels as an important mechanism to locally reduce fluid flow.

250 ngle low-dose injection of the hybrid system locally reduces inflammatory cytokine levels.

251 pothesized that IDO could play a key role to locally regulate cardiac homeostasis after MI.

252 iliary beating and transfer these signals to locally regulate the response of the axoneme.

253 Focal adhesion behavior is locally regulated by stiffness; however, how cells globa

254 These observations establish PKA as a locally regulated effector of cellular mechanotransducti

255 Among the locally regulated genes, we identified the R2R3-MYB tran

256 receptors from the surface of terminals and locally reinserts them to maintain the diffusible surfac

257 hown that protective respiratory reflexes to locally released bacterial bitter "taste" substances are

258 n and restoration initiatives by providing a locally relevant understanding of the causes of mangrove

259 This allows them to locally reprogram the tumor microenvironment and activat

260 expressed by alveolar type 1 (AT1) cells and locally required to specify a subset of ECs.

261 The requisite of additional surgery after locally resected T1 CRC is dependent on the risk of LNM.

262 We present a global, locally resolved life cycle assessment (LCA) model to as

263 of a three-dimensional (3D) nearly-periodic, locally resonant phononic crystal (PnC).

264 rithm to minimize the number of residues and locally restrict the artifacts caused by filtering to th

265 and that long-term memory of these genes is locally restricted by cohesin.

266 ancers globally retaining mitotic H3K4me1 or locally retaining mitotic H3K27ac are associated with ce

267 locomotion in female adult rats showed that locally rewired as well as compensatory NRG fibers were

268 During walking and swimming, both locally rewired as well as compensatory NRG plasticity w

269 Our data demonstrate comprehensively that locally rewired as well as compensatory plasticity of re

270 We demonstrate the causative relevance of locally rewired as well as compensatory reticulospinal p

271 ecovered function, while the contribution of locally rewired NRG plasticity to wading performance was

272 elivers significant in-plane strains and may locally rupture and penetrate the cell.

273 -rich adhesions, defined by their ability to locally secrete proteases and remodel extracellular matr

274 Locally secreted BMP7 can directly promote Treg-cell gen

275 es in China where the domestic combustion of locally sourced bituminous ("smoky") coal has been assoc

276 -bed reactor using both simulated biogas and locally sourced industrial biogas.

277 pports some health interventions among IDPs, locally sourced solutions are lacking.

278 tes changes either the Z(2) invariant or the locally stable valley Chern number.

279 d with stereochemical effects imposed by the locally strained structural context.

280 means-based permitting, the best achievable, locally suitable environmental outcomes (subject to 10%

281 The tolerance state systemically and locally suppresses the development of exacerbated and pa

282 alysis shows that, whereas both peptides act locally, the inhibitor EPF1 exerts longer range effects

283 seed the lung before birth and self-maintain locally throughout adulthood, but are regenerated by bon

284 second sequence uncages the carrier's cargo locally to achieve high target specificity without compr

285 cer-defined stage IIIA NSCLC that was deemed locally to be surgically resectable by a multidisciplina

286 quiring ligand-activated receptors to couple locally to effectors at terminals.

287 ion whereby an ICD inducing drug is injected locally to generate immunogenic apoptotic fragments/cell

288 opO1-1 is required for P. syringae to spread locally to neighboring tissues during infection.

289 one-third of plant transcriptomes responded locally to S. sclerotiorum, including a high proportion

290 l electronic redistribution, are expected to locally tune the intrinsic catalytic activity of carbon

291 state, two minor native-like states, and two locally unfolded states in aqueous solution.

292 iple regions of RNA polymerase, trapping and locally unwinding proximal upstream DNA.

293 ther BaYaka men's testosterone was linked to locally-valued fathering roles, we found that fathers wh

294 The dust particles travel through locally varying fracture apertures with varying speeds a

295 Therefore, if a logical qubit is encoded non-locally, we can-for a limited time-detect and correct no

296 al variation of ACA width was assessed using locally-weighted scatterplot smoothing (LOWESS) regressi

297 ition temperature, the disordered states are locally well-segregated yet the B blocks of ABA amphiphi

298 were low, suggesting that HFOs are generated locally within the LS GABAergic population.

299 While KynA is generated locally within the nervous system, its precursor, kynure

300 hanced PCP-modulated functional connectivity locally within the nucleus accumbens and basal forebrain