ライフサイエンスコーパス: locus

1 A) mutation from the endogenous mouse Card14 locus.

2 used by loop extrusion across the entire Igh locus.

3 [95% CI], 1.53 to 2.44), overlapping the HLA locus.

4 been associated with human leukocyte antigen locus.

5 ed in ~ 95% of 14q deletions involving HIF1A locus.

6 -imbalanced manner to the fSNPs on the FGFR2 locus.

7 minigene from the immunoglobulin heavy-chain locus.

8 07, which was able to identify only the APOE locus.

9 (0.900), mandating the addition of a seventh locus.

10 ssfully map the UBC-GFP transgene to the MHC locus.

11 n the genome and its inheritance as a single locus.

12 ity can be imported into a heterologous gene locus.

13 sor responsible for awn inhibition at the B1 locus.

14 have been reported to contain an intact ETT2 locus.

15 ncy genetic variants located within the FADS locus.

16 inserting tdTomato into the endogenous NPPB locus.

17 to decreased H3K4 methylation in IL-10 gene locus.

18 apped the SCR74 receptor to a 43-kbp G-LecRK locus.

19 er confirming the regulation of WBLM by this locus.

20 to maintain the genetic architecture of the locus.

21 ive and repressed states of chromatin at the locus.

22 d with genetic variants outside of this FADS locus.

23 l activator is integrated into the etv2 gene locus.

24 lular investigation of the modifiers at this locus.

25 ed the tdTomato fluorophore into PpDEK1 gene locus.

26 s, and is important for remethylation of the locus.

27 s known alternative variants at each genetic locus.

28 d 30 InDels were detected at the OsPLDalpha1 locus.

29 by the presence of risk alleles at the Pitx2 locus.

30 ures of the long-sought oncogene interacting locus.

31 e of recombinations in the serotype-specific locus.

32 highlighted by each study, even in the same locus.

33 en individuals carrying variants in the TBX3 locus.

34 o2 allele expressed from the endogenous Ago2 locus.

35 TAT5 signal to mediate plasticity at the Il9 locus.

36 the transcriptional level at the beta-globin locus.

37 ervation that histocompatibility 2, Q region locus 10 (H2-Q10) is a high-affinity ligand for CD8alpha

38 We identified a novel locus (15q24.3) and a known locus (1q32.2) where variant

39 In addition, one novel locus 18q22.2 (P = 2.54 x 10(-9) for the leading SNP rs1

40 entified a novel locus (15q24.3) and a known locus (1q32.2) where variants in or near the gene reache

41 rritory spatially close to its transcription locus(2) and binding diverse proteins(3-5) to achieve X-

42 human leukocyte antigen (HLA) genes at that locus(3-6).

43 We identified a novel locus 3p27.1 that was associated with WBLM (lead SNP rs3

44 ibly acted on a human disease susceptibility locus, a form of balancing selection compatible with typ

45 It maps to the PRC1 locus, a type 2 diabetes susceptibility locus, but its s

46 hat non-neutral processes have acted on this locus across all human populations.

47 hile their decommission is required for TCRA locus activation and enforced alphabeta T lineage differ

48 hma is conferred by alleles within the 17q21 locus affecting ORMDL sphingolipid biosynthesis regulato

49 nvestigate the mechanisms through which this locus affects CHD risk, we measured 35 intracellular met

50 t, but also that transcription of the lncRNA locus alone can have regulatory functions.

51 p to 56.7 kbp length occurred at the capsule locus, along with additional recombination occurring at

52 t GWAS-associated variants within the FAM13A locus alter adipose FAM13A expression, which in turn, re

53 lyses, we observed a genome-wide significant locus among participants with unimpaired cognition on ch

54 n the major histocompatibility complex (MHC) locus, an association that in SLE and Sjogren's syndrome

55 In a combined quantitative trait locus and genome-wide association studies study of apple

56 ning 8) is located in SCZ-associated genetic locus and is aberrantly expressed in patients with SCZ.

57 ucture of the Xi partly depends on the Firre locus and its RNA.

58 ed diagnosis, we strongly implicated the HLA locus and proposed potential non-HLA mechanisms in disea

59 n MHC-II SE contributes to expression of the locus and suggest how variation in these SEs may contrib

60 first time that GQs are present in the DUX4 locus and that the GQ interactive ligand reduces DUX4 ex

61 links between different alleles of a single locus and their associated pathophysiologies.

62 ng that lithospheric thinning influenced the locus and volume of magmatism.

63 t used and best characterized SCN resistance locus, and contains three genes including one encoding a

64 emale-producing temperature, binds the Kdm6b locus, and represses Kdm6b transcription, blocking the m

65 ing from early co-option of dsx as a mimicry locus, and that evolutionary turnover of dsx alleles may

66 describe evidence implicating WT1, the 11p15 locus, and the recently identified genes CTR9, REST and

67 specific disease-associated variants in this locus, and their potential implications.

68 matic pipeline to produce comprehensive sRNA locus annotations of 47 diverse plants, yielding more th

69 Variations in the TLR10/1/6 locus appear to be linked with the risk of contracting a

70 Whereas the risk conferred by the 9p21.3 locus appears to act independently of traditional risk f

71 w that transcription dynamics across the DMD locus are affected by the presence of PTC, hinting at a

72 riations (CNVs) of the human 16p11.2 genetic locus are associated with a range of neurodevelopmental

73 k1)-deiodinase iodothyronine type III (Dio3) locus are up-regulated in an mTORC1-dependent manner.

74 Using the mouse tyrosinase (Tyr) locus as an experimental model, a gene whose mutations a

75 identifies the (P-fimbriae-encoding) papGII locus as the key feature distinguishing invasive UPEC, d

76 vealed a known cannabinoid synthesis pathway locus as well as a series of chemotype-associated genomi

77 ut variations in specific regions of the nod locus, as well as in other plasmid loci, were associated

78 Variants in the LOXL1 locus associate with a dramatic increase in risk of exfo

79 sults identified one genome-wide significant locus associated with each of the two phenotypes.

80 A novel locus at 1p13.2 showed significant association with EF (

81 12RB2, IRF1/SLC22A5, STAT3 and an intergenic locus at 6p21.31.

82 A novel locus at 7q21.3 containing TAC1/ASNS was associated with

83 ominent autoimmune and allergic disease risk locus at chromosome 11q13.5(2-7) contains a distal enhan

84 i associated with CHIP status, including one locus at TET2 that was specific to individuals of Africa

85 As a result, histones at the cat-3 locus become hyperacetylated to promote its transcriptio

86 The histone locus body (HLB) assembles at replication-dependent (RD)

87 The histone locus body (HLB) is an evolutionarily conserved nuclear

88 Mutants in the xusABC locus (BT2063-2065) were defective for xenosiderophore-m

89 PRC1 locus, a type 2 diabetes susceptibility locus, but its specific role in pancreatic beta-cells is

90 Thus, LSD1 is recruited to the Pdcd1 locus by Blimp-1, downregulates PD-1 expression by facil

91 increasing chromatin accessibility of ALKBH5 locus, by reducing H3K9me3 levels and promoting recruitm

92 omplex 2 to epigenetically silence FLOWERING LOCUS C (FLC) during vernalization, is central to plants

93 s, such as FLOWERING LOCUS T (FT), FLOWERING LOCUS C (FLC), AGAMOUS (AG) and APETALA 3 (AP3).

94 However, the mean of mismatches VerEp in locus C (VerEpC) was significantly increased in patients

95 when a plant flowers (focusing on FLOWERING LOCUS C, FRIGIDA, and CONSTANS), highlight some recent s

96 Our data demonstrate that the Foxp3 locus can be epigenetically edited ex vivo to generate s

97 small errors in the localization of a single locus can transform an unknotted trajectory into a highl

98 ith recombinants and nonrecombinants at each locus circulating today.

99 are not fully resolved, they likely involve locus coeruleus (LC) stimulation via the nucleus of the

100 The locus coeruleus (LC), the origin of noradrenergic modula

101 d mimicked by chemogenetic activation of the locus coeruleus (LC), the source of forebrain norepineph

102 nin from the main noradrenergic nucleus, the locus coeruleus (LC).

103 in-sensitive MRI to measure the integrity of locus coeruleus pigmented neurons, and 18F-dihydroxyphen

104 ind that the activation of the noradrenaline-locus coeruleus system (NOR-LC) during strong fear memor

105 This differs from the striatum, locus coeruleus, and spinal cord, where multiple peptida

106 illary area, laterodorsal tegmental nucleus, locus coeruleus, inferior and superior colliculus homolo

107 h the established effects of invasive VNS on locus coeruleus-noradrenaline signaling, and support tha

108 ventral thalamus, posterior tuberculum, and locus coeruleus.

109 knock-in of mScarlet into the daf-2b genomic locus confirmed that DAF-2B is expressed in vivo and is

110 unity systems is the CRISPR array, a genomic locus consisting of short, repeated sequences ('repeats'

111 , here, we provide evidence that the genetic locus containing one such gene, BHLF1, indeed contribute

112 Here we demonstrate that locus contraction is caused by loop extrusion across the

113 rearrangements, presumably owing to lack of locus contraction(2,5).

114 A novel locus contributing to grain width under HNT conditions c

115 Locus control region (LCR) functions define cellular ide

116 and nucleosome occupancy in the beta-globin locus control region and gamma-globin gene.

117 V loci are arbitrarily defined and different locus definitions can lead to different performance depe

118 the Adh-coding gene and its known regulatory locus, delta-1.

119 ructure of the HHV-6A and HHV-6B integration locus, demonstrating the utility of optical mapping for

120 embedded in a multiple transcription factor locus derived from ZIC target genes in the mouse genome.

121 t the MADS-box GLOBOSA2 (GLO2) gene at the S locus determines anther position.

122 lar to what is seen with the adjacent CDKN1A locus, DINO expression is regulated by the histone demet

123 during interphase and subsequently complete locus duplication in mitosis in a process known as 'MiDA

124 CspRecT increases the efficiency of single-locus editing to as high as 50% and improves multiplex e

125 e learning algorithm in the context of multi-locus effects to evaluate the diagnostic performance of

126 ram with a recessive mutation at the ELIMAKI locus (EKI), which causes a mechanically defective respo

127 The locus encoding the transcription factor HNF1A harbors su

128 LC gene into the mouse immunoglobulin kappa locus, ensuring its production by all plasma cells (PCs)

129 a spliced lincRNA generated by the MIR193BHG locus, entirely distinct from the previously described m

130 A dominant male-determining locus (M-locus) establishes the male sex (M/m) in the yellow feve

131 At another locus, expression quantitative trait loci at two overlap

132 encoding the pistil determinant and 16-20 S-locus F-box (SLF) genes collectively encoding the pollen

133 Mutants in the tol-pal locus fail to complete division and form cell chains.

134 rates DNA double strand breaks at the target locus, followed by repair through either the error-prone

135 A refined locus for adRP on Chr17q22 (RP17) was delineated through

136 Recent studies showed global increases in Locus for Enterocyte Effacement (LEE)-negative STEC infe

137 1 was recently nominated as a susceptibility locus for multiple sclerosis (MS).

138 midbrain superior colliculus (SC) are a key locus for several critical functions, including spatial

139 VMHvl) is now well established as a critical locus for the generation of conspecific aggression, its

140 Furthermore, we discovered a non-essential locus for the genetic manipulation of the parasite, allo

141 The VNC is the locus for the reception and integration of sensory infor

142 ect via the interal capsule, as an important locus for the regulation of cocaine-cue memories.

143 369) present in billions of people at a risk locus (GDF5-UQCC1), showing how it impacts mouse knee-sh

144 The human TNF/LT locus genes TNF, LTA, and LTB are expressed in a cell ty

145 We propose here a two-locus genome-wide test for detecting digenic inheritance

146 Analytic tools to produce multi-locus genotypes of hosts based on these SNP markers were

147 o Stirling families as controls (a single XY locus had been previously mapped to LG1 in the latter).

148 Our findings indicate that a chromosome 9 locus harboring tightly linked variants in FTSJ3 and GH1

149 ) but pinpointing the causal genes of a risk locus has been challenging.

150 However, the other locus has not been identified despite over five decades

151 fine two distinct haplotypes at the TMEM106B locus have been implicated in multiple neurodegenerative

152 Fine mapping of this locus identified a number of polymorphic candidate genes

153 taining protein, is located within a PD risk locus identified by genome-wide association studies.

154 The locus identified on chromosome 7 (rs56226325, MAF=0.17)

155 One new locus identified was SLC22A9 that encodes organic anion

156 MAPT (encoding tau) Parkinson's disease risk locus, identifying putative ectopic regulatory interacti

157 olygenic risk for PTSD symptoms, and a novel locus implicated in synaptic transmission and plasticity

158 by imprinting disorders (IDs) displays multi-locus imprinting disturbances (MLID), which may result f

159 interspaced short palindromic repeats) array locus in a C. coli isolate.

160 lation (H3K27me3) were observed at the Avr1b locus in a naturally occurring Avr1b-silenced strain but

161 rent versus never in European Americans, one locus in African Americans, and one in Hispanic American

162 other departures from neutrality across the locus in both coding and noncoding regions.

163 art failure sub-phenotyping shows that a new locus in chromosome 1 is associated with left ventricula

164 175/GAK/DGKQ locus is the 3rd strongest risk locus in genome-wide association studies of Parkinson di

165 We identified a genome-wide significant locus in IRAK3 (p = 3.57 x 10(-8), rs11465988, beta = -

166 esults reveal an essential role for the Tug1 locus in male fertility and uncover evidence for distinc

167 ately 3.1 Mb of the S(2) -haplotype of the S-locus in Petunia inflata using bacterial artificial chro

168 distinct pattern of association at the SNCA locus in RBD as compared to PD, with an opposite directi

169 onal epigenetic signatures, and identifies a locus in the proximity of the gene encoding tyrosine kin

170 pplying this method to the alpha-globin gene locus in two different cell types, we predict the 3D org

171 ion, but also the immunoglobulin heavy chain locus, including the IGHV4-61 gene segment, on chromosom

172 e for eight distinct associations at the CRP locus, including two variants that have not been identif

173 letion of a regulatory element in the HOTAIR locus increases glioma cell sensitivity to TMZ and alter

174 ilar distribution patterns within the BdFTL1 locus, indicating their interplay in regulating target g

175 e to complete MiDAS at FRAXA leads to severe locus instability and missegregation in mitosis.

176 with ZNF274 binding at the maternal SNORD116 locus is a potential therapeutic strategy for PWS.

177 d evidence that genetic variation at the ABO locus is associated with both lipid levels and BC.

178 the binding of multiple factors at any given locus is coordinated has been technically challenging to

179 ides in the telomere region, the integration locus is poorly defined due to the low sequence complexi

180 egulated in eki, indicating that the ELIMAKI locus is required to integrate the weight-growth feedbac

181 a modified Y haplotype (Yh) and that the sex locus is small, but it has not previously been precisely

182 The TMEM175/GAK/DGKQ locus is the 3rd strongest risk locus in genome-wide ass

183 Accordingly, the vls locus is the most evolutionarily diverse genetic element

184 The Rhg1 locus is the most used and best characterized SCN resist

185 in the virus infectivity controller 1 (vic1) locus, is responsible for production of antiretrovirus A

186 Notably, the RUNX1 locus itself is also directly activated by E2A-PBX1, ind

187 at reversible DNA inversions within this R-M locus leads to the generation of eight specificity prote

188 in elucidating gene regulation at the single-locus level.

189 Microperimetry locus-level changes between baseline and month 6 were co

190 in chromatin at AgR loci are regulated in a locus-, lineage-, and stage-specific manner during B lym

191 We also discovered the locus-locus interaction of DNAm levels of the CDH6 gene

192 A dominant male-determining locus (M-locus) establishes the male sex (M/m) in the ye

193 bility that noncoding mutations in the ATXN1 locus may act as risk factors for yet to be discovered p

194 A total of 14 distinct locus-metabolite associations were identified in the dis

195 chromatin at the major translocation cluster locus might facilitate the t(11;14)(q13;32), which modif

196 ved an unrelated donor (fully matched or one-locus mismatched at HLA-A, HLA-B, HLA-C, or DRB1 loci) g

197 ed DNA methylation (DNAm) quantitative trait locus (mQTL) studies to predict PAIs.

198 tperformed the alternative scheme, the adh-1 locus must be retired from the PubMLST scheme if it is t

199 By constructing cells in which the Opa1 locus no longer produces transcripts with S2 cleavage si

200 to interactions of attention allocation and locus of control.

201 of virulence genes, notably those within the locus of enterocyte effacement (LEE).

202 helterin mutant engineered at the endogenous locus of human stem cells with an altered telomere lengt

203 cialization, organizational rigidity and the locus of innovation.

204 porters are not reliable proxies for another locus of interest.

205 ate peroxidase (APEX) gene to the endogenous locus of lysosome-associated membrane protein 1 (LAMP1).

206 ave been suggested to be the neurobiological locus of memory improvements into adolescence.

207 activated cyclic nucleotide-gated channel 4) locus of the mouse genome.

208 HDL-C raising genetic variants in the gene locus of the target of CETP inhibitors were associated w

209 al expectation enhances performance, but the locus of this effect remains debated.

210 and the impact of genetic variation within a locus of three FADS genes (FADS1, FADS2, and FADS3) on a

211 nitiate piRNA production from a second piRNA locus on chromosome 10, as well as pi6 itself.

212 We previously identified a disease locus on chromosome 16p12.1-q12.2 with genome-wide signi

213 This dominant trait is conferred by the SSt1 locus on chromosome 3B.

214 iRNAs from a conserved mouse pachytene piRNA locus on chromosome 6 (pi6) produce sperm with defects i

215 y enrichment at the major histocompatibility locus on chromosome 6, consistent with admixture-enabled

216 ositional mapping revealed a single critical locus on chromosome 7.

217 udy (GWAS) identified one novel genomic risk locus on chromosome 8 (lead SNP rs17052966, p = 4.53 x 1

218 The locus on chromosome B1, common to both analyses, reveale

219 approach based on conditional analysis of a locus on multiple traits, overcoming the above and other

220 usly been associated with neuroticism, and a locus overlapping the BDNF receptor gene, NTRK2.

221 gin DNA methylation including the H19/MIR675 locus (paternally imprinted).

222 ogical expansion of the TNR within the FRAXA locus perturbs DNA replication and is the major causativ

223 show that the paternal allele of the Cdkn1c locus plays a key role in maintenance of NPCs during neo

224 tudy of natural allelic variation of the ENO locus proved that a cis-regulatory mutation in the promo

225 Although quantitative trait locus (QTL) associations have been identified for many m

226 hb1 is the most important quantitative trait locus (QTL) for FHB resistance.

227 SA for 3 yr and conducted quantitative trait locus (QTL) mapping for rust progression.

228 ntified a high-confidence Quantitative Trait Locus (QTL) with a single variant of MMS21 associated wi

229 d sex-specific expression quantitative trait locus regulatory networks.

230 mpatible Petunia axillaris, but not in the S-locus remnants of self-compatible potato (Solanum tubero

231 Poor locus resolution and high genetic complexity impede vari

232 Genetic ablation of the Cdkn2a locus restored muscle stem cell properties in lamin A/C-

233 andidate pacemaker-specific REs in the SHOX2 locus resulted in selective loss of Shox2 expression fro

234 al characterization and fine-mapping of that locus reveal a putative causal variant in a cardiac musc

235 ded templates into the T cell receptor (TCR)-locus revealed gene constructs that enhanced fitness in

236 Comparative analyses of S-locus sequences of these three S-haplotypes revealed pot

237 The locus shows several footprints of balancing selection ar

238 rafts and their control in survival rate and locus specific DNA alteration.

239 nstead, TET-mediated active demethylation is locus-specific and necessary for activating a subset of

240 ontact probabilities with respect to bin- or locus-specific biases accounts for previously characteri

241 ear condensates, the components that produce locus-specific condensates, elements of specificity, and

242 ation studies to investigate As exposure and locus-specific DNA methylation using the Illumina Methyl

243 ow a given DNA sequence encodes a particular locus-specific folding pattern remains unknown.

244 Using both locus-specific genetic editing and simultaneous epigenet

245 Locus-specific interrogation of target genes employing f

246 In particular, we find locus-specific temporal changes in accessibility both ac

247 mediated genome organization within the TAL1 locus, suggesting that CTCF boundary plays a pathogenic

248 nce between the morphs is controlled by an S-locus "supergene" consisting of several distinct genes t

249 TERMINAL FLOWER 1 (TFL1) and FLOWERING LOCUS T (FT) and their orthologs antagonistically regula

250 through deletion of a homologue of FLOWERING LOCUS T (FT)), and are associated with seed size, flower

251 f flowering-related genes, such as FLOWERING LOCUS T (FT), FLOWERING LOCUS C (FLC), AGAMOUS (AG) and

252 wise increase in the expression of FLOWERING LOCUS T1 (FT1), which initiates under day-neutral condit

253 cificity gene combinations at the expression locus than bacteria isolated from the mammalian gut.

254 M SKIN 1 (qFIS1), a major quantitative trait locus that partially determines the difference in compre

255 irc-MDM2 identify a new player from the MDM2 locus that suppresses p53 levels and cell cycle progress

256 sible chromatin conformation within the IRF8 locus that was accompanied by a significant increase in

257 fied a 2.9-kb regulatory element at the Isl1 locus that was active specifically in the cardiac inflow

258 = 9.7 x 10-9; CDH10, P = 1.2 x 10-8) and one locus that was significantly associated with the metabol

259 G methylation and silencing of the Dlk1-Dio3 locus, thereby increasing miRNA transcription.

260 k-altering haplotypes overlapping the 648 kb locus (three protective, and four risk (peak odds ratios

261 nce for distinct molecular modes in the Tug1 locus, thus highlighting the complexity present at lncRN

262 st, we no longer rely on proximity to link a locus to a gene which has shown to be unreliable; second

263 the localization of the melanoma regulatory locus to a single gene, rab3d, which shows all expected

264 rliest factor binding and remodeling the Il9 locus to allow BATF binding in both mouse and human Th9

265 delete ZNF274 binding sites at the SNORD116 locus to determine whether activation of the maternal co

266 S variants identified at the clusterin (CLU) locus to identify a subset of likely causal variants, an

267 e performed an in-depth analysis of the SNCA locus to identify RBD-specific risk variants.

268 in a spontaneous 150-kb deletion in the Ddr2 locus to produce an effective null.

269 Hence, SNr is an ideal locus to study pathway interactions and cannabinergic mo

270 CD8 T cells failed to remethylate the Pdcd1 locus to the levels of wild-type cells.

271 To identify genomic locus underlying WBLM, we performed a genome-wide associ

272 ring a point 6955C->T mutation in the Notch2 locus upstream of the PEST domain, and we termed this mo

273 e allele of the strongest AMD-associated CFH locus variant rs10922109 has the highest association wit

274 with PLT/MPV with protein quantitative trait locus variants associated with plasma proteins followed

275 that I/LnJ mice carry an additional genetic locus, virus infectivity controller 2 (vic2), that abrog

276 nal genes and a retinal enhancer RNA at this locus was assessed by qPCR.

277 Genetic variation at the LRRK2 locus was associated with survival in PSP.

278 among 585 F2 plants segregating for the Ptr1 locus was discovered that narrowed the Ptr1 candidates t

279 Finally, the Hexb locus was employed for tamoxifen-inducible Cre-mediated

280 However, a significant common variant locus was identified at 6p21.32 (rs35406322) (P=3.29x10(

281 The AR locus was interrogated for resistance-causing genomic mo

282 The third locus was located in the LINC01572 gene in chromosome 16

283 The strongest eQTM locus was observed for the proopiomelanocortin (POMC; rh

284 ohol interaction on triglycerides in a novel locus was significantly discovered (P=6.65x10(-6) for th

285 ading to loss of heterozygosity at the DGCR8 locus, was found in all 13 samples harboring c.1552G>A;p

286 mosquito, Aedes aegypti Nix, a gene in the M-locus, was shown to be a male-determining factor (M fact

287 g bioinformatic analysis of the genomic DUX4 locus, we have identified a number of putative G-quadrup

288 Approximately 80% of the alleles at this locus were modified, with no evidence of off-target edit

289 intact ETT2 together with an associated eip locus which encodes putative secreted ETT2 effectors as

290 oduced on the paternal chromosome at the EYS locus, which carries a frameshift mutation causing blind

291 presence of an nprl3-linked multiglobin gene locus, which contains a remote enhancer that drives glob

292 n Petunia is controlled by the polymorphic S-locus, which contains S-RNase encoding the pistil determ

293 localise in each chromosome at only a single locus, which corresponds with previously mapped DNA repl

294 for the association in the TMEM175/GAK/DGKQ locus, which could be mediated by affecting GCase activi

295 ism integrating nascent mRNAs at the histone locus, which facilitates phase separation, and the nucle

296 Importantly, deletions of the PTEN locus, which promotes active PI3K signaling, were among

297 ogically associated domain (TAD) at the FLT3 locus, which results in higher expression of FLT3, an im

298 n the underlying genetic architecture of the locus, which will be generally unknown.

299 m capsular polysaccharide (cps) biosynthetic locus, with different mutations arising independently in

300 ic segment within the intact dystrophin gene locus, with the ultimate goal to elucidate dystrophin pr