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1  applied SD to the set of recently generated long accurate Pacific Biosciences HiFi reads.
2 is an investigational principal component of long-acting antiretroviral therapy.
3 torage for global health and developed world long-acting drug delivery applications.
4 isk for HIV, were randomly assigned (3:1) to long-acting injectable cabotegravir (800 mg given three
5 contraceptive services, including short- and long-acting methods, are available, even in protracted c
6 c parameters of TLZ in humans, we designed a long-acting PEG~TLZ for humans that may be superior in e
7 h suppression of lung-specific Th2 responses long after initial treatment.
8 oving cardiovascular regulation and immunity long after SCI.SIGNIFICANCE STATEMENT Spinal cord injury
9  the persistence of germinal center activity long after the period of active viral replication in per
10 les and how disequilibrium compounds persist long after treatment changes have been made.
11                                          Not long ago, the occurrence of quantum mechanical tunneling
12    Each patch of the SU is 50-200 m wide and long and consists of 5-10 m of south-dipping layers.
13 taceous epoch of Madagascar that possesses a long and deep rostrum, an expression of beak morphology
14  Supramolecular fibers in water, micrometers long and several nanometers in width, are among the most
15                                 Due to their long and unique life cycles, these arthropods likely evo
16 ets-each sheet up to hundreds of micrometres long and wide but only about four nanometres thick-in wh
17                                         Both long- and short-DUP patients experienced similar decline
18 ctly measured, and (iv) how g(m) responds to long- and short-term changes in growth and measurement e
19  individuals have flowers with short styles, long anthers, and large pollen grains.
20 ariable regions, such as poly-reactivity and long antigen-binding loops, which are usually under nega
21 ing but functional elements e.g. small RNAs, long antisense RNAs or untranslated regions (UTRs) of mR
22           High arabinose level suggests that long arabinan side-chains maintain cell wall flexibility
23 ld charge separated states with lifetimes as long as 61 microseconds, thereby mimicking the functions
24  be applied to samples from any organism, as long as a sufficient amount of starting material can be
25  and is estimated to have persisted twice as long as the predicted survival time for selectively neut
26          Action potentials propagate through long axons to their postsynaptic partners, which require
27              The curse of dimensionality has long been a hurdle in the analysis of complex data in ar
28                          Meaning in life has long been a mystery of human existence.
29 ting of 1-2% mass of the whole pancreas, has long been believed to be regulated independently from th
30     Increased fatty acid oxidation (FAO) has long been considered a culprit in the development of obe
31                             Dielectrics have long been considered as unsuitable for pure electrical s
32    Inhibition of phospholipase A2 (PLA2) has long been considered for treating various diseases assoc
33 e environmental conditions in the ocean have long been considered relatively more stable through time
34                         Alkoxy radicals have long been known to enable remote C-H functionalization v
35       A visual cortical prosthesis (VCP) has long been proposed as a strategy for restoring useful vi
36                      Mast cells have existed long before the development of adaptive immunity, althou
37 ins evolved in ancient marine microorganisms long before the evolution of land plants.
38 wheat is to manually perform many steps in a long bioinformatics pipeline.
39 cer, these patients require specialised life-long care, with implications for their families.
40 exhibiting a narrow bandgap of 1.27 eV and a long carrier lifetime of 657.7 ns.
41  complex with AR3X, a bNAb with an unusually long CDRH2 that was isolated from the chronically-infect
42 ticular waxes was mainly observed in primary long chain alcohols and, to a minor extent, in long-chai
43 pon exposure to elevated concentrations of a long-chain AC, plausibly caused by its insertion.
44 oxide correlated with early induction of the long-chain acyl-CoA synthetase 1 (ACSL1).
45                                  A series of long-chain acylcarnitines were identified and detected w
46 nal catalytic activities of SIRT6, including long-chain deacylation and mono-ADP-ribosylation of othe
47 the treatment can simultaneously remove both long-chain insulating surface ligands of oleic acid and
48                                              Long-chain n-3 PUFAs (n-3 LCPUFAs) accrete in the brain
49 and varied less (<0.5 log units) compared to long-chain PFASs (>0.5 to 1.5 log units) and zwitterions
50 cerol (MMDAG), mycolate wax ester (MWE), and long-chain triacylglycerols (LC-TAGs).
51        We conclude that while conjugation of long-chain Vi generates T-dependent antigens, the conjug
52 ng chain alcohols and, to a minor extent, in long-chain wax esters.
53                                       Single long covered stents or overlapping covered stents were u
54                    The EACBE is required for long-distance regulation of the Ealpha on the proximal V
55          It highlights a thus-far unexplored long-distance signaling phenomenon that may regulate soi
56                   Migrating sanderlings defy long distances but may end up in winter areas with poor
57 lity to communicate quantum information over long distances is of central importance in quantum scien
58 nd significant power can be transmitted over long distances through corrosion-free, lightweight fiber
59 ation of hunting, tree chopping, and walking long distances, but not tool manufacture.
60 ion (RSE) is characterized by the capture of long DNA fragments (15-20 kb) by magnetic beads, after e
61 e of affect processing to human behavior has long driven researchers to pursue its measurement.
62 C), short duplicates (Co, Cd, 85 degrees C), long duplicates (Co, Pb, 85 degrees C), and insertions (
63            The bunched structure of the very long electron beam produced spectral lines that were obs
64                                              Long Evans male rats received a controlled cortical impa
65  of the actions of great people, acquired by long experience in contemporary affairs, and a continual
66 s the key urban form determinants of decadal-long fine particulate matter (PM(2.5)) trends in all 626
67 y patency and F-MALE and therefore close and long follow-up is advisable.
68 at the cleavage site in this 1192-amino-acid-long fragment is located between amino acids 961-971.
69 e, thus correlating with the accumulation of long G-overhangs.
70                             Soil mixing over long (&gt;10(2) y) timescales enhances nutrient fluxes that
71 modeling studies have begun to question this long-held belief.
72 med an oedematous intestinal loop in a 70-mm-long hernial sac, with no circulation detected.
73 ow interception and characterization of this long hypothesized intermediate.
74            However, the requirement for life-long immunosuppression and its associated side effects p
75 ed pancreas tissue and (b) the need for life-long immunosuppression.
76  mortality estimates from patients with very long intervals until antibiotics with patients with shor
77                                 In a 24.5 mm long juvenile the adult electric organ (EO) was not yet
78  provide a causal, mechanistic account for a long-known visual illusion.
79 ular mediators of these effects, focusing on long-lasting epigenetic changes.
80                                              Long-lasting insecticidal nets (LLINs) are believed to h
81 es fast actions, supra-linear responses, and long-lasting molecular switches.
82                                              Long-lasting, consolidated memories require not only pos
83 he other half of socially defeated rats show long-latencies to defeat (LL/resilient) and are similar
84 fferents induced short-latency (SAI) but not long-latency (LAI) afferent inhibition of face M1, while
85 e phosphorescence material with simultaneous long lifetime and high phosphorescence quantum efficienc
86 ophysical properties with a high fraction of long-lived charge carriers and the availability of a red
87 mation of the electron gas, and periodic and long-lived electron cyclotron oscillations inside the ma
88 imated, including the lifespans of short and long-lived infected cells, and the time to reach viral s
89 stabilized at low levels during the aging of long-lived NMRs and bats.
90 netic perspective on migratory strategy of a long-lived pelagic seabird: Timings and destinations cha
91 limiting the generation of memory B cell and long-lived plasma cell responses.
92 ss by which antigen drives the generation of long-lived plasma cells and memory B cells and highlight
93 arkedly increased proteasomal degradation of long-lived proteins (the bulk of cell proteins) without
94           Strontium-90 ((90)Sr) is the major long-lived radionuclide derived from the Chernobyl accid
95                                          The long non-coding RNA NEAT1 serves as a scaffold for the a
96 pattern was negatively controlled by a novel long noncoding RNA (lncRNA) that we named Stem Cell Inhi
97 earing complementary strands into micrometer-long one-dimensional arrays.
98                                              Long pentraxin 3 (PTX3) is an essential component of hum
99 es in stream water have been changing over a long period.
100 display a delayed phase under short, but not long, photoperiod conditions.
101 ieno[3,2-c]pyridine-4,6(5H,7H)-dione), has a long plasma half-life (~ 24 hours) in mice, suggesting p
102                Wild-type mesoderm cells have long polarized filopodia-like protrusions, which are abs
103 to arrhythmogenic phenotypes associated with long-QT syndrome.
104 ivided into short- (length < quartile 1) and long-range (length > quartile 3) connections, based on t
105 chemoattractant and killing agents result in long-range chemotactic attraction, trapping, and destruc
106 ubiquitously active in human tissues, showed long-range chromatin interactions and mRNA abundance ass
107 connecting tract and averaged for short- and long-range connections separately.
108 S reduces chromatin accessibility and blocks long-range interaction between the +51 erythroid enhance
109 ong short-term memory (BLSTM) to capture the long-range interaction patterns between k-mers amino aci
110                        However, establishing long-range interactions between multiple dopants or defe
111  spin degree of freedom and interact through long-range interactions tunable by changing the cavity p
112                               To capture the long-range interactions, most studies integrate bidirect
113  in chromatin biology is the extent to which long-range looping interactions change across developmen
114  the electric double layer, which blocks the long-range migration of Cu(+) and produces a drastic red
115 pproach to address this challenge, combining long-range PCR and nanopore sequencing with a novel bioi
116 mined, for the first time, mechanisms of the long-range traffic of DAT in intact brain and acute brai
117  in yeast and plants, myosin/actin can drive long-range transport.
118                                    Achieving long-range uniformity remains a challenge, but this proc
119 s, but its description is complicated by the long-ranged nature of dipolar interactions.
120 sition of the hydrothermal fluids suggests a long reaction path involving both mafic and ultramafic l
121 ing using chemical modifications with direct long-read RNA sequencing and machine learning to detect
122                                     Although long-read sequencing improves this issue, it is not amen
123                           Recent advances in long-read sequencing solve inaccuracies in alternative t
124                                        Using long-read sequencing technologies, we provide a high-qua
125  genomic region and, using third generation, long-read sequencing, we identified a 120 kb insertion i
126 cancer-related genes detectable only through long-read sequencing.
127 nscriptome of C. elegans Taking advantage of long reads spanning the full length of mRNA transcripts,
128  survey data for international migrants, the long recall period for occupational and mental health ri
129  pharmacological approach to mild asthma has long relied on reliever therapy with as-needed short-act
130  This has implications for the design of new long-residence-time TSPO ligands.
131 oth the rates of ecological interactions and long-run dynamics of interacting populations.
132                                          For long-running jobs or large memory needs we provide detai
133 enough staff for quality with between 60-80% long shifts was 15% lower (95% confidence interval 2% to
134 confidence interval 2% to 27%) than with all long shifts.
135  bidirectional recurrent neural network with long short-term memory (BLSTM) to capture the long-range
136                                          One long-sought after nanotechnology is systems able to achi
137 ough cell growth in G(1) provides one of the long-sought molecular mechanisms that promotes cell size
138                                   There is a long-standing debate about whether categories are repres
139 nd recovered language performance has been a long-standing goal for cognitive and clinical neuroscien
140 indings and the laying hen model support the long-standing incessant ovulation hypothesis and cortica
141                         Our findings solve a long-standing problem, providing a new insight into the
142 ilar but non-native metal substitutions is a long-standing puzzle.
143                                      Despite long-standing recognition of the importance of precipita
144  results provide an approach that breaks the long-standing trade-off between low energy consumption a
145  While l-morph individuals form flowers with long styles, short anthers, and small pollen grains, S-m
146 evelop a model that identifies patients with long survival.
147 rithm to image a fault zone hosting a 4-year-long swarm in southern California.
148 MTCH2x were localized to mitochondria with a long t (1/2) (>36 h).
149               The genus Saimiri is a decades-long taxonomic and phylogenetic puzzle to which cytogene
150 most TBIs are mild, even mild TBI can induce long term effects, including cognitive and memory defici
151     Neonatal morbidities are associated with long term neurological deficits in life and have also be
152 ine receptor-ligand subsets persisted in the long term.
153 ssigned to the short-term (8 to 10 weeks) or long-term (18 to 20 weeks) healing group.
154                      However, the effects of long-term active restoration of extremely degraded grass
155 ies (SNFs; 113, 40%), and less frequently to long-term acute care hospitals (LTACHs; 29, 10%).
156                                          The long-term adjustment of thylakoid membrane grana diamete
157 ass biomarker amino sugars and SOC, from two long-term agricultural field studies conducted by large
158 nts with T1MI, patients with T2MI had higher long-term all-cause mortality after adjustment for age a
159  low risk of bleeding complications, in whom long-term anticoagulant treatment is likely safe.
160 id autopsy program of individuals undergoing long-term ART.
161 se same loci were enriched for signatures of long-term balancing selection in the native ranges, with
162 ently powered to address whether MAR confers long-term benefit over SAR in patients with renal dysfun
163 creased adipogenesis in some patients during long-term carbamazepine treatment.
164 ncluding acute and critical care management, long-term care and rehabilitation.
165 ng of these risks could meaningfully improve long-term care of patients with DLBCL.
166                         The risk factors for long-term carriage were travelling to Asia, swimming in
167 olyfunctional CD8(+) and CD4(+)T(M) subsets; long-term CD8(+)T(M) maintenance is associated with a pr
168 ed increase in food insecurity on short- and long-term chronic health outcomes, and to delineate the
169 y health status changes were associated with long-term clinical outcomes in the COAPT population.
170                                              Long-term clinical studies are necessary to reach final
171                                              Long-term cognitive decline is an adverse outcome after
172 ure and immunological graft rejection remain long-term complications leading to late graft failure in
173 ts a challenge for estimating representative long-term concentrations.
174 e as environmental conditions change and the long-term continued survival of right whales remains unc
175 as considered that FP/FM could be useful for long-term control of pediatric asthma.
176                  This platform could support long-term culture of intestinal organoids, potentially r
177                                          Our long-term daily insect biomass dataset shows no long-ter
178                                        These long-term data support the use of bictegravir, emtricita
179                            Here, using three long-term datasets on bird reproduction, daily insect av
180 transplantation is often lifesaving, but the long-term deleterious effects of combinatorial immunosup
181 nsity-dependent population models built from long-term demographic data, theoretical models, and meth
182 ss this question for NMDA receptor-dependent long-term depression (LTD) in the hippocampus.
183 ldwide and the number one cause for acquired long-term disability, resulting in a global annual econo
184      Here, we aimed to assess the effects of long-term doxycycline treatment on the aortic ultrastruc
185  current density of 20 mA cm(-2) with a good long-term durability, outperforming those assembled with
186 ment regimens that may affect both acute and long-term effects of manipulating the activity of circui
187                                 However, the long-term evolutionary consequences of decreased parasit
188 ve been masked by acclimation effects in the long-term experiment.
189 ed is poorly understood, particularly during long-term exposure.
190 a newly formed soil carbonate minerals whose long-term fate requires assessment through field trials.
191 egistry, ISRCTN10356387, and is currently in long-term follow up.
192                   We conducted a prospective long-term follow-up cohort study included 263 KTRs with
193                          Data collection for long-term follow-up is ongoing, but the trial is closed
194                     Class 1 presented during long-term follow-up with a low graft failure rate: 5% cl
195 been used with poor disease-free survival at long-term follow-up.
196 he difference in maximum walking distance at long-term follow-up.
197 igh lipid and protein oxidative stability of long-term frozen lean beef produced using stepwise in-ba
198 urotransmitter detection for the duration of long-term FSCV studies.
199  of nucleic acid drug payload for sustained, long-term gene expression or silencing.
200 n any of the passaged viruses, demonstrating long-term genomic stability of complex VSV recombinants
201  0.58; 95% CI, -2.07 to 3.22; P = 0.67), and long-term graft survival (hazard ratio, 1.07; 95% CI, 0.
202  has focused on acute care and the impact on long-term health is poorly evaluated.
203 ompared to non-operative management (NOM) on long-term healthcare utilization and survival outcomes.
204 e B-cell help and are crucial for generating long-term humoral immunity.
205                                              Long-term ICCs ranged from 0.29 (night) to 0.51 (late).
206                             We evaluated (1) long-term immunogenicity of an initial 2-dose RZV schedu
207 de feed is restored, indicating a negligible long-term impact of nitrogen oxides on the catalytic pro
208                                 However, the long-term impacts of salinization on the terrestrial wat
209                               We observed no long-term increased risks of dementia, Alzheimer's disea
210 , thus, promoting their ability to establish long-term infections and disease.
211 served anterior stromal necrosis (ASN) after long-term Intacs intracorneal ring segment (ICRS) implan
212 ive tumors that recur and commit patients to long-term invasive surveillance, to aggressive and invas
213  and LASP2 are involved in the formation and long-term maintenance of dendrites and dendritic spines.
214 nic cytomegalovirus (CMV) infection leads to long-term maintenance of extraordinarily large CMV-speci
215 ositive biological processes that facilitate long-term memories (LTM) but also the suppression of inh
216 evidence in rodents and humans suggests that long-term memory consolidation can be enhanced by the ex
217 lus, juv ELE and juv-adol ELE formed lasting long-term memory for an object location memory task, whe
218  both by their current environment and their long-term memory representations.
219   The hippocampal complex (HC) is central to long-term memory storage and retrieval as well as spatia
220 orial and may, in part, be related to poorer long-term monitoring of risk factors in nonwhite groups.
221 raumatic AKI-RRT patients had lower rates of long-term mortality (adjusted hazard ratio (HR), 0.473;
222 erative complications, and higher short- and long-term mortality (all P < 0.05).
223 cal care that induced significant short- and long-term mortality.
224                                   Conclusion Long-term MRI follow-up showed that 78% of hepatocellula
225 lent dynamics, with viruses switching from a long-term non-lethal temperate phase in healthy hosts to
226               However, most projections lack long-term observations incorporating the potential for t
227 ary efficacy for preventing chronic pain and long-term opioid use.
228  minimal perturbation to cells, ECORE allows long-term optical recording over multiple days.
229 shed in 2012, we aimed to confirm results on long-term outcome focusing on efficacy and safety of lon
230                                              Long-term outcomes are generally good; however, the risk
231 -loss, a substantial variability in achieved long-term outcomes exists among obese but otherwise heal
232    This study demonstrates ER has comparable long-term outcomes for clinical T1aN0 and T1bN0 esophage
233 of systemic steroids does not seem to worsen long-term outcomes of endophthalmitis compared to those
234 the rise in these disease entities, detailed long-term outcomes of large NAFLD-associated HCC cohorts
235                This study compared early and long-term outcomes of PCI versus CABG in patients with d
236                     Follow-up is ongoing for long-term outcomes, including efficacy and long-term saf
237                                              Long-term outcomes, including overall survival (OS), rec
238  techniques for realizing viable devices for long-term peripheral interfacing.
239 al temperatures will become critical for the long-term persistence of many plant species and communit
240                             Thus, we adopt a long-term perspective on the importance of nearby neighb
241 an develop in children and young adults with long-term PGA exposure.
242 cytotoxicity of arrestin-1 monomer, ensuring long-term photoreceptor survival.SIGNIFICANCE STATEMENT
243 BO is a significant contributor to short and long-term postoperative morbidity.
244 e role of GSK3beta in spike timing-dependent long-term potentiation (tLTP) in the chronic unpredictab
245 sufficient to mimic the effects of stress on long-term potentiation.
246  the hippocampus and neocortex, compromising long-term potentiation.
247 C storage are not well understood, hampering long-term predictions of climate C-feedbacks.
248                          We investigated the long-term prognosis following infection-related hospital
249 remains unexplored on account of the lack of long-term prospective studies from infancy to the onset
250 generate immunological memory able to induce long-term protection against disease.
251 ugh chronic implants allow for high-quality, long-term recordings in preclinical studies, the electro
252  with movement between populations, elevates long-term regional R (t) , and cumulative cases, and may
253 er two terciles seem to derive a substantial long-term relapse-free survival benefit from targeted th
254 eproduce the clinical cohort at three levels long-term response (OS), the initial response (according
255                       Evaluation of clinical long-term results 20 years after connective tissue graft
256 n is increasing, research regarding possible long-term risks for users and their offspring is needed.
257 ith follow-up to 10 years, we determined the long-term risks of recurrent stroke, disability, quality
258         The aim of this study was to provide long-term safety and efficacy data for evolocumab in pat
259 r long-term outcomes, including efficacy and long-term safety.
260 s and/or fibrotic pathways are warranted for long-term scleromyxedema management.
261 y a population of Gli1-targeted NSCs showing long-term self-renewal in the adult hippocampus.
262 ant variables measured (including short- vs. long-term sexual strategy, temporal discounting, the Ari
263 hoblastic leukemia (ALL) is efficacious, but long-term side effects are concerning.
264 e considered to maximize the added value and long-term societal impact of the next generation of sens
265           Cr(0.4) Mo(0.6) B(2) has excellent long-term stability and durability showing no significan
266 owed that 78% of hepatocellular adenomas had long-term stability or regression.
267             Prior information represents the long-term statistical structure of an environment.
268 e successful weathering of limestone and the long-term storage of the captured CO(2).
269                               Here, we use a long-term study with 106 GPS-collared free-ranging cheet
270 ollowing approval by the ethics committee, a long-term supplementation treatment was introduced.
271 pression and 2.09 (95% CI, 1.18-3.70) during long-term suppression.
272 ection; (2) PJI-related death; or (3) use of long-term suppressive antibiotics.
273 s study demonstrates the value of continuous long-term survey datasets to detect and quantify shifts
274                                              Long-term survival after minimally invasive esophagectom
275  mouse model of lung adenocarcinoma improves long-term survival and cisplatin response beyond those o
276 l complications, after MIE negatively affect long-term survival of esophageal cancer patients.
277 ow largely comparable results with regard to long-term survival, postoperative morbidity, mortality a
278  (DeltaMELD-XI) was associated with improved long-term survival.
279                      The primary outcome was long-term survival.
280 cognition and brain structure is feasible in long-term survivors of pediatric brain tumors and that m
281 nce the expression of proteins essential for long-term synaptic plasticity and memory.
282 addition increased synaptic transmission and long-term synaptic plasticity at the Cornu Ammonis (CA)
283                      These data suggest that long-term treatment with gemcitabine leads to extensive
284 g-term daily insect biomass dataset shows no long-term trends over 25 y but precipitous drops in flyi
285 m outcome focusing on efficacy and safety of long-term use of rituximab maintenance.
286                    These results suggest the long-term usefulness of rupatadine for pruritus in AD.
287                                              Long-term variability was higher than short-term variabi
288 ug resistance is a major threat to achieving long-term viral suppression in HIV-positive individuals.
289 an retinal structural outcomes predictive of long-term vision.
290 e been studied extensively in the context of long-term warming trends(14-18), they are unaccounted fo
291 -use efficiency and only slight increases in long-term water-use efficiency (+2.5%) inferred from (13
292 etabolic disorders, but the role of sleep in long-term weight loss maintenance (WLM) has not been tho
293 ents and chimeric transcripts initiated from long terminal repeats during zygotic genome activation.
294 ity function analysis indicates that several long-terminal-repeat bursts that occurred from 5.7 milli
295                    Orb2 formed ~75-nanometer-long threefold-symmetric amyloid filaments.
296    Intron retention (IR) in cancer was for a long time overlooked by the scientific community, as it
297 e, we reveal a detailed atomistic picture of long-time scale restructuring of Pd deposited on Ag usin
298 mplex spectro-temporal structure and observe long-timescale organization in communication.
299 ks, but few imaging methods can capture such long timescales.
300                                        These long-wavelength-absorbing moieties expand the applicabil

 
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