ライフサイエンスコーパス: long-held

1 ancreatic endocrine tumors are rare but have long held a fascination for clinicians because of the ph

2 While the BLAST suite of alignment tools has long held an important role in alignment-based sequence

3 ated in naive T cell survival, it has been a long-held and conceptually attractive view that they are

4 ting merozoite invasion of erythrocytes have long held appeal but failed in clinical trials.

5 ss II membrane fusogens and harken back to a long-held argument that eukaryotic sex arose as the bypr

6 of vitamin B(12) by other metals has been a long-held aspiration within the B(12) -field.

7 work (APBioNET) set out in 2015 to realize a long-held aspiration-a single, unifying bioinformatics "

8 Finally, this work calls into question the long held assumption of the obligatory involvement of hy

9 These results challenge the long held assumption that neurogenesis does not occur in

10 hin otoliths and validates a fundamental and long-held assumption in aquatic research.

11 A long-held assumption in pathogenesis of AIS is that the

12 A long-held assumption is that this ability relies on adap

13 early seventh millennium BP, contradicting a long-held assumption that agriculture was the main drive

14 Recent work has challenged the long-held assumption that appetite functions to maintain

15 These results confirm the long-held assumption that contrast gain control computes

16 ly later than most previous estimates or the long-held assumption that FANs are flotation cumulates o

17 These findings contravene the long-held assumption that genetic swamping is a common d

18 A long-held assumption that has guided the use of VEGF iso

19 This finding challenges a long-held assumption that head movements are simply an u

20 The long-held assumption that neutrophils act exclusively as

21 th the group and individual level, testing a long-held assumption that predation risk-induced behavio

22 These results challenge a long-held assumption that seizure is the primary outcome

23 described in this new publication revise the long-held assumption that superoxide is responsible for

24 wild insect populations have challenged the long-held assumption that the brevity of wild insect lif

25 This has led to the long-held assumption that ultrafast dissociation of gas-

26 r independence of lifestyle on CHD, refuting long held assumptions and unqualified beliefs.

27 the brain could use error signals and dispel long-held assumptions about algorithmic constraints on l

28 These results challenge long-held assumptions about cochlear mechanics in humans

29 Evidence has now overturned several long-held assumptions about how type I interferons are r

30 le for a simple two-state model, challenging long-held assumptions about ion channel gating models at

31 Our findings challenge long-held assumptions about milk complexity of non-human

32 le genome sequence data have overturned many long-held assumptions about the export and processing of

33 nces in soil biogeochemistry have challenged long-held assumptions about the role of soil micro-organ

34 It challenges 2 long-held assumptions that (i) Prochlorococcus cannot as

35 Recent results challenge long-held assumptions that centrosomes are essential org

36 These results challenge long-held assumptions that the centrosome and the astral

37 The results challenge the long-held axiom that pores smaller than the size of solv

38 These data argue against the long-held belief in the universality of the quantal hypo

39 For multi-subunit complexes, a long-held belief is that collisionally activated dissoci

40 A long-held belief is that the modification of the lipid A

41 at ambient conditions and suggested that the long-held belief of cation-hydration inhibition on dolom

42 overcome in the mat ground, questioning the long-held belief that atmospheric oxygenation was the ke

43 The long-held belief that degeneration of the cholinergic ba

44 Contrary to the long-held belief that DNA methylation of terminally diff

45 The long-held belief that experimental standardization beget

46 There is a long-held belief that interactions between progenitors o

47 This result has forced us to reconsider the long-held belief that invasion genes directly mediate ba

48 These results challenge the long-held belief that peptidoglycan synthesis is restric

49 ve retinal ganglion cells has overthrown the long-held belief that rods and cones are the exclusive r

50 This data challenges the long-held belief that SCFAs mainly regulate chromatin by

51 trong layering-parallel foliation, confirm a long-held belief that such rocks are a key constituent o

52 There was a long-held belief that the gram-positive soil bacterium B

53 on to the prefrontal cortex, challenging the long-held belief that the locus coeruleus is the sole so

54 To directly test a long-held belief that the macula is selectively damaged

55 A new study upturns the long-held belief that the yellow gene determines sex-spe

56 We overturn the long-held belief that these drugs act only in the skelet

57 A long-held belief was that cellular senescence decreased

58 One long-held belief was that tissue-specific translation vi

59 Contrary to long-held belief, the killer targets not only late but a

60 modeling studies have begun to question this long-held belief.

61 stage earlier than the stage 5, a previously long-held belief.

62 measurements presented here challenge these long held beliefs, finding that only modest pressures ar

63 Our findings cast doubt on long-held beliefs about adaptation.

64 Our findings challenge long-held beliefs about how order can emerge from disord

65 These data are reshaping many long-held beliefs concerning the information content of

66 concepts, especially the need to reconsider long-held beliefs in the face of new empirical findings.

67 vation by dendritic cells (DCs) has reshaped long-held beliefs of how adaptive immune responses are i

68 erstanding of genome organization, upsetting long-held beliefs on its role in transcription.

69 //B3LYP/6-311+G(d,p) level of theory support long-held beliefs that allene dimerization to 1,2-dimeth

70 pi and pcrit offers new insights, questions long-held beliefs, and opens applications from physiolog

71 Contrary to long-held beliefs, the relation between these two disord

72 The long-held but erroneous assumption of never-ending rapid

73 d neck cancer is providing new insights into long-held but poorly comprehended concepts such as field

74 These results confirm a long-held but unproven assumption that lysosomes are the

75 We set out to confirm the long-held, but untested, assumption that dietary salt af

76 This study demonstrates that, contrary to long-held clinical lore, OCA1, not OCA2, is by far the m

77 approach has been shaped by directions from long-held clinical practice guidelines and is reinforced

78 identification, thereby contributing to the long-held concept of nerve endings passing freely betwee

79 scovery to date, thereby contributing to the long-held concept of the absence of lymphatic vasculatur

80 ependence of tricuspid regurgitation (TR), a long-held concept suggested by murmur variation, remains

81 These findings challenge the long-held concept that atherogenesis involves passive mo

82 However, an unproven but long-held conjecture holds that spatial learning can occ

83 In contrast to the long-held conjecture in the experimental literature, the

84 This study satisfies the long-held conjecture that beta2M was linked to the primo

85 The long-held consensus that tetrads were the archetypal con

86 This may help resolve a long-held controversy concerning the existence of intrin

87 This confirms a core prediction of long-held cortico-basal ganglia circuit models of moveme

88 e of data and promise to satisfy biologists' long-held desire to measure absolute protein abundances

89 f the plant immune system in relation to the long-held dichotomy between Darwinian and Lamarckian evo

90 These discoveries require re-examination of long-held disease paradigms for the involvement of CysLT

91 A long-held dogma posits that strong presentation to the i

92 independently by Thomas Cech, overturned the long-held dogma that only proteins can serve as catalyst

93 Shattering the long-held dogma that organolithium chemistry needs to be

94 of astrocytes in OT signaling challenges the long-held dogma that OT acts exclusively on neurons and

95 This has led to the long-held dogma that these characteristic protein inclus

96 the cell biology of genomes have overturned long-held dogmas and have led to new models for many ess

97 developments, some of which have challenged long-held dogmas.

98 These advances have overturned two long-held dogmas: (1) only adaptive immunity confers imm

99 A long-held ecological hypothesis posits that CNDD is more

100 ntal change, can be animated by shifting the long-held emphasis on failure and collapse to a more emp

101 gineered glycan sensors may help realize the long-held goal of accurate and rapid glycoprotein profil

102 A long-held goal of synthetic biology has been the transfe

103 BACKGROUNDA long-held goal of vision therapy is to transfer informat

104 s individuals diagnosed with ADHD has been a long-held goal.

105 tissue toxicity induced by radiotherapy is a long-held goal.

106 ophyll biosynthesis, also argues against the long-held Granick hypothesis.

107 Truffles are an iconic food that have long held high regard.

108 operties and examine, in a quantitative way, long-held hypotheses concerning overall shape and functi

109 This confirmed two long-held hypotheses, firstly concerning the interactive

110 The results confirm a long-held hypothesis for the defensive function of these

111 A long-held hypothesis in regeneration proposes that devel

112 One long-held hypothesis in sequence learning suggests that

113 A long-held hypothesis is that polarization vision in open

114 A long-held hypothesis proposed that viral proteins with R

115 We tested the long-held hypothesis that a change in osmotic pressure (

116 These results support the long-held hypothesis that CTxB stabilizes raft domains v

117 suppress actions, respectively, leading to a long-held hypothesis that increased output of direct rel

118 in previous studies, calls into question the long-held hypothesis that keratinocytes increase intrace

119 tent with their ILD sensitivity supports the long-held hypothesis that LSO neurons compute a correlat

120 ions in the alveolin domain and supports the long-held hypothesis that the alveolin domain is respons

121 Here we provide evidence for a long-held hypothesis that the biogeochemical effect of u

122 duced productivity enhancement, refuting the long-held hypothesis that this effect results from growt

123 Although parasite-host co-speciation is a long-held hypothesis, convincing evidence for long-term

124 teleost relative Aetheretmon overturns this long-held hypothesis.

125 of NINJ1 as a mediator of PMR overturns the long-held idea that cell death-related PMR is a passive

126 se findings provide genetic evidence for the long-held idea that the cap guanylate is critical for mR

127 The results are inconsistent with the long-held idea that the replacement of His-143(beta) in

128 However, recent findings have questioned long-held ideas on how these circuits perform this funda

129 Long-held ideas regarding the evolutionary relationships

130 ice provision are forcing a reexamination of long-held ideas.

131 irst proposed more than two decades ago, has long held immense promise for targeted cancer therapy.

132 now supports certain fundamental assumptions long held in the pediatric community.

133 f different salts that demonstrate that this long-held interpretation needs to be modified.

134 faunal, and chronological data have upended long-held interpretations regarding the emergence of foo

135 Despite the long-held knowledge of its existence, little is known ab

136 instability as cancer causes rather than the long-held Knudson's 'two-hit' hypothesis; the evidence t

137 Besides providing a new perspective on the long-held mechanism of polishing, our observations provi

138 This duality of action converges the long-held mechanistic dichotomy between adhesive matrix

139 Long-held misconceptions about the use of background sub

140 These findings are challenging long-held models of vesicular transport of large matrix

141 mmonia oxidation) Nitrospira has upended the long-held nitrification paradigm.

142 This new methodology matches the long held notion that CNTs are rolled up graphene layers

143 The long held notion that hexenyl radicals bearing large sub

144 This long-held notion has recently been challenged by biologi

145 This challenges the long-held notion of the dominance of Fusobacterium nucle

146 This assertion, in part, led to a long-held notion that hops require vernalization and/or

147 s, the resolution achieved has supported the long-held notion that immune cells are naturally organiz

148 In addition, we challenge the long-held notion that shade-tolerant, late-successional

149 o gamma-NiOOH and consequently challenge the long-held notion that the beta-NiOOH phase is a more eff

150 ebellum and basal ganglia has challenged the long-held notion that these structures function independ

151 , inducing angiogenesis, was born out of the long-held notion that tumours could grow only if new ves

152 Our insights challenge the long-held notion that vertebrate cone diversity primaril

153 lt is discussed with regard to reformulating long-held notions about excited-state relaxation, as wel

154 e and neuroimmune interfaces are challenging long-held notions of CNS immune privilege, with direct r

155 These viral imprints have upended long-held notions of the age and mutation rate of viruse

156 at the cortical network, contributing to the long-held observation that the cortical actin cytoskelet

157 tence of an ion-mediated response breaks the long-held paradigm of the xylem as a system of inert pip

158 It is a long-held paradigm that cell fusion reprograms gene expr

159 Taken together, these data argue against the long-held paradigm that malaria infection is pathogenic

160 verse than assumed hitherto, overturning the long-held paradigm that the early endophytes were exclus

161 We have uncovered an important twist to this long-held paradigm: the complete absence of liver synthe

162 el lymph node (SLN) biopsy are changing this long-held paradigm; indeed, several leading institutions

163 Taken together, our findings challenge the long-held perception of eosinophils as cytotoxic in dyst

164 We therefore argue, contrary to long-held perception, that large-volume silicic volcanis

165 The long-held poor understanding of their genetics and evolu

166 sequences of this finding with regard to the long-held postulate of the universality of the small-sca

167 findings substantiate for the first time the long-held presumption that cap methylation is an essenti

168 These experiments correct the long-held presumption that the quantum yield in vision i

169 A long-held principle is that gradients guide cells via re

170 The hen has long held promise as a low cost, high-yield bioreactor f

171 The hen has long held promise as a low-cost, high-yield bioreactor f

172 Gene therapy has long held promise as a method for targeted alteration of

173 tanding of psychosine synthesis, confirm the long-held psychosine hypothesis, and provide the impetus

174 A long-held question has been how these different modes of

175 The recent progress provides answers to long-held questions, identifies intriguing new behaviour

176 tive "Holy Grail;" however, there has been a long-held scientific dogma that revascularization of the

177 A long-held set of principles describes this process: lexi

178 However, a second and equally long-held stigma attached to mental illness has been ano

179 rough probiotic supplementation represents a long-held strategy towards ameliorating disease via inte

180 The long-held structural correlation of this regulation has

181 A long-held structure-property relationship is that centro

182 The findings support the long-held supposition that hippocampal neurons play a cr

183 ermal bone covering the adductor chamber has long held sway in amniote systematics, and still represe

184 A long-held tenet in inositol-lipid signaling is that clea

185 A long-held tenet in physics asserts that particles intera

186 A long-held tenet of heterotrimeric G protein signal trans

187 A long-held tenet of molecular pharmacology is that canoni

188 A long-held tenet of neuromuscular transmission is that ca

189 from reproductive cell death, supporting the long-held tenet that DNA damage is the cause of reproduc

190 virus and hepatitis E virus challenges this long-held tenet.

191 Although the literature has long held that a floor fracture seen radiographically to

192 s contradicts the prevailing view, which has long held that amphibian B neurons are singly innervated

193 The prevailing consensus has long held that branching networks are optimized and exhi

194 It is long held that G protein function is localized to the pl

195 The classical model of hematopoiesis has long held that hematopoietic stem cells (HSCs) sit at th

196 Clinical observation has long held that TBI can accelerate fracture healing, yet

197 Normative and scientific guidance has long held that very high IRS coverage (at least 80 to 85

198 Magnetoencephalography has long held the promise of providing a noninvasive tool fo

199 des the polychaetes and the clitellates, has long held the taxonomic rank of phylum.

200 A bold reappraisal of human history upends long-held theories about early societies.

201 In this study, we directly test long-held theories about encoding of sensorimotor stimul

202 ts provide structural evidence in support of long-held theories concerning the evolution of antigen r

203 In this study, we substantiate long-held theories regarding the advantages and disadvan

204 These findings support long-held theories that the brain correlates of stutteri

205 isomers with primary esters, challenging the long-held thought that BMP stereochemistry alone ensures

206 There is growing evidence that astrocytes, long held to merely provide metabolic support in the adu

207 d from two distinct sites, which expands our long-held understanding of mitochondrial gene expression

208 l transitions have brought into question the long held view of the basal transcriptional apparatus as

209 In light of our findings, the long held view that considers NE as a prime suspect in P

210 Collectively, our studies contradict the long held view that potent inhibitors of glycosidases mu

211 molecular paleothermometer, challenging this long held view.

212 A recent report casts doubt on this long-held view by showing that reversible inactivation o

213 In this study, we challenge a long-held view concerning the pattern of inhibitory inpu

214 Thus, the long-held view is that intrusions must precede and feed

215 The long-held view is that Slits push growth cones forward a

216 A long-held view is that stroke causes many distinct neuro

217 For T-type Ca(2+) channels, a long-held view is that they are not regulated by intrace

218 A long-held view is that unstable electrodeposition is a c

219 Our findings depart from the long-held view of an exclusive association between Sur1

220 Shale-type deposits and emphasizes that the long-held view of Burgess Shale-type faunas as snapshots

221 New discoveries challenge the long-held view that aging is characterized by progressiv

222 The long-held view that bipolar cells provide the exclusive

223 Previously, we reported evidence that the long-held view that catalytic competence develops synchr

224 Our results challenge the long-held view that chameleons originated on Madagascar

225 rovides an explicit neural mechanism for the long-held view that directed saccades support hypothesis

226 es crucial empirical evidence supporting the long-held view that elevated inflammation may be central

227 These data are consistent with the long-held view that human LVNC may result from compactio

228 Although it is a long-held view that lithium corrosion in electrolytes in

229 The long-held view that many autoimmune disorders are primar

230 align with, and provide mechanisms for, the long-held view that memories are established and consoli

231 mammary gland morphogenesis and support the long-held view that mesenchymal signal(s) are responsibl

232 rentiation to macrophages or DCs, revising a long-held view that monocytes become tissue-resident mac

233 Contrary to the long-held view that most humans harbour only identical m

234 peppered moth Biston betularia that test the long-held view that prey have evolved postures that enha

235 These findings challenge the long-held view that protistan grazing mainly determines

236 Although it has been a long-held view that psychopharmacological approaches wor

237 Challenging the long-held view that rapid endocytosis offers a rapid, lo

238 Our results force us to reconsider the long-held view that Salmonella effector proteins must be

239 These conclusions overturn a long-held view that such EPR signals in bovine cytochrom

240 This is in contrast to the long-held view that supergenes are likely to be controll

241 ts in more than one gene have challenged the long-held view that the disorder is strictly monogenic,

242 Recent data fit with the long-held view that the polymorphism of this region is d

243 Our findings do not support the long-held view that the reason why HPV-18 infection is u

244 Notably, the new findings support the long-held view that these tumors distinctively arise fro

245 ercussions on two fronts: 1) It supports the long-held view that turgor pressure is the main force dr

246 A recent study has overturned a long-held view that two distinct modifications to photos

247 ) signaling in the heart, and challenges the long-held view that voltage-gated channels open and clos

248 ophysiological measurements that refute this long-held view.

249 g-induced muscle FAO adaptation, challenging long held views of mechanisms involved in acute and adap

250 recent molecular study, however, challenges long-held views and shows that molecular patterning mech

251 cts and recent data, which suggest that some long-held views must be re-evaluated.

252 em variations at Olduvai Gorge contrast with long-held views of directional or stepwise aridification

253 ances in neuroscience increasingly challenge long-held views of the self and the individual's relatio

254 also in excellent qualitative agreement with long-held views regarding the nature of the hydrolysis m

255 ean termites reveal a picture different from long-held views, especially those concerning colony bree

256 Contrary to these long-held views, here we show that single neurons in bot