ライフサイエンスコーパス: long-sought

1 The long-sought 17 e (-) radical cation of the parent comple

2 crofluidic and nanofluidic technologies have long sought a fast, reliable method to overcome the crea

3 Ecologists have long sought a way to explain how the remarkable biodiver

4 ue U C-bearing molecules are examples of the long-sought actinide-alkylidynes.

5 le synthesis of aminodiborane will make this long-sought active chemical reagent readily available fo

6 c phospholipase C (PLC), PLCzeta, may be the long sought after [Ca2+]i oscillation-inducing SF.

7 , we suggest that Ded1p may be a part of the long sought after activity shown to promote yeast viral

8 ndez et al. and Renton et al.) show that the long sought after ALS/FTD mutation on chromosomal region

9 they provide experimental confirmation of a long sought after animal model of HDFN.

10 wires and their facile fabrication have been long sought after as they promise to offer substantial i

11 transmembrane aspartic proteinase to be the long sought after beta-secretase.

12 The long sought after but elusive efficient and selective ox

13 gstrom, and ultrafast temporal duration, the long sought after but hitherto unrealized quest for ultr

14 vidence presented here establishes PilZ as a long sought after c-di-GMP-binding domain and YcgR as a

15 control organ size and may, in fact, be the long sought after chalones, or negative growth regulator

16 se results indicate that TORC2 is one of the long sought after cofactors that mediates the differenti

17 ).The generation and characterization of the long sought after ferriheme peroxynitrite complex has be

18 Using this approach, we discovered the long sought after folic acid receptor, fAR1, in D. disco

19 CNS regeneration in higher vertebrates is a long sought after goal in neuroscience.

20 hat may take us one large step closer to the long sought after goal of separating GVL and GVHD.

21 gene, RNASEL, as a strong candidate for the long sought after hereditary prostate cancer 1 (HPC1) al

22 a long Abeta species that is most likely the long sought after intermediate product, Abeta(49), gener

23 implicated roles for a new protein PIEZO1, a long sought after mammalian mechanosensory protein; GLUT

24 We propose that md-L neurons are long sought after mechanoreceptor cells through which fo

25 n may provide a platform for the design of a long sought after monovalent form of avidin, which would

26 These data provide long sought after near-atomic resolution insights into h

27 ealed by the present study, point toward the long sought after physiological and pathophysiological r

28 critical for NAADP action and is likely the long sought after target channel for NAADP.

29 pore channel (TPC) family in mammals are the long sought after target channels for NAADP.

30 that this system will be able to detect the long sought after vacuum friction(7-10) near a surface u

31 cs to become that enabling technology for so long sought after.

32 One long-sought after nanotechnology is systems able to achi

33 mutant p53 using small molecules has been a long sought-after anticancer therapeutic strategy.

34 (HSCs) from renewable cell types has been a long sought-after but elusive goal in regenerative medic

35 adiene (COD) or norbornadiene (NBD), yielded long sought-after cationic bis(phosphine) cobalt complex

36 identification, and characterization of the long sought-after Criegee intermediate for each system,

37 Thus, we propose that PARI is a long sought-after factor that suppresses inappropriate r

38 Dirac electrons-a mechanism analogous to the long sought-after Higgs mechanism in particle physics.

39 between MSK1, Trim7 and RACO-1 completes the long sought-after mechanism linking growth factor signal

40 coworkers (Cell Rep., 2019) have generated a long sought-after molecular atlas of vagal afferents in

41 scriptional repression of 15-PGDH elucidates long sought-after molecular mechanisms that govern PG ac

42 These results provide support for DEK as a long sought-after oncogene mapping at chromosome 6, with

43 rol of the apoptotic machinery, and reveal a long sought-after oncogenic event conferring sensitivity

44 mics simulations identify the origin of this long sought-after regime as a planar, torsion-free backb

45 box E3:E2~Ub ligase complex and identify the long sought-after source of allostery for RING/U-Box act

46 and indicates that it is a candidate for the long sought-after tubulin tyrosine carboxypeptidase impo

47 urons of the RTN are good candidates for the long sought-after VMS chemoreceptors.

48 Therefore, pHLA-target Ags may represent the long sought-after, ideal targets for solid tumor targeti

49 The long sought-after, intrinsically short-lived molecule et

50 to synthesize a fluorinated polyacetylene, a long-sought-after air-stable polyacetylene that has elud

51 thylene with functionalized co-monomers is a long-sought-after approach to introducing polyolefin fun

52 The structure reveals the long-sought-after catalytic Phi-clamp and the membrane-s

53 These findings identify a long-sought-after critical component of the nephron stem

54 hemically and thermally stable, yet have the long-sought-after design flexibility offered by function

55 OMM, not BH3-only proteins or p53/Rb, is the long-sought-after direct activator of Bax/Bak following

56 This important work not only identifies a long-sought-after dorsalizing factor but also highlights

57 e to that of Ni(II) complexes, serves as the long-sought-after experimental support for the proposed

58 SO/FAIM3 recently has been identified as the long-sought-after FcR for IgM (FcmuR).

59 SSM electrophysiology provides a long-sought-after functional assay for the ubiquitous am

60 man pluripotent stem cells (PSCs) has been a long-sought-after goal for use in hematopoietic cell pro

61 ired after serial DENV infections has been a long-sought-after goal for vaccination.

62 One of the long-sought-after goals in light manipulation is tuning

63 l greenhouse effect, which may represent the long-sought-after historical analog to the carbon dioxid

64 ter from Pyrococcus furiosus (PfMATE) in the long-sought-after inward-facing state, which was obtaine

65 nse that, with continued study, might reveal long-sought-after keys to achieving CNS repair.

66 ne responses and are being championed as the long-sought-after mechanism for host-induced gene silenc

67 DNA structures in mutagenesis and reveal the long-sought-after mechanism of complex mutations that re

68 as developmental signals but also identify a long-sought-after mechanism that initiates Pax6 in placo

69 bolically unstable LBR variants may serve as long-sought-after model substrates enabling previously i

70 with a ubiquitinated nucleosome provide the long-sought-after molecular mechanism of Dot1L-mediated

71 A single-molecule electret is a long-sought-after nanoscale component because it can lea

72 s that are missing in chicken, including the long-sought-after nephrin and tumor necrosis factor gene

73 These findings not only identify the long-sought-after osteoclast progenitors but also establ

74 ation of EcNhaA, we sample what could be its long-sought-after outward-facing conformation and verify

75 Arabidopsis thaliana UVR8 (AtUVR8) is a long-sought-after photoreceptor that undergoes dimer dis

76 A long-sought-after reactive monophosphine-ligated palladi

77 Therefore, Cyclin B1 is the long-sought-after scaffold that links MAD1 to the corona

78 hat lamin B is a structural component of the long-sought-after spindle matrix that promotes microtubu

79 Our study essentially identifies a long-sought-after structural glass order in hard-sphere

80 For example, recent work suggests that the long-sought-after target of the analgesic acetaminophen

81 o recent papers reported identification of a long-sought agrin coreceptor, Lrp4 (Kim et al. in Cell a

82 They could thus provide a long-sought anatomical link for understanding homeostati

83 eukaryotes implicates eukaryotic RtcB as the long-sought animal 3'-P RNA ligase.

84 This finding provides a long-sought answer to the question of how dermal cells m

85 us, the mcDC subset appears to represent the long-sought APC responsible for breaking peripheral tole

86 e analysis suggests that ERH1 may encode the long-sought Arabidopsis functional homolog of yeast and

87 Cellulose has been long sought as a chiral inducer in enantioselective cata

88 This microstructure has been long-sought as it provides an opportunity to incorporate

89 The vPAG dopaminergic cells may provide the long-sought ascending dopaminergic waking influence.

90 Their structures have been long sought because of their potential as drug targets i

91 ngiopoietin-like protein 8 (ANGPTL8) was the long-sought "betatrophin" that could control pancreatic

92 Rapid, quantitative Western blotting is a long-sought bioanalytical goal in the life sciences.

93 In addition to uncovering a long sought biological function for Old Yellow Enzyme, t

94 terization of a 1,3-dihydro-1,3-azaborine, a long-sought BN isostere of benzene.

95 ent discovery of strigolactones (SLs) as the long-sought branch-inhibiting hormone allowed us to test

96 regulation and on the dephosphorylation of a long sought but still unidentified substrate.

97 nsient scenes at high imaging speed has been long sought by photographers, with early examples being

98 ment, an oxidant was developed such that the long-sought C60.+ ion can be synthesized in solution.

99 assembled by HPV E2 and turns out to be the long sought cellular corepressor that inhibits the expre

100 These results show that BMPs may be the long-sought 'chalone' inhibitors of hair growth postulat

101 transporters, implicating it as (one of) the long-sought Cl-/volume-sensitive kinase(s).

102 at WNK3-SPAK is an integral component of the long-sought "Cl(-)/volume-sensitive kinase" of the catio

103 ear, candidates have been identified for two long-sought classes of molecules, insect odorant recepto

104 We identify Bothrioplanida as the long-sought closest free-living sister group of the para

105 ency and may be relevant to development of a long-sought "cocaine antagonist".

106 The proteins STIM1 and Orai1 are the long sought components of the store-operated channels re

107 e propose that these cells correspond to the long-sought components of the cerebrospinal fluid chemos

108 Our results indicate that PCSK6 is the long-sought corin activator and is important for sodium

109 operated currents and that CRACM1 may be the long-sought CRAC channel.

110 Here we present the long sought crystal structure of the PLB-SERCA complex a

111 We identify this FQHE state as the long-sought CSL with a uniform chiral order spontaneousl

112 The long-sought cubic gauche phase of polymeric nitrogen (cg

113 ) show that the Aurora A kinase AIR-1 is the long-sought cue that downregulates cortical actomyosin t

114 light-emitting diode (spin-OLED) has been a long-sought device within the field of organic spintroni

115 nstein condensate (BEC), which resembles the long-sought Dicke QPT.

116 and the optogenetic repertoire along several long-sought dimensions.

117 Our findings identify Sox5 as the long-sought DNA-binding partner for BMP R-Smads essentia

118 We conclude that IREG1 represents the long-sought duodenal iron export protein and is upregula

119 oronal intensity, which is suggestive of the long-sought dust free zone(9-11).

120 Our studies identify a long-sought enzyme that plays a critical role in PC remo

121 and chronicles, we argue the source of this long-sought eruption is the Samalas volcano, adjacent to

122 Our results provide the long sought evidence for understanding the formation of

123 The results provide long-sought evidence for two evolutionary hypotheses: sp

124 We conclude that Par3 is the long-sought exocyst receptor required for targeted membr

125 Majorana fermions are long-sought exotic particles that are their own antipart

126 This might provide the long-sought experimental basis for a generally accepted

127 These data provide long-sought experimentally derived constraints for high-

128 ayer in antiviral innate immunity provides a long-sought explanation for delayed activities of respec

129 The results provide a long-sought explanation for why PTAP duplications arise

130 ar petrology, UH154-11 can be considered the long-sought first melt produced during partial different

131 e temporal optogenetics control, achieving a long-sought flexibility beyond the means of conventional

132 and photomechanical) response deliver on the long sought for dynamic all-organic optical elements to

133 unctional biology, a linkage scientists have long sought for more complex systems.

134 he most red-shifted channelrhodopsins known, long-sought for optogenetics, and more broadly the most

135 n be related to their characteristic size, a long sought-for length scale.

136 Thus, we identify the long-sought foreign ligand for this key immunoregulatory

137 e vicinity of the impurity atoms reveals the long-sought four-fold symmetric quasiparticle 'cloud' al

138 Our results suggest that BDNF may perform a long-sought function for a secreted growth factor in med

139 dc48, Ufd1 and Npl4 action not only provides long-sought functions for these specific proteins, but i

140 s from molecule-like to bulk-like has been a long sought fundamental question in science, since Farad

141 These characteristics indicate that the long-sought gene and polypeptide harboring the FA- and F

142 These data provide a long-sought glimpse of the hyperpolarized state of a fun

143 the lysosomal arylsulfatase G (ARSG) is the long-sought glucosamine-3-O-sulfatase required to comple

144 id microfluidic-based separations has been a long-sought goal for applications in proteomics, genomic

145 rategies for inducing beta-cell expansion, a long-sought goal for diabetes therapy.

146 It has been a long-sought goal in cluster science to discover stable a

147 eration of beta cell endocrine function is a long-sought goal in diabetes research.

148 A long-sought goal in metallic glasses is to impart ductil

149 gh-quality entangled photon pairs has been a long-sought goal in modern quantum communication and com

150 tal realization of quantum spin liquids is a long-sought goal in physics, as they represent new state

151 sm to achieve orderly recruitment has been a long-sought goal in physiology, medicine and engineering

152 A long-sought goal in structural biology has been the imag

153 onal proteins to specific DNA sequences is a long-sought goal in the study and engineering of biologi

154 k gives a new approach towards achieving the long-sought goal of a predictive capability for bulk met

155 ME-PBM achieves the long-sought goal of connecting such now available experi

156 chitecture of bacterial epidemics has been a long-sought goal of infectious disease research.

157 rd's transfer model, we demonstrate that the long-sought goal of predicting solvent-dependent coopera

158 odel and newly determined GTFEs achieves the long-sought goal of predicting urea-dependent cooperativ

159 It has been a long-sought goal of quantum simulation to find answers t

160 in seismically active fault zones has been a long-sought goal of seismology.

161 ty in well-defined neuronal populations is a long-sought goal of systems neuroscience.

162 nanophotonics and atomic physics has been a long-sought goal that would open new frontiers for optic

163 constituted synaptic proteins that meets the long-sought goal to produce fast content release in the

164 cally active valence electron densities is a long-sought goal, as these electrons dictate the course

165 y neutralizing antibodies against HIV-1 is a long-sought goal.

166 r principles of synaptic vesicle fusion is a long-sought goal.

167 tron spin using electron spin resonance is a long-sought goal.

168 ze membrane proteins in a lipid bilayer is a long-sought goal.

169 inities between antibodies and antigens is a long-sought goal.

170 s) with their physical properties has been a long-sought goal.

171 broad HIV neutralizing activity of the mAbs, long sought goals in HIV vaccine development.

172 through postexposure immunotherapeutics are long-sought goals.

173 h these TMCs as pore-forming subunits of the long-sought hair-cell transduction channel.

174 (6)X(6)(-) (X = Cl, Br), allow access to the long sought, highly electrophilic diethylaluminum moiety

175 l of sequence profiles indicated Ac45 as the long-sought human homologue of yeast V-ATPase assembly f

176 Our studies elucidate a long-sought Igh V(D)J recombination control region and i

177 sm exhibited by the material system has been long sought in ophthalmic applications such as photochro

178 A long-sought insight from these results is that during Ho

179 (GPCRs) have flourished recently, providing long-sought insights into the dynamic process of guanine

180 odies with known epitopes, we documented the long-sought interaction between gD and gH/gL, detailing

181 ia diborane (NH(3)BH(2)(mu-H)BH(3), AaDB), a long-sought intermediate proposed for the formation of D

182 pproach has resulted in the isolation of the long sought intermediates, cobalt-precorrin-6A and -6B a

183 The discovery of these long-sought intermediates paves the way for defining the

184 Our data indicate that HCP 1 is the long-sought intestinal heme transporter.

185 Our work indicates that ankyrin is a long-sought intracellular tether that transmits force to

186 These observations suggest that EFCAB9 is a long-sought, intracellular, pH-dependent Ca(2+) sensor t

187 be a new mediator of innate immunity and the long-sought iron-regulatory hormone.

188 This study demonstrates that RPE65 is the long-sought isomerohydrolase and fills a major gap in ou

189 TREK-1 as being the major components of the long-sought K(+) channels underlying the passive conduct

190 summary, we demonstrate that FAM173A is the long-sought KMT responsible for ANT methylation at Lys-5

191 n summary, we have identified FAM173B as the long-sought KMT responsible for methylation of ATPSc, a

192 udy suggests that GRPR+ neurons constitute a long-sought labeled line for itch sensation in the spina

193 These data delineate a long-sought ligand- and ubiquitin-independent mechanism

194 This concordance provides a long-sought link between gamma oscillations, cortical pl

195 -containing nuclear membrane proteins as the long-sought linker between microtubules and the nucleus

196 r, and hence their reorientations embody the long-sought local zero energy modes for the pyrochlore l

197 t can be hypothesized that BMPs might be the long-sought "luteinization inhibitor" in Graafian follic

198 uggest that RhBG homologous proteins are the long sought major ammonium transporters in mammalians.

199 e superconductor is predicted to produce the long-sought Majorana quasiparticle excitations.

200 Behavioral scientists have long sought measures of important psychological construc

201 Together, our data provide a long sought mechanism as to how defects in Sac1p overcom

202 ndings elucidate the molecular evolution and long-sought mechanism of GPR4, GPR65, and GPR68 pH sensi

203 In summary, this study has uncovered a long-sought mechanism of HCV cell-culture adaptation and

204 lies required both for processes and for the long-sought mechanism of initiation of starch granules.

205 walls of the Golgi yields insights into the long-sought mechanism of transport through this organell

206 Our data provide a long-sought mechanism underlying the resolution of LPS-i

207 nt, with the ultimate goal of unraveling the long-sought mechanisms that support the emerging complex

208 metaphase of meiosis II and seems to be the long-sought mediator of CSF activity.

209 ates that the long noncoding RNA DINO is the long-sought missing link between HPV16 E7 and elevated T

210 Most recently, two breakthroughs in the long-sought molecular bases of alkane formation and poly

211 Our analysis defines the long-sought molecular function for the zillion different

212 e to induce flowering under LDs, providing a long-sought molecular knob that links developmental agin

213 ough cell growth in G(1) provides one of the long-sought molecular mechanisms that promotes cell size

214 hesis that transmembrane channel-like 1 is a long-sought MT channel subunit.

215 ce strongly suggests that follistatin is the long-sought mTOR-regulated fusion factor.

216 These findings reveal a long-sought myogenic fusion protein that controls mammal

217 chardt correlator, revealing elements of the long-sought neural substrates of motion detection in the

218 Thus, we propose that R-spondin-2 may be the long-sought neuronal factor that acts on taste stem cell

219 It exploits the long sought non-trivial non-radiating charge-current exc

220 aptive cellular structure is responsible for long-sought non-dissipative (hysteresis-free), linearly

221 hem to design and produce a new polymer is a long-sought objective of polymer scientists.

222 ides in an MHC-like fashion has revealed the long-sought odorants used to recognize the MHC genotype

223 3d, which shows all expected features of the long-sought oncogene interacting locus.

224 herefore supports a new route to realize the long-sought opportunities offered by molecular structure

225 istinctive macrocyclic environment creates a long-sought opportunity to trap unique organometallic tr

226 y success of bats, and palaeontologists have long sought osteological correlates of echolocation that

227 Determination of the long-sought oxidized desaturase crystal structure facili

228 Elusive diphosphorus tetroxide, the long sought phosphorus analogue of N2O4, is particularly

229 thus suggest that SRD5A3 is likely to be the long-sought polyprenol reductase and reveal the genetic

230 Neonatologists and pulmonary biologists have long sought preventive treatments for bronchopulmonary d

231 roscopic and kinetic characterization of the long-sought principal intermediate involved in this proc

232 Our findings suggest that corin is the long-sought pro-ANP-converting enzyme and that the corin

233 demonstrate that merging neutron stars are a long-sought production site forging heavy elements by r-

234 ich forms LPA, may form a key element of the long-sought pruritogenic signaling cascade in cholestati

235 etic field and doping, that it cannot be the long-sought pseudogap state.

236 arrangement of FSO(2)N was observed, but the long-sought radical FSO(2) (22%) and traces of SO(2) (3%

237 e unequivocally reveal the structure of this long-sought radical species through the use of electron

238 epresents a molecular "living fossil" of the long-sought RAG transposon.

239 ns (<1 mug/l; nM range), thereby providing a long-sought rationale for their health protecting effect

240 , identify a family of F box proteins as the long-sought receptors for the plant growth hormone auxin

241 GPR107 might be one of the long-sought receptors that associates with G-proteins to

242 in oligodendrocytes, we identify QKI as the long-sought regulator of Neurofascin alternative splicin

243 The long-sought relativistic phenomenon of massless Dirac fe

244 LTP) raises the question whether this is the long-sought resetting mechanism for long-term depression

245 degradation of structured RNA and may be the long sought RNA-degrading complex in the mammalian mitoc

246 her, these data demonstrate that RtcB is the long-sought RNA ligase that catalyzes unconventional RNA

247 Our results uncover a long-sought role for ORAI2 and ORAI3, revealing an intri

248 Here we describe a long-sought route through ribose aminooxazoline to the p

249 Here we show that activin A is the long-sought second negative muscle regulator.

250 activation of these channels and may be the long sought sensor of calcium store content.

251 Chemists have long sought sequence-controlled synthetic polymers that

252 n Pancrustacea we identify Xenocarida as the long-sought sister group to the Hexapoda, a result confi

253 ree reconstitution experiment in real time a long-sought SNARE assembly intermediate in which only th

254 ApSOD further provides the structure of a long-sought SOD product complex at 1.35 A resolution, su

255 ochemical platform is anticipated to offer a long sought solution for single-molecule sensing with im

256 This long-sought solution to Darwin's dilemma was set in moti

257 We conclude that a long-sought specific DNA sequence within X-linked genes

258 These results are a long-sought step for the field of regenerative medicine;

259 Thus, rootletin is the long-sought structural component of the ciliary rootlet.

260 This work reveals long-sought structural differences between the pre-accom

261 ent of antimycobacterial agents against this long-sought target.

262 Thus, vasohibin/SVBP complexes represent long-sought TCP enzymes.

263 Geneticists have long sought the ability to manipulate vertebrate genomes

264 Chemists have long sought the ability to modify molecules precisely wh

265 Biologists have long sought the genes that contribute to phenotypic and

266 Abeta1-x peptides and, therefore, has been a long- sought therapeutic target for treatment of AD.

267 Ecologists have long sought to account for the patterns observed in spec

268 of metal-organic frameworks (MOFs) have been long sought to advance the application of MOFs in variou

269 though death is inevitable, individuals have long sought to alter the course of the ageing process.

270 Microbial ecologists have long sought to associate the transformation of compounds

271 Visual neuroscience has long sought to determine the extent to which stimulus-ev

272 lly harsh reaction conditions, chemists have long sought to develop catalytic variants based upon the

273 Neuroscientists have long sought to elucidate the molecular underpinnings of

274 Population geneticists have long sought to estimate the distribution of selection in

275 Geneticists have long sought to identify the genetic changes that made us

276 Medicine has long sought to match diagnostic and treatment approaches

277 New electron-acceptor materials are long sought to overcome the small photovoltage, high-cos

278 Researchers have long sought to structurally characterize dynamic process

279 Biologists have long sought to trace this cell lineage tree in individua

280 Evolutionary biologists have long sought to uncover the adaptive origins of 'homosexu

281 Neurobiologists have long sought to understand how circuits in the nervous sy

282 Scientists have long sought to understand how vascular networks supply b

283 Evolutionary biologists have long sought to understand the relationship between micro

284 Scientists have long sought to understand what is the origin of egocentr

285 Neurologists have long sought to understand what precipitates individual s

286 Biologists have long sought to understand which genes and what kinds of

287 eukaryotes, with no off-target effects, is a long-sought tool for molecular and systems biologists.

288 f the Kramers point and can be driven to the long-sought topological spin transport regime.

289 thylaniline (DMA) radical cation DMA(.+) , a long-sought transient intermediate, was detected by mass

290 Long-sought transporters involved in mitochondrial calci

291 gth sorting technique shows a path to attain long-sought ultralong, electronically pure carbon nanotu

292 theory is the most promising approach to the long-sought unified description of the four forces of na

293 all organics, the technique could become the long-sought universal soft ionization method.

294 ented accuracy, thus opening the door to the long-sought "universal model" capable of describing the

295 buted among kingdoms and are proposed as the long-sought vacuolar phytochelatin transporters in plant

296 today monoclonal antibodies have emerged as long-sought vehicles for the targeted delivery of potent

297 The data presented here identify H(v)1 as a long-sought voltage-gated H+ channel and establish H(v)1

298 Excitonic condensate has been long-sought within bulk indirect-gap semiconductors, qua

299 coding a tumor suppressor protein within the long-sought WT2 locus.

300 for the treatment of human cancer has been a long sought, yet elusive, strategy.