ライフサイエンスコーパス: longevity

1 l polymer length of vHMM-HA is important for longevity.

2 t are regulated by the endo siRNAs to affect longevity.

3 microbial metabolism is associated with host longevity.

4 behavior, associative learning, immunity and longevity.

5 amics, and lysosomal signaling in regulating longevity.

6 Their breakdown is favoured by longevity.

7 nges in complex life history traits, such as longevity.

8 nships between male song, age, survival, and longevity.

9 often invest the bare minimum in defense or longevity.

10 e responses of maximal breadth, potency, and longevity.

11 ty of higher relative profit increasing with longevity.

12 defining the complex mechanisms of aging and longevity.

13 a design of new HTMs for PSCs with improved longevity.

14 are involved in regulation of soil seedbank longevity.

15 gulating organismal ER stress resistance and longevity.

16 e ZMPSTE24 is important for human health and longevity.

17 tamatergic or cholinergic neurons, increases longevity.

18 eotide excision repair (NER), coevolves with longevity.

19 ng metabolic fitness, redox homeostasis, and longevity.

20 sting whether song is associated with age or longevity.

21 merging as potential influences on aging and longevity.

22 such as age-related macular degeneration and longevity.

23 beneficial effect of autophagy in promoting longevity.

24 , improve metabolic parameters, and increase longevity.

25 , organelle interactions, and the control of longevity.

26 o intrapopulation variation in mortality and longevity.

27 ared genetic architecture between health and longevity.

28 e materials to improve their performance and longevity.

29 tein aggregates in aged flies, and increases longevity.

30 ctors affecting human disease and ultimately longevity.

31 rgo senescence, and can also exhibit extreme longevity.

32 ble target to test for strategies to promote longevity.

33 n the origin of life and the upper limits to longevity.

34 s ranging from cell growth and metabolism to longevity.

35 lish a unified perspective on senescence and longevity.

36 sue-specific expression of multiple genes in longevity.

37 on to evaluate the likelihood of exceptional longevity.

38 e span and greater likelihood of exceptional longevity.

39 beneficial effect of autophagy in promoting longevity.

40 e and improving neural recording quality and longevity.

41 rosine degradation pathway as a regulator of longevity.

42 eplicated gene associated with extreme human longevity.

43 auer larva, a diapause stage associated with longevity.

44 preted in the context of children's relative longevity.

45 ay be the most potent threat to survival and longevity.

46 ms that connect long-term fat oxidation with longevity.

47 long periods without deleterious effects on longevity.

48 putative benefits for disease prevention and longevity.

49 dulate lipid accumulation independently from longevity.

50 d collagen membranes, which reduces membrane longevity.

51 tolerance, entry into a quiescent state and longevity.

52 h profound effects on cellular lifestyle and longevity.

53 ptoms of these pathologies and even promotes longevity(1,2,8-10).

54 lated cardiomyopathy and terminal HF (median longevity, 28 weeks).

55 ridity, as well as a pronounced reduction in longevity above mean annual temperatures of 25.4 degrees

56 t an organism remains healthy) and increases longevity across species.

57 assess how climate controls growth and tree longevity across world biomes.

58 l network that balances stress responses and longevity against reproduction during developmental tran

59 We measured maximum floral longevity alongside protandry, flower size, flower numbe

60 predict annual reproductive success (ARS) or longevity among adult female spotted hyenas Crocuta croc

61 We validated our pillar-based device with longevity analyses of classical aging mutants (daf-2, ag

62 vide an excellent model to study traits like longevity and age-related diseases.

63 r non-traditional model, particularly in the longevity and cancer research fields.

64 Genes involved in both longevity and cardiovascular diseases, taken as a paradi

65 hree disjoint networks that regulate healthy longevity and dissociable systems of learning and memory

66 Due to its longevity and enormous information density, DNA is an at

67 Because of its longevity and enormous information density, DNA is consi

68 only erythritol negatively affected mosquito longevity and fecundity.

69 e effects of cold exposure on H. halys adult longevity and fecundity.

70 y roles for TCER-1 in coordinating immunity, longevity and fertility, and reveal mechanisms that dist

71 rs and in comparison to historical trends in longevity and gross domestic product.

72 present an analysis of the variation in tree longevity and growth rate using tree-ring data of 3,343

73 s depends critically on the response of tree longevity and growth rates to future climate.

74 population ageing metric that reflects both longevity and health status, incorporates a comprehensiv

75 factors that mediate indirect assortment on longevity and human disease risk will help to unravel fa

76 However, how they coordinate to determine longevity and if they act via separable mechanisms is un

77 t, this tripartite system jointly determines longevity and life span.

78 In addition, meditation is linked to longevity and longer telomere length, a proposed biomark

79 We show that the thermal optima for longevity and mating success differ, suggesting temperat

80 gain insight into mechanisms associated with longevity and negligible senescence, age-related transcr

81 ibiting cellular senescence overlap with pro-longevity and oncogenes.

82 They are involved in longevity and oxidative stress resistance pathways and l

83 REST is upregulated in humans with extended longevity and represses excitation-related genes.

84 The first suggests that longevity and resistance to diseases are mediated by sha

85 life history - particularly with respect to longevity and resource allocation along an axis from ann

86 ality for major candidate genes of aging and longevity and their cohort effects.

87 nsable for dosage compensation but regulates longevity and thermotolerance.

88 nd are significantly overrepresented in anti-longevity and tumor-suppressor genes, while genes inhibi

89 ons, including flight, echolocation, extreme longevity and unique immunity.

90 b) matching by accounting for differences in longevity and various maturational events between the sp

91 apeutic strategies to promote skin allograft longevity and, hence, the survival of patients with seve

92 e autophagy, enhance proteostasis and extend longevity, and demonstrate an important role for sqst-1/

93 d intestinal UPR(ER) activation and extended longevity, and exposure to stress led to splicing and ac

94 play an important role in seed desiccation, longevity, and germination.

95 ndings reveal how lipid accumulation impacts longevity, and how aging cell metabolism can be rewired

96 ctivity, increased oxidative damage, reduced longevity, and oxidative stress-induced mutant Sod1 aggr

97 al TORC1 in cell nonautonomous regulation of longevity, and suggest TORC1 in the central nervous syst

98 elated to age at recording, future survival, longevity, and territory quality.

99 ated quality of life (HRQoL) in old age, and longevity are, however, less studied.

100 , and survival until an exceptional old age (longevity), are of interest to us all but require except

101 However, CYP6P9a does not impact the longevity as no difference was observed in the life span

102 dual species, we treat absolute and relative longevity as quantitative traits and demonstrate that th

103 show that paternal age can affect offspring longevity as strongly as maternal age does and that bree

104 carbon and places it into the atmosphere, in longevity, as aerial carbon - carbon dioxide.

105 tudy, we developed gene therapies based on 3 longevity associated genes (fibroblast growth factor 21

106 cted finding of increased constraint in many longevity-associated pathways underscores the power of o

107 n, employs this mechanism of ER hormesis for longevity assurance.

108 t by promoting mitochondrial homeostasis and longevity but restrains rates of Ig production.

109 Low-temperature exposure increased longevity, but reduced fecundity of ENA females.

110 ations vary enormously in mortality risk and longevity, but the causes of this variation remain poorl

111 ene therapy that may improve health span and longevity by addressing multiple diseases at once.

112 ing to increased CAR T cell cytotoxicity and longevity by amplifying 41BB-dependent signaling and mit

113 cal level, SIRT6 activity promotes increased longevity by regulating metabolism and DNA repair.

114 After age 105 years, longevity claims should be considered as extraordinary c

115 ally address the problems of maintenance and longevity commonly associated with the development of si

116 lier investment in reproduction, and reduced longevity, compared to forest species across all three r

117 for migration potential arising from larval longevity, competence, sinking, or swimming behavior.

118 At the global scale, growth rates and longevity covary strongly with temperature.

119 s retrieved from registers through 2018, and longevity determined by calculating the proportion of pa

120 widely used neonicotinoid pesticide, on bee longevity, development speed, and body mass.

121 f PopCluster to data from genetic studies of longevity discovers ethnicity-dependent heterogeneity in

122 ygen species in mitochondria (mtROS) and the longevity effect conferred by LIPL-4-LBP-8 signaling.

123 ranscriptional responses associated with the longevity effect, pointed to specific amino acids enrich

124 ), suggesting the action of an anti-aging or longevity effect.

125 In this review, we discuss the pro-longevity effects of targeting metabolic pathways in spe

126 ys is often sufficient to improve health and longevity even in the absence of stress.

127 chosen since this genotype displays enhanced longevity/exercise capacity and protects against cardiov

128 esponse and aging by defining a mechanism of longevity extension in C. elegans-bacterial colonization

129 eeps her healthy through the activity of pro-longevity factors, as long as she has her own sperm to u

130 Despite increased longevity, Fas DNR-engineered T cells did not undergo ab

131 in reaction norms for age at first maturity, longevity, fecundity, and maximum size.

132 nd double-deletion mutants did not differ in longevity from WT R. palustris and did not exhibit eleva

133 idence about contributors to the black-white longevity gap in Washington D.C., which can aid in the d

134 This study examined the klotho (KL) longevity gene polymorphism rs9315202 and psychopatholog

135 ocks should accelerate the identification of longevity genes and aging interventions.

136 n these processes is challenging because pro-longevity genes often enhance stress resistance.

137 , we make novel predictions of pro- and anti-longevity genes that are not currently in the GenAge dat

138 ize of a mouse, renowned for its exceptional longevity (>30 years) and remarkable resistance to cance

139 Finally, genetic correlation of the longevity GWA results with that of several disease-relat

140 Longevity has been a long-standing concern for hybrid pe

141 Most research on exceptional longevity has investigated biomedical factors associated

142 The genetics of human longevity has long been studied, and in this regard, cen

143 r, the relationship between productivity and longevity has not yet been described for trees growing u

144 The parasitism, biological cycle, emergence, longevity, head width and metatibia length of the natura

145 can be a single parameter to predict species longevities, here we measured in parallel the telomere l

146 stics for healthspan, parental lifespan, and longevity in a multivariate framework, increasing statis

147 n of DCP1 in Drosophila melanogaster confers longevity in adults, while neuronal DCP1 deficiency shor

148 rational design of strategies for promoting longevity in aging complex systems with potential applic

149 s the question of how to maximize health and longevity in an aging system at minimal cost of maintena

150 xidation to reduce lipid storage and promote longevity in Caenorhabditis elegans.

151 burden that consistently decreases cellular longevity in diploid yeast cells.

152 intestinal mitochondrial uncoupling controls longevity in Drosophila and suggest a new potential anti

153 inhibitor lithium act additively to increase longevity in Drosophila Remarkably, the triple drug comb

154 er risk of rapid HIV progression and shorter longevity in females.

155 We previously showed that tcer-1 promotes longevity in germline-less C. elegans and reproductive f

156 Here we show that extended longevity in humans is associated with a distinct transc

157 etabolic and cognitive processes that define longevity in humans.

158 oxes, provided superb catalytic activity and longevity in hydrocarbon cracking for propylene producti

159 ow that the transgenerational acquisition of longevity in jhdm-1 mutants is associated with accumulat

160 is and steer cell death, differentiation and longevity in mammalian cells.

161 ate parameters for electrode performance and longevity in models assessing the techno-economic viabil

162 orins, to understand the function of protein longevity in nuclear maintenance.

163 n of egg laying, egg hatchability, and adult longevity in P. pseudoinsulata did not differ according

164 xpression by acting directly to prolong mRNA longevity in response to ligand binding.

165 otection in naive subjects, but efficacy and longevity in target populations is relatively low.

166 te of adaptations that increase survival and longevity in the face of resource and energetic limitati

167 Whether a healthy lifestyle impacts longevity in the presence of multimorbidity is unclear.

168 t that conditions supporting only lower tree longevity in the tropical lowlands are likely to expand

169 f temperature and water availability on tree longevity in the tropics are consistent with theoretical

170 ort effector functions, differentiation, and longevity in their ever-changing microenvironments.

171 nd pit structure) relate to growth rates and longevity in two natural populations of the conifer spec

172 tions, elevated levels of polyamines promote longevity in various biological systems, including yeast

173 r of a cytoprotective response that dictates longevity induced by reduced mitochondrial function.

174 rgeting the relevant enzymes could represent longevity interventions.

175 Floral longevity is a critical component of floral display, yet

176 eral acid (1.5 M DCl in THF-d(8)/D(2)O); its longevity is correlated to destabilizing steric clash be

177 Furthermore, longevity is dynamically regulated by the excitatory-inh

178 The mechanism by which anhydrobiotic longevity is improved is unknown.

179 Longevity is increasing, and more adults are living to t

180 However, longevity is neither associated with the generation time

181 length is a universal determinant of species longevity is not known.

182 Limiting longevity is particularly beneficial in the context of z

183 ow this accumulation is regulated or impacts longevity is poorly understood.

184 Enhancing skin allograft longevity lessens the need for new allografts before opt

185 trophic lateral sclerosis) and influences on longevity (leukemia inhibitory factor, ceramides).

186 The cell scalability and potential vacuum longevity made possible with NEG materials may enable in

187 Longevity measurements indicated that P. vindemmiae bene

188 gnaling by rapamycin promotes healthspan and longevity more strongly in females than males, perhaps b

189 genous galactosylceramide supplementation on longevity, neurobehavioral parameters, neuronal cell cou

190 ups, establishing a phenotype of exceptional longevity & normal cognition versus cognitive impairment

191 The longevity observed with moderate alcohol consumption may

192 y basis via irrigation water, to explore the longevity of a soil inversion to reduce surface As.

193 rises to what extent these changes improved longevity of AAA patients.

194 prevent HIV transmission in humans and that longevity of anti-Env antibodies may be key to this prot

195 viduals increasing both social stability and longevity of associations.

196 Hence, there is limited information on the longevity of B and CD4 T cell memory, which are both imp

197 ely, these data provide new insight into the longevity of beta cell-specific CD8(+) T cell responses

198 s can directly influence the performance and longevity of biosensors.

199 multicomponent mass transfer, prolonging the longevity of both free- and dissolved-phase methane in t

200 bon electrodes is critical to maximizing the longevity of capacitive deionization (CDI) systems.

201 lated tyrosine phosphatase, which limits the longevity of germline-less animals by restricting the ac

202 cular complications threatens the health and longevity of humans throughout the world.

203 PQM-1 is required for the longevity of insulin signaling mutants, but surprisingly

204 nt for understanding pore-space clogging and longevity of iron-based PRBs.

205 The results of this study illustrate the longevity of legacy scales and how disequilibrium compou

206 provide evidence that ZmDREB2A regulates the longevity of maize seed by stimulating the production of

207 a of methods to augment the cytotoxicity and longevity of NK cells are also under clinical investigat

208 Increased longevity of patients with sickle cell disease in high-i

209 mic, questions concerning the prevalence and longevity of protective immunity have left vulnerable co

210 reaks to occur, we currently do not know the longevity of protective immunity to ZIKV after a person

211 he glycolysis pathway significantly extended longevity of SimCells due to its ability to regenerate A

212 Because of longevity of some reservoir hosts and the Ixodes tick ve

213 mantle(3,4), but key questions regarding the longevity of such sources on planetary timescales-and wh

214 physical drivers governing the intensity and longevity of summertime North Pacific marine heatwaves.

215 The nature and longevity of the antibody response to coronaviruses are

216 The nature and longevity of the antibody response to SARS-CoV-2 infecti

217 regarding the robustness, functionality, and longevity of the antibody response to the virus remain u

218 Sea slugs increase the longevity of the chloroplasts they steal from algae by l

219 hich guarantees the stable functionality and longevity of the device, which were tested under in vitr

220 ed exposure to antigen may contribute to the longevity of the HIV-1 reservoir by stimulating the clon

221 The survival, development, fecundity, and longevity of the maize weevil were compared between Bt r

222 g on the NPC-genome interaction, the extreme longevity of the NPC proteins, and NPC dysfunction in ag

223 an essential role of the endogenous TCR for longevity of the response at the price of alloreactivity

224 Here, the longevity of the T. gondii-induced chronic cachexia mode

225 tiple epigenetic effectors that maximize the longevity of the therapeutic effect, and we discuss limi

226 expression responses to VOR and examine the longevity of the transcriptional response in various cel

227 ction and soil-water depletion challenge the longevity of this carbon sink service.

228 ons and malignancy that limit the health and longevity of transplant recipients.

229 new drug classes to improve the function and longevity of transplanted grafts, while increasing the p

230 system that augments growth, maturation, and longevity of tubular intestinal enteroids.

231 nd thus, there are few studies examining the longevity of vaccine-induced immunity.

232 clear evidence of strong effect on honeybee longevity of widely-employed neonicotinoid insecticides

233 Loss of 1C enzymes increased the longevity of wild type cells.

234 studies have sought to classify genes as pro-longevity or anti-longevity using a variety of machine l

235 ut surprisingly limited impact on organismal longevity or fitness.

236 rrelations among partners for traits such as longevity or late-onset disease have been found to be co

237 -dependent role for hepatic mTORC2 in female longevity, our results demonstrate that metabolic health

238 ing protocols were optimized to recapitulate longevity outcomes typical of standard plate growth.

239 or understanding changes in human health and longevity over 157 years.

240 ative complication rates and promising graft longevity over the first decade after surgery.

241 upled with autophagy that is induced by many longevity paradigms and required for lifespan extension.

242 ent refinements may favorably affect patient longevity, particularly among high-risk subgroups.

243 s not mediated by canonical diet-restriction longevity pathways but is due to altered cellular respir

244 Furthermore, the reduced dormancy and longevity phenotypes observed in the dog1 seeds were not

245 key element whereby high Pi diet reduces fly longevity previously reported by us.

246 Another longevity promoting splicing factor, SFA-1, similarly ex

247 mechanistically characterised the conserved longevity-promoting effects of a natural anti-ageing dru

248 mline removal and the HSF-1 proteostasis and longevity-promoting somatic pathway.

249 ulation and direct age validation found that longevity records for ages 105 years and older are often

250 this engagement is that while patients value longevity, reducing symptom burden and achieving maximal

251 in oral health care due to its strength and longevity (ref. 2).

252 My lab has been studying aging and longevity regulation since 2005, but along the way we ha

253 including the mTORC1 suppressor Tsc2 and the longevity regulator Sirt1.

254 ization of intestinal HLH-30/TFEB, a key pro-longevity regulator.

255 meostatic aspects of low-temperature-induced longevity remain poorly understood.

256 lutionary mechanisms underlying variation in longevity remain unknown.

257 rial translation and morphology is causal in longevity remains uncharacterized.

258 he relationship between lipid metabolism and longevity remains unclear.

259 echanisms, i.e., swimming activity or larval longevity, resulting from a trade-off in the use of ener

260 Seed dormancy (SD) and longevity (SL) may share developmental and genetic mecha

261 res to predict the pro-longevity versus anti-longevity status of genes for two model organisms (C. el

262 rtance of evaluating healthspan in mammalian longevity studies.

263 in brains and serum, and assessing impact on longevity, subunit C storage, astrogliosis, and neuronal

264 well as other emerging topics in genetics of longevity, such as micro-ribonucleic acid (miRNA) geneti

265 e activity suppresses immunity, but promotes longevity, suggesting a tradeoff between these processes

266 survival, but no song traits were related to longevity, suggesting age-related patterns were not the

267 quired for multiple paradigms of DR-mediated longevity, suggesting conservation of mechanism.

268 such as agrin and integrin had much shorter longevity, suggesting their faster regeneration cycle.

269 arger body size, without a tradeoff in adult longevity, suggests vectorial capacities of some Mata At

270 iduals from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) data into two groups, establish

271 us by using the Chinese Longitudinal Healthy Longevity Survey (CLHLS).

272 nfined to the communal den, better predicted longevity than did metrics assessed during other stages

273 provide better reactivity, selectivity, and longevity than that made from a two-step process.

274 dysfunction is necessary for the increase in longevity that is induced by mitochondrial dysfunction.

275 ophila melanogaster strains with exceptional longevity that were obtained via multiple rounds of sele

276 at addition of exogenous spermidine promotes longevity through autophagy induction; however, these ex

277 stablishing stimulus localization, improving longevity through immune compatibility, reducing energy

278 iome interactions to improve host health and longevity through targeted microbiome therapies.

279 the studied populations, indicating a growth-longevity trade-off.

280 st, we created period life tables to examine longevity trends in Washington D.C.; second, we decompos

281 AF-16/FOXO and SKN-1/Nrf function to promote longevity under conditions of low insulin/IGF signalling

282 t to classify genes as pro-longevity or anti-longevity using a variety of machine learning algorithms

283 sion datasets as features to predict the pro-longevity versus anti-longevity status of genes for two

284 a hub for signal transduction and regulates longevity via affecting nuclear transcription.

285 sed-loop disease management, the cost, size, longevity, warm-up time, and response speed need to matc

286 Median longevity was 13.5 years (IQR 9.9-16.0).

287 Interestingly, maximum larval longevity was lowest for the most active but intermediat

288 undities and larval sizes, the median larval longevity was similar among the three species.

289 binding to oviduct cells and increase sperm longevity, we immobilized suLe(A) and incubated it with

290 ortality rates and the lowered fecundity and longevity were attributable to the down-regulation of Mp

291 ) played a major role in regulating seedbank longevity when interacted with the other SD gene(s).

292 ore green space is associated with increased longevity, which has policy implications for the nationa

293 have been optimized during the evolution of longevity, which provides new targets for anti-aging int

294 ntal restorative materials compromises their longevity, while leachable compounds from these material

295 ing by increasing fluorophore brightness and longevity, while simultaneously reducing the generation

296 tation, we find consistent decreases in tree longevity with increasing aridity, as well as a pronounc

297 ities toward a challenging goal of achieving longevity with no cancer.See related article by Timofeev

298 made to identify the genetic basis of human longevity, with only limited progress.

299 ssociated with improved health and increased longevity, with some studies suggesting that more is bet

300 cial in designing interventions that promote longevity without negative health consequences.