ライフサイエンスコーパス: loop region

1 gene in the minor arc, and the non-coding D-Loop region.

2 conserved sequence associated with the gp41 loop region.

3 the mode of action of these mutations on the loop region.

4 nal change of the Arg residue in the stromal loop region.

5 crystal structure in the conformation of the loop region.

6 t is associated with the membranotropic gp41 loop region.

7 eculiar non-Watson-Crick interactions in the loop region.

8 tein family, SRSF2 structure has a longer L3 loop region.

9 exhibits an altered conformation within this loop region.

10 elial stem cells that reside in the cervical loop region.

11 contains three pseudouridine residues in its loop region.

12 with the C5 of its adjacent 3' uracil in the loop region.

13 a single-stranded configuration within the R-loop region.

14 ail sequence and not the inverted-repeat and loop region.

15 ce is demonstrated to be predominantly in DE loop region.

16 llosteric control regulated via the Cbeta FG loop region.

17 ane space (IMS)-exposed charged unstructured loop region.

18 five Rpt subunits, most notably in its pore loop region.

19 lternative protein backbone conformations in loop regions.

20 t of the protease and are located in surface loop regions.

21 n of contacting residues located in flexible loop regions.

22 internal barcodes (iBARs) embedded in their loop regions.

23 und throughout the conformationally flexible loop regions.

24 t of conformational changes in two conserved loop regions.

25 ght to occur via the porin's surface-exposed loop regions.

26 luctuations are smaller than in the flexible loop regions.

27 docked ligand and the flexible extracellular loop regions.

28 matrix and go between its helices and in its loop regions.

29 erted differentiation of preexisting protein loop regions.

30 o influenced by substitutions in other outer loop regions.

31 accuracy of predicted contacts that involve loop regions.

32 with only some minor differences in surface loop regions.

33 that accounts for structure conservation in loop regions.

34 ate failed to detect exposed thymines in the loop regions.

35 ones often move significantly, especially in loop regions.

36 hat assembled CA is dynamic, particularly in loop regions.

37 e of transmembrane helices and intracellular loop regions.

38 We observed that loop regions 1 and 2 play an important role in the survi

39 inside neutrophils and dendritic cells, and loop regions 1 and 3 are needed for survival in macropha

40 e of the Arg(13)-Gln(14) peptide bond in the loop region, a catastrophic proteolytic event resulting

41 ace, and here we studied a role of the Ndc80 loop region, a distinct motif looping out from the coile

42 king site consists of side chains from three loop regions (AB, EF and BG) and part of the betaD stran

43 In sum, our data suggest that the loop region acts as a "hinge" around which the bulky hea

44 tant motifs within the N-terminal or central loop region affected crescent maturation and the immatur

45 n disrupts the packing of the protective cap-loop region against the active site allowing loop openin

46 inding domains) as foreign components to the loop regions allows the formation of active Mg(2+)- or Z

47 ucts that were cyclically permuted in the V1 loop region and contained an N-terminal trimerization do

48 We mutated a second aptamer (40 nt) in one loop region and incorporated pyrrolo-deoxycytidine to re

49 nique charged IgE epitope residues at the L2 loop region and on helix alpha3.

50 re generally very similar except for the A-B loop region and part of helix B (residues 15-31) which c

51 A model involving the movement of the B-C loop region and R108 between the open and closed conform

52 ors for tau exon 10, p68 binding at the stem-loop region and RBM4 interacting with the intronic splic

53 f DHFR engineered within the Met20 catalytic loop region and study the protein's structural motion at

54 tes a reciprocal communication between the W-loop region and the nucleotide binding cleft on actin.

55 t the accessible conformational space of the loop region and thus reduces the entropic cost of KID fo

56 d a diversity of mitochondrial DNA (mtDNA) D-loop region and Y chromosome SNP markers in 25 male and

57 e secondary structural elements and variable loop regions and evaluate the method's performance in na

58 bserved, such as small inversions in hairpin-loop regions and indels, which were common in intergenic

59 eractions between specific basic residues in loop regions and phosphate oxygens of the CL head group.

60 s state, such as conformationally restricted loop regions and positioning of C2 domains in close prox

61 Therefore, we hypothesize that these loop regions and the flexibility of the P domains play i

62 the presence of a 22-amino-acid N-terminal 'loop' region and its catalytic activity.

63 the alignment, with many in the important A-loop region, and others spread between the N and C lobes

64 RPV1 that are localized in the putative pore-loop region; and activation of TRPV1 by CFA1 is not excl

65 Instead, binding of a conserved loop region appears to compete with dimerization and anc

66 tween them and wild-type RpMatB was within a loop region approximately 23 A from the acetylation site

67 that the long noncoding RNA species in the D-loop region are generated by the extension of H-strand t

68 Afterward, the loop regions are compared one-to-one in accordance with

69 al beta-sheet and flanking alpha-helices and loop regions are formed.

70 h previous reports that amino acids in these loop regions are involved in differentiating AAV recepto

71 The AU element and stem-loop regions are phylogenetically conserved within dusB-

72 ions are strongly temperature-dependent, and loop regions are surprisingly mobile.

73 levels of flexibility, for example, exposed loop regions are usually more flexible than the core reg

74 luctuations in SH3, and in particular the RT loop region, are structurally diverse and are well-appro

75 na mtTyrRSs, highlight flexible terminal and loop regions as major sites for enzyme diversification,

76 and no mutations have been found within the 'loop' region as expected.

77 s, orchestrated by key residues in exofacial loop regions, as well as in membrane-spanning helices.

78 ompanied by loss of flexibility of two helix/loop regions, as well as of the C-terminal helix; (iii)

79 ulation of the channel, are located in the D-loop region at the center of the predicted dimer interfa

80 Structural analysis revealed a loop region at the N terminus as a putative acceptor sub

81 binds in an orientation that disrupts the BC-loop regions at the P450 dimer interface and results in

82 ce of Top2alpha-DNA complexes in the mtDNA D-loop region, at the sites where both ends of 7S DNA are

83 Modeling actin's D-loop region based on our 3.9 A cryoEM reconstruction sug

84 hat the SP-A lectin site and the surrounding loop region become more compact.

85 Guided by structural differences in the loop region between beta4 and beta5 strands, we identifi

86 site is composed of residues in EF4 and the loop region between EF3 and EF4, confirmed by mutagenesi

87 of the HNP family, with the exception of the loop region between the first and second beta-strands.

88 ntracellular C-terminal domain (CTD) and the loop region between the M1 and M2 helices move during ac

89 of the protein backbone of the so-called 60s loop region between the two flavodoxins.

90 effectors through (i) insertion/deletions in loop regions between alpha-helices, (ii) extensions to t

91 (betaB to betaI) beta-barrel core and large loop regions between the strands which form the capsid s

92 tranded anti-parallel beta-barrel with large loop regions between the strands.

93 We found that the N-terminal of the SNAP25 loop region binds with membrane, and this interaction in

94 anism that yields functional RNAs from miRNA loop regions, broadening the repertoire of Argonaute-dep

95 tion properties of the H5 hemagglutinin stem loop region by site-directed mutagenesis.

96 Engineering of these loop regions can alter protein stability, substrate bind

97 ut disregard the length details of helix and loop regions, can improve the performance of structure p

98 The Ser(36) is located in a loop region close to the entrance of the proposed substr

99 ls significant structural differences in the loop regions compared with other TIR domain structures.

100 a stem, with fluorophore/quencher pair and a loop region complementary to the desired DNA.

101 A unique loop region comprised of residues (536)Y-N-G-H-P-P(541),

102 conformational difference in the C-terminal loop region (comprising residues 170-176 and 195-206).

103 Here, we have identified the flexible loop region connecting the bulky enzymatically active he

104 peptide) corresponding to the extracellular loop region connecting the S5 and S6 segments of the HER

105 fy an intrinsically unstructured cytoplasmic loop region connecting transmembrane helices 5 and 6 (CL

106 y MpPR-1 requires the presence of a flexible loop region containing aromatic amino acids, the caveoli

107 ons of the RNA are important for activation, loop regions contribute as well.

108 s, including the sequences flanking the stem-loop region, contributed to high affinity EWS binding an

109 tyrosine and phenylalanine in the catalytic loop region could serve as a signature residue to reliab

110 easoned that lasso peptides cleaved in their loop region could serve as building blocks for catenanes

111 loops connecting the TMHs, suggesting these loop regions could be involved in gating H(+) release to

112 on of conformational flexibility in terminal loop regions could explain the presence of multiple homo

113 Here, using select loop-region Cys from the single cytoplasmic loop of subu

114 POLG1 continued to be down-regulated, the D-loop region damaged, and the CpG islands at the regulato

115 tify amino acids within the N terminus and a loop region distal to the nucleotide binding pocket of T

116 Mobile loop regions distal to the active site exhibit significa

117 cular basis for the epitope at the disulfide loop region (DLR) of the principal immunodominant domain

118 s pocket as well as the second extracellular loop region (ECL2).

119 ectively incorporated into the extracellular loop regions (ECLs) of GCGR and GLP-1R, two members of c

120 As the loop regions engaged in RNA tertiary interactions, the l

121 The loop region extended from the compact core in the crysta

122 5 loop and syx-1, suggesting that the SNAP25 loop region facilitates SNARE-complex assembly through p

123 Thus, the AP site in any loop region facilitates the formation of the propeller l

124 The third inter-repeat loop region (Finger 3 loop) is flexible and may act as a

125 residue Tyr322 became disordered as did the loop region flanking it.

126 whereas the D0 domain of the KIR3DLs binds a loop region flanking the alpha1 helix of the HLA molecul

127 ement for negatively charged residues in the loop regions for divalent ion binding.

128 releasing the Mg(2+) cofactor highlights two loop regions for which fragmentation increases upon UVPD

129 Helix 69 (H69) is a 19-nt stem-loop region from the large subunit ribosomal RNA.

130 l CTLD-containing proteins, including a long loop region hydrophobic core associated with calcium-dep

131 urthermore, cross-linking identifies another loop region (i.e., the C'D-loop) that undergoes a remote

132 n vitro Furthermore, we identified a surface loop region in AFF4-CHD as a substrate for the P-TEFb ki

133 icates that phosphorylation of an N-terminal loop region in APC1 is sufficient for binding and activa

134 ervations are consistent with a role for the loop region in cis-CaaD specificity and catalysis, but t

135 appreciated role for the kinase beta3-alphaC loop region in controlling specificity.

136 s from the conformation of the corresponding loop region in crystal structures of free SNase.

137 of RuvC, highlighting a unique role of this loop region in Fpr-HJ interaction.

138 Furthermore, the shorter loop region in Mtb DsbF results in a more solvent-expose

139 idation of the model and conformation of the loop region in NKR-P1C were addressed using ion-mobility

140 ate the role of key residues and the 116-128 loop region in substrate binding and turnover.

141 ecifically interacted with the variable-stem-loop region in the 3' NTR and domain IIId of the HCV-IRE

142 Furthermore, a highly acidic loop region in the ARC2 domain and basic patches in the

143 ng to MMRN2 is dependent on a predicted long-loop region in the C-type lectin domain and is abrogated

144 is report, we have identified the MT-LOOP, a loop region in the catalytic domain of MT1-MMP ((163)PYA

145 tability is observed upon modifications of a loop region in the enzyme acylphosphatase and is achieve

146 requires replacement of the three amino acid loop region in the fingers domain of Tgo-Pol with a long

147 s, and it was revealed that the more rigid P-loop region in the G2032R-mutated ROS1 was primarily res

148 nterface but, rather, triggers movement of a loop region in the propeptide that modulates access to t

149 n the proportion of IgG specific for certain loop regions in AMA1 surrounding the binding site of RON

150 ltimately unveiling the central roles of key loop regions in influencing substrate binding and turnov

151 F causes a structural stabilization of three loop regions in the mature part, possibly through a dire

152 re formed through large, rare motions of the loop regions in trypsin.

153 We conclude that the loop-regions in subunits a and c that are implicated in

154 ences between maize and barley LTP in the AB loop region, in residues at the base of the hydrophobic

155 Meanwhile, the motion of Spy's flexible loop region increases, allowing for better interaction w

156 tenuate microsecond-timescale motions of the loop regions, indicating that preorganization of the met

157 Mutations that restrain the terminal loop region inhibit Drosha processing of primary microRN

158 hange of up to 38 A in the N terminus, and a loop region involving Tyr(38)-Tyr(39).

159 We therefore propose that the MT-LOOP region is an interface for molecular interactions t

160 i has the following unique features: (i) the loop region is closed by a Watson-Crick base pair betwee

161 In the pH 3.5 structure, the EF helix-loop region is completely disordered.

162 We conclude that a flexible terminal loop region is critical for microRNA processing.

163 ts of a number of short stem-loops where the loop region is disordered.

164 tochondrial 5-methylcytosine levels in the D-loop region is found in the substantia nigra in Parkinso

165 e of the polypeptide sequence, another hinge-loop region is observed between strands beta7 and beta8

166 We also show that this Esa1 Tudor domain loop region is positioned close to nucleosomal DNA and t

167 shing ligand residue approximation with this loop region is unique among family members and may help

168 s appear not only in cases where the Pro-Xaa loop-region is altered, but also when seemingly subtle a

169 dases including spinach glycolate oxidase, a loop region, known as loop 4, is completely visible when

170 Structural comparison highlighted two loop regions, L3 and L4, as potential sites of interacti

171 o-acid sequence within the substrate-binding loop regions lead to different preferred binding modes.

172 The loop region linking the beta-strands (loop 4) presents r

173 dition, the enzymatic digestion at the Lys28 loop region linking the two beta-sheets in Abeta fibrils

174 Each monomer has flexible loop regions linking the core alpha-beta-alpha sandwich

175 und in the sequence PNAIG) within a flexible loop region (loop 2) within the central core region.

176 l and mitochondrial dynamins, however, where loop regions manage membrane recruitment.

177 We also observe that the loop regions may exhibit unique flexibility, especially

178 a cluster of RP mutations in the intradiscal loop region, mediate dose-dependent rhodopsin destabiliz

179 Loop region mutations lead to a wide range of topologies

180 A loop region near the catalytic Walker B motif of Orc1 di

181 rmational behavior of the 5' half of the H69 loop region, observed as broadening of C1914 non-exchang

182 is region are removed, translocation of this loop region occurs largely by a YidC- and Sec-independen

183 e repair of a DNA base lesion located in the loop region of a CAG repeat hairpin can remove the hairp

184 substitution (Cys227Ser) in the predicted E-loop region of aquaporin 11, is responsible for the sjds

185 ely, synthetic peptides corresponding to the loop region of Bcl-2 were sufficient to potently inhibit

186 We found that an 8-oxoguanine located in the loop region of CAG hairpins of varying sizes was removed

187 gnificant changes in the dynamics of the F-G loop region of CBD2 that merit further characterization

188 (FHA) interaction motifs in an unstructured loop region of Cdc45, which is phosphorylated by Rad53 i

189 F-phenotypic mutation, E217G, located in the loop region of CFTR's membrane-spanning domain.

190 These in silico studies showed that the B-C loop region of CYP2C9 moves away from the heme to a posi

191 se antibodies to the highly conserved fusion loop region of E domain II.

192 The beta2-alpha2 loop region of endogenous prion protein, PrP(C), has bee

193 The loop region of gp41 is also known as principal immunodom

194 For example, MAbs against the external loop region of gp41 made the most effective ITs against

195 roduction of truncated versions removing the loop region of gp41 or the utilization of nonphysiologic

196 The highly conserved stem loop region of hemagglutinin has been shown to undergo c

197 teristic fragment of the mitochondrial DNA D-loop region of horse onto the surface of magnetic microc

198 Here, we show that the terminal loop region of human primary microRNA transcripts is an

199 Emission maximum of NBD-labeled loop region of KvAP-VSD (residues 110-117) suggests a si

200 nd that Lin28 selectively binds the terminal loop region of let-7 precursors in vitro and that the lo

201 antibody that specifically recognizes the MT-LOOP region of MT1-MMP (LOOPAb) inhibited MT1-MMP functi

202 n enzyme, and the damage to the displacement loop region of mtDNA (D-loop) were analyzed in the retin

203 Mapping of Top1mt sites in the regulatory D-loop region of mtDNA in mitochondria revealed the presen

204 l 5-methylcytosine levels are found in the D-loop region of mtDNA in the entorhinal cortex in brain s

205 peptide constructs of the thrombin-sensitive loop region of murine anticoagulant protein S.

206 tive, including residues in the beta2-alpha2 loop region of PrP.

207 Several studies imply that the loop region of SNAP25 plays important roles in SNARE-com

208 ious studies have implicated the beta6/beta7 loop region of SrtA in LPXTG recognition but have not sy

209 addition to the previously identified hinge-loop region of the 3D domain-swapped dimer, which reside

210 Replacing human PDE5 residues in the M-loop region of the binding site for the PDE5-selective i

211 ent DNAzyme, and a sequence identical to the loop region of the coadded hairpin structure.

212 The loop region of the complex enables its bent conformation

213 Together, these results suggest that the loop region of the fingers domain may play a critical ro

214 d through insertion of TagRFP in a conserved loop region of the Galpha subunits.

215 d significantly, and we found changes in the loop region of the heavy chain's constant domain; this c

216 idence of a capping structure within the top loop region of the i-motif.

217 hosphorylation of Thr(383)/Thr(387) in the T-loop region of the kinase domain an event that is a prer

218 E329 lies within the glycine-rich loop region of the kinase.

219 version and have found that the beta2-alpha2 loop region of the mouse prion protein (residues 165-175

220 GC-1alpha was specifically enriched at the D-loop region of the mtDNA, which contains the promoters f

221 conclude that 'rigidity' in the beta2-alpha2 loop region of the normal conformer of PrP has less effe

222 ptide from 1 protofilament connecting to the loop region of the peptide in the opposite protofilament

223 n 164 (mouse numbering), in the beta2-alpha2 loop region of the prion protein, to attempt to decipher

224 hT insert into the channel that forms in the loop region of the protofibril, sandwiched between two s

225 increase the susceptibility of the EF helix-loop region of the TTR B subunit to undergo conformation

226 e of restricted/bound water molecules in the loop region of the VSD in micelles and membranes.

227 y the direct association of an intracellular loop region of these proteins with Ca2+-CaM.

228 ing domain (aa 129-150) of the intracellular loop region of this connexin exhibited a high affinity,

229 previous work demonstrated that the 3' stem-loop region of U6atac snRNA contains a U12-dependent spl

230 es of chimeras in which putative DNA binding loop regions of APOBEC3G were replaced with the correspo

231 Deletion of the flexible loop regions of Bcl-2 and Bcl-X(L), which are located be

232 tions coincided with predicted extracellular loop regions of both P2 and P5.

233 sequences derived from various intracellular loop regions of G protein-coupled receptors (GPCRs) are

234 ify amino acid residues, predicted to lie in loop regions of GerVB on the exterior aspect of the memb

235 nformational changes induced by A1120 in two loop regions of hRBP4.

236 We also showed that substitutions in the loop regions of iMs give a distinctly different kinetic

237 between the amino acid sequences in flexible loop regions of native states and the corresponding expe

238 re small regulatory RNAs processed from stem-loop regions of primary transcripts (pri-miRNAs), with t

239 structural differences, particularly in the loop regions of the GI.7 P domain, altering its surface

240 old, despite substantial movement of several loop regions of the mutant, and, therefore, represents a

241 rmation including the functionally important loop regions of the protein structures.

242 s of which corresponded to the more flexible loop regions of the proteins.

243 decrease in secondary structure within stem-loop regions of these transcripts in mta mutant plants.

244 id substitutions lie in two highly conserved loop regions of uS12 with known roles in maintaining the

245 d by CAP-Gly varies, particularly around its loop regions, permitting its interaction with multiple b

246 ies provide strong evidence that the size of loop regions plays a critical role in determining the mo

247 in loss of conformational plasticity of the loop regions, potentially pre-organizing them for additi

248 istidine exchange variants within a flexible loop region provide compelling evidence that the glycine

249 ggest that the number of cysteines in the TM loop region readily distinguishes between covalent and n

250 n also bound recombinant EDA within the C-C' loop region recognized by the alpha(9)beta(1) integrin.

251 tended by a secondary motif formed by unique loop regions, recognizing 6-O-sulfated galactose dictate

252 erized by short runs of guanine separated by loop regions, regardless of the nature of the loop seque

253 at the primary structure of the beta2-alpha2 loop region (residues 165-175) in mammalian prion protei

254 A loop region (residues 243-266) near the purine base beco

255 pth analysis of phosphorylation within the T-loop region (residues 366-406).

256 m wet-lab experiments in which the LEL delta-loop region showed a pronounced flexibility.

257 in distinct ways through diversification of loop region structure and composition in EC2 and EC3, wh

258 PS1) N-terminus and in the large hydrophilic loop region suggest that the enzymatic function of PS1/g

259 gand-associated conformational change in the loop region surrounding the lectin site, one not previou

260 The gp41 disulfide loop region switches from a soluble state to a membrane-

261 on partial metal ion saturation of the intra-loop region, Syt1 adopts a dynamic, partially membrane-b

262 Although the dynamic loop region targeted by these compounds presents challen

263 zinc finger and an approximately 40-residue loop region that appear to play roles in protein stabili

264 y site-directed mutagenesis, we identified a loop region that connects the A-box and B-box domains of

265 osylation of Srr2 and identified a conserved loop region that is crucial for acceptor substrate bindi

266 nds and multiple conformations of a flexible loop region that is thought to be involved in lipid bind

267 how that these mutations are in a loop-helix-loop region that positions the key residues of the catal

268 from those of other parvoviruses in surface loop regions that control receptor binding, tissue tropi

269 Loop regions that exhibit the most conformational flexib

270 flexibility within the hydrophobic core and loop regions that orient the DNA binding helices.

271 Several mobile loop regions that restrict access to the cofactor-bindin

272 slate to extensive structural changes in the loop regions that significantly alter the surface topogr

273 )N spin-relaxation NMR spectroscopy of three loop regions that surround the active site and contain f

274 geting porcine mitochondrial displacement (D-loop) region that yielded an unique amplicon of 712 base

275 sites can be found within Envelope variable loops, regions that play an essential role in HIV pathog

276 With deletions or mutations of the loop region, the lateral KT-MT attachment occurred norma

277 tamer engineering that involves removing one loop region, then systematically modifying the number of

278 The Ndc80 loop region, therefore, has an important role in the con

279 tructure of the Ad14P1 fiber knob in the F-G loop region, this did not significantly change the fiber

280 bility and/or altered structure in the hinge-loop region to accommodate the large conformational chan

281 190 act in concert with the flexible EF3/EF4 loop region to effectively form different peptide-bindin

282 tudies underscore the importance of the stem loop region to HA function and suggest potential sites f

283 an atypical isoleucine residue in a flexible loop region to the bulkier or charged residues tyrosine,

284 conserved alpha-helix for COI1 docking and a loop region to trap the hormone in its binding pocket.

285 ositioning of the functionally important "BB-loop" region to a location more typical for TIR domains.

286 NMR structural ensembles are found in three loop regions, two of which undergo motions that are of f

287 ically engineered to create and attack bulge-loop regions upon hybridization to target RNA.

288 licing regulators interacting with this stem-loop region using an RNA affinity pulldown-coupled mass

289 The Ndc80 loop region was required for Ndc80-Dam1 interaction and

290 d that RCC1 uses a conformationally flexible loop region we have termed the switchback loop in additi

291 rm the oxyanion hole and movement of the lid loop region when the active site is occupied.

292 tiary structure tend to be least accurate in loop regions, where non-canonical pairs are important fo

293 dimer-dimer interaction involves a variable loop region, which differs in length and sequence from t

294 In contrast, the H69 UUU loop region, which lacks Psi modifications, is less orga

295 1I changed the flexibility of the 110-to-115 loop region, which may affect deoxynucleoside triphospha

296 laced internal 6 bp RNA stems that supported loop regions with 6 base-triple hybrid stems using fluor

297 The beta2-alpha2 loop region within PrPC varies substantially between spe

298 Two studies now demonstrate that a conserved loop region within the extended coiled-coil of Ndc80 pla

299 Furthermore, loop regions within junctions are high in adenine but lo

300 In class (B2), we found changes in the same loop region without the overall distortion.