ライフサイエンスコーパス: loose

1 Her stools were variably loose.

2 orrelation between structure and function is loose.

3 crossover trial of tight (80-110 mg/dL) vs. loose (120-150 mg/dL) glycemic control in patients with

4 recision of blastx-based annotations without loosing accuracy.

5 natural dNTPs, due to their low fidelity and loose active site, but are limited by poor processivity

6 Sociality based on loose aggregation is followed by a second shift to stabl

7 Loose aggregations of fishes, or shoals, are a basal soc

8 These studies demonstrate a loose allosteric coupling of the agonist-binding site an

9 to the RASopathy, Noonan-like syndrome with loose anagen hair (NS/LAH).

10 sease known as the Noonan-like syndrome with loose anagen hair.

11 -a-string structures that combine regions of loose and compact fiber independently of the characteris

12 tain different types of aggregates including loose and dense aggregates, as well as hydrodynamically

13 the self-perception of teeth/gum health and loose and lost teeth were valid to predict severe period

14 ough long distances, the fine combination of loose and specific kinase/regulator interactions, and ma

15 w some limits were circumvented, and compare loose and tight limits.

16 s revealed spontaneous transitions between a loose and tightly zippered state at the SNARE complex C

17 These results suggested that the loose and transient interaction between T20 and T1144 ma

18 en mixed in solution, T20 and T1144 showed a loose and transient interaction, with a moderate 10% alp

19 properties, such as higher shear strength in loose and wet forms.

20 es, together with simulations, emphasise the loose architecture of the AMPAR extracellular region (EC

21 unit length that is consistent with a rather loose arrangement of nucleosomes.

22 ansfer quenching is mediated by a relatively loose arrangement.

23 The relatively loose (as seen in solution) tetramer interface is assemb

24 ed upon Brefeldin A exposition, indicating a loose association with Golgi membranes.

25 ts indicate that human pol delta maintains a loose association with PCNA while replicating DNA.

26 lls with low pH or denaturants, suggesting a loose association with the cell wall or cell surface.

27 rack contact points of alternating tight and loose attachment convert domain rotations to unidirectio

28 function, and poor perfusion accompanied by loose attachment of pericytes.

29 h, which allows robust distinction between a loose attachment with low tension and a strong attachmen

30 oximately 7 degrees , resulting in tight and loose axial subunit packing in the rod and hook, respect

31 aining different surface functionalities and loose beads such as titania and zirconia for phosphopept

32 to move effectively from a fluid through the loose bed surface layer which fluidizes easily to the we

33 e Aalpha406-483 fragment identified a second loose beta-hairpin formed by residues 459-476, yielding

34 their low surface energy suggests relatively loose binding of H2O on the internal and external surfac

35 uld be modeled in a system involving initial loose binding of inhibitor, followed by a slow step lead

36 8-12 to form an inverted V, facilitated by a loose binding of TM1 and TM7 to their respective bundles

37 pre-exponential factor, probably due to the loose binding of X inside the cage.

38 through subtle conformational changes into a loose binding site in which hydrolysis occurs faster.

39 b-Angstrom gradual changes between tight and loose binding site structures dramatically alter the hyd

40 restoration role of resveratrol toward some "loose-binding" substrates of SIRT1, and has significant

41 rational-coupled excited-state relaxation (a loose-bolt effect).

42 We applied this approach to corroborate the "loose-bolt" postulate for the reaction mechanism in Wulf

43 Transmission initially involved a "loose" bottleneck, which became strongly selective after

44 ignificantly higher (p = 0.023) and rates of loose bowel movements tended to be lower (p = 0.053) in

45 nd application of steroid ointments improved loose bowels and skin lesions as well as laboratory data

46 otofilaments to associate into long straight loose bundles and/or sheets at both pH 6.5 and pH 7.5, w

47 olute size and introduces what seems to be a loose but clade-wide mammalian constraint on head shape.

48 , showing that transmission is governed by a loose, but highly variable, transmission bottleneck whos

49 and CD8, whereas CD2(+) subsets can gain or loose CD8.

50 ntricate interplay may enhance the spread of loose cell ensembles in pathophysiological conditions su

51 most common ALCB management practice is the loose cell system, in which cocooned bees are removed fr

52 DVL prevents NEK2-controlled dissolution of loose centrosomal linker and subsequent centrosomal sepa

53 dense clustering of hydrogen bonds within a loose chemical network.

54 ly clustered 26S proteasomes surrounded by a loose cloud of Cdc48.

55 greater transcriptional variation with only loose clustering of strains with different phenotypes.

56 experiments, we observed CART expression in loose clusters of spinocerebellar mossy fibers in the mo

57 acting on the transmembrane segment produce loose clusters, while cytoplasmic protein interactions m

58 n chlorine additions, and behave as soft (or loose) clusters in solution.

59 mble a loosely coiled NC-like structure; the loose coil can be condensed by binding of the viral matr

60 that cells move on planar surfaces and in a loose collagen matrix using prominent, curved planar pro

61 yosin II signaling on a 2D substrate or in a loose collagen type I matrix.

62 Sepsis is not a monolithic disease, but a loose collection of symptoms with diverse outcomes.

63 AKI is not a single disease but rather a loose collection of syndromes as diverse as sepsis, card

64 ervations have shown that some asteroids are loose collections of rubble rather than solid bodies.

65 h as the beta(2)AR, previously shown to form loose complexes with beta-arrestin ("class A") promote a

66 th muscle cell-rich fibrous tissue (12%) and loose connective tissue (9%).

67 5-4.0 mm) contained valve tissue composed of loose connective tissue (collagen and elastic fibers) wi

68 haly, digital abnormalities, hypospadias and loose connective tissue) and resemble one another facial

69 found sparsely in the stroma of subcutaneous loose connective tissues.

70 ith that from LHCI to the PSI core, suggests loose connectivity between LHCII and PSI-LHCI.

71 Comparison of these loops revealed a loose consensus sequence.

72 contact with the neural tube, and they never loose contact with the neural ectoderm.

73 ose was under tight control as compared with loose control (3.2 +/- 0.6 vs. 2.4 + 0.4, p = .02 [whole

74 ction in pi overlap (as these two p-orbitals loose coplanar state) resulting in a very weak -M effect

75 Scattered genes with relatively loose correlations should be excluded from the clusters.

76 prevalent glutamate release site, suggesting loose coupling between the two.

77 oceeds with millisecond speed, that there is loose coupling between this initial step and activation

78 hrough integration of local activity inputs, loose couplings with neighboring cortical columns, and g

79 toothache; broken/missing fillings or teeth; loose, crooked, or stained teeth; and/or bleeding gums),

80 nd 11.7 kcps/MBq at the center for tight and loose cuts, respectively, increased to 8.8 and 13.9 kcps

81 ing rate of 19.5 and 22.7 kcps for tight and loose cuts, respectively, was achieved for an activity c

82 rgy and timing cuts-400-650 keV and 7 ns-and loose cuts-350-700 keV and 10 ns.

83 For the purposes of this review, a loose definition of cross-coupling is utilized; all reac

84 se skin for salt rejection and (ii) a fairly loose dense skin for emulsified oil particle rejection.

85 The bacteria associated with loose deposits and pipe wall biofilm that accumulated in

86 cteria, and the contributions of bacteria in loose deposits and pipe wall biofilm were comparable.

87 The accumulation of loose deposits and the aging process create variable mic

88 ter (Betaproteobacteriales) in the water and loose deposits during summer.

89 ose deposits were dependent on the amount of loose deposits locally.

90 Moreover, loose deposits protect the associated bacteria from disi

91 ess create variable microenvironments inside loose deposits structures for bacteria to grow.

92 system; however, the communities present in loose deposits were dependent on the amount of loose dep

93 sociated bacteria (from suspended solids and loose deposits) have long been neglected.

94 teria within the phases of suspended solids, loose deposits, and pipe wall biofilm were similar in ph

95 Depending on the amount of loose deposits, its contribution can be 7-fold higher th

96 er, pipe wall biofilm, suspended solids, and loose deposits, were quantified and identified by adenos

97 phases, especially the bacteria harbored by loose deposits.

98 that four Ptch1 protomers are organized as a loose dimer of dimers.

99 synthase dimer arrays, which differ from the loose dimer rows in all other organisms observed so far.

100 nkled and the dermis is thin and composed of loose, disorganized, and fragmented collagen fibrils.

101 the number of tethering SNARE complexes upon loose docking and the size of the interacting membrane p

102 Tight Hox and the first loose ecdysozoan ParaHox homeobox clusters are identifie

103 d macrophages were present in the linear and loose ECM of inflamed colons and polarized to the M1 phe

104 , we find that both types of apparatuses can loose elements of their cytoplasmic region, which may th

105 n the absence of BBG, these junctions become loose, enabling the intestinal flora to trigger a consti

106 d patient presented with lymphedema, protein loosing enteropathy, and sclerosing cholangitis and was

107 e findings of microcysts, fingerprint lines, loose epithelium, and/or faint scars.

108 subunit in these cells converts them from a "loose" epithelium, characterized by low expression of E-

109 l fluoride with azide ion proceeds through a loose (exploded) transition-state (TS) structure.

110 erence 1.07 CFUs; P = .001), subjects with a loose face mask (difference 0.67 CFUs; P = .034), and su

111 on beta1 or beta2 integrins, was observed in loose fibronectin and collagen regions, whereas T cells

112 nism in human T-lymphocyte CEM cell extracts loosing first the AB moiety, followed by the ACB group.

113 because of a more open NBP but because of a loose fit of substrates bound in the catalytic centers.

114 ead and wearing various face masks (no mask, loose fitting surgical mask, tight-fitting surgical mask

115 The spore is surrounded by an exosporium, a loose-fitting membrane composed of proteins and carbohyd

116 of WOX3 function in M. truncatula leads to a loose-flower (lfl) phenotype, where defects are observed

117 ution structure of PDEgamma, which reveals a loose fold with transient structural features resembling

118 polymeric structure of chromatin - from the loose folds of whole chromosomes to the detailed loops o

119 hybrid bound in the active center, which is loose for RNAP III relative to other RNAPs.

120 the dense form of the light stripes and the loose form of the dark stripes.

121 dense iridophores but down-regulated in the loose form.

122 spirasome)-a major 'tight' form and a minor 'loose' form (resolved at the resolution of 5.8 A and 6.7

123 w modality for physicians to address chronic loose, frequent stools with FI in patients with CMI in t

124 hronic mesenteric ischemia (CMI) for chronic loose, frequent, and urgent stools.

125 complex, but did not affect formation of the loose FXa-TFPI complex.

126 However, the loose GAC particles and slow kinetics of this primitive

127 It reveals a predominant contribution of loose H bonds even for fully hydrated states, irrespecti

128 homologs (for example, XylE), GlcP(Se) has a loose H(+)/sugar coupling.

129 nd acceptor, and results show the need of a "loose" H-bond acceptor for improved adduct stability.

130 a low tolerance of deviant behavior) versus loose (have weak social norms and a high tolerance of de

131 ure, the long PEVK peptide retains residual, loose helical configurations.

132 Such a loose hemispheric specialization for language permits th

133 he simulations show chromonic columns with a loose hexagonal packing and an intercolumn distance of 2

134 mational dynamic profile, making hinges more loose (i.e., softening the hinges), thus impairing the a

135 However, these associations were loose; individuals did not reassociate in highly stable

136 as CXCL12-expressing stromal cells, and only loose infiltrates of T cells are present.

137 y establish "head-to-shoulder" contacts with loose interactions between each other.

138 ross tight subunit interfaces but not at the loose interfaces, indicating that DNA-binding is governe

139 inhibits GluA2Q(flip) by forming an initial, loose intermediate that is partially conducting; however

140 vely weak (due to curved pai-conjugation and loose intermolecular contacts) and are on the same order

141 rom intrauterine arrest of compaction of the loose interwoven meshwork of the fetal myocardial primor

142 iation into effector cells; these cells form loose, intravascular clusters of motile cells that coale

143 ng the initial state of quenching, viz., the loose ion pair and the exciplex, based on the time-resol

144 ere interpreted in terms of the tight versus loose ion pairing in RTILs.

145 Furthermore, we observed that Numb looses its characteristic membrane localization in fibro

146 proaches the cloaca but the tip subsequently looses its integrity.

147 e selectivity filter together as a unit in a loose "knock-on" mechanism of permeation in both inward

148 vel folding pathway based on the idea that a loose knot forms at a terminus and slides to its native

149 We show the occurrence of both tight and loose knots, reconciling previous contradictory results

150 rough three conformational stages designated loose (L), tight (T), and open (O) in a concerted fashio

151 The network constructed from these loose leader-follower relations is hierarchical, and the

152 Such loose linkage between the alphaI and betaI is attributed

153 t diarrhea or 1-2 vomiting episodes plus 1-2 loose/liquid stools within 24 hours).

154 "traditional" diarrhea case definition (>/=3 loose/liquid stools within 24 hours).

155 nds is from the intrinsic fluctuation of the loose loops flanking the cofactor at the function site.

156 ely redundant for motility and chemotaxis in loose matrices.

157 contexts, including locomotion in fluids and loose media, impact and penetration problems, and geospa

158 one floccular biofilm, consisting of small, loose, microbial aggregates, and one granular biofilm, f

159 ting of mmu-let-7a duplex-bulges stabilizes "loose" miRNA:mRNA target associations and functions to e

160 minority member of communities in the outer (loose) mucus layer, in the cecum and colon, starting at

161 utant (K1646R) induced aberrant bundling and loose network interconnections of the keratin filaments.

162 y, suggesting that these two pathways form a loose network involved in polarized cell migratory movem

163 ch other due to myosin activity, producing a loose network that can be subsequently severely distorte

164 He reported having loose, nonbloody stools.

165 The results show a loose nucleosome array on the Nanog gene promoter in und

166 exhibiting secondary structure elements with loose or absent tertiary contacts, represent important i

167 Pressureless sintering of loose or compacted granular bodies at elevated temperatu

168 lectivities are proposed to be the result of loose or tight cation-dienolate ion pairs.

169 Patients with diarrhea, defined as loose or watery stool, and two or more Clostridium diffi

170 was caregiver-reported child diarrhoea (>=3 loose or watery stools in a 24-h period [WHO criteria])

171 ent risk factors in women are advancing age, loose or watery stools, more than 21 stools per week, mu

172 Independent risk factors in men are age, loose or watery stools, poor self-rated health, and urin

173 IBS symptoms, bloating, abdominal pain, and loose or watery stools.

174 forms large networks that in colon build the loose outer mucous layer that provides the habitat for t

175 ucture of randomly close-packed and randomly loose-packed sediments is determined by the well-known s

176 luminates various data, including the random-loose-packed state.

177 ellular domain beta-sandwich cores, and that loose packing contributes to their ability to rapidly sw

178 approaches in frictional systems the random loose packing limit, varphiRLP = 0.55.

179 Loose packing of hydrophobic cores is not infrequent in

180 We propose that loose packing of the hydrophobic beta-core developed as

181 gand-gated ion channels are characterized by loose packing of their extracellular domain beta-sandwic

182 structure of the mature fibrils demonstrate loose packing with ~1 peptide per 4.75 Abeta-sheet repea

183 that the loosest way to pack spheres (random loose packing) gives a density of approximately 55 per c

184 study may offer direct evidence for adhesive loose packings comprising dry small particles, as proven

185 kings that significantly deviate from random loose packings for hard spheres.

186 density, are quite consistent with adhesive loose packings that significantly deviate from random lo

187 ring, spanning contiguous small domains, and loose pairing, consisting of single larger domains.

188 of indistinct tight junctions, and areas of loose paracellular spaces.

189 s, did not form self-supporting gels and had loose particle arrangements.

190 the association of pyrethroid residues with loose particles in runoff water from concrete surfaces a

191 ponge-wipe method to collect and analyze the loose particles on concrete.

192 The importance of loose particles should be considered when developing pra

193 packing fraction is increased sufficiently, loose particulates jam to form a rigid solid in which th

194 Here, we use dual perforated/whole-cell and loose patch clamp on isolated OHCs to sequentially recor

195 This employed a loose patch clamp technique which examined ionic current

196 Loose patch photolysis allows the measurement of transme

197 In addition, loose patch photolysis revealed that the influx of Ca(2+

198 The novel loose patch photolysis technique allowed the dissection

199 The developed loose patch photolysis technique can provide striking ne

200 from excitation at apical, middle, and basal loose patch sites before and after perforated patch rupt

201 equency tuning and ITD tuning during in vivo loose-patch (juxtacellular) recordings from principal ne

202 intracellular recordings and a custom-built loose-patch amplifier, we have recorded unitary granule

203 Here, by combining in vivo loose-patch and whole-cell recordings, we found that com

204 I(Na)) activation and inactivation in intact loose-patch clamped murine skeletal muscle fibres subjec

205 Loose-patch electrophysiological recordings of SCN neuro

206 differentiation during cochlear maturation, loose-patch extracellular recordings were made from ANF

207 rve fiber firing rate was investigated using loose-patch nerve fiber recordings in the acutely excise

208 The spiking response, measured with loose-patch recording, adapted despite essentially no ga

209 orescent protein (RFP), followed by targeted loose-patch recordings and two-photon imaging of calcium

210 In vitro, loose-patch recordings from RTN neurons show that P2 rec

211 Loose-patch recordings in the hindbrain and spinal cord

212 Simultaneous cell-attached loose-patch recordings of Na(+) currents on each membran

213 Patch-clamp and loose-patch recordings revealed severely affected inhibi

214 Finally, whole-cell and loose-patch recordings were also performed on slices fro

215 Loose-patch recordings were used to demonstrate for all

216 Using a combination of in vivo loose-patch recordings, iontophoretic drug application,

217 Using in vivo loose-patch recordings, we found in excitatory neurons i

218 tary whisking and object touch, we performed loose-patch single-unit recordings and extracellular rec

219 ways be an ideal transition state analog for loose phosphoryl transfer transition states.

220 m, clear prism (incorporated into glasses or loose prism in the office), iseikonic manipulation (usin

221 Spirorbid tubes are comprised of a loose prismatic fabric of calcite crystals.

222 Microcompartments are loose protein cages that encapsulate enzymes for particu

223 eal that target scanning is mediated through loose protein-nucleic acid interactions, allowing Ago to

224 e unbound form of the SAM-II riboswitch is a loose pseudoknot structure that periodically visits conf

225 tosensitive if the reaction pathway involves loose radical ion pair states.

226 ategy to target 50-metre-diameter patches of loose regolith with grain sizes smaller than two centime

227 Subsequent pilot-level trials using 1kD, loose reverse osmosis (LRO) and reverse osmosis (RO) spi

228 ic assemblies - a flexuous, helical rod or a loose ribonucleoprotein.

229 ted experimental and archaeological samples, loose samples from the same locations and resin control

230 d to guide tight-seal whole-cell somatic and loose-seal cell-attached axonal/dendritic patch-clamp re

231 presentations in L5 of S1 with juxtacellular loose-seal patch recordings of optogenetically identifie

232 st of the current analytical methods rely on loose sediment samples lacking spatial and temporal reso

233 ripts due in part to direct recognition of a loose sequence motif.

234 temporal input patterns tend to fire in some loose, sequential manner that is reminiscent of experime

235 ix to improve the mechanical strength of the loose soil and simultaneously mitigate potential contami

236 We describe a novel protein, sisters on the loose (SOLO), which is essential for meiotic cohesion in

237 Compared with loose states, tight states have higher levels of social

238 creativity, and lower happiness relative to loose states.

239 nd their most predominant feature was bloody loose stool (78%).

240 f three or more loose stools in 24 h, or one loose stool with visible blood) were identified through

241 e, 35% had abdominal pain, 24% had nonbloody loose stool, 18% had vomiting, 18% had weight loss, and

242 l pain and bloating scores of 3 or more, and loose stool, located at 270 centers in the United States

243 weight loss, and 5% had intermittent bloody loose stool.

244 (0.5 days vs 2.1 days, p=0.0006) with fewer loose stools (3.7 vs 10.5, p<0.0001) than placebo.

245 oup reductions in abdominal pain (p < 0.01), loose stools (p < 0.01), bloating (p < 0.05), flatulence

246 rrheal illness <7 d duration comprising >/=3 loose stools in 24 h and >/=1 of the following: sunken e

247 (defined as maternal report of three or more loose stools in 24 h, or one loose stool with visible bl

248 Diarrhoea was graded by the number of loose stools in 24 h: mild (three), moderate (four or fi

249 years old, hospitalized with diarrhea (>/=3 loose stools in 24 hours) at two district hospitals in N

250 ic inflammation and has a high prevalence in loose stools in humans(1,2).

251 from baseline and a decrease in frequency of loose stools of >/=50% from baseline, for 2 or more week

252 e diarrhoea (defined by WHO as three or more loose stools per day for less than 14 days).

253 ossibility when the patient has fewer than 3 loose stools per day; the glutamate dehydrogenase test f

254 Secondary hyperparathyroidism and loose stools were more frequent after distal gastric byp

255 s return, he developed diarrhea, cramps, and loose stools without blood or mucus in the absence of fe

256 BD exacerbations (ie, increased frequency of loose stools, abdominal pain), it is hard to differentia

257 lated gastrointestinal side effects (nausea, loose stools, vomiting) were common but did not limit th

258 fever, associated with vomiting and frequent loose stools.

259 oswitch aptamers without their ligands and a loose structure for the recently discovered human HoxA9D

260 arrestin-3 we show that the presence of this loose structure is correlated with reduced arrestin sele

261 ilock braking system (ABS) for vehicles on a loose surface.

262 tion rate (Descemet's folds, epitheliopathy, loose sutures) was 18%.

263 eval of connectivity, the synchrony evolves: Loose synchrony appears already at weak connectivity, wi

264 eptual problem in contemporary neuroscience: Loose talk of "coding" sometimes leads to a conflation o

265 the inner plexiform layer (IPL) and formed a loose, tangential plexus in the middle of this layer.

266 perception of gum disease, teeth/gum health, loose teeth and history of tooth loss.

267 n China where a partial skullcap and several loose teeth of Homo erectus have been discovered.

268 ng "bone loss/deep pockets" (P < 0.001) and "loose teeth" (P < 0.001).

269 self-reported "bone loss/deep pockets" and "loose teeth" was assessed; associations of self-report w

270 Scaling and root planing treatments, loose teeth, and the use of mouthwash, combined with dem

271 orating self-report measures on gum disease, loose teeth, and tooth appearance alone were most useful

272 all rating, tooth extractions, gum bleeding, loose teeth, bone loss around teeth, and gum disease-cro

273 f-reported gum health and treatment history, loose teeth, bone loss around teeth, tooth not looking r

274 Among patients with RA, "loose teeth," but not other self-report items, was assoc

275 For many years, menstrual migraine was a loose term used to describe an undefined association bet

276 However, the account is limited by loose terminology, and by its commitment to a view of th

277 only induce a stoichiometric shift but also loose the coupling between available N and P.

278 Cells loose their apical-basal polarity, mislocalize DE-cadher

279 and because the best long-range bound is too loose to accurately describe the relevant dynamical time

280 ures into an infectious form, morulae become loose to allow bacteria to exit from host cells to infec

281 The peptide prevented transition from the loose to the tight FXa-TFPI complex, but did not affect

282 a inhibition, i.e. for the transition of the loose to the tight FXa-TFPI complex.

283 ng the developmental homeostatic switch from loose to tightly coupled synaptic release at a single cl

284 tive and stochastic methods and by employing loose tolerances to limit the number of iterations in th

285 hosphate (GTP) hydrolysis proceeds through a loose transition state as suggested in our previous stud

286 d GTP hydrolysis reaction proceeds through a loose transition state that is similar in nature to the

287 eneral acid catalysis, are consistent with a loose transition state with partial neutralization of th

288 gen and the pro-S beta nonbridge oxygen of a loose transition state, whereas Lys-16 of Ras and Mg(2+)

289 The computed loose transition states are clearly different from the m

290 The calculations suggest that similar loose transition states are involved in both enzymes, de

291 sulfate diester hydrolysis proceeds through loose transition states, with minimal bond formation to

292 se ions fragment by the loss of pyridine via loose transition states.

293 bservations are best explained by calculated loose transition structures with extensive scissile bond

294 the rate-limiting hydrolysis step and a very loose TS.

295 ween particles is also reduced, resulting in loose, unstable and an easily removed biofilm structure.

296 toward simple shapes depicted as proxies for loose versus tight social circles.

297 blood with bowel movements (BM) (86.6%) and loose/watery BMs (86.5%) were most common in UC.

298 n where the interhelical contacts are rather loose, while the motif's center with best established co

299 h is unable to trigger target cell lysis, is loose, with multiple protrusions in the effector cell me

300 ure, and modulates terminal DNA to match the loose wrap that is found on native CENP-A nucleosomes at