ライフサイエンスコーパス: loss

1 rtal hypertension, malabsorption, and weight loss).

2 h outcomes (increased probing depth and bone loss).

3 vant understanding of the causes of mangrove loss.

4 ly indicates the glaucomatous central visual loss.

5 minuria were equally good at predicting eGFR loss.

6 asure progression of structural glaucomatous loss.

7 ay decrease weight regain and improve weight loss.

8 and a large YS reliably predicted pregnancy loss.

9 ms underlying the anxiogenic impact of sleep loss.

10 07) were associated with lower risk of graft loss.

11 inconsistently to FGF21 treatment and weight loss.

12 therapeutic intervention in early pregnancy loss.

13 lization precedes maternal (egg cell) genome loss.

14 s evaluation and treatment are causing sight loss.

15 re increasingly important drivers of biomass loss.

16 lethal intestine degeneration upon autophagy loss.

17 between stress and sister chromatid cohesion loss.

18 al habitats is a major cause of biodiversity loss.

19 significantly delayed the onset of allograft loss.

20 poor, questioning the unique role of axonal loss.

21 composite of estimated GFR halving and graft loss.

22 functional group, independent of live coral loss.

23 model of melanoma driven by BRAF(V600E);PTEN loss.

24 the proneoplastic effects of Nkx3.1 allelic loss.

25 itis with joint remodeling and profound bone loss.

26 cellular damage preceded the photoreceptors loss.

27 explains a common root cause of performance losses.

28 ng in significant environmental and economic losses.

29 ence such populations because of compounding losses.

30 ne quality resulting in significant economic losses.

31 Successful weight loss (-11+/-5% body weight) was associated with improvem

32 te and low-fat diets can both lead to weight-loss, a substantial variability in achieved long-term ou

33 es subjects for future severity of C-peptide loss after 1 year.

34 d durability showing no significant activity loss after 5000 cycles and 25 h of operation in acid.

35 olomic analyses show that alpha2-Na/K ATPase loss alters metabolic gene expression with consequent se

36 ed cells to mitochondrial membrane potential loss and apoptosis.

37 ach scan pattern were compensated for signal loss and averaged.

38 Predator loss and climate change are hallmarks of the Anthropocen

39 her quality parameters such as texture, drip loss and colour were evaluated with thawed samples.

40 ity may not directly underpin Ag-expTh1 cell loss and exhaustion during malaria infection.

41 ains observed patterns of geographical range loss and expansion across continents.

42 n may help to explain the phenomenon of bone loss and increased adipogenesis in some patients during

43 Interindividual variability in weight loss and metabolic responses depends upon interactions b

44 here would be a correlation between expansin loss and morphological reductions seen among highly adap

45 tute both the greatest cause of biodiversity loss and the greatest opportunity for conservation(1,2),

46 D) is characterized by dopaminergic neuronal loss and the presence of intra-neuronal Lewy body (LB) i

47 intake was the strongest correlate to weight loss and was logarithmically related to gastric volume.

48 Two-year therapy prevented a 1-month-of-life loss, and revealed bevacizumab, ranibizumab, and afliber

49 It also evaluated whether smell or taste loss are indicative of COVID-19 infection.

50 pramine administration reduced alveolar bone loss as histologically observed, and modulated key bone

51 Graft loss at 1 month and 1 year was similar between groups (O

52 The higher whey protein loss at low pH likely contributed to increased cheese ha

53 up developed greater acute axonal and myelin loss attributed to elevated oxidative stress through NAD

54 uce six principles in behavioural economics (loss aversion, framing effect, present bias, status quo

55 ression also exhibited alleviated bodyweight loss, behavioral sickness, and myocardial dysfunction.

56 plexity of global supply chains will magnify losses beyond the direct effects of COVID-19.

57 It is considered a major cause of health loss, but data for the global burden of sepsis are limit

58 problems in noise, known as "hidden hearing loss," but existing studies are controversial.

59 1%, 35% and 20%, respectively; and the water loss by about 5%, 15% and 0%, respectively.

60 hippocampal (and other brain region) volume loss by assessing its relationship to measures of amyloi

61 hat Col6a2 deficiency causes trabecular bone loss by enhancing osteoclast differentiation through enh

62 n of adipose OGT causes a rapid visceral fat loss by specifically promoting lipolysis in visceral fat

63 proportion of sites with clinical attachment loss (CAL) >= 3 mm] were estimated using robust logistic

64 The losses can be worse among those who are more vulnerable

65 These screens identified 890 genes whose loss causes either sensitivity or resistance to DNA-dama

66 erve that genetic and RNAi-mediated LincIRS2 loss causes elevated blood glucose, insulin resistance a

67 Endothelial cell loss did not differ significantly between the treatment

68 As a physical response to water loss during drought, inner Selaginella lepidophylla stem

69 n reported to protect from pathological bone loss during rheumatoid arthritis and osteoporosis, whose

70 rie diet (LCD) resulting in >=8% body weight loss, during which changes in body composition (by DXA)

71 erence of species-specific sequence gain and loss easy for both expert and non-expert users, making i

72 unication at a rate that surpasses the ideal loss-equivalent direct-transmission method while operati

73 on- and assemblage-level shifts after forest loss extended up to 50 years and increased with species'

74 related sequelae (neurologic and/or hearing loss) following a maternal infection in the first trimes

75 Especially devastating periods of coral loss frequently occur during El Nino-Southern Oscillatio

76 global sea-level change as a result of mass loss from ice sheets is strongly nonuniform, owing to gr

77 nding risk of sudden and severe biodiversity losses from climate change and provide a framework for p

78 ice (sea ice, ice shelf and glacier retreat) losses generate a valuable negative feedback on climate

79 ere is a furcal lesion with periodontal bone loss; Group I (intermediate) in which the border of the

80 c capacity, having >=5 illnesses, and weight loss >=5%.

81 redicting and preventing recurrent pregnancy loss has been hampered by a lack of standardized definit

82 Recently, hearing loss has been identified as potentially the most modifia

83 nds that reduce hyperexcitability and neuron loss, have anti-inflammatory properties, and are well to

84 ndida spp. was associated with a substantial loss in bacterial burden and diversity, particularly in

85 year-old woman presented with gradual vision loss in both eyes and nyctalopia for 2 years.

86 Mucosa-associated invariant T (MAIT) cell loss in chronic HIV-1 infection is a significant insult

87 ion following eutrophication-driven seagrass loss in Cockburn Sound (23 km(2) between 1960s and 1990s

88 s of these maps documents the single largest loss in dense seagrass extent globally (1,310 km(2) ) fo

89 3 activation may benefit neurons from spine loss in diseases, at least, in those with F1Fo ATP synth

90 Despite the loss in Faradaic efficiency, the electrocatalysts exhibi

91 t parathyroid hormone (PTH) only caused bone loss in mice whose microbiota was enriched by the Th17 c

92 whereas cone-driven responses supplement the loss in rod-driven sensitivity to slow temporal variatio

93 NAC reduced risk of macular loci sensitivity loss in RP.

94 , conserves nitrogen, and minimizes nutrient loss in soils.

95 CH induction in male mice caused profound HN loss in the affected hemisphere.

96 s topic because they show high levels of leg loss in the field but do not regenerate their legs.

97 ctivation and prevented photoreceptor neuron loss in the retina.

98 xenograft tumor growth and induces survivin loss in tumors.

99 ation/disturbance accounting for >75% of the losses in 7 countries.

100 y as a proof of concept, we show significant losses in functional plant diversity when converting nat

101 ons for the Arctic region, including sea ice loss, increased geopolitical attention, and expanding ec

102 Sleep loss increases the cerebrospinal fluid concentration of

103 Our platform allows for control of the local losses inside the network and of the violation of time-r

104 this suggests considering more general gain-loss interactions.

105 earing loss, we estimate that 56% of hearing loss is genetic and 44% is not genetic.

106 Weight loss is highly effective in preventing T2D; however, the

107 atopoietic changes caused by heterochromatin loss is lacking.

108 The diagnosis of an early pregnancy loss is relatively straightforward, although progress in

109 In conclusion, if weight loss is the primary goal of surgical intervention, signi

110 AN loss is widely expected to cause hearing problems in noi

111 Shot loss leads to double-strand break (DSB) DNA damage, and

112 the extracellular matrix (ECM) and that its loss leads to impaired ECM engulfment and a concomitant

113 short-run effects on economic activity, with losses likely concentrated in coastal lowlands that are

114 s, but the role of sleep in long-term weight loss maintenance (WLM) has not been thoroughly explored

115 cipants were randomly assigned into 5 weight loss maintenance diets based on protein and glycemic ind

116 This loss may be associated with the observed phenotype chang

117 and rapid joint destruction (including bone loss) may be observed in patients who received IACS inje

118 ts in the DJBL group experienced greater BMI loss [mean adjusted difference (95% confidence interval,

119 possible causal relationship between hearing loss, neural reorganisation, and cognitive impairment.

120 disease (IRD) associated with severe visual loss, nystagmus, amaurotic pupils, oculo-digital sign an

121 Significant marginal bone loss occurred in the early post-diagnosis period of peri

122 hat this reduction is the main cause for the loss of 5hmC.

123 r than autotrophic sources, and equated to a loss of 8.2 +/- 4.2 (one standard error) tonnes of carbo

124 Remarkably, loss of a single allele of Cebpb prevented the pro-infla

125 valuated clinical outcomes, including age at loss of ambulation (p < 0.001).

126 Loss of androgen receptor (AR) signaling dependence occu

127 increased translational efficiency following loss of ARF include many ribosomal proteins and translat

128 Loss of ATG16L1 from IECs increases markers of inflammat

129 f enzyme-analyte complexes and a competitive loss of available binding sites for glyphosate-functiona

130 Loss of barbed-end binding increases nucleation by Spire

131 A partial loss of BCCIP function was sufficient to trigger genomic

132 ications for understanding why a hypomorphic loss of BCCIP functions is more relevant to tumorigenesi

133 The cause of this selective loss of beta cells needs to be further elucidated but ov

134 We further show that loss of both Trp53 and Rb1 disables transcription of gen

135 CPM-733-dps is stable and shows no loss of C(2) H(2) adsorption capacity following multiple

136 sitive effects on specific volume and baking loss of cakes, whilst, their incorporation increased the

137 ckout (KO) mouse incapable of FAO due to the loss of carnitine palmitoyltransferase 2, the product of

138 d changes in surface ultrastructure with the loss of cell surface protrusions and poor aggregation, r

139 llelic inactivation of ELP1 owing to somatic loss of chromosome arm 9q.

140 The loss of CO from the precursor during electron-induced de

141 ed assay that uses the temperature-dependent loss of conformational epitopes to measure thermostabili

142 The loss of conformational heterogeneity and related functio

143 Knockdown of CTCF in K562 cells caused loss of CTCF binding and transcriptional repression of g

144 Functional studies suggest that the loss of dAKAP1-RNA interactions reduces mitochondrial el

145 Functional impairment and loss of dental enamel, caused by developmental defects o

146 n culminating in extensive, highly selective loss of DG GCs (thereby also reinforcing the notion of s

147 Parkinson's disease is caused by a loss of dopaminergic input from the substantia nigra to

148 and reduced insulin content associated with loss of eIF4E, the mRNA 5'-cap binding protein of the in

149 Loss of either of these kinases results in paralysis and

150 Loss of endosymbiotic algae ("bleaching") under heat str

151 The loss of EPCR appeared to associate with increased diseas

152 included cytoplasm vacuolization and partial loss of epidermal stratification.

153 Results might have been confounded by loss of equipoise over the course of the trial, resultin

154 Together, these results suggest that the loss of exogenous immunity from foliage under eCO(2) res

155 the world, leaving many grieving the sudden loss of family members.

156 dation of the perovskite leads to an initial loss of formamidinium [CH(NH(2))(2) (+)] ions, leaving b

157 ure evolution of aroma, characterized by the loss of fresh fruit and development of dried fruit flavo

158 n damage the polymer's integrity, leading to loss of function and properties.

159 Moreover, Med19 loss of function experiments in vivo or in cellulo indic

160 Therefore, it remains unknown how SYNGAP1 loss of function impacts the development and function of

161 harboring recurrent cancer mutations exhibit loss of function in modulating the Hippo pathway, induci

162 Previous studies demonstrated that loss of function of ANK or ENPP1 (reducing PP(i)) result

163 ucts, and the need to consider both gain and loss of function to develop safe and effective therapeut

164 compare mutation-induced changes to genuine loss of function.

165 Results show that loss of gammaC0C7 reduced myofilament Ca(2+) sensitivity

166 mmasome activation, polymorphisms that cause loss of gasdermin D function convert inflammatory pyropt

167 Loss of gut mucosal integrity and an aberrant gut microb

168 the immunodominant TMEV peptide VP2(121-130) Loss of H-2D(b) on CD11c(+) APCs mitigates the CD8 T cel

169 Loss of HDAC3 in macrophages safeguards mice from lethal

170 ons (indels), copy-number variations (CNVs), loss of heterozygosity (LOH) and complex rearrangements,

171 Finally, we demonstrate that loss of heterozygosity and temporal dissection of mutati

172 neurofibromatosis and 6 weeks after complete loss of his allograft due to severe CAMR.

173 mall sclerophyllous leaves and lower percent loss of hydraulic conductivity.

174 Loss of KBTBD2 in all tissues causes the teeny phenotype

175 The loss of KDM4A in oocytes causes aberrant H3K9me3 spreadi

176 Loss of KDM5A also resulted in dysregulation of the hipp

177 Interestingly, the loss of maternal SMCHD1 does not alter germline DNA meth

178 While the specific cause(s) underlying the loss of melanogenically-active melanocytes from the anag

179 Thus, the precise cell types whose loss of mitochondrial activity and altered mtDNA copy nu

180 enzymes, we used genome editing to study the loss of mmachc function and to develop the first viable

181 ntra-acinar ductular cells and the scattered loss of myoepithelial cells are other abnormalities in d

182 Furthermore, loss of N-WASP reduces the diffusivity of CD19, a stimul

183 A global goal of no net loss of natural ecosystems or better has recently been p

184 Degradation and loss of natural habitat is the major driver of the curre

185 arge body mass, increase in air temperature, loss of natural land, and high human population density.

186 genomic profiling to reveal strong and broad loss of neural APA in elav/fne double mutant CNS, the fi

187 GK1) are constitutively activated in MN with loss of NF2.

188 Many of these variants cause complete loss of NHE6 expression, but how subtler missense substi

189 Thus, our results suggest that a loss of NOD-LNSC MHC-independent suppressive mechanisms

190 D1 patients with this mutation are caused by loss of O-fucosylation on TSR3 and impaired ADAMTSL2 sec

191 itor of ferroptosis that prevents CZ-induced loss of OL and demyelination, providing clear evidence o

192 totic response is exacerbated by concomitant loss of p53.

193 ng iBCIs can be relaxed considerably without loss of performance.

194 CRK9 depletion also caused a loss of phosphorylation in RPB1, the largest subunit of

195 M189 gene in human HAP1 cells led to a total loss of plasmanylethanolamine desaturase activity, stron

196 insulin signaling mutants, but surprisingly, loss of PQM-1 increases survival under hypoxic condition

197 leads to detrimental cascades, resulting in loss of precious time, money and finally compromised dat

198 te whether PRS models can be applied-without loss of precision-to populations of similar ethnic but d

199 rovide direct evidence that oncogene-induced loss of progenitor self-renewal is driven by eIF2B5-medi

200 ation, and inflammatory demyelination due to loss of protective antiviral host immunity.IMPORTANCE Th

201 ese hamster ovary cells showed near complete loss of protein function.

202 I (INPP4B), can partially compensate for the loss of PTEN.

203 Surprisingly, the simultaneous loss of RAP80 and failure therein of BRCA1 PARsylation r

204 activity in the mice at one minute after the loss of righting reflex.

205 Consequently, loss of RIPK1 in keratinocytes induces ZBP1-dependent ne

206 with changed CTCF binding in AML, as well as loss of RUNX1 binding at RUNX1/CTCF-binding sites.

207 Moreover, loss of SDE2 or TIM results in an excessive MRE11-depend

208 produce hereditary PPGL through Cre-mediated loss of SDHC in cells that express tyrosine hydroxylase

209 Loss of SEP-1 results in extra surviving cells in a weak

210 In addition, freeze-drying caused a relative loss of short chain fatty acids (SCFA).

211 New loss of smell was more prevalent in participants with SA

212 ing to dramatic community changes, including loss of species and function.

213 The loss of splenic ESAM(+) cDC2s was cell-intrinsic and cou

214 Loss of SSD1 recapitulates myriad aneuploidy signatures

215 e-directed mutagenesis approach, we identify loss of STAT3 O-GlcNAc at Threonine 717 as a driver of a

216 leading to reduced production of collagens, loss of structural integrity of the cuticle, and impaire

217 considered here could result in a potential loss of suitable habitat in Minnesota for both buckthorn

218 We show that loss of sympathetic innervation is ongoing in canine DM

219 rmation characterized by partial or complete loss of the cerebellar vermis with fusion of the cerebel

220 Mechanistically, we find that loss of the Elf5-regulated ubiquitin ligase FBXW7 ensure

221 lagella, aberrant ventral disk organization, loss of the funis, defective axoneme exit, and altered c

222 Here, we focus on loss of the histone demethylase UTX (also known as KDM6A

223 ense mutation RFX6 c.1129C>T, which revealed loss of the pancreas body and tail.

224 resulting products-does not account for the loss of the parent compound observed during the initial

225 In the zmnlp5 mutant plants, loss of the ZmNLP5 function led to changes in expression

226 ng ex vivo pressure myography, we found that loss of this critical signaling cascade exaggerated the

227 blood-brain barrier (BBB) integrity through loss of tight junction protein claudin-5 (cldn5) in male

228 Loss of TIPE0 in mice results in injury-resistant entero

229 To test whether loss of TMPRSS13 impacts tumor progression, TMPRSS13 was

230 But to successfully avert the loss of transboundary species, the global community must

231 2-dialkylaminobenzoxazoles with concomitant loss of triphenylphosphine oxide, suggesting their possi

232 Loss of tRNA modifications frequently results in severe

233 p2 induces tumor growth and metastasis while loss of Trop2 suppresses these abilities in vivo.

234 The loss of uninfected erythrocytes is an important contribu

235 n transient MLL1 inhibition caused a durable loss of ventral identity, resulting in the generation of

236 ntify synthetic lethal interactions with the loss of VHL through analysis of primary tumor genomic an

237 mild to severe, but many cause irreversible loss of viability.

238 the naive T cell compartment in mice, where loss of VISTA disrupted the major quiescent naive T cell

239 characterized by gradual-rather than sudden-loss of visual processing.

240 the transcriptional repressor SPEN(1-3), the loss of which has been associated with deficient XCI at

241 Loss of Yap in T cells results in enhanced T-cell activa

242 Loss of ZNF410 in adult-type human erythroid cell cultur

243 aB pathway genes (CARD11, CD79B, and MYD88), losses of 17p13 and gains of chromosome 7, 11q12.3-q25,

244 eg, SOCS1 and KMT2D), gains of 2p16/REL, and losses of 19p13/CD70.

245 ement-resistant symptoms are associated with losses of basal forebrain and striatal cholinergic neuro

246 global grain yields, but have also increased losses of reactive N to the environment.

247 ss at the spatial scale of a study site, the losses of small-ranged species reduce biome-scale (gamma

248 ty analysis revealed significant genome-wide losses of variation among the three stages and supports

249 e identified twelve individuals with de novo loss-of-function (LoF) variants in protein phosphatase 1

250 Consistent with being loss-of-function alleles, we show using patients' primar

251 IFITM1, IFITM2, and IFITM3, using gain- and loss-of-function approaches.

252 erall, we identified a significant excess of loss-of-function DNMs in genes highly expressed in crani

253 By a loss-of-function genetic screening of individual IFN-sti

254 ducible genes RPL4A and RPL4D, and that RPL4 loss-of-function increases osmotic stress tolerance and

255 Here, we highlight known loss-of-function mechanisms underlying ALS, potential co

256 imilar to the rgi1/2/3/4/5 quintuple mutant, loss-of-function mutants of MPK3 and MPK6, MKK4 and MKK5

257 tasets (adjusted OR = 1.55, P = 0.06) with a loss-of-function mutation, Q4X (rs150665432) of an uncha

258 an alteration in gene function rather than a loss-of-function mutation.

259 l ligand identification and the discovery of loss-of-function mutations associated with human disease

260 Homozygous loss-of-function mutations in SLC39A8 result in undetect

261 e of the variants are predicted to result in loss-of-function of the protein.

262 in both sporadic and familial PD upon parkin loss-of-function remains unknown.

263 Cell surface-based loss-of-function screens reveal that ATP7A, a copper-exp

264 Bi-allelic loss-of-function variants in genes that encode subunits

265 , a mutation of bicra that mimics one of the loss-of-function variants leads to craniofacial defects

266 ergistic impacts of warming and biodiversity loss on ecosystem functioning were mediated by thermal t

267 ners to examine potential effects of hearing loss on EEG correlates of speech envelope synchronizatio

268 rm for experiments of quantum effects in low-loss optical fibers which is critical for scalability of

269 riatric surgery is the most effective weight loss option for Veterans with severe obesity, but fewer

270 In this study, we examined whether the loss or overexpression of the membrane-bound ephrin-B1 i

271 ailure (biopsy-proven acute rejection, graft loss, or death), delayed graft function, patient and gra

272 ively increased despite of accumulated sleep loss over days.

273 Also, they reduced weight loss, oxidative stress, and the anthracnose (Colletotric

274 and (3) computationally derived archetype VF loss patterns.

275 eners with age-related sensorineural hearing loss (presbycusis) often struggle to understand speech i

276 Therefore, neuronal loss rather than inflammation was critical for AD progre

277 SPRR3 loss resulted in reduced activation of PDGFRbeta in fibr

278 Thus, CHD1 loss results in chromatin dysregulation, thereby establi

279 Visual field (VF) loss severity is associated with higher driving simulato

280 of the constrained problem of minimizing the loss subject to a unit norm constraint.

281 tegies geared toward reducing surgical blood loss such as autologous transfusion techniques and agent

282 izes in the comb, representing a significant loss to apiarists.

283 Control and treatment arm loss to follow-up and withdrawal were 24% and 23%, respe

284 and mortality, the minimum amount of weight loss to have a meaningful impact on cardiovascular healt

285 police raids and scams regularly cause large losses to marketplace participants.

286 hyperosteoclastogenesis, and trabecular bone loss, uncovering a pathological mechanism underlying the

287 nt of SOC along the soil profile reduces SOC loss under warming.

288 with or at risk of glaucomatous visual field loss was "detected" if >= N(theta) clusters had deterior

289 Kupffer cell loss was compensated by gain of adjacent monocyte-derive

290 3.4% versus 78.7%, p < 0.001), whereas taste loss was equally prevalent (90.2% versus 89.0%, p = 0.73

291 Periodontal bone loss was measured via histological and microcomputed tom

292 au lines show promise as high frequency, low-loss waveguides on a substrate.

293 an families with no prior history of hearing loss, we estimate that 56% of hearing loss is genetic an

294 No clinical signs or weight loss were observed.

295 Ratios for mortality and graft loss were similar between VA centers and their respectiv

296 1.83; P < 0.001) were associated with graft loss, whereas more recent period of LT 2012-2015 (aHR, 0

297 l damage leading to demyelination and axonal loss, which are pathological features of multiple sclero

298 of deadwood that experienced 6.3-98.8% mass loss while decaying in common garden 'rotplots' in a tem

299 use change is a major driver of biodiversity loss worldwide.

300 t threat to agriculture causing annual yield losses worth more than 100 billion US$.