ライフサイエンスコーパス: loss of

1 aB pathway genes (CARD11, CD79B, and MYD88), losses of 17p13 and gains of chromosome 7, 11q12.3-q25,

2 eg, SOCS1 and KMT2D), gains of 2p16/REL, and losses of 19p13/CD70.

3 1851 CE (Common Era), and it resulted in the loss of 59 lives and $25 billion in damages across the s

4 hat this reduction is the main cause for the loss of 5hmC.

5 ly greater horizontal shrinkage in the test (loss of 7.59% +/- 10.20%) compared with the control (sma

6 r than autotrophic sources, and equated to a loss of 8.2 +/- 4.2 (one standard error) tonnes of carbo

7 he possible evolutionary implications of the loss of a dedicated olfactory organ in spiders and its e

8 Here, we show that conditional loss of a Mediator complex subunit protein, Med23 in mou

9 sation of skull structure in birds-including loss of a separate postorbital bone in adults and the em

10 Remarkably, loss of a single allele of Cebpb prevented the pro-infla

11 ity, and enables lyophilized storage without loss of activity.

12 valuated clinical outcomes, including age at loss of ambulation (p < 0.001).

13 Irrigated systems had significantly higher losses of ammonia, and pasture agroecosystems had higher

14 Loss of androgen receptor (AR) signaling dependence occu

15 increased translational efficiency following loss of ARF include many ribosomal proteins and translat

16 This loss of ARNT was associated with decreased levels of Not

17 Further, the loss of Ascl1 yielded a similar delay in neuronal birth,

18 Loss of ATG16L1 from IECs increases markers of inflammat

19 Loss of ATP sensing in macrophages may reduce their secr

20 f enzyme-analyte complexes and a competitive loss of available binding sites for glyphosate-functiona

21 Loss of barbed-end binding increases nucleation by Spire

22 ement-resistant symptoms are associated with losses of basal forebrain and striatal cholinergic neuro

23 ns are associated with a rapid and selective loss of BBB transcripts and chromatin features, as well

24 sionalized implants is accompanied with more loss of BBT, but at the same time better maintains the m

25 A partial loss of BCCIP function was sufficient to trigger genomic

26 ications for understanding why a hypomorphic loss of BCCIP functions is more relevant to tumorigenesi

27 The cause of this selective loss of beta cells needs to be further elucidated but ov

28 Loss of beta-PIX promoted podocyte apoptosis, which was

29 s a common disorder resulting from increased loss of bile acids (BAs), overlapping irritable bowel sy

30 We conclude by reviewing the loss of bone density in patients with AD, paralleling th

31 er than where there was simultaneous genetic loss of both (n = 87) (mean survival 1670.8 +/- 183.5 da

32 We further show that loss of both Trp53 and Rb1 disables transcription of gen

33 CPM-733-dps is stable and shows no loss of C(2) H(2) adsorption capacity following multiple

34 sitive effects on specific volume and baking loss of cakes, whilst, their incorporation increased the

35 ity of using the CRISPR-Cas9 system to model loss of candidate tumor suppressor genes in SCLC, and we

36 geted by mitochondrial toxins resulting in a loss of cardiac function.

37 ckout (KO) mouse incapable of FAO due to the loss of carnitine palmitoyltransferase 2, the product of

38 l program caused impairment in self-renewal, loss of cell identity, and premature exhaustion of the q

39 d changes in surface ultrastructure with the loss of cell surface protrusions and poor aggregation, r

40 dentify an epigenomic continuum representing loss of cellular identity and progression toward a metas

41 llelic inactivation of ELP1 owing to somatic loss of chromosome arm 9q.

42 lymphocytic leukaemia (including trisomy 12, loss of chromosomes 13q and 13q, and copy-neutral loss o

43 Mutations that cause the loss of ClC-2 function lead to retinal and testicular de

44 The loss of CO from the precursor during electron-induced de

45 It has been suggested that an age-related loss of cognitive function might be driven by atheroscle

46 ive transcriptome analysis revealed that the loss of COL6 is associated with reductions in integrin-p

47 bile acids (BA) in western diet (WD)-induced loss of colonic epithelial barrier (CEB) function in mic

48 ed assay that uses the temperature-dependent loss of conformational epitopes to measure thermostabili

49 The loss of conformational heterogeneity and related functio

50 and cellular effects, how anesthesia induces loss of consciousness (LOC) and affects sensory processi

51 ical neuronal dynamics during transitions of loss of consciousness (LOC) with the alpha2-adrenergic a

52 Knockdown of CTCF in K562 cells caused loss of CTCF binding and transcriptional repression of g

53 Functional studies suggest that the loss of dAKAP1-RNA interactions reduces mitochondrial el

54 e synaptic calcium dysregulation is due to a loss of dendritic inhibition via decreased NMDAR current

55 Functional impairment and loss of dental enamel, caused by developmental defects o

56 Loss of developmental stage-specific constraint in macro

57 n culminating in extensive, highly selective loss of DG GCs (thereby also reinforcing the notion of s

58 lizes the ryanodine complex, did reverse the loss of diaphragmatic force associated with mechanical v

59 sis show a significant reduction or complete loss of differential gene expression at 24 h post inocul

60 Although activity-related loss of DNA methylation requires the Gadd45 (Growth arre

61 Loss of Dnmt3a causes global loss of mCH and a subset of

62 sulted in severe motor impairment, selective loss of dopamine neurons and increased astrocyte activat

63 mice induces DCC cleavage and a significant loss of dopamine neurons, resulting in motor deficits.

64 Parkinson's disease is caused by a loss of dopaminergic input from the substantia nigra to

65 neurodegenerative disorder, characterized by loss of dopaminergic neurons in the midbrain.

66 RAZUL by CRISPR-based gene editing leads to loss of E6AP at proteasomes.

67 Discontinuation was due to lack or loss of efficacy in 74 patients, adverse event in 34 pat

68 and reduced insulin content associated with loss of eIF4E, the mRNA 5'-cap binding protein of the in

69 Loss of either of these kinases results in paralysis and

70 We found that loss of either ZFX or ZNF711 reduced cell growth and tha

71 The low propagation loss of electromagnetic radiation below 1 MHz offers sig

72 caused by inactivation of the FMR1 gene and loss of encoded FMRP, an RNA binding protein that repres

73 Loss of endosymbiotic algae ("bleaching") under heat str

74 tially disrupt its oligomerization and cause loss of enzymatic activity and translocation from the nu

75 The loss of EPCR appeared to associate with increased diseas

76 included cytoplasm vacuolization and partial loss of epidermal stratification.

77 Decreased PE synthesis from loss of EPT1 or PSD1 and PSD2 leads to downregulation of

78 Results might have been confounded by loss of equipoise over the course of the trial, resultin

79 Severe loss of excitatory synapses in key brain regions is thou

80 Together, these results suggest that the loss of exogenous immunity from foliage under eCO(2) res

81 We noted loss of expression of miR-299-3p in prostate tumors comp

82 the world, leaving many grieving the sudden loss of family members.

83 dation of the perovskite leads to an initial loss of formamidinium [CH(NH(2))(2) (+)] ions, leaving b

84 ure evolution of aroma, characterized by the loss of fresh fruit and development of dried fruit flavo

85 n damage the polymer's integrity, leading to loss of function and properties.

86 Moreover, Med19 loss of function experiments in vivo or in cellulo indic

87 Therefore, it remains unknown how SYNGAP1 loss of function impacts the development and function of

88 harboring recurrent cancer mutations exhibit loss of function in modulating the Hippo pathway, induci

89 Previous studies demonstrated that loss of function of ANK or ENPP1 (reducing PP(i)) result

90 hown that mutations of TP53 not only lead to loss of function or dominant negative effects, but also

91 ggest that altered metabolism induced by SXR loss of function resulted in the accumulation of hydroxy

92 sistance was determined in in vitro gain-and-loss of function studies and confirmed in subcutaneous a

93 We attribute loss of function to defects in a chemical interaction ne

94 ucts, and the need to consider both gain and loss of function to develop safe and effective therapeut

95 an patient iPSC-derived microglia expressing loss of function variants in TREM2.

96 in the human population that are potentially loss of function, and residues that modulate basal activ

97 compare mutation-induced changes to genuine loss of function.

98 se-causing genes are generally considered as loss-of-function (LoF) alleles and classified as pathoge

99 we used genome-wide association to identify loss-of-function (LOF) mutations in the efflux pump mtrC

100 e identified twelve individuals with de novo loss-of-function (LoF) variants in protein phosphatase 1

101 Consistent with being loss-of-function alleles, we show using patients' primar

102 IFITM1, IFITM2, and IFITM3, using gain- and loss-of-function approaches.

103 ing adenoviruses expressing CaM-wild type, a loss-of-function CaM mutation, CaM (1-4), and a gain-of-

104 erall, we identified a significant excess of loss-of-function DNMs in genes highly expressed in crani

105 KMT2D NCC loss-of-function does exhibit unique phenotypes distinct

106 Gain-of-function and loss-of-function experiments with CYR61 in vivo point to

107 Partial loss-of-function Fech(m1Pas) mutant mice showed reduced

108 By a loss-of-function genetic screening of individual IFN-sti

109 By contrast, we show that TMEM30A loss-of-function increases B-cell signaling following an

110 ducible genes RPL4A and RPL4D, and that RPL4 loss-of-function increases osmotic stress tolerance and

111 roprotein convertase subtilisin/kexin type 9 loss-of-function is associated with improved sepsis outc

112 Conversely, ATXN1 loss-of-function is implicated in cancer development and

113 The C9ORF72 mutation acts through gain- and loss-of-function mechanisms to induce pathways that are

114 Here, we highlight known loss-of-function mechanisms underlying ALS, potential co

115 y parallel screen in human cells to identify loss-of-function missense variants in the key DNA mismat

116 bhlh121 loss-of-function mutants displayed severe defects in Fe

117 Loss-of-function mutants in both homeologs of AP2L2 (hen

118 imilar to the rgi1/2/3/4/5 quintuple mutant, loss-of-function mutants of MPK3 and MPK6, MKK4 and MKK5

119 and root apical meristems observed in fbl17 loss-of-function mutants.

120 tasets (adjusted OR = 1.55, P = 0.06) with a loss-of-function mutation, Q4X (rs150665432) of an uncha

121 an alteration in gene function rather than a loss-of-function mutation.

122 l ligand identification and the discovery of loss-of-function mutations associated with human disease

123 ) is a debilitating genodermatosis caused by loss-of-function mutations in COL7A1 encoding type VII c

124 framework for understanding how heterozygous loss-of-function mutations in histone-modifying enzymes

125 (2020) describe loss-of-function mutations in SERPINA12 as a cause of di

126 Homozygous loss-of-function mutations in SLC39A8 result in undetect

127 Genetic gain-of-function and loss-of-function Na(V)1.7 mutations have been identified

128 e of the variants are predicted to result in loss-of-function of the protein.

129 Loss-of-function of the transcription factor Gli3 is kno

130 in both sporadic and familial PD upon parkin loss-of-function remains unknown.

131 Cell surface-based loss-of-function screens reveal that ATP7A, a copper-exp

132 Gain- and loss-of-function studies of HDAC7 in cultured cardiomyoc

133 Bi-allelic loss-of-function variants in genes that encode subunits

134 Loss-of-function variants in intolerant genes were conce

135 Our results suggest that biallelic loss-of-function variants in SLC7A6OS are a novel geneti

136 , a mutation of bicra that mimics one of the loss-of-function variants leads to craniofacial defects

137 40 putative gain-of-function and 33 putative loss-of-function variants.

138 PCSK9 loss-of-function, in the context of low lipoproteins, ma

139 Thus, early loss of functional OSN innervation reveals latent struct

140 A loss of GABA signaling is a prevailing hypothesis for th

141 Results show that loss of gammaC0C7 reduced myofilament Ca(2+) sensitivity

142 mmasome activation, polymorphisms that cause loss of gasdermin D function convert inflammatory pyropt

143 eted drugs for tumors that are driven by the loss of gene function.

144 s indicating that a potentially catastrophic loss of global biodiversity is on the horizon(1-3).

145 Loss of gut mucosal integrity and an aberrant gut microb

146 the immunodominant TMEV peptide VP2(121-130) Loss of H-2D(b) on CD11c(+) APCs mitigates the CD8 T cel

147 Loss of H3K79me2 led to low expression of STAT5 and impa

148 pletion of SUV420H2 leads to a near-complete loss of H4K20me3 genome wide, dysregulated gene expressi

149 Despite complete loss of hair-cell function, tmc triple-mutant larvae ret

150 Loss of HDAC3 in macrophages safeguards mice from lethal

151 However, loss of Hel2 triggered the integrated stress response, v

152 ons (indels), copy-number variations (CNVs), loss of heterozygosity (LOH) and complex rearrangements,

153 Finally, we demonstrate that loss of heterozygosity and temporal dissection of mutati

154 of chromosomes 13q and 13q, and copy-neutral loss of heterozygosity) were between two and six times l

155 , in the relatively rare cases where genetic loss of HIF1A occurred without genetic loss of L2HGDH (n

156 neurofibromatosis and 6 weeks after complete loss of his allograft due to severe CAMR.

157 hyperproliferation, which leads to complete loss of HSC self-renewal and HSC depletion.

158 Here we show that tacrolimus induces loss of human beta-cell maturity and beta-cell failure t

159 The P(50) values (water potential at 50% loss of hydraulic conductivity) of nonflooded species we

160 mall sclerophyllous leaves and lower percent loss of hydraulic conductivity.

161 er-hexamer dimer interface mutation led to a loss of induced PIP2 clustering in MACA, indicating the

162 Forgetting involves the loss of information over time; however, we know little a

163 The loss of insulin-producing beta-cells is the central path

164 ositive correlation between Psi(leaf) at 50% loss of K(leaf) (K(leaf) P(50) ) and maximum K(leaf) (K(

165 Loss of KBTBD2 in all tissues causes the teeny phenotype

166 The loss of KDM4A in oocytes causes aberrant H3K9me3 spreadi

167 Loss of KDM5A also resulted in dysregulation of the hipp

168 The loss of kinetochore MAD2 was dependent on APC/C(CDC20),

169 Here, we show that lung-specific loss of Kmt2d promotes lung tumorigenesis in mice and up

170 netic loss of HIF1A occurred without genetic loss of L2HGDH (n = 5), the survival was significantly g

171 Global simulations show that continued loss of large animals alone could lead to a 44%, 18% and

172 A hallmark of TLE is the characteristic loss of layer 3 neurons in the medial entorhinal area (M

173 odel found that the adjusted hazard rate for loss-of-license actions for surgeons who failed their fi

174 Polar blue carbon increases with losses of marine ice over high latitude continental shel

175 Interestingly, the loss of maternal SMCHD1 does not alter germline DNA meth

176 Pomgnt1 mutation in zebrafish resulted in a loss of matriglycan, retention of synaptotagmin-1-positi

177 Loss of Dnmt3a causes global loss of mCH and a subset of mCG sites resulting in more

178 land use, hunting, and climate change; (ii) loss of megabiota has a negative impact on ecosystem met

179 While the specific cause(s) underlying the loss of melanogenically-active melanocytes from the anag

180 viable mutants with an essentially complete loss of methylation in the CG and non-CG contexts.

181 r, in mice with C rodentium-induced colitis, loss of MHCII reduces bacterial clearance by decreasing

182 ession differs in males and females and that loss of microRNAs leads to sex-specific changes in the m

183 Thus, the precise cell types whose loss of mitochondrial activity and altered mtDNA copy nu

184 enzymes, we used genome editing to study the loss of mmachc function and to develop the first viable

185 a higher rate of patients with total weight loss of more than 20% (95.8% vs 84.6%, P < 0.001).

186 cterized by severe weight loss with specific losses of muscle and adipose tissue, is driven by reduce

187 Loss of Myoc alone was sufficient to induce phenotypes i

188 ntra-acinar ductular cells and the scattered loss of myoepithelial cells are other abnormalities in d

189 Furthermore, loss of N-WASP reduces the diffusivity of CD19, a stimul

190 A global goal of no net loss of natural ecosystems or better has recently been p

191 Degradation and loss of natural habitat is the major driver of the curre

192 arge body mass, increase in air temperature, loss of natural land, and high human population density.

193 genomic profiling to reveal strong and broad loss of neural APA in elav/fne double mutant CNS, the fi

194 rth, suggesting that Ascl1 cannot rescue the loss of Neurog2 and that these proneural genes act indep

195 Here we combined loss of Nf1 in developing Schwann cells with global Ink4

196 GK1) are constitutively activated in MN with loss of NF2.

197 Many of these variants cause complete loss of NHE6 expression, but how subtler missense substi

198 Thus, our results suggest that a loss of NOD-LNSC MHC-independent suppressive mechanisms

199 The mutation in cmn results in loss of notochord sheath segmentation, altering osteobla

200 D1 patients with this mutation are caused by loss of O-fucosylation on TSR3 and impaired ADAMTSL2 sec

201 itor of ferroptosis that prevents CZ-induced loss of OL and demyelination, providing clear evidence o

202 We further detected a significant loss of OLIG2-positive cells in the corpus callosum of T

203 as the development of or worsening of visual loss of one or more categories.

204 horoid, retinal pigment epithelium loss, and loss of outer retinal layers.

205 initiated tumors in the lung, resulting from loss of p107 or p130 Collectively, these data demonstrat

206 totic response is exacerbated by concomitant loss of p53.

207 n tetra Astyanax mexicanus to understand how loss of parasite diversity influences the evolutionary t

208 ng iBCIs can be relaxed considerably without loss of performance.

209 avior, coupled with metabolic changes due to loss of peripheral catecholamine production.

210 CRK9 depletion also caused a loss of phosphorylation in RPB1, the largest subunit of

211 M189 gene in human HAP1 cells led to a total loss of plasmanylethanolamine desaturase activity, stron

212 insulin signaling mutants, but surprisingly, loss of PQM-1 increases survival under hypoxic condition

213 leads to detrimental cascades, resulting in loss of precious time, money and finally compromised dat

214 te whether PRS models can be applied-without loss of precision-to populations of similar ethnic but d

215 rovide direct evidence that oncogene-induced loss of progenitor self-renewal is driven by eIF2B5-medi

216 ation, and inflammatory demyelination due to loss of protective antiviral host immunity.IMPORTANCE Th

217 ese hamster ovary cells showed near complete loss of protein function.

218 d receptor (GR) levels, which are rescued by loss of PTEN protein-phosphatase activity to restrain ce

219 I (INPP4B), can partially compensate for the loss of PTEN.

220 ay enabled the first characterisation of the loss of Rab-E function.

221 ng a shortened humerus, narrow peduncle, and loss of radial tuberosity, evolved convergently in odont

222 Surprisingly, the simultaneous loss of RAP80 and failure therein of BRCA1 PARsylation r

223 We further find in human cells that loss of RAZUL by CRISPR-based gene editing leads to loss

224 global grain yields, but have also increased losses of reactive N to the environment.

225 have been associated with a highly abnormal loss of redox control in TNBC cells.

226 oor in our peripheral visual field, and this loss of resolution follows an approximately logarithmic

227 provide a global view of the effects of the loss of ribosome recycling on protein synthesis in E. co

228 In loss of righting reflex assessment, knockout mice reveal

229 activity in the mice at one minute after the loss of righting reflex.

230 Consequently, loss of RIPK1 in keratinocytes induces ZBP1-dependent ne

231 hich is susceptible to N-N coupling prior to loss of RSSR.

232 with changed CTCF binding in AML, as well as loss of RUNX1 binding at RUNX1/CTCF-binding sites.

233 Loss of S100A8 and S100A9 in mice altered the phenotypes

234 Moreover, loss of SDE2 or TIM results in an excessive MRE11-depend

235 produce hereditary PPGL through Cre-mediated loss of SDHC in cells that express tyrosine hydroxylase

236 on, epithelial-mesenchymal transition (EMT), loss of sensation and neuropathic pain.

237 Loss of SEP-1 results in extra surviving cells in a weak

238 Loss of SEZ6 reduced surface levels of GluK2/3 in primar

239 In addition, freeze-drying caused a relative loss of short chain fatty acids (SCFA).

240 Loss of SMAD7 in beta cells inhibited proliferation, and

241 ss at the spatial scale of a study site, the losses of small-ranged species reduce biome-scale (gamma

242 s in a community-based population with acute loss of smell and/or taste and to compare the frequency

243 New loss of smell was more prevalent in participants with SA

244 or myogenesis in embryonic slow muscles, and loss of Smyhc1 results in defective sarcomere assembly,

245 ing to dramatic community changes, including loss of species and function.

246 The loss of splenic ESAM(+) cDC2s was cell-intrinsic and cou

247 Loss of SSD1 recapitulates myriad aneuploidy signatures

248 e-directed mutagenesis approach, we identify loss of STAT3 O-GlcNAc at Threonine 717 as a driver of a

249 leading to reduced production of collagens, loss of structural integrity of the cuticle, and impaire

250 considered here could result in a potential loss of suitable habitat in Minnesota for both buckthorn

251 ontinue during modern climate change, future loss of summer Arctic sea ice will accelerate the thawin

252 We show that loss of sympathetic innervation is ongoing in canine DM

253 The truncation leads to a loss of target sites for microRNAs known to repress tran

254 y networks, directly comparing the gains and losses of targets of key TFs across cell states is often

255 phoblast stem cells (RPL-TSCs), we show that loss of TEAD4 is associated with defective self-renewal

256 Loss of Tfr cells led to greatly increased nonspecific I

257 colysis in T cells in mice results in global loss of Th17 cells, whereas deficiency of the glycolytic

258 rmation characterized by partial or complete loss of the cerebellar vermis with fusion of the cerebel

259 Loss of the dome receptor on adult muscles significantly

260 Finally, loss of the Drosophila homologue Lasp from a subset of c

261 Mechanistically, we find that loss of the Elf5-regulated ubiquitin ligase FBXW7 ensure

262 tely eliminated bactericidal activity, while loss of the F-ATPase reduced the electrophysiological re

263 lagella, aberrant ventral disk organization, loss of the funis, defective axoneme exit, and altered c

264 Here, we focus on loss of the histone demethylase UTX (also known as KDM6A

265 Loss of the Hsp104 molecular chaperone leads to the grow

266 (MN), and the majority of NF2 patients show loss of the NF2 tumor suppressor.

267 ense mutation RFX6 c.1129C>T, which revealed loss of the pancreas body and tail.

268 resulting products-does not account for the loss of the parent compound observed during the initial

269 We show that loss of the prolyl hydroxylase domain isoform 1 oxygen s

270 l atrophy, the imaging pattern showed volume loss of the right ventral frontal area and the left temp

271 Loss of the UBR5 HECT domain leads to a block in maturat

272 revealed a negative correlation between the loss of the Y chromosome or linc-SPRY3-2/3/4 and overall

273 In the zmnlp5 mutant plants, loss of the ZmNLP5 function led to changes in expression

274 dful of studies demonstrate the differential loss of these RGC subtypes in response to disease or inj

275 ng ex vivo pressure myography, we found that loss of this critical signaling cascade exaggerated the

276 blood-brain barrier (BBB) integrity through loss of tight junction protein claudin-5 (cldn5) in male

277 Loss of TIPE0 in mice results in injury-resistant entero

278 To test whether loss of TMPRSS13 impacts tumor progression, TMPRSS13 was

279 But to successfully avert the loss of transboundary species, the global community must

280 2-dialkylaminobenzoxazoles with concomitant loss of triphenylphosphine oxide, suggesting their possi

281 Loss of tRNA modifications frequently results in severe

282 p2 induces tumor growth and metastasis while loss of Trop2 suppresses these abilities in vivo.

283 Oncogene activation and loss of tumor suppressor function changes the metabolic

284 The loss of uninfected erythrocytes is an important contribu

285 Thus, loss of USH2A in corpuscular end-organs reduced mechanor

286 ty analysis revealed significant genome-wide losses of variation among the three stages and supports

287 d neointimal hyperplasia, diseases linked to loss of vascular smooth muscle differentiation.

288 n transient MLL1 inhibition caused a durable loss of ventral identity, resulting in the generation of

289 ntify synthetic lethal interactions with the loss of VHL through analysis of primary tumor genomic an

290 mild to severe, but many cause irreversible loss of viability.

291 ermeasures to IFN-I restriction, and genetic loss of viral IFN-I antagonists leads to virus attenuati

292 wer or 10 or more injections associated with loss of vision or a plateau, respectively.

293 the naive T cell compartment in mice, where loss of VISTA disrupted the major quiescent naive T cell

294 characterized by gradual-rather than sudden-loss of visual processing.

295 Loss of WASp impedes nuclear translocation of GOLPH3 and

296 the transcriptional repressor SPEN(1-3), the loss of which has been associated with deficient XCI at

297 Loss of Xrcc1, a major downstream effector of PAR, also

298 Loss of Yap in T cells results in enhanced T-cell activa

299 C14's importance for Kv1 channel clustering, loss of ZDHHC14 decreases outward currents and increases

300 Loss of ZNF410 in adult-type human erythroid cell cultur