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1 vity, phenotypes not observed with the eIF4G loss of function mutant.
2 activated by NaCl are absent from the Atann1 loss-of-function mutant.
3 tion mutant of PLN, whereas R14del is a mild loss-of-function mutant.
4 truncated rhBARF1 from clone 16 rhLCV was a loss-of-function mutant.
5 (BL)-insensitive phenotype similar to a bri1 loss-of-function mutant.
6 an avirulent bacterial pathogen in the bap1 loss-of-function mutant.
7 utant than to either wild-type I domain or a loss-of-function mutant.
8 to photoperiod in a manner similar to a cdf loss-of-function mutant.
9 l in vivo, as they complemented a yeast GLXI loss-of-function mutant.
10 ity phenotype was similar to that of the AS2 loss-of-function mutant.
11 he striking abnormalities of lin-4 and let-7 loss of function mutants.
12 naling, and this effect is blocked in usp-46 loss-of-function mutants.
13 show an increase in Lys acetylation in srt2 loss-of-function mutants.
14 e Dlx1/2 mutant phenotypes, we made compound loss-of-function mutants.
15 enient and effective approach for generating loss-of-function mutants.
16 altered in MPK6 overexpression lines or mpk6 loss-of-function mutants.
17 ctase were increased in rfd1 and the AUX/IAA loss-of-function mutants.
18 ly predicts root growth, as observed in bri1 loss-of-function mutants.
19 and root apical meristems observed in fbl17 loss-of-function mutants.
20 redundancy was confirmed through analysis of loss-of-function mutants.
21 ted nutations were also eliminated in etr1-7 loss-of-function mutants.
22 s a permissive temperature for wild-type and loss-of-function mutants.
23 ethality that often occurs in both gain- and loss-of-function mutants.
24 what E2F actually does based on analyses of loss-of-function mutants.
25 ina can often complicate the analysis of CBP loss-of-function mutants.
26 f and floral organ production in stm partial loss-of-function mutants.
27 erous breed-specific non-synonymous SNPs and loss-of-function mutants.
28 fect of ethanol, equivalent to that of slo-1 loss-of-function mutants.
29 d trunk mesoderm, and closely resemble nodal loss-of-function mutants.
30 e may be of interest to restore transport in loss-of-function mutants.
31 nted the observation of strong phenotypes in loss-of-function mutants.
32 ns, R205X and E239X, were shown to be Dyrk1a loss-of-function mutants.
33 th pathways was confirmed by the analysis of loss-of-function mutants.
34 creased cell migration beyond canonical PTEN loss-of-function mutants.
35 ark respiration was observed in the eIFiso4G loss of function mutant, a reduction in chlorophyll leve
36 as a promoter, may be mutagenized to isolate loss-of-function mutants able to survive under selection
37 ality of AtCDA in vivo was demonstrated with loss-of-function mutants accumulating high amounts of cy
39 Arabidopsis (Arabidopsis thaliana) quadruple loss-of-function mutant affecting p24 genes from the del
40 r show that removing MUL1 in PINK1 or parkin loss-of-function mutant aggravates phenotypes caused by
41 istant locomotory behavior, resembling slo-1 loss-of-function mutants, albeit to a lesser extent.
43 entifying EMB genes and characterizing their loss-of-function mutant alleles are needed to understand
49 of violaxanthin de-epoxidase in the eIFiso4G loss of function mutant and an increase in its xanthophy
51 catula development by isolating the lfl/wox3 loss-of-function mutant and performing genetic crosses w
53 ogen insensitivity syndrome (AIS)-associated loss-of-function mutants and 168 prostate cancer-associa
55 n of Pm5e was validated by transgenic assay, loss-of-function mutants and haplotype association analy
58 GR3, named CGR2, and evaluated the effect of loss-of-function mutants and over-expression lines of CG
61 validate genetic experiments performed with loss-of-function mutants and RNA interference (RNAi) lin
62 l fate and polarity, through the analysis of loss-of-function mutants and transgenic plants that ecto
63 riants conferring resistance to malaria are 'loss-of-function' mutants and appear to be recent polymo
64 isolated dominant-negative mutants, unc-108 loss-of-function mutant animals are defective in locomot
66 n oncogene and neuroprotective protein whose loss-of-function mutants are associated with certain typ
67 propose that the pleiotropic effects of dbf loss-of-function mutants are associated with the require
68 nd phenotypes of blh6, knat7, and blh6 knat7 loss-of-function mutants are consistent with the existen
71 d as having highly branched phenotypes, ccd1 loss-of-function mutants are indistinguishable from wild
75 present study, several gain-of-function and loss-of-function mutants as well as engineered mutants o
78 strates accelerated amyloidogenesis in Trem2 loss-of-function mutants at early stages, which progress
79 The method involves generation of partial loss-of-function mutants, at either buried or functional
80 eritability of Cas9 activity in heterozygous loss-of-function mutant backgrounds, to rapidly evaluate
81 er Myc mutants, MycDeltaMBIV is not a simple loss-of-function mutant because it is hyperactive for G2
83 axotomy, which is absent in ced-4 and ced-3 loss-of-function mutants but present in the ced-4(gf) mu
84 n of an AWC(ON) marker is initiated in nsy-7 loss-of-function mutants, but subsequently lost, so that
85 n wild-type maize and in the isogenic mop1-1 loss-of-function mutant by using Illumina's sequencing-b
86 action, we circumvented the lethality of keg loss-of-function mutants by silencing KEG using an artif
88 We report here characterization of a C-tail loss-of-function mutant, CF327A, and a related suppresso
89 have reduced FLC expression, but, unlike clf loss-of-function mutants, clf-59 mutants do not display
90 , although stomata of the Arabidopsis syp121 loss-of-function mutant close normally in ABA and high C
91 rs1-2 ers2-3 and triple etr2-3 ers2-3 ein4-4 loss-of-function mutants constitutively nutated in air.
92 ucose-fed conditions, the Arabidopsis sr45-1 loss-of-function mutant contains higher amounts of the e
94 ci appear to be "Myddosomes." The MyD88 S34Y loss-of-function mutant demonstrates how proper cellular
107 activity, but they all appear to manifest as loss-of-function mutants due to defects in solubility, a
110 -function ET receptor mutant, etr1-3, or the loss-of-function mutants etr1-7 and ers1-3 and the wild
112 associated with vascular tissues, while vup1 loss-of-function mutants exhibit collapsed morphology of
113 ted deletion of the cmpy locus and find that loss-of-function mutants exhibit excessive NMJ growth.
118 3 (GH43) family in Arabidopsis thaliana GH43 loss-of-function mutants exhibited root cell expansion d
119 the dominant act-5 mutation, or a recessive loss of function mutant, exhibited normal morphology and
120 similar to glh-1/glh-4(RNAi), the kgb-1(um3) loss-of-function mutant exhibits germline over-prolifera
121 root growth after Al exposure, because alt2 loss-of-function mutants fail to halt root growth after
126 This method can provide homozygous mammalian loss-of-function mutants for forward genetic application
128 planta by feeding [(3)H]serine to the WT and loss-of-function mutants for OAS-TLs in the cytosol, pla
129 onfers increased Al tolerance similar to the loss-of-function mutants for the cell cycle checkpoint g
130 n the North American monarch butterfly using loss-of-function mutants for the circadian activators CL
131 dendrites mimic ALA axon guidance defects in loss-of-function mutants for the extracellular matrix mo
132 te this issue, we produced a complete set of loss-of-function mutants for the three annotated Arabido
134 n297, Ala301, Phe307, and Tyr308 represented loss-of-function mutants; furthermore, the measurable re
136 d endoreplicating tissues in Drosophila gatA loss-of-function mutants grow slowly and never achieve w
140 ment from fertilization, the cyp78a8 cyp78a9 loss-of-function mutant has reduced seed set due to oute
145 tory molecules is wide-ranging, however, few loss-of-function mutants have been identified in miRNA g
147 ate earlier than the wild type, whereas etr2 loss-of-function mutants have increased sensitivity to A
150 eproductive and social behaviors, yet rodent loss-of-function mutants have relatively subtle behavior
151 recordings identified the R215H mutant as a loss-of-function mutant in inducing GABAergic synaptogen
154 natural ELF3 polyQ variants phenocopied elf3 loss-of-function mutants in a common reference backgroun
156 toperiod-dependent flowering in plants, with loss-of-function mutants in barley (Hordeum vulgare), le
161 rgan defects and indeterminacy that resemble loss-of-function mutants in E-function floral organ spec
162 ies converge on similar causes for olfactory loss-of-function mutants in evolutionary transitions to
163 te that the phenotypes associated with novel loss-of-function mutants in EXO70, are entirely consiste
164 Here, we report single and higher-order loss-of-function mutants in members of the cation/proton
168 dent in the embryonic epidermis of zebrafish loss-of-function mutants in the cognate Matriptase inhib
171 ole of tomosyn in neurosecretion we analysed loss-of-function mutants in the single Caenorhabditis el
173 rate that the gonadogenesis defects of gon-2 loss-of-function mutants (including a null allele) can b
174 psis resistance to Pst DC3000, whereas ADPG2 loss-of-function mutants increase the resistance to the
176 tantly, the BIG signature was reduced in Bmp loss-of-function mutants, indicating Bmp-regulated targe
177 sion was drastically reduced in beta-catenin loss-of-function mutants, indicating that Wnt signaling
179 The ABA hypersensitive phenotype of FyPP loss-of-function mutants is ABI5 dependent, and the amou
180 osmotic stress, while the growth of erf5erf6 loss-of-function mutants is less affected by stress.
181 h and show that their derepression in miR164 loss-of-function mutants is likely to account for most o
187 importance of Nisch, here we generated Nisch loss-of-function mutant mice and analyzed their metaboli
190 al prefrontal cortex (n = 21); and 4) a Nrg3 loss-of-function mutant (n = 59) to functionally implica
191 d-type FIT2, whereas FIT1 and a FIT2 partial loss-of-function mutant, N80A, had significantly lower t
192 ll three alleles are similar to those of the loss-of-function mutants obtained by RNA interference or
194 etion mutant of FOF2 (FOF2DeltaF), or double loss of function mutant of FOF2 and FOL1 (FOF2-LIKE 1) p
197 (GBP) interact with the N terminus of GluTR Loss-of function mutants of ClpR2 and ClpC1 proteins sho
198 ants of AGL15, alone or when combined with a loss-of-function mutant of a closely related family memb
202 rel map development using barrelless mice, a loss-of-function mutant of calcium/calmodulin-activated
208 expression phenotypes in overexpression and loss-of-function mutants of 15 Arabidopsis A-type heat-s
211 , we generated double, triple, and quadruple loss-of-function mutants of all four members of the RWA
212 n content and vein density were increased in loss-of-function mutants of Arabidopsis MYC2, a suppress
213 scriptional machinery during leaf senescence Loss-of-function mutants of Arabidopsis thaliana were us
217 we investigated the binding of A1 to GOF and loss-of-function mutants of GP Ibalpha with mutations in
221 imilar to the rgi1/2/3/4/5 quintuple mutant, loss-of-function mutants of MPK3 and MPK6, MKK4 and MKK5
222 or P. patens and facilitates the creation of loss-of-function mutants of multiple genes from differen
227 wed precocious flowering, whereas the triple loss-of-function mutants of SPL10 and its two homologous
228 cal neurons and impaired root hair growth in loss-of-function mutants of the ATL1 ortholog rhd3 in th
235 ysis of root phenotypes induced by gain- and loss-of-function mutants or in treatments with GLV-deriv
240 silencing in Drosophila embryos resulted in loss-of-function mutant phenotypes for 43 genes, which i
247 to freezing temperatures, whereas Atga2ox10 loss-of-function mutants produce considerably more seeds
248 es as either a recessive gain-of-function or loss-of-function mutant protein, depending on signaling
249 NA (mtDNA) in Arabidopsis thaliana Gain- and loss-of-function mutants provided evidence for a role of
253 e intestine and interneurons and that ehbp-1 loss-of-function mutants share with rab-10 mutants speci
255 AtSWEET2 sequesters sugars in root vacuoles; loss-of-function mutants show increased susceptibility t
257 plants with defective CIA components, grxs17 loss-of-function mutants showed some degree of hypersens
258 scopy of isolated lipid droplets from cgi-58 loss-of-function mutants showed they contain triacylglyc
259 istent enhanced collagen binding whereas the loss-of-function mutants showed variable degrees of func
263 on of a phoPR promoter-lacZ fusion in a scoC loss-of-function mutant strain grown in low-phosphate de
264 ant for Pan1p inhibition, and a pan1 partial loss-of-function mutant suppressed the temperature sensi
267 transferred into etr1-6;etr2-3;ein4-4 triple loss-of-function mutants that have constitutive growth i
272 fies cytosolic pH and NO(3) (-) In an AtCLCa loss of function mutant, the cytosolic acidification tri
277 ction of secondary roots are impaired in the loss-of-function mutant, thus identifying AtANN1 as a ke
278 as in vivo physiological studies in an LCI1 loss-of-function mutant to reveal the C(i) species prefe
282 ues the late-flowering phenotype of the gi-2 loss-of-function mutant under both short-day and long-da
283 erences in germination between etr1 and etr2 loss-of-function mutants under salt stress could not be
285 Consistent with these results, a Col-0 rfo1 loss-of-function mutant was more susceptible to f. matth
291 ting them in the respective four Arabidopsis loss-of-function mutants, we experimentally proved that
292 Using RNA interference (RNAi) to generate loss-of-function mutants, we show dramatic defects in ce
293 pressed AtLTPI-4 Crown galls of the atltpI-4 loss-of-function mutant were much smaller compared with
294 cumulation in wild-type roots, whereas Atao1 loss-of-function mutants were unresponsive to the hormon
295 psis plants expressing HaRxL44 and in med19a loss-of-function mutants, whereas SATI is elevated in pl
296 s found in the arr1-3 arr10-5 arr12-1 triple loss-of-function mutant, which showed almost complete in
299 this function was only apparent when double loss-of-function mutants with pp2ca-1/ahg3 were generate
300 evelopmental processes in situ by generating loss-of-function mutants within otherwise wildtype tissu