ライフサイエンスコーパス: low abundance

1 its availability is limited by the extremely low abundance.

2 ogenous muscle repair, due to their relative low abundance.

3 far undescribed structures, present at very low abundance.

4 led structural analysis of TPPII despite its low abundance.

5 ons from retina explants, and because of its low abundance.

6 protein allergen, Ara h 9, were detected in low abundance.

7 educing producers' ability to invade when at low abundance.

8 soil, but key decomposers are ubiquitous in low abundance.

9 persisted in the brain, albeit sometimes in low abundance.

10 ack of gamma2 subunit capture was not due to low abundance.

11 difficult to quantify in tumors due to their low abundance.

12 raftment of donor species, which remained at low abundance.

13 m core fucosylation in glycans detected with low abundances.

14 discrimination of overlapped ion peaks with low abundances.

15 found using this method were present in very low abundance (0.01-8 ppm), highlighting that our method

16 found in few flies; in contrast, despite its low abundance (2.9%), DNA from the Fabaceae family was d

17 cleotide small interfering RNAs (siRNAs) and low-abundance 22-nucleotide siRNAs produced from double-

18 tions were observed among the pipelines when low abundance AAVs are concerned, likely due to differen

19 While the sensitivity in detecting low abundance AAVs, with frequencies between 1~20%, is l

20 Dematin is a relatively low abundance actin binding and bundling protein associa

21 isualizing and spatially characterizing very low abundance analytes separated only by 20 mDa.

22 g proteomics tool capable of profiling >1000 low-abundance analytes with high sensitivity and high pr

23 duct ion scoring, which enables detection of low-abundance analytes with poor precursor ion signal.

24 Furthermore, we identified untargeted and low-abundance analytes, including neuropeptides deriving

25 ing and regulatory proteins are expressed at low abundance and are difficult to measure in single cel

26 singly, considering the subspecies' reported low abundance and density based on previous studies, we

27 Measurements of low abundance and heterogeneously distributed d-AAs in c

28 f challenges related to materials, including low abundance and high costs of redox-active metals, exp

29 enhanced proteome coverage, particularly for low abundance and high MW proteoforms.

30 While the low abundance and inability to enzymatically amplify DNA

31 blood is extremely challenging due to their low abundance and its account is clinically validated in

32 Evolved melts are in low abundance and large volumes of basalt flushing throu

33 ficant analytical challenge in view of their low abundance and low mutational load found in most prim

34 ared expression and shared structure despite low abundance and low sequence identity.

35 ying these cells is challenging due to their low abundance and poor recovery from tissues.

36 es and aryl isoprenoids) are present in very low abundance and pyrite framboids are absent.

37 des, studies so far have been limited by the low abundance and radioactivity, thus requiring huge sam

38 n-secreting alpha-cells is hampered by their low abundance and scattered distribution in rodent pancr

39 is challenging in part due to the relatively low abundance and short length of the miRNAs.

40 ing proteins is challenging because of their low abundance and the need for extensive enrichment.

41 ld explain general lncRNA properties such as low abundance and tissue specificity.

42 Amphidinium was always found in low abundances and was widely distributed among microhab

43 e the vesicular intermediates are transient, low-abundance and difficult to purify.

44 ectrometry imaging techniques in analysis of low-abundance and difficult-to-ionize sterol molecules,

45 Retaining low-abundance and dynamic subcellular structures or macr

46 Notably, TRPML channels are activated by the low-abundance and LEL-enriched signalling lipid phosphat

47 ncer, however, their promiscuous reactivity, low abundance, and short-lived nature limit our ability

48 ins challenging due to their low solubility, low abundance, and the complexity of the membrane subpro

49 a chromophore, the high charge density, the low abundance, and the instability of the esters and anh

50 eir unique physicochemical properties, their low abundance, and the lack of highly specific antibodie

51 d with mitochondrial disease, R-loops are of low abundance, and there is mitochondrial DNA aggregatio

52 We use the technique to isolate low abundance antibodies specific to different HIV antig

53 ventional diffusometry can be compromised at low-abundance antigens because proteins are much smaller

54 KIRs that were found at low abundance assembled into smaller clusters than those

55 -bound toxin and the convertases are of very low abundance at the cell surface.

56 Low-abundance ("background") sequence variants differed

57 ED) method that facilitates the detection of low abundance binders with high specificity and sensitiv

58 ofluorescence, and allowing the detection of low-abundance biomarkers in flow cytometry.

59 the potential for the sensitive detection of low-abundance biomarkers in living cells.

60 clude insufficient sensitivity for detecting low-abundance biomarkers, poor measurement reproducibili

61 ncrease the signal from the metals to detect low-abundance biomarkers.

62 etection of high-abundance glycerolipids and low-abundance but not less significant phospholipids in

63 eaked whale sightings is the result of their low abundance, but this is in contrast to our estimates

64 to automatically detect and annotate ions of low abundance by coupling blind data exploration strateg

65 vers or alpha-bugs) exert their influence at low abundance by modulating both the composition and lev

66 that only membranes allow identification of low-abundance CAII as a target.

67 utions are often overlooked because of their low abundance can have profound impact on cell architect

68 lity network specifying whether a species at low abundance can increase in frequency in an environmen

69 We demonstrate that the DBS method counts low abundance cell types such as immature reticulocytes

70 branes, binding to KRAS and NRAS mRNAs under low-abundance cell conditions.

71 Here, we report single-cell analysis for low abundance cells enabled by fluorescent droplet cytom

72 ge-specific accessible sites, especially for low-abundance cells, and connected the dynamics of promo

73 meter (TDI-SFC) for the immunophenotyping of low-abundance cells, particularly when cell counts are s

74 plication requiring the immunophenotyping of low-abundance cells, such as in monitoring measurable re

75 of-of-concept application to immunophenotype low-abundance cells; the demonstration consisted of immu

76 ) binds to RG4s in the KRAS transcript under low-abundance cellular conditions.

77 Despite their low abundance, chromatin mobility tracking shows that co

78 mer (i.e., phosphatidylglycerol, PG, another low-abundance class of phospholipids).

79 cylglycero)phosphate (BMP), an important but low-abundance class of phospholipids, has been hindered

80 amine (PE)) and enhance the signals from the low-abundance CLs and gangliosides to allow their GCIB-S

81 d from community rRNA revealed that diverse, low abundance community members may play important roles

82 izing the receiving ecosystem, but mostly as low abundance community members.

83 irculating rare cells due to their extremely low abundance compared to hematologic cells.

84 CNGC19, the closest homolog of CNGC20 with a low abundance compared with CNGC20, makes a quantitative

85 Native RUP1 is present in low abundance compared with RUP2.

86 The 11 strains primarily represent rare, low-abundance components of the human microbiome, and th

87 lure to address batch-specific truncation of low abundance compounds.

88 revealed the presence of multiple clones of low abundance, confirming the polyclonal expansion of HT

89 n provide new insights into diagnosing other low-abundance diseases in the future.

90 to different forms of DNA damage, including low-abundance DNA adducts induced by reactions with elec

91 he sensitivity of nucleic acid detection for low-abundance DNA biomarkers.

92 erous investigations, the clinical impact of low-abundance drug-resistant HIV-1 variants (LA-DRVs) at

93 rasensitivity in monitoring trace amounts of low-abundance early biomarkers or environmental toxins,

94 le isolation and identification of extremely low abundance endogenous analytes present within complex

95 htly controlled recruitment of telomerase, a low-abundance enzyme, to telomeres is essential for regu

96 tructing the investigations of important but low abundance epimers in isomeric mixtures.

97 rentially bind and stabilize the short-lived low-abundance ES relative to the long-lived more abundan

98 ch that the native GS conformation becomes a low-abundance ES.

99 xist in dynamic equilibrium with short-lived low-abundance 'excited states' that form by reshuffling

100 urification and mass spectrometry identified low-abundance exosome-associated proteins and protein co

101 al challenge in complex matrices, due to the low abundance, extensive suppression during MS analysis,

102 , limiting the ability to reliably visualize low-abundance fluorescent proteins.

103 MM SEC allows quantitative detection of even low abundance forms and provides a new tool for screenin

104 isolation and selective ion accumulation for low abundance fractions revealed over 3 times more molec

105 larly well suited for the rapid detection of low-abundance fungal pathogens and identification of the

106 t of the diversity in ITS surveys represents low-abundance fungi possibly acquired from the environme

107 ategies are designed for the pretreatment of low-abundance glycans and glycopeptides prior to mass sp

108 or the difficult-to-detect early eluting and low-abundance glycans detached from N- and O-glycoprotei

109 xtensive metabolome coverage, especially for low-abundance glycerophospholipids and sphingolipids.

110 It is especially difficult to study low abundance groups where very little biological inform

111 ch precludes the effective identification of low abundance HCPs in antibody product.

112 igh abundance biopharmaceutical proteins and low abundance HCPs.

113 m high-abundance homodimers and Pi-regulated low-abundance heterodimers.

114 e-molecule readout could distinguish between low-abundance, high-affinity (specific analyte) and high

115 rehensive profiling of scarcely investigated low-abundance histone marks, revealing that concentratio

116 f next-generation sequencing (NGS) to detect low-abundance HIV-1 variants.

117 al for the improved sensitivity in detecting low-abundance homodimer impurities (LOD from 0.01% to 0.

118 However, sensitive detection of low-abundance homodimer impurities can still be challeng

119 microfluidic method to identify and quantify low-abundance IgG N-glycans and show some of these IgGs

120 ce of numerous structural isomers, and their low abundance in biological samples.

121 Despite its low abundance in eukaryotes, m6dA is implicated in human

122 Despite their low abundance in gut microbiomes and restricted phylogen

123 bacterial species, which are only present in low abundance in health and a proportionate decrease in

124 o be adequately explored, largely due to its low abundance in most mammalian genomes.

125 vely recent intruder in whiteflies given its low abundance in the field and relatively larger genome

126 The sensitivity of pH to soluble elements in low abundance in the host rocks, such as carbon, alkali

127 e "enriched" sequences that are absent or of low abundance in the other tissue.

128 o study, because the distorted DNA exists in low abundance in the unbound ensemble(3-9).

129 undant bacteria that were undetectable or at low abundance in their diet.

130 theless, the expansion of multiple clones of low abundance in these humanized mice mirrors the early

131 single radial glia cells but is detected at low abundance in tissues.

132 igh volatility and incompatibility, but have low abundances in most geological and planetary material

133 rial cultures and absent (or present at only low abundance) in control samples indicating that these

134 filing of neuropeptides, especially those in low abundance, in a variety of sample types.

135 RNA-proteomic method that enables probing of low-abundance interactions and an allelic RNA-depletion

136 crimination by multivariate methods based on low abundance ions.

137 d and demonstrated for the enrichment of the low abundance ions.

138 was barely reduced indicating that CTRL is a low-abundance isoform.

139 f six previously unidentified and comparably low-abundance LD proteins, each of which was confirmed b

140 ternative mechanism might better explain how low-abundance lncRNAs transcribed from noncoding DNA fun

141 viable oral mycobiome members, although the low-abundance Malassezia sympodialis was the only Malass

142 antify cell-type frequencies in tissue using low-abundance marker genes.

143 ped a data-preprocessing pipeline to extract low-abundance metabolic features and integrate them with

144 programs present limitations in recognizing low-abundance metabolic features, thus hindering complet

145 er sensitivity than SRV to detect peaks from low-abundance metabolites.

146 f the raw mass spectrometry data, especially low-abundance metabolites.

147 using TMT labeling enabled the detection of low-abundance MHC I peptides including tumor-specific an

148 followed by (b) transformation into TMA via low-abundance microbiota in omnivores, and to a markedly

149 Nowadays, it is still a challenge to detect low-abundance miRNAs.

150 The detection and quantification of low-abundance molecular biomarkers in biological samples

151 lso contribute to faster detection times for low abundance molecules in small sample volumes.

152 alternative to current procedures to detect low abundance molecules.

153 imation of oligomeric distributions, so that low abundance monomers display a much higher apparent ab

154 ncation variants and a previously unreported low-abundance monoprotomer.

155 However, its detection within low-abundance mRNAs and microRNAs (miRNAs) has been hamp

156 e, we present a fluorescence-based assay for low-abundance mutation detection based on toehold-mediat

157 ew assay accurately detected DRMs, including low-abundance mutations that were often missed by Sanger

158 YscRNA-seq detects the expression of low-abundance, noncoding RNAs and at least half of the p

159 and mouse tissues to investigate changes in low-abundance nuclear and cytoplasmic proteins following

160 This low abundance of (236)U and the presence in large excess

161 metals, relatively high values of quartz and low abundance of arsenates, (iv) sites 13-14 (also in ce

162 a during infection is challenging due to the low abundance of bacterial mRNA.

163 lyses in transgenic lines revealed extremely low abundance of CgCOM1 transcripts in the C. gloeospori

164 cross-link detection is often limited by the low abundance of cross-links compared to non-cross-linke

165 ne; however, this strategy is limited by the low abundance of cysteine and acquired drug resistance f

166 ed cysteine residues as nucleophiles but the low abundance of cysteine in the proteome has limited it

167 y fluorophores conferred by their relatively low abundance of distribution in the kidney limits their

168 We detected a low abundance of HHV-6-specific CD4 T cells in blood; ho

169 ired for maintenance of DNA methylation, and low abundance of histone transcripts involved in heteroc

170 Bacterial vaginosis (BV) is characterized by low abundance of Lactobacillus species, high pH, and imm

171 (LiLPPS), thus accounting for the relatively low abundance of LPP-derived irregular monoterpenes in t

172 nal shotgun proteomics, probably due to very low abundance of native sulfoproteins, poor ionization e

173 Low abundance of potential pathogens was detected by 16S

174 Piperacillin-tazobactam was associated with low abundance of potentially protective taxa (eg, Lactob

175 AH1206 engraftment was associated with low abundance of resident B. longum and underrepresentat

176 gainst higher organisms, the high price, and low abundance of silver.

177 The minute sample volumes and low abundance of some constituents in cells hinder our u

178 obial capacity for bile acid conversion, and low abundance of some species involved in saccharolytic

179 The protective microbiota had a low abundance of Streptococcaceae relative to outdoor-as

180 hate is thought to be limited in part by the low abundance of the critical micro-nutrient iron.

181 lexity of the poly(ADP-ribose) (PAR) chains, low abundance of the modification and lack of sensitive

182 sient nature of these contacts and the often low abundance of the participants present significant ex

183 higher levels of uncoupling protein 1 and a low abundance of the proinflammatory interleukin-6, a co

184 lly, we show that S. sanguinis Tfp contain a low abundance of three additional proteins processed by

185 or the class conversion model explaining the low abundance of U12-type introns in modern genomes.

186 The low abundance of VZV nucleic acids in human neurons has

187 e and even communities, with correspondingly low abundances of 'Ca.

188 s on the order of years, suggesting that the low abundances of amino acids in Tagish Lake cannot be a

189 The low abundances of Ir and Ru in the earth's crust and, he

190 on is extraordinarily challenging due to the low abundances of many O-GlcNAcylated proteins and the c

191 Consequently, relatively low abundances of small particles are predicted at the o

192 he CI deficiency concomitantly occurred with low abundances of the mtDNA transcription factors TFAM a

193 decipher specific kinase target proteins of low abundance, of transient phosphorylation, or in yet-u

194 s potential for enhancing the sensitivity of low abundance or targeted species.

195 ularly in their predilection for identifying low-abundance or contaminant organisms as present.

196 and MAT3/RB, we postulate the presence of a low-abundance or transient regulatory complex in C. rein

197 Low-abundance oral mycobiome members acquired from the e

198 fic chromosomes from the human genome and of low-abundance organisms in mixed populations without a p

199 Detection of low abundance pathogen sequences remains a challenge for

200 ensitive, rapid, and specific tool to detect low-abundance PC clones in BM and assign them to POEMS s

201 f the selected precursor can be removed, and low abundance peaks that are believed to have limited co

202 23%, and 34% for high, medium, low, and very low abundance peaks, respectively.

203 The detection limit of Western blot for low-abundance PEGylated interferon (Pegasys) and recombi

204 Model low abundance peptides covering a wide range of hydropho

205 e effective sampling and characterization of low abundance peptides derived from the antigen-binding

206 ol and surface-capture low-molecular-weight, low-abundance plasma proteins that cannot be detected by

207 Low-abundance populations with high intra-population div

208 However, precise quantification of extremely low abundance proteins (e.g., </= 100 pg/mL in blood pla

209 42 low abundance proteins and 46 high abundance proteins in

210 col enables the discovery of interactors for low abundance proteins in rice and opens the possibility

211 at promise for precisely measuring extremely low abundance proteins or protein modifications, especia

212 Isolation of low abundance proteins or rare cells from complex mixtur

213 hoto-stability, making the detection of very low abundance proteins using fluorescent protein-based m

214 coral isolate, showed that a large number of low abundance proteins were exclusively detected in OMVs

215 ies often prevent the detection of PPIs with low abundance proteins.

216 This immunoassay protocol makes thousands of low-abundance proteins accessible to quantitative measur

217 tiplexed in-gel immunoassays, including that low-abundance proteins be immunoprobed first, even when

218 orm that enables single-molecule counting of low-abundance proteins by mechanically slowing-down thei

219 y enable the proteoform-resolved analysis of low-abundance proteins directly from serum to reveal pre

220 However, the MS detection of low-abundance proteins from blood remains an unsolved ch

221 analysis, which often render the analysis of low-abundance proteins impossible.

222 ced and identification of newly synthesized, low-abundance proteins is challenging.

223 nt when applied to the isolation of multiple low-abundance proteins or cell types.

224 improvements make possible the detection of low-abundance proteins present at sub-attomolar levels,

225 orescent proteins (FPs) in E. coli, allowing low-abundance proteins to be counted using standard tota

226 ethods for proteins, the immune-detection of low-abundance proteins using antibodies is fundamentally

227 Analyzing the spatial distribution of low-abundance proteins within cells is highly challengin

228 This method is especially advantageous for low-abundance proteins, a significant limitation of many

229 stigating proteome changes, particularly for low-abundance proteins, in different biological matrices

230 te heavily to sample loss, in particular for low-abundance proteins.

231 suggest that degradation is limited to a few low-abundance proteins.

232 ultrasensitive detection systems to measure low-abundance proteins.

233 abundance require tailoring to penetrate to low-abundance proteins.

234 FP repeats, critically enabling the study of low-abundance proteins.

235 MW proteins up to 223 kDa and also revealed low abundance proteoforms that are post-translationally

236 k, we first developed a new method to detect low-abundance PSVs with improved sensitivity.

237 plicated by limited amounts of purified EVs, low-abundance PTM proteins, and interference from protei

238 enrichment to achieve sensitive analyses of low-abundance PTMs in EVs isolated from 1 mL of plasma.

239 abundant, high strain variation genomes, and low-abundance, rare genomes.

240 s, imaging short-lived forces transmitted by low-abundance receptors remains a challenge.

241 Here, triggering of low-abundance receptors resulted in less phosphorylation

242 Importantly, mRNAs encoding low-abundance regulatory proteins tend to be enriched in

243 the signal transduction pathway owing to its low abundance relative to its binding partners.

244 chococcus and Cyanobium) with a long tail of low abundance representatives, and local peaks of bloom-

245 cumulation and 3' end misprocessing of other low-abundance RNAs, including those encoding cilia compo

246 s and focused in vivo investigations of even low-abundance RNAs.

247 ease until they equal the influx rate of the low abundance sample species.

248 eby restricting responses to low-affinity or low-abundance self-antigens even in the context of an in

249 We introduce FLASH (Finding Low Abundance Sequences by Hybridization), a next-genera

250 horylates phytic acid (InsP6) to produce the low abundance signaling molecules InsP7 and InsP8.

251 horylated phosphoinositide lipids (PPIs) are low-abundance signaling molecules that control signal tr

252 of highly sensitive and specific assays for low-abundance signaling proteins.

253 suggests that lower female recruitment into low abundance sites is contributing to these skews.

254 The detection and quantification of low-abundance somatic DNA mutations by high-throughput s

255 ain in its entirety enabled the detection of low abundance, spatially-heterogeneous lipids associated

256 functions of antibody-based drugs; however, low-abundance species are difficult to detect.

257 ate that these exceptionally short-lived and low-abundance species form Watson-Crick-like base pairs,

258 synthesis remains reliant upon reactive and low-abundance starting materials.

259 ng N deprivation, suggesting the presence of low abundance subcomplexes containing CHT7 and MAT3/RB.

260 Surprisingly, a low-abundance subset of SECs containing ELL2 and AFF1 wa

261 cific miRNAs, some with few target genes and low abundances, suggests their recent evolutionary origi

262 ngle cells, including the ability to amplify low-abundance tags to make them detectable with sequenci

263 the capacity of PICs to efficiently deplete low-abundance target bacteria without significant collat

264 e various immunoassays to sensitively detect low-abundance target molecules by just mixing their dete

265 quivalent proficiency, revealing hundreds of low-abundance targets missed by previous approaches.

266 ore increase the proportion of NGS reads for low-abundance targets.

267 rescence states for multiplexed detection of low-abundance targets.

268 ften had low relative abundances, suggesting low-abundance taxa may significantly contribute to rhizo

269 of greater taxonomic diversity-including of low-abundance taxa-with better metagenome-assembled geno

270 identified endogenous Enterobacteriaceae, a low-abundance taxon, as a keystone species responsible f

271 KIRs that were more highly abundant, and at low abundance, there was a greater proportion of KIRs in

272 at our method has the ability to detect both low abundance tissue-annotated proteins and phosphorylat

273 ye fluorescence and permits visualization of low-abundance tissue markers such as Bcl-6 or MSH-6.

274 suited for cell-type-specific studies using low-abundance tissues.

275 eic acid-based methods to successfully image low-abundance TR in living cells.

276 ecisely quantify these previously undetected low-abundance, trace and even ultra-trace N-glycans.

277 rectly assay the O-GlcNAcylation status of a low-abundance transcription factor from cell lysates wit

278 efficient rRNA removal enhanced detection of low abundance transcripts via qPCR.

279 were able to identify transcripts, including low abundance transcripts, in specific cell types.

280 Detection of low-abundance transcripts by 10cRNA-seq is comparable to

281 was deep enough to enable identification of low-abundance transcripts such as G-protein-coupled rece

282 in interpreting the results of scRNASeq for low-abundance transcripts such as the incretin receptors

283 l transcripts, detects nonpolyadenylated and low-abundance transcripts, and can profile more than 100

284 anscriptome is remarkably complex, including low-abundance transcripts, many not polyadenylated.

285 ing other trends in the single-cell data for low-abundance transcripts.

286 hile increasing the stability of a subset of low-abundance transcripts.

287 y other amino acid-increases selectivity for low-abundance transition metal transport in the presence

288 This sSNP introduces a codon pairing to a low-abundance tRNA that is particularly rare in human br

289 Low-abundance tRNAs decode rare codons slowly, but it is

290 Low-abundance tRNAs might promote optimal protein foldin

291 A low-abundance, truncated AAT protein was confirmed in pl

292 Low-abundance tyrosine phosphorylation is crucial to not

293 d by PANDAA, only 6 (29%) were identified as low-abundance variants by NGS.

294 nly a few opportunistic pathogenic groups of low abundance were associated with AL in C-seal patients

295 ds in human serum, where uncommon isomers of low abundance were quantified for the first time.

296 Our data illustrate that taxa driven to low abundance when dietary MACs are scarce are inefficie

297 e-biased sites are more frequent in areas of low abundance, which are now widespread across much of s

298 aks from an enriched metabolite tend to have low abundances, which makes liquid chromatography tandem

299 were exploited to improve the enrichment of low-abundance yeast cells in an iDEP channel.

300 have the potential to aid the enrichment of low-abundance yeast cells when filler volume fractions a