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1 r into a moderate PI3Kalpha inhibitor with a low molecular weight.
2 ect exchange of intracellular molecules with low molecular weights.
3 trated that our method could detect HCP with low molecular weight (11 kDa and 17 kDa) at a concentrat
4 llows the direct detection of bisphenol A, a low molecular weight (228 Da) target usually detectable
7 itively regulated by adjusting the dose of a low molecular weight adapter that must bridge between th
8 eaction to a variety of organic materials or low molecular weight agents that are present in the work
9 te-specific membrane antigen (PSMA)-targeted low-molecular-weight agents for (212)Pb-based TRT of pat
11 tem, which showed improved responsivities to low molecular weight alcohols compared to similar sensor
13 des, lipids, lignin, carbohydrates, and some low-molecular-weight aliphatic and aromatic compounds) a
16 mpounds would be an ideal tool for screening low-molecular weight analytes (<2000 Da) having many var
17 rations of thrombin (10(-18) m) as well as a low molecular weight anatoxin (165 Da, 10(-14) m) are de
18 isomerization in heptane and a PAO show that low molecular weight and oligomeric carboxylic acids are
19 ead of Tau pathology, and by virtue of their low molecular weight and relative solubility, oligomers
20 Frankia CcI3 supernatant are hydrophilic, of low molecular weight and resistant to chitinase degradat
22 rapolating from lessons learnt with previous low-molecular-weight beta-(1->3)-glucan mimetics, we des
23 statistical differences have been found for low-molecular-weight biocompounds, PEGs, and nonhydropho
25 employment of independent variables such as low molecular weight carbohydrates (LMWC), soluble solid
27 stead, fragmentation produces polyfunctional low molecular weight carboxylic acids after oxidative cl
28 eptor-targeted radiopharmaceuticals based on low-molecular-weight carriers offer many clinically adva
36 nalyses was used to determine changes in the low-molecular-weight compound composition of peanuts due
37 sly, we synthesized a beta-particle-emitting low-molecular-weight compound, (177)Lu-L1 which demonstr
39 most efficient method in terms of yields of low molecular weight compounds (in particular chlorogeni
40 ion, and decarboxylation, and (ii) releasing low molecular weight compounds and inorganic nutrients f
41 ed drug design exploits initial screening of low molecular weight compounds and their concomitant aff
42 even quantify the minute amounts of secreted low molecular weight compounds produced by living and is
44 in juices was five times lower than that of low molecular weight compounds, while the transfer of hi
46 ate a particularly high capacity for loading low-molecular weight compounds and even folded proteins.
47 olomics to perform quantitative profiling of low-molecular weight compounds from biological specimens
48 MS was found to provide enhanced coverage of low-molecular weight compounds such as amino acids, wher
51 fermentation, with a concurrent increase in low-molecular-weight compounds (hydroxybenzoic and hydro
54 oduced for measuring the binding kinetics of low-molecular-weight compounds to their biomolecular tar
55 ponsible for chain transfer and formation of low molecular weight copolymers in the traditional catal
56 nitrification, is prone to the production of low-molecular-weight dissolved organic N (LMW-DON), whic
58 easily included to modulate the transport of low molecular weight drug-like entities through the netw
60 udomonas aeruginosa quorum-sensing-regulated low-molecular-weight excreted molecule, triggers autolys
62 Obesity increased BBB permeability to the low molecular weight fluorophore sodium fluorescein (NaF
63 ytes, JARID2 predominantly exists as a novel low molecular weight form, which lacks the N-terminal PR
65 e digest showed that the iron was present in low molecular weight fractions which contained glucose,
67 IP) to identify and map the binding sites of low molecular weight fragments that engage RNA or Chem-C
69 kinetics, but only one of the formulations (low molecular weight, free acid terminated) exhibited th
70 ructure on supramolecular gels, we combine a low-molecular-weight gelator (LMWG) with the polymer gel
74 Hydrogels formed by the self-assembly of low-molecular-weight gelators (LMWGs) are promising scaf
75 he addition of gluten, glutenin and purified low molecular weight glutenin subunits (LMW-GS) using a
76 t in a single wheat line lowered gliadin and low-molecular-weight glutenin accumulation by 50% to 60%
77 tion of extracellular HA and accumulation of low molecular weight HA (LMW-HA) in tumor tissue was ass
79 this study, we screened several inexpensive, low-molecular-weight haloalkanes as blocking agents in p
80 to potable quality have difficulty removing low molecular weight halogenated disinfection byproducts
85 agulants (DOACs) may be good alternatives to low molecular weight heparin (LMWH) or vitamin K antagon
87 eatments included substitution of heparin or low-molecular weight heparin for warfarin (n = 13 [72%])
88 nous thromboembolism previously treated with low-molecular weight heparin, fondaparinux, or a vitamin
89 ts did not differ from that with warfarin or low-molecular-weight heparin (factor Xa vs warfarin IRR
90 ned to receive either a prophylactic dose of low-molecular-weight heparin (for the 8 days after arthr
92 ada, since 2006, involved replacing UFH with low-molecular-weight heparin (LMWH) for prophylactic and
93 with a higher risk of bleeding compared with low-molecular-weight heparin (LMWH) in patients with GI
94 partum period is not above a threshold where low-molecular-weight heparin (LMWH) prophylaxis is clear
95 K antagonist (VKA) throughout pregnancy; 2) low-molecular-weight heparin (LMWH) throughout pregnancy
96 is of randomized controlled trials comparing low-molecular-weight heparin (LMWH) vs no LMWH in women
97 ic thromboprophylaxis with unfractionated or low-molecular-weight heparin (pneumatic compression grou
98 vs dabigatran 0.88 [0.59-1.36]; factor Xa vs low-molecular-weight heparin 1.02 [0.42-2.70]; and low-m
100 that compared direct oral anticoagulant with low-molecular-weight heparin are also summarised, along
101 d with hydroxychloroquine, azithromycin, and low-molecular-weight heparin at anticoagulant dose.
102 r than conventional anticoagulation therapy (low-molecular-weight heparin followed by vitamin K antag
104 tal venous thromboembolism to receive either low-molecular-weight heparin for at least 5 days followe
105 s of our trials showed that prophylaxis with low-molecular-weight heparin for the 8 days after knee a
106 icoagulants have been recently compared with low-molecular-weight heparin for the management of acute
107 dditional clinical trials of edoxaban versus low-molecular-weight heparin for the treatment of venous
109 of 10 431 participants; 4139 included in the low-molecular-weight heparin group and 4139 in the contr
110 58 (4.0%) of 3958 with available data in the low-molecular-weight heparin group compared with 279 (7.
111 the control population and 88 (2.1%) in the low-molecular-weight heparin group, and minor bleeding e
114 bivalirudin monotherapy vs unfractionated or low-molecular-weight heparin plus optional GPIs (control
115 monotherapy compared with unfractionated or low-molecular-weight heparin plus optional GPIs on 1-yea
117 lecular-weight heparin 1.02 [0.42-2.70]; and low-molecular-weight heparin vs dabigatran 0.67 [0.20-1.
118 itial treatment with unfractionated heparin, low-molecular-weight heparin, or fondaparinux, usually o
120 now prefer full-dose oral Xa inhibitors over low-molecular-weight heparin, with gastrointestinal lesi
127 in binding of various glycosaminoglycans and low molecular weight heparins by microscale thermophores
129 ompared the efficacy and safety of DOACs and low-molecular-weight heparins (LMWHs) in these patients.
136 erface and by targeting the interface with a low molecular weight inhibitor, we show that TNFalpha re
137 successful, structure-guided development of low molecular weight inhibitors specifically and selecti
138 acologically more favorable approaches using low-molecular-weight inhibitors has been hampered by low
139 y used as alternate matrices to minimize the low molecular weight interferences observed in typical M
140 MALDI imaging mass spectrometry (IMS) of low molecular weight ions is particularly challenging as
142 ore, intact G1/S transition (Rb-positive and low-molecular-weight isoform of cyclin E (cytoplasmic)-n
143 ange -2.5) and concomitant increase in their low molecular weight isoforms (mean fold-change 6.4 and
145 variants progressively yielded smaller-sized low-molecular-weight levans, as the affected subsites th
149 e model allowing us to assemble a library of low-molecular-weight ligands predicted to bind the SAS-6
150 in labile pools, defined as loosely bound to low-molecular-weight ligands, which can regulate diverse
152 o clad conventional monofilament fibers with low-molecular-weight liquid crystals (LCs) stabilized by
153 in high yields (up to 80 weight percent) to low-molecular-weight liquid/wax products, in the absence
154 in (Ig)-E in occupational asthma (OA) due to low molecular weight (LMW) agents is not well establishe
157 nvestigate the persistence of (14)C-labelled low molecular weight (LMW) DOC at a wide range of concen
159 n of Maillard reaction (MR), induced between low molecular weight (LMW) peptides and sucrose, was stu
162 ns, associates with an elevated abundance of low molecular weight (LMW) thiols, including glutathione
165 LABs were used to produce breads from which low molecular weight (LMW-) peptides were extracted.
166 Most of the abundant PAHs identified were low molecular weight (LMW-PAH) (liver > muscle) with 2-3
167 ct that was then fractionated for elution of low-molecular weight (LMW) and high-molecular weight (HM
170 t into the periplasm, such that little to no low-molecular weight (LMW) products are externally relea
172 High-molecular-weight (HMW) proteins and low-molecular-weight (LMW) chemicals can cause occupatio
173 and the commonly administered anticoagulant, low-molecular-weight (LMW) heparin, in the initiation an
174 on of S-nitrosothiols, including protein and low-molecular-weight (LMW) S-nitrosothiols (S-nitroso-GS
175 activated without apparent dissociation into low-molecular-weight (LMW) species after RNase A treatme
176 ly the nonconserved Cys-127 reacted with the low-molecular-weight (LMW) thiol mycothiol, protecting i
178 scavenge the blood pool and surface-capture low-molecular-weight, low-abundance plasma proteins that
179 Here, we present the proteome profiling of low-molecular weight (<50 kDa) proteins of seven differe
180 viral ligand polyinosinic-polycytidylic acid-low-molecular-weight/LyoVec and LPS to evaluate IFN-alph
182 Here, we use MALDI timsTOF IMS to image low molecular weight metabolites at higher spatial resol
183 this improved sensitivity, we have found >40 low molecular weight metabolites in human kidney tissue,
184 relation between sweat and blood considering low-molecular weight metabolites is even better than tha
187 bolite measures: 51 lipids, fatty acids, and low-molecular-weight metabolites; 98 lipid composition a
189 e-radical polymerization of water-insoluble, low-molecular-weight monomers that show a large change i
190 organically bound iodine (org-(129)I) with a low molecular weight (MW) range (0.5-5 kDa) in all soils
191 he R(ee) landscape by measuring P(R(ee)) for low molecular weight (MW: 0.22-2.6 kDa) dilute PEO chain
194 These results establish the advantage of low molecular weight, narrow polydispersity, and amorpho
195 mpetitive immunoassays, for the detection of low molecular weight natural toxicants, as an alternativ
196 a model, batch FO experiments concluded that low molecular weight neutral compound transfer is depend
197 mbrane process that can selectively separate low molecular weight neutral compounds such as ammonia f
198 aimed to determine the transport behavior of low molecular weight neutral nitrogen compounds in order
199 ntaminants and the insufficient rejection of low-molecular-weight neutral organics by RO calls for th
200 coefficients by fragmenting the structure of low-molecular-weight neutral organics into small parts t
201 mall molecules and antibodies by combining a low molecular weight of about 2 kDa with an antibody-lik
202 depth of the SAR, as well as the relatively low molecular weight of the series, suggests, but does n
203 cape model, we predict the structures of the low-molecular weight oligomeric form and the dynamics of
204 led to their quantitative dissociation into low molecular weight oligomers ( approximately 8-70 kDa)
205 into low molecular weight species, and these low molecular weight oligomers are significantly more bi
208 n states, which result from the formation of low molecular weight oligomers, high molecular weight ol
212 s the purification and the identification of low molecular weight oligosaccharides contained in an Et
216 lved organic matter (DOM) into inorganic and low-molecular-weight organic products, contributing to i
218 We report a functionally unique family of low-molecular-weight PBPs that act as transpeptidases ra
219 ses that form peptidoglycan cross-links, and low-molecular-weight PBPs, which are typically hydrolase
220 el and convenient approach to generate ultra-low molecular weight pectin with high efficiency and hig
221 dings indicate that precise modifications of low molecular weight PEI improve its bio-responsiveness
222 w value source to produce highly digestible, low molecular weight peptide powders that could be used
224 seed expeller demonstrated an enrichment of low molecular weight peptides (molecular weight <15 kDa)
230 ated DI (RDI) and one sustained (SDI) on the low molecular weight phenolics together with the antioxi
231 gation revealed differential accumulation of low-molecular-weight phenolics, including (glycosylated)
232 s study aims to investigate the stability of low molecular weight phlorotannin fractions from Fucus v
233 their cognate histidine kinases but also by low molecular weight phosphodonors such as acetyl phosph
234 er prenatal concentrations of metabolites of low-molecular weight phthalates (SigmaLMW) were associat
235 core [e.g., B per 10-fold increase in summed low-molecular weight phthalates = - 1.7 (95% CI: - 3.1,
236 temperature and pH) to reduce gallic acid, a low molecular weight pigment (MW 170gmol(-1)) widely fou
237 an efficient method to reduce the potential low molecular weight pigment present in the sugarcane.
238 extend our previous work on phosphorescent, low molecular weight platinum(II) complex as an oxygen s
239 n particulate matter (PM) and the associated low molecular weight polycyclic aromatic hydrocarbons (P
240 (Ad-SS-GD) with beta-cyclodextrin-conjugated low-molecular-weight polyethyleneimime (CP) through supr
241 Conversely, extraction with KOH 25% provided low molecular weight polysaccharides with substantially
242 The use of KOH 2% increased the amount of low molecular weight polysaccharides, resulting in bimod
246 3 distinct protease activities in the LMP2 (low-molecular-weight protein 2), LMP7 (low-molecular-wei
247 LMP2 (low-molecular-weight protein 2), LMP7 (low-molecular-weight protein 7), and MECL1 (multicatalyt
248 growth medium demonstrated the presence of a low molecular weight proteinaceous secreted factor that
249 -IR) spectroscopy to detect and quantify the low-molecular-weight proteinaceous components of blood s
250 time-of flight (TOF) proteomics to identify low molecular weight proteins that associated with poor
251 ght proteins and correlated only weakly with low molecular weight proteins, suggestive of tubular pro
252 ricity and present massive urinary losses of low-molecular-weight proteins and albumin, caused by sel
254 result in the production and accumulation of low-molecular-weight proteins in the urine and systemic
255 concentrations of amino acids, peptides, and low-molecular-weight proteins present in serum samples.
257 l Ocrl-knockout mouse background resulted in low molecular weight proteinuria, phosphaturia, and acid
258 (PT) dysfunction typically characterized by low molecular weight proteinuria, renal tubular acidosis
259 ensive overview of the current literature on low-molecular-weight PSMA ligands for both PET imaging a
263 e broadly, this work suggests that flexible, low-molecular-weight sequence-defined polymers can serve
264 s and evaluation of the first, high-affinity low molecular weight Siglec-7 ligands to interfere with
265 cal pretreatments to extract and concentrate low molecular weight SMPs (MW< 580 Da) from effluents we
266 iols (SNOs) in proteins and small molecules (low-molecular-weight SNOs) whose levels are regulated by
269 technology is generally limited to releasing low molecular weight species that can diffuse through th
270 the abundant HMW oAbeta can dissociate into low molecular weight species, and these low molecular we
274 of essential elements present in the form of low-molecular weight stable complexes known for their bi
275 mers are rationally designed from relatively low-molecular-weight starting materials, with the degree
276 bstrate-based approach to the development of low molecular weight STEP inhibitors with Ki values as l
277 gradation of acrylamide (AA), asparagine and low molecular weight sugars were evaluated during an ind
278 structure, reported for the self-assembly of low molecular weight surfactants, for example, lipids, b
280 s have largely focused on the development of low-molecular-weight, synthetic BH3 mimetics ("magic bul
285 between a protein cysteine and an attacking low molecular-weight thiol have a dramatic effect on the
286 that reported for the reaction with the main low-molecular-weight thiol in M. tuberculosis, mycothiol
287 E-SSH could transfer its sulfane sulfur to a low-molecular-weight thiol, a process likely facilitated
289 k, we examined the reactions of NO2-CLA with low molecular weight thiols (glutathione, cysteine, homo
290 lated and S-cysteinylated peptides, in which low molecular weight thiols are attached to cysteine res
291 7 cells, including elevated abundance of the low molecular weight thiols coenzyme A (CoA) and glutath
293 chemical mechanisms of peroxide reduction by low molecular weight thiols, Prxs, GPxs, and other thiol
296 ry clearance.Methods: The effects of a novel low-molecular-weight TMEM16A potentiator (ETX001) were e
298 ng of free PAI-1 and complexes of PAI-1 with low-molecular-weight urokinase-type plasminogen activato
299 mers (-9+/-1%, P<0.0001) and accumulation of low-molecular-weight vWF multimers (+40+/-5%, P<0.0001)