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1 esis, and inhibits cholesterol uptake by the low-density lipoprotein receptor.
2 e expression for lipoprotein lipase and very-low-density lipoprotein receptor.
3 t mice (0.162 cm(2)+/-0.023 [n=9], P2X7(-/-) low density lipoprotein receptor(-/-) : 0.084 cm(2)+/-0.
4 tack complex domain (FIMAC), CD5 domain, and low density lipoprotein receptor 1 (LDLr1) and LDLr2 dom
5 transforming growth factor beta 1, oxidized low-density lipoprotein receptor 1, and C-C motif chemok
13 Reversa mice, which are deficient in the low-density lipoprotein receptor and in which hyperchole
14 lesterol lowering, with the discovery of the low-density lipoprotein receptor and its physiology and
15 PCSK9, which promotes the degradation of low-density lipoprotein receptors and, therefore, the in
16 role for both a t-PA receptor, most likely a low-density lipoprotein receptor, and a plasminogen rece
17 n that the longer Sepp1 isoforms bind to the low density lipoprotein receptor apoER2, but the mechani
19 screen identified cholesterol uptake by the low-density lipoprotein receptor as essential for the gr
20 che within macrophage by modulating oxidized low-density lipoprotein receptor CD36, phagolysosomal ma
21 atp-binding cassette transporter (atp), and low-density lipoprotein receptor chaperone (ldlr), that
22 forms showed that the amino-terminal modular low-density lipoprotein receptor class A (LA) domains wi
23 e-wide CRISPR-Cas9-based screen, we identify low-density lipoprotein receptor class A domain-containi
24 ucing liver-specific degradation of the LDL (low-density lipoprotein) receptor combined with a 10-wee
25 thylglutaryl-coenzyme A reductase, and human low-density lipoprotein receptor), compared to uninfecte
27 the inflamed aorta in atherosclerosis-prone low-density lipoprotein receptor deficient (Ldlr(-/-)) m
28 bred onto both the Apoe(-/-) and Ldlr(-/-) (low-density lipoprotein receptor deficient) knockout str
30 arrow-restricted deletion of DNGR-1 in Ldlr (low-density lipoprotein receptor)-deficient mice (Ldlr(-
31 y of Nur77 on atherosclerosis was studied in low density lipoprotein receptor-deficient (Ldlr(-/-)) m
32 rom male Flna (o/fl)/ LC mice to atherogenic low-density lipoprotein receptor-deficient ( Ldlr(-/-))
34 tic lesions and spleens of high-fat diet-fed low-density lipoprotein receptor-deficient (Ldlr(-/-)) m
35 herosclerotic lesions from high-fat diet-fed low-density lipoprotein receptor-deficient (Ldlr(-/-)) m
36 Lethally irradiated, atherosclerosis-prone, low-density lipoprotein receptor-deficient (Ldlr(-/-)) m
38 Tet2-mutant cells in atherosclerosis-prone, low-density lipoprotein receptor-deficient (Ldlr(-/-)) m
39 ate senescent cells in atherosclerosis-prone low-density lipoprotein receptor-deficient (Ldlr(-/-)) m
40 od vessels invading photoreceptors: the very low-density lipoprotein receptor-deficient (Vldlr(-/-) )
46 the liver of diet-induced insulin-resistant low-density lipoprotein receptor-deficient mice and of g
47 lammation and reduced steatosis in livers of low-density lipoprotein receptor-deficient mice fed a We
48 results in decreased hepatic inflammation in low-density lipoprotein receptor-deficient mice on a Wes
49 ress as prime response pathways in livers of low-density lipoprotein receptor-deficient mice on a Wes
53 ux in atherosclerosis-susceptible Ldlr(-/-) (low-density lipoprotein receptor-deficient) mice is subs
54 erosclerosis and insulin resistance in mice, low-density lipoprotein receptor-deficient, S100A9-defic
56 subtilisin/kexin type 9 (PCSK9) binds to the low-density lipoprotein receptor, escorting it to its de
57 s a result of lower hepatic mRNA editing and low-density lipoprotein receptor expression, and higher
59 -related protein 1 (LRP1) is a member of the low density lipoprotein receptor family and plays import
60 olecular chaperone that binds LRP1 and other low density lipoprotein receptor family members in the e
61 oprotein receptor (VLDLR) is a member of the low-density lipoprotein receptor family that binds multi
62 -2) is a protein structurally related to the low-density lipoprotein receptor family that displays a
64 levels by raising the expression of SREBP2, low-density lipoprotein receptor, HMGCo-A reductase, and
65 nvertase subtilisin kexin 9 (PCSK9) binds to low-density lipoprotein receptors, increasing serum LDL-
66 the in vivo models of C57BL/6 wild-type and low density lipoprotein receptor knock-out (LDLR(-/-)) m
67 when Foxo1(KR/KR) mice are intercrossed with low density lipoprotein receptor knock-out mice (Ldlr(-/
68 of G5-PEG and PB-NLCs were investigated in a low density lipoprotein receptor knockout (LDLr-/-) mous
69 vels by 22 and 31%, respectively, in fasting low-density lipoprotein receptor knockout (LDLR(-/-)) mi
72 in ovalbumin- (OVA-) sensitized C57BL/6 and low-density lipoprotein receptor knockout mice (LDLr(-/-
73 of atherogenesis by mPGES-1 deletion in the low-density lipoprotein receptor knockout mice (n=17-21)
76 and vascular leakage in the eyecups of very low-density lipoprotein receptor knockout mice, a model
80 moxifen exerts an atheroprotective action on low density lipoprotein receptor (LDL-r(-/-)) female mic
82 K9) down-regulates surface expression of the low-density lipoprotein receptor (LDL-R), increasing ser
83 ls was transplanted into lethally irradiated low density lipoprotein receptor Ldlr(-/-) mice on an at
84 a1(-/-) mice to mice that do not express the low density lipoprotein receptor (Ldlr(-/-)), which are
85 epidermal growth factor-like-A domain of the low density lipoprotein receptor (LDLR) and mediates LDL
86 ted sdAbs efficiently blocked PCSK9-mediated low density lipoprotein receptor (LDLR) degradation in c
87 bind heparin and receptors belonging to the low density lipoprotein receptor (LDLR) family, known to
92 Mice fed a Western-type diet and lacking low-density lipoprotein receptor (Ldlr(-/-)T39(-/-)) sho
93 because of loss-of-function mutations in the low-density lipoprotein receptor (LDLR) and homozygous f
95 a dramatic reduction in transcript levels of low-density lipoprotein receptor (LDLR) and of keratin g
96 The effect of the treatments on cellular low-density lipoprotein receptor (LDLR) and proprotein c
97 fied sulfated glycosaminoglycans (sGAGs) and low-density lipoprotein receptor (LDLR) as host factors
98 in genetically deficient iPSC utilizing the low-density lipoprotein receptor (LDLR) deficiency Famil
101 PSCs from JD a patient with mutations in the low-density lipoprotein receptor (LDLR) gene that result
102 le nucleotide polymorphism in exon 12 of the low-density lipoprotein receptor (LDLR) gene, rs688, has
103 which cystathionine beta-synthase (CBS) and low-density lipoprotein receptor (LDLr) genes were defic
104 of cholesterol and an overexpression of the low-density lipoprotein receptor (LDLR) in pancreatic tu
111 ime in atherosclerotic lesion macrophages of low-density lipoprotein receptor (Ldlr) knockout mice fe
112 e crossed Gsk3a/GSK3alpha-knockout mice with low-density lipoprotein receptor (Ldlr) knockout mice.
113 r risk for patients who already have reduced low-density lipoprotein receptor (LDLR) levels, such as
116 btilisin/kexin type 9 (PCSK9), which reduces low-density lipoprotein receptor (LDLR) recycling and he
119 at administering NAPE-expressing bacteria to low-density lipoprotein receptor (Ldlr)(-/-) mice fed a
120 we demonstrate that modulating levels of the low-density lipoprotein receptor (LDLR), a cell surface
121 2 (Dab2) recruits its cargoes, including the low-density lipoprotein receptor (LDLR), and mediates en
123 at for one of the identified substrates, the low-density lipoprotein receptor (LDLR), ERdj5 is requir
124 audin-1 (CLDN1), Occludin (OCLN), SR-BI, and low-density lipoprotein receptor (LDLR), function mainly
125 tercellular adhesion molecule-1 (ICAM-1) and low-density lipoprotein receptor (LDLR), inter- and intr
126 s, we identified 2 nonsynonymous variants in low-density lipoprotein receptor (LDLR), namely p.G116S
127 ceptor/coreceptor molecules CD81, claudin-1, low-density lipoprotein receptor (LDLr), occludin, and S
128 ertase subtilisin/kexin type 9 (PCSK9) binds low-density lipoprotein receptor (LDLR), preventing its
129 sponsible for the degradation of the hepatic low-density lipoprotein receptor (LDLR), which in turn r
131 mice, apolipoprotein E (apoE)-deficient and low-density lipoprotein receptor (LDLR)-deficient mice t
133 receptor tyrosine-protein kinase), and Lrp4 (low-density lipoprotein receptor (LDLR)-related protein
134 We previously demonstrated that macrophage low-density lipoprotein receptor (LDLR)-related protein
138 n (MYLIP, aka IDOL and inducible degrader of low-density lipoprotein receptor [LDLR]), with LDL chole
140 els through a mechanism that is dependent on low-density lipoprotein receptors (LDLRs) and LDLR-relat
142 eased plasma PCSK9 levels, increased hepatic low-density lipoprotein receptor levels, and decreased p
144 xpression was analyzed in aortic arches from low density lipoprotein receptor(-/-) mice consuming a h
146 were transplanted into irradiated recipient low-density lipoprotein receptor(-/-) mice, and atherosc
148 in apolipoprotein-deficient (apoE(-/-)) and low-density lipoprotein receptor negative (LDLR(-/-)) mi
151 clerotic lesion size was found in Ldlr(-/-) (low-density lipoprotein receptor null) mice transplanted
152 hages worsened atherosclerosis in irradiated low-density lipoprotein receptor null-recipient mice and
154 en by a SM22Cre-IKKbeta-flox system rendered low density lipoprotein receptor-null mice resistant to
155 eficiency on experimental atherosclerosis in low-density lipoprotein receptor-null mice (Ldlr(-/-)).
156 n the vascular smooth muscle lineage of male low-density lipoprotein receptor-null mice, a background
157 APP chimeras harboring targeting motifs from low-density lipoprotein receptor or neuron-glia cell-adh
158 ncrease in permeability, whereas blockade of low-density lipoprotein receptors or exposed lysine resi
159 d via the liver provided that an intact apoE-low-density lipoprotein receptor pathway is present.
161 se subtilisin/kexin type 9 (PCSK9) regulates low density lipoprotein receptor protein levels by diver
163 L mice showed dramatic reductions in hepatic low-density lipoprotein receptor protein and increased p
165 ntibodies developed in these mice, LDLR(-/-)/low-density lipoprotein receptor Rag 1 double-knockout m
167 IDOL pathway in the liver can override other low-density lipoprotein receptor regulatory pathways lea
168 endent internalization of Abeta bound to the low density lipoprotein receptor related protein-1, a ke
169 complex formation involves Frizzled4 (Fz4), low-density lipoprotein receptor related protein 5/6 (Lr
170 ckkopf2 (Dkk1/2), to their cognate receptor, low-density-lipoprotein-receptor related protein 6 (LRP6
173 htly to the clearance and signaling receptor low density lipoprotein receptor-related protein 1 (LRP1
176 und that ADAMTS-5 is rapidly endocytosed via low density lipoprotein receptor-related protein 1 (LRP1
178 ndocytic clearance by the scavenger receptor low density lipoprotein receptor-related protein 1 (LRP1
179 ent increases mRNA and protein expression of low density lipoprotein receptor-related protein 2 and a
180 served amino acid position (p.R1188W) in the low density lipoprotein receptor-related protein 5 (LRP5
181 morphogenesis gene 2, as well as coreceptor low density lipoprotein receptor-related protein 6 (LRP6
182 ay genes, such as frizzled homolog 7 (FZD7), low density lipoprotein receptor-related protein 6 and t
183 hosphorylation of eNOS was decreased by anti-low density lipoprotein receptor-related protein-1 (LRP)
184 es, and we found that the endocytic receptor low density lipoprotein receptor-related protein-1 (LRP-
186 oligomers was dependent on the transmembrane low density lipoprotein receptor-related protein-1 (LRP1
188 ent and activation of beta1 integrin via the low density lipoprotein receptor-related protein-1 (LRP1
190 bind to two distinct receptors, namely, the low-density lipoprotein receptor-related protein (LRP) a
192 We previously reported that RanBP9 binds low-density lipoprotein receptor-related protein (LRP),
193 ng phospholipids, von Willebrand factor, and low-density lipoprotein receptor-related protein (LRP).
194 e largest member of the LDL receptor family, low-density lipoprotein receptor-related protein (LRP1).
196 We found that an extracellular fragment of low-density lipoprotein receptor-related protein 1 (LRP-
198 tween BKCaand both alpha2M and its receptor, low-density lipoprotein receptor-related protein 1 (LRP1
199 pericytes also requires the function of the low-density lipoprotein receptor-related protein 1 (LRP1
201 llaries was associated with its reduction in low-density lipoprotein receptor-related protein 1 (LRP1
202 t portion of apoE and sAbeta compete for the low-density lipoprotein receptor-related protein 1 (LRP1
204 e has demonstrated significant roles for the low-density lipoprotein receptor-related protein 1 (LRP1
206 ction with the endocytic scavenger receptor, low-density lipoprotein receptor-related protein 1 (LRP1
207 g internalization of a SNX17 cargo receptor, low-density lipoprotein receptor-related protein 1 (LRP1
209 , the receptors for these secreted proteins, low-density lipoprotein receptor-related protein 1 (LRP1
211 s isoform-specific interactions of apoE with low-density lipoprotein receptor-related protein 1 on br
213 ASA-ApoE-II, uptake was partially due to the low-density lipoprotein receptor-related protein 1.
214 se in the brain was impaired in mice lacking low-density lipoprotein receptor-related protein 4 (Lrp4
216 jects have identified autoantibodies against low-density lipoprotein receptor-related protein 4 (LRP4
217 tenance of neuromuscular synapses, and (iii) low-density lipoprotein receptor-related protein 4 (Lrp4
218 inding of y+z+ agrin to both heparin and the low-density lipoprotein receptor-related protein 4 (LRP4
220 s anti-osteoanabolic activity is enhanced by low-density lipoprotein receptor-related protein 4 (Lrp4
222 ctin, a protein acting downstream from agrin/low-density lipoprotein receptor-related protein 4 (LRP4
223 We identified previously in vitro LRP4 (low-density lipoprotein receptor-related protein 4) as a
224 -derived protein, which interacts with LRP4 (low-density lipoprotein receptor-related protein 4) to a
225 ancer have identified novel functions of the low-density lipoprotein receptor-related protein 4-muscl
226 spectroscopy and show that the co-receptor, low-density lipoprotein receptor-related protein 5 (Lrp5
227 Wnt signaling ligand or receptors, including low-density lipoprotein receptor-related protein 5 (LRP5
228 e human skeleton is affected by mutations in low-density lipoprotein receptor-related protein 5 (LRP5
229 ated the conditional knockout Wnt coreceptor low-density lipoprotein receptor-related protein 5 (Lrp5
230 ptions of tryptophan hydroxylase 1 (Tph1) or low-density lipoprotein receptor-related protein 5 (Lrp5
231 in Lrp5(ACT) mice in which a mutation in the low-density lipoprotein receptor-related protein 5 Wnt c
232 nt signaling, we observed elevated levels of low-density lipoprotein receptor-related protein 5/6 (LR
233 riched around the Wnt-activated Frizzled and low-density lipoprotein receptor-related protein 5/6 rec
234 to determine contributions of Wnt coreceptor low-density lipoprotein receptor-related protein 6 (LRP6
238 a critical chaperone for the Wnt coreceptor low-density lipoprotein receptor-related protein 6 (LRP6
240 ation, where it binds to the Wnt co-receptor low-density lipoprotein receptor-related protein 6 (LRP6
241 quires caveolin-dependent internalization of low-density lipoprotein receptor-related protein 6 (LRP6
242 nin signaling pathway by down-regulating the low-density lipoprotein receptor-related protein 6 (LRP6
243 ical Wnt ligand Wnt3a and the Wnt coreceptor low-density lipoprotein receptor-related protein 6 (LRP6
244 rotein receptor-related protein 5 (Lrp5) and low-density lipoprotein receptor-related protein 6 (Lrp6
245 s duplication in Xenopus embryos, stimulated low-density lipoprotein receptor-related protein 6 (LRP6
247 t signaling by binding to the Wnt coreceptor low-density lipoprotein receptor-related protein 6 (LRP6
249 ecific for the E1E2 domain of Wnt coreceptor low-density lipoprotein receptor-related protein 6, Mab2
251 itatory synapse number were mediated via the low-density lipoprotein receptor-related protein and sub
252 se domain 9 (ADAM9), reticulon 4 (RTN4), and low-density lipoprotein receptor-related protein associa
254 sense substitutions within LRP1B, encoding a low-density lipoprotein receptor-related protein tied to
255 have been reported to be endocytosed by the low-density lipoprotein receptor-related protein-1 (LRP-
256 the neurovascular hypothesis, impairment of low-density lipoprotein receptor-related protein-1 (LRP1
259 e N-methyl-d-aspartate receptor (NMDA-R) and low-density lipoprotein receptor-related protein-1 (LRP1
260 ple receptors including mannose receptor and low-density lipoprotein receptor-related protein-1 (LRP1
262 (LPS) by a pathway that apparently requires low-density lipoprotein receptor-related protein-1 (LRP1
263 rocytic thrombospondin-1 (TSP1) and synaptic low-density lipoprotein receptor-related protein-1 (LRP1
264 rocytic thrombospondin-1 (TSP1) and synaptic low-density lipoprotein receptor-related protein-1 (LRP1
267 alytic hemopexin domain of MMP9 binds to the low-density lipoprotein receptor-related protein-1, trig
268 sis and lysosome-dependent degradation in an low-density lipoprotein receptor-related protein-1-depen
269 -dependent PDGFRbeta protein degradation via low-density lipoprotein receptor-related protein-1.
270 n neutrophils and monocytes to MDSCs via the low-density lipoprotein receptor-related protein-2 (LRP2
271 metabolism and insulin sensitivity through a low-density lipoprotein receptor-related protein-2 (LRP2
272 y, we show that Wnt receptors (Frizzled4 and low-density lipoprotein receptor-related protein5 [Lrp5]
273 n (RAP), a ligand-binding antagonist for the low-density lipoprotein receptor-related proteins (LRPs)
274 1 (DKK-1), a ligand for the WNT coreceptors low-density lipoprotein receptor-related proteins 5 and
275 receptors frizzled 1-10 and the co-receptors low-density lipoprotein receptor-related proteins 5 and
276 e frizzled receptor (FZD) and the coreceptor low-density lipoprotein-receptor-related protein 5 (LRP5
277 loci, rs1466535, located within intron 1 of low-density-lipoprotein receptor-related protein 1 (LRP1
279 Here we show that the soluble form of the low-density lipoprotein receptor relative, LR11/SorLA (s
280 via apolipoprotein E receptor 2 and the very low density lipoprotein receptor, resulting in the phosp
281 Drosophila vitellogenin receptor Yolkless, a low density lipoprotein receptor superfamily member, occ
282 teraction with the RELN receptor VLDLR (very low-density lipoprotein receptor); this was confirmed by
283 These antibodies prevent the degradation of low density lipoprotein receptor, thus lowering serum le
284 thereby preventing the recirculation of the low-density lipoprotein receptor to the hepatocyte cell
285 ch region (aa 95-141) that separates the two low-density lipoprotein receptor type A (LDLR-A) domains
287 n signals via the lipoprotein receptors very low density lipoprotein receptor (VLDLR) and apolipoprot
288 polipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR) and is internal
289 We discovered that miR-200c targets the very low density lipoprotein receptor (Vldlr) and its ligand
293 ed choroidal neovascularization and the very low density lipoprotein receptor (Vldlr)-knockout mouse]
296 thways including through the receptors, Very low-density lipoprotein receptor (Vldlr), Apolipoprotein
297 e deficient in another Reelin receptor, very low-density lipoprotein receptor (VLDLR), had normal rod
299 nopathy and another angiogenic model of very-low-density lipoprotein receptor (Vldlr)-deficient (Vldl
300 ion disrupts an interaction with VLDLR (very low-density lipoprotein receptor), while the APOER2 sign