ライフサイエンスコーパス: lumenal

1 onstrate that elevating levels of intestinal lumenal 5-HT by oral supplementation or genetic deficien

2 nant negative towards transcytosis, inhibits lumenal accumulation.

3 tential means for misfolded extracellular or lumenal alpha-syn to access cytosolic alpha-syn.

4 somes are specialized platforms for both the lumenal and cytosolic sensing of pathogens.

5 establishes a functional connection between lumenal and membrane events driving this process.

6 ic-diet study, we compare microbial loads in lumenal and mucosal samples along the GI tract.

7 macaques by 16S sequencing feces and paired lumenal and mucosal samples from ten sites distal to the

8 -length A34 or a construct consisting of the lumenal and transmembrane domains restored normal traffi

9 smic reticulum (ER) transmembrane protein is lumenal and which one is facing the cytosol.

10 r intrinsic immune response in comparison to lumenal apical infections.

11 septate junction formation, deposition of a lumenal/apical extracellular matrix, and lumenal secreti

12 is also frequently assayed by the mixing of lumenal aqueous compartments, using probes of low molecu

13 (LPS), (2) cluster on the surface of native lumenal bacteria, (3) prevent the adherence of enteropat

14 unit contains 11 transmembrane helices and a lumenal beta-trefoil fold termed the MIR domain.

15 d are associated with increased levels of ER Lumenal Binding Protein (BiP).

16 Depletion of either one of the ER lumenal BiP co-chaperones, ERj3 and ERj6, but not the ER

17 Lumenal bovine serum albumin (BSA) lowered the lumenal i

18 NPC, potentially through the formation of a lumenal bridge with Pom152p.

19 R gating through calsequestrin (CSQ), the SR lumenal Ca(2+) buffer.

20 luor to the endolysosomal pathway, we mapped lumenal Ca(2+) changes during endosomal maturation and f

21 It is extremely challenging to quantitate lumenal Ca(2+) in acidic Ca(2+) stores of the cell becau

22 steady-state P(o) effectively increase as SR lumenal Ca(2+) increases.

23 However, recent experiments suggest that SR lumenal Ca(2+) may also participate in regulating RyR ga

24 ng endosomal maturation and found a surge in lumenal Ca(2+) specifically in lysosomes.

25 simulation under controlled cytosolic and SR lumenal Ca(2+).

26 to the identification of key residues on the lumenal capsid surface that are important for AAP-VP and

27 expand (or reseal), slowing the dispersal of lumenal cargo proteins and granule membrane proteins.

28 rom fusion sites and promotes the release of lumenal cargo proteins.

29 le cells are trafficked to generate a common lumenal cavity.

30 In human lumenal cells, activation of TP53 by inhibiting MDM2 or

31 ired for specification of the basal, but not lumenal cells.

32 served membrane-intrinsic helix hairpin, the lumenal channel protonates an acidic glutamate in the c-

33 on, a ratcheting mechanism is used by the ER-lumenal chaperone BiP in eukaryotes, and a pushing mecha

34 lly we show that a conserved cysteine in the lumenal chaperone BiP is susceptible to oxidation by per

35 ERp44 is an ER lumenal chaperone protein that favors the maturation of

36 78/BiP, a typical endoplasmic reticulum (ER) lumenal chaperone, can be expressed on the cell surface,

37 ion has been described, massive reduction of lumenal chloride is observed that is 10(3) fold greater

38 Lumenal collapse occurs because the acinus is unstable t

39 This mucosal and lumenal community variability corresponded to functional

40 ittle fusion with the more rigorous assay of lumenal compartment mixing.

41 g proteoliposomes was required for efficient lumenal compartment mixing.

42 pressed proteins into either the membrane or lumenal compartment of OMVs.

43 The entry of the analogue into the lumenal compartment was confirmed by demonstrating that

44 remained inaccessible to both cytosolic and lumenal compartments until translation was terminated.

45 ssment of lipid mixing, the mixing of intact lumenal compartments, any lysis that occurs, and the mem

46 water channel are delivered to cytosolic and lumenal compartments.

47 permeability may facilitate the movement of lumenal contents across the mucosa, thus helping to expl

48 y granule membrane with the plasma membrane, lumenal contents are rapidly discharged and dispersed in

49 ther Crumbs or phosphomimetic Moesin induced lumenal cysts and decreased terminal branching.

50 T cell receptor (TCR) as a model to analyze lumenal determinants of ER quality control with a partic

51 ed in tracheal fusion cell morphogenesis and lumenal development.

52 CystC-deficiency increased lumenal diameter and lesion size compared with control m

53 Lumenal diameters of the remaining capillaries in wet AM

54 ERdj3 was identified as a soluble, lumenal DnaJ family member that binds to unassembled imm

55 We found that the core ER-lumenal domain (cLD) of yeast Ire1 binds to unfolded pro

56 that similar to yeast, human IRE1alpha's ER-lumenal domain (hIRE1alpha LD) binds peptides with a cha

57 Interaction of NPC2 with NPC1 lumenal domain 2 is only detected at acidic pH, conditio

58 For these experiments, a soluble NPC1 lumenal domain 2 was engineered by replacing adjacent tr

59 The E3-19K lumenal domain activates the IRE1alpha nuclease, which i

60 cific physical interaction between the Heh1p lumenal domain and the massive cadherin-like lumenal dom

61 ing a stable IRE1 fragment comprising the ER-lumenal domain and transmembrane segment (LDTM).

62 ted mutant of bZIP28 eliminating most of the lumenal domain does not bind BiP and is not retained in

63 Unfolded ER proteins cause IRE1alpha lumenal domain homo-oligomerization, inducing trans auto

64 IRAP without the lumenal domain is faithfully targeted to the donor membr

65 we report that oligomeric assembly of the ER-lumenal domain is sufficient to drive Ire1 clustering.

66 r, lamina associated polypeptide 1 (LAP1) or lumenal domain like LAP1 (LULL1), to form an ATPase; the

67 h lamina-associated polypeptide 1 (LAP1) and lumenal domain like LAP1 (LULL1).

68 he companion to this paper, we show that the lumenal domain of A33 is sufficient for interaction with

69 In contrast, the lumenal domain of A33 is sufficient for interaction with

70 Furthermore, the lumenal domain of A33 is sufficient to restore the prope

71 panel of charge-to-alanine mutations in the lumenal domain of A33 to map the B5 interaction site.

72 Thbs bind the ER lumenal domain of activating transcription factor 6alpha

73 ot necessarily its own, is requisite for the lumenal domain of B5 to interact with A33.

74 d system and chemical cross-linking that the lumenal domain of IRAP can interact with the lumenal loo

75 The ER lumenal domain of MKS3 interacted with a complex that in

76 chromatography, we show here that the second lumenal domain of NPC1 binds directly to NPC2 protein.

77 l prop to position other determinants in the lumenal domain of p75 for oligomerization.

78 Here we show that the lumenal domain of recombinant Cosmc directly interacts s

79 lumenal domain and the massive cadherin-like lumenal domain of the membrane nucleoporin Pom152p.

80 ity by direct binding to cysteine 148 in the lumenal domain of the sensor, which is oxidized when IRE

81 mic reticulum membrane, comprising a sensory lumenal domain, and tandem kinase and endoribonuclease (

82 ytosolic Hsc70-binding J domain, but not the lumenal domain, is essential for its targeting to the fo

83 or Sel1L directly through Sel1L's N-terminal lumenal domain, thereby linking ERdj5 to the Hrd1 comple

84 n-insertase EMC function mediated by the EMC lumenal domain.

85 ransmembrane helices, and a large C-terminal lumenal domain.

86 ion involves a coiled-coil domain within the lumenal domain.

87 d occurred even in the absence of its native lumenal domain.

88 nsmembrane segments (TMs) and three distinct lumenal domains A (also designated NTD), C, and I.

89 that the two proteins interact through their lumenal domains and that the coiled-coil domain of B5 is

90 ne insertion of TMDs, explain why only short lumenal domains are translocated by EMC, and constrain m

91 Binding of torsinA to their C-terminal lumenal domains is stabilized when residues in any one o

92 n together, our results demonstrate that the lumenal domains of A33 and B5 interact and that the inte

93 erved between NBD1 and other cytoplasmic and lumenal domains of ABCA4.

94 t of GSVs, and we show it interacts with the lumenal domains of GLUT4 and other GSV constituents.

95 roteins, and membrane proteins with adhesive lumenal domains that may have contributed to the evoluti

96 in has 13 transmembrane domains, three large lumenal domains, and a cytoplasmic tail.

97 of 13 transmembrane helices (TMs) and three lumenal domains, exports low-density-lipoprotein (LDL)-d

98 ent on the synergy of both nucleoplasmic and lumenal domains.

99 The lumenal EF-hand and SAM domains of STIM1 are believed to

100 till be monitored conventionally in the FAVE lumenal effluent.

101 g that Val49 fits into a constriction at the lumenal end of the M2 helix of SERCA, possibly controlli

102 lar sinus endothelium as opposed to the vein lumenal endothelium, and the opposite pattern with VWF (

103 nd helical segments close to the stromal and lumenal ends.

104 uberant immune system and a highly antigenic lumenal environment, the intestinal epithelium must rema

105 ntify other proteins including the monotopic lumenal enzyme cyclooxygenase 1 (prostaglandin H synthas

106 obasally polarized cysts, reminiscent of the lumenal epiblast stage, providing a model to explore key

107 of apico-basal polarity is critical for the lumenal epiblast-like morphogenesis of human pluripotent

108 at allows them to self-organize and form the lumenal epiblast-like stage.

109 orphogenesis and defects in the clearance of lumenal epithelial cells.

110 reductase by determining susceptibility of a lumenal epitope in the enzyme to in vitro protease diges

111 Susceptibility of the lumenal epitope to protease digestion and thus membrane

112 Lumenal ER calcium depletion caused rapid oligomerizatio

113 Remarkably, the lumenal ER chaperone GRP94 was hyperglycosylated in STT3

114 ontrol of membrane proteins and connects the lumenal ER chaperone machinery to membrane protein bioge

115 merous misfolded proteins including soluble, lumenal ERAD-L and membrane-anchored ERAD-M substrates.

116 R)-associated degradation (ERAD) of numerous lumenal (ERAD-L) and membrane-anchored (ERAD-M) substrat

117 ER membrane translocation and connect these lumenal events with events on the ER membrane.

118 toxin treatment of HIEs caused physiological lumenal expansion detected by time-lapse microscopy, rec

119 Arteriogenesis, or the lumenal expansion of pre-existing arterioles in the pres

120 roducing single disulfide bonds to constrain lumenal/extracellular domains or shortening a cytoplasmi

121 The other lumenal extrinsic proteins (PsbO, PsbU, PsbV, and PsbQ)

122 ed in the context of recruitment of the PSII lumenal extrinsic proteins and Mn4CaO5 cluster assembly.

123 has been proposed that the Psb27 protein, a lumenal extrinsic subunit, serves as a PSII assembly fac

124 nds must extend for at least 20 A across the lumenal face of the Mn(4)Ca cluster.

125 Prior to ER membrane penetration, ER lumenal factors impart structural rearrangements to the

126 RAD substrate was encapsulated with selected lumenal factors inside mammalian microsomes.

127 Our study thus pinpoints two ER lumenal factors that coordinately prime SV40 for ER memb

128 In this report, we identify two ER lumenal factors that prepare the virus for ER membrane t

129 f the jacket and permeates in, rendering the lumenal flow strongly acidic (pH </= 2) that suppresses

130 led reversed net water secretion and reduced lumenal flux of different molecular probes (bovine serum

131 al differential equations for myoplasmic and lumenal free Ca(2+) and Ca(2+)-binding molecules in the

132 the stromal gap, steric repulsion across the lumenal gap, and regulation of protein density by exchan

133 terminal domain, the intramembrane hole, the lumenal gate, the lumen of LptD channel, and the extrace

134 -pHluorin (SpH), a synaptic vesicle-targeted lumenal GFP (green fluorescent protein), whose fluoresce

135 kar2 mutant was defective for transfer of NE lumenal GFP, but not diffusion within the lumen, suggest

136 phate linkage with recovery of its lipid and lumenal glycan components.

137 (Gal9) or loss of its capacity to recognize lumenal glycans exposed during lysosomal membrane damage

138 mbination of intracellular and extracellular/lumenal glycoproteins.

139 s to the degradation of a mutant lacking the lumenal glycosylation domain (DeltaGly).

140 We show here that a soluble, lumenal Golgi resident protein, Cab45, is required for S

141 ression of an ER-adapted catalase to degrade lumenal H2O2 attenuated PRDX4-mediated disulfide bond fo

142 the cytoplasmic half of TM7 and TM8 and the lumenal half of TM3, TM4, and TM7.

143 unit a and the proteolipid ring, whereas the lumenal hemichannel is located within subunit a at the i

144 tent with this hypothesis, yeast lacking the lumenal Hsp40s, Jem1 and Scj1, exhibited defects in ENaC

145 We discovered that the ER lumenal Hsp70, BiP, an associated Hsp40, Scj1, and a nuc

146 ic reticulum (ER), it interacted with the ER-lumenal Hsp70, BiP, and bound to BiP substrates.

147 uestion, we introduced mutations into the ER-lumenal Hsp70, BiP/Kar2p, and found that an R217A substi

148 with physiological concentrations of the ER lumenal Hsp70-type chaperone BiP encourages disassembly.

149 C5(-/-) mice displayed significantly reduced lumenal inflammatory infiltration and cytokine productio

150 Previous work has suggested that the lumenal interaction between Glut4 and sortilin and the c

151 We suggest that lumenal interactions between Glut4 and IRAP play an impo

152 menal bovine serum albumin (BSA) lowered the lumenal ionic strength at which ProP became active.

153 The attainable range of lumenal ionic strength was expanded by lowering the phos

154 d proteins, several thylakoid proteases, and lumenal isomerases did not change, while PsbS increased

155 Conversely, when a mammalian ER-lumenal JDP, ERdj3, was directed to the yeast cytosol, i

156 nd nuclei, more persistent basal and ectopic lumenal KRT14(+) cells, and signs of metaplasia (attenua

157 For each power stroke, a lumenal lever from a single subunit is electrostatically

158 Thus physical properties of the lumenal ligand-receptor complex appear to act as key det

159 ological reporters in bacteria, we deduced a lumenal location for the redox active domains of the pro

160 te opening, mutations were introduced into a lumenal loop (L7) that connects TM7 and TM8.

161 inear sequences of the endoplasmic reticulum-lumenal loop (Ser52-Phe55) and the first (Leu22-Lys30) a

162 P activity involves binding of BiP to the ER lumenal loop 7 of Sec61alpha in the vicinity of tyrosine

163 assembly into the STT3A complex, whereas the lumenal loop and the N-terminal cytoplasmic segment are

164 ter two functions are thought to involve the lumenal loop and the N-terminal domain.

165 CP43, possibly in the vicinity of the large lumenal loop connecting transmembrane helices 5 and 6 of

166 the psaD-->C-->A-->B organization contains a lumenal loop conserved in PsaA proteins from Synechococc

167 TM3 and the adjoining lumenal loop contribute residues important for Dnf1 PC p

168 The conformation of the lumenal loop domain is surprisingly different between LH

169 However, distances comprising the lumenal loop domain show broader distance distributions,

170 olved in current crystal structures, and the lumenal loop domain.

171 lumenal domain of IRAP can interact with the lumenal loop of Glut4.

172 We showed that lumenal lysosomal chloride, which is implicated in vario

173 ed that ProP is an ionic strength sensor and lumenal macromolecules activate ProP by altering ion act

174 , and overexpression of ERdj3 and ERdj4, two lumenal mammalian Hsp40s, increased the proteasome-media

175 and, in contrast to them, do not contain ER-lumenal markers possessing a C-terminal HDEL sequence.

176 sis produces similar results for most of the lumenal markers, the transmembrane marker phogrin-FP sho

177 or the dynamic organization of the transient lumenal matrix and normal structure of the cuticle that

178 Clearance of lumenal matrix and subcellular localization of clathrin

179 -1 adaptor in apical polarity during de novo lumenal membrane biogenesis in the C. elegans intestine.

180 The localization of His-379 on the lumenal membrane surface is consistent with a role for t

181 on transfer protein plastocyanin (Pc) to the lumenal membrane surface of the cytb6f complex using a P

182 On the lumenal membrane surface, subunit f establishes direct c

183 fts and is selectively incorporated into the lumenal membranes of the endosomes to escape the endosom

184 alterations in gut microbial abundances and lumenal metabolite concentrations, but the effects of sp

185 t loses its capacity to prevent adherence of lumenal microbes.

186 onstrates that increased recombination among lumenal microbial populations is a phenotype associated

187 mposition of mucosa-associated compared with lumenal microbiota in pig caecum.

188 e.g., Helicobacter and Treponema), while the lumenal microbiota showed inter-individual variation and

189 s these populations a higher potential, than lumenal microbiota, in exerting effects on the host.

190 Using real-time analyses of lumenal microenvironmental parameters, in conjunction wi

191 here-designated UPR-L, is induced by the ER lumenal misfolded protein, CPY*.

192 leak channel in HeLa cells and identified ER lumenal molecular chaperone immunoglobulin heavy-chain-b

193 pyrophosphate (Dol-P-P) is discharged in the lumenal monolayer of the endoplasmic reticulum (ER).

194 ylatable peptide, to generate Dol-P-P in the lumenal monolayer produced corresponding increases in th

195 traverse the membrane, defining torsinA as a lumenal monotopic membrane protein and requiring a new p

196 hes in ER sheets, as might be expected for a lumenal monotopic membrane protein.

197 -) tracheas exhibited significant, neonatal, lumenal mucus accumulation.

198 cargo proteins and lead to the formation of lumenal MVB vesicles that are predominantly small compar

199 epends on terminal processing of a subset of lumenal N-glycans.

200 Morphometric measurement demonstrated lumenal narrowing from inwards collapse of hyalinized ar

201 plex plexiform-like lesions characterized by lumenal obliteration, intimal disruption, medial hypertr

202 Lumenal obstruction has typically been regarded as the c

203 acetylcholine to the airway constrictive and lumenal obstructive response after inhalation injury and

204 nascent chain exposure between cytosolic and lumenal occur without compromising the permeability barr

205 The mutations clustered around the lumenal opening of the transporter and mapped to either

206 sfer of a subset of membrane lipids from the lumenal or exofacial leaflet to the cytofacial aspect of

207 PEG-mal in the absence of SDS, suggesting a lumenal orientation.

208 ER lumenal p58(IPK) could be coimmunoprecipitated with a ne

209 Owing to its lumenal pH (approximately 5) and fusion with endolysosom

210 By ratiometrically reporting lumenal pH and Ca(2+) simultaneously, CalipHluor functio

211 The lumenal pH of an organelle is one of its defining charac

212 Many lysosome functions are determined by a lumenal pH of ~5.0, including the activity of resident a

213 0 kea3 mutants, as these plants have a lower lumenal pH than cgl160 mutants, and thus show substantia

214 nus subdomain, which acts as a sensor of the lumenal pH, able to tune the quenching level of the comp

215 -free suspension medium caused a decrease of lumenal pH, eliminated by protonophore.

216 on flux was out of the LUV lumen, increasing lumenal pH.

217 al activity (Pi(1/2)/RT), decreased with the lumenal phosphate concentration.

218 overed multiple mutations clustered near the lumenal plug of Sec61alpha, thus revealing cotransin's l

219 hich localizes its interaction site near the lumenal plug of Sec61alpha.

220 wed that both a 20-amino acid stretch of the lumenal portion and a 10-amino acid stretch of the cytop

221 factor essential for proper assembly of the lumenal portion of the complex.

222 ted from the loss of a high concentration of lumenal potassium, which enabled the influx of potassium

223 Changes in lumenal pressure and size can influence the cell divisio

224 Our study reveals how lumenal pressure and tissue mechanics control embryo siz

225 We find that there is a twofold increase in lumenal pressure during blastocyst development, which tr

226 ed, cannulated, and pressurized to 55 cm H2O lumenal pressure without flow.

227 aired each cancer sample with matched benign lumenal prostate epithelial cells and profiled transcrip

228 ere we report that the chloroplast thylakoid lumenal protein MAINTENANCE OF PHOTOSYSTEM II UNDER HIGH

229 by examining the localization of non-mature lumenal proteins in the Arabidopsis plsp1-null mutant an

230 he observation of marked alterations in many lumenal proteins in the cs26 mutant compared with the wi

231 e multiple mechanisms to control unprocessed lumenal proteins in thylakoids.

232 plastids suggest that complete maturation of lumenal proteins is a critical step for proper thylakoid

233 h levels in pre-complexes lacking any of the lumenal proteins PsbP, PsbQ, or PsbV.

234 e not significantly altered by replacing all lumenal proteins with only protein disulfide isomerase o

235 In contrast, two other lumenal proteins, PsbU and PsbV, were absent in both of

236 degradation of both membrane-associated and lumenal proteins.

237 In contrast, the thylakoid lumenal proteome showed a wide diversity of N-terminal r

238 upling stoichiometrically to glutamate flux, lumenal protons and chloride allosterically activate ves

239 rize a chloride conductance that is gated by lumenal protons and chloride and supports glutamate upta

240 re was a significant amount of the extrinsic lumenal PsbO protein in the His27PSII, but not in the Hi

241 n-like domain of LTO1 interacts with PsbO, a lumenal PSII subunit known to be disulfide bonded, and a

242 s support a model in which MKS3 links the ER lumenal quality control machinery with the cytosolic deg

243 m homeostasis and suggest that modifying the lumenal redox environment may affect the progression of

244 ysteine cathepsins through modulation of the lumenal redox potential.

245 bunits (Emc1-6, Emc7 and Emc10), has a large lumenal region and a smaller cytosolic region, and has a

246 The US2 endoplasmic reticulum (ER)-lumenal region is the class I binding domain, whereas th

247 resent evidence for a potential role of this lumenal region of ATP7A in copper transfer to cuproenzym

248 weaning piglets modulates the composition of lumenal-residing gut microbiota and reduces weaning-rela

249 for the expression of epithelial CRBPII and lumenal retinoids to imprint local gut DCs with an intes

250 a barrier-independent function that promotes lumenal secretion of Vermiform and Serpentine, extracell

251 f a lumenal/apical extracellular matrix, and lumenal secretion of Vermiform and Serpentine, two putat

252 IC-3 mutants lacking the signal peptide, the lumenal segment or the coiled-coil domain, but not in mu

253 mammalian cells and discovered that (1) two lumenal sensors of misfolded ER proteins, the kinase/nuc

254 ctions of its B subunit, PltB, with specific lumenal sialylated glycan packaging receptors.

255 aries and scavenge microparticles from their lumenal side in a steady state.

256 ed by the Mn(4)CaO(5) cluster located at the lumenal side of PS II.

257 by binding to the extrinsic proteins on the lumenal side of PSII, which differ significantly between

258 hat retrotranslocation is coordinated on the lumenal side of the ER membrane.

259 idine and methionine residues located on the lumenal side of the membrane.

260 en-evolving complex, which is located on the lumenal side of the PSII reaction center and which conta

261 oplasmic side of the ER and completed on the lumenal side, requiring flipping of the intermediate Man

262 ch connect pairs of grana membranes at their lumenal sides.

263 Rather, it is a lumenal signal that sorts protein into clefts, which the

264 Addition of Ca(2+) to isolated lumenal silk resulted in Ca(2+) complexation by H-fibroi

265 Ca(2+) was also undetectable in anterior lumenal silk using the histochemical Ca(2+) indicator, a

266 (2+) activation and inactivation, and one SR lumenal site for CSQ binding.

267 t to exploitation of a hitherto unrecognized lumenal source of H2O2 by PRDX4 and a parallel slow H2O2

268 isplays microvilli and a primary cilium; its lumenal space is rich in Ca(2+) Time-lapse imaging of is

269 the decreased proton motive force within the lumenal space partially explain the variations observed

270 splitting of membranes and encloses a single lumenal space.

271 aling epidermal, myoepithelial-specific, and lumenal-specific injuries.

272 ing mapped to a seven-residue stretch in its lumenal stem domain next to the transmembrane domain.

273 rting receptor sortilin interacting with the lumenal stem domain of GPP130.

274 nsable for its ability to respond to Mn, its lumenal stem domain was required and it had to be target

275 ealed an extensive network of human-specific lumenal structures containing erythrocytes, indicating f

276 maturation in melanocytes, requires a third lumenal subdomain and proteolytic processing that itself

277 letion analyses indicate that two N-terminal lumenal subdomains are necessary and sufficient for ILV

278 ER-associated degradation of a lumenal substrate, CPY*, is blocked in the absence of Pb

279 We conclude that this lumenal subunit is present in the vicinity of the CP43 p

280 Thus, we propose an exchange of lumenal subunits and cofactors during PSII assembly, in

281 (alphabetaTCR), we show that unassembled ER-lumenal subunits are rapidly degraded, whereas specific

282 tPA added extracellularly bound to the lumenal surface of fused granules.

283 e mammalian cilium protrudes from the apical/lumenal surface of polarized cells and acts as a sensor

284 ameter when vesicles fuse with the expanding lumenal surface.

285 ary epithelial cells (mMECs) progressed from lumenal to basal-like phenotypes based on expression of

286 site in the center of NPC1 blocks a putative lumenal tunnel linked to the SSD.

287 g the differential and faster dissolution of lumenal versus tissue-embedded coating owing to a dispar

288 Here, we show that lumenal vesicle fusion depends on the small GTPase RAL-1

289 plays a unique role in the regulation of MVB lumenal vesicle size, whereas Vtal and Vps60 promote eff

290 hich target ubiquitylated receptors to intra-lumenal vesicles (ILVs) of multivesicular bodies, are th

291 PIN1 was detected in MVB lumenal vesicles of control cells but remained in the li

292 s integral membrane proteins sorted into the lumenal vesicles of late-endosomal multivesicular bodies

293 and targeted for degradation are sorted into lumenal vesicles of multivesicular bodies (MVBs) by the

294 inclusion of transmembrane proteins into the lumenal vesicles of multivesicular bodies (MVBs).

295 the vacuole/lysosome by directing them into lumenal vesicles of multivesicular bodies (MVBs).

296 ting of ubiquitinated membrane proteins into lumenal vesicles of multivesicular bodies is mediated by

297 ts ubiquitinated transmembrane proteins into lumenal vesicles of the compartment.

298 chmp1b mutant forms significantly fewer MVB lumenal vesicles than the wild type.

299 Here, we show that these native "lumenal vesicles" (LVs) (1) contain catalytically active

300 dictates an interaction between AAPN and the lumenal VP surface to nucleate capsid assembly.IMPORTANC