ライフサイエンスコーパス: lunatic

1 While Lunatic and Manic Fringe inhibit Notch1 activation from

2 We found that Lunatic and Manic Fringe modified similar sites on Notch

3 butors and contributions to, the West Riding Lunatic Asylum Medical Reports and compares these elemen

4 it is appropriate to regard the West Riding Lunatic Asylum Medical Reports as not only the anteceden

5 im might be challenged since the West Riding Lunatic Asylum Medical Reports, another journal with sig

6 ations at EGF6 and EGF36 (added by Manic and Lunatic but not Radical) inhibited Notch1 activation fro

7 used bone morphogenetic protein 4 (BMP4) and lunatic fringe (Fng) as molecular markers to identify th

8 th two other putative sensory organ markers, Lunatic Fringe (L-fng) and chicken Serrate1 (Ser1), both

9 We have shown here that Lunatic fringe (L-fng) expression is indicative of it be

10 helium, anteroposterior encroachment of alar lunatic fringe (L-fng) expression, and/or basal Shh sign

11 opus homologs of the Drosophila gene fringe, lunatic Fringe (lFng) and radical Fringe (rFng), were id

12 ntrally expressed otic genes such as NeuroD, Lunatic fringe (Lfng) and Six1 are shifted dorsally, whe

13 Lunatic fringe (Lfng) encodes a glycosyltransferase that

14 Lunatic fringe (LFNG) enhanced NOTCH2 activation by DLL1

15 We have investigated the role of Lunatic fringe (Lfng) expression during neurogenesis in

16 Lunatic fringe (Lfng) expression in the presomitic mesod

17 In mice, lunatic fringe (Lfng) expression oscillates, and LFNG pr

18 aevis and Danio rerio, include an absence of lunatic fringe (lfng) expression within the presomitic m

19 mponents of the Notch pathway, including the Lunatic fringe (Lfng) gene, are also expressed during di

20 ce homozygous for a targeted mutation of the lunatic fringe (Lfng) gene, one of the mouse homologues

21 e we have analyzed the reaction catalyzed by Lunatic Fringe (Lfng) in detail.

22 The Notch pathway and the Notch modulator Lunatic fringe (Lfng) play multiple roles during segment

23 narily conserved 2.3 kb region in the murine Lunatic fringe (Lfng) promoter that drives periodic expr

24 Lunatic Fringe (Lfng), a glycosyltransferase that enhanc

25 Here, we report that Lunatic fringe (Lfng), a key modifier of the Notch recep

26 d expression of the Notch target genes HEY1, lunatic fringe (LFNG), and ephrin-B2, reduced phosphoryl

27 report that expression of a Notch modulator, Lunatic Fringe (Lfng), is restricted to a limited number

28 ifferential regulation of Notch receptors by Lunatic Fringe (Lfng), which encodes an O-fucosylpeptide

29 es oscillatory expression of genes including Lunatic fringe (Lfng).

30 nistically linked by a process that requires lunatic fringe activity.

31 een a dorsal domain (dorsal roof) expressing lunatic fringe and Notch, and a ventral domain (posterio

32 We also identified pronephric expression of lunatic fringe and radical fringe that is temporally and

33 nge proteins in Chinese hamster ovary cells (Lunatic fringe and Radical fringe) as well as exogenous

34 ted that demonstrate that radical fringe and lunatic fringe are expressed in the granulosa cells of d

35 his study examines the distribution of chick lunatic fringe at sites of neural crest formation and ex

36 These results indicate that secreted lunatic Fringe can induce mesoderm and reveal that the F

37 further insight into the mechanism by which lunatic fringe controls somite development, we have cond

38 The gene lunatic fringe encodes a secreted factor with significan

39 tal plate prior to somite formation and that lunatic fringe expression cycles autonomously with a per

40 Recent observations of cyclic Lunatic fringe expression in chick and mouse embryos lin

41 nt, we have conducted a thorough analysis of lunatic fringe expression in the unsegmented paraxial me

42 new role for the Notch signaling pathway and lunatic fringe in mammalian folliculogenesis.

43 These findings point to a novel role for lunatic fringe in regulating cell division and/or produc

44 Expression of excess lunatic fringe in the cranial neural tube and neural cre

45 ols the periodic expression of genes such as lunatic fringe in the presomitic mesoderm.

46 Lunatic fringe is a vertebrate homologue of Drosophila f

47 Lunatic fringe is an important regulator of Notch signal

48 In addition, we show that lunatic fringe is expressed in a highly dynamic manner i

49 Shortly after neural tube closure, lunatic fringe is expressed in most of the neural tube,

50 Here we report that lunatic fringe is expressed predominantly in somite -II,

51 sruption in mouse embryos, we show here that lunatic fringe is likewise required for boundary formati

52 hough the beta 3GlcNAcT activity of manic or lunatic fringe is shown to be necessary for inhibition o

53 and heterodimerization of mutant Notch3 with Lunatic Fringe itself.

54 ic periodic expression pattern suggests that lunatic fringe may function to integrate notch signaling

55 ringe homologue and suggest a model in which lunatic fringe modulates Notch signalling in the segment

56 lunatic fringe mutants fail to form boundaries between i

57 axial skeleton, are severely disorganized in lunatic fringe mutants.

58 Lunatic fringe null female mice were found to be inferti

59 anscriptional level by clock elements in the lunatic fringe promoter.

60 The mature lunatic Fringe protein is secreted extracellularly, and

61 indirect reporter system, that the 3'UTR of Lunatic Fringe strongly destabilizes transcripts, while

62 Oscillations of lunatic fringe transcripts have now been shown to be con

63 Moreover, the murine ortholog of lunatic fringe undergoes a similar cycling expression pa

64 The remaining six transcripts [i.e., "lunatic fringe" (LFNG), mannose receptor C type 2 (MRC2)

65 LFNG (Lunatic Fringe) and MFNG (Manic Fringe) transfer N-acety

66 Lrrn1 also regulates the glycosyltransferase Lunatic Fringe, a modulator of Notch signalling, maintai

67 mologues have been identified, Manic fringe, Lunatic fringe, and Radical fringe.

68 Finally, together with the modulator lunatic fringe, Dll3 altered N signaling levels that wer

69 ure expression delays for three transcripts [Lunatic fringe, Hes7/her1, and Notch-regulated-ankyrin-r

70 ption in somite 0 requires the expression of lunatic fringe, which modifies the activation of the Not

71 Histological analysis of the lunatic fringe-deficient ovary demonstrated aberrant fol

72 Here we show that the Lunatic Fringe-GFP (Lfng-GFP) bacteria artificial chromo

73 ntation, including the novel secreted factor lunatic fringe.

74 cloned and characterized: Manic, Radical and Lunatic Fringe.

75 g1 and one of three paralogous Fringe genes: Lunatic (Lfng), Radical (Rfng), and Manic (Mfng).

76 hat expression of mammalian fringe proteins (Lunatic [LFng], Manic [MFng], or Radical [RFng] Fringe)

77 Lunatic, Manic, and Radical Fringe (LFNG, MFNG, and RFNG

78 Mammals have three Fringes: Lunatic, Manic, and Radical.

79 have demonstrated that, similar to Manic and Lunatic, Radical fringe is also a fucose-specific beta1,