ライフサイエンスコーパス: lung function

1 on atelectasis, thus optimizing the residual lung function.

2 -145-5p is a risk factor for ED of long-term lung function.

3 ew insights into the role of inflammation in lung function.

4 ing in increased inflammation and diminished lung function.

5 ols 20 smokers and 11 nonsmokers with normal lung function.

6 controller medication requirements, but not lung function.

7 attenuated the E. coli-induced compromise of lung function.

8 he largest, most recent genome-wide study of lung function.

9 ted in GWASs of COVID-19 hospitalization and lung function.

10 -up visit correlated with the improvement in lung function.

11 to discover genomic regions associated with lung function.

12 valuated associations of gamma-T levels with lung function.

13 differentiate into alveolar cells and rescue lung function.

14 mes, including changes in blood pressure and lung function.

15 e nose, upper and lower airway symptoms, and lung function.

16 tem asthma control questionnaire (ACQ-6) and lung function.

17 mucolytic erdosteine) or improvement only in lung function.

18 nts but cannot be used to directly determine lung function.

19 ts with a more aggressive rate of decline of lung function.

20 ndary to baseline risk factors, such as poor lung function.

21 airway inflammation, antiviral activity, and lung function.

22 83 SNPs that were previously associated with lung function.

23 exposure is associated with impaired infant lung function.

24 emonstrated resistance to subsequent loss of lung function.

25 siveness, airspace enlargements, and loss of lung function.

26 ression in the lungs and results in impaired lung function.

27 ulin replacement therapy tended to stabilize lung function.

28 ificant in subjects resistant to the loss of lung function.

29 ed in patients with lung cancer depending on lung function.

30 either COPD or population-based measures of lung function.

31 FEV(1)/FVC ratios in individuals with normal lung function.

32 Secondary outcome was longitudinal lung function.

33 some asthma-associated symptoms and reduced lung function.

34 g additional interdependence between BMI and lung function.

35 s were built using traditional predictors of lung function.

36 us load, illness severity, and reductions in lung function.

37 n-specific T(H)2 cells, were linked to worse lung function.

38 t immune cell infiltration at the expense of lung function.

39 od or in utero are associated with childhood lung function.

40 were used to compute longitudinal changes in lung function.

41 ele was associated with a 0.15-L increase in lung function (95% confidence interval, 0.08-0.21; P = 5

42 -3) ) and was also associated with change in lung function after treatment with ICS (P = 4.91 x 10(-3

43 the effects of DE and allergen coexposure on lung function, airway responsiveness, and circulating le

44 t seeks to examine genetic associations with lung function among continuous smokers in the Lung Healt

45 ic variants that may play a critical role in lung function among Puerto Rican youth.

46 ls and low CD4/CD8 are associated with lower lung function among youth living with perinatally-acquir

47 between short-term grass pollen exposure and lung function and airway inflammation in a community-bas

48 role of regulatory B cells in the control of lung function and airway remodeling and may support futu

49 SSESS scores also had greater improvement in lung function and asthma control after triamcinolone, bu

50 ly reduced severe exacerbations and improved lung function and asthma control in patients with type 2

51 Changes in lung function and B2AR number and signaling were similar

52 systemic inflammation is linked to impaired lung function and cardiovascular outcomes.

53 e-wide association studies (GWAS) studies of lung function and COPD have identified associated region

54 rmed whole genome sequence (WGS) analysis of lung function and COPD in a multi-ethnic sample of 11,49

55 Patients with MLN enlargement had lower lung function and decreased plasma concentrations of sol

56 were associated with significantly decreased lung function and decreased TMEM9 gene expression.

57 multivariable regression when adjusting for lung function and demographics.

58 ate the effects of rare SERPINA1 variants on lung function and emphysema phenotypes in subjects with

59 serum CC16 had significant deficits in their lung function and enhanced airway hyperresponsiveness to

60 , CC16(-/-) mice had significant deficits in lung function and enhanced airway hyperresponsiveness to

61 s in TLR5 and CCR1 are associated with lower lung function and faster decline in FEV(1) over 10 years

62 t entry, with higher average age, weight and lung function and fewer pulmonary exacerbations annually

63 Relationships between NO(2) levels and lung function and fractional exhaled nitric oxide did no

64 Spirometry testing was used to measure lung function and gene expression levels were measured u

65 Impaired lung function and impaired hearing are both criteria for

66 d provide a promising approach to preserving lung function and improving clinical outcomes following

67 Higher GRS was associated with lower lung function and increased COPD risk, as well as lower

68 f lung development genes in regulating adult lung function and influencing both restrictive and obstr

69 Finally, patients with severe CFLD had worse lung function and nutritional status than other CF patie

70 from COVID-19, particularly those with poor lung function and obesity.

71 indings suggest that the association between lung function and physical activity in older adults is m

72 potential therapeutic targets for improving lung function and possibly smoking cessation, although l

73 serves lung alveolar and vascular growth and lung function and prevents RVH after intrauterine ETX ex

74 e of airway remodelling, as well as improved lung function and reduced key pharmacodynamic biomarkers

75 long-acting beta(2)-agonist therapy improves lung function and reduces exacerbations.

76 channel beta subunit is required for normal lung function and resilience to ischemia and reperfusion

77 CNQ1 in the lungs and is required for normal lung function and resistance to pulmonary IRI.

78 TGA on FDG PET-CT was associated with worse lung function and respiratory symptoms prior to ART init

79 sis model, 5d from the series improved mouse lung function and slowed the progression of pulmonary fi

80 inistration of pegylated IFN-lambda improves lung function and survival during influenza by reducing

81 Both included normal lung function and the absence of symptoms, exacerbations

82 uncovered a novel role of Kv11.1 channels in lung function and their potential as new drug targets in

83 acetaminophen use and adolescent asthma and lung function and to assess potential interactions by GS

84 ted States, White adults have better average lung function and worse hearing than Black adults.

85 from high disease activity and showed better lung functions and lower levels of eosinophils and T(H)

86 Frequent comparisons of symptoms, lung function, and blood eosinophil counts revealed diff

87 variants on alpha-1 antitrypsin deficiency, lung function, and emphysema, thus significantly increas

88 n infected asthmatic subjects who had normal lung function, and in those receiving anti-IgE.

89 all-cause and respiratory hospitalizations, lung function, and plasma cytokine concentrations.

90 ine enhances mucociliary clearance, improves lung function, and reduces pulmonary exacerbations in pe

91 llular composition of BAL, lung, and spleen, lung function, and T-cell polarization were assessed.

92 s in pulmonary inflammation and decreases in lung function are common on ART, relate to greater ART-m

93 sts and fibrosis, but methods for evaluating lung function are limited to whole lung rather than spec

94 crobial peptide cathelicidin and recovery of lung function as assessed by the percentage of predicted

95 ass index (BMI; weight (kg)/height (m)2) and lung function as paired, within-person outcomes, we test

96 ncrease in BMI exhibit more rapid decline in lung function, as measured by forced expiratory volume i

97 s visit, basic asthma examinations including lung function, as well as questionnaires for health-rela

98 d to circulating inflammatory biomarkers and lung function assessed by spirometry pre- and post-ART i

99 widely used in routine clinical examination, lung function assessment, asthma and chronic obstructive

100 une-related and other pleiotropic effects of lung function-associated variants.

101 ecially in boys, and prematurity with poorer lung function at 17.5 years were found.

102 ticipants in the Project Viva cohort who had lung function at a mid-childhood visit (age 6-10 years).

103 average prenatal carbon monoxide and infant lung function at age 30 days, first in the entire cohort

104 esult in small but significant reductions in lung function at age 8 years.

105 espiratory health.Objectives: To investigate lung function at ages 8 and 15 years in relation to air

106 SuStaIn placed 30% of smokers with normal lung function at elevated stages, suggesting imaging cha

107 ic subunit delta) sites were associated with lung function at enrollment (P < 0.05).

108 ood alpha-T level was associated with better lung function at mid-childhood.

109 experienced worsening lung inflammation and lung function at Week 4 of ART.

110 Symptoms, pre-/post-bronchodilator lung function, atopy, and cleaning exposures were assess

111 ere used to compare longitudinal measures of lung function between the treatment groups.

112 ences were seen in quality-of-life scores or lung function between the treatment groups.Conclusions:

113 osinophils, neutrophils, FeNO), clinical and lung function biomarkers (PEF, FVC,FEV(1)), we estimated

114 possible effects of environmental factors on lung function, but none has relied on an exposome approa

115 tors of asthma remission, including baseline lung function, can be seen from an early age.

116 lungs results in significant improvements in lung function, cellular regeneration, and the developmen

117 arly markers of asthma exacerbations such as lung function changes and increase in airway inflammatio

118 unction (plasma fibrinogen concentration and lung function), cognitive performance (memory, executive

119 These children had worse pre-bronchodilator lung function compared with asthmatics without sensitiza

120 to chronic obstructive pulmonary disease and lung function.Conclusions: This work identifies a novel

121 ored candidate rare variants associated with lung function.Conclusions: We identified common and rare

122 Alterations in lung function consistent with these histopathologic chan

123 odels, stratified by sex, in a subgroup with lung function data (n = 3,575).

124 h worsen lung inflammation and contribute to lung function decline and acute exacerbation.

125 possible, to treat and result in accelerated lung function decline and premature death.

126 Aging promotes lung function decline and susceptibility to chronic lung

127 w-intensity current smokers have accelerated lung function decline compared with never-smokers, inclu

128 w-intensity current smokers have accelerated lung function decline compared with never-smokers.

129 hese marks were associated with longitudinal lung function decline in survivors, smoking history, or

130 The only group with a significant lung function decline over time were participants with I

131 ons: DBP exposure augmented allergen-induced lung function decline, particularly in those without bas

132 omycin use in PA-positive patients to reduce lung function decline.

133 ges in peripheral leukocytes correlated with lung function decline.Conclusions: Coexposure to DE and

134 Inhibitor-treated mice show amelioration of lung function, decreased alveolar epithelial cell apopto

135 several exposures were also associated with lung function deficits (P < .05).

136 erase (GST) family may protect against these lung function deficits.Objectives: To assess the long-te

137 ss 2 represented severe asthma with impaired lung function despite high doses of steroids.

138 igates the progression of BLM-induced PF and lung function deterioration.

139 ough elevated air pollution exposure impairs lung-function development in childhood, it remains a cha

140 siological changes that cause alterations in lung function, diminished pulmonary remodeling and regen

141 e for shared causal genetic variants between lung function, DNA methylation, and gene expression by u

142 LPCAT1 is crucial for proper lung function due to its role in pulmonary surfactant bi

143 ted inversely with inflammation and weakened lung function during COPD progression.

144 ests (PFTs) are needed for the assessment of lung function during disease management.

145 irway hyperresponsiveness, and reductions in lung function during rhinovirus infection.

146 Lung function, early allergic response, airway responsiv

147 ing transcripts and coexpression networks to lung function, emergency department visits or hospitaliz

148 dy-mass index and fat mass, hypertension and lung function, even after adjustment for population stru

149 There were no differences in age, gender, lung function, exercise capacity and quantitative comput

150 r, eczema, food allergy), and measurement of lung function, FeNO and specific IgE.

151 re were no significant changes at 8 weeks in lung function, FeNO or blood eosinophils.

152 ldren from Cluster 4 had a significant lower lung function (FEV(1) , FVC), higher FeNO and higher ris

153 Cleaners overall had lower lung function (FEV(1) , FVC; P < .05).

154 ene expression levels of these six genes and lung function (Forced Expiratory Volume in one second (F

155 ouncil dyspnea scale score >1), and impaired lung function (forced vital capacity <=75% predicted) co

156 rimary end point respiratory-related events, lung function (forced vital capacity and gas transfer),

157 lly susceptible to COVID-19, and compromised lung function from COVID-19 could also put at risk those

158 tobacco exposure is associated with reduced lung function from infancy.

159 d evidence of shared causal variants between lung function, gene expression, and DNA methylation.

160 neutrophils in asthma associated with lowest lung function, greater healthcare utilization, and longi

161 lergen exposure reduction is associated with lung function growth in mouse-sensitized/exposed asthmat

162 145-5p is associated with the ED patterns of lung function growth leading to COPD in children with as

163 n with asthma would be prognostic of reduced lung function growth patterns over the next 16 years.

164 ntial expression between previously assigned lung function growth patterns.

165 ung function parameters at 15 years and with lung function growth rates from 8 to 15 years were asses

166 Longitudinal lung function growth trajectories of children with asthm

167 iated DNA methylation has a causal effect on lung function has not been thoroughly evaluated.

168 icular polymorphisms, and possible impact on lung function, have never been investigated in adolescen

169 rns of wheezing, allergic sensitization, and lung function identified five respiratory phenotypes amo

170 x-specific effects of prenatal challenges on lung function, immune response, and asthma severity in m

171 The severity of lung function impairment was associated with Aspergillus

172 have chronic respiratory symptoms and severe lung function impairment, and an increased risk of acute

173 sociated with a history of hospitalizations, lung function impairment, and numbers of neutrophils and

174 ten had chronic respiratory symptoms, severe lung function impairment, asthma, and a history with bro

175 nderlying mechanisms is critical to mitigate lung function impairment.

176 anslates to protection from allergen-induced lung function impairment.

177 axis and previously demonstrated benefits of lung function improvement in SARS-CoV infections, it has

178 maining 35 new loci, 13 were associated with lung function in 79,055 individuals from the SpiroMeta c

179 ower birth weight are associated with poorer lung function in a non-western developed setting with le

180 ories, and their asthma-related outcomes and lung function in adolescence.

181 a possible link of LBW in humans and reduced lung function in adulthood.

182 nd Candida albicans, is associated with poor lung function in adults with severe asthma.

183 an association between physical activity and lung function in all smoking groups, with stronger assoc

184 al lifestyle and environmental exposures and lung function in children.

185 iations reported between body mass index and lung function in children.

186 ed weight loss, tachycardia, and compromised lung function in E. coli-exposed mice.

187 upstream of KCNE2 is associated with reduced lung function in human populations, but the pulmonary co

188 associated with the persistent impairment of lung function in individuals with HIV/TB.

189 kedly reduces the extent of PF and preserves lung function in mice following BLM treatment.

190 eased alveolar simplification, and preserved lung function in mice reaching adulthood.Conclusions: Na

191 accelerometer-derived physical activity and lung function in older adults differs by smoking history

192 mmation and slowing the long-term decline of lung function in patients with cystic fibrosis.

193 Rationale: Declining lung function in patients with interstitial lung disease

194 3) monoclonal antibody lebrikizumab improves lung function in patients with moderate-to-severe uncont

195 ss and characterize respiratory symptoms and lung function in professional cleaners, and determine po

196 ought to uncover the genetic architecture of lung function in Puerto Rican youth with and without ast

197 ntiretroviral therapy, suggesting a role for lung function in TB-IRIS definitions.

198 euroimmune unit as a critical determinant of lung function in the context of COVID-19, inflammatory c

199 We studied gene expression levels and lung function in the Coronary Artery Risk Development in

200 There was also superior lung function in the rotated group.

201 a exacerbation risk but not with symptoms or lung function in urban children; further studies to eval

202 Rationale: Deficits in infant lung function-including the ratio of the time to reach p

203 e Study on the influence of Air pollution on Lung Function, Inflammation and Ageing cohort in Germany

204 ng-term effect of in utero smoke exposure on lung function into adulthood, and to assess whether GSTT

205 Reduced lung function is associated with overall and cardiovascu

206 The relationship between body weight and lung function is complex.

207 A deterioration in lung function is driven by neoplastic growth of atypical

208 Impaired lung function is often caused by cigarette smoking, maki

209 he association between physical activity and lung function is thought to depend on smoking history bu

210 lmonary disease (COPD), diagnosed by reduced lung function, is a leading cause of morbidity and morta

211 st treatment year seems to predict the later lung function level.

212 In addition, we evaluated lung function longitudinally up to 48 weeks after ART in

213 ht gain are associated with greater rates of lung function loss.

214 Altered infant lung function may increase risk for pneumonia in the fir

215 s were used to study the association between lung function measured at year 30, 10-year decline from

216 hildren's Respiratory Study birth cohort had lung function measured by the chest-compression techniqu

217 firmed by 2 independent techniques: invasive lung function measurement in vivo and examination of pre

218 Lung function measurements and nasal epithelial gene-exp

219 ing beta(2)-agonist (LABA) treatment on both lung function measures of hyperinflation, and the nasal

220 ts, incorporating domains of asthma control, lung function, medications, and exacerbations.

221 ng a well-established rat model, we compared lung function, mesenchymal markers of airway reactivity,

222 notypes have long-term protective effects on lung function.Methods: In this longitudinal study based

223 e effects of lung development genes on adult lung function.Methods: Using UK Biobank data, we tested

224 DDTL have been described in GWAS for COPD or lung function, MIF expression in COPD patients is more l

225 pendently associated with persistently lower lung function months after TB treatment completion.

226 AZD9412 improved lung function (morning peak expiratory flow; mPEF) by 19

227 improved peripheral lymphadenopathy (n = 2), lung function (n = 1), thrombocyte counts (n = 1), and c

228 ed a high-risk cluster characterized by poor lung function, nutritional status, and exercise capacity

229 erculosis experienced meaningful declines in lung function on antiretroviral therapy, suggesting a ro

230 ficant symptoms by validated instrument, (2) lung function optimization/stabilization, (3) patient/pr

231 measures were independently associated with lung function or asthma.Conclusions: The obesity-asthma

232 ut failed to enhance IL-13-driven effects on lung function or goblet cell metaplasia.

233 ctives: To test the hypothesis that impaired lung function or lung disease in midlife is associated w

234 asthma control and quality of life, but not lung function or type 2 biomarkers.

235 o association with asthma severity, baseline lung function, or asthma control was identified.

236 ificant differences in other event outcomes, lung function, or patient-reported outcomes.

237 monary exacerbation, 12-mo mortality, serial lung function, or serial plasma cathelicidin concentrati

238 tion between distance to a major roadway and lung function outcomes.

239 HIV+ adolescents had lower lung function over 2 years than HIV- adolescents.

240 There is limited information on changes in lung function over time in perinatally HIV+ adolescents

241 Changes in lung function over time were modeled, adjusting for age,

242 ong tracking of asthma activity and impaired lung function over time.

243 bove traditional ARDSnet settings to improve lung function, oxygenation and ventilation/perfusion mat

244 these trajectories with post-bronchodilation lung function parameters at 15 years and with lung funct

245 0, and miR-34a significantly correlated with lung function parameters in children (FEV(1) FVC(%pred)

246 nist inhalation and the correlation with the lung function parameters were clear during resting breat

247 001 may have a rapid and sustained effect on lung function, particularly in patients with type 2 phen

248 Predefined sensitivity analyses based on lung function, Pseudomonas aeruginosa (PA) status, and f

249 hown to reduce asthma exacerbations, improve lung function, reduce oral corticosteroid use, and impro

250 CXCR4 agonists at doses that preserved lung function reduced histological injury of the post-is

251 ginosa was not independently associated with lung function (regression coefficient -4.77, 95% CI -10.

252 Shifts in sweat chloride concentration and lung function reported in CFTR modulator trials were com

253 ensitized to thermotolerant fungi have worse lung function, require more courses of systemic corticos

254 re found between the predicted postoperative lung function results derived from these methods and the

255 Lung function revealed a mixed obstructive-restrictive i

256 ant- and food-allergic sensitization, asthma lung function scores was obtained from 855 10-year-old c

257 s with allergic asthma and relatively normal lung function, separated by contrasting sputum neutrophi

258 nduction of blocking IgG, and improvement of lung function, superior compared to the effects of subcu

259 This study highlights the need for lung function surveillance and prevention of LRTIs and P

260 ), three different clusters covering asthma, lung function, symptoms in the previous 4 weeks and age

261 5 adults with paired measurements of BMI and lung function taken at >=3 visits were selected from a p

262 Airway oscillometry is a lung function test that detects peripheral airway inhomo

263 There were no significant changes about lung function test, smoking history, sex and the levels

264 detailed questionnaires, allergy tests, and lung function tests and were reassessed annually for 3 y

265 or (sIL-6R) to asthma severity and decreased lung function, the role of IL-6 trans-signaling (IL-6TS)

266 th symptoms had similar antigen exposure and lung function, they had higher KL-6 than those without,

267 The influence of B cells on lung function, tissue remodeling, and the immune respons

268 n-idiopathic pulmonary fibrosis ILD and used lung function to determine the greatest risks of death.M

269 It is widely used in the assessment of lung function to provide objective information used in t

270 isease (COPD) can develop not only through a lung function trajectory dominated by an accelerated dec

271 dhood asthma therapies have little effect on lung function trajectory.

272 idiopathic pulmonary fibrosis and preserved lung function, treatment with nintedanib versus placebo

273 Changes in lung function, urinary eicosanoids, plasma tryptase, pla

274 Free-breathing proton MRI may help quantify lung function using existing MRI systems without contras

275 ) were found between predicted postoperative lung function values according to SC, PS, SPECT/CT, and

276 and without lung cancer across a spectrum of lung-function values.

277 NA methylation at some sites might influence lung function via effects on smoking.

278 s with the CT/TT genotypes also had improved lung function vs CC patients up to 48 weeks post-ART ini

279 Lung function was assessed longitudinally from 6 to 24 y

280 Lung function was assessed using spirometry.

281 At Day 14, lung function was assessed, and tissues were harvested t

282 Lung function was compared after transplant among the gr

283 Following aerosol challenges, lung function was determined by whole-body plethysmograp

284 4 years differed between phenotypes, whereas lung function was lower among persistent wheezers.

285 At the same time, their lung function was measured by a spirogram and the forced

286 Lung function was measured by spirometry.

287 udy based on a general population (n = 253), lung function was measured during infancy and at 6, 11,

288 d blood eosinophil counts were augmented and lung function was reduced among allergic asthmatics earl

289 Lung function was significantly diminished in the FE tra

290 ell responses on ART, and early decreases in lung function were independently associated with persist

291 Asthma and lung function were measured at 12 (n = 365 [58.9%]) and

292 toms, morbidity, pulmonary inflammation, and lung function were monitored throughout the subsequent a

293 t age 15 years, no adverse associations with lung function were seen.Conclusions: Exposure to road-tr

294 g omalizumab on reducing LRTSs and improving lung function were strongest over the first 4 days.

295 ions: Coexposure to DE and allergen impaired lung function, which was worse after particle depletion

296 may open a new way to non-invasively explore lung function while providing improved diagnosis of loca

297 Increasing impairment in lung function with age was found among biomass users (p-

298 nvestigated the relationship between LBW and lung function with Mendelian randomisation analyses and

299 We assessed the association of lung function with overall 8-year mortality in 867 indiv

300 : We estimated that substantial increases in lung function would occur as a result of interventions t