ライフサイエンスコーパス: lyase

1 polyphenol oxidase and phenylalanine ammonia-lyase).

2 polymannuronate specific endolytic alginate lyase.

3 nservation, comprises the active site of the lyase.

4 tamate dehydrogenase and cystathionine gamma-lyase.

5 f structural similarity to that of human ADS lyase.

6 which encodes sphingosine-1-phosphate (S1P) lyase.

7 standing of the mechanism of this novel C-As lyase.

8 essential glycyl radical on pyruvate formate-lyase.

9 corbate peroxidase and phenylalanine ammonia-lyase.

10 ached to the protein chain by specific bilin lyases.

11 tion and substrate specificities of alginate lyases.

12 new kind of catalytic mechanism of alginate lyases.

13 Km values that have been noted for some DMSP lyases.

14 lycans are desulfated before cleavage by the lyases.

15 otechnological applications of PL36 alginate lyases.

16 hibiting the enzyme, sphingosine-1-phosphate lyase 1 (SPL), has neuroprotective effects in Huntington

17 mes by knocking down cytochrome c/c (1) heme lyase 1 (TgCCHL1), a mitochondrial enzyme that catalyzes

18 sine kinase 1 and 2, sphingosine-1-phosphate lyase 1, and sphingosine-1-phosphate phosphatase 1 in no

19 Inhibition of tyrosine phenol-lyase, a bacterial enzyme responsible for the synthesis

20 isparate distribution for rhamnogalacturonan lyase, a secondary pectinase hydrolyzing the pectic hete

21 Here we showed that ATP-citrate lyase (ACL), an enzyme converting citrate to acetyl-CoA,

22 d variants in the genes encoding ATP citrate lyase (ACLY) and HMGCR to create instruments that mimic

23 etabolite profiling, we identify ATP-citrate lyase (ACLY) as a distinctly mTORC2-sensitive AKT substr

24 The ATP citrate lyase (ACLY) enzyme cleaves cytosolic citrate to generat

25 tyl CoA (Ac-CoA), is produced by ATP-citrate lyase (ACLY) from mitochondria-derived citrate or by ace

26 utaryl-CoA reductase (HMGCR) and ATP-citrate lyase (ACLY) in a TGF-beta receptor/PI3K/protein kinase

27 ATP-citrate lyase (ACLY) is a central metabolic enzyme and catalyses

28 ATP-citrate lyase (ACLY) is a major source of nucleocytosolic acetyl

29 is study, we report that nuclear ATP-citrate lyase (ACLY) is phosphorylated at S455 downstream of ata

30 ATP-citrate lyase (ACLY) synthesizes cytosolic acetyl coenzyme A (ac

31 Here, we show ATP citrate lyase (Acly) to be activated in inflammatory macrophages

32 ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, is frequ

33 ), acetyl-CoA carboxylase (ACC), ATP citrate lyase (ACLY)].

34 (ACCalpha), and increased FASN, ATP citrate lyase(ACLY), and malic enzyme (ME) protein expression in

35 hemistry (nitrotyrosine, cystathionine gamma-lyase, activated caspase-3, and extravascular albumin),

36 activities of two enzymes: pyruvate formate lyase activating enzyme (coded by pflA) and pyruvate for

37 Pyruvate formate-lyase activating enzyme (PFL-AE) is a radical S-adenosyl

38 induced ET in the RS enzyme pyruvate formate-lyase activating enzyme cleaved the S-C5' bond to genera

39 e data suggest that the three lysines in the lyase active site destabilize pol beta when bound to DNA

40 hat mutation of three lysine residues in the lyase active site of pol beta, 35, 68, and 72, to alanin

41 Indeed, the lyase-active enzyme has 3 orders of magnitude higher aff

42 d their DNA cleavage, DNA glycosylase and AP lyase activities in vitro at 37 degrees C.

43 ially blocking the 17alpha-hydroxylation and lyase activities of the enzyme.

44 led to the hypothesis that the isomerase and lyase activities performed by the MST enzymes are functi

45 Some DNA glycosylases possess AP lyase activities that nick the DNA strand at the deoxyri

46 easing isocitrate lyase and methylisocitrate lyase activities.

47 enzyme with 17-alpha-hydroxylase and C17,20-lyase activities.

48 1) glycosylase activity (C146 and C255), (2) lyase activity (C140S, C163, C241, and C253), and (3) st

49 t was deficient in soluble secreted alginate lyase activity and in digestion of and growth on alginat

50 icant decreases in the phenylalanine ammonia-lyase activity and significantly increases of peroxidase

51 ytochrome b (5) partially enhances P450 17A1 lyase activity by altering the P450 17A1 conformation bu

52 13B01, exhibited high extracellular alginate lyase activity compared with other V. splendidus strains

53 temperature while another showed its weak AP lyase activity generates atypical ends.

54 The AP lyase activity is more coupled with glycosylase activity

55 Thus, the lyase activity of hNTHL1, and the 3' diesterase activity

56 es, APE1 completely bypasses the inefficient lyase activity of NTHL1.

57 However, the lyase activity of purified pol gamma was weak against th

58 On the other hand, the 5'-dRP lyase activity of the exon alpha Pol beta variant is sim

59 isochorismoyl-glutamate A pyruvoyl-glutamate lyase activity that produces SA from the isochorismoyl-g

60 clude that zebrafish P450 17A2 is capable of lyase activity with the 17alpha-OOH steroids because it

61 r pathways via its DNA glycosylase and/or AP lyase activity, which are considered canonical roles of

62 tner, cytochrome b5, required for CYP 17A1's lyase activity.

63 s modification inhibits its phosphothreonine lyase activity.

64 volving fatty acid oxidation and ATP-citrate lyase activity.

65 e dispensable for its DNA glycosylase and AP lyase activity; however, the potential function of the N

66 s spectrometry, we identify adenylosuccinate lyase (ADSL) as an EglN2 hydroxylase substrate in triple

67 EroS is a chondroitin lyase; although its substrate, chondroitin sulfate, was

68 Here, we characterized a novel PL36 alginate lyase, Aly36B, from Chitinophaga sp. MD30.

69 Homogalacturonan solubilization by pectate lyase and calcium chelation greatly increased the indent

70 The activities of pol beta lyase and FEN1 nucleotide excision were able to remove t

71 DddY is the only known periplasmic DMSP lyase and is present in beta-, gamma-, delta- and epsilo

72 ngement, substantially increasing isocitrate lyase and methylisocitrate lyase activities.

73 hat two pectin modification genes, a pectate lyase and pectinesterase, are targets of both bHLH trans

74 2498c as a bifunctional beta-hydroxyacyl-CoA lyase and that deletion of the rv2498c gene from the Mtb

75 Ammonia-lyases and aminomutases are mechanistically and structur

76 In most cases, DMSP lyases and DMSP demethylases (DmdAs) have low substrate

77 lyase, broadening our knowledge on alginate lyases and facilitating future biotechnological applicat

78 ning method is demonstrated for both ammonia lyases and P450 monooxygenases expressed within live bac

79 echanism of action between HS epimerases and lyases and provide molecular frameworks for the chemoenz

80 nt enzymatic challenge to the polysaccharide lyases and sulfatases that mediate degradation.

81 ed for bempedoic acid (targeting ATP-citrate lyase) and inclisiran (an interference RNA-based therape

82 X (lipoxygenase), PAL (phenylalanine ammonia lyase), and PR-1 (pathogenesis related protein 1) after

83 ches a biliverdin (BV) chromophore without a lyase, and has 642/670-nm excitation-emission peaks, a l

84 uch as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1.

85 s oxidoreductases, transferases, hydrolases, lyases, and ligases.

86 heparin, non-anticoagulant heparin, heparin lyases, and lung heparan sulfate potently block spike pr

87 are ligated to specific cysteines via bilin lyases, and some of these enzymes, called lyase isomeras

88 NEIL2 usurps the canonical lyase, APE1, at abasic sites in a purified BER system, r

89 additionally endowed with rhamnogalacturonan lyase appear to utilize a broader diversity of angiosper

90 nd characterized so far, and the other bilin lyases are unknown.

91 ssing Brevibacterium linens methionine-gamma-lyase (BlMGL) produced the sulfur volatile compound dime

92 e and catalytic mechanism of a PL36 alginate lyase, broadening our knowledge on alginate lyases and f

93 line not only induces choline-trimethylamine lyase but also genes encoding shell proteins for the for

94 e bHLH transcription factors and the pectate lyase, but not for the pectinesterase, complement water

95 structural biology that this cysteine-thiol lyase (C-T lyase) is a PLP-dependent enzyme that moved h

96 Alginate lyases can be used for alginate oligosaccharide producti

97 can achieve an appropriate conformation for lyase catalysis in this system that is precluded in the

98 obutyrate and ammonia by cystathionine gamma-lyase (CGL) in the reverse transsulfuration pathway.

99 In contrast to N. ulvanivorans ulvan lyase, cleavage occurred specifically at the GlcUA resid

100 Bacterial DMSP lyases cleave DMSP, producing acrylate and dimethyl sulf

101 enzyme (coded by pflA) and pyruvate formate lyase (coded by pflB).

102 The structure of the C-T lyase compared to that of other related enzymes reveals

103 CCMF(C), which is presumed to form the heme lyase component of the cytochrome c maturation pathway.

104 r metabolic disease; rather than disrupt ADS lyase, compounds that improve the stability the enzyme m

105 Cysteine lyase contains haem and pyridoxal 5'-phosphate co-factor

106 In nucleosomes, the NTHL1-associated lyase contributes to BER, even in the presence of APE1.

107 CpeB and together with other specific bilin lyases contributes to the post-translational modificatio

108 a similar fold as the cyanobacterial T-type lyase CpcT from Nostoc sp. PCC7120 but overall is more c

109 peB or MpeB is first chromophorylated by the lyase CpeS (which adds phycoerythrobilin to C82).

110 However, it could assist the host lyase CpeS in its function by providing a pool of readil

111 Inhibition of both cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), 2 maj

112 Cystathionine gamma-lyase (CSE) catalyzes H(2)S synthesis and is a potential

113 beta synthase (CBS) and cystathionine gamma lyase (CSE) enzymes.

114 (H(2)S) by inhibition of cystathionine gamma-lyase (CSE) increases sFlt-1 and soluble endoglin (sEng)

115 and its synthetic enzyme cystathionine-gamma-lyase (CSE) is down-regulated in growth-restricted place

116 H2S-synthesizing enzyme cystathionine-gamma-lyase (CSE) normalized breathing in HO-2(-/-) mice.

117 steine metabolism by the cystathionine gamma lyase (CSE), generates hydrogen sulfide-related sulfane

118 Using cystathionine gamma-lyase (CSE)-deficient mice, we demonstrate an unexpected

119 or by overexpression of cystathionine gamma-lyase (CSE).

120 H2S)-synthesizing enzyme cystathionine-gamma-lyase (CSE).

121 Cystathionine gamma-lyase (CSE; also cystathionase), a principal hydrogen su

122 targets the gut microbial enzyme choline TMA-lyase (CutC).

123 Unlike other known DMSP lyases, DddY has not been classified into a protein supe

124 succinate synthetase 1 and argininosuccinate lyase deficiencies identified by newborn screening had b

125 Cystathionine gamma-lyase deficiency aggravates obesity-related insulin resi

126 ther two known DNPS defects-adenylosuccinate lyase deficiency and AICA-ribosiduria-the PAICS mutation

127 tability the enzyme may be used to treat ADS lyase deficiency disease.

128 An isocitrate lyase-deficient mutant of Mtb (Deltaicl1) exhibited a de

129 The reaction product generated by the lyase, Delta4,5-unsaturated uronic acid, is removed from

130 ferredoxin oxidoreductase / pyruvate-formate-lyase-dependent (rPFOR/Pfl) pathways.

131 cision repair, gap-filling DNA synthesis and lyase-dependent 5'-end deoxyribose phosphate removal.

132 first comprehensive report on LPS-degrading lyase derived from a Pseudomonas phage.

133 thening to approximately 140 nM for the full lyase domain (residues 2-87).

134 Lysines within the lyase domain are required for processive searching, reve

135 The lyase domain of pol beta has been proposed to function i

136 earching, revealing a novel function for the lyase domain of Pol beta.

137 ns a specific NLS sequence in the N-terminal lyase domain that promotes transport of the protein inde

138 on signal (NLS) may reside in the N-terminal lyase domain.

139 nts reported here are located within the FMN lyase domain.

140 4',5'-phosphate (cyclic FMN) through an FMN lyase domain.

141 Under anaerobic conditions, pyruvate formate-lyase enabled 2-ketobutyrate biosynthesis from propionyl

142 agenesis, we examined the role of a putative lyase-encoding gene, cpeF, in the cyanobacterium Fremyel

143 P/ADP, phospholipid content, and ATP citrate lyase expression.

144 Here, we genome-mined a polysaccharide lyase family 6 alginate lyase from the gut bacterium Bac

145 al screening, we identified a polysaccharide lyase family 7 enzyme that is unique to V. splendidus 13

146 e crystal structure of a member of the novel lyase family revealed a catalytic domain that displays a

147 Here we have discovered a new polysaccharide lyase family that is specific for the l-rhamnose-alpha1,

148 Expression of a soluble heme lyase from an organism with cytochrome c maturation syst

149 ned a polysaccharide lyase family 6 alginate lyase from the gut bacterium Bacteroides cellulosilyticu

150 and biochemically characterized novel ulvan lyases from three Alteromonadales isolated bacteria.

151 ta catalyzes two key enzymatic steps: 5'-dRP lyase gap trimming and template-directed DNA synthesis.

152 nomes showed that the choline trimethylamine-lyase gene was overabundant in CRC (P = 0.001), identify

153 r6, a mutant defective in a putative pectate lyase gene.

154 in naked DNA, APE1 was able to process NTHL1 lyase-generated substrates just as efficiently as it pro

155 forms of RuBisCO, together with ATP citrate lyase genes in the rTCA cycle, increase with distance fr

156 xtracellular activity and lacks two alginate lyase genes present in V. splendidus 13B01.

157 In this study, five alginate lyase genes were cloned from Cellulophaga algicola DSM 1

158 Only two PE lyases have been identified and characterized so far, an

159 res or catalytic mechanisms of PL36 alginate lyases have yet to be revealed.

160 3-Hydroxy-3-methylglutaryl-CoA (HMG-CoA) lyase (HMGL) is involved in branched-chain amino acid ca

161 we engineered the human cystathionine-gamma-lyase (hMGL-4.0) to catalyze the selective degradation o

162 on of the gene neighbourhood of the alginate lyase homologues revealed distinct patterns depending on

163 rsibly inhibit human sphingosine-1-phosphate lyase (hS1PL) while behaving also as an enzyme substrate

164 t despite IGPS's classification as a carboxy-lyase (i.e. decarboxylase), decarboxylation is not a com

165 t enzyme of the glyoxylate shunt, isocitrate lyase (ICL), may mediate survival of Mtb during the acut

166 Isocitrate lyase (ICL, types 1 and 2) is the first enzyme of the gl

167 the oligosaccharides obtained after heparin lyase III digestion of the polysaccharide indicated two

168 Here, we report that ADE13 encodes ADS lyase in C. neoformans.

169 ATP and GTP, prompting us to investigate ADS lyase in C. neoformans.

170 port that CLYBL operates as a citramalyl-CoA lyase in mammalian cells.

171 nt with the annotation of rhamnogalacturonan lyase in Stammera, cassidines are able to depolymerize R

172 uccinate synthase (ASS1) and arginosuccinate lyase in UHCA.

173 nd new information about the role of pectate lyases in plant development forms the focus of this revi

174 The role of pectate lyases in plant development has received little attentio

175 sporter Slc25A1, and the nuclear ATP-citrate lyase, in association with intracellular accumulation of

176 rified EroS, and other bacterial chondroitin lyases induce S. rosetta mating at environmentally relev

177 hydroxycitrate, an inhibitor of ATP citrate lyase, induced the depletion of regulatory T cells (whic

178 doic acid, an adenosine triphosphate-citrate lyase inhibitor that reduces cholesterol synthesis, and

179 ruments that mimic the effect of ATP citrate lyase inhibitors and HMGCR inhibitors (statins), respect

180 ariants that mimic the effect of ATP citrate lyase inhibitors and statins appeared to lower plasma LD

181 s an antimicrobial target, C. neoformans ADS lyase inhibitors may also serve as potential therapeutic

182 as bacteria employ an isochorismate pyruvate lyase (IPL) that catalyzes the turnover of isochorismate

183 Spore photoproduct lyase is a radical S-adenosyl-l-methionine (SAM) enzyme

184 ATP citrate lyase is an enzyme in the cholesterol-biosynthesis pathw

185 ATP-citrate lyase is an epigenetic regulator to promote obesity-rela

186 es that infer phosphonate catabolism via C-P lyase is an important adaptive strategy implemented by b

187 hether the genetic inhibition of ATP citrate lyase is associated with deleterious outcomes and whethe

188 dour production, demonstrating that this C-T lyase is both necessary and sufficient for thioalcohol f

189 Isocitrate lyase is important for lipid utilisation by Mycobacteriu

190 We propose that a novel kind of ring-opening lyase is involved in the further catabolic pathway proce

191 biology that this cysteine-thiol lyase (C-T lyase) is a PLP-dependent enzyme that moved horizontally

192 yl radical enzyme (GRE), isethionate sulfite-lyase (IslA).

193 Our results show that MpeV is the lyase isomerase that covalently attaches a doubly linked

194 MpeV is a putative lyase isomerase whose role in PEI and PEII biosynthesis

195 in lyases, and some of these enzymes, called lyase isomerases, attach phycoerythrobilin and simultane

196 our understanding of the mechanisms guiding lyase isomerases.

197 th processes being attenuated by ATP-citrate lyase knockdown.

198 n of inducible sphingosine-1-phosphate (S1P) lyase knockout mice to specifically modulate sphingolipi

199 AlyA1, the only Z. galactanivorans alginate lyase known to be secreted in soluble form and to have a

200 (HFD) results in suppression of ATP citrate-lyase levels in tissues such as adipose and liver, but t

201 igO, and LigL) and the glutathione-dependent lyase LigG provide new insights into the early and late

202 zymes such as CELLULASE5 (CEL5) and a pectin lyase-like gene, as well as the root cap regulators SOMB

203 ive targets of XRN4 and VCS in seeds (PECTIN LYASE-LIKE, ASPARTYL PROTEASE, DWD-HYPERSENSITIVE-TO-ABA

204 the effector protein sphingosine-1 phosphate lyase (LpSpl) to target the host sphingosine biosynthesi

205 ificities and that the two exolytic alginate lyases mainly cleaved unsaturated guluronic acid oligosa

206 L36 sequences, suggesting that PL36 alginate lyases may adopt a similar catalytic mechanism.

207 The organomercurial lyase MerB has the unique ability to cleave carbon-Hg bo

208 ng-cleavage is achieved via hydratases, this lyase might represent a new ring-opening strategy for th

209 n the active site of N-acetylneuraminic acid lyase (NAL), and the resulting chemically modified enzym

210 nvestigate the bifunctional DNA glycosylases/lyases NEIL1 and NEIL2, which act in repair of oxidative

211 thionine beta-synthase duplication, cysteine lyase neofunctionalization and cysteic acid decarboxylas

212 r lifelong genetic inhibition of ATP citrate lyase nor lifelong genetic inhibition of HMGCR was assoc

213 Tryptophan lyase (NosL) is a radical S-adenosyl-l-methionine (SAM)

214 d 80% of them were produced by fungal pectin lyases, not by polygalacturonases.

215 The major function of O-acetyl-Ser-(thiol) lyase (OAS-TL; EC 2.5.1.47) is the formation of l-Cys, b

216 either the glyoxylate shunt (via isocitrate lyase) or the TCA cycle (via isocitrate dehydrogenase (I

217 Bacterial phosphothreonine lyases, or phospholyases, catalyze a unique post-transla

218 largely confined to the use of a select few lyases over the last several decades, limiting the types

219 lavonoid compositions, phenylalanine ammonia lyase (PAL) activity and antioxidant capacity were evalu

220 piration, weight loss, phenylalanine ammonia lyase (PAL) activity and ion leakage with the benefits b

221 ntration due to higher phenylalanine ammonia-lyase (PAL) and lower polyphenol oxidase (PPO) activitie

222 ransient expression of phenylalanine ammonia-lyase (PAL) and stilbene synthase (STS) genes, followed

223 concurrent with higher phenylalanine ammonia lyase (PAL) enzyme activity leading to higher total phen

224 ic relevance, five new phenylalanine ammonia lyase (PAL) enzymes were discovered and characterised wi

225 riptional activator of PHENYLALANINE AMMONIA-LYASE (PAL) genes which are required for SA biosynthesis

226 L-Phenylalanine ammonia-lyase (PAL) is the first enzyme in the biosynthesis of p

227 Phenylalanine ammonia-lyase (PAL) is the first enzyme of the general phenylpro

228 flowers expression of all three Phe ammonia lyase (PAL) isoforms that catalyze the non-oxidative dea

229 rismate via either the phenylalanine ammonia lyase (PAL) or the isochorismate synthase (ICS) catalyze

230 d 29W, the activity of phenylalanine ammonia lyase (PAL) was increased significantly (P<0.05) by 2.0

231 oxidase, catalase and phenylalanine ammonium lyase (PAL)) and non enzymatic (total phenolics, flavono

232 eptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL)) domains.

233 enol oxidase (PPO) and phenylalanine ammonia lyase (PAL).

234 th the yeast enzyme of phenylalanine ammonia lyase (PAL).

235 ion and degradation of phenylalanine ammonia lyase (PAL).

236 ion of the bacterial carbon-phosphorus (C-P) lyase pathway, an enzyme complex evolved to extract phos

237 ycine alpha-hydroxylating monooxygenase) and lyase (peptidyl-alpha-hydroxyglycine alpha-amidating lya

238 to depend upon two enzymes, pyruvate:formate lyase (PFL) and pyruvate:ferredoxin oxidoreductase (PFOR

239 and generates pyruvate, and pyruvate-formate lyase (PFL) converting pyruvate to formate and acetyl-Co

240 Pyruvate formate lyase (PFL) is a crucial enzyme for mixed acid fermentat

241 Further, two key genes encoding C-P lyase (phnJL, an important enzyme for dealkylation of MP

242 plied sciences, fall into ten polysaccharide lyase (PL) families.

243 lucosidase, beta-amylase, chitinase, pectate lyase (PL), pectinesterase (PE) and polygalacturonase (P

244 e bifunctional enzyme adenylosuccinate (ADS) lyase plays a role in the formation of the key intermedi

245 matic activities: glycosylase, endonuclease, lyase, polymerase, and ligase.

246 The three endolytic alginate lyases predominantly hydrolyzed guluronic acid-rich algi

247 genic plants overexpressing methionine-gamma-lyase produced dimethyl sulfide.

248 Thanks to the pectate lyases produced by bacteria cultivated in the vessel, th

249 ATP citrate-lyase produces acetyl-CoA in the nucleus and cytosol and

250 son of the efficiency of eight other pectate lyase-producing microorganisms with that of D. dadantii

251 and P450 17A2 readily converted these to the lyase products in the absence of other proteins or cofac

252 pha-hairpinin (Pru du 8), and mandelonitrile lyase (Pru du 10).

253 zymatic mechanism of this unprecedented C-As lyase reaction will enhance our understanding of recycli

254 ha-hydroxylation and a subsequent 17alpha,20-lyase reaction, and several mechanisms have been propose

255 e and 17alpha-hydroxypregnenolone 17alpha,20-lyase reactions of human P450 17A1 and found incorporati

256 d progesterone and the subsequent 17alpha,20-lyase reactions to form dehydroepiandrosterone (DHEA) an

257 ferase and for the EutA ethanolamine ammonia-lyase reactivase.

258 bempedoic acid, an inhibitor of ATP citrate lyase, reduces levels of low-density lipoprotein (LDL) c

259 ge P-HM1 encodes a putative phycobiliprotein lyase related to cyanobacterial T-type lyases, which fac

260 vities and is also unique by having three AP lyase repair sites in the same polypeptide.

261 The 5-methylcytosine DNA glycosylase/lyase REPRESSOR OF SILENCING 1 (ROS1)-mediated active DN

262 We conclude that CpeF is the bilin lyase responsible for attachment of the doubly ligated P

263 gulated, in part through the activity of S1P lyase (S1PL) which catalyses its irreversible degradatio

264 recently reported that seviteronel, a CYP17 lyase-selective inhibitor, aedemonstrated a sustained re

265 S1P lyase (SGPL1) knockout in either immune cells or tissue,

266 unction mutations in sphingosine-1-phosphate lyase (SGPL1).

267 Purified recombinant C. neoformans ADS lyase shows catalytic activity similar to its human coun

268 The 3rd AP lyase site is located in the 12th (HhH)2 domain.

269 A recombinant putative cystathionine gamma-lyase (smCSE) mineralizes CdS from an aqueous cadmium ac

270 show an O5 serotype-specific polysaccharide lyase specificity.

271 Sphingosine 1-phosphate (S1P) lyase (SPL) is an intracellular enzyme that mediates the

272 -specific knockout mouse models in which S1P-lyase (SPL), the enzyme responsible for irreversible S1P

273 enchymal S1P levels are kept low through S1P lyase (SPL)-mediated metabolism.

274 manipulating the S1P-metabolizing enzyme S1P lyase (SPL).

275 rocessivity of the 17alpha-hydroxylation and lyase steps.

276 its crystal structure, the first fungal ADS lyase structure determined, shows a high degree of struc

277 e for the previously described carbon-sulfur lyase SUR1 in processing cysteine-isothiocyanate conjuga

278 monocots, PAL also displays tyrosine ammonia lyase (TAL) activity, leading to the formation of p-coum

279 om grasses can also possess tyrosine ammonia-lyase (TAL) activity, the reason for which has remained

280 erium expressed a single-surface endo-acting lyase that cleaved HS, reflecting its higher molecular w

281 ssion of YOR1 (exporter of PHS-1P) and DPL1 (lyase that degrades DHS-1P and PHS-1P) was increased.

282 action of pectin-methylesterase and pectate-lyase that possibly originated from a microbial source o

283 side hydrolases (GHs) and one polysaccharide lyase, the genes for which were transcribed at high leve

284 re unmasked by a pre-treatment with alginate lyases to remove alginates.

285 c, kinetic, or stability issues (isomerases, lyases, transglycosidases).

286 ionine beta-synthase and cystathionine gamma-lyase, two enzymes of the transsulfuration pathway, the

287 adaptions to low phosphate environments, C-P lyase was found to become more prevalent as phosphate co

288 The first characterized ulvan lyase was identified in Nonlabens ulvanivorans, an ulvan

289 C-P lyase was particularly enriched in the Mediterranean Sea

290 In these regions, C-P lyase was prevalent in several lineages of Alphaproteoba

291 genetic specificities of various periplasmic lyases which dictate glycosaminoglycan metabolic pathway

292 The degradation of ulvan requires ulvan lyase, which catalyzes the endolytic cleavage of the gly

293 radation of the enzyme phenylalanine ammonia-lyase, which catalyzes the first step of the phenylpropa

294 d TRIF resulted in activation of ATP-citrate lyase, which in turn facilitated the induction of distin

295 erase 1A and adenosine tri-phosphate citrate lyase, which, together, impart macrophages with antitumo

296 Alginate lyases, which are important in both basic and applied sc

297 otein lyase related to cyanobacterial T-type lyases, which facilitate attachment of linear tetrapyrro

298 Two cytosol ATP-citrate lyases, which take part in the cycle of citrate synthesi

299 It is possible that the bacterium recruits lyases with highly plastic specificities and expresses a

300 e periplasm were degraded by a repertoire of lyases, with each enzyme displaying specificity for subs