ライフサイエンスコーパス: lymph gland

1 edullary zone and the secondary lobes of the lymph gland.

2 veloping Drosophila hematopoietic organ, the lymph gland.

3 h expressing HSCs in the first instar larval lymph gland.

4 genitors and complete differentiation of the lymph gland.

5 found in the hematopoietic organ, called the lymph gland.

6 reduced, leading to a significantly smaller lymph gland.

7 genitors within the hematopoietic organ, the lymph gland.

8 t fills wide spaces scattered throughout the lymph gland.

9 hyperplasia of the hematopoietic organ, the lymph gland.

10 re (PSC), within the developing third-instar lymph gland.

11 sis occurs in a specialized organ called the lymph gland.

12 Serpent in hematopoietic progenitors in the lymph gland.

13 t of all cardiogenic mesoderm, including the lymph gland.

14 s and crystal cells in the Drosophila larval lymph gland.

15 essed in the nascent hemocytes of the larval lymph gland.

16 , blood cells or hemocytes are formed in the lymph gland.

17 Blood progenitors within the lymph gland, a larval organ that supports hematopoiesis

18 ate marks a discrete cluster of cells in the lymph gland, a signaling center, with functional similar

19 lwr function primarily in hemocytes and the lymph glands, a hematopoietic organ in Drosophila larvae

20 These lymph glands also contain pluripotent precursor cells th

21 In the lymph gland, an hematopoietic organ in Drosophila larva,

22 ling blood cell maturation in the developing lymph gland and exert their functions both in a cell-aut

23 yzed cis-regulation of ush expression in the lymph gland and identified similarities and differences

24 ARF1 is expressed in the larval lymph gland and in circulating hemocytes and interacts w

25 he number of hematopoietic precursors in the lymph gland and of mature blood cells in circulation, an

26 aligned cardioblasts and the absence of most lymph gland and pericardial cells.

27 Conversely, a significant expansion of the lymph glands and abnormal morphology of the heart were o

28 sed in the immune system (type A; hemocytes, lymph glands and fat body) and genes increased in expres

29 heterogeneity of developing hemocytes in the lymph gland, and discover previously undescribed hemocyt

30 e injury has on the hematopoietic organ, the lymph gland, and the circulating blood cells in the larv

31 , which is strongly expressed in the gut and lymph glands, and ADGF-D, which is mainly expressed in t

32 or such mutations have small imaginal discs, lymph glands, and brain lobes.

33 d typed M. microti bacteria in skin lesions, lymph glands, and internal abcesses.

34 mutant embryos, but in a large fraction the lymph glands are missing.

35 hematopoietic progenitor maintenance in the lymph gland blood cell-forming organ during Drosophila h

36 To identify new genes involved in lymph gland blood progenitor maintenance, particularly t

37 g the downstream Hippo pathway kinase Warts, lymph gland cells overproliferated, differentiated prema

38 developing embryonic dorsal vessel (heart), lymph glands, circular visceral musculature, and a subse

39 failure of larval hemocyte proliferation and lymph gland development, while Dm-Myb(-/-) hemocytes fro

40 vel population of signaling cells within the lymph gland, distinct from the PSC, that are required fo

41 We analyzed PSC cell number in lymph glands double-mutant for bam and InR pathway genes

42 turation, signaling and proliferation in the lymph gland during hematopoietic progression are describ

43 on factor in dorsal vessel morphogenesis and lymph gland formation and place this regulator directly

44 verting it into a repressor blocks heart and lymph gland formation.

45 dFKBP59 expression in specific tissues: the lymph glands, Garland cells and oenocyte cells, which ar

46 genitors, or prohemocytes, within the larval lymph gland gives rise to three mature cell types: plasm

47 Mechanistic studies of Drosophila lymph gland hematopoiesis are limited by the availabilit

48 ling by ROS levels in the PSC/niche controls lymph gland hematopoiesis under parasitism.

49 During lymph gland hematopoiesis, the Drosophila posterior sign

50 ulatory strategies used during embryonic and lymph gland hematopoiesis.

51 ocardium and a deficiency of pericardial and lymph gland hematopoietic cells, accompanied by cardiac

52 s of the heart tube as well as in associated lymph gland hematopoietic organs and alary muscles that

53 m: cardioblasts, pericardial nephrocytes and lymph gland hematopoietic progenitors, but its function

54 at both cell division and differentiation of lymph gland hemocytes are required for encapsulation.

55 id cells, yet molecular underpinnings of the lymph gland hemocytes have been less investigated.

56 shaped (Ush) is expressed in circulating and lymph gland hemocytes, where it plays a critical role in

57 es between embryonically derived- and larval lymph gland hemocytes.

58 lar system acts as a second niche to control lymph gland homeostasis.

59 These include lymph gland hypertrophy, increased circulating hemocyte

60 parasitism non-cell autonomously induces the lymph gland immune response.

61 The Drosophila melanogaster lymph gland is a haematopoietic organ in which pluripote

62 The Drosophila melanogaster lymph gland is a hematopoietic organ and, together with

63 The lymph gland is a specialized organ for hematopoiesis, ut

64 The Drosophila larval lymph gland is a well-studied model to understand blood

65 The Drosophila hematopoietic lymph gland is located along the cardiac tube which corr

66 The lymph gland is the major site of hematopoiesis in Drosop

67 , postinfection mitotic amplification in the lymph glands is absent and there is a reduction in cryst

68 melanogaster larval hematopoietic organ, the lymph gland, is a model to study in vivo the function of

69 gating of live Drosophila hemocytes from the lymph glands (larval hematopoietic organ) or hemolymph (

70 The lymph gland (LG) is a major source of hematopoiesis duri

71 We demonstrate that in the Drosophila lymph gland (LG) the tumor suppressors TSC and PTEN cont

72 specialized larval hematopoietic organ, the lymph gland (LG), within which stem-like hemocyte precur

73 he controls hematopoietic progenitors of the lymph gland (LG).

74 ursor hemocytes: mutant larvae have enlarged lymph glands (LGs) and have an excess of circulating hem

75 n with a loss of the majority of the primary lymph gland lobes.

76 w that the hematopoietic niche of the larval lymph gland of Drosophila senses immune challenge and re

77 Consistent with this, the phenotype of the lymph gland of Zfpr8 heterozygous mutants is dominantly

78 In addition, the lymph glands of cactus larvae are considerably enlarged.

79 fide hematopoietic stem cells (HSCs) in the lymph glands of embryos and young larvae, which give ris

80 is highly overexpressed in the hemocytes and lymph glands of third instar larvae carrying the dominan

81 These changes, observed in the lymph glands of third-instar, but never of second-instar

82 on of wild-type Cactus protein in the larval lymph gland or by the introduction of mutations in Toll,

83 with one site proven to be essential for the lymph gland, pericardial cell, and Svp/Doc cardioblast e

84 bitor P35, partially rescued the cardiac and lymph gland phenotypes.

85 ure hemocytes have been characterized in the lymph gland: plasmatocytes, lamellocytes, and crystal ce

86 trate a key function for Bam in cells of the lymph gland posterior signaling center (PSC), a cellular

87 microRNA-7 (mir-7) mutant lymph glands present with phenotypes identical to those

88 sion of the GATA factor Serpent (Srp) in the lymph-gland primordium.

89 In Drosophila melanogaster, the lymph gland produces plasmatocytes and crystal cells tha

90 rotein U-shaped is an important regulator of lymph gland prohemocyte potency and differentiation.

91 determined to be upregulated in third-instar lymph gland prohemocytes and downregulated in a subpopul

92 The overproliferation of cells in the lymph gland results in abnormal hemocyte differentiation

93 Conversely, forced expression of Bam in the lymph gland results in expansion of prohemocytes and sub

94 By contrast, analysis of yan mutant lymph glands revealed that this transcriptional regulato

95 ARF1-depleted lymph glands show loss of niche cells and prohemocyte ma

96 manipulation of yorkie and scalloped in the lymph gland specifically alters Serrate expression and c

97 In this systematic analysis of lymph gland structure and gene expression, we define the

98 caused a milder phenotype that preserved the lymph gland structure but that included precocious diffe

99 Atg6 mutants have enlarged lymph glands (the hematopoietic organ in Drosophila), po

100 In the normal lymph gland, the ECM forms thin basement membranes aroun

101 The Drosophila lymph gland, the larval hematopoietic organ comprised of

102 In the lymph gland, the niche called Posterior Signaling Center

103 In the Drosophila hematopoietic organ, the lymph gland, the posterior signaling center (PSC) acts a

104 A small cluster of cells in the lymph gland, the posterior signaling center (PSC), maint

105 The Drosophila lymph gland, the source of adult hemocytes, is establish

106 trate that Bam has a crucial function in the lymph gland, the tissue that orchestrates the second pha

107 ineage-specifying cells is eliminated in the lymph gland upon the immune response induced by wasp par

108 Using Drosophila hematopoietic organ: lymph gland, we demonstrate that Fatty Acid Oxidation (F

109 sing the Drosophila hematopoietic organ, the lymph gland, we show that cells of the hematopoietic nic

110 om clonal loss and over-expression of pnr in lymph glands, we find that Pnr is positively regulated b

111 the break-down of the usual zonation of the lymph gland. which normally consists of an immature cent

112 d in the hemocoel or in association with the lymph gland, while melanizations are located in the gut,

113 stem cells (HSCs) in Drosophila, the larval lymph gland with its Hedgehog dependent progenitors serv