ライフサイエンスコーパス: lymphatic endothelial cell

1 ular endothelial growth factor-A, and D2-40 (lymphatic endothelial cells).

2 atic vessels in mice and in human intestinal lymphatic endothelial cells.

3 ell identity, in Tie2 lineage venous-derived lymphatic endothelial cells.

4 ammatory responses in cardiac and peripheral lymphatic endothelial cells.

5 the expression of JAM-B on murine and human lymphatic endothelial cells.

6 proliferation in primary human blood versus lymphatic endothelial cells.

7 has proliferative and chemotactic effects on lymphatic endothelial cells.

8 oted by glucocorticoid receptor signaling in lymphatic endothelial cells.

9 s) to enhance the lymphangiogenic ability of lymphatic endothelial cells.

10 g glucocorticoid receptor phosphorylation in lymphatic endothelial cells.

11 EGFR3), the major growth factor receptor for lymphatic endothelial cells.

12 olymphangiogenic VEGF-D and proliferation of lymphatic endothelial cells.

13 ion, invasion, and survival of proliferating lymphatic endothelial cells.

14 cells; on further cultivation, they generate lymphatic endothelial cells.

15 dentified expression of several connexins in lymphatic endothelial cells.

16 and tube formation in cocultured vascular or lymphatic endothelial cells.

17 leading to increased receptor expression in lymphatic endothelial cells.

18 imulation that resulted from cross talk with lymphatic endothelial cells.

19 ed Notch receptors in contrast to uninfected lymphatic endothelial cells.

20 with KSHV and has markers of both blood and lymphatic endothelial cells.

21 verexpressing tumors contained proliferating lymphatic endothelial cells.

22 ylation, and induced mitogenesis in vitro of lymphatic endothelial cells.

23 ply of fibroblast growth factors (FGFs) from lymphatic endothelial cells.

24 maintained in the lung by IL-7, produced by lymphatic endothelial cells.

25 paracrine activation of the mTOR pathway in lymphatic endothelial cells.

26 tone for the differentiation and function of lymphatic endothelial cells.

27 hages, because IL-10 did not directly affect lymphatic endothelial cells.

28 transmembrane ligand podoplanin expressed by lymphatic endothelial cells.

29 te chemotactic migration of EMT cells toward lymphatic endothelial cells.

30 s pathological changes in gene expression in lymphatic endothelial cells.

31 hand, TGF-beta1 promoted CCL21 expression in lymphatic endothelial cells.

32 d changes in the gene expression patterns of lymphatic endothelial cells.

33 1-mediated crosstalk between tumor cells and lymphatic endothelial cells.

34 In human dermal lymphatic endothelial cells, activation of Notch1 or Not

35 odel of lymphatic uptake, we have shown that lymphatic endothelial cells actively enhanced lymphatic

36 TNFR1 signalling pathway directly stimulates lymphatic endothelial cell activity through a VEGFR3-ind

37 n of T1alpha/podoplanin expression decreased lymphatic endothelial cell adhesion.

38 After AKI, renal lymphatic endothelial cells alter genes involved in endo

39 difying protein 2/3, are highly expressed in lymphatic endothelial cells and are required for embryon

40 subcapsular sinus or medulla, near or within lymphatic endothelial cells and CD169(+) macrophages.

41 TSC2 correction, AML cells mature into adult lymphatic endothelial cells and have functional attribut

42 gers phosphorylation of cell surface TLR3 on lymphatic endothelial cells and induces apoptosis.

43 ferentiation of blood endothelial cells into lymphatic endothelial cells and may be relevant to the d

44 the expression pattern of the Prox1 gene in lymphatic endothelial cells and other Prox1-expressing o

45 platelet-derived growth factor B (PDGF-B) in lymphatic endothelial cells and signaling through platel

46 ed that the VEGFC/VEGFR3 axis can shape both lymphatic endothelial cells and TAMs to synergistically

47 VEGF receptor-3 stimulation activate eNOS in lymphatic endothelial cells and that NO donors induce pr

48 nd Notch4 were expressed in normal and tumor lymphatic endothelial cells and that Notch1 was activate

49 ed, but little is known about the biology of lymphatic endothelial cells and the molecular mechanisms

50 rtially remodeled blood vessels incorporated lymphatic endothelial cells and were permeable to blood.

51 ial cells from this niche differentiate into lymphatic endothelial cells and, in close association wi

52 ubsets, namely fibroblastic reticular cells, lymphatic endothelial cells, and blood endothelial cells

53 galectin-1 is also highly expressed by human lymphatic endothelial cells, and deposition of galectin-

54 le to promote increased COX-2 mRNA levels in lymphatic endothelial cells, and had enhanced capacity t

55 These results establish lymphatic endothelial cells, and potentially other LN-re

56 al microvascular endothelial cells, isolated lymphatic endothelial cells, and purified vascular endot

57 Our data provide evidence that lymphatic endothelial cells are an in vivo source of S1P

58 of Immunity, Mondor et al. (2019) show that lymphatic endothelial cells are essential components of

59 SC subsets, fibroblastic reticular cells and lymphatic endothelial cells are known to directly induce

60 Most studies have suggested that lymphatic endothelial cells are the main vehicles for D6

61 es express all of the molecular hallmarks of lymphatic endothelial cells, are able to carry both flui

62 lopmental or pathological differentiation of lymphatic endothelial cells as well as to KSHV pathogene

63 non-neoplastic human primary cell line (lung lymphatic endothelial cells) as a typical normal host ce

64 promotes platelet adhesion to primary mouse lymphatic endothelial cells at low shear.

65 of the disease, with active proliferation of lymphatic endothelial cells at the early stages of lymph

66 Platelets are activated by interaction with lymphatic endothelial cells at the lymphovenous junction

67 Apart from the mutations that act as lymphatic endothelial cell-autonomous drivers of these a

68 om E9.75 to E13.5, resulting in misspecified lymphatic endothelial cells based upon reduced expressio

69 matched donor-derived human dermal blood and lymphatic endothelial cells (BEC and LEC, respectively)

70 at platelet CLEC-2 and Syk directly modulate lymphatic endothelial cell behavior in vitro.

71 These brain lymphatic endothelial cells (BLECs) derive from venous e

72 ific lymphatics, the cellular origin of bone lymphatic endothelial cells (bLECs) is not known and the

73 rmal tissues, including kidney podocytes and lymphatic endothelial cells but not vascular endothelial

74 on is strongly downregulated in normal adult lymphatic endothelial cells, but is activated in patholo

75 through the extracellular matrix and across lymphatic endothelial cells, but it has no effect on mig

76 n, migration, and tube formation of cultured lymphatic endothelial cells by activating fibroblast gro

77 We identified a heterogenous population of lymphatic endothelial cell clusters in mouse and human e

78 ypes indicated recruitment and activation of lymphatic endothelial cells.Conclusions: A unique popula

79 Similarly, blood and lymphatic endothelial cells contribute to tissue homeost

80 Additionally, a human lymphatic endothelial cell culture system was used to ex

81 lates cytoskeletal and membrane structure of lymphatic endothelial cells; dependent on VCAM-1 and non

82 Lymphatic endothelial cell-derived S1P was not required.

83 During development, lymphatic endothelial cells differentiate from preexisti

84 infection of blood endothelial cells induces lymphatic endothelial cell differentiation.

85 receptors, Unc5B and neogenin, expressed by lymphatic endothelial cells, do not suppress netrin-4-in

86 orphogenesis was studied using a conditional lymphatic endothelial cell driver either to delete Notch

87 nic cytokines and increased proliferation of lymphatic endothelial cells during coculture, suggesting

88 calization in the luminal plasma membrane of lymphatic endothelial cells during later development.

89 lk and single-cell RNA sequencing of the non-lymphatic endothelial cells (ECs) of the kidney to ident

90 In vitro, VEGF-C/VEGFR3 signalling in lymphatic endothelial cells enhances inflammatory respon

91 w did not alter vessel identity in vivo, but lymphatic endothelial cells exposed to similar levels of

92 Lymphatic endothelial cells express key components of th

93 We demonstrate that LN-resident lymphatic endothelial cells express multiple peripheral

94 inantly keratinocytes and a subset of dermal lymphatic endothelial cells, express ACKR4 and are capab

95 We also propose that lymphatic endothelial cell-expressed D6 might have a dis

96 SEMA3F were chemorepulsive for vascular and lymphatic endothelial cells expressing neuropilin-2 (NRP

97 d lymphangiogenesis, lymphatic function, and lymphatic endothelial cell expression of chemokine (C-C

98 known regulator of lymphatic development and lymphatic endothelial cell fate, as a direct interacting

99 Arteriovenous-lymphatic endothelial cell fates are specified by the ma

100 Lymphatic endothelial cells, for example, directly prese

101 In cultured lymphatic endothelial cells, FOXC2 inactivation conferre

102 d Foxc mutants show a defect in sprouting of lymphatic endothelial cells from veins in early lymphati

103 xamine the effect of VLA-1 gene depletion on lymphatic endothelial cell functions in vitro using smal

104 dition, our study shows that obesity-induced lymphatic endothelial cell gene expression changes are r

105 In addition, exercise normalized isolated lymphatic endothelial cell gene expression of lymphatic

106 l zone and that the S1P transporter SPNS2 on lymphatic endothelial cells generated this gradient.

107 HA and HS and altered expression of CD44 and lymphatic endothelial cell HA receptor-1, HA receptors o

108 Whether lymphatic endothelial cells have a single or dual, venou

109 and few molecules that are truly specific to lymphatic endothelial cells have been identified to date

110 Alternative nonvenous sources of lymphatic endothelial cells have been suggested in chick

111 we studied PD-L1 expression in human dermal lymphatic endothelial cells (HDLECs), which play key rol

112 of this interaction in primary human dermal lymphatic endothelial cells (HDLECs).

113 doplanin(+) cells highly express markers for lymphatic endothelial cells, hematopoietic lineages, and

114 Primary human lymphatic endothelial cells (HLECs) lacking GATA2 (HLEC(

115 sferred by CSCC-secreted exosomes into human lymphatic endothelial cells (HLECs) to promote HLECs mig

116 In vitro experiments in cultured human lymphatic endothelial cells identified a novel mechanism

117 transcription factor, a master regulator of lymphatic endothelial cell identity, in Tie2 lineage ven

118 Soluble LYVE-1 and knockdown of LYVE-1 in lymphatic endothelial cells impaired FGF2 signaling and

119 P-2 is involved in the outgrowth of cultured lymphatic endothelial cells in a collagen matrix in vitr

120 ce proliferation and/or survival of cultured lymphatic endothelial cells in a dose-dependent manner.

121 or using inducible lung-specific ablation of lymphatic endothelial cells in a lung transplant model r

122 This first report on brain lymphatic endothelial cells in a vertebrate embryo ident

123 d, CXCL12, is expressed by cells adjacent to lymphatic endothelial cells in a zone that abuts but min

124 significantly decreased the proliferation of lymphatic endothelial cells in culture and the number of

125 Recent studies of brain meningeal lymphatic endothelial cells in mouse and zebrafish have

126 , and one of the most widely used markers of lymphatic endothelial cells in normal and tumor tissues.

127 we investigated the development of blood and lymphatic endothelial cells in prenatal human skin in si

128 inhibited KSHV infection of blood vessel and lymphatic endothelial cells in the micromolar concentrat

129 a nor progesterone receptor were detected in lymphatic endothelial cells in the mouse mammary gland,

130 dependent vesicular transcytosis through the lymphatic endothelial cells in the subcapsular sinus of

131 Lymphatic endothelial cells in turn responded to Reelin

132 hesion, tube formation and survival of human lymphatic endothelial cells in vitro comparable to well-

133 atelet aggregate formation on the surface of lymphatic endothelial cells in vivo and ex vivo.

134 FOXC1 knockdown (KD) in human lymphatic endothelial cells increased focal adhesions an

135 IP-Tag2 mice upregulates c-Met expression in lymphatic endothelial cells, increases the number of int

136 Incubation with supernatant from lymphatic endothelial cells induced an endothelium-like

137 r 2 (CLEC-2) on platelets with Podoplanin on lymphatic endothelial cells initiates platelet signaling

138 ar level, we showed that FGFR-1 expressed in lymphatic endothelial cells is a crucial receptor that m

139 endothelial nitric oxide synthase (eNOS) in lymphatic endothelial cells is required for robust lymph

140 heptahelical membrane protein, expressed by lymphatic endothelial cells, is able to bind with high a

141 membrane protein expressed on the surface of lymphatic endothelial cells, is required in nonhematopoi

142 Lymphatic endothelial cells lack the Ca(2+) -activated K

143 Non-mutually-exclusive mechanisms are lymphatic endothelial cell (LEC) chemotaxis and prolifer

144 Previous studies show that lymphatic endothelial cell (LEC) fate is highly plastic

145 blood endothelial cells (BECs) to acquire a lymphatic endothelial cell (LEC) fate.

146 opment of the lymphatic system by specifying lymphatic endothelial cell (LEC) fate.

147 function, but required for stabilization of lymphatic endothelial cell (LEC) junctions in different

148 Lymphatic endothelial cell (LEC) junctions in initial ly

149 Our data show that lymphatic endothelial cell (LEC) migration through colla

150 at excess VEGF-C did not enhance the rate of lymphatic endothelial cell (LEC) migration, the density

151 Ang-4 decreased human dermal lymphatic endothelial cell (LEC) monolayer permeability

152 at Tbx1 is activated and required in cardiac lymphatic endothelial cell (LEC) progenitors between E10

153 f lymphangiogenesis in Prox1-positive venous lymphatic endothelial cell (LEC) progenitors.

154 potent lymphangiogenic factor that promotes lymphatic endothelial cell (LEC) proliferation through a

155 Thus, Kaposi sarcoma tumors express numerous lymphatic endothelial cell (LEC) signature genes.

156 VEGFR-3 does not affect galectin-8-mediated lymphatic endothelial cell (LEC) sprouting.

157 KS spindle cells are believed to be of the lymphatic endothelial cell (LEC) type.

158 CCL21, a lymphatic endothelial cell (LEC)-derived chemokine, and

159 Lymphatic endothelial cell (LEC)-specific deletion of Il

160 okine-scavenging receptor D6 is expressed on lymphatic endothelial cells (LEC) and contributes to sel

161 We previously identified lymphatic endothelial cells (LEC) as the repository for

162 h neuropilin-2 (NRP2) is highly expressed in lymphatic endothelial cells (LEC) but not in oral epithe

163 induces the collapse of the cytoskeleton of lymphatic endothelial cells (LEC) in a neuropilin-2-, pl

164 Though lymphatic endothelial cells (LEC) lining the LV express

165 The migration of lymphatic endothelial cells (LEC) toward guidance cues i

166 us cell types across primary mouse and human lymphatic endothelial cells (LEC), and validated the mod

167 ane glycoprotein expressed on the surface of lymphatic endothelial cells (LEC).

168 ) infection and is thought to originate from lymphatic endothelial cells (LEC).

169 We isolated lymphatic endothelial cells (LECs) and blood vascular en

170 nregulate essential transcription factors of lymphatic endothelial cells (LECs) and inhibit tube form

171 hyaluronan receptor 1 (LYVE1), which include lymphatic endothelial cells (LECs) and liver sinusoidal

172 nstrated generation of purified hPSC-derived lymphatic endothelial cells (LECs) and tested their ther

173 lls of Kaposi sarcoma are closely related to lymphatic endothelial cells (LECs) and that Kaposi sarco

174 a consequence of increased proliferation of lymphatic endothelial cells (LECs) and was also observed

175 We show here that lymphatic endothelial cells (LECs) are a prominent sourc

176 ystem, and there is growing recognition that lymphatic endothelial cells (LECs) are involved in immun

177 Lymphatic endothelial cells (LECs) are known to produce

178 Fibroblastic reticular cells (FRCs) and lymphatic endothelial cells (LECs) are nonhematopoietic

179 In the absence of Prox1, lymphatic endothelial cells (LECs) are not specified.

180 Lymphatic endothelial cells (LECs) are the building bloc

181 Recent studies have identified lymphatic endothelial cells (LECs) as a major source of

182 We show that abnormal flow sensing in lymphatic endothelial cells (LECs) caused by Sdc4 or Pec

183 Lymphatic endothelial cells (LECs) chemoattract naive T

184 In this five-stage protocol, human lymphatic endothelial cells (LECs) cocultured with derma

185 w that a lymphoangiocrine signal produced by lymphatic endothelial cells (LECs) controls the prolifer

186 Lymphatic endothelial cells (LECs) directly express peri

187 Dermal lymphatic endothelial cells (LECs) emerge from the dorso

188 We tested the hypothesis that lymphatic endothelial cells (LECs) exhibit Ca(2+) and el

189 In vitro cultured mouse lymphatic endothelial cells (LECs) expressed VitD Recept

190 othelial cells (BECs) with the properties of lymphatic endothelial cells (LECs) has been identified i

191 ranscriptional profiling of ex vivo isolated lymphatic endothelial cells (LECs) identified 160 genes

192 Here, we report the profiling of 33,000 lymphatic endothelial cells (LECs) in human lymph nodes

193 Until recently, the known roles of lymphatic endothelial cells (LECs) in immune modulation

194 Tumor cell migration to lymphatic endothelial cells (LECs) in vitro is inhibited

195 Lymphatic endothelial cells (LECs) induce peripheral tol

196 established a new infection model of primary lymphatic endothelial cells (LECs) infected with a lytic

197 Transendothelial transport across lymphatic endothelial cells (LECs) is commonly considere

198 In this study, we demonstrate that lymphatic endothelial cells (LECs) modulate the maturati

199 However, whether LPA exerts an effect on lymphatic endothelial cells (LECs) or on lymphangiogenes

200 In vitro evaluation of lymphatic endothelial cells (LECs) revealed that low, re

201 In particular, KSHV-infected lymphatic endothelial cells (LECs) show an up-regulation

202 ut stimuli in the context of the response of lymphatic endothelial cells (LECs) to fluid flow.

203 Breast cancer cells 'educate' lymphatic endothelial cells (LECs) to support tumor vasc

204 Antigen is captured by lymphatic endothelial cells (LECs) under conditions that

205 Lymphatic endothelial cells (LECs) were the main source

206 These Prox1-expressing lymphatic endothelial cells (LECs) will exit the CV to f

207 that they are formed by the intercalation of lymphatic endothelial cells (LECs) with a subpopulation

208 Here we show that lymphatic endothelial cells (LECs), a component of LVs w

209 sarcoma-associated herpesvirus infection of lymphatic endothelial cells (LECs), but not blood endoth

210 upregulates mTOR signaling in primary human lymphatic endothelial cells (LECs), but not blood endoth

211 on, and morphologic differentiation of human lymphatic endothelial cells (LECs), consistent with an i

212 atory cytokines trigger activation of dermal lymphatic endothelial cells (LECs), leading to expressio

213 ess responses in blood endothelial cells and lymphatic endothelial cells (LECs), only LECs display re

214 which induced migration and proliferation of lymphatic endothelial cells (LECs), processes required f

215 o CPX inhibitory effect on tube formation in lymphatic endothelial cells (LECs), whereas downregulati

216 smorphogenesis of vascular channels lined by lymphatic endothelial cells (LECs).

217 activity results in the complete absence of lymphatic endothelial cells (LECs).

218 immune responses has included a new focus on lymphatic endothelial cells (LECs).

219 receptor that is expressed on both blood and lymphatic endothelial cells (LECs).

220 ulated by molecular interactions mediated by lymphatic endothelial cells (LECs).

221 cognate receptor VEGF receptor-3 (VEGFR3) in lymphatic endothelial cells (LECs).

222 lymphatic vasculature: the specification of lymphatic endothelial cells (LECs).

223 r Prox1 functions to reprogram venous ECs to lymphatic endothelial cells (LECs).

224 si sarcoma (KS), a tumor genetically akin to lymphatic endothelial cells (LECs).

225 expression of the VEGF-C receptor VEGFR3 in lymphatic endothelial cells (LECs).

226 2 expression) and human dermal microvascular lymphatic endothelial cells (LECs).

227 eduction of HIF-2alpha protein expression in lymphatic endothelial cells (LECs).

228 essels (blood vascular endothelial cells and lymphatic endothelial cells [LECs]) were exposed to low-

229 Moreover, genetic inactivation of Dll4 in lymphatic endothelial cells led to lacteal regression an

230 Under these conditions, lymphatic endothelial cells, like tumor cells, had stron

231 he trans-differentiation of macrophages into lymphatic endothelial cell-like structures in culture.

232 A recently established immortalised lymphatic endothelial cell line (imLEC) could become a p

233 Lymphatic endothelial cells lining the ceiling of the su

234 ACKR4-mediated CCL21 scavenging by lymphatic endothelial cells lining the subcapsular sinus

235 ls, but did not affect MT1-MMP expression in lymphatic endothelial cells, LVI, or lymph node metastas

236 These cells also express another lymphatic endothelial cell marker, Flt4/VEGFR3, but not

237 Here, we demonstrated the expression of lymphatic endothelial cell markers by the SC in murine a

238 We found that AML cells express lymphatic endothelial cell markers consistent with lymph

239 lacked luminal valves and expression of the lymphatic endothelial cell markers podoplanin and lympha

240 lial growth factor resulted in expression of lymphatic endothelial cell markers.

241 DV infects human pulmonary microvascular and lymphatic endothelial cells (MECs and LECs, respectively

242 ons in breast cancer, it remains unclear how lymphatic endothelial cell metabolism is altered in the

243 sponse, while in vitro, the cells stimulated lymphatic endothelial cell migration via the actions of

244 uely correlating interstitial fluid flow and lymphatic endothelial cell migration with lymphatic func

245 ated receptor kinase signaling and blood and lymphatic endothelial cells migration and proliferation.

246 cteristic of this cell lineage, suggesting a lymphatic endothelial cell of origin for AML.

247 Further, inactivation of Ephb4 in lymphatic endothelial cells of developing mouse embryos

248 Our results show lymphatic endothelial cells of the thoracic duct arise f

249 ome enriched and differentially expressed by lymphatic endothelial cells on the upstream and downstre

250 (1) interstitial fluid channels form before lymphatic endothelial cell organization and (2) lymphati

251 In development, lymphatic endothelial cells originate within veins and d

252 blood endothelial cells reprograms them to a lymphatic endothelial cell phenotype.

253 ed into the lymphatic vasculature, displayed lymphatic endothelial cell phenotypes, and increased lym

254 phenotype that is a blend of both blood and lymphatic endothelial cell phenotypes.

255 tic endothelial cell markers consistent with lymphatic endothelial cell precursors in vivo and in vit

256 gene depletion led to a marked inhibition of lymphatic endothelial cell processes of adhesion, prolif

257 Demonstration of a previously unknown lymphatic endothelial cell progenitor population will no

258 esis is strongly promoted by myeloid-derived lymphatic endothelial cell progenitors (M-LECPs) derived

259 n rats subjected to focal cerebral ischemia, lymphatic endothelial cells proliferate and macrophages

260 Infiltrating lymphatic endothelial cells proliferated, aggregated, an

261 GFR-2 during infection led to a reduction in lymphatic endothelial cell proliferation and simultaneou

262 etion of CLEC-2 induced a profound defect in lymphatic endothelial cell proliferation, resulting in l

263 ugular lymphatic vessels due to reduction in lymphatic endothelial cell proliferation.

264 bitor inhibited the proliferation of primary lymphatic endothelial cells promoted by mammary gland co

265 FOXC2 and oscillatory shear stress maintain lymphatic endothelial cell quiescence through intercellu

266 change in vessel identity was the result of lymphatic endothelial cell reprogramming rather than rep

267 transcripts and protein in keratinocytes and lymphatic endothelial cells, respectively.

268 ptor that activates platelets in response to lymphatic endothelial cells, resulted in backfilling of

269 ted Prox1 and VEGFR-3 expression in cultured lymphatic endothelial cells, resulting in increased prol

270 Normally, VEGFR-3 activates Akt signaling in lymphatic endothelial cells, resulting in lymphangiogene

271 Studies in cultured lymphatic endothelial cells revealed that VEGF-A induced

272 KSHV-infected lymphatic endothelial cells showed induction of receptor

273 In mice, lymphatic endothelial cell-specific (LEC-specific) delet

274 The induction of the lymphatic endothelial cell-specific transcription factor

275 red for KSHV-induced expression of VEGFR3, a lymphatic endothelial-cell-specific receptor important f

276 ermined that from venous-derived lymph sacs, lymphatic endothelial cells sprouted, proliferated, and

277 transgenic mouse models, we demonstrate that lymphatic endothelial cells support the survival of T ce

278 r KSHV genome maintenance and lytic cycle in lymphatic endothelial cells, supporting Kaposi sarcoma t

279 s Unc5B and neogenin, are expressed by human lymphatic endothelial cells, suppression of either or bo

280 umor-associated macrophages, as well as more lymphatic endothelial cells than tumors from PyMT mice.

281 el role for Notch1 in limiting the number of lymphatic endothelial cells that differentiate from the

282 ically, we demonstrate that in primary human lymphatic endothelial cells, the integrin-alpha9-EIIIA i

283 the recent isolation of pure populations of lymphatic endothelial cells, the investigation of lympha

284 the migration and intercellular adhesion of lymphatic endothelial cells through a pathway that depen

285 lar development by directly interacting with lymphatic endothelial cells through C-type lectin-like r

286 Thus, the VEGFR-3-induced lymphatic endothelial cell tip cell formation is a prere

287 However, VEGFR3-induced lymphatic endothelial cell tips are a prerequisite for l

288 We used human lymphatic endothelial cells to establish a reliable thre

289 gene expression profiles of ex vivo isolated lymphatic endothelial cells to identify novel lymphatic

290 1 signaling regulates the differentiation of lymphatic endothelial cells to influence the lymphatic v

291 loid origin and distinguish them from mature lymphatic endothelial cells, tumor-infiltrating lymphoid

292 the production of the main growth factor for lymphatic endothelial cells, VEGFC.

293 The peptide inhibits blood and lymphatic endothelial cell viability, migration, adhesio

294 chemical analyses of the receptor in primary lymphatic endothelial cells, we provide the first eviden

295 because critical specific characteristics of lymphatic endothelial cells were discovered only recentl

296 vascular smooth muscle cells, and VEGFR3 in lymphatic endothelial cells were essential for their dev

297 primary arterial, venous, microvascular, and lymphatic endothelial cells were performed using PBS.

298 Gp38) is highly expressed on the surface of lymphatic endothelial cells, where it regulates developm

299 y, Prox1 expression is high in valve-forming lymphatic endothelial cells, whereas cells of the lympha

300 Lymphatic endothelial cells, which experience much lower