ライフサイエンスコーパス: lymphatic system

1 cations in noninvasive 3D imaging (e.g., the lymphatic system).

2 tumor and travel through the bloodstream and lymphatic system.

3 pment, to maintaining integrity of the adult lymphatic system.

4 iatic nerve and in the regional and systemic lymphatic system.

5 process is largely taking place through the lymphatic system.

6 quences of diet induced obesity (DIO) on the lymphatic system.

7 o be at least partially mediated through the lymphatic system.

8 ported from the lumena of the lungs into the lymphatic system.

9 se or micrometastases, especially within the lymphatic system.

10 djacent to the CD45(+) lymphoid cells of the lymphatic system.

11 oiting NO signaling to treat diseases of the lymphatic system.

12 the parachordal vessel, the precursor to the lymphatic system.

13 their different abilities to survive in the lymphatic system.

14 al. report that HSCs also travel through the lymphatic system.

15 pulation, and passage through the venous and lymphatic system.

16 ic pressure (P(c)) and fluid efflux into the lymphatic system.

17 Metastases are commonly found in the lymphatic system.

18 on the development of the blood vascular and lymphatic system.

19 iding constitutive NF-kappaB activity in the lymphatic system.

20 re currently available to visualize the deep lymphatic system.

21 f these cells between spleen, blood, and the lymphatic system.

22 re needed to fulfill the unique roles of the lymphatic system.

23 ding from veins, gives rise to the mammalian lymphatic system.

24 al lymph nodes through the brain's primitive lymphatic system.

25 at by budding and sprouting give rise to the lymphatic system.

26 rs in the colon, mammary gland, and possibly lymphatic system.

27 fore their ultimate drainage to the systemic lymphatic system.

28 ion, and insufficient fluid clearance by the lymphatic system.

29 ferent potential approaches to accessing the lymphatic system.

30 of TIE1 is essential for its function in the lymphatic system.

31 understand the role of S1P receptors in the lymphatic system.

32 leading to reduced CM transport through the lymphatic system.

33 nt of new therapeutic agents that target the lymphatic system.

34 homa (HL) is a rare malignancy affecting the lymphatic system.

35 downstream effector of TIE1 signaling in the lymphatic system.

36 ells and its similar function to that of the lymphatic system.

37 s that are disconnected from the rest of the lymphatic system.

38 transporting these via the lymph across the lymphatic system.

39 brospinal fluid drains through the meningeal lymphatic system.

40 ssociated lymph nodes and gain access to the lymphatic system.

41 sinuses, required for a functional meningeal lymphatic system.

42 illary permeability and lack of a functional lymphatic system.

43 macrofilariae) in the complex anatomy of the lymphatic system.

44 ing sustained presentation of antigen to the lymphatic system.

45 control in chronic SCI also affects the skin lymphatic system.

46 the tissues is performed exclusively by the lymphatic system.

47 ter the blood circulation via the mesenteric lymphatic system.

48 vascular system, gastrointestinal tract, and lymphatic system.

49 iagnostic, and therapeutic approaches to the lymphatic system.

50 ological evidence of valves in the zebrafish lymphatic system.

51 h possibility of the SLNs to be taken by the lymphatic system.

52 size of HIV reservoirs within the mesenteric lymphatic system.

53 velopmental and/or functional defects in the lymphatic system.

54 thrombi that prevent blood from entering the lymphatic system.

55 for targeted, DC-like migration through the lymphatic system.

56 accumulates as a result of disruption of the lymphatic system.

57 rises both the cardiovascular system and the lymphatic system.

58 ot achieve therapeutic concentrations in the lymphatic system.

59 discover a novel role of this channel in the lymphatic system.

60 al vessel formation in both the vascular and lymphatic systems.

61 via misconnected portal vein and intestinal lymphatic systems.

62 ith death from tumors of the hemopoietic and lymphatic systems.

63 evated risk of tumors of the hemopoietic and lymphatic systems.

64 er injection into the general circulation or lymphatic systems.

65 an important interface between the blood and lymphatic systems.

66 r the normal performance of the vascular and lymphatic systems.

67 etic, parasympathetic, sensory and meningeal lymphatic systems.

68 diverse functions in the cardiovascular and lymphatic systems.

69 ues, (3) the flux of lymphocytes through the lymphatic system, (4) the number of lymph nodes, (5) the

70 rivileged access to immune cells through the lymphatic system, a tissue location that is inaccessible

71 secondary lymphoid tissue via the blood and lymphatic systems, a process that maximizes the chances

72 studied, but we propose that the glymphatic/lymphatic system acts as a cornerstone in signaling betw

73 nomodulator, mycophenolic acid (MPA), to the lymphatic system after oral administration.

74 y vasculature of tumors combined with a poor lymphatic system allows the passive accumulation, and su

75 s well as in the growth and expansion of the lymphatic system and associated pathways have been ident

76 its propensity to rapidly disseminate to the lymphatic system and distant organs.

77 that the lacteal is a unique organ-specific lymphatic system and does not merely serve as a passive

78 pact immunosuppressive therapies have on the lymphatic system and emerging evidence of organ-specific

79 ent and regulation of the cardiovascular and lymphatic system and has therefore gained significant in

80 lear how tumor cells make their way into the lymphatic system and how they choose between lymphatic a

81 biology: its continuous transit through the lymphatic system and its potential involvement in lymph

82 uggests that this involves regulation of the lymphatic system and may have implications in understand

83 phatic imaging are visualization of the deep lymphatic system and perforating lymphatic vessels.

84 by the accumulation of CD5(+) B cells in the lymphatic system and peripheral blood.

85 be of sufficient size to be retained by the lymphatic system and permit the conjugation or incorpora

86 hangiography may elucidate the complex human lymphatic system and reduce the risk of lymphedema after

87 ease, but the relationship between the renal lymphatic system and renal function is unclear.

88 delivery of unmodified LPV to the mesenteric lymphatic system and resulted in undetectable levels of

89 y, we harness the draining properties of the lymphatic system and show that also non-linked VLPs are

90 th all three QDs to distinctly visualize the lymphatic system and spatially overlapping vasculature n

91 required regulator of the development of the lymphatic system and that the vascular and lymphatic sys

92 meningeal immunity, especially the meningeal lymphatic system and the glymphatic system, is relativel

93 we review the structure and function of the lymphatic system and then focus on the factors that lead

94 ted in its ability to colonize organs of the lymphatic system and to cause systemic disease in mice.

95 ation of Th1 effector cells both through the lymphatic system and to sites of inflammation.

96 Here, the lymphatic system and transport across the endothelial ba

97 ies, whereas congenital abnormalities of the lymphatic system and trauma are commonest in children.

98 ight emerging application areas, such as the lymphatic system, and close the review discussing potent

99 d tumor cells, immunomodulatory roles of the lymphatic system, and contribution of the intestinal mic

100 easible, produces good images of the central lymphatic system, and demonstrates the time course of fl

101 f breast cancer occurs primarily through the lymphatic system, and the extent of lymph node involveme

102 most common site of infection is within the lymphatic system, and there is growing recognition that

103 ng nanodevices incorporated in the blood and lymphatic systems, and adapted for molecular event recor

104 heir transit through the hematogenous and/or lymphatic systems, and ending with their entrance into t

105 chanisms by which tumor cells infiltrate the lymphatic system are not completely understood.

106 Developmental and functional defects in the lymphatic system are responsible for primary lymphoedema

107 r the pathological effects of obesity on the lymphatic system are reversible with behavioural modific

108 chanisms regulating their migration into the lymphatic system are still poorly understood.

109 Two major functions of the lymphatic system are the reabsorption of excess intersti

110 ucial to the development and function of the lymphatic system are used as a basis for understanding n

111 ultiple routes, and glymphatic and meningeal lymphatic systems are functionally connected.

112 The findings establish the lymphatic system as both a survival niche and conduit to

113 dysfunctions observed in CD and suggest the lymphatic system as new target for therapeutic options.

114 for studying the anatomy and flow within the lymphatic system as well as in some limited clinical set

115 ons (LMs) are developmental anomalies of the lymphatic system associated with the dysmorphogenesis of

116 telets in preventing blood from entering the lymphatic system at the LV junction.

117 ls, often metastasize regionally through the lymphatic system before metastasizing systemically throu

118 The vascular and lymphatic systems both comprise a series of structurally

119 its dissemination via host cells through the lymphatic system but can be blocked by prevention of leu

120 of cannabinoids recovered in the intestinal lymphatic system, but not in plasma, were substantially

121 or Prox1 is essential for development of the lymphatic system by specifying lymphatic endothelial cel

122 sufficient to control fluid transport in the lymphatic system: Ca(2+)-mediated contractions can be tr

123 cerned with whether latent merozoites in the lymphatic system can give rise to relapse-like, recurren

124 These results suggest that the cardiac lymphatic system can influence the regenerative potentia

125 normal development and/or functioning of the lymphatic system, can present in isolation or as part of

126 delineated with the discovery of a meningeal lymphatic system capable of carrying fluid, immune cells

127 Background Abnormalities of the central lymphatic system (CLS) are increasingly treated by inter

128 o enhance the delivery of CAB and RPV to the lymphatic system compared to the IM delivery route.

129 The lymphatic system comprises blind-ended tubes that collec

130 The lymphatic system consists of a vessel network lined by s

131 The lymphatic system contains intraluminal leaflet valves th

132 Throughout the body, the lymphatic system contributes to homeostatic mechanisms b

133 via the conjunctival or periocular blood and lymphatic systems contributes significantly to drug clea

134 The lymphatic system controls fluid homeostasis and the clea

135 tribution of immune cells in the mucosa, the lymphatic system controls leukocyte exit, bacterial clea

136 Deleterious effects of obesity on the lymphatic system correlate with weight gain.

137 e lymphatic system and that the vascular and lymphatic systems develop independently.

138 mammals are conserved and that the zebrafish lymphatic system develops early enough to allow in vivo

139 documenting the precise manner by which the lymphatic system develops.

140 m]; 1.17 [1.06-1.29]; p=0.001) and blood and lymphatic system disorders (114 [0.88% per annum] vs 80

141 of neurological disorders, the presence of a lymphatic system draining the CNS potentially offers a n

142 ous junction, the site in the body where the lymphatic system drains into the blood vascular system,

143 rent knowledge of alterations in the hepatic lymphatic system during liver malignancies, as well as v

144 mor cells frequently disseminate through the lymphatic system during metastatic spread of breast canc

145 clinical trials investigated the role of the lymphatic system during protein absorption, following a

146 abnormal soft tissue swelling and caused by lymphatic system dysfunction.

147 These observations suggest that a lymphatic system exists for the transport of immune cell

148 The mechanisms by which the lymphatic system extracts fluid from these tissues again

149 ongestive heart failure occurs only when the lymphatic system fails or is overrun by fluid leaving th

150 The brain lacks a traditional lymphatic system for metabolite clearance.

151 trast to the blood vascular circulation, the lymphatic system forms a unidirectional transit pathway

152 maging of lymph flow is key to understanding lymphatic system function in normal and disease states.

153 We conclude that the mammalian lymphatic system has a solely venous origin.

154 Recently, it has been proposed that the lymphatic system has an active role in metastatic dissem

155 The lymphatic system has become the subject of great interes

156 Recent progress on the central lymphatic system has greatly increased our understanding

157 In recent years, the lymphatic system has received increasing attention due t

158 Since its recent discovery, the meningeal lymphatic system has reshaped our understanding of centr

159 lack of simple diagnostic tools to study the lymphatic system have led to an underappreciation of the

160 on around lymphatic endothelium congests the lymphatic system, impairing fluid and cellular flow from

161 d escape of bacteria from the colon into the lymphatic system in a dextran sodium sulfate mediated mo

162 sport, point to a key role of the glymphatic-lymphatic system in clearance of amyloid-beta and other

163 call for a reexamination of the role of the lymphatic system in CNS physiology and disease.

164 genetic and experimental manipulation of the lymphatic system in currently available model organisms.

165 The specific roles of the lymphatic system in edema, genetic aspects of primary ly

166 tle is known about the role of the meningeal lymphatic system in HE.

167 w the known, pertinent features of the human lymphatic system in health and disease and set the conte

168 he NIH workshop entitled "Yet to be Charted: Lymphatic System in Health and Disease," held in Septemb

169 dence demonstrating the dysregulation of the lymphatic system in HF.

170 in the development of the blood vascular and lymphatic system in mice, and has been characterized as

171 this study, we investigated the roles of the lymphatic system in skin carcinogenesis and psoriasis-li

172 the recently discovered glymphatic-meningeal lymphatic system in TBI pathogenesis.

173 The lymphatic system in teleost fish has genetic and develop

174 The existence of a lymphatic system in teleosts has been a matter of debate

175 The glymphatic system is the analog of the lymphatic system in the CNS.

176 er, we discuss the opportunity to target the lymphatic system in the management of HF and different p

177 Recent research has implicated the lymphatic system in the pathogenesis of cardiovascular d

178 or of neutrophil trafficking into and within lymphatic system in vivo.

179 in, we discuss the physiological role of the lymphatic system in volume management and the evidence d

180 The discovery of glymphatic and lymphatic systems in the brain and the recently unveiled

181 es evidence of both glymphatic and meningeal lymphatic systems in the most well-studied cetacean, the

182 imaging clearly visualized most of the mouse lymphatic system, including both lymphatics and lymph no

183 The mesenteric lymphatic system, including mesenteric lymph nodes (MLNs

184 s required for the normal development of the lymphatic system, including the thoracic duct, and that

185 istribution from the gut, likely through the lymphatic system, increasing AHR activation in key barri

186 The lymphatic system is a common avenue for the spread of br

187 As the lymphatic system is a critical regulator of inflammatory

188 Unassisted metastasis through the lymphatic system is a mechanism of dissemination thus fa

189 The lymphatic system is active in several processes that reg

190 The lymphatic system is an important pathway for tumor disse

191 The lymphatic system is an important route for cancer dissem

192 The lymphatic system is an integral part of the circulatory

193 Dysfunction of the lymphatic system is associated with a wide range of dise

194 This specialization of the lymphatic system is associated with fish in the family S

195 Fluorescence-guided assessment of the lymphatic system is both feasible and effective for sent

196 The lymphatic system is crucial for efficient immune surveil

197 The lymphatic system is crucial for fluid homeostasis, immun

198 The lymphatic system is essential for the generation of immu

199 The lymphatic system is essential for the maintenance of tis

200 The lymphatic system is fundamentally important to cardiovas

201 The lymphatic system is important in tissue fluid balance re

202 While the lymphatic system is increasingly associated with disease

203 The lymphatic system is involved in various biological proce

204 A functioning lymphatic system is necessary not only to permit the org

205 Throughout the body, the lymphatic system is responsible for clearing metabolic w

206 The lymphatic system is responsible for transporting interst

207 The major function of the lymphatic system is to drain interstitial fluid from tis

208 such forces similarly influence the low-flow lymphatic system is unknown.

209 Leishmania parasites spread via the lymphatic system, leading to disease progression.

210 uted throughout the body and embedded in the lymphatic system, local lymph nodes are continuously inf

211 The lymphatic system (LS) is composed of lymphoid organs and

212 The glymphatic and meningeal lymphatic systems maintain CNS homeostasis by distributi

213 The lymphatic system maintains tissue fluid balance, and dys

214 The lymphatic system maintains tissue fluid balance, and its

215 the nasal mucosa followed by entry into the lymphatic system may be a mechanism that underlies the e

216 The discovery of the central nervous system lymphatic system may call for a reassessment of basic as

217 st that therapeutics targeting the meningeal lymphatic system may offer strategies to treat TBI.

218 the interplay between diet, obesity, and the lymphatic system modulate systemic complications of obes

219 To map the drainage patterns of the lymphatic system, multicolor optical probes must be deve

220 t recirculate through blood, tissues and the lymphatic system of an animal with body mass M.

221 venous sinuses, recapitulates the meningeal lymphatic system of rodents.

222 Here, we show that the lymphatic system of tunas functions in swimming hydrodyn

223 The demonstration of a choroidal lymphatic system opens new insights into the processes o

224 le is known about cancer progression via the lymphatic system or of the effect that the lymphatic env

225 r the large intestine is covered by the same lymphatic system or represents its own lymphoid compartm

226 evolve the capacity to intravasate into the lymphatic system or vasculature, and extravasate into an

227 reased risk of tumors of the hemopoietic and lymphatic systems (OR = 3.8, 95% CI 1.0-14.3), with the

228 in women (gallbladder, kidney, liver, lung, lymphatic system, ovaries, pancreas, stomach, uterus, ce

229 olorectum, gallbladder, kidney, liver, lung, lymphatic system, pancreas, and stomach) and 11 site-spe

230 Collateral pathways of the superficial lymphatic system, perforating lymphatic vessels, and the

231 The lymphatic system plays a critical role in the maintenanc

232 Since the lymphatic system plays a crucial role in regulating and

233 The lymphatic system plays a crucial role in the alloimmune

234 antation, and emerging evidence suggests the lymphatic system plays a key role in shaping outcomes.

235 The lymphatic system plays a key role in tissue fluid homeos

236 The lymphatic system plays a key role in tissue fluid homeos

237 The lymphatic system plays a key role in tissue fluid homeos

238 l tissue to draining lymph nodes (dLNs), the lymphatic system plays a pivotal role in initiating the

239 The lymphatic system plays an active role in modulating infl

240 The lymphatic system plays an important role in cancer metas

241 The lymphatic system plays an integral part in fluid homeost

242 phatic vascular system, it is clear that the lymphatic system plays an integral role in physiology, a

243 The lymphatic system plays complex, often contradictory, rol

244 The lymphatic system plays critical roles in fluid homeostas

245 The lymphatic system possesses the main viral replication si

246 The lymphatic system regulates interstitial tissue fluid bal

247 The lymphatic system relies on orchestrated contraction of c

248 The lymphatic system relies on robust, spontaneous contracti

249 intense study, the effects of obesity on the lymphatic system remain essentially unknown.

250 and a closely related factor, FOXC1, in the lymphatic system remains largely unknown.

251 tem, and the recent studies on the meningeal lymphatic system represent an emblematic example.

252 As such, the glymphatic-lymphatic system represents a new target in combating ne

253 suggest that obesity-induced changes in the lymphatic system result in an amplified and a prolonged

254 Moreover, lymphatic system's response to inflammation within human

255 e peritoneal cavity due to disruption of the lymphatic system secondary to traumatic injury or obstru

256 In different organs and tissues, the lymphatic system serves as a drainage system for interst

257 activated for targeted migration through the lymphatic system, similar to dendritic cells (DCs) durin

258 wever, the physiologic role of LYVE-1 in the lymphatic system still remains unclear.

259 and pathologies that indirectly involve the lymphatic system, such as inflammation, obesity and meta

260 among pathologies that directly involve the lymphatic system, such as inherited and acquired forms o

261 is in a variety of diseases that involve the lymphatic system, such as lymphedema or lymphatic metast

262 red orally and, therefore, cannot access the lymphatic system sufficiently to interrupt this viral re

263 ent studies revealing a functional meningeal lymphatic system that drains cerebrospinal fluid (CSF) t

264 g and studying lymphatic development, with a lymphatic system that shares many of the morphological,

265 e development and structure of the meningeal lymphatic system, the contribution of this network in ev

266 rstanding of the embryology of the mammalian lymphatic system, the recent isolation of pure populatio

267 on and convection of drug molecules into the lymphatic system through the hybrid vessel network.

268 on of ERalpha and impaired regulation of the lymphatic system through the transcription factor prospe

269 ement at the interface between the blood and lymphatic systems, thus enabling tissue-derived antigen

270 underappreciation of the contribution of the lymphatic system to acute and chronic heart failure (HF)

271 Due to the relevant contribution of the lymphatic system to human physiology, while this review

272 to specific locations within tissues and the lymphatic system to support tissue-localized immune reac

273 e for flow of the contrast agent through the lymphatic system to the TD thoracic duct outlet was 244

274 t from anterior trunk MM also occurs via the lymphatic system to these intramammary in-transit sentin

275 accumulation of different tattoo inks in the lymphatic system using a murine model.

276 glycosaminoglycans from the circulatory and lymphatic systems via coated pit-mediated uptake.

277 ial lymph nodes of the beagles indicated the lymphatic system was effective in clearing deposited plu

278 Dissemination through the lymphatic system was evaluated as an underlying mechanis

279 stigate the impact of RASA1 mutations in the lymphatic system, we performed investigational near-infr

280 reviewing the anatomy and physiology of the lymphatic system, we review physiologic principles of ly

281 perforating lymphatic vessels, and the deep lymphatic system were implicated in preventing or reduci

282 xcess risks of tumors of the hemopoietic and lymphatic systems were observed throughout the meat indu

283 ymphedema is a developmental disorder of the lymphatic system which leads to a disabling and disfigur

284 d into the hand dermis, drained into the arm lymphatic system which was imaged using a gamma-camera.

285 al origins similar to those of the mammalian lymphatic system, which is involved in immune response a

286 mprovement, with remodeling of the patient's lymphatic system with resolution of the lymphatic edema,

287 emonstrate that the lens is connected to the lymphatic system, with LYVE(+) labeling reaching the len