ライフサイエンスコーパス: lymphoid organ

1 of the overall architecture of that primary lymphoid organ.

2 in alloantibody production within a tertiary lymphoid organ.

3 sms that give rise to this ectopic, tertiary lymphoid organ.

4 ontextually shape the milieu in this primary lymphoid organ.

5 l tissue into one that resembles a secondary lymphoid organ.

6 o explore whether it functions as a tertiary lymphoid organ.

7 le-negative (DN) T cells, in mouse secondary lymphoid organs.

8 ncreased with tumor growth but was absent in lymphoid organs.

9 ng their recruitment to inflamed tissues and lymphoid organs.

10 ile excessive IL-22 induced atrophy in these lymphoid organs.

11 e maintenance of naive T cells in peripheral lymphoid organs.

12 tration with increased formation of tertiary lymphoid organs.

13 its effects remain unclear, particularly in lymphoid organs.

14 hroughout the intestine but rare in systemic lymphoid organs.

15 highly specialized immune cells in secondary lymphoid organs.

16 reg) with a significant decrease of iTreg in lymphoid organs.

17 ed early IL-22 production from the liver and lymphoid organs.

18 tream and the trafficking of T cells through lymphoid organs.

19 tory T cells in atherosclerotic arteries and lymphoid organs.

20 een on a majority of CD8(+) TILs, but not in lymphoid organs.

21 nd expanded B cell compartments in secondary lymphoid organs.

22 gnal was paralleled by CXCR4 upregulation in lymphoid organs.

23 e germinal center (GC) reaction in secondary lymphoid organs.

24 ffective trafficking of PrP(Sc) to secondary lymphoid organs.

25 affected tissue typically develops tertiary lymphoid organs.

26 e into nodules that may mature into tertiary lymphoid organs.

27 n of DN T cells in the kidneys and secondary lymphoid organs.

28 (+) B lymphocytes in blood, bone marrow, and lymphoid organs.

29 tical for the egress of T and B cells out of lymphoid organs.

30 re associated with the induction of tertiary lymphoid organs.

31 ) T cells to the inflamed skin and secondary lymphoid organs.

32 iently trigger immune responses in secondary lymphoid organs.

33 within atherosclerotic lesions or secondary lymphoid organs.

34 cell frequency in the thymus and peripheral lymphoid organs.

35 affecting naive T cell entry into secondary lymphoid organs.

36 8(+) DP cells in peripheral lymphoid and non-lymphoid organs.

37 cterized by contracted populations homing to lymphoid organs.

38 , most cellular immune interactions occur in lymphoid organs.

39 .g., hematopoietic bone marrow and secondary lymphoid organs.

40 ocyte glycoprotein (MOG)-specific T cells in lymphoid organs.

41 as well as their potential functions in non-lymphoid organs.

42 pendent of T-cell trafficking from secondary lymphoid organs.

43 gesting increased homing of TFH to secondary lymphoid organs.

44 of T follicular helper cells within tertiary lymphoid organs.

45 aly/aly-spl(-)) mice devoid of all secondary lymphoid organs.

46 ed stromal niche for innate ILC3 in adaptive lymphoid organs.

47 responses both in the ocular lesions and the lymphoid organs.

48 ir proportion declines with age in secondary lymphoid organs.

49 cusing on germinal centers (GC) in secondary lymphoid organs.

50 es of inflammation, but not for migration to lymphoid organs.

51 o HO-1(+/+) donor kidneys, to the peripheral lymphoid organs.

52 velopment failed, and B cells underpopulated lymphoid organs.

53 ene expression was predominantly detected in lymphoid organs.

54 oper trafficking of lymphocytes to secondary lymphoid organs.

55 approximately 20 min) and clearly visualized lymphoid organs.

56 od circulation and shear forces unlike other lymphoid organs.

57 eveloped germinal centers (GCs) in secondary lymphoid organs.

58 functional compartmentalization of secondary lymphoid organs.

59 le in the organization of vertebrate mucosal lymphoid organs.

60 lood vessels for lymphocyte extravasation in lymphoid organs.

61 onal germinal center TFH in normal secondary lymphoid organs.

62 an occur in recipient mice lacking secondary lymphoid organs.

63 ndothelium and trafficking through secondary lymphoid organs.

64 human cord blood, BM, blood, and peripheral lymphoid organs.

65 therosclerosis and the formation of tertiary lymphoid organs.

66 ng and compartmentalization within secondary lymphoid organs.

67 for the proper position of B lymphocytes in lymphoid organs.

68 nter reaction in both secondary and tertiary lymphoid organs.

69 take place outside of primary and secondary lymphoid organs.

70 1PR1) is critical for lymphocyte egress from lymphoid organs.

71 vestigators to further fine-tune delivery to lymphoid organs.

72 mantle cell lymphoma (MCL) cells survival in lymphoid organs.

73 of antigen presentation in uninflamed distal lymphoid organs.

74 constituted up to 10% of TCRdelta+ cells in lymphoid organs.

75 s continuously recirculate between secondary lymphoid organs.

76 entiation dictates the cDC1 to cDC2 ratio in lymphoid organs.

77 T cells, which damage peripheral tissues and lymphoid organs.

78 to the reticular stromal cells in secondary lymphoid organs.

79 y in germinal centers (GCs) within secondary lymphoid organs.

80 s fail to home to lymph nodes as well as non-lymphoid organs.

81 lymphoid structure that resembles secondary lymphoid organs.

82 of immune cell populations in the lungs and lymphoid organs.

83 of antigen-specific B cells within secondary lymphoid organs.

84 edict specific immune responses occurring in lymphoid organs.

85 and IgD isotypes respond to Ag in secondary lymphoid organs.

86 cells in the lungs, reducing their access to lymphoid organs.

87 s of CCR7 and migratory ability to secondary lymphoid organs.

88 ly with innate immune responses in blood and lymphoid organs.

89 tiple tissues throughout the body, including lymphoid organs, adipose tissue, and mucosal barriers.

90 ic role for stromal cell niches in secondary lymphoid organs after allo-BMT and define a framework of

91 lation was identified in tumor and secondary lymphoid organs after immunotherapy.

92 In secondary lymphoid organs, Ag-driven B cell activation induces ter

93 we take advantage of tractable primary human lymphoid organ aggregate cultures to show that IL-21 dir

94 ent studies on human TFH cells isolated from lymphoid organ and blood samples and recent observations

95 In vivo, LysoPS was detected in lymphoid organ and spinal cord tissues and was abundant

96 and duodenal infection, with effects on both lymphoid organ and tissue immune responses.

97 robial components, they migrate to secondary lymphoid organs and activate T lymphocytes.

98 , designed to enhance targeting of secondary lymphoid organs and activation of APCs, have shown subst

99 ds to the reduction in CD8(+) T cells in all lymphoid organs and attenuates CHS response.

100 autoreactive T cells accumulate in secondary lymphoid organs and autoimmunity ensues.

101 Regulatory T (Treg) cells reside in lymphoid organs and barrier tissues where they control d

102 nt mature B cell population in the secondary lymphoid organs and blood of both humans and mice.

103 ed as continuously recirculating through the lymphoid organs and blood, lymphocytes also establish re

104 nd lymphatic vessels that resemble secondary lymphoid organs and can be induced at nonlymphoid sites

105 sts prevent lymphocyte egress from secondary lymphoid organs and cause a reduction in the number of c

106 and the regulation of S1P gradients between lymphoid organs and circulatory fluids in homeostasis ar

107 ith a decreased noradrenergic innervation of lymphoid organs and counteracted the immunosuppressive e

108 a mutant, bone marrow chimeras formed proper lymphoid organs and developed CHS and GCs.

109 of AG-16 tetramer-specific CD4(+) T cells in lymphoid organs and eyes.

110 ltaARE mice also present mesenteric tertiary lymphoid organs and have altered lymphatic transport of

111 in trafficking of naive T cells to secondary lymphoid organs and in Ag-dependent T cell activation in

112 understanding of how various DC subsets, in lymphoid organs and in the periphery, can be targeted th

113 ocated from the small intestine to secondary lymphoid organs and increased the intratumoral CD8/Treg

114 In the lymphoid organs and inflamed corneal tissues, MDSCs were

115 es or to temporal niches present in reactive lymphoid organs and inflamed tissues, structures where T

116 ters in vivo but showed comparable homing to lymphoid organs and intact in vitro migration to chemoki

117 creases the burden of bacteria in intestinal lymphoid organs and intestinal inflammation after induct

118 found that it was predominantly expressed in lymphoid organs and kidney.

119 1-deficient T cells home less efficiently to lymphoid organs and migrate more slowly through them.

120 antigen-presenting cells and lymphocytes to lymphoid organs and on to the systemic circulation.

121 receptors also control leukocyte egress from lymphoid organs and peripheral tissues.

122 2 and IL-33 increased the number of Tregs in lymphoid organs and protected mice from ischemia-reperfu

123 mes to cells found in arteries with tertiary lymphoid organs and regressing plaques while YFP+ cells

124 mmune response involves T-cell activation in lymphoid organs and subsequent migration to peripheral t

125 ly regulated the egress of Treg cells out of lymphoid organs and subsequent non-lymphoid tissue distr

126 markedly improve Ag/adjuvant co-delivery to lymphoid organs and sustain Ag presentation on dendritic

127 tary retinoids control the size of secondary lymphoid organs and the efficiency of immune responses i

128 immune cell populations in blood, secondary lymphoid organs and the renal tract is helping researche

129 lls persisted as central memory cells in the lymphoid organs and tissue-resident memory cells in the

130 direct CD4(+) T cell differentiation in the lymphoid organs and tissues.

131 ratory mouse strains ( approximately 0.1% in lymphoid organs), and lack of an appropriate mouse model

132 cross the gastrointestinal tract, peripheral lymphoid organs, and central nervous system.

133 primary purview of Tregs circulating through lymphoid organs, and homeostasis ensured mainly by their

134 dimensional analysis of NK cells from blood, lymphoid organs, and mucosal tissue sites from 60 indivi

135 nalysis of donor T cells in blood, secondary lymphoid organs, and target organs of aGvHD after BMT sh

136 S1P is higher in circulatory fluids than in lymphoid organs, and the S1P1 receptor (S1P1R) directs t

137 n proximity to germinal centers in secondary lymphoid organs, and their memory compartment also circu

138 functional T cells, have low CCL22 levels in lymphoid organs, and this can be restored by adoptive tr

139 organized similar to follicles in secondary lymphoid organs, and we provide inferential evidence for

140 l scenarios of antigen access into secondary lymphoid organs, antigen valency and cellular environmen

141 Tertiary lymphoid organs are aggregates of immune and stromal cel

142 Lymphoid organs are also home to type 3 innate lymphoid

143 at circulate in the blood and are present in lymphoid organs are an essential component of long-lived

144 ll differentiation in peripheral and mucosal lymphoid organs are incompletely understood.

145 typically naive Tr cells occupying secondary lymphoid organs are largely supported by paracrine IL-2

146 oing anti-HBV CD8(+) T cell responses in the lymphoid organs are largely unknown due to the infeasibi

147 (Tfh) cells in germinal centers of secondary lymphoid organs are pivotal for B and T cell interaction

148 tion of the inhibitory noradrenergic tone in lymphoid organs as one of the possible explanations for

149 n the peritoneal cavity (PerC) and secondary lymphoid organs as well as increased numbers of plasma c

150 In lymphoid organs associated with the gut, however, germin

151 he migration dynamics of immune cells within lymphoid organs at the steady state and on how these dyn

152 hough VSMC-LTbetaRs did not affect secondary lymphoid organs: Atherosclerosis was markedly exacerbate

153 the bloodstream and proliferate in secondary lymphoid organs before replenishing effector and memory

154 lone proliferates relentlessly in peripheral lymphoid organs, bone marrow, and blood.

155 controlling macrophage function not only in lymphoid organs but also in end organs, thereby preventi

156 Mantle cell lymphoma (MCL) accumulates in lymphoid organs, but disseminates early on in extranodal

157 tes of parasite replication and in secondary lymphoid organs, but the factors that regulate this expa

158 fective development of B cells and secondary lymphoid organs, but the role of NIK in adult animals ha

159 describe the asymptomatic infection of human lymphoid organs by IAV in children.

160 maturation in anatomically distinct sites in lymphoid organs called germinal centers (GCs).

161 lecules, and impeded Treg cell homing to non-lymphoid organs, causing CD8(+) T-cell-mediated autoimmu

162 Our results indicate that human lymphoid organ cDC2 and macrophages play complementary r

163 long been known that the thymus, the central lymphoid organ, changes markedly during pregnancy(3).

164 rong migratory capacity toward the secondary lymphoid organ chemokine CCL21 and retained a functional

165 after a year on ART, with virus in blood and lymphoid organs confirmed to be replication competent.

166 Virus-specific CD8+ T cells in the lymphoid organs contract at the resolution of virus infe

167 sites are phenotypically distinct from their lymphoid-organ counterparts, and these 'tissue' signatur

168 tudied for its function in the regulation of lymphoid organ development and B-cell maturation, the ro

169 organization, immune response, hematopoietic/lymphoid organ development, and myeloid/leukocyte differ

170 x in response to BCR stimulation, leading to lymphoid organ disorders and autoimmune manifestations.

171 microbial and dietary Ags preferentially in lymphoid organs draining mucosal barriers, likely as a r

172 ral T cell responses in the non-lymphoid and lymphoid organs during acute and persistent viral infect

173 s constitutively expressed at high levels in lymphoid organs during homeostasis, where it controls im

174 of FRCs in shaping the suppressive milieu of lymphoid organs during homeostasis.

175 CD127(+) CD8 memory precursors in secondary lymphoid organs during the contraction phase.

176 issues (NALTs), which are mucosal-associated lymphoid organs embedded in the submucosa of the nasal p

177 The thymus is a primary lymphoid organ, essential for T cell maturation and sele

178 t is maintained after migration to secondary lymphoid organs, favors preferential induction of antige

179 s also inhibited virion attachment to CD4(-) lymphoid organ fibroblastic reticular cells that mediate

180 o facilitate T-cell trafficking to secondary lymphoid organ follicles.

181 n immunodeficiency virus-1 (HIV-1) infection lymphoid organ follicular dendritic cells (FDCs) serve a

182 yndrome and allows their homing to secondary lymphoid organs for promoting tolerance.

183 f) ligand 21 in lung lymphatics and tertiary lymphoid organ formation, and then decreased as lung inj

184 on, a T-cell subset critically implicated in lymphoid organ formation, in COPD.Methods: Myeloid cell

185 n and in an inducible mouse model of ectopic lymphoid organ formation.

186 nknown due to the infeasibility of obtaining lymphoid organs from CHB patients.

187 We show that NK cells in secondary lymphoid organs from chronically SIVagm-infected African

188 Intestinal lymphoid organs from mice with deletion of LACC1 had an

189 VHD model enabled visualization of secondary lymphoid organs harboring activated donor T cells prior

190 Fetal secondary lymphoid organs have an increased frequency of Tregs and

191 ive Foxo1 mutant prevented downregulation of lymphoid organ homing molecules, and impeded Treg cell h

192 ment and hematopoietic progenitor cells, and lymphoid organ hypoplasia.

193 ens trafficking of T cells through secondary lymphoid organs, impairs the infiltration of T cells int

194 preferentially colonizes Peyer's patches, a lymphoid organ in which microfold cells (M cells) overla

195 s of FOXP3(+) T cells in blood and secondary lymphoid organs in 2D2 MOG-specific transgenic mice, and

196 cell types in peripheral blood and secondary lymphoid organs in healthy individuals and in patients w

197 e form on their surface and can easily reach lymphoid organs in intact form for optimal activation of

198 H2-DM genes on parasite dissemination toward lymphoid organs in mice, as well as activation of CD4(+)

199 arious antigens, usually form transiently in lymphoid organs in response to infection or immunization

200 led to the increased development of tertiary lymphoid organs in the aorta, and enhanced disease devel

201 w that memory T cells collapsed in secondary lymphoid organs in the context of dietary restriction (D

202 context in which B cells signal in secondary lymphoid organs in vivo or how that context influences s

203 egress and T cell lymphopenia in peripheral lymphoid organs in vivo.

204 This differs from lymphoid organs, in which immune cells adopt spatially b

205 Secondary lymphoid organs include organized MALT (O-MALT) such as

206 P) guides T cell circulation among secondary lymphoid organs, including spleen, lymph nodes and Peyer

207 1P) mediates egress of immune cells from the lymphoid organs into the lymphatic vessels; we investiga

208 the spleen is broadly accepted as the major lymphoid organ involved in generating immune responses t

209 ition within primary, secondary, or tertiary lymphoid organs is a prerequisite to ensure immune cells

210 enting cells with T lymphocytes in secondary lymphoid organs is essential for the initiation of alloi

211 but knowledge of their function in secondary lymphoid organs is incomplete.

212 The development of lymphoid organs is significantly impaired in Rag1(-/-)Ra

213 in overactivation of this axis in secondary lymphoid organs, led to the increased development of ter

214 The spleen is a large lymphoid organ located in the abdomen that filters blood

215 man expressed homing receptors for secondary lymphoid organs, mainly CD62L.

216 Significantly, FRCs of human lymphoid organs manifest similar COX-2/PGE2 hyperactivit

217 (CLL) cells requires communication with the lymphoid organ microenvironment.

218 The thymus is a primary lymphoid organ necessary for optimal T cell development.

219 In secondary lymphoid organs, NK cells compose the third most abundan

220 r, neither T cell recruitment into secondary lymphoid organs nor initial T cell activation was affect

221 hat MKP-2 mRNA levels in the spinal cord and lymphoid organs of EAE mice were increased compared with

222 chemokines and mediated homing to secondary lymphoid organs of human T lymphocytes.

223 mined that functional human ILC3s develop in lymphoid organs of humanized mice and that persistent HI

224 Through the analysis of GFP expression in lymphoid organs of IL-21eGFP mice, we identified a subpo

225 rred MDSCs were primarily recovered from the lymphoid organs of recipients.

226 donor passenger leukocytes to the secondary lymphoid organs of the recipient to elicit an immune res

227 ction of the cytokine IL-10 in the secondary lymphoid organs of vaccinated mice.

228 e structures (ELSs) reminiscent of secondary lymphoid organs often develop at sites of chronic inflam

229 Although proliferation remains located in lymphoid organs only, suggesting a major role of the tum

230 f DC and lymphocyte positioning in secondary lymphoid organs over time has led to a clearer understan

231 ase of the intestinal tract, report tertiary lymphoid organs present within the mucosal wall, along w

232 Cholesterol accumulation in lymphoid organs promoted T cell priming and stimulated t

233 ive T cells that circulate through secondary lymphoid organs ready to be activated upon pathogenic ch

234 Mouse artery tertiary lymphoid organs recruit large numbers of naive T cells a

235 ates that cellular trafficking from tertiary lymphoid organs regulates immune responses in the periph

236 unction of lymphatic vessels within tertiary lymphoid organs remains poorly understood.

237 The thymus is a primary lymphoid organ required for the induction and maintenanc

238 he subsequent activation of cross-presenting lymphoid organ-resident CD8alpha(+) DCs.

239 ties and differences between mouse and human lymphoid organ-resident TFH cells and discuss the role o

240 ease and subsequent maintenance of secondary lymphoid organ-resident Tr cells are still poorly unders

241 The thymus is the primary lymphoid organ responsible for generating T cells in ver

242 te trafficking from the thymus and secondary lymphoid organs, resulting in immunosuppression.

243 phylogenetic trees of GC BCRs from secondary lymphoid organs revealed that the vast majority of CSR e

244 etween CD8+ memory T cells in peripheral vs. lymphoid organs, revealing a novel tissue-specific parad

245 and result in T cell tolerance through host lymphoid organ selection.

246 a and altered T-cell cytokines in intestinal lymphoid organs, similar to Lacc1(-/-) mice.

247 Here, we identify a subset of lymphoid organ sinus lining macrophage (SMs) that provid

248 Secondary lymphoid organs (SLO) provide the structural framework f

249 that enable homing and egress from secondary lymphoid organs (SLO).

250 nfected distinct CD4(+) T cells in secondary lymphoid organs (SLOs) and within the lamina propria of

251 Secondary lymphoid organs (SLOs) are important initiators and regu

252 of the pathogen and the underlying secondary lymphoid organs (SLOs) needs to be established to prime

253 cribed to circulate between blood, secondary lymphoid organs (SLOs), and lymph in the steady state.

254 d to decreased T-cell migration to secondary lymphoid organs (SLOs), reduced in vivo proliferation wi

255 e progression of autoreactivity in secondary lymphoid organs (SLOs), we characterized the localizatio

256 e unable to migrate efficiently to secondary lymphoid organs (SLOs).

257 (Sc)) changes with colonization of secondary lymphoid organs (SLOs).

258 approximately 25% of mice lacking secondary lymphoid organs spontaneously develop specific antinucle

259 ting immune sentinels that convey signals to lymphoid organ stroma and thereby facilitate immune resp

260 and/or cysteine depletion, was found in the lymphoid organs, such as the spleen and lymph nodes.

261 This contrasts with lymphoid organs, such as the spleen and mesenteric lymph

262 th characteristics reminiscent of a tertiary lymphoid organ, suggesting the creation of a microenviro

263 s are localized in T cell zones of secondary lymphoid organs, suppress activation and expansion of CD

264 demonstrate that distinct niches within the lymphoid organ T zone support distinct cell fate decisio

265 cells were more likely to be resident within lymphoid organs than CD8(+) T cells.

266 is first observed in the thymus, the primary lymphoid organ that generates and selects T cells.

267 The thymus is a primary lymphoid organ that plays an essential role in T lymphoc

268 lerance, Foxp3+ cells accumulate in tertiary lymphoid organs that are induced within the pulmonary gr

269 nce and function of the immune system and on lymphoid organs that coordinate both the maintenance of

270 gp38(+) fibroblasts, which resemble tertiary lymphoid organs that develop in models of chronic inflam

271 tion of Peyer's patches (PP), gut-associated lymphoid organs that have a key role in the initiation o

272 rosclerotic lesions, as well as in secondary lymphoid organs, the bone marrow and the blood.

273 reside within B cell follicles in secondary lymphoid organs, they are challenging to study in humans

274 ific B cells arrive in Ag-draining secondary lymphoid organs, they may join the ongoing GC response.

275 Although these mice exhibited normal lymphoid organs, they were defective in cross-priming na

276 ting adaptive immune responses in peripheral lymphoid organ tissues, how DCs infiltrate the CNS and c

277 The series of events leading to tertiary lymphoid organ (TLO) formation in mucosal organs followi

278 Tertiary lymphoid organs (TLOs) emerge during nonresolving periph

279 , B-cell-rich aggregates resembling tertiary lymphoid organs (TLOs) impinged on lymphatic collecting

280 vidence supports a crucial role for tertiary lymphoid organs (TLOs) in chronic obstructive pulmonary

281 e characterized by the formation of tertiary lymphoid organs (TLOs).

282 CCL21, leading to the formation of tertiary lymphoid organs (TLOs).

283 sts that they undergo selection in recipient lymphoid organs to acquire immune tolerance.

284 ty to direct immunomodulators to tumours and lymphoid organs, to alter the way biologics engage with

285 ing Treg (rTreg) cell phenotype in secondary lymphoid organs, Treg cells in non-lymphoid tissues exhi

286 ention of memory T cell subsets in secondary lymphoid organs, via S1PR2.

287 b-, and dsPMCAb-derived PrP(Sc) to secondary lymphoid organs was monitored in wild type mice.

288 Because NIK-deficient mice lack secondary lymphoid organs, we generated transgenic mice with targe

289 l conditions within discrete nonlymphoid and lymphoid organs, we show that IL-10 production by CD4(+)

290 the effector/memory phenotype in peripheral lymphoid organs when compared with Cd4[Cre] mice express

291 ess as recent thymic emigrants to peripheral lymphoid organs where they undergo an additional maturat

292 e back and forth between blood and secondary lymphoid organs, whereas in the second, memory cells rec

293 activated by self-draining OVA+CAF09 in the lymphoid organs, whereas the CD103(+) DCs are stimulated

294 howed uptake in the tumor, spleen, and other lymphoid organs, whereas the human-specific control BiTE

295 T cells proved hyporesponsive in peripheral lymphoid organs, whereas they retained effector function

296 We propose that the restriction of oxygen in lymphoid organs, which can be altered in pathophysiologi

297 n increased burden of bacteria in intestinal lymphoid organs, which expressed lower levels of T helpe

298 self-drainage of the adjuvant/antigen to the lymphoid organs, which takes place upon i.p. immunizatio

299 om these sites to naive T cells in secondary lymphoid organs while also providing multiple soluble an

300 s the TPO-specific T(reg) are present in all lymphoid organs with the exception of the thyroid-draini