ライフサイエンスコーパス: lymphopenic

1 ers the rat diabetes resistant despite being lymphopenic.

2 n Jak3 plus p53 or in Jak3 plus Fas remained lymphopenic.

3 At baseline, patients were profoundly lymphopenic.

4 llele (f/f) between D4Rat253 and D4Rhw6 were lymphopenic (85 of 85, 100%) but did not develop diabete

5 icient form of the BAFF-R derived from the B lymphopenic A/WySnJ strain.

6 hat in times of need, such as in neonates or lymphopenic adults, RTEs perform well to fill the gaps i

7 gnificant expansion in AML patients rendered lymphopenic after chemotherapy, contributing to the repo

8 enic diabetes-resistant (DR) BB rats are not lymphopenic and are free of spontaneous autoimmune disea

9 DP-BB rats are consequently lymphopenic and circulate severely reduced numbers of T

10 Rapa inhibition is relative and results from lymphopenic and graft-versus-host disease models cannot

11 S correlated with global disease activity in lymphopenic and non-lymphopenic patients and decreased f

12 cells and is modeled in many respects by the lymphopenic and spontaneously diabetic BioBreeding (BB)

13 ften effective; however, in patients who are lymphopenic and/or heavily pretreated with chemotherapy,

14 is complicated because of the involvement of lymphopenic animals, as lymphopenia drastically alters n

15 aive, CD25-depleted, betagalTCR T cells into lymphopenic arrbetagal recipients, implicating regulator

16 (+) T cells could reconstitute mice rendered lymphopenic as a consequence of genetics, irradiation, o

17 Kdelr1 homozygous mutants were mildly lymphopenic, as were mice with a CRISPR/Cas9-engineered

18 Neonates were lymphopenic at birth (1118 +/- 128 lymphocytes per cubic

19 nly the patients receiving Cy/Flu/DLI became lymphopenic at the time of DLI.

20 dTg TCR/HEL mice are profoundly lymphopenic at weaning.

21 Lymphopenic, autoimmune lupus erythematosus patients exh

22 PARgamma-deficient (T-PPAR) Teffs to mediate lymphopenic autoimmunity is associated with a significan

23 ject Balb/c skins upon further transfer into lymphopenic B6.Rag1(-/-) mice.

24 e carrying superantigen were severely B cell lymphopenic, but small numbers of B cells matured.

25 nt, which is only revealed in hosts rendered lymphopenic by neonatal thymic ablation.

26 In this study, we report that in lymphopenic CD24-deficient mice, T cells launch a massiv

27 T cells could not completely treat tumor in lymphopenic common gamma chain (gamma(c))-deficient host

28 homeostasis of the CD4 memory population in lymphopenic conditions and in the intact immune system.

29 ile that can be temporarily overridden under lymphopenic conditions but is inevitably reimposed, whic

30 21R, we discovered that under homeostatic or lymphopenic conditions IL-21 acts directly on CD8 T cell

31 D4(+) T cells accumulated in old mice, under lymphopenic conditions in a T cell transfer model of col

32 naive T cells is observed readily only under lymphopenic conditions in response to elevated levels of

33 ation of naive TRAF6DeltaT CD8 T cells under lymphopenic conditions is defective.

34 e proliferation of CD4+ T cells under severe lymphopenic conditions, and this division is associated

35 rom MHC II(-/-) mice hyperproliferated under lymphopenic conditions, differentiated into effector cel

36 Conversely, under lymphopenic conditions, enhanced proliferation by RTEs a

37 ells proliferate and become functional under lymphopenic conditions, even in a tolerogenic environmen

38 opoietic stem cell transplantation and other lymphopenic conditions, IL-7 plays an important role in

39 interleukin 7 (IL-7) levels are observed in lymphopenic conditions, including idiopathic CD4 lymphop

40 ls lacking both E2F1 and E2F2 in response to lymphopenic conditions, suggesting that E2F1 and E2F2 fu

41 In lymphopenic conditions, T cells expand to re-establish h

42 The findings suggest that under uniform lymphopenic conditions, the widely different rates of pr

43 aive T cells undergo robust proliferation in lymphopenic conditions, whereas they remain quiescent in

44 Production of HCs is induced in lymphopenic conditions, which have been shown to predisp

45 ulate homeostatic T cell proliferation under lymphopenic conditions.

46 ivo complexity of T-cell proliferation under lymphopenic conditions.

47 survival and homeostatic proliferation under lymphopenic conditions.

48 CD8(+) T cell homeostasis in both normal and lymphopenic conditions.

49 y T cells as a result of proliferation under lymphopenic conditions.

50 n during normal homeostasis as well as under lymphopenic conditions.

51 roliferation rates of NK cells in normal and lymphopenic conditions.

52 ete for homeostatic factors under normal and lymphopenic conditions.

53 c expansion capacity of memory T cells under lymphopenic conditions.

54 e process of homeostatic proliferation under lymphopenic conditions.

55 trolling lymphopoiesis under both normal and lymphopenic conditions.

56 ned the ability to proliferate in vivo under lymphopenic conditions.

57 quired for development of autoimmunity under lymphopenic conditions.

58 s from donor mice with or without cGvHD into lymphopenic congenic recipients showed that cGvHD impair

59 tion differentially in nonlymphopenic versus lymphopenic contexts.

60 aberrations, and mortality in patients with lymphopenic COVID-19.

61 In response to a lymphopenic cue, T lymphocytes undergo a slow-paced home

62 imap5-deficient cells lose weight and become lymphopenic, demonstrating a hematopoietic cell-intrinsi

63 IL-15Ralpha-/- mice are markedly lymphopenic despite grossly normal T and B lymphocyte de

64 CD4Cre/R-DTA mice remained lymphopenic despite the large available immunological "s

65 Congenitally lymphopenic diabetes-prone (DP) BioBreeding (BB) rats de

66 utes a larger percentage of the euthymic but lymphopenic diabetes-prone BB rat IEL population, and is

67 ing 1-deficient (SOCS1(-/-)) mice, which are lymphopenic, die <3 wk after birth of a T cell-mediated

68 s with SCID, as well as infants with other T-lymphopenic disorders detected by using NBS.

69 Cell transfers into lymphopenic DNASE1L3-deficient mice showed that TLR2 was

70 Mice lacking interleukin-7 receptor are lymphopenic, due to a defect in cell expansion at an ear

71 ule (PT) cells, independent of the canonical lymphopenic effects of S1P1 activation on B and T cells.

72 T cell proliferation occurs in response to a lymphopenic environment and is mediated by TCR and IL-7

73 evelopment or homeostatic proliferation in a lymphopenic environment are not required for this severe

74 ntial expansion of effector memory T-cell in lymphopenic environment could represent the major barrie

75 In this study, we show that the physiologic lymphopenic environment existing in neonatal mice also s

76 ive T cells have the capacity to expand in a lymphopenic environment in a process called homeostatic

77 Remarkably, this defect occurred despite the lymphopenic environment in LP hosts.

78 It has been shown that in a lymphopenic environment naive T cells undergo expansion

79 CD8+ T cells were introduced either into the lymphopenic environment of RAG2(-/-) mice or into P14/RA

80 creased proliferative renewal because of the lymphopenic environment of the mice.

81 te effective antitumor immunity in a defined lymphopenic environment through DC-based immunization.

82 Under the pressure of a T lymphopenic environment, mature naive T cells begin to p

83 In a lymphopenic environment, naive T cells undergoing homeos

84 d 4M attempt cell cycling in response to the lymphopenic environment, neither group numerically recov

85 meostasis is affected by an inflammatory and lymphopenic environment, we characterized the Treg compa

86 phoreplete mice and their proliferation in a lymphopenic environment, whereas survival and homeostati

87 ALT) after oral exposure to antigen and in a lymphopenic environment.

88 ) resembling the proliferation observed in a lymphopenic environment.

89 hocytes undergo homeostatic proliferation in lymphopenic environment.

90 ells, undergo homeostatic proliferation in a lymphopenic environment.

91 mphoid compartment, but was unnecessary in a lymphopenic environment.

92 different times after their transfer into a lymphopenic environment.

93 oietic and immune cells into an inflamed and lymphopenic environment.

94 T cells undergo this type of expansion in a lymphopenic environment.

95 even agonist-driven autoimmune disease in a lymphopenic environment.

96 pansion of T cells from young mice to fill a lymphopenic environment.

97 populations proliferated in a sepsis-induced lymphopenic environment; however, due to the intrinsic d

98 The host responds to lymphopenic environments by acute homeostatic proliferat

99 The host responds to lymphopenic environments by acute homeostatic proliferat

100 ate homeostatic CD8+ T cell proliferation in lymphopenic environments by competing for IL-15.

101 Lymphopenic environments lacking these key factors suppo

102 Introduction of naive cells into lymphopenic environments results in proliferation and di

103 T cells present in lymphopenic environments undergo spontaneous (homeostati

104 In lymphopenic environments, secondary lymphoid organs regu

105 mediate mild and persistent inflammation in lymphopenic environments, whereas naive cells exhibit st

106 T cells during homeostatic reconstitution of lymphopenic environments.

107 pendent on IL-21 for optimal accumulation in lymphopenic environments.

108 igen stimulation when transferred into adult lymphopenic environments.

109 ry of CD25(+) regulatory T cells following a lymphopenic event can prevent exuberant Ag-stimulated CD

110 -line therapy for influenza in patients with lymphopenic hematological conditions and uptake of influ

111 lonal size instead of filling the space in a lymphopenic host appears to regulate homeostatic T-cell

112 g adoptive transfer of CD8(+) T cells into a lymphopenic host can augment the therapeutic antitumor r

113 lf-renew and maintain enhanced function in a lymphopenic host for at least a month.

114 Naive T cells dividing in a lymphopenic host upregulate CD44, CD122 (interleukin 2 r

115 ility to rapidly expand upon transfer into a lymphopenic host.

116 In addition, lymphopenic hosts accumulate increased levels of IL-7, a

117 BTLA agonism rebalances T cell expansion in lymphopenic hosts after aHSCT, thereby preventing GVHD w

118 expansion of naive CD8+ and CD4+ T cells in lymphopenic hosts and for CD8+ T cell survival in normal

119 strating how TCR transgenic cells repopulate lymphopenic hosts and target tumors in an antigen-specif

120 e-like B cells when transferred into Rag2-/- lymphopenic hosts but not into wild-type hosts.

121 e to limit naive T cell proliferation within lymphopenic hosts by modulating stimulatory functions of

122 reased approximately 4-fold in reconstituted lymphopenic hosts compared with normal hosts.

123 Immune recovery in lymphopenic hosts depends largely on homeostatic periphe

124 ingly, the cells undergoing proliferation in lymphopenic hosts did not mature to cytotoxic effectors

125 Despite this, many lymphopenic hosts do not develop autoimmune disease, sug

126 Thus, T cells proliferating in lymphopenic hosts do not exhibit a unique gene-expressio

127 Lymphopenic hosts offer propitious microenvironments for

128 most quantitative studies were performed in lymphopenic hosts or in graft-versus-host disease models

129 that division of T cells in the periphery of lymphopenic hosts requires specific recognition of self-

130 Lymphopenic hosts supported increased proliferation of a

131 ts from a heightened sensitivity of infected lymphopenic hosts to the detrimental effects of Ag-drive

132 T cells transferred into severe lymphopenic hosts undergo rapid proliferation known as "

133 Expansion of CD8+ T cells in lymphopenic hosts was found to be peptide specific.

134 fect naive T cell proliferation in syngeneic lymphopenic hosts were investigated.

135 Reconstitution of lymphopenic hosts with Nod2(-/-) CD4(+) T cells or retin

136 se to self MHC molecules after transfer into lymphopenic hosts, a process that has been termed homeos

137 lphaCD25-treated lymphoreplete hosts than in lymphopenic hosts, and adoptive immunotherapy was most e

138 EGFP(-) CD4(+) T cells when transferred into lymphopenic hosts, indicative of their common ontogeny w

139 suprahomeostatic concentrations achieved in lymphopenic hosts, is a potent and selective inducer of

140 Upon transfer into MHC-II-deficient lymphopenic hosts, mature CD4(+) T cells were found to a

141 Following transfer into lymphopenic hosts, naive CD8 T cells proliferate and acq

142 This regulation is particularly active in lymphopenic hosts, such as elderly and thymectomized pat

143 the absence of functional T(reg) cells into lymphopenic hosts, T(reg) cells with deletion of Foxp3 p

144 Moreover, upon transfer into lymphopenic hosts, Th17 cells rapidly lost their IL-17 e

145 When naive T cells reconstitute lymphopenic hosts, they transiently proliferate and diff

146 gatory for proliferation of naive T cells in lymphopenic hosts, whereas IL-15 did not influence their

147 transferred CD4 T cells failed to expand in lymphopenic hosts, whereas in the presence of CCL21 over

148 lls showed enhanced homeostatic expansion in lymphopenic hosts, which was abrogated by ectopic expres

149 In lymphopenic hosts, Zap70-deficient T cells survived far

150 l-1 cells were inefficient at LIP in typical lymphopenic hosts.

151 of established tumors and depigmentation in lymphopenic hosts.

152 tantial in lymphoreplete hosts but absent in lymphopenic hosts.

153 wed cytokine responses when transferred into lymphopenic hosts.

154 immune response induced by Foxp3(-) cells in lymphopenic hosts.

155 sponse to the elevated levels of IL-7 in the lymphopenic hosts.

156 the efficacy of adoptive T-cell therapies in lymphopenic hosts.

157 ed by the transfer of CD4+CD25- T cells into lymphopenic hosts.

158 IKK2-deficient T cells to induce colitis in lymphopenic hosts.

159 n when adoptively transferred into syngeneic lymphopenic hosts.

160 ntly of cognate antigen when introduced into lymphopenic hosts.

161 stasis, and its availability is augmented in lymphopenic hosts.

162 ells when transferred together into the same lymphopenic hosts.

163 ed survival when adoptively transferred into lymphopenic hosts.

164 survival and IFN-gamma cytokine responses in lymphopenic hosts.

165 T cells that undergo "slow proliferation" in lymphopenic hosts.

166 antibiotics reduced the severity of GVHD in lymphopenic hosts.

167 s and promotes immunologic reconstitution in lymphopenic hosts.

168 he IL-7-driven immunologic reconstitution of lymphopenic hosts.

169 radoxically, elevated systemic IL-7 found in lymphopenic humans is typically insufficient for CD4(+)

170 ewborns who proved to be unaffected by any T-lymphopenic immune disorder.

171 tically deficient in IL-7R(alpha) are highly lymphopenic in the peripheral lymphoid organs.

172 ripheral T cell repertoire that occurs after lymphopenic incidents, which frequently provoke either e

173 We performed a randomized phase 1/2 study in lymphopenic individuals after high-dose chemotherapy and

174 pansion during immune reconstitution, and in lymphopenic individuals receiving IL-2, the T(reg) cell

175 All T-cell lymphopenic infants avoided live vaccines and received a

176 Other T-cell lymphopenic infants had variant SCID or combined immunod

177 unclear, and whether effector sites are also lymphopenic is unknown.

178 nt mice have normal B cell numbers but are T lymphopenic, leading to defective homeostatic expansion

179 About 20% of patients were lymphopenic, mainly because of low CD4(+) and CD8(+) T-c

180 Naive CD8+ T cells transferred to lymphopenic mice acquire a memory-like phenotype, raisin

181 a occur following experimental infections of lymphopenic mice deficient in interleukin (IL)-2/7 gamma

182 nt naive CD8(+) T cells proliferated even in lymphopenic mice deficient in major histocompatibility c

183 se cells provoke a lethal wasting disease in lymphopenic mice despite the presence of regulatory T ce

184 undergo homeostasis-driven proliferation in lymphopenic mice in the absence of overt antigenic stimu

185 ne disease, and depletion of T(reg) cells in lymphopenic mice induces autoimmunity.

186 Transfer of naive CD4 T cells into lymphopenic mice initiates a proliferative response of t

187 tory T cell-depleted polyclonal T cells into lymphopenic mice leads to rejection of B16 melanoma, whi

188 -N-nitrosourea-mutagenesis screen for T cell-lymphopenic mice prompted us to evaluate a T cell-defici

189 Adoptive transfer of mature NK cells into lymphopenic mice resulted in the generation of a long-li

190 f naive antigen-specific CD4(+) T cells into lymphopenic mice that express an endogenous antigen as a

191 of naive CD4(+) T cells and Treg cells into lymphopenic mice to assess the cell-intrinsic effects of

192 , we demonstrate that sublethally irradiated lymphopenic mice transfused with autologous or syngeneic

193 Lymphopenic mice treated with anti-PD-L1 Ab demonstrated

194 Naive CD4 T cells transferred into lymphopenic mice undergo spontaneous proliferation and i

195 at the expansion of V alpha 14i NKT cells in lymphopenic mice was not dependent on CD1d expression an

196 Lymphopenic mice were selectively reconstituted with Tre

197 ired for peripheral CD8+ T cell expansion in lymphopenic mice without conventional antigenic stimulat

198 T cells undergo homeostatic proliferation in lymphopenic mice, a process that involves TCR recognitio

199 pansion of TNFR2-deficient Teff cells in the lymphopenic mice, as well as their reduced capacity to e

200 e reported after T cells were transferred to lymphopenic mice, using Approximate Bayesian Computation

201 As in lymphopenic mice, where T cell proliferation depends upo

202 specific T cells in vaccinated reconstituted lymphopenic mice.

203 n of tumor-specific T cells in reconstituted lymphopenic mice.

204 he homeostatic expansion of naive T cells in lymphopenic mice.

205 , as well as in homeostatic proliferation in lymphopenic mice.

206 ells fail to expand and establish colitis in lymphopenic mice.

207 tly differentiate into Treg on transfer into lymphopenic mice.

208 fate (DSS) to mice or transfer of T cells to lymphopenic mice.

209 expression following adoptive transfer into lymphopenic mice.

210 thogenic than controls when transferred into lymphopenic mice.

211 However, the mechanism by which the lymphopenic microenvironment benefits Ag-specific CD8(+)

212 ansion and acquire an activated phenotype in lymphopenic microenvironments.

213 interest in the behavior of T and B cells in lymphopenic model systems has resurrected a certain cyni

214 Using experimental lymphopenic mouse models and IL-7-induced homeostatic pr

215 In a lymphopenic murine model reconstituted with naive CD4+ T

216 tness through homeostatic expansion into the lymphopenic neonatal environment.

217 ppropriate immune responses, particularly in lymphopenic neonates and adults.

218 generation of a diverse naive T cell pool in lymphopenic neonates that is mandatory for the maintenan

219 T cell clonal anergy induction in lymphopenic nu/nu mice was found to be ineffective.

220 S1P), but not to chemokines, were found in a lymphopenic patient with recurrent infections.

221 obal disease activity in lymphopenic and non-lymphopenic patients and decreased following type I IFN

222 he basis for residual protective immunity in lymphopenic patients is not known.

223 or the maintenance of protective immunity in lymphopenic patients treated for ALL.

224 uses life-threatening meningoencephalitis in lymphopenic patients.

225 ration of DCs in bone marrow (BM) during the lymphopenic phase and in the blood and spleen during the

226 cious in controlling adenoviremia during the lymphopenic phase of HCT.

227 cells that proliferate when transferred into lymphopenic (Rag-1(-/-)) hosts.

228 of large established B16BL6-D5 melanomas in lymphopenic Rag1(-/-) recipients devoid of regulatory T

229 e rapid cycle entry was observed in vivo, in lymphopenic RAG2(-/-) hosts.

230 olated and adoptively transferred into naive lymphopenic Rag2(-/-) mice.

231 Genetically lymphopenic rats and congenic wild-type partners were co

232 enotype and were able to transfer disease to lymphopenic recipient mice.

233 DLI-induced GVHD was prevented in lymphopenic recipients by prior administration of a smal

234 Transfer of the same CD4(+) T cells into lymphopenic recipients expressing the self-antigen resul

235 of naive tumor-reactive CD4(+) T cells into lymphopenic recipients induces substantial T cell expans

236 When transferred into lymphopenic recipients of male skin grafts, Th17 lines e

237 optively transferred naive CD8(+) T cells in lymphopenic recipients or recipients containing a clonal

238 betagalTCR T cells before transfer into the lymphopenic recipients reduced EAU.

239 class Ib-restricted CD8+ T cells to congenic lymphopenic recipients revealed their ability to undergo

240 cells adoptively transferred into syngeneic lymphopenic recipients undergo proliferation.

241 transfer alloantigen-specific suppression to lymphopenic recipients was described.

242 d in vivo (expansion following transfer into lymphopenic recipients).

243 eriods upon adoptive transfer into intact or lymphopenic recipients, but not in IL-7- mice or in reci

244 ced by transfer of naive CD4(+) T cells into lymphopenic recipients, DRD3 deficiency not only affects

245 cell antigen receptor, when transferred into lymphopenic recipients, naive TGF-beta-unresponsive T ce

246 However, upon transfer into lymphopenic recipients, TCE fail to rapidly expand, but

247 TCR transgenic Rag1(-/-) CD8(+) T cells into lymphopenic recipients, who received vaccination, led to

248 he initial proliferation after transfer into lymphopenic recipients.

249 nificantly higher levels after transfer into lymphopenic recipients.

250 proliferative expansion after transfer into lymphopenic recipients.

251 roliferated and induced autoimmunity only in lymphopenic recipients.

252 8 T cell proliferation and accumulation in a lymphopenic setting, as revealed by truncated LIP in IL-

253 ses of autologous T cells occur in vivo in a lymphopenic setting.

254 T helper type 2 (Th2)-mediated disease in a lymphopenic setting.

255 ive (IL-7Ralpha(+)) dendritic cells (DCs) in lymphopenic settings paradoxically diminished the homeos

256 Using a T-cell proliferation model under lymphopenic settings, we now demonstrate that gammadelta

257 eir activity might be compromised in certain lymphopenic settings.

258 In lymphopenic spleens, transferred B cells gradually lost

259 he T cell compartment during recovery from a lymphopenic state are incompletely understood.

260 The T-lymphopenic state associated with GIMAP5 deficiency rend

261 The lymphopenic state present in neonates was a factor in th

262 4 T cell homeostasis in individuals with CD4 lymphopenic states other than HIV infection.

263 Elevated serum IL-7 levels in lymphopenic states, including HIV infection, are thought

264 or inflammatory pathology that can emerge in lymphopenic states.

265 scent until they receive either antigenic or lymphopenic stimuli.

266 T of LTalpha-/- animals was disorganized and lymphopenic, suggesting that the organization and recrui

267 ne C57BL/6 splenocytes were transferred into lymphopenic T cell-deficient hosts and allowed to recons

268 lop autoimmunity after treatment are no more lymphopenic than their nonautoimmune counterparts, but t

269 atopoiesis, we observed that NHD13 mice were lymphopenic; the lymphopenia was due to a decrease in bo

270 ogical features as did fingolimod (maximally lymphopenic throughout), despite full reversal of lympho

271 Previous studies established that a lymphopenic transitional (TR) B cell compartment reduces

272 ional host Tregs initially occupy a niche in lymphopenic transplantation recipients, undergo signific

273 VHD-like manifestations, we first examined B-lymphopenic uMT allo-BMT recipients and found that incre

274 el-1 T cells were transferred to B16-bearing lymphopenic versus lymphoreplete mice receiving alphaCD2

275 srupted lymphoid organs from GvHD and remain lymphopenic with a restricted TCR-Vbeta repertoire and r

276 Three patients were lymphopenic with low natural killer cell counts, but a s

277 Neonatal mice are lymphopenic within the first week of life.