ライフサイエンスコーパス: lymphopoiesis

1 in young mice phenocopied aging-associated B lymphopoiesis.

2 poiesis, granulopoiesis, erythropoiesis, and lymphopoiesis.

3 re important regulators of hematopoiesis and lymphopoiesis.

4 efect, skeletal abnormalities, and blocked B lymphopoiesis.

5 stromal microenvironment may improve thymic lymphopoiesis.

6 ization and lineage determination and B cell lymphopoiesis.

7 findings established a key role for CD11a in lymphopoiesis.

8 role for CXCR4 in orchestrating late B cell lymphopoiesis.

9 n of surface markers in normal and malignant lymphopoiesis.

10 heterochronic switch between fetal and adult lymphopoiesis.

11 tion, microRNAs are also being implicated in lymphopoiesis.

12 he S phase, for stem cell functions, and for lymphopoiesis.

13 ) attenuates the age-associated decline in T lymphopoiesis.

14 th age is thought to contribute to reduced T lymphopoiesis.

15 is essential for thymic organogenesis and T lymphopoiesis.

16 chemokines that play crucial roles in thymic lymphopoiesis.

17 ntribution of the mTOR complex I and II in T lymphopoiesis.

18 autonomous and Ink4a/arf-dependent effect on lymphopoiesis.

19 pocyte conditioned medium had no effect on B lymphopoiesis.

20 s multiple distinct defects in FL myelo- and lymphopoiesis.

21 are critical transcription factors in B-cell lymphopoiesis.

22 d a critical function of mTOR complex 2 in T lymphopoiesis.

23 effects of accelerated fat accumulation on B lymphopoiesis.

24 ature, likely accounting for their defective lymphopoiesis.

25 for understanding normal and dysregulated B lymphopoiesis.

26 ll homeostasis in adults in the absence of B lymphopoiesis.

27 g an in vitro requirement for periostin in B lymphopoiesis.

28 iesis, increased myelopoiesis, and decreased lymphopoiesis.

29 tively normally, but they display defects in lymphopoiesis.

30 t BM does not solely explain the arrest of B lymphopoiesis.

31 marrow emigrate into the spleen during adult lymphopoiesis.

32 that caused cell-intrinsic arrest of adult B lymphopoiesis.

33 e ability of bone marrow stroma to support B lymphopoiesis.

34 d bone marrow, indicating a possible role in lymphopoiesis.

35 ssor gene is induced in specific stages of B lymphopoiesis.

36 cells, has not yet been reported in human B lymphopoiesis.

37 rget of the transcription factor PU.1 during lymphopoiesis.

38 ion, we tested a role for Shc during early B lymphopoiesis.

39 erlapping and/or distinct functions during B lymphopoiesis.

40 stic changes, as well as profound defects in lymphopoiesis.

41 ect of constitutive JAK3 signaling on murine lymphopoiesis.

42 during fetal life but cannot sustain adult B lymphopoiesis.

43 logically relevant regulator of E2A during B lymphopoiesis.

44 n precursor T and B cells, markedly altering lymphopoiesis.

45 have been implicated in the regulation of B lymphopoiesis.

46 ls, suggesting a role of AHR in regulating B lymphopoiesis.

47 act through a different pathway, increased B lymphopoiesis.

48 es can be attributed directly to decreased B lymphopoiesis.

49 ctors, E12 and E47, that are essential for B lymphopoiesis.

50 B lymphocytes, despite evidence of normal B lymphopoiesis.

51 47, encoded by the E2A gene, is crucial to B lymphopoiesis.

52 tion factors that regulate de novo B-lineage lymphopoiesis.

53 of age absolutely requires IL-7Ralpha for B lymphopoiesis.

54 the transcriptional regulatory network of B lymphopoiesis.

55 stimulate cell differentiation during hemato/lymphopoiesis.

56 erarchical network of factors that control B lymphopoiesis.

57 witch region resulted in profound defects in lymphopoiesis.

58 imits the number of donor-derived HSCs and B lymphopoiesis.

59 regulatory elements for genes involved in T lymphopoiesis.

60 beta and S100A9, which negatively regulate B lymphopoiesis.

61 as murine HNF6 participates in fetal liver B lymphopoiesis.

62 ablishes a distinct role of CSF1R in fetal B-lymphopoiesis.

63 contribute to the age-associated decrease in lymphopoiesis.

64 cell receptor-alpha (TCRalpha) loci during B lymphopoiesis.

65 but largely unexplained roles in regulating lymphopoiesis.

66 downstream signaling components during early lymphopoiesis.

67 r events that regulate PTEN signaling during lymphopoiesis.

68 lymphoid progenitors (CLPs), which decreased lymphopoiesis.

69 ously been shown to have roles in regulating lymphopoiesis.

70 and various downstream pathways to regulate lymphopoiesis.

71 r of the family HNF1A in adult bone marrow B lymphopoiesis.

72 ocyte-derived factors are known to inhibit B lymphopoiesis.

73 ent B cells and favoring granulopoiesis over lymphopoiesis.

74 of global health significance, impairs human lymphopoiesis.

75 r hematopoietic stem cell (HSC) function and lymphopoiesis.

76 w myeloid cell LAL controls myelopoiesis and lymphopoiesis, a myeloid-specific doxycycline-inducible

77 In B lymphopoiesis, activation of the pre-B cell antigen rece

78 an differentially regulate early events in B lymphopoiesis, affecting entry and progression in distin

79 ant assays and examination of steady-state B lymphopoiesis also revealed that the expression of Notch

80 signaling, which is critical during normal B lymphopoiesis, also plays an important role in pre-BCR(+

81 5-phosphatase (SHIP) display a reduction in lymphopoiesis and a corresponding enhancement of myelopo

82 reased and was coupled with a reduction in B lymphopoiesis and compromised erythropoiesis, suggesting

83 actors are likely to have adverse effects on lymphopoiesis and contribute to leukemogenesis.

84 eta-analysis prediction that IL-18 affects T lymphopoiesis and demonstrated that IL-18 can positively

85 on's effects on central and extramedullary B lymphopoiesis and discuss the potential consequences of

86 nscription factor, which is known to inhibit lymphopoiesis and elevate myelopoiesis, and its expressi

87 sis cultures and found that they inhibited B lymphopoiesis and enhanced myelopoiesis.

88 ses loss of muscle mass and a reduction of B-lymphopoiesis and erythropoiesis, revealing their essent

89 haracterized rabbit BM after the arrest of B lymphopoiesis and found a dramatic increase in fat, incr

90 BCL11 genes play crucial roles in lymphopoiesis and have been associated with hematopoieti

91 Thus, Foxn1 affects both T lymphopoiesis and hematopoiesis, and the Foxn1 BM niche

92 ATM signaling is essential for lymphopoiesis and hematopoietic stem cell (HSC) function

93 nd this circuit is also operational during B lymphopoiesis and IL7 signaling.

94 1 encoding Ikaros, an essential regulator of lymphopoiesis and immune homeostasis, has been implicate

95 The omentum is a site of B1 cell lymphopoiesis and immune responsiveness to T cell-indepe

96 itical and nonredundant roles in both T cell lymphopoiesis and in maintaining and restoring periphera

97 These mice exhibited a reduction in T lymphopoiesis and in the production of marginal-zone B c

98 tion that is indispensable for normal B-cell lymphopoiesis and is mainly sustained by a subpopulation

99 approximately 92 and its functions during B lymphopoiesis and lung development.

100 LMBR1L has an essential function during lymphopoiesis and lymphoid activation, acting as a negat

101 Apoptosis plays a role in normal lymphopoiesis and lymphoid malignancies.

102 ate that the Gon4l protein is required for B lymphopoiesis and may function to regulate gene expressi

103 e NLRP3 inhibitor, glibenclamide, restored B lymphopoiesis and minimized induction of myeloid cells i

104 Leptin, which promotes lymphopoiesis and myelopoiesis, reached 100 ng/mL in ser

105 t an important role for leptin in sustaining lymphopoiesis and myelopoiesis.

106 ctly segregated in developing cells during B lymphopoiesis and peripheral mature B cells, respectivel

107 are transcriptional regulators important for lymphopoiesis and previously associated with hematopoiet

108 ALF) protein family previously implicated in lymphopoiesis and Purkinje cell function in the cerebell

109 in haematopoiesis that include a decline in lymphopoiesis and skewing towards the myeloid lineage.

110 ll-intrinsic transcription factor in adult B lymphopoiesis and suggest the IL-7R/STAT5 module to be c

111 to any HSC defects, may explain the reduced lymphopoiesis and sustained myelopoiesis that occur duri

112 that IL-18 can positively impact bone marrow lymphopoiesis and T cell development, presumably via int

113 L-7 completely prevents the stimulation of T lymphopoiesis and the bone loss that follow ovx.

114 LP) is a type 1 cytokine that contributes to lymphopoiesis and the development of asthma and atopic d

115 Restoration of Notch1 signaling rescued T lymphopoiesis and the marrow myeloid hyperplasia.

116 s regarding the effects of IL-7 and IL-15 on lymphopoiesis and their potential use for the treatment

117 pansion of multipotent progenitors, aberrant lymphopoiesis and thrombocytosis.

118 immune system, aging preferentially affects lymphopoiesis and thus results in the reduced competence

119 nscription factors are required for normal T lymphopoiesis and to prevent T-lymphocyte progenitor tra

120 specific embryonic tissues participate in B lymphopoiesis and whether hematopoietic differentiation

121 ase in interleukin-6 (IL-6), a decrease in B lymphopoiesis, and an elevation in myelopoiesis.

122 over a previously unknown role for DYRK1A in lymphopoiesis, and demonstrate how Cyclin D3 protein sta

123 e two fingers controlled different stages of lymphopoiesis, and finger 4 was selectively required for

124 This included restoration of lymphopoiesis, and HSC numbers and functions.

125 These data show a requirement for Ott1 in B lymphopoiesis, and inhibitory roles in the myeloid, mega

126 6(Ink4a) and Arf expression can rejuvenate B lymphopoiesis, and link aging and cancer resistance.

127 poiesis, granulocytopoiesis/monocytopoiesis, lymphopoiesis, and megakaryocytopoiesis.

128 uncover miR-142 as an essential regulator of lymphopoiesis, and suggest that lesions in this miRNA ge

129 t in strict separation into myelopoiesis and lymphopoiesis, and that there might be alternative pathw

130 secrete a soluble factor(s) that inhibits B lymphopoiesis, and we tested if this inhibition was due

131 We demonstrate that granulopoiesis and lymphopoiesis are coupled specifically in the bone marro

132 and T cell production and that reductions in lymphopoiesis are initiated much earlier than has genera

133 findings indicate that essential events in B lymphopoiesis are not tightly synchronized.

134 learn whether and how particular stages of B lymphopoiesis are responsive to these Wnt family ligands

135 B lymphopoiesis arrests in rabbits by 4 months of age.

136 B lymphopoiesis arrests precipitously in rabbits such that

137 and are important for pre-B and follicular B lymphopoiesis as demonstrated, respectively, by mb-1-Cre

138 ctivating subunit GABPbeta, is essential for lymphopoiesis as shown in our previous studies.

139 3a (Arid3a), a factor essential for FL and B lymphopoiesis, as a key transcriptional co-regulator of

140 , and showed profound reduction in BM B cell lymphopoiesis associated with damage to the endosteal BM

141 signaling function coordinately to regulate lymphopoiesis at a very early stage.

142 nd an adipocyte-derived factor that blocks B lymphopoiesis at the common lymphoid progenitor to prepr

143 Both proteins arrested B-lymphopoiesis at the pro-B to pre-B-cell transition and,

144 ary HCs from three distinct stages of B cell lymphopoiesis at the single cell level: HSPCs, common ly

145 , susceptibility to genetic lesions during B lymphopoiesis at the transition from the large pre-BII c

146 lineage extrinsically regulate bone marrow B lymphopoiesis, at least partially in an IL-7-dependent m

147 re independent of their inability to perform lymphopoiesis because a similar defect in hematopoietic

148 ggest that it was a site of combined T and B lymphopoiesis before evolving into an organ specialized

149 The process of lymphopoiesis begins in the bone marrow (BM) and require

150 B lymphopoiesis begins in the fetal liver, switching after

151 T lymphopoiesis begins with early T cell progenitors (ETP)

152 traordinary progress in defining stages of B lymphopoiesis between the hematopoietic stem cell and B

153 Here, we show the lymphopoiesis block in SHIP-/- mice is due to suppressio

154 in circulating red blood cells and sites of lymphopoiesis (bone marrow, thymus, and spleen).

155 ation named Justy was found that abolishes B lymphopoiesis but does not impair other major aspects of

156 SLP is closely related to IL-7 and active in lymphopoiesis, but an effect of TSLP on leukemia cells h

157 s of Ric-8A did not compromise bone marrow B lymphopoiesis, but splenic marginal zone B cell developm

158 absolutely essential for steady-state thymic lymphopoiesis, but the role of other Notch receptors, an

159 Unlike IL-1beta, which inhibits B lymphopoiesis by acting on early lymphoid progenitors, S

160 arly lymphoid progenitors, S100A9 inhibits B lymphopoiesis by acting on myeloid cells and promoting t

161 ble for lymphocyte trafficking yet restrains lymphopoiesis by activating the S1P1 receptor on bone ma

162 of the transcription factor network during B lymphopoiesis by up-regulating EBF, allowing stage trans

163 iven hard-wired pathway of emergency NK-cell lymphopoiesis bypassing steady-state gammac-signalling.

164 Finally, the defect in B lymphopoiesis can be rescued by transplantation into a W

165 he dramatic decline in the fitness of aged B-lymphopoiesis coincides with altered receptor-associated

166 Furthermore, defective lymphopoiesis correlated strongly with failure of hemato

167 ) myeloid cells, and recombinant S100A9 to B lymphopoiesis cultures and found that they inhibited B l

168 B lymphopoiesis declines with age, and in rabbits this occ

169 B lymphopoiesis declines with age, and this decline correl

170 The HNF1A(-/-) lymphopoiesis defect was confined to B cells as T lympho

171 se studies reveal a very early checkpoint in lymphopoiesis dependent on the combinatorial activities

172 Thymic lymphopoiesis depends on blood-borne, marrow-derived pro

173 These age-related changes in early B lymphopoiesis do not result from a general defect in HSC

174 Reduced lymphopoiesis during aging contributes to declines in im

175 contribute to the reductions seen in early B lymphopoiesis during murine senescence.

176 MEF2C therefore protects B lymphopoiesis during stress by ensuring proper expressio

177 -7 substitutions rescued the impairment of B lymphopoiesis exposed to DR.

178 o its oncogenic function in late stages of B lymphopoiesis, expression of IRF-4 is down-regulated in

179 pients, supporting a two-pathway model for B lymphopoiesis, fetal "B-1" and adult "B-2." Recently, Li

180 ation domain is required for E2A to rescue B lymphopoiesis from E2A(-/-) hemopoietic progenitors, alt

181 NK/T-cell progenitor during fetal and adult lymphopoiesis, further supporting that NK/T-lineage rest

182 o the B cell antigen receptor (pre-BCR) in B lymphopoiesis has not been elucidated.

183 The role of hedgehog (Hh) signaling in B lymphopoiesis has remained unclear.

184 Hedgehog (Hh) signaling promotes B lymphopoiesis in a non-cell-autonomous fashion in vitro,

185 e Hh pathway within stromal cells promotes B lymphopoiesis in a non-cell-autonomous fashion.

186 hen IL-7 stimulation is necessary in hemato-/lymphopoiesis in adult mice.

187 cursors linking extrathymic with intrathymic lymphopoiesis in adult mice.

188 ide therapeutic targets for restoration of B lymphopoiesis in aged and obese individuals.

189 ng nor the result of intrinsically altered B lymphopoiesis in aged BM, but instead appear to be gener

190 t inflammaging contributes to a decline of B lymphopoiesis in aged individuals, and furthermore, that

191 B lymphopoiesis in aged mice is characterized by reduced B

192 ans retinoic acid resulted in increased PreB lymphopoiesis in BM and an increase in thymic double-neg

193 Addition of anti-IL-1 Abs restored B lymphopoiesis in BM cultures containing MDSCs, showing t

194 itical determinant of T cell development and lymphopoiesis in general, most likely by acting as a tra

195 suppression as the cause of the defective B lymphopoiesis in Lig4 patients.

196 Early B lymphopoiesis in mammals is induced within the bone marr

197 y, and indicating a significant reduction in lymphopoiesis in ob/ob mice.

198 gene reconstituting normal embryogenesis and lymphopoiesis in the absence of the endogenous FADD.

199 Here, we addressed this question by studying lymphopoiesis in the absence of the Maml1 gene.

200 other species, however, including rabbits, B lymphopoiesis in the bone marrow abates early in life, a

201 There was a decrease in B lymphopoiesis in the bone marrow accompanied by a reduct

202 ased scaffold that mimics features of T cell lymphopoiesis in the bone marrow.

203 we showed that in mice, adipocytes inhibit B lymphopoiesis in vitro by inducing inflammatory myeloid

204 om mutant mice are defective in supporting B lymphopoiesis in vitro, whereas hematopoietic progenitor

205 to recapitulate the essential features of B lymphopoiesis in vitro.

206 teraction resulted in a marked decrease in B lymphopoiesis in vitro.

207 nd S1P, but not albumin-bound S1P, inhibited lymphopoiesis in vitro.

208 We conclude that efficient B lymphopoiesis in vivo is dependent on the maintenance of

209 ling in the osteoblastoid lineage promotes B lymphopoiesis in vivo.

210 s of this kind retained some potential for T lymphopoiesis in vivo.

211 embryonic erythropoiesis, myelopoiesis, and lymphopoiesis, including a 2- 3-fold increase in erythro

212 ilineage reconstitution that resembles fetal lymphopoiesis, including increased development of B-1a,

213 n of recombinant leptin promoted substantial lymphopoiesis, increasing the numbers of B cells in the

214 t was unclear whether Hoxa9 has functions in lymphopoiesis independent of, or alternatively, synergis

215 and inducible NO synthase did not restore B lymphopoiesis, indicating that inhibition is not mediate

216 y 50% the bone loss and the stimulation of T lymphopoiesis induced by ovx.

217 Human lymphopoiesis is a dynamic lifelong process that starts

218 ance of peripheral B cells in adults after B lymphopoiesis is arrested in BM.

219 in adult mice; however, its role in human B lymphopoiesis is controversial.

220 We propose that the age-related decline in B lymphopoiesis is due to a decrease in CFU-Fs, an increas

221 Here we show that B-cell lymphopoiesis is impaired in Treg-depleted mice, yet thi

222 Our results suggest that early B-cell lymphopoiesis is important for B-cell recovery following

223 re-TCR, the signaling pathway required for T lymphopoiesis is largely unknown.

224 In conclusion, when B lymphopoiesis is limited peripheral B-cell homeostasis i

225 ing MDSCs, showing that MDSC inhibition of B lymphopoiesis is mediated by IL-1.

226 Although lymphopoiesis is normal before disease onset, primary an

227 Together, these data indicate that B-1 lymphopoiesis is not sustained at constant levels throug

228 B lymphopoiesis is now seen as a gradual and unsynchronize

229 tial do not decline with age indicate that B lymphopoiesis is particularly sensitive to defects that

230 Treg-depleted mice, yet this reduced B-cell lymphopoiesis is rescued by adoptive transfer of affecte

231 sm underlying the regulation of early B cell lymphopoiesis is unclear.

232 although PU.1 initiates events leading to B lymphopoiesis, it might be dispensable at later stages o

233 gh NOTCH signaling is well known to regulate lymphopoiesis, Janus kinase 3 (JAK3) also plays a critic

234 provides a comprehensive analysis of human B lymphopoiesis, laying a foundation to apply this approac

235 ageing involves declining erythropoiesis and lymphopoiesis, leading to frequent anaemia and decreased

236 ns that at least some age-related changes in lymphopoiesis may be reversible.

237 e pathogenesis of leukemia in the context of lymphopoiesis may reveal novel therapeutic targets.

238 As a model of gene activation in early B lymphopoiesis, mb-1 genes are activated sequentially by

239 They suggest that T-cell lymphopoiesis might stall in individuals with short TL w

240 Under culture conditions that promoted B lymphopoiesis, mutant pre-pro-B cells remained alive and

241 By comparing fetal and adult B-lymphopoiesis, O'Byrne et al, in this issue of Blood, id

242 rphic mouse model, we found that B-1 and B-2 lymphopoiesis occurred in distinct fetal and adult waves

243 In contrast, B-2 lymphopoiesis occurred in distinct fetal and adult waves

244 inflammatory conditions, but redirection of lymphopoiesis occurred in TNFalpha-/- mice treated with

245 age, before sexual maturity, little to no B lymphopoiesis occurs in the bone marrow (BM).

246 Lymphopoiesis occurs throughout adult life, but the numb

247 Inflammation elicits a splenic lymphopoiesis of unknown physiologic significance but on

248 of L3MBTL1 did not result in deficiencies in lymphopoiesis or hematopoiesis.

249 d Foxn1 expression results in a decline in T lymphopoiesis, overexpression of Foxn1 in the thymus of

250 herefore, we hypothesized that IL-7-driven B lymphopoiesis plays a critical role in promoting Ab resp

251 Although dispensable during lymphopoiesis post lineage commitment, FADD plays a crit

252 (HSCs) was able to facilitate HSC-derived T-lymphopoiesis posttransplant.

253 Dysregulation of NuRD during lymphopoiesis promotes leukemogenesis.

254 paired in vitro, and the expression of the B lymphopoiesis-promoting transcription factors E2A, EBF1,

255 rrow chimera featured a dramatic defect in B lymphopoiesis recapitulating that of global HNF1A defici

256 During B lymphopoiesis, recombination of the locus encoding the i

257 immunophenotyping revealed up-regulation of lymphopoiesis-related genes and lymphoid cell-surface an

258 The stromal signals that promote B lymphopoiesis remain poorly understood.

259 igation in the later stages of bursal B cell lymphopoiesis remains elusive.

260 Although fetal B-lymphopoiesis remains poorly defined, it is key to under

261 ose that inflammation-induced extramedullary lymphopoiesis represents a specialized mechanism for inn

262 T lymphopoiesis requires settling of the thymus by bone ma

263 B lymphopoiesis requires that immunoglobulin genes be acce

264 8 has not previously been shown to promote T lymphopoiesis, results obtained via a novel data mining

265 lineage-, and stage-specific manner during B lymphopoiesis, serving either to facilitate or to impose

266 Therefore, in aged mice, B2 B lymphopoiesis shifts from dependency on pre-BCR expansio

267 s unclear in models of gut-associated B cell lymphopoiesis, such as that of the chicken (Gallus gallu

268 ion for the preferential effects of aging on lymphopoiesis, suggest that inhibiting p16(Ink4a) and Ar

269 In lymphopoiesis, T21 FL lymphoid-primed multipotential pro

270 In many mammals and birds, B cell lymphopoiesis takes place in GALT, such as the avian bur

271 Applied to human B cell lymphopoiesis, the algorithm (termed Wanderlust) constru

272 Thus, IL-7 receptor controls early B lymphopoiesis through activation of mTOR via PLCgamma/DA

273 vers a novel function for MDSCs to inhibit B lymphopoiesis through IL-1.

274 CH signaling exerts its biological effect on lymphopoiesis through modulating JAK3 levels.

275 thus suggesting that miR-132 may regulate B lymphopoiesis through Sox4.

276 lu)HSCs had a lineage-skewing potential from lymphopoiesis toward myelopoiesis, an increase in the lo

277 e cytokine IL-7 is important for controlling lymphopoiesis under both normal and lymphopenic conditio

278 ort demonstrates that age-related defects in lymphopoiesis underlie the myeloid dominance of adult le

279 ning an appropriate transcriptome in early B lymphopoiesis via chromatin accessibility.

280 show that RARgamma is a regulator of B and T lymphopoiesis via Nes-expressing cells in the BM and thy

281 dium experiments showed that MDSCs inhibit B lymphopoiesis via soluble factors, and by cytokine array

282 d, and spleen of adult rabbits, long after B lymphopoiesis was arrested.

283 lymphocytes-infiltrated bone marrow, B cell lymphopoiesis was blocked at pro-B to pre-B/immature B s

284 mpromised, but not erased, since transient B lymphopoiesis was detected in Rag-deficient recipients.

285 yeloid cells to levels in young animals, but lymphopoiesis was not rejuvenated, indicating that redun

286 antly improved and accelerated HSC-derived T-lymphopoiesis was observed.

287 opoiesis defect was confined to B cells as T lymphopoiesis was unaffected, and bone marrow common lym

288 The severe impact of dCK inactivation on lymphopoiesis was unexpected given that nucleoside salva

289 e whether the UPR plays an important role in lymphopoiesis, we carried out reconstitution of recombin

290 idate the functions of c-Jun in mouse thymic lymphopoiesis, we conditionally inactivated c-Jun specif

291 Confirming the role of OBs in B lymphopoiesis, we found that selective elimination of os

292 normal, but cells at subsequent stages of B lymphopoiesis were dramatically reduced in number.

293 f zebrafish Jak3 exerted a similar effect on lymphopoiesis, whereas ablation of zebrafish Stat5.1 and

294 Integrins contribute to lymphopoiesis, whereas Toll-like receptors (TLRs) facili

295 JAK3 plays a key role during early zebrafish lymphopoiesis, which can be potentially targeted to gene

296 Studies of the transcriptional regulation of lymphopoiesis will support the development of novel ther

297 monstrate a critical role for Shc in early B lymphopoiesis with a requirement in early B cell surviva

298 hibitory action of interleukin-6 (IL-6) on B lymphopoiesis with SHIP(-/-) mice and showed that IL-6 b

299 IP-Seq to characterize the microRNome during lymphopoiesis within the context of the transcriptome an

300 -2rgammac.b, substantially reduced embryonic lymphopoiesis without affecting other aspects of hematop