ライフサイエンスコーパス: lysin

1 , VERL, complexed with cognate sperm protein lysin.

2 ic peptide derived from staphylococcal delta-lysin.

3 ockets exposed with arrays of imidazoles and lysines.

4 ne domain, and 3) close to the ubiquitinated lysines.

5 by acetylation (neutralization) of multiple lysines.

6 hat control the ubiquitination state of ENaC lysines.

7 ys-C yields a diGly motif attached to target lysines.

8 the dichlorotriazine favored reactivity with lysines.

9 ng the solvent inaccessibility of the target lysines.

10 ed stable crosslink formation at telopeptide lysines.

11 ii) reductive methylation to dimethylate all lysines.

12 additionally requires contributions of other lysines.

13 y impeded by mutation of the automethylation lysines.

14 ation enzymes are autoneddylated at multiple lysines.

15 ith ubiquitin attachment sites mapped to six lysines.

16 by a mechanism dependent upon cytosolic GDU1 lysines.

17 ely; P < .01) with preferential glycation of lysines 107 and 557, sites involved in fibrin binding an

18 glutamine concentration, GS is acetylated at lysines 11 and 14, yielding a degron that is necessary a

19 ay crystallography, we found that acetylated lysines 115 and 122 in histone H3 are solvent accessible

20 Instead, we found that acetylation of lysines 115 and 122 increases the predisposition of nucl

21 volving arginines 102, 104, 106, and 107 and lysines 117 and 119.

22 uring neutrophil development, acetylation of lysines 121 and 198 were found to be crucial for termina

23 e simultaneous pseudo-acetylation of hTau at lysines 163, 280, 281 and 369 drastically decreased hTau

24 generation of Lin(Ub)n-Bcl10 requires Bcl10 lysines 17, 31, and 63, CARD11, MALT1, and the HOIP subu

25 ed and used to determine that acetylation of lysines 19 and 26 of MPC2 is enhanced in Akita heart mit

26 This determinant was also detected bound to lysines 195 and 475 of CLV-treated human serum albumin.

27 ith MAST1 blocked ubiquitination of MAST1 at lysines 317 and 545 by the E3 ubiquitin ligase CHIP and

28 further show that KDM4B is ubiquitinated on lysines 337 and 562; simultaneous substitution of these

29 tic stem and progenitor cells and a novel NK-lysin 4(+) cell type, representing a putative cytotoxic

30 ed T cells with a subsequent expansion of NK-lysin 4(+) cells and myeloid cells.

31 dy-state levels of methylation at histone H3 lysines 4 (H3K4me) and 36 (H3K36me) were sensitive to mu

32 Cotranscriptional methylation of histone H3 lysines 4 and 36 by Set1 and Set2, respectively, stimula

33 ng RA exposure, and we found that histone H3 lysines 4 and 9 are demethylated by the lysine-specific

34 hyltransferase with highest activity towards lysines 4 and 9.

35 IM5alpha internal lysines with Ub especially lysines 45 and 50, rather than modifying the N-terminal

36 We demonstrate that mutations in histone H4 lysines 5 and 12 in yeast confer hypersensitivity to rep

37 etylation of newly synthesized histone H4 at lysines 5 and 12 that accompanies replication-coupled ch

38 olein reacts with lysine residues, including lysines 5 and 12, sites important for chromatin assembly

39 etylation of newly synthesized histone H4 on lysines 5 and 12, which accompanies replication-coupled

40 atin during DNA replication is acetylated on lysines 5 and 12.

41 ythroid-derived 2-related factor 2 (NRF2) on lysines 506 and 508, leading to a reduction in total and

42 found that alpha-synuclein is acetylated on lysines 6 and 10 and that these residues are deacetylate

43 histones H3 and H4 undergo trimethylation at lysines 9 (H3K9), 27 (H3K27), 79 (H3K79), and 20 (H4K20)

44 genic enrichment of acetylated histone H3 at lysines 9 (H3K9ac) and 56 (H3K56ac), activation of cycli

45 rized by increased methylation of histone H3 lysines 9 and 27 (H3K9 and H3K27).

46 IES-associated chromatin is methylated on lysines 9 and 27 of histone H3, marking newly formed het

47 s are demethylases that target histone H3 on lysines 9 and 36 and histone H1.4 on lysine 26.

48 he Pcsk9 gene and deacetylates histone H3 at lysines 9 and 56, thereby suppressing the gene expressio

49 ethodology of studying E. coli cell lysis by Lysin A and its truncations after expressing these prote

50 nly one of these domains and the full-length Lysin A caused M. smegmatis cell lysis.

51 Our experiments establish that Lysin A harbors two catalytically active domains, both o

52 so demonstrate that the C-terminal domain of Lysin A selectively binds to M. tuberculosis and M. smeg

53 Several truncated versions of Lysin A were constructed, and their activities were anal

54 tion and regulation of mycobacteriophage D29 Lysin A.

55 Herein, we report the activity of aryl-alkyl-lysines against C. difficile and associated pathogens.

56 ys(1107), and the combined mutation of these lysines almost completely eliminated both the ubiquitina

57 llow leaf curl virus (TYLCV), with two other lysines also contributing to its nuclear import.

58 A mutant GCGR with all five intracellular lysines altered to arginines remains deubiquitinated and

59 We previously demonstrated that cNK-lysin and cNK-2, a synthetic peptide incorporating the c

60 trengths and, upon exocytosis into seawater, lysin and sp18 are dispersed to drive fertilization.

61 quantities of two rapidly evolving proteins, lysin and sp18, that are stored at nearly molar concentr

62 These rapidly adduct to protein lysines and are presented by dendritic cells as neoantig

63 We address this issue for lysines and arginines in designed transmembrane helices.

64 ositions due to the insertion of "anchoring" lysines and arginines into the DNA minor grooves.

65 The specific arrangement and number of the lysines and arginines of the PBD vary among the lipins.

66 pB), which differ in their selectivity after lysines and arginines, respectively, collectively accoun

67 mologs indicated conservation of a series of lysines and arginines, which could represent a nuclear l

68 ge of Phe-232 that is surrounded by pairs of lysines and arginines.

69 ther significant finding of the work is that lysines and cysteines in kinases may adopt neutral and c

70 element (IN2GHRE) histone methylation of key lysines and DNA methylation.

71 Here, we combined chemical modification of lysines and multiple-reaction monitoring mass spectromet

72 he bromodomain (BD), which recognizes acetyl-lysines and recruits proteins to sites of acetylation ac

73 o-glutamine (KQ) mutants to mimic acetylated lysines and screened 15 KQ mutants.

74 s are, with time, polyubiquitinated on other lysines and targeted to degradation.

75 d for rapid screening of engineered chimeric lysins and report a unique "chimeolysin", ClyR, with rob

76 ed that LOG2 ubiquitinates GDU1 at cytosolic lysines, and GDU1 protein levels decreased upon co-expre

77 er promising strategies, such as probiotics, lysins, and antimicrobial peptides, are in various stage

78 These results demonstrate that coumarin lysines are a new and valuable class of optical probes t

79 Lysines are acetylated in histone tails and the core dom

80 e asked if nucleophilic (reactive) catalytic lysines are common on the basis of the published crystal

81 w that in the bound structure, the conserved lysines are important for membrane binding, whereas the

82 Although lysines are known to be critical for ligand binding to L

83 rated two SMN mutants, SMN(K0), in which all lysines are mutated to arginines and thereby abolishing

84 By comparison, these lysines are not conserved in Xenopus laevis Ku, and Ku f

85 ns indicate that the roles of the individual lysines are not equivalent and that helical lysines play

86 ot induce IFN-gamma, arguing that the methyl lysines are part of the T cell epitope.

87 onjugating enzyme Ubc9, however the acceptor lysines are perfectly accessible in Ran/NTF2 complexes.

88 Our data indicate that internal lysines are the dominant Ub acceptor sites in both A3F a

89 Lysins are bacteriophage-derived enzymes that degrade ba

90 Autolysins and phage lysins are peptidoglycan hydrolases, enzymes that have e

91 Bacteriophage lysins are promising alternatives to antibiotics; howeve

92 ntrolled trials will determine if phages and lysins are safe and effective adjuncts or alternatives t

93 iotic resistance, phages and their products (lysins) are rediscovered as antibacterial bioagents.

94 Importantly, other reactive lysines as well as cysteines at various locations were a

95 oA dehydrogenase 9, two related enzymes with lysines at positions equivalent to Lys-318/Lys-322, were

96 rationalized by hydrophobic interactions of lysines at the bilayer interface.

97 sheet model of PrP(Sc), not only would these lysines be clustered within the 101-110 region of the pr

98 I) chains as a result of their C-telopeptide lysines being more completely oxidized to aldehydes.

99 en state to positively charged arginines and lysines between the intracellular ends of the voltage-se

100 erface, FITZAP coevolves rapidly to maintain lysin binding.

101 t by specific amino acids surrounding target lysines but that even optimal sequences require both Ada

102 For lysines (but not arginines) at two locations within diol

103 The acetylation of as few as three lysines by aspirin in A4V apo-SOD1-a variant that causes

104 ate that binding domains from autolysins and lysins can be fused to the Fc region of human IgG, creat

105 For substrates without Ltn1p-accessible lysines, CAT-tailing enabled degradation by exposing lys

106 A lack of APP C-terminal lysines caused APP redistribution from endosomal intralu

107 xymethyl)lysine (CML), N(euro)-(carboxyethyl)lysin (CEL), and methylglyoxal-derived hydroimadazolidin

108 Lysin CF-301 is being developed to treat Staphylococcus

109 Chicken NK-lysin (cNK-lysin), the chicken homologue of human granul

110 ion-binding residues and that the conserved lysines confer structural stability.

111 to posttranslational modifications of these lysines contributed to gB/gH-gL cell-cell fusion.

112 ons of gly-262 and thr-269 in Hsp90beta with lysines convert Hsp90beta to a Hsp90alpha-like protein.

113 Intriguingly, acetylation of several histone lysines correlated with the acetyl-CoA: (iso)butyryl-CoA

114 Escherichia coli, acetylation of proteins at lysines depends largely on a non-enzymatic acetyl phosph

115 , in this study, we investigated whether cNK-lysin derived peptides modulate the immune response in t

116 search on the in vivo behavior of phages and lysins, dialogues between researchers and regulatory age

117 WT pol mu, lacking homologous lysines, displayed nonspecific DNA binding behavior simi

118 Condensation with other allysines or lysines drives the formation of inter- and intramolecula

119 hat RasG ubiquitination occurs at C-terminal lysines equivalent to lysines found in human K-Ras but n

120 electron microcopy indicated that bovine NK-lysins exhibited their antimicrobial activities by lytic

121 The ability to lyse bacterial cells make lysins extremely significant.

122 predicted to insert a stretch of 13 or more lysines followed by either an in-frame insertion of a re

123 tion results from pausing on consecutive AAA-lysines followed by ribosome sliding on homopolymeric A

124 n act as a signal at five cytodomain-located lysines for endosomal sorting of APP.

125 DAIP contains 5 potential glutamines and 10 lysines for MTG-mediated cross-linking.

126 ubstrate-binding domain to prioritize target lysines for ubiquitination.

127 Additionally, those lysines for which the SETA reactivity increased under de

128 f the heavy and light chains and susceptible lysines), forming either hemiaminal (+148 Da) or Schiff

129 n occurs at C-terminal lysines equivalent to lysines found in human K-Ras but not in H-Ras and N-Ras

130 n clots by removing C-terminal arginines and lysines from partially degraded fibrin.

131 increased with considerable variation among lysines from the same protein.

132 site core, whereas the two other active site lysines from the two other domains are not able to move.

133 In summary, the single NK-lysin gene in other mammals has expanded to a four-membe

134 rovide evidence for the existence of four NK-lysin genes in a repetitive region on cattle chromosome

135 iptional modifications (marks) to histone H3 lysines (H3K4me3, H3K4me1, H3K27ac, H3K27me3, and H3K36m

136 nine substitutions at other known methylated lysines (H3K9 and H3K36) are sufficient to cause specifi

137 Aryl-alkyl-lysines have been earlier reported to possess antimicrob

138 ctions in affinity have been found when such lysines have been mutated.

139 ter the binding of FH19-20 to proteins where lysines have reacted with malondialdehyde (MDA).

140 orating the core alpha-helical region of cNK-lysin, have antimicrobial activity against apicomplexan

141 tn1p efficiently accessed only nascent-chain lysines immediately proximal to the ribosome exit tunnel

142 ctrometry analysis, identifying 4 acetylated lysines in 3 distinct functional domains.

143 ly studies showed that sirtuins deacetylated lysines in a reaction that consumes NAD(+), more recent

144 We identify over a thousand sumoylated lysines in a total of 468 proteins and quantify changes

145 lization, as previously shown for acetylated lysines in H3 histone tails.

146 While acetylated lysines in histone tails are frequently recognized by ot

147 acyl groups from the epsilon-amino group of lysines in histones and other substrate proteins.

148 Ubiquitination of lysines in Hrd1's RING-finger domain is required for sub

149 e have quantified, in total, more than 9,000 lysines in human cell proteomes and have identified seve

150 ity, and robust activity was also reliant on lysines in Ku70 analogous to K31 and K160.

151 ent sorting is essential for modification of lysines in multiple collagen types.

152 t NeuCode SILAC partners enables counting of lysines in product ions, and when the information is use

153 re reversibly installed at the side chain of lysines in proteins.

154 terminus and two conserved phosphate-binding lysines in the beta-arrestin2 N-domain.

155 Thus, Pro-102 and Pro-105, as well as the lysines in the central lysine cluster, impede amyloid fo

156 mediated acetylation on two conserved tandem lysines in the cohesin Smc3 subunit.

157 revealed that a highly conserved cluster of lysines in the gamma-ENaC N terminus regulates accessibi

158 /SNF and RSC, acetylation of lateral surface lysines in the histone octamer serves as a crucial regul

159 leosomes containing acetylated or methylated lysines in the histone tails of H3 and H4 present in the

160 These data suggest that the three lysines in the lyase active site destabilize pol beta wh

161 vealed that ADA and Piccolo NuA4 crotonylate lysines in the N-terminal tails of histone H3 and H4, re

162 lustered in the N-terminal region but not at lysines in the oligomerization, intramembrane, or C-term

163 iquitin-like modifier) by mutating conserved lysines in the polyQ AR that are sites of SUMOylation.

164 rporation and conservation of arginines over lysines in these motifs.

165 Mutating a cluster of five lysines in this region largely eliminates Yku70 sumoylat

166 Attachment of SUMO moieties to internal lysines in Ubc9 itself can further lead to the formation

167 Mutation of the two succinylated lysines in UCP1 to acyl-mimetic glutamine and glutamic a

168 aradoxically, acetylation of p53 at the same lysines in various cancer cell lines leads to the induct

169 relates with acetylation of specific histone lysines in WAT but not in the liver.

170 Lysines in wild-type- and ALS-variant apo-SOD1 could als

171 (LLP) motifs and are scarcely substituted by lysines, in contrast to gp120 and the ectodomain of gp41

172 dules, condense the search radius for target lysines, increase the chance of active-site collision wi

173 Methylation of these lysines increases PRC2 histone methyltransferase activit

174 We designed polyglutamines with a few lysines inserted to overcome the hindrance of extreme in

175 FITZAP-lysin interactions exhibit a similar species-specificity

176 NK-lysin is an antimicrobial peptide and effector protein i

177 ted covalent modification of surface-exposed lysines is challenging due to their low intrinsic reacti

178 and that an interaction(s) mediated by these lysines is essential for B. burgdorferi murine infection

179 Post-translational acetylation of lysines is most extensively studied in histones, but thi

180 The reversible acetylation of lysines is one of the best characterized epigenetic modi

181 ebacase, a first-in-class antistaphylococcal lysin, is a direct lytic agent that is rapidly bacteriol

182 rated two OAT1 mutants, each having multiple lysines (K) simultaneously mutated to arginine (R).

183 acetylating newly synthesized histone H4 on lysines K5 and K12.

184 an Dvl2 DIX domain mono-ubiquitinated at two lysines (K54 and K58) by genetically encoded orthogonal

185 Lysines K82, K163, and K170 of DbpA are known to be impo

186 Taken together, these data showed that lysines K82, K163, and K170 potentiate the binding of Db

187 sure of Arabidopsis increases acetylation of lysines K9 and/or K14 of histone H3 at UVR8-regulated ge

188 labels [1-(13)C]glycine and L-[epsilon-(15)N]lysin, L-[1-(13)C]lysine and D-[(15)N]alanine, or D-[1-(

189 different generations of dendrigraft poly-L-lysines leading to quantitative information (i.e., stoic

190 We here show that mutating these lysines leads to nuclear exclusion of TYLCV Rep without

191 mia, is a homotetramer with multiple surface lysines, limiting conventional approaches for albuminati

192 e substitution at each of a cluster of three lysines (Lys-42, Lys-43, and Lys-135) renders FLNa resis

193 The positive charge on two of these lysines, Lys(49) and Lys(120), is critical for coordinat

194 mediate Gap1 ubiquitylation of two possible lysines, Lys-9 and Lys-16, the Aly proteins promote ubiq

195 When this site is unavailable, three nearby lysines may become ubiquitinated.

196 P accumulation, ubiquitination of cytodomain lysines may represent a key signal controlling APP endos

197 The lysines modified by DOB are often post-translationally m

198 contains an N-terminal carbohydrate-binding lysin motif (LysM) domain and a C-terminal domain of unk

199 characterized by the presence of one or more lysin motif (LysM) domains in the extracytoplasmic porti

200 OXR1 contains the Tre2/Bub2/Cdc16 (TBC), lysin motif (LysM), domain catalytic (TLDc) domain, a mo

201 s nodulation receptor-like kinase (NORK) and lysin motif domain-containing receptor-like kinase 3 (LY

202 of a Tre2/Bub2/Cdc16 (TBC) domain and a TBC/lysin motif domain/catalytic (TLDc) domain.

203 cular pattern recognized in Arabidopsis by a lysin motif receptor kinase (LYK), AtCERK1.

204 ular patterns (MAMPs) that are recognized by LYSIN MOTIF RECEPTOR KINASE5 (LYK5), inducing the format

205 or receptors NOD FACTOR PERCEPTION (NFP) and LYSIN MOTIF RECEPTOR-LIKE KINASE3 (LYK3) in establishing

206 ocess, and it is not known whether the plant lysin-motif receptor-like kinase MtLYK10 intervenes in r

207 Plant -specific lysin-motif receptor-like kinases (LysM-RLKs) are implic

208 perception activates symbiosis signaling via Lysin-motif RLKs and subsequently the common symbiosis s

209 nhibited catalytic activity and labeled four lysines; mutagenesis demonstrated that two of these, Lys

210 f geometrical motifs featuring histidines or lysines near tyrosines, facilitating histidine and lysin

211 Mutation of six C-terminal lysines of DCP1a suppresses decapping activity and impai

212 onstant pH molecular dynamics, the catalytic lysines of eight unique kinases from various human kinas

213 enetic readers that interact with acetylated lysines of histone tails.

214 fer of this fluorophore from IgG to specific lysines of its binding partner SpA but not to bovine ser

215 Mutating several lysines of the gamma2IL into arginines makes the gamma2

216 These ligases transfer ubiquitin to lysines of the ligands' intracellular domains (ICDs), wh

217 sin is promoted by acetylation of N-terminal lysines of the Smc3 subunit by the acetyltransferases Ec

218 cogenides (COCs), are covalently attached to lysines of wild-type streptavidin.

219 ations as acetylmimetics to map the relevant lysines on actin for INF2 regulation, focusing on K50, K

220 own by increased acetylation at SIRT6 target lysines on histone 3, reduced TNF-alpha secretion, GLUT-

221 omain family of proteins binds to acetylated lysines on histones and regulates gene transcription.

222 bly transferred ubiquitin to surface exposed lysines on target proteins and even catalyzed the format

223 modomains that mediate binding to acetylated lysines on target proteins to regulate gene expression.

224 ivates UHRF1 ubiquitylation towards multiple lysines on the H3 tail adjacent to the UHRF1 histone-bin

225 dependent deacetylation of N(epsilon)-acetyl lysines on various protein substrates.

226 on to block the methylation of corresponding lysines on wild type histones.

227 ected functionalization at introduced unique lysines or cysteines facilitate many applications.

228 has been dominated by random modification of lysines or more site-specific labeling of cysteines, eac

229 Mutation of lysines or p300 inhibitor treatment causes the loss of e

230 he arginines with alanines or more conserved lysines or replacement of isoleucine with alanine or val

231 sfolding of PM proteins likely exposes these lysines or shifts them into the "ubiquitination zone" ac

232 repeat of the four amino acids preceding the lysines, or a frameshift.

233 lysines are not equivalent and that helical lysines play a more prominent role in determining bindin

234 be required for the attachment of the phage lysin PlyG with the bacterial envelope and for bacterial

235 of the isotope peaks indicates the number of lysines present in the protein, information that aids in

236 Of interest, mutating any one of the three lysines prevented the ubiquitin conjugation to the other

237 ge-neutralizing substitutions of four nearby lysines promoted spontaneous prion formation.

238 the discovery of a peptide containing methyl lysines recognized by a mAb that binds to native HBHA ~1

239 blocks the functional readout of acetylated lysines, reduced heroin self-administration and cue-indu

240 poly-A tail, encoding for positively charged lysines regardless of the reading frame, would act as a

241 analyses show that yku70 mutants with these lysines replaced by arginines exhibit reduced Ku-DNA ass

242 ically label the side chains of cysteines or lysines, respectively, in native proteins.

243 CAT-tailing enabled degradation by exposing lysines sequestered in the ribosome exit tunnel.

244 cross-linking, N-homocysteinylation of these lysines should impair cross-linking.

245 istone 4 residues neighboring the acetylated lysines significantly influenced binding.

246 es, we found that AtPRORP1 exploits specific lysines strategically positioned at the tips of it's V-s

247 d the ubiquitin conjugation to the other two lysines, suggesting that Lys297, Lys303, and Lys315 may

248 or sites, and variable combinations of these lysines support both full transcriptional activity and v

249 Substrate lysines targeted for ubiquitination are also often locat

250 hat an increase in the number of substituted lysines tends to increase APP metabolism.

251 ClyR is the first lysin that demonstrates activity against the dominant de

252 caries-causing pathogen as well as the first lysin that kills all four of the bovine mastitis-causing

253 we identify a large set of mostly unexplored lysines that are potentially targetable with covalent in

254 lation assay, we identified highly conserved lysines that are targeted by p300 for acetylation.

255 ults in the formation of spatially clustered lysines that could serve as recognition patches for bind

256 ectively transferred between amino groups of lysines that reside within ~10 A at the protein-protein

257 Upon infection, mycobacteriophages produce lysins that catalyze cell wall peptidoglycan hydrolysis

258 he phage genome encodes toxic genes, such as lysins, that kill the bacterium during the phage infecti

259 DJ-1 deglycates cysteines, arginines, and lysines (the three major glycated amino acids) of serum

260 Chicken NK-lysin (cNK-lysin), the chicken homologue of human granulysin, is a

261 ompared to traditional NHS ester-labeling of lysines, the cysteine-maleimide strategy resulted in far

262 1 ubiquitination, we converted each of these lysines to arginine and found that replacing two of thes

263 h the RRS1 WRKY domain, and PopP2 acetylates lysines to block DNA binding.

264 ploit Schiff imine formation via the exposed lysines to efficiently hydrolyze both activated and inac

265 Mutagenesis of these lysines to leucines abolished protein disulfide isomeras

266 hindrance of extreme insolubility and two D-lysines to limit the lengths of beta-strands.

267 DNA-sensing lysines trigger ATP hydrolysis to open the SMC head inte

268 epressor Tup1 is sumoylated, at two specific lysines, under various stress conditions.

269 An APP mutant lacking all C-terminal lysines underwent the most pronounced increase in proces

270 NMR analyses revealed that lysin uses a common molecular interface to bind both FIT

271 ons exhibit a similar species-specificity as lysin-VERL interactions.

272 As sexual selection alters the lysin-VERL interface, FITZAP coevolves rapidly to mainta

273 Overall, the findings suggest aryl-alkyl-lysines warrant further investigation as novel agents to

274 Dimethylation of lysines was achieved quantitatively and specifically wit

275 The effect on cross-linking lysines was quantitatively very similar to that previous

276 When positive charges of lysines were eliminated by acetic anhydride instead of M

277 Controls where lysines were mutated with charged residues accessed simi

278 The genetically encoded coumarin lysines were successfully applied as fluorescent cellula

279 Remarkably, both lysins were able to lyse only Gram-positive bacterial st

280 riaminepentaacetic acid (p-SCN-DTPA) via the lysines, whereas JVZ-007-cys was conjugated to maleimide

281 domain is ubiquitinated in vivo at multiple lysines, which can be antagonized by various deubiquitin

282 ly 168 polypeptides contained early glycated lysines, which did not resemble the sites of advanced gl

283 the screening method resulting in a powerful lysin with potential for treating most streptococcal ass

284 lecule, they are directly labeled on surface lysines with a biotinylated derivative of the small ubiq

285 we show that substitution of APP C-terminal lysines with arginine disrupts APP ubiquitination and th

286 -labeled acetyl groups onto specific histone lysines with quantitative mass spectrometry.

287 Ube2W targets multiple TRIM5alpha internal lysines with Ub especially lysines 45 and 50, rather tha

288 pulsion between four closely spaced cationic lysines within a central lysine cluster of residues 101-

289 h4-Rsp5 can target and ubiquitinate multiple lysines within a restricted distance from the membrane,

290 catalytic module to drive ubiquitination of lysines within an accessible zone.

291 ditional mutation of Ku70 K160 and six other lysines within Ku80 were required to eliminate all activ

292 As there are three lysines within Nt(17), we evaluated the impact of lysine

293 We show here that lysines within the 14-3-3zeta binding pocket and protein

294 Acetylation occurs at eight lysines within the C-terminal domain (CTD) of the larges

295 Lysines within the lyase domain are required for process

296 Acetylation of selected lysines within the NID activates DNA binding.

297 structures dependent upon the TREX1 CTR and lysines within the TREX1 catalytic core.

298 monstrate that Gcn5p acetylation of separate lysines within the zinc cluster domain negatively impact

299 Ubiquitylation of lysines within this site leads to rapid proteasomal degr

300 critical for their interaction and multiple lysines within TPP1 that are oligo-ubiquitinated and deu