ライフサイエンスコーパス: lysine

1 e SETD3 target specificity from histidine to lysine.

2 ly controlled by acylation of an active-site lysine.

3 ls when compared to poly-l-lysine and poly-d-lysine.

4 nteraction network surrounding the catalytic lysine.

5 iciency (k (cat)/K(m) ) on histidine than on lysine.

6 y kidney is reduced by coadministration of l-lysine.

7 loped a covalent docking approach focused on lysine.

8 xyl in beta-tyrosine and N-Boc protection in lysine.

9 ockets exposed with arrays of imidazoles and lysines.

10 Among the candidates, we characterized lysine 112 of the actin regulator cofilin as a novel ned

11 e find that heterozygous loss of histone H2A lysine 119 deubiquitinase BAP1 (BRCA1 Associated Protein

12 es catalyze removal of monoubiquitination on lysine 119 of histone H2A (H2AK119ub1) through a multipr

13 168 catalyzes H2A and H2AX ubiquitination on lysine 13/15 (K13/K15) upon DNA damage and promotes the

14 GCN5 was previously shown to acetylate lysine 14 of histone 3 (H3K14ac) in the promoter regions

15 tylated by the acetyltransferase p300/CBP on lysine 152, the key residue that when polyubiquitinated

16 YST family of HATs, acetylates histone H4 at lysine 16 (H4K16ac).

17 Here, we show that histone H4 lysine 16 acetylation (H4K16ac) is maintained from oocyt

18 f lysine deacetylase Hst2 and the removal of lysine 16 acetylation in histone 4.

19 n chickens, we determined that the invariant lysine 170 (K170) of MDV CHPK is required for interindiv

20 acetylated histone 3 lysine 27 and histone 3 lysine 18) flanking the ATF3 promoter region.

21 sibility by direct acetylation of histone H3 lysine-18 (H3K18).

22 ependymomas contain the recurrent histone H3 lysine 27 (H3 K27M) mutation and express the H3 K27M-mim

23 Methylation of histone H3 lysine 27 (H3K27) is widely recognized as a transcriptio

24 ic protein complex that catalyzes histone H3 lysine 27 (H3K27) methylation to mediate epigenetic sile

25 Histone H3 lysine 27 (H3K27M) mutations represent the canonical onc

26 ription through trimethylation of histone H3 lysine 27 (H3K27me3) and has emerged as an important the

27 asis through trimethylation of histone H3 at lysine 27 (H3K27me3) at their promoters.

28 Trimethylated histone H3 lysine 27 (H3K27me3) regulates gene repression, cell-fat

29 ation caused widespread changes in histone 3 lysine 27 acetylation (H3K27ac), and was associated with

30 that the majority do not acquire histone H3 lysine 27 acetylation and no longer interact with their

31 ize with BRD4L, MED1 and sites of histone H3 lysine 27 acetylation.

32 istone lysine residues (acetylated histone 3 lysine 27 and histone 3 lysine 18) flanking the ATF3 pro

33 at pharmacologic inhibition of the histone 3 lysine 27 demethylases KDM6A (UTX) and KDM6B (JMJD3) lea

34 2 modifies their chromatin by trimethylating lysine 27 on histone H3 (H3K27me3).

35 ors in pluripotent stem cells by methylating lysine 27 on histone H3.

36 und that genome-wide promotion of histone H3 lysine 27 trimethylation (H3K27me3) enables nitrogen-ind

37 agues show that histone H3 trimethylation on lysine 27, induced by polycomb repressive complex 2 (PRC

38 expression through methylation of histone 3 lysine 27, was essential for repression of numerous gene

39 By performing H3-lysine-27 acetylation (H3K27ac) ChIP-seq in Enz-resistan

40 histone modifications, especially histone H3 lysine-27 dimethylation (H3K27me2), in genome evolution

41 one H3 lysine-9 di-methylation (H3K9me2) and lysine-27 tri-methylation (H3K27me3) are linked to repre

42 ely regulates FOXA1 binding by demethylating lysine 270, adjacent to the wing2 region of the FOXA1 DN

43 he core of a CBD filament comprises residues lysine 274 to glutamate 380 of tau, spanning the last re

44 ed nuclear factor-kappaB RELA methylation at lysine 310 and associated increases in H3K9me2 (histone

45 dy, we discovered that FUS was acetylated at lysine-315/316 (K315/K316) and lysine-510 (K510) residue

46 PAC is determined by the positively charged lysine 319 residue on TM2, and replacing lysine 319 with

47 ged lysine 319 residue on TM2, and replacing lysine 319 with a glutamate residue converts PAC to a ca

48 racted with PHGDH and ubiquitinated PHGDH at lysine 330, leading to PHGDH degradation to suppress ser

49 c marks such as trimethylation of histone H3 lysine 36 (H3K36me3) and DNA methylation play a role in

50 ly catalyzes tri-methylation of lysine 4 and lysine 36 of Histone H3 in nearby nucleosomes.

51 chymal stem cells by impeding methylation at lysine 36 on histone H3 (H3K36) by SETD2, but not by the

52 s of lysine residues 290 and 294 from R2 and lysine 370 from the sequence after R4.

53 Methylation of histone H3 lysine 4 (H3K4) by Set1/COMPASS occurs co-transcriptiona

54 Histone 3 Lysine 4 (H3K4) demethylation is ubiquitous in organisms

55 ring cell-fate change(5), whereas histone H3 lysine 4 (H3K4) trimethylation marks active gene promote

56 M9 subsequently catalyzes tri-methylation of lysine 4 and lysine 36 of Histone H3 in nearby nucleosom

57 tylation (H3K9ac and H3K27ac) and histone H3 lysine 4 methylation (H3K4me) during activation; while d

58 the TrxG - the COMPASS family of histone H3 lysine 4 methyltransferases and the SWI/SNF family of ch

59 ve chromatin mark H3K4me3 (trimethylation of lysine 4 on histone H3), indicative of in vivo training.

60 which were correlated with strong histone H3 lysine 4 trimethylation (H3K4me3) and CCCTC-binding fact

61 Set5 is a histone H4 lysine 5, 8, and 12 methyltransferase, implicated in the

62 etylation of newly synthesized histone H4 on lysines 5 and 12, which accompanies replication-coupled

63 acetylated at lysine-315/316 (K315/K316) and lysine-510 (K510) residues in two distinct domains.

64 OTUD3 directly hydrolyzes lysine 63 (Lys63)-linked polyubiquitination of MAVS and

65 ctivation requires its monoubiquitination on lysine 644 (K644) within the Ig3 domain, localized adjac

66 Upon binding, SIRT7 deacetylates PCAF at lysine 720 (K720), which augments PCAF binding to murine

67 DOT1L methylates lysine 79 in the globular domain of histone H3 (H3K79).

68 M) and resulting in loss of dimethylation at lysine 79 of histone H3 (H3K79me2).

69 ts in aberrant hypermethylation of histone 3 lysine 9 (H3K9) at loci surrounding DNA breaks, masking

70 translate into activation of the histone H3 lysine 9 (H3K9) methyltransferase Ehmt1 and stabilizatio

71 Histone H3 lysine 9 (H3K9) trimethylation is associated with hetero

72 Conversely, the euchromatin mark histone 3 lysine 9 acetylation (H3K9ac) is abundant in non-heteroc

73 Targeting SIRT1 by RNAi led to elevated H3 lysine 9 acetylation on the promoter region of miR-1185-

74 There are rhythms in histone H3 lysine 9 and 27 acetylation (H3K9ac and H3K27ac) and his

75 associated increases in H3K9me2 (histone H3 lysine 9 dimethylation) in the dorsal hippocampus and th

76 activation; while deacetylation, histone H3 lysine 9 methylation (H3K9me) and heterochromatin protei

77 OL2A inhibits DNA methylation and histone H3 lysine 9 methylation.

78 ls, histone deacetylases (HDACs), histone H3 lysine 9 methyltransferase (KMT1/SUV39), and components

79 omatin is characterized by trimethylation of lysine 9 on histone H3, hypoacetylation of histones, and

80 Histone H3 lysine-9 di-methylation (H3K9me2) and lysine-27 tri-meth

81 enomic RNA, and transcription via histone H3 lysine-9 dimethylation.

82 Lysine acetylation (Kac), an abundant post-translational

83 e deacetylase 1 binding, increased histone 4 lysine acetylation and subsequent BRD4-driven transcript

84 identify K(100) and K(188) as major sites of lysine acetylation in the NAT1 protein.

85 Lysine acetylation is a key mechanism of post-translatio

86 Lysine acetylation is a posttranslational modification t

87 caused dynamic changes in the global histone lysine acetylation levels (H3K4ac, H3K9/K14ac and H3K27a

88 t study investigated whether GCN5L1-mediated lysine acetylation regulates cardiac mitochondrial metab

89 Mitochondrial lysine acetylation regulates several metabolic pathways

90 ecently, it was reported that NAT1 undergoes lysine acetylation, an important post-translational modi

91 We show that the lysine acetyltransferase Tip60 acetylates eEF1A1, wherea

92 KAT5 encodes an essential lysine acetyltransferase, previously called TIP60, which

93 es into off-pathway states incompatible with lysine adenylylation.

94 Herein, we report the activity of aryl-alkyl-lysines against C. difficile and associated pathogens.

95 njugation more often with cysteine thiols or lysine amines.

96 available small-molecule inhibitors, such as lysine analogs, bind unselectively to kringle domains an

97 to catalyze methylation of slightly bulkier lysine analogs, but lack the activity for analogs that p

98 e SPIN1 interface previously shown to bind a lysine and arginine methylated sequence of histone H3.

99 Either supplementation of the media with lysine and arginine or suboptimal temperature appears to

100 helix 8 burial in the inner leaflet, ordered lysine and arginine side chains in the membrane interfac

101 ubular reuptake of glycation free adducts by lysine and arginine transporter proteins in patients wit

102 h cuts specifically after the basic residues lysine and arginine, is the predominant enzyme used for

103 Remarkably, fractional excretions of 6 lysine and arginine-derived glycation free adducts were

104 lective bioconjugation of cytotoxic drugs to lysine and cysteine residues.

105 y based on reorganization of a non-conserved lysine and displacement of an additional structured wate

106 from 0.611 and 0.520 to 0.655 and 0.566 for lysine and from 0.723 and 0.640 to 0.734 and 0.643 for a

107 ng evidence that NMT acts both as N-terminal-lysine and glycine myristoyltransferase.

108 und to be similar in GB to basic amino acids lysine and histidine, and phosphatidic acid and phosphat

109 over mammalian cells when compared to poly-l-lysine and poly-d-lysine.

110 t different cysteines, and acyl adducts with lysine and several tyrosine residues.

111 d all the essential amino acids (EAA) except lysine and threonine, as required by pre-school children

112 nd di-N-arylation of amino acid derivatives (lysine and tryptophan) under very mild conditions.

113 complex is negatively regulated by arginine, lysine, and histidine, the amino acids that PQLC2 transp

114 ylate and acrylic acid, with mussel-inspired lysine- and aromatic-rich monomers.

115 jor amino acid profile composition-arginine, lysine, aspartic acid, alanine, threonine and low levels

116 Specifically, when yeast lysine-auxotrophic mutant lys- encountered lysine limita

117 Two series of ligands targeting the lysine binding sites have been recently described, which

118 s achieved through a hydrophobic trimethyl-L-lysine-binding 'cage' formed by BAHCC1(BAH), mediating c

119 ein, we use intact proteins to show that the lysine-binding site of K2(hPg) is a major determinant of

120 hat a small-molecule inhibitor targeting the lysine-binding site of KIV-10 can combat the pathophysio

121 d have been proposed to be mediated by their lysine-binding sites.

122 kinase with activating mutations and a caged lysine blocking the active site, we can rapidly switch o

123 'EK(S)K(S) (K(S) = S-aroylthiooxime-modified lysine, C' = citrulline, and E = glutamic acid).

124 The amine group of lysine can accept up to three methyl groups, and experim

125 with polyinosinic-polycytidylic acid-poly-I-lysine carboxymethylcellulose (poly-ICLC) every 3 weeks

126 Despite intensive study, plant lysine catabolism beyond the 2-oxoadipate (2OA) intermed

127 thaliana HglS homolog coexpresses with known lysine catabolism enzymes, and mutants show phenotypes c

128 the ALDH7A1 gene leading to blockade of the lysine catabolism pathway.

129 ts show phenotypes consistent with disrupted lysine catabolism.

130 NPs), and stabilized with a shell of poly(l-lysine) cationic polymer (PLL) for simultaneous synergis

131 Although the K398A mutation in the lysine cluster blocks PIP(2) binding, this mutated prote

132 In addition to a conserved PIP(2)-selective lysine cluster, a larger cationic surface surrounding th

133 oncentrations of the major AGE carboxymethyl-lysine (CML) and the soluble receptor for AGEs (sRAGE) i

134 tty acyl modifications such as myristoylated lysine compared with acetylated counterparts, but the de

135 Lysine complexation inside the tweezer cavity is needed

136 m water and for the selective recognition of lysine-containing peptides, opening new perspectives in

137 Mutation of o2 doubles maize endosperm lysine content, but it causes an inferior kernel phenoty

138 Lysine crotonylation (Kcr) is a histone post-translation

139 Herein, we probed the recognition of lysine crotonylation and acetylation by the AF9 YEATS do

140 (H3S10ph), which signals the recruitment of lysine deacetylase Hst2 and the removal of lysine 16 ace

141 rimental data on the response of the protein lysine deacetylase SIRT1 to small-molecule activators.

142 Eleven metal-dependent lysine deacetylases (KDACs) have been identified in huma

143 we investigated the mechanisms of activated lysine deacetylation and enhanced long-chain acyl-group

144 ffering the acetyl group pool and catalyzing lysine deacetylation, respectively-was developed to mode

145 aciduria type 1 (GA1) is an inborn error of lysine degradation characterized by a specific encephalo

146 athy that is caused by toxic accumulation of lysine degradation intermediates.

147 erived from glutaryl-CoA, an intermediate in lysine degradation.

148 hat oncometabolite-induced inhibition of the lysine demethylase KDM4B results in aberrant hypermethyl

149 all interfering RNAs (siRNAs) and histone H3 lysine dimethylation (H3K9me2), without gaining CHH meth

150 y 100 fold greater viscosity than comparable lysine droplets, both of which can be finer tuned by pol

151 ayers of short alternating glutamic acid and lysine (EK) peptides as a facile, highly effective and l

152 An example of AMP is Epsilon-Poly-L-lysine (EPL), a polypeptide formed by ~ 25 lysine residu

153 xplored further by using bacteria-friendly l-lysine-functionalized cerium oxide nanoparticle coated i

154 Moreover, introduction of lysine, glutamine or proline at residue A578 also elicit

155 Our findings also reveal that lysine glycation appears to be an important factor that

156 However, the levels of lysine glycation in collagen, which is not considered a

157 tration-dependent cysteine inhibition of CGA-lysine greening was attributed to redox diphenol regener

158 iptional modifications (marks) to histone H3 lysines (H3K4me3, H3K4me1, H3K27ac, H3K27me3, and H3K36m

159 Aryl-alkyl-lysines have been earlier reported to possess antimicrob

160 ice lacked epileptic seizures when fed a low lysine/high PN diet.

161 erization of Aldh7a1-KO mice consuming a low lysine/high PN diet.

162 aponica or indica germplasms identified rice Lysine-Histidine-type Transporter 1 (OsLHT1) as a candid

163 In this study, in silico analyses of the lysine histone demethylases (KDMs) involved in diverse b

164 These data suggest that the three lysines in the lyase active site destabilize pol beta wh

165 g/counterscreening strategy to generate an L-lysine insensitive LysG-based biosensor.

166 imine formed between circulating glucose and lysine is also stress labile.

167 Gain-of-function mutations in with no lysine (K) 1 (WNK1) and WNK4 genes are responsible for f

168 Emerging data have demonstrated histone lysine (K) methylation by methyltransferase SETDB1 as a

169 ons that were dependent on the presence of a lysine (K) or a glutamine (Q) at amino acid position 223

170 We identified lysine (K)270 as a target regulating RANKL signaling as

171 identifying a novel p53 acetylation site at lysine K136, we found that simultaneous mutations at all

172 f the methyltransferase SETD1B on histone H3 lysine K4 (H3K4) histone trimethylation on inflammatory

173 Additionally, the glycine (G6) and lysine (K7) residues of the Walker A motif (-GPAGTG(6)K(

174 acts as an H-bond acceptor for the catalytic lysine (K745) in the "alphaC-helix out" inactive state.

175 c the interactions of the natural acetylated lysine (KAc) histone substrate through key interactions

176 velopment and application of atypical acetyl-lysine (KAc) methyl mimetics to take advantage of the di

177 lized in a new histone modification, histone lysine lactylation, to regulate gene expression in macro

178 The mitochondrial acetyl-lysine landscape of DKO hearts was elevated well beyond

179 ine, isoleucine, histidine, but limiting for lysine, leucine, and threonine.

180 t lysine-auxotrophic mutant lys- encountered lysine limitation, an evolutionarily novel stress, cells

181 Switching mice to a high lysine/low PN diet led to vigorous seizures and a quick

182 olled seizures and improved survival of high-lysine/low PN fed KO mice.

183 ation of stereospecific bindings of l- and d-lysine (Lys) in achiral MFI zeolites.

184 ubiquitin-like modifier (SUMO) proteins to a lysine (Lys) residue on target proteins, enhances EZH2 t

185 Recently, adhesive synergy between flanking lysine (Lys, K) and 3,4-Dihydroxyphenylalanine (DOPA, Y)

186 ulfonyl fluorides that target a noncatalytic lysine (Lys162) in eIF4E.

187 active site, where it then uses an arginine/lysine-mediated hydrogen-bonding network to reposition t

188 ing an intriguing connection between biotin, lysine metabolism and systemic disease resistance signal

189 accumulated high concentrations of upstream lysine metabolites including Delta1-piperideine-6-carbox

190 Lysine, methionine, and cysteine usage also contribute t

191 th Ezh2 phosphorylation also prevented Stat3 lysine methylation and transcriptional activity.

192 Protein-lysine methylation is a common posttranslational modific

193 Lysine methylation is a key regulator of protein-protein

194 Here, we explore the role played by lysine methylation of flagellin in Salmonella, which req

195 We show that Stat3 phosphorylation, lysine methylation, and transcriptional activity increas

196 tralizing activities by interfering with its lysine methylation.

197 Reciprocal changes in histone lysine methylation/demethylation of M(LPS + IFN-gamma)/M

198 yl-l-lysine, which provides insight into the lysine methylome.

199 We found that ASH1-like histone lysine methyltransferase (ASH1L) is overexpressed in ATC

200 thyl groups by multiple complexes of histone lysine methyltransferase 2 (KMT2) family proteins.

201 by mutations in the histone-modifying enzyme lysine methyltransferase 2D (KMT2D).

202 in unique to the ASCP genomes, including the lysine methyltransferase SMYD2 and the pancreatic cancer

203 S-adenosylmethionine (SAM)-dependent histone lysine methyltransferases (KMTs), a genuinely important

204 , there are >100 known and candidate protein lysine methyltransferases (PKMTs), many of which are lin

205 SMYD lysine methyltransferases target histones and nonhistone

206 rized SET domain (SETD) proteins are protein lysine methyltransferases, but SETD3 was recently demons

207 h structural homology with two known protein lysine methyltransferases-human SETD6 and the plant LSMT

208 Plants evolved lysine motif (LysM) receptors to recognize and parse mic

209 Removal of the poly-lysine motif or disrupting the FERM-folded configuration

210 e mutations, particularly a glutamic-acid-to-lysine mutation at amino acid residue 627 (E627K) in the

211 This allows the lysine myrisotylation-demyristoylation cycle to couple t

212 a case study, we observe increased in vitro lysine N-malonylation by malonyl-CoA near nucleotide-bin

213 resence of high levels of heterochromatic H3 lysine nine trimethylation (H3K9me3).

214 de evidence that the conserved beta-3 strand lysine of protein kinases (Lys111 of PDK1) functions as

215 cogenides (COCs), are covalently attached to lysines of wild-type streptavidin.

216 ations as acetylmimetics to map the relevant lysines on actin for INF2 regulation, focusing on K50, K

217 hesis of des-bromo-des-methyl-jasplakinolide-lysine opens a way to better fluorescent probe perspecti

218 acing corresponding rTRPV1 residue E570 with lysine or glutamine retained capsaicin sensitivity.

219 as well as acetaldehyde adduct formation on lysine or histidine residues.

220 has been dominated by random modification of lysines or more site-specific labeling of cysteines, eac

221 born error of cationic amino acid (arginine, lysine, ornithine) transport caused by biallelic pathoge

222 nges in the abundance of specific acetylated lysine peptides measured in DKO versus Sirt3 KO hearts w

223 Lysine polyphosphorylation (K-PPn) is a relatively new p

224 Intracellular gating involves lysine protonation on inner helices and the formation of

225 d to proteins provides multiple times of new lysine reaction sites for the growth of subsequent EK la

226 S suggested that intrinsic cysteine, and not lysine, reactivity was important for activity against HC

227 The drug JQ1, which inhibits histone acetyl-lysine reader bromodomains, has shown promise for multip

228 ion mode distinct from the typical trimethyl-lysine reader.

229 the discovery of a peptide containing methyl lysines recognized by a mAb that binds to native HBHA ~1

230 ubsites, and mutagenesis identified a mobile lysine residue as a key determinant of positional specif

231 ate of Zta may be determined by the specific lysine residue being modified.

232 ity to modify the net charge of the modified lysine residue from + 1 to - 1 at physiological pH.

233 re frataxin (79-207) in which the N-terminal lysine residue has been lost.

234 ining receptors, and that a methionine and a lysine residue in the ligand binding pocket (GluN2D-Met7

235 ains used for modification of their acylated lysine residue in the second, more conserved acylation s

236 Acetylation or mutation of the lysine residue stabilizes FAAP20 by preventing its ubiqu

237 macroH2A1/2 at the divergent N-terminal tail lysine residue.

238 ough a mechanism dependent on its C-terminal lysine residue; its deletion led to modest reductions in

239 sult of increased acetylation of key histone lysine residues (acetylated histone 3 lysine 27 and hist

240 mediated by three conserved, surface-exposed lysine residues (triK), which were previously shown to b

241 density is surrounded by the side chains of lysine residues 290 and 294 from R2 and lysine 370 from

242 In cells expressing Msh3 in which these lysine residues are mutated to arginine, the inhibitory

243 silon-amino groups of two internal conserved lysine residues by co-expressed toxin-activating acyltra

244 and FljB, are methylated at surface-exposed lysine residues by FliB.

245 We also noted a decrease in glycated lysine residues in collagen, indicating that the imine f

246 Methylation of lysine residues in histone proteins is catalyzed by S-ad

247 by an E1 ligase inhibitor or by mutating two lysine residues in intracellular loop three causes Smo t

248 Five key lysine residues in Msh3 are direct targets of HDAC3 deac

249 direct RNF168 orientation towards the target lysine residues in proximity to the H2A alpha1-extension

250 y oxPLs, forming stable pyrrole adducts with lysine residues in the helices 3-4 of another apoA-I or

251 eraction between tau and LRP1 is mediated by lysine residues in the microtubule-binding repeat region

252 are necessary for recognition of acetylated lysine residues in the N-terminal regions of histones.

253 Mutation of four out of a total of nine lysine residues in Zta largely abrogates its ubiquitinat

254 ts whether both or only one of two conserved lysine residues of the protoxin will be posttranslationa

255 er proteins that bind to specific acetylated lysine residues on histone tails where they facilitate t

256 We show that acetylation of two key lysine residues on TULP3 by p300 increases TULP3 protein

257 The ubiquitin modification targets 4 lysine residues on Zta, leading to both mono- and polyub

258 L-lysine (EPL), a polypeptide formed by ~ 25 lysine residues with known antimicrobial activity agains

259 of the small ubiquitin-like protein NEDD8 to lysine residues, interrupts degradation of DNMT3A1.

260 SIRT6 deacetylated DDB2 at two lysine residues, K35 and K77, upon UV stress and then pr

261 S-acylate and N-acylate protein cysteine and lysine residues, respectively.

262 ranslation modification (PTM) that occurs on lysine residues.

263 nctions in the cell by deacetylating histone lysine residues.

264 and 2 can efficiently myristoylate specific lysine residues.

265 vention in ovarian cancer, we identified the lysine rich coiled-coil 1 (KRCC1), as a potential target

266 Dimerization is stimulated by the lysine-rich carboxyl-terminal extension of UBE2S that is

267 We found that a Plasmodium-specific lysine-rich insertion within the catalytic domain of PfC

268 served that truncated constructs lacking the lysine-rich insertion, or the membrane-binding domain pr

269 Using an RNA-binding lysine-rich region, DZIP3 interacted with the AU-rich re

270 We will highlight the lysine-rich regions, protein-protein interaction sites,

271 ubiquitylation of RNAPII itself, at a single lysine (RPB1 K(1268)), is the focal point for DNA-damage

272 nprecedented myristoylation of an N-terminal lysine side chain, providing evidence that NMT acts both

273 ) p300 and its paralog CBP acetylate histone lysine side chains and play critical roles in regulating

274 roducts can provide protein abundance and/or lysine site modification level information all from a si

275 ding information on solvent accessibility of lysine sites, dead end iqPIR cross-linked products can p

276 LSD1 (lysine specific demethylase; also known as KDM1A), the f

277 Lysine-specific demethylase 1 (LSD1) targets cellular pr

278 and identified sensitivity to inhibitors of lysine-specific demethylase 1 (LSD1).

279 Lysine-specific demethylase 4A (KDM4A) demethylates H3K9

280 adenocarcinoma (PDAC), while KDM6A, encoding Lysine-specific demethylase 6A, carries somatic mutation

281 Subsequently, Phf21b recruits the lysine-specific demethylase Lsd1 and histone deacetylase

282 KDM4B is a lysine-specific demethylase with a preferential activity

283 that inhibition of the epigenetic regulator lysine-specific histone demethylase 1A (LSD1) induces a

284 that deprotonate the epsilon-amino group of lysine substrate, also involving two nearby serine resid

285 We demonstrate the detection of lysine synthesized by only a few living cells in microfl

286 a general strategy for developing selective lysine-targeted covalent ligands.

287 ransglutaminase in the absence of sufficient lysine through changes to the hydrophobicity of the prot

288 However, lysine to glutamic acid substitutions at the KTKEGV repe

289 1 ubiquitination, we converted each of these lysines to arginine and found that replacing two of thes

290 Here we use lysine-to-glutamine mutations as acetylmimetics to map t

291 wly discovered oncohistone mutations include lysine-to-methionine substitutions at positions 27 and 3

292 odel proteins, including the APC-superfamily lysine transporter Lyp1.

293 t ligands (L1-L5) were synthesized using the lysine-urea-glutamate scaffold, and PSMA inhibition cons

294 epare four new agents with either one or two lysine-ureido-glutamate pharmacophores.

295 Overall, the findings suggest aryl-alkyl-lysines warrant further investigation as novel agents to

296 Des-bromo-des-methyl-jasplakinolide-lysine was coupled with red-emitting fluorescent dyes 58

297 cts and the model nucleophile N-alpha-acetyl-lysine, we identified the alpha,beta-unsaturated dialdeh

298 Controls where lysines were mutated with charged residues accessed simi

299 such as the identification of N(2)-methyl-l-lysine, which provides insight into the lysine methylome

300 zed virus strains, except for replacement of lysine with arginine at 378th position of the cryptic ep