ライフサイエンスコーパス: lysosomal

1 ich we previously showed to ameliorate other lysosomal abnormalities of cystinotic cells.

2 These results strongly suggest that lysosomal Ac in podocytes is essential for the maintenan

3 Lysosomal acid ceramidase (Ac) has been shown to be crit

4 d a novel downstream transcriptional target, lysosomal acid lipase (LAL).

5 ions in the GAA gene, resulting in deficient lysosomal acid-alpha-glucosidase activity in patients, a

6 The lysosomal acidic microenvironment can activate the assem

7 based dynamic assembly system that achieves lysosomal acidic microenvironment specifically inducing

8 As a consequence, lysosomal acidification and degradation of phagocytosed

9 of mTORC1-ATF4 hyperactivation and impaired lysosomal acidification in beta-cells lacking Furin, cau

10 rorenin receptor, respectively, and impaired lysosomal acidification.

11 tify iron homeostasis as the key function of lysosomal acidity for cell proliferation.

12 Repression of lysosomal activation in HSCs led to further enlargement

13 oded ratiometric pHlys biosensor, pHLARE (pH Lysosomal Activity REporter), which localizes predominan

14 acropinocytosis of CPPs results in increased lysosomal activity, NLRP3 inflammasome activation, and I

15 this by regulating mitochondrial fission and lysosomal activity, suppressing glucose uptake, and main

16 ons by NMT1 was largely mediated through the lysosomal adaptor LAMTOR1.

17 Here, we identified the late endosomal/lysosomal adaptor MAPK and mTOR activator (LAMTOR) compl

18 d a clear link between parkin deficiency and lysosomal alterations.

19 -EM structures of Rags in complex with their lysosomal anchor complex Ragulator and the cytoplasmic t

20 ctivates TFEB, which increases expression of lysosomal and autophagosomal genes, and that TFEB activa

21 dysregulation of genes within the endosomal-lysosomal and autophagy pathways, cytoskeletal elements,

22 The protein was degraded by both lysosomal and proteasomal pathways, and its levels were

23 Mitochondrial and lysosomal anomalies culminate in the generation of short

24 mRNA levels for lysosomal-associated membrane protein 3 (LAMP3), a gene

25 in the galactosidase beta1 (GLB1) gene cause lysosomal beta-gal deficiency, resulting in accumulation

26 n the galactosidase beta 1 (GLB1) gene cause lysosomal beta-galactosidase (beta-Gal) deficiency and c

27 es raise questions about the identity of the lysosomal binding partner of the C9orf72 complex and the

28 tion factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy(4,5), is phosphorylat

29 n factors TFEB and TFE3-master regulators of lysosomal biogenesis and autophagy-control ER-phagy by i

30 (TFEB)-a master transcriptional regulator of lysosomal biogenesis and autophagy-is activated during t

31 tion factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy.

32 tween anabolism and catabolism by regulating lysosomal biogenesis and autophagy.

33 B (TFEB) functions as a master controller of lysosomal biogenesis and function during lysosomal stres

34 Light-mediated induction of lysosomal biogenesis and function is impaired in the RPE

35 ng pathways; in turn, the nucleus fine-tunes lysosomal biogenesis and functions through transcription

36 LAMP1, LAMP2, and RAB7 proteins required for lysosomal biogenesis and fusion.

37 w that the light-responsive miR-211 controls lysosomal biogenesis at the beginning of light-dark tran

38 he autophagosomal pathway and the control of lysosomal biogenesis by TFEB, thus ensuring coordinated

39 dysfunction induced by gene inactivations of lysosomal biogenesis or acidification factors causes vit

40 ore periodic pattern by a second mutation in lysosomal biogenesis or acidification.

41 Pharmacological restoration of lysosomal biogenesis through Ezrin inhibition rescued th

42 tion factor EB (TFEB), a master regulator of lysosomal biogenesis, plays an essential role in the lys

43 a network of genes involved in autophagy and lysosomal biogenesis, were examined in the context of C.

44 turn activates TFEB, the master regulator of lysosomal biogenesis.

45 the PIKfyve lipid kinase complex, is key for lysosomal biology.

46 increased P23H rhodopsin degradation via the lysosomal but not the proteasomal pathway.

47 , phagocytosis is driven by these local endo-lysosomal Ca(2+) nanodomains rather than global cytoplas

48 imaging with genetics, we here identify the lysosomal Ca2+ channel Trpml as an essential player in t

49 omes, where lipidated LC3 interacts with the lysosomal calcium channel TRPML1, facilitating calcium e

50 ng MTBR and this process is dependent on the lysosomal calcium channel TRPML1.

51 g mitochondrial calcium dynamics through the lysosomal calcium efflux channel, transient receptor pot

52 Lysosomal calcium release by TRPML1 promotes calcium tra

53 inhibitors of parasite cathepsins L and host lysosomal cathepsin L, S and K cysteine proteases (inhib

54 now demonstrate that an interaction with the lysosomal cationic amino acid transporter PQLC2 mediates

55 creased by the availability of nutrients and lysosomal ceramide.

56 at plays a crucial role in the metabolism of lysosomal ceramides, important members of the sphingolip

57 ling functions require precise regulation of lysosomal cholesterol content.

58 Lysosomal cholesterol egress requires two proteins, NPC1

59 endosomal LDL trafficking and NPC1-dependent lysosomal cholesterol export.

60 he NPC1 cholesterol transporter and licenses lysosomal cholesterol export.

61 Niemann-Pick C1 (NPC1) is a lysosomal cholesterol storage disorder, that severely af

62 y epithelial cells, infectious diseases, and lysosomal clearance disorders.

63 ally distinct catabolic pathways that ensure lysosomal clearance of a model organelle, the endoplasmi

64 has been argued to be critical for efficient lysosomal clearance; however, its context to autophagic

65 to investigate the impact of PARK2 KO on the lysosomal compartment and found a clear link between par

66 H84T is internalized into the late endosomal/lysosomal compartment and inhibits virus-endosome fusion

67 redirects the U21/class I MHC complex to the lysosomal compartment is poorly understood.

68 show that DSTYK is located in late endosomal/lysosomal compartments and is involved in the lysosome b

69 uantitative image analysis, we show that the lysosomal content and activity are globally elevated in

70 d electron-lucent lysosomes and an increased lysosomal content, which was exacerbated by mitochondria

71 torage disorder caused by dysfunction of the lysosomal cotransporter cystinosin, leads to cystine acc

72 ephropathic cystinosis that are unrelated to lysosomal cystine accumulation.

73 Here we show how lysosomal damage activates AMPK.

74 placement, were detected in model systems of lysosomal damage inflicted by proteopathic tau and durin

75 enesis and autophagy-is activated during the lysosomal damage response, and its activation is depende

76 In addition, lysosomal damage triggers LC3 recruitment on lysosomes,

77 levels, pathogens, energy availability, and lysosomal damage, with the goal of restoring cellular ho

78 m for NLRP3 activators that function through lysosomal damage.

79 se model of oxalate nephropathy accompanying lysosomal damage.

80 l changes within the Gal9 interactome during lysosomal damage.

81 coordinates ESCRT and autophagy responses to lysosomal damage.

82 Inhibition of mTORC1 rescues the lysosomal defects and vulnerability to energetic stress

83 dition, elevating miR-195 rescues AD-related lysosomal defects in inducible pluripotent stem cells (i

84 rgeting of LAMTOR1 recapitulated most of the lysosomal defects of targeting NMT1, including defective

85 ocesses that encompasses insulin resistance, lysosomal defects, decreased survival factors, increased

86 MHC-I molecules are selectively targeted for lysosomal degradation by an autophagy-dependent mechanis

87 in lysosome deacidification, inactivation of lysosomal degradation enzymes, and disruption of antigen

88 cated in turnover of aged organelles through lysosomal degradation in the cell body.

89 Sym004 induced lysosomal degradation independently of EGFR ubiquitylati

90 pathway cannot go to completion (e.g., when lysosomal degradation is impaired) may instead exacerbat

91 Inhibition of NMT1 impaired lysosomal degradation leading to autophagy flux blockade

92 llin in cells, and strumpellin inhibited the lysosomal degradation of CAV1.

93 here that autophagy, a pathway allowing the lysosomal degradation of intracellular components, plays

94 ng it release through exosomes and promoting lysosomal degradation of misfolded prion proteins in can

95 iency of each of the enzymes involved in the lysosomal degradation of mucopolysaccharides.

96 regulator of exosome release, supporting the lysosomal degradation of SDC4 and syntenin.

97 TSPN6 with syntenin and the TSPN6-dependent lysosomal degradation of SDC4-syntenin.

98 of the perturbed AP-1 sorting, m154 promotes lysosomal degradation of several proteins involved in T

99 GSK3008348 induces rapid internalization and lysosomal degradation of the alphavbeta6 integrin.

100 cally promotes ubiquitination and subsequent lysosomal degradation of the LDLR and thus controls cell

101 This ultimately leads to lysosomal degradation of the vacuole.

102 Autophagy-a lysosomal degradation pathway that maintains cellular ho

103 As part of the lysosomal degradation pathway, the endosomal sorting com

104 misfolded proinsulin aggregate destined for lysosomal degradation via ER-phagy.

105 directing secreted and membrane proteins for lysosomal degradation, with broad implications for bioch

106 Sac1(ts) retinal cells due to impaired endo-lysosomal degradation.

107 traluminal vesicles for signal silencing and lysosomal degradation.

108 -independent manner; NS2B3 licensed Nrf2 for lysosomal degradation.

109 the modified proteins to autophagy-mediated lysosomal degradation.

110 g LGR5 receptor and DVL2 for proteasomal and lysosomal degradation.

111 fects of targeting NMT1, including defective lysosomal degradation.

112 ts their trafficking into late endosomes and lysosomal degradation.

113 tbDeltapks2 exhibited a further reduction in lysosomal delivery compared with the WT.

114 which cytoplasmic contents are targeted for lysosomal digestion, has homeostatic functions including

115 aracterized, autosomal recessively inherited lysosomal disease caused by mutations in lysosomal traff

116 BAQ13 ONNs are highly effective in inducing lysosomal disruption, lysosomal dysfunction and autophag

117 contained macrophages with hyperacetylated, lysosomal disulfide-HMGB1 that increased postreperfusion

118 stasis in NPC1-deficient cells via enhancing lysosomal dynamics and functions.

119 effective in inducing lysosomal disruption, lysosomal dysfunction and autophagy blockade and exhibit

120 te and which nutrients become limiting under lysosomal dysfunction are unclear.

121 Finally, our experiments revealed that lysosomal dysfunction dramatically alters mitochondrial

122 growing evidence indicates that the role of lysosomal dysfunction in human diseases goes beyond rare

123 We show that the lysosomal dysfunction induced by gene inactivations of l

124 Lysosomal dysfunction is considered pathogenic in Alzhei

125 Severe lysosomal dysfunction leads to microalbuminuria in some

126 is sufficient to recapitulate inflammation, lysosomal dysfunction, and hyperproliferation in a cell-

127 including the oxidative stress, DNA damage, lysosomal dysfunction, inflammatory cascade, apoptosis,

128 and sufficient for cell proliferation under lysosomal dysfunction.

129 nder both pharmacologic and genetic-mediated lysosomal dysfunction.

130 nteract retinal degeneration associated with lysosomal dysfunction.

131 ection between mitochondrial dysfunction and lysosomal dysregulation in PD pathogenesis.

132 tion of endogenous tau, which accumulates in lysosomal/endosomal compartments.

133 ar acetylome, with chloroquine, to alter the lysosomal environment to favor stability of the traffick

134 tions in the GBA gene, which encodes for the lysosomal enzyme beta-glucocerebrosidase (GCase), result

135 pression of galactocerebrosidase (GALC), the lysosomal enzyme deficient in Krabbe disease.

136 Mutations in the GBA gene, which encodes the lysosomal enzyme glucocerebrosidase (GCase), are the mos

137 in to saposin C, a critical activator of the lysosomal enzyme glucocerebrosidase (GCase).

138 age disorder caused by the deficiency of any lysosomal enzyme required for the breakdown of glycosami

139 ficiency results in inefficient ER export of lysosomal enzymes and diminished levels of the enzymes a

140 Lysosomal enzymes are synthesized in the endoplasmic ret

141 mes of the lysosomal system), which recruits lysosomal enzymes at the ER to promote their Golgi trans

142 torage disorders rely on cross-correction of lysosomal enzymes.

143 l biogenesis, plays an essential role in the lysosomal exocytosis of selected tau species.

144 nd supporting the concept that TFEB-mediated lysosomal exocytosis promotes cellular clearance, we sho

145 lymphocytes, and electron microscopy showed lysosomal (fingerprint) inclusions in all 8 patients.

146 The lysosomal folliculin (FLCN) complex (LFC) consists of th

147 ect of advanced aging, genetic disruption of lysosomal function accelerated the accumulation of stora

148 hosphate multikinase, promotes autophagy and lysosomal function and biogenesis in a TFEB-dependent ma

149 tablishes a membrane potential essential for lysosomal function and its dysregulation is associated w

150 this network and associated receptors modify lysosomal function and subsequently impact both SNCA deg

151 at common variability at genes implicated in lysosomal function exerts the largest effect on GBA asso

152 that pharmacological interventions targeting lysosomal function in general, and those particularly ca

153 wever, mechanisms linking nutrient-dependent lysosomal function to insulin secretion and more general

154 ntimate interplay of the mTORC1 pathway with lysosomal function, validating the approach.

155 ds in a manner that is dependent upon intact lysosomal function.

156 GRN has emerged as an important regulator of lysosomal function.

157 l3 and ALIX were required for restoration of lysosomal function.

158 ork for understanding the role of TMEM175 in lysosomal function.

159 acuolar abnormalities suggestive of impaired lysosomal function.

160 tion factor EB (TFEB), a master regulator of lysosomal functions and autophagy.

161 strated new analytical tools to characterize lysosomal functions and microenvironment in human neuron

162 We show that NMT1 is required for both lysosomal functions in cancer cells.

163 either originate from lysosomes or regulate lysosomal functions.

164 y, the degradation of cytoplasmic content by lysosomal fusion, is an evolutionary conserved process p

165 delimited structures (autophagosomes) before lysosomal fusion.

166 PFFs, but not monomeric alpha-syn, inhibited lysosomal GCase activity in these cells and induced the

167 tration of TFEB, preventing induction of the lysosomal genes required for lysosome function.

168 ought to better understand the regulation of lysosomal genes whose expression does not appear to be c

169 , controlling most but, importantly, not all lysosomal genes.

170 he Mediator complex and with mRNAs of target lysosomal genes.

171 A activity, and decreased phosphorylation of lysosomal GFAP, with no change in macroautophagy.

172 Galactosidase (beta-gal), one of the typical lysosomal glycosidases, is reported to be a vital biomar

173 oton exchanger CLC-7 plays critical roles in lysosomal homeostasis and bone regeneration and its muta

174 ts from the modulation of Tor signalling and lysosomal homeostasis within interstitial cells.

175 PreC layer III projection neurons contain lysosomal hydrolase cathepsin D (CatD), a marker of neur

176 Mutations in GBA1, the gene encoding the lysosomal hydrolase glucocerebrosidase (GCase), are a ri

177 ue to the secretion and subsequent uptake of lysosomal hydrolases by adjacent cells, often referred t

178 he cellular activities of autophagy and some lysosomal hydrolases.

179 al inhibitors MG132 and ALLN rather than the lysosomal inhibitors leupeptin and pepstatin A, suggesti

180 At later time points following lysosomal injury, Gal3 controlled autophagic responses.

181 of both known and new lysosomal membrane and lysosomal-interacting proteins in human iPSC-derived neu

182 Here we show that ion selectivity of the lysosomal ion channel TPC2, which is hotly debated (Calc

183 r findings uncover a broadened PSEN1 role in lysosomal ion homeostasis and novel pH modulation of lys

184 GBA1 encodes the lysosomal lipid hydrolase glucocerebrosidase (GCase), an

185 ling through the Rag GTPases promotes mTORC1 lysosomal localization and subsequent activation.

186 odeling, molecular dynamics simulations, and lysosomal localization experiments were performed on TME

187 fied ATXN3 as a Ub-Rheb deubiquitinase whose lysosomal localization is blocked by active Rag heterodi

188 to decreased Raptor acetylation and reduced lysosomal localization of mTOR, resulting in impaired ac

189 WDR41 and the DENN domain of SMCR8 drive the lysosomal localization of the complex in conditions of a

190 onductance of the transmembrane protein, and lysosomal localization was not affected by these variant

191 f the LD can be "extruded" directly into the lysosomal lumen under nutrient-limited conditions.

192 LC-7 from the degradative environment of the lysosomal lumen.

193 ol and lipids in the late endosomal (LE) and lysosomal (Ly) compartments.

194 Amino-acid-induced lysosomal mechanistic target of rapamycin complex 1 (mTO

195 hich localized to active puncta that promote lysosomal-mediated stimulator of interferon genes (STING

196 complementary coverage of both known and new lysosomal membrane and lysosomal-interacting proteins in

197 ted to also interact with the late endosomal/lysosomal membrane glycoprotein CLN3 (ceroid lipofuscino

198 caused by mutations in CLN3, which encodes a lysosomal membrane protein(1-3).

199 nase Calpha, as well as reduced abundance of lysosomal membrane proteins such as LAMP1.

200 At the lysosomal membrane, CMA is inhibited by Akt-dependent ph

201 is a K(+)-selective ion channel expressed in lysosomal membranes, where it establishes a membrane pot

202 The regulation of lysosomal metabolic functions by NMT1 was largely mediat

203 xpected essential role for NMT1 at promoting lysosomal metabolic functions.

204 PARK2 KO neurons exhibited a perturbed lysosomal morphology with enlarged electron-lucent lysos

205 lockade of its degradation instigates robust lysosomal mTORC1 localization and its activation without

206 ntry is independent of the conventional endo-lysosomal network.

207 nd exhibit dysregulation in inflammatory and lysosomal networks.

208 fy it as a dynamically regulated effector in lysosomal nutrient signaling.

209 beta-Coronavirus-induced exploitation of lysosomal organelles for egress provides insights into t

210 f several GTPases essential to the endosomal-lysosomal pathway and is implicated in protein secretion

211 Autophagy is a conserved lysosomal pathway for the degradation of cytoplasmic com

212 ys revealed that NUB1 affected the autophagy-lysosomal pathway primarily via the UBA domain.

213 Loss of GCase activity impairs the autophagy lysosomal pathway resulting in increased alpha-synuclein

214 UB1 plays a role in regulating the autophagy-lysosomal pathway when the ubiquitin proteasome system i

215 a process of degradation that occurs via the lysosomal pathway, has an essential role in multiple asp

216 member of the TRIM family is degraded by the lysosomal pathway.

217 mer) and are internalized into cells through lysosomal pathway.

218 transcriptional changes in inflammatory and lysosomal pathways.

219 ecrosis from impaired energy homeostasis and lysosomal permeabilization and inflammation through the

220 IL-1beta/TNF-induced necrosis resulted from lysosomal permeabilization and release of cathepsins B a

221 2 residue and coupled to opposing changes in lysosomal pH and exocytosis.

222 are important for autophagosome turnover and lysosomal pH regulation and are associated with the earl

223 HeLa cells localizes to lysosomes and raises lysosomal pH, suggesting that in melanocytes SLC45A2 exp

224 The PAOEs rapidly hydrolyze at lysosomal pH.

225 wn to exhibit homology to LCAT and mammalian lysosomal PLA(2) , and to contain a conserved and functi

226 cytosol, whereas ATP13A2 dysfunction causes lysosomal polyamine accumulation and rupture.

227 titer genotypes, while membrane trafficking, lysosomal processes, and mechanistic target of rapamycin

228 in is involved in endocytosis, secretion and lysosomal processes, but its functions under physiologic

229 TMEM106B physically interacts with the lysosomal protease cathepsin D and is required to mainta

230 esource, we detected aberrant trafficking of lysosomal proteases to the extracellular space and the n

231 Niemann-Pick C1 (NPC1), a lysosomal protein of 13 transmembrane helices (TMs) and

232 is lost in iPSC-derived neurons lacking the lysosomal protein progranulin.

233 insight into the relationship between these lysosomal proteins, GCase, and SNCA, and reveal novel th

234 fibroblasts revealed extensive missorting of lysosomal proteins, including sphingolipid catabolism en

235 favored the modification of smaller, soluble lysosomal proteins.

236 roteins involved in RNA translation and some lysosomal proteins.

237 and pharmacologic mTORC1 inhibition restores lysosomal proteolysis without correcting cholesterol sto

238 m PSEN1 familial AD patients, which restores lysosomal proteolysis, calcium homeostasis, and normal a

239 the bulk of cell proteins) without affecting lysosomal proteolysis.

240 Because biogenesis of lysosomal related organelle-2 (BLOC-2) functions in the

241 imity to known Parkinson's disease genes and lysosomal-related genes.

242 lacking SL-1, MtbDeltapks2, shows attenuated lysosomal rewiring compared with the WT Mtb in both in v

243 of USP10 or G3BP1 family proteins increased lysosomal ribosomal degradation and perturbed ribosomal

244 ial translation, mitochondrial dynamics, and lysosomal signaling in regulating longevity.

245 show that the cytoplasmic tail of the human lysosomal solute carrier family 38 member 9 (SLC38A9) de

246 l saposins, which are critical regulators of lysosomal sphingolipid metabolism.

247 We observed that this enhanced lysosomal state is sustained over time and defines an ad

248 ed macrophages and suggest that this altered lysosomal state protects host cell integrity and contrib

249 reas Clcn6(-/-) mice have only mild neuronal lysosomal storage abnormalities, the affected individual

250 ns of the forebrain demonstrated progressive lysosomal storage and microglial activation despite a la

251 and its mutation can lead to osteopetrosis, lysosomal storage disease and neurological disorders.

252 s an autosomal recessive, neurodegenerative, lysosomal storage disease caused by mutations in CLN3, w

253 NEU1 is deficient in the neurodegenerative lysosomal storage disease sialidosis, and its targeting

254 B (Sanfilippo syndrome B; OMIM 252920), is a lysosomal storage disease with progressive neurological

255 As a lysosomal storage disease, all 13 of NCL's causative gen

256 and clinical onset of the neurodegenerative lysosomal storage disease, GM1 gangliosidosis.

257 the progressive and fatal neurodegenerative lysosomal storage disease, GM1 gangliosidosis.

258 Lysosomal storage diseases (LSDs) are typically caused b

259 gagement in two animal models of neuropathic lysosomal storage diseases (LSDs), Gaucher's and Krabbe'

260 Sialidosis is a rare genetic lysosomal storage disorder caused by a deficit of neuram

261 Nephropathic cystinosis, a hereditary lysosomal storage disorder caused by dysfunction of the

262 Gaucher disease is a lysosomal storage disorder caused by insufficient glucoc

263 ilippo syndrome B) is an autosomal recessive lysosomal storage disorder caused by the deficiency of a

264 Niemann-Pick type C (NPC) disease is a lysosomal storage disorder characterized by cholesterol

265 Batten disease (CLN3 disease) is a pediatric lysosomal storage disorder that presents with progressiv

266 While lysosomal storage disorders have been described for many

267 This model could be extrapolated to other lysosomal storage disorders in which immune response hin

268 Many therapies for lysosomal storage disorders rely on cross-correction of

269 goes beyond rare inherited diseases, such as lysosomal storage disorders, to include common neurodege

270 a mechanistic convergence between aging and lysosomal storage disorders.

271 throughout the CNS including accumulation of lysosomal storage material and glial activation, and has

272 etected in the cerebellum, where progressive lysosomal storage, astrocytosis and microglial activatio

273 inosin-cause the rare, autosomal, recessive, lysosomal-storage disease cystinosis.

274 urthermore, we find that cholesterol-induced lysosomal stress feed-forward activates TFEB via promoti

275 of lysosomal biogenesis and function during lysosomal stress, controlling most but, importantly, not

276 own amino acid signaling factors, limits the lysosomal surface available for mTORC1 activation.

277 lular pathogens commonly manipulate the host lysosomal system for their survival.

278 ts reveal that global alteration of the host lysosomal system is a defining feature of Mtb-infected m

279 ects the organization and functioning of the lysosomal system itself is not known.

280 RESS: ER-to-Golgi relaying of enzymes of the lysosomal system), which recruits lysosomal enzymes at t

281 ) serves as a key organizer of the endosomal-lysosomal system.

282 itical roles in the control of the endosomal-lysosomal system.

283 rol TFEB, a transcriptional activator of the lysosomal system.

284 localization, and function in the endosomal-lysosomal system.

285 deficient ubiquitin-proteasome and autophagy-lysosomal systems), neuroinflammation and oxidative stre

286 e DNA repair nuclease MRE11A and inefficient lysosomal tethering of AMPK due to deficiency of N-myris

287 teractions and becomes associated with known lysosomal trafficking and proteolytic proteins like SQST

288 demonstrate that beta-coronaviruses utilize lysosomal trafficking for egress rather than the biosynt

289 endocytosis or, surprisingly, AP1-dependent lysosomal trafficking from the Golgi.

290 pe relationship was found for NC valency and lysosomal trafficking rates.

291 ted lysosomal disease caused by mutations in lysosomal trafficking regulator (LYST).

292 sm introducing a premature stop codon in the lysosomal trafficking regulator gene (LYST) that shorten

293 We recently revealed that the late endo-lysosomal transporter ATP13A2 pumps polyamines like sper

294 e responsible for translation and subject to lysosomal turnover during nutrient stress(3-5).

295 Redox-dependent regulation of lysosomal two-pore channels by PKARIalpha was sufficient

296 nase (AMPK) inhibitor dorsomorphin decreased lysosomal V-ATPase activity and also blocked any increas

297 blocks the starvation-dependent increase in lysosomal V-ATPase activity without altering basal activ

298 red for the starvation-dependent increase in lysosomal V-ATPase activity, indicating that H89 and dor

299 sponsible for the sorting of proteins to the lysosomal vacuole is Rsp5, a member of the Nedd4 family

300 The lysosomal vacuole of budding yeast (Saccharomyces cerevi