ライフサイエンスコーパス: lysosome

1 r mTORC1 translocation and activation at the lysosome.

2 accumulation of undegraded substrates in the lysosome.

3 e in response to degradative products of the lysosome.

4 of the C. burnetii-containing vacuole to the lysosome.

5 Rheb), which in turn activates mTORC1 at the lysosome.

6 ential localization of the holoenzyme to the lysosome.

7 that delivers cytoplasmic components to the lysosome.

8 e with WLS and the degradation of WLS in the lysosome.

9 and diminished levels of the enzymes at the lysosome.

10 hagosomes deliver cytoplasmic content to the lysosome.

11 ence in response to LD interactions with the lysosome.

12 agic vesicle to the recycling organelle, the lysosome.

13 back to the cell surface or degraded by the lysosome.

14 protein (LDL), which releases cholesterol in lysosomes.

15 lowered chloride (Cl(-)) content in PSEN1 KO lysosomes.

16 result in an accumulation of cholesterol in lysosomes.

17 that PQLC2 transports across the membrane of lysosomes.

18 URF2 knockdown increases receptor sorting to lysosomes.

19 of unwanted proteins and organelles through lysosomes.

20 aracterized by dysfunctional mitochondria or lysosomes.

21 ins associated with the cytosolic surface of lysosomes.

22 availability of cationic amino acids within lysosomes.

23 inant localization within autophagosomes and lysosomes.

24 y-lipoprotein (LDL)-derived cholesterol from lysosomes.

25 anced the trafficking of phagocytic cargo to lysosomes.

26 y proximal tubular cells, and transferred to lysosomes.

27 ce and subsequently degraded in the hub cell lysosomes.

28 zation of DAF-4/BMPRII to late endosomes and lysosomes.

29 of the cysteine importer for melanosomes and lysosomes.

30 QLC2 mediates C9orf72 complex recruitment to lysosomes.

31 that regulates C9orf72 complex abundance on lysosomes.

32 ar ATPase (vATPase) V0a1 subunit delivery to lysosomes.

33 tion of TAK1 thus activating AMPK on damaged lysosomes.

34 to discover that type I IFN (IFN-I) remodels lysosomes.

35 protease activity, and proteomic profile of lysosomes.

36 f surrounding autophagosomes for delivery to lysosomes.

37 ely, HS-5 cells) by trafficking the BTZ into lysosomes.

38 units and is targeted for degradation within lysosomes.

39 m from defective end-step proteolysis inside lysosomes.

40 r are expressed ubiquitously and localize to lysosomes.

41 les that are morphologically compatible with lysosomes.

42 and Tom1 to ensure their trafficking to the lysosomes.

43 oplasmic reticulum (ER) and reroutes them to lysosomes.

44 cellular accumulation of free cholesterol in lysosomes.

45 erived quality control carriers destined for lysosomes.

46 cell death due to excessive phagocytosis of lysosomes.

47 promotes LDLR degradation in late endosomes/lysosomes.

48 ed vesicles (MDVs) to facilitate delivery to lysosomes.

49 disease, whereas loss of ATP13A2 compromises lysosomes(3).

50 ls lacking functional Rag heterodimer on the lysosome accumulate Ub-Rheb, and blockade of its degrada

51 ar ATPase subunit VMA5 expression, impairing lysosome acidification and inhibiting autophagic protein

52 mutation abolished lysosome enlargement and lysosome acidification induced by wild-type TMEM106B ove

53 IFN-I-dependent lysosome acidification was associated with elevated intr

54 uding IFITM3, SLC15A3, and CNP contribute to lysosome acidification.

55 Here, we reveal that endo-lysosomes act as platforms for a new phagocytic signalli

56 n response to external and internal stimuli, lysosomes actively adjust their distribution between per

57 sphate inhibited phagosome acidification and lysosome activity in D. discoideum and macrophages and r

58 y cytoplasmic components are degraded within lysosomes, allowing cells to maintain energy homeostasis

59 Dynamic regulation of lysosomes allows them to play key roles in cell and tiss

60 It is also unknown whether lysosomes alone might be sufficient to mediate LD turnov

61 idase 1 (NEU1) form a multienzyme complex in lysosomes along with the molecular chaperone, protective

62 The lysosome also extensively communicates with other cellul

63 litates the binding of mTORC1 to Rheb on the lysosome and is another crosstalk between the amino acid

64 th-promoting and catabolic activities of the lysosome and undergo a complex interplay that enables ce

65 mal morphology with enlarged electron-lucent lysosomes and an increased lysosomal content, which was

66 with changes in the location and density of lysosomes and autophagosomes along the axon shaft.

67 At lysosomes and endosomes, the Fab1 lipid kinase complex a

68 localized to the membranes of endosomes and lysosomes and is not present or functional on the plasma

69 e role of Arl8B, an adaptor molecule between lysosomes and kinesins.

70 to monitor the dynamic interactions between lysosomes and LDs in real-time.

71 Coupling APEX2 labeling of lysosomes and metabolic labeling of protein, we identify

72 nduces an increase in the number and size of lysosomes and modifies the pH of these organelles from ~

73 positional and functional alterations in NPC lysosomes and nature of aberrant cholesterol-mTORC1 sign

74 eads to abnormalities in the distribution of lysosomes and PLP1.

75 essed ectopically in HeLa cells localizes to lysosomes and raises lysosomal pH, suggesting that in me

76 ds to the decreased sorting of hydrolases to lysosomes and reduces the autophagic degradation.

77 ulated recruitment of the C9orf72 complex to lysosomes and reveal a novel mechanism that allows cells

78 ealizes endogenous beta-gal visualization in lysosomes and shows brighter fluorescence than Hx-Gal in

79 se cathepsin A (CatA) is distributed between lysosomes and the extracellular matrix (ECM).

80 In lysosomes and the ruffled border of osteoclasts, CLC-7 r

81 ing the complement system, oxidative stress, lysosomes, and inflammation is prominent in the later ph

82 ological alterations (endoplasmic reticulum, lysosomes, and NFkB) caused by these samples.

83 ganelles such as mitochondria, chloroplasts, lysosomes, and the endoplasmic reticulum.

84 Mitochondria and lysosomes are critical for cellular homeostasis, and dys

85 Mitochondria and lysosomes are functionally linked, and their interdepend

86 Lysosomes are in the center of the cellular control of c

87 vious study, we showed that acidified amebic lysosomes are required for both amebic trogocytosis and

88 recently to integrate novel functions of the lysosome as a key signaling center, which can steer the

89 Together, these discoveries highlight the lysosome as a regulatory hub for cellular and organismal

90 y-independent processes of cargo delivery to lysosomes as well as nutrient-dependent lysosomal signal

91 Studies of lysosome associated protein transmembrane 4B (LAPTM4B) h

92 utophagy sequestration of Mtb, evolving into lysosome-associated autophagosomal Mtb degradation linke

93 propose that MDV trafficking is mediated by lysosome-associated membrane protein 1 (LAMP-1)-positive

94 lized tetherin is sequestered in a CD63- and lysosome-associated membrane protein 1 (LAMP1)-positive

95 idase (APEX) gene to the endogenous locus of lysosome-associated membrane protein 1 (LAMP1).

96 patients identified increased expression of lysosome-associated membrane protein 3 (LAMP3/CD208/DC-L

97 ding synergy is exclusively dependent on the lysosome biogenesis and autophagy transcription factor H

98 LN6 and the EGRESS complex as key players in lysosome biogenesis and shed light on the molecular etio

99 tion requires the induction of autophagy and lysosome biogenesis for the efficient recycling of macro

100 ysosomal compartments and is involved in the lysosome biogenesis in mammalian cells.

101 tyk knockdown inhibits notochord vacuole and lysosome biogenesis through mTORC1-dependent repression

102 increases association between mTORC1 and its lysosome-borne activators, leading to mTORC1 hyperactivi

103 that SKIP is not just a passive connector of lysosome-bound ARL8 to kinesin-1 but is itself subject t

104 ells where PS is low, LDL cholesterol leaves lysosomes but fails to reach the ER, instead accumulatin

105 Several nanomaterials can be entrapped in lysosomes, but the development of functional nanomateria

106 V-ATPase assembly and activity in mammalian lysosomes, but the signaling pathways controlling this e

107 , such as TPP1, which are transported to the lysosome by receptors, such as M6PR and LRP1, are critic

108 beta-Gal negatively regulates NEU1 levels in lysosomes by competitively displacing this labile sialid

109 esponse to nutrients, mTORC1 is activated on lysosomes by Rag and Rheb guanosine triphosphatases (GTP

110 hexosylganglioside (FucGM1) antibodies using lysosome-cleavable valine-citrulline dipeptide linkers v

111 we found that TMEM106B deficiency results in lysosome clustering in the perinuclear region and a decr

112 Instead, it stimulates lysosome clustering near the nucleus as seen in TMEM106B

113 hly oxidizing reactive oxygen species in the lysosome combined with a cell-protective expression of t

114 to precisely localize sites of mitochondria-lysosome contact and reveal increases in local viscosity

115 roblasts and found both altered mitochondria-lysosome contact dynamics and defective contact-dependen

116 mitochondrial calcium uptake at mitochondria-lysosome contact sites was modulated by the outer and in

117 ch was mediated by tethering of mitochondria-lysosome contact sites.

118 on mitochondria associated with mitochondria-lysosome contact.

119 Thus, our work highlights mitochondria-lysosome contacts as key contributors to interorganelle

120 scopy, we identified a role for mitochondria-lysosome contacts in regulating mitochondrial calcium dy

121 However, whether mitochondria-lysosome contacts serve additional functions by facilita

122 ced trafficking of this mutant Mtb strain to lysosomes correlated with enhanced intracellular bacteri

123 strated that the degradative activity of the lysosome created by proteases, such as TPP1, which are t

124 tic release of beta-coronaviruses results in lysosome deacidification, inactivation of lysosomal degr

125 he mTOR pathway, reduces the number of large lysosomes, decreases apoptosis, and activates autophagy,

126 ny cellular functions, from cell division to lysosome degradation and autophagy.

127 nd is subjected to cytoplasmic autophagosome-lysosome degradation, via the autophagy protein LC3.

128 nction impedes Endoplasmic Reticulum (ER)-to-lysosome delivery of ClC-7.

129 ysosomal polyamine export as a mechanism for lysosome-dependent cell death that may be implicated in

130 g high levels of autophagy, an intracellular lysosome-dependent degradative pathway that clears the c

131 ate oxidative stress and promote autophagy-a lysosome-dependent degradative pathway that disposes of

132 Autophagy is a lysosome-dependent intracellular degradation system requ

133 However, we reveal a lysosome-dependent reaction that cleaves the GLUT8 prote

134 al steroidogenesis, suggesting conversion of lysosome-derived cholesterol to pregnenolone.

135 acterial pathogen that replicates inside the lysosome-derived Coxiella-containing vacuole (CCV).

136 lysosomes is instrumental for characterizing lysosome-driven pathways at the molecular level and moni

137 , and occupancy, which report on activity of lysosome-driven pathways.

138 tosis, reflecting its failure to localize to lysosomes due to CDK1-dependent RAPTOR phosphorylation.

139 n of ponatinib uptake and sequestration into lysosomes during the development of acquired drug resist

140 measure pHlys for improved understanding of lysosome dynamics, which is increasingly considered a th

141 endomembrane components including endosomes, lysosomes, endoplasmic reticulum and Golgi.

142 omains 2 (ADAP2), gamma-interferon-inducible lysosome/endosome-localized thiolreductase (GILT), and l

143 , we found that the D252N mutation abolished lysosome enlargement and lysosome acidification induced

144 We show that HPgammaCD treatment increases lysosome-ER association and enhances autophagic activity

145 ling of protein, we identify that individual lysosomes exhibit substantial heterogeneity in protein a

146 in the perinuclear region and a decrease in lysosome exocytosis and cell surface PLP levels.

147 luding direct plasma membrane translocation, lysosome exocytosis, exosome formation, membrane vesicul

148 that modulates secretion routes, increasing lysosome exocytosis.

149 utophagy) targets cytoplasmic cargoes to the lysosome for degradation.

150 s the targeting of cytosolic material to the lysosome for degradation.

151 proteins and organelles are delivered to the lysosome for degradation.

152 gos, which are subsequently delivered to the lysosome for degradation.

153 Tf-independent pathway and trafficked to the lysosome for degradation.

154 h cytoplasmic contents are trafficked to the lysosome for degradation.

155 or surplus mitochondria via targeting to the lysosome for destruction.

156 ntracellular components and delivers them to lysosomes for degradation and recycling.

157 mes transfer cytosolic material to acidified lysosomes for degradation following soluble N-ethylmalei

158 ed signaling receptors and other proteins to lysosomes for degradation, but they also modulate interc

159 which cells deliver cytoplasmic contents to lysosomes for degradation.

160 les and aggregated proteins are delivered to lysosomes for degradation.

161 rting of nephrin from recycling endosomes to lysosomes for degradation.

162 discoveries have transformed the view of the lysosome from a static organelle dedicated to the dispos

163 Isolated liver lysosomes from mice treated with either of two orally bi

164 NCs also trafficked to lysosomes from the apical side and, additionally, from t

165 al for ceramide hydrolysis and regulation of lysosome function and cellular homeostasis.

166 We demonstrated that PKR contributes to the lysosome function and regulates misfolded prion protein

167 We propose that IFN-I control of lysosome function broadly impacts host defense against d

168 demonstrate a role for enhanced autophagy or lysosome function in immune evasion by selective targeti

169 We hypothesized that PKR-associated lysosome function is critical for cancer but not normal

170 Lysosome function is essential for cellular homeostasis,

171 nduction of the lysosomal genes required for lysosome function.

172 Many lysosome functions are determined by a lumenal pH of ~5.

173 (2020) show that lysosomes fuse with phagosomes to maintain phagosomal me

174 rnover after treatment with an autophagosome-lysosome fusion inhibitor, chloroquine, indicating that

175 omycin-A, an inhibitor of auto-phagosome and lysosome fusion, inhibited poly I:C-induced IDO and HLA-

176 f nanopore-mediated local calcium influx for lysosome fusion, represents a biophysical mechanism for

177 cells because of inhibition of autophagosome-lysosome fusion.

178 xidation, allowing calcium entry to initiate lysosome fusion.

179 Endosomes and lysosomes harbor Rab5 and Rab7 on their surface as key p

180 For many decades the lysosome has been recognized as the terminal center of c

181 REporter), which localizes predominantly in lysosomes, has a dynamic range of pH 4.0 to 6.5, and can

182 osomes to promote phagocytosis, whereas endo-lysosome immobilization prevents it.

183 ipid droplets or organelles) to the vacuole (lysosome in mammals) for degradation and recycling.

184 y supplied PA vesicles deliver mTORC1 to the lysosome in the absence of amino acids, Rag GTPases, gro

185 and thereby sustain mTORC1 activation at the lysosome in the absence of amino acids.

186 substrates remains robustly targeted to the lysosome in the absence of several core ATGs, including

187 triggered by loss of cell adhesion activates lysosomes in C. elegans epidermis during developmental r

188 basal mTORC1 activity that drives defective lysosomes in cells and mice, leading to accumulation of

189 ng studies, we found that most endosomes and lysosomes in freshly isolated SMCs from cerebral arterie

190 itochondria, endoplasmic reticulum (ER), and lysosomes in HSC metabolism.

191 monitor the interaction of mitochondria and lysosomes in living cells.

192 in is localized in the ER, Golgi, and in the lysosomes in LMH cells.

193 of the morphology, content, and function of lysosomes in PARK2 KO neurons and reveal an important ne

194 d autophagosome formation and trafficking to lysosomes in primary human monocyte-derived macrophages

195 related beta2-adrenergic agonists reacidify lysosomes in PSEN1 Knock out (KO) cells and fibroblasts

196 e been localized to the mitochondria and the lysosome; including instability of mitochondrial DNA due

197 ated with changes in the complement cascade, lysosomes, innate immune response, and glycosaminoglycan

198 Mitochondria-lysosome interactions are essential for maintaining intr

199 dynamic tracking of functional mitochondria-lysosome interactions in living cells.

200 nsity indicates the progress of mitochondria-lysosome interplay during mitophagy.

201 Transport of LDL-derived cholesterol from lysosomes into the cytoplasm requires NPC1 protein; NPC1

202 The lysosome is an acidic multi-functional organelle with ro

203 The lysosome is an essential catabolic organelle that consum

204 While mTORC1 activation at the lysosome is well characterized, it is not clear how this

205 resolved issue is how ASMase residing within lysosomes is released extracellularly within seconds to

206 sicles can tether with endocytic organelles (lysosomes/late endosomes) by forming membrane contact si

207 the dissociation of mTOR from the surface of lysosomes leading to decreased mTORC1 activation.

208 membrane contacts between the late endosomes/lysosomes (LEL) and the endoplasmic reticulum (ER).

209 lized to the membranes of late endosomes and lysosomes (LELs).

210 phila tissues demonstrate an accumulation of lysosome-like organelles that precedes neurodegeneration

211 r bacterium that replicates within an acidic lysosome-like parasitophorous vacuole (PV) in human macr

212 localization from 6 to 12 months of age with lysosome-like structures observed in the photoreceptors.

213 Here, working in yeast, we show that the lysosome-like vacuole maintains mitochondrial respiratio

214 intracellular pathogen that replicates in a lysosome-like vacuole through activation of a Dot/Icm-ty

215 robial peptides linked to cathepsin B in the lysosomes (MACs) can be applied for the treatment of mul

216 C1) occur on the lysosome surface, increased lysosome mass with aging leads to higher mTORC1 activity

217 Lysosomes mediate enzymatic degradation of vesicle cargo

218 ta indicate that one such potential pathway, lysosome-mediated degradation of autophagy cargoes, is c

219 eplete RAS proteins through an autophagosome-lysosome-mediated degradation pathway.

220 estrogen-induced mammary cell death was via lysosome-mediated programmed cell death through upregula

221 Lysosome-mediated signalling pathways and transcription

222 llular components through autophagosomes and lysosomes, mediates the downregulation of mammalian SIRT

223 e findings identify a selective mechanism of lysosome membrane turnover that is induced by stress and

224 Here, we describe a peroxisome-lysosome metabolic link that restricts autophagic degrad

225 everal cellular compartments (i.e., nucleus, lysosomes, mitochondria, and cytoplasm) is extremely adv

226 of lysosomes to kinesin-1 and, consequently, lysosome movement toward the cell periphery.

227 WT CASMCs, which was associated with reduced lysosome-multivesicular body (MVB) interaction.

228 ipheral and perinuclear regions and modulate lysosome-nucleus signaling pathways; in turn, the nucleu

229 nal heavy and light chains accumulate in the lysosome of macrophages, leading to histiocytic reaction

230 c material and its subsequent degradation in lysosomes of eukaryotic cells, thereby providing cell-au

231 h partial colocalization in mitochondria and lysosomes of water-soluble thioglycosylated zinc(II) por

232 bacteria did not return to vacuoles such as lysosomes or autophagosomes and macrophages did not die.

233 stress responses that either originate from lysosomes or regulate lysosomal functions.

234 ansported to intra-endothelial compartments (lysosomes) or transcellularly released at the tissue sid

235 imarily accumulate within late endosomes and lysosomes, organelles that participate in the degradatio

236 liposomes also participated in the endosome/lysosome pathway (with high-efficiency BBB crossing obse

237 Importantly, the autophagy-lysosome pathway contributes to the loss of SIRT1 during

238 dge of how the disease affects the autophagy-lysosome pathway, as activating autophagy when the pathw

239 tatic tumor cells through a macropinocytosis-lysosome pathway, endowing tumor cells with augmented su

240 d mitochondria through the autophagosome and lysosome pathways.

241 Lysosome pH (pHlys) is often increased in neurodegenerat

242 (0 < 5.0), allowed us to specifically stain lysosomes (pH ~ 4.5-5.0) in live cells.

243 pathways included the complement system and lysosome/phagosome pathways.

244 d innate immunity, the complement system and lysosome/phagosome pathways.

245 Conversely, Rap1 depletion expands the lysosome population, which markedly increases associatio

246 Lysosomes promote cellular homeostasis through macromole

247 The levels of many lysosome proteins are significantly decreased in the TME

248 and specifically causes EZH2 degradation via lysosomes, reducing the cellular H3K27me3 level.

249 mammals and birds, has been documented as a lysosome-related organelle, the maturation paths of xant

250 a pathway mediating formation of intestinal lysosome-related organelles (LROs) is required for biosy

251 on of SGs might occur in a manner similar to lysosome-related organelles (LROs).

252 ranules and melanosomes, which like WPBs are lysosome-related organelles, we hypothesized that BLOC-2

253 ially entered macrophages and accumulated in lysosomes releasing Isoniazid.

254 ity-control mechanisms that maintain healthy lysosomes remain poorly characterized.

255 r, how the mTORC1 interacts with Rheb on the lysosome remains elusive.

256 owever, the transport function of ATP13A2 in lysosomes remains unclear.

257 between these organelles, the function(s) of lysosomes required to sustain mitochondrial health remai

258 Adequate function of endosomes and lysosomes requires finely tuned luminal ion homeostasis

259 s driven by active AMPK enriched on adjacent lysosomes, revealing previously uncharacterized signalin

260 ing conjugates that bind both a cell-surface lysosome-shuttling receptor and the extracellular domain

261 they remain unable to label mitochondria and lysosomes simultaneously and dynamically track their int

262 a function for LC3 lipidation in regulating lysosome size and activity through microautophagy.

263 machinery, show reduced ability to regulate lysosome size and degradative capacity in response to ac

264 f cystinosis-including cystine accumulation, lysosome size, the autophagy pathway, and apoptosis-and

265 dosis, and its targeting to and stability in lysosomes strictly depend on PPCA.

266 of rapamycin complex 1 (mTORC1) occur on the lysosome surface, increased lysosome mass with aging lea

267 The autophagy-lysosome system has been identified as a main intersecti

268 and degrees of involvement of the autophagy-lysosome system that have been discovered in ALS/FTD.

269 ear-infrared fluorescent probe Lyso-Gal with lysosome-targeting ability was developed for lysosomal b

270 a similar hemicyanine probe, Hx-Gal, without lysosome-targeting ability, Lyso-Gal realizes endogenous

271 'TLR adaptor interacting with SLC15A4 on the lysosome' (TASL), abrogated responses to endolysosomal T

272 by an intracellular route independent of the lysosome-terminal endocytic pathway.IMPORTANCE Herpes si

273 try of HSV-1 is independent of the canonical lysosome-terminal pathway.

274 is a cysteine protease of late endosomes and lysosomes that can be secreted; it exhibits maximal acti

275 rophages clear pathogens by phagocytosis and lysosomes that fuse with phagosomes are traditionally re

276 the melanosome-the organelle, related to the lysosome, that synthesizes pigment-but have unclear func

277 s that subsequently fuse with the vacuole or lysosome, thereby delivering cargo for degradation.

278 sequestration of unesterified cholesterol in lysosomes, thereby activating the sterol response elemen

279 Finally, HO2 is degraded by the lysosome through chaperone-mediated autophagy, distinct

280 l ion homeostasis and novel pH modulation of lysosomes through beta2-adrenergic regulation of ClC-7,

281 wever, the emerging evidence has brought the lysosome to the center of nutrient sensing as the organe

282 reased autophagosomes and the recruitment of lysosomes to aggresomes following proteasome inhibition.

283 d autophagosomes, which ultimately fuse with lysosomes to enable degradation of their substrates.

284 This interaction inhibits coupling of lysosomes to kinesin-1 and, consequently, lysosome movem

285 However, why cells require acidic lysosomes to proliferate and which nutrients become limi

286 se) ARL8 on the lysosomal membrane to couple lysosomes to the anterograde microtubule motor kinesin-1

287 ude that LDL cholesterol normally moves from lysosomes to the PM.

288 elective autophagy instead reroutes MHC-I to lysosomes, using the ubiquitin-binding receptor NBR1, pr

289 Lysosome (vacuole) and mitochondria decline interdepende

290 As such the lysosome was attributed a rather passive role in cellula

291 Through proteomic profiling of NPC lysosomes, we find pronounced proteolytic impairment com

292 rorganelle contacts between mitochondria and lysosomes were identified and found to regulate mitochon

293 tarvation, a fraction of p27 is recruited to lysosomes, where it interacts with LAMTOR1, a component

294 lysosomal damage triggers LC3 recruitment on lysosomes, where lipidated LC3 interacts with the lysoso

295 ant phosphoinositide lipids at endosomes and lysosomes, whereas PI 4-phosphates, such as phosphatidyl

296 on of chloride channel-7 (ClC-7) delivery to lysosomes which reverses markedly lowered chloride (Cl(-

297 cific accumulation of AMP-CatB in macrophage lysosomes, which is the key location for bactericidal ac

298 vation in HSCs led to further enlargement of lysosomes while suppressing glucose uptake.

299 ced levels of lysosomal enzymes and enlarged lysosomes with abnormal storage material.

300 abel mitochondria with blue fluorescence and lysosomes with red fluorescence, and the correlation bet