ライフサイエンスコーパス: lysyl

1 subunit (U2AF65) undergoes posttranslational lysyl-5-hydroxylation catalyzed by the Fe(II) and 2-oxog

2 We report here that Gcn5, a paradigm lysyl-acetyl transferase (KAT) modifying both histone an

3 ytic reversal involving a transient C6orf130 lysyl-(ADP-ribose) intermediate.

4 nization into plywood-like stacks depends on lysyl aldehyde-derived cross-links introduced by lysyl o

5 DNA phosphate negative charge is balanced by lysyl amines (3.2%), polyamines (5.8%), and monovalent c

6 d monovalent cations (40%); and (iii) 11% of lysyl amines, 40% of -NH(2) groups of polyamines, and 80

7 e ubiquitin carboxy terminus and a substrate lysyl amino group.

8 the C-terminal deletion mutants to hydrolyze lysyl-AMP generated by LysU was greatly impaired.

9 all classic ligases, NgrRnl forms a covalent lysyl-AMP intermediate.

10 Lysyl and prolyl hydroxylations are well-known post-tran

11 Bronchial challenge with lysyl-aspirin can be used as a confirmatory diagnostic t

12 efore and following bronchial challenge with lysyl-aspirin.

13 tor XIIIa-catalyzed epsilon-(gamma-glutamyl)-lysyl bonds between glutamine and lysine residues on fib

14 c 110kDa polypeptide (Co-hArgI x3) and (iii) lysyl conjugation of 5kDa PEG-N-hydroxysuccinimide (NHS)

15 portantly, 2-HOBA reduces the MDA- and IsoLG-lysyl content in atherosclerotic aortas versus 4-HOBA.

16 yzes the formation of gamma-glutamyl-epsilon-lysyl cross-links within the fibrin blood clot network.

17 ) introduces covalent gamma-glutamyl-epsilon-lysyl crosslinks into the blood clot network.

18 that LOXL2 readily promoted the formation of lysyl-derived cross-links in the 7S dodecamer but not in

19 ontrast, inclusion of the positively charged lysyl-dioleoyl-phosphatidylglycerol exclusively on the c

20 Investigation of hydroxyl-(beta)-lysyl-EF-P showed 30% increased puromycin reactivity but

21 recombinant EF-P preparation containing beta-lysyl-EF-P stimulated N-formyl-methionyl-puromycin synth

22 ions containing unmodified EF-P and/or alpha-lysyl-EF-P.

23 se, whereas Lc-Lys-2 is a gamma-D-glutamyl-L-lysyl endopeptidase.

24 ion and a predicted MprF protein, which adds lysyl groups to phosphatidylglycerol to neutralize membr

25 sults from mutations in the genes coding for lysyl hydroxylase (LH) 2 or peptidyl-prolyl cis-trans is

26 ate 5-dioxygenase 2 (PLOD2) encodes the only lysyl hydroxylase (LH) isoform that specifically hydroxy

27 oband bone tissue, consistent with decreased lysyl hydroxylase 1 in proband osteoblasts.

28 in B with the P-domain of calreticulin, with lysyl hydroxylase 1, and probably other proteins, such a

29 Lysyl hydroxylase 2 (LH2) catalyzes the hydroxylation of

30 Specifically, the enzymes lysyl hydroxylase 2 (LH2) or lysyl oxidase (LOX) and LOX

31 on of the alternatively spliced long form of lysyl hydroxylase 2 (LH2), a collagen telopeptide LH.

32 signaling in macrophages to the induction of lysyl hydroxylase 2 (LH2), an enzyme that directs persis

33 Lysyl hydroxylase 2 (LH2), an important alternatively sp

34 -function studies in tumor cells showed that lysyl hydroxylase 2 (LH2), which hydroxylates telopeptid

35 se associated with inactivating mutations in lysyl hydroxylase 2 (LH2/PLOD2) or FK506 binding protein

36 T3-E1 (MC)-derived clones stably suppressing lysyl hydroxylase 3 (LH3) (short hairpin (Sh) clones) an

37 Lysyl hydroxylase 3 (LH3), encoded by Plod3, is the mult

38 molecule responsible for the recruitment is lysyl hydroxylase 3 (LH3).

39 th its partner proteins, regulate sorting of lysyl hydroxylase 3 (LH3, also known as PLOD3) into newl

40 ing hypoxia-inducible factor 1 [HIF-1]), the lysyl hydroxylase JMJD6, and the RNA hydroxylase TYW5 bu

41 iron and 2OG, supported its assignment as a lysyl hydroxylase rather than an N-methyl arginyl-demeth

42 R may also act as an arginine demethylase, a lysyl hydroxylase, or an RNA-binding protein through its

43 upport the assignment of purified JMJD6 as a lysyl hydroxylase.

44 m of clinical phenotypes than the absence of lysyl-hydroxylase 1 and additionally includes myopathy,

45 which can also be caused by a deficiency in lysyl-hydroxylase 1.

46 We also found that the lysyl-hydroxylase activity of Jumonji Domain Containing

47 acting as both an arginine demethylase and a lysyl-hydroxylase.

48 he alpha-subunit of prolyl 4-hydroxylase and lysyl hydroxylases.

49 post-translationally modified by prolyl and lysyl hydroxylation and subsequently by glycosylation of

50 dependent oxygenase, catalyzes carbon 4 (C4) lysyl hydroxylation of eRF1.

51 6-[(2E)-1- oxo-3-(3-pyridinyl-2-propenyl)]-l-lysyl-l-2-aminohexanedioyl-(1-amino-1-cyclohexa ne)carbo

52 r HIS(6x)-HA(3x)-IAA1, suggesting additional lysyl-linked ubiquitin on this protein.

53 The beta-lysyl-lysine isopeptide was identified in the exhaustive

54 ere we present biochemical evidence for beta-lysyl-lysine modification in Escherichia coli EF-P and f

55 peptides" like alpha-alanyl-lysine and alpha-lysyl-lysine.

56 ert a specific lysine to a hypothetical beta-lysyl-lysine.

57 as follows: S-hydroxylysyl-methionine and S-lysyl-methionine cross-links, which stabilize the alpha3

58 Deuteration of the lysyl methyls results in identical kinetic isotope effec

59 Mass spectrometric analyses confirmed the lysyl modification at lysine 34 in native and recombinan

60 on between Phe-19 of the pore module and the lysyl moiety anchored to the phosphatidylglycerol headgr

61 of LigA with NAD(+) to form a covalent LigA-(lysyl-Nzeta)-AMP intermediate (step 1); transfer of AMP

62 ith ATP or NAD(+) to form a covalent ligase-(lysyl-Nzeta)-AMP intermediate and release pyrophosphate

63 along the reaction pathway-covalent ligase-(lysyl-Nzeta)-AMP*Mn(2+) intermediate; ligase*ATP*(Mn(2+)

64 long the reaction pathway: the covalent LIG-(lysyl-Nzeta)-AMP*Mn2+ intermediate and a LIG*ATP*(Mn2+)2

65 cted an interaction between fibromodulin and lysyl oxidase (a major collagen cross-linking enzyme) an

66 Lysyl oxidase (LOX) and LOX-like (LOXL) proteins are cop

67 ly, the enzymes lysyl hydroxylase 2 (LH2) or lysyl oxidase (LOX) and LOX-like 2 (LOXL2) were signific

68 In addition, lysyl oxidase (LOX) and LOX-like proteins, which are sec

69 In addition, lysyl oxidase (LOX) and LOX-like proteins, which are sec

70 l oxidase family is made up of five members: lysyl oxidase (LOX) and lysyl oxidase-like 1-4 (LOXL1-LO

71 we identify hypoxia-induced ECM re-modeler, lysyl oxidase (LOX) as a key inducer of chemoresistance

72 analysis of the hypoxic secretome identified lysyl oxidase (LOX) as significantly associated with bon

73 domains and the highly conserved C-terminal lysyl oxidase (LOX) catalytic domain.

74 pression of the collagen crosslinking enzyme lysyl oxidase (LOX) compared with PyMT(fl/fl) mammary ca

75 of the extracellular matrix modifying enzyme lysyl oxidase (LOX) correlates with metastatic dissemina

76 Lysyl oxidase (LOX) enzyme activity was evaluated by WB

77 helial-mesenchymal transition marker levels, lysyl oxidase (LOX) expression, and metastatic capacity.

78 y activates YAP1, which directly upregulates lysyl oxidase (LOX) expression.

79 pled with deacetylimination as a function of lysyl oxidase (LOX) family members.

80 as a result of collagen crosslinking by the lysyl oxidase (LOX) family of enzymes.

81 The lysyl oxidase (LOX) family of extracellular proteins pla

82 through induction of multiple members of the lysyl oxidase (LOX) family, including LOX, LOX-like 2, a

83 ed by the enzymatic action of members of the lysyl oxidase (LOX) family.

84 ved human MSCs promote de novo production of lysyl oxidase (LOX) from human breast carcinoma cells, w

85 AD, we identified a missense mutation in the lysyl oxidase (LOX) gene (c.893T > G encoding p.Met298Ar

86 The lysyl oxidase (LOX) gene encodes an enzyme (LOX) critica

87 The lysyl oxidase (LOX) gene reverted Ras transformation of

88 such pathologies, and recently, the protein lysyl oxidase (LOX) has been implicated in proliferation

89 The extracellular, matrix-modifying enzyme lysyl oxidase (LOX) has recently been linked to colorect

90 Here, we show a critical role for lysyl oxidase (LOX) in establishing a milieu within fibr

91 We find that reduction of lysyl oxidase (Lox) in Lkb1-deficient lung ADC decreases

92 y, hypoxic signaling increased expression of lysyl oxidase (LOX) in mesothelial and ovarian cancer ce

93 d mast cell protease expression, and induced lysyl oxidase (LOX) in the aortic wall, improved systemi

94 ession and localization of LOXL1, LOXL2, and lysyl oxidase (LOX) in tissues of PEX syndrome/glaucoma

95 Expression of lysyl oxidase (LOX) inhibits RAS transforming activity.

96 Lysyl oxidase (LOX) is a multifunctional protein require

97 Lysyl oxidase (LOX) is a potent chemokine inducing the m

98 Lysyl oxidase (LOX) is a secreted copper-dependent amine

99 Lysyl oxidase (LOX) is a secreted copper-dependent amine

100 Lysyl oxidase (LOX) is a transcriptional target of HIF1a

101 of the extracellular matrix-modifying enzyme lysyl oxidase (LOX) is essential for stimulating endothe

102 Lysyl oxidase (LOX) is overexpressed in various patholog

103 ast cancer cells increased the expression of lysyl oxidase (LOX) mRNA.

104 BMP1 also cleaves and activates the lysyl oxidase (LOX) precursor, the enzyme catalyzing the

105 Lysyl oxidase (LOX) remodels the tumour microenvironment

106 We studied the functional contribution of lysyl oxidase (LOX) to collagen stabilization and hepati

107 d is then cleaved to a 30-kDa mature enzyme (lysyl oxidase (LOX)) and an 18-kDa propeptide (lysyl oxi

108 Lysyl oxidase (LOX), a collagen cross-linking enzyme, ha

109 ypothesized that HG-induced up-regulation of lysyl oxidase (LOX), a collagen-cross-linking enzyme, in

110 d whether altered expression and activity of lysyl oxidase (LOX), a cross-linking enzyme, may comprom

111 Lysyl oxidase (LOX), a matrix cross-linking protein, is

112 the dramatic reduction in the expression of lysyl oxidase (LOX), a metastasis-promoting, matrix-remo

113 Previously, fibulin-4 was shown to bind lysyl oxidase (LOX), an elastin/collagen cross-linking e

114 A key regulator of collagen homeostasis is lysyl oxidase (LOX), an enzyme responsible for cross-lin

115 ng inhibited by a known suicide inhibitor of lysyl oxidase (LOX), beta-aminopropionitrile, which we f

116 0b; miR-200b directly inhibits expression of lysyl oxidase (LOX), leading to decreased invasion.

117 A series of studies examined the effects of lysyl oxidase (LOX), the enzyme responsible for the form

118 GFbeta1 stimulation increased collagen I and lysyl oxidase (LOX), the enzyme that cross-links soluble

119 cognized targets of the extracellular enzyme lysyl oxidase (LOX), the level of which is increased in

120 supplies Cu to the secretory enzymes such as lysyl oxidase (LOX), while Atox1 in the nucleus function

121 5q23.2, overlapping the gene coding for the lysyl oxidase (LOX).

122 ated that Atox1, ATP7A, and the proenzyme of lysyl oxidase (LOX; copper-loaded via ATP7A) are all in

123 propeptide region (LOX-PP) derived from pro-lysyl oxidase (Pro-LOX) and not on lysyl oxidase enzyme

124 x proteins such as MMP2, vimentin, uPAR, and lysyl oxidase 2.

125 Lysyl oxidase activity contributes to collagen stabiliza

126 e extracellular matrix enzymes revealed that lysyl oxidase activity is required for cross-linking of

127 ibrillin-1 microfibril assembly and secreted lysyl oxidase activity were normal in ARCL2 cells.

128 p.Ser348Arg resulted in significantly lower lysyl oxidase activity when compared with the wild-type

129 creases in extracellular matrix rigidity and lysyl oxidase activity, which can be prevented by inhibi

130 l aldehyde-derived cross-links introduced by lysyl oxidase activity, which, in turn, only weakly infl

131 tivity, which can be prevented by inhibiting lysyl oxidase activity.

132 protein (MMP-2) and unchanged expression of lysyl oxidase and a second metalloproteinase, MMP-9, in

133 The identification of lysyl oxidase and the extracellular matrix as critical r

134 and VI and the collagen crosslinking enzyme lysyl oxidase and up-regulates in vitro expression of th

135 in-4), collagens (types I, III, and IV), and lysyl oxidase crosslinking enzymes (LOX, LOXL1, LOXL2) w

136 Similarly, d-penicillamine, which inhibits lysyl oxidase enzymatic activity by depleting intracereb

137 Lysyl oxidase enzyme activity is critical for the biosyn

138 The importance of lysyl oxidase enzyme activity to normal bone development

139 from pro-lysyl oxidase (Pro-LOX) and not on lysyl oxidase enzyme activity.

140 hydroxylysine would enhance the activity of lysyl oxidase enzyme to form collagen cross-links, incre

141 a significant upregulation in both SMAD2 and Lysyl oxidase expression, compared to HCFs.

142 ition, correlating with a marked increase in lysyl oxidase expression.

143 The lysyl oxidase family is made up of five members: lysyl o

144 We also established that LOXL2 is the main lysyl oxidase family member present in the glomerular ex

145 Among all lysyl oxidase family members, lysyl oxidase-like-2 (LOXL

146 d more recently periostin and members of the lysyl oxidase family of enzymes have been documented in

147 ysyl oxidase-like 2 (LOXL2), a member of the lysyl oxidase family, as a Snail1 regulator and EMT indu

148 The lysyl oxidase gene (LOX) inhibits Ras signaling in trans

149 In addition, lysyl oxidase has tumor suppressor activity that has bee

150 lt of decreased expression and activation of lysyl oxidase in the infarcts of MMP-28(-/-) mice.

151 Inhibition of collagen crosslinking by lysyl oxidase inhibitor alleviated unilateral ureteral o

152 The lysyl oxidase inhibitor beta-aminopropionitrile disrupts

153 AB0023 outperformed the small-molecule lysyl oxidase inhibitor beta-aminoproprionitrile.

154 administration of beta-aminopropionitrile, a lysyl oxidase inhibitor.

155 found that the collagen cross-linking enzyme lysyl oxidase is expressed in all vascular cells and tha

156 viously shown that proteolytic activation of lysyl oxidase is much reduced in cultures of FN-null mou

157 Pro-lysyl oxidase is secreted as a 50-kDa proenzyme and is t

158 Lysyl oxidase-like 1 proved to be the major lysyl oxidase isoform in the normal lamina cribrosa in a

159 st, expression levels of collagens and other lysyl oxidase isoforms were not affected.

160 s correlating with a 10-fold upregulation of lysyl oxidase like-1 gene expression (P < 0.001).

161 mbly components, including fibulins 4 and 5, lysyl oxidase like-1, and fibrillin-1.

162 lly manipulating stromal matrix with an anti-lysyl oxidase like-2 (anti-LOXL2) antibody in syngeneic

163 Lysyl oxidase like-2 (LOXL2) plays a central role in fib

164 ntermolecular cross-links formed through the lysyl oxidase mechanism.

165 -terminal catalytic domains that provide for lysyl oxidase or lysyl oxidase-like enzyme activity; and

166 amino-acid propeptide domain (LOX-PP) of the lysyl oxidase precursor protein.

167 The propeptide region of the lysyl oxidase proenzyme (LOX-PP) has been shown to inhib

168 The secreted lysyl oxidase proenzyme is processed to a propeptide (LO

169 LOX has complex roles in cancer in which the lysyl oxidase propeptide (LOX-PP) domain of secreted pro

170 syl oxidase (LOX)) and an 18-kDa propeptide (lysyl oxidase propeptide (LOX-PP)).

171 Lysyl oxidase propeptide (LOX-PP), released during LOX p

172 cally increases intranuclear localization of lysyl oxidase propeptide, which interferes with NF-kappa

173 n mineralization, and Loxl4, which encodes a lysyl oxidase that catalyzes collagen crosslinking.

174 lloproteinases, IL-8, PDGFs, caveolin 1, and lysyl oxidase), several of which were associated with po

175 or 4), Yes1 (YES proto-oncogene 1), and Lox (lysyl oxidase).

176 Aldosterone and CTGF increased lysyl oxidase, and aldosterone enhanced miR-21 expressio

177 creases in the pro-synthetic elastin enzyme, lysyl oxidase, and increases in the elastin-degrading en

178 alpha-amylase, concanavalin, Pichia pastoris lysyl oxidase, and Klebsiella pneumoniae acetolactate sy

179 specifically RhoA activity as well as CTGF, lysyl oxidase, and microRNA-21 expression.

180 as those encoding hypoxia-inducible gene-2, lysyl oxidase, and vascular endothelial growth factor, a

181 ch in cysteine), crosslinking genes/enzymes (lysyl oxidase, lysyl oxidase-like 2-4, tissue transgluta

182 ltures with inhibitors of TGFbeta signaling, lysyl oxidase, or integrin beta1-mediated mechanosignali

183 s of transforming growth factor (TGF)-beta1, lysyl oxidase, periostin, and osteopontin are elevated.

184 relationship exists between fibromodulin and lysyl oxidase, potentially imparting a specific collagen

185 ollagen domain and also forms a complex with lysyl oxidase, targeting the enzyme toward specific cros

186 er280Arg), was identified in LOX, encoding a lysyl oxidase, that segregated with disease in the famil

187 growth factor (PDGF)-BB, angiopoietin-1, and lysyl oxidase-2 and the cerebrovascular-selective protei

188 Lysyl oxidase-dependent elastin fiber assembly was asses

189 Lysyl oxidase-generated intermolecular cross-links are e

190 genetic predisposition due to variations in lysyl oxidase-like 1 (LOXL1) function, leading to altere

191 Two single nucleotide polymorphisms in the lysyl oxidase-like 1 (LOXL1) gene (rs1048661 and rs38259

192 Coding variants in the lysyl oxidase-like 1 (LOXL1) gene are strongly associate

193 ation between common genetic variants in the lysyl oxidase-like 1 (LOXL1) gene with pseudoexfoliation

194 Strong genetic risk is conferred by the lysyl oxidase-like 1 (LOXL1) gene, but additional comodu

195 sms (SNPs), rs3825942, and rs1048661, in the lysyl oxidase-like 1 gene (LOXL1).

196 trong familial association and recently, the lysyl oxidase-like 1 gene has been strongly associated w

197 However, the exact relationship between lysyl oxidase-like 1 polymorphisms and the development o

198 is an important risk factor for glaucoma and lysyl oxidase-like 1 polymorphisms are strongly associat

199 Lysyl oxidase-like 1 proved to be the major lysyl oxidas

200 LOXL1 (lysyl oxidase-like 1) has been identified as the major e

201 up of five members: lysyl oxidase (LOX) and lysyl oxidase-like 1-4 (LOXL1-LOXL4).

202 Human lysyl oxidase-like 2 (hLOXL2) is highly up-regulated in

203 This article investigates the role of lysyl oxidase-like 2 (LOXL-2) in the biology of HCC meta

204 essed the steady-state enzymatic activity of lysyl oxidase-like 2 (LOXL2) against the substrates 1,5-

205 derived 3D matrix system and identified anti-lysyl oxidase-like 2 (LOXL2) antibodies that alter the n

206 Lysyl oxidase-like 2 (LOXL2) catalyses collagen cross-li

207 Lysyl oxidase-like 2 (LOXL2) is a secreted enzyme that c

208 Lysyl oxidase-like 2 (LOXL2) is involved in a wide range

209 We previously described lysyl oxidase-like 2 (LOXL2), a member of the lysyl oxid

210 oxyphenolics required the presence of active lysyl oxidase-like 2 (LOXL2), thereby limiting effects t

211 show that an enzyme that crosslinks collagen-Lysyl oxidase-like 2 (Loxl2)-is essential for interstiti

212 Lysyl oxidase-like 2 (LOXL2)-mediated cross-linking of t

213 , crosslinking genes/enzymes (lysyl oxidase, lysyl oxidase-like 2-4, tissue transglutaminase-2), and

214 to be due to disruption of regulatory genes (lysyl oxidase-like and clusterin) that are involved in b

215 ic domains that provide for lysyl oxidase or lysyl oxidase-like enzyme activity; and more divergent p

216 Additionally, lysyl oxidase-like protein 3 expression was up-regulated

217 sors histone deacetylases 1 and 2 as well as lysyl oxidase-like protein 3 with Snail1 was impaired wh

218 The lysyl oxidase-like protein LOXL2 has been suggested to c

219 Lysyl oxidase-like-1 (LOXL1), a vital crosslinking enzym

220 identified a new role for the matrix enzyme lysyl oxidase-like-2 (LOXL2) in the creation and mainten

221 Lysyl oxidase-like-2 (LOXL2) induces tumor progression a

222 Lysyl oxidase-like-2 (LOXL2) is an enzyme secreted into

223 Among all lysyl oxidase family members, lysyl oxidase-like-2 (LOXL2) was identified as the isofo

224 accompanying intermolecular cross-linking by lysyl oxidase-mediated bonds, is vital to the structural

225 electively affects the extent and pattern of lysyl oxidase-mediated collagen cross-linking by sterica

226 ing as a potential contributor, we inhibited lysyl oxidase-mediated collagen cross-linking, which sig

227 trix compliance in vitro and by manipulating lysyl oxidase-mediated collagen crosslinking in vivo.

228 Consistently, reduction of lysyl oxidase-mediated collagen crosslinking prevented M

229 This suggests that lysyl oxidase-mediated cross-linking plays a significant

230 s interaction also increases the activity of lysyl oxidase.

231 ced angiogenesis via activation of Cu enzyme lysyl oxidase.

232 activation of PI3K/AKT, GSK3beta, Snail, and lysyl oxidase.

233 es proteolytic activation of the zymogen for lysyl oxidase.

234 collagens and collagen cross-linking enzyme lysyl oxidase.

235 increased aortic levels of tropoelastin and lysyl oxidase.

236 a property driven by the oxidative action of lysyl oxidase.

237 Lysyl oxidases (LOXs) are a family of copper-dependent o

238 Lysyl oxidases (LOXs) play a central role in extracellul

239 out the cement proteome, as well as multiple lysyl oxidases and peroxidases, establish homology with

240 Pharmacological inhibition of lysyl oxidases improved drug delivery in various tumor m

241 e deficiency of LOX in mice or inhibition of lysyl oxidases in turkeys and rats causes aortic dissect

242 nt loss of col8a1a function or inhibition of Lysyl oxidases with drugs during embryogenesis was suffi

243 e inhibitor of the enzymatic activity of all lysyl oxidases, is unable to abolish the LOXL2-induced i

244 trix (ECM) components and high expression of lysyl oxidases.

245 etylation and deacetylimination catalyzed by lysyl oxidases.

246 The lysyl oxidation product adipic semialdehyde (allysine, A

247 the synthesis and translocation of membrane lysyl-phosphatidylglycerol (an mprF-dependent function)

248 nthase (A-PGS) or by Lys-tRNA(Lys)-dependent lysyl-phosphatidylglycerol synthase (L-PGS) enables bact

249 In parallel, the structure of the related lysyl-phosphatidylglycerol-specific L-PGS domain from Ba

250 coding collagen prolyl (P4HA1 and P4HA2) and lysyl (PLOD2) hydroxylases.

251 e the activity of sirtuins toward additional lysyl posttranslational modifications, and show that sir

252 silicotic rats with N-acetyl-Seryl-Aspartyl-Lysyl-Proline (Ac-SDKP) inhibits myofibroblast different

253 i-fibrotic effect of N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) using proteomic profile analysis

254 antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP).

255 as the tetrapeptide N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP), play a significant role in contr

256 man carcinoma HEp2 cells show that the 15(2)-lysyl regioisomers accumulate the most within cells, and

257 rs three methyl groups to a highly conserved lysyl residue at position 115 in calmodulin (CaM).

258 residues of histone H3, with a dimethylated lysyl residue at position 4.

259 The probe design exploits a lysyl residue in EGFP that is essential for chromophore

260 glycolysis, are trimethylated at a conserved lysyl residue located close to the C terminus.

261 Lysyl residues 12, 233, 276, and 525 were previously rep

262 view will focus on N(epsilon)-acetylation of lysyl residues and how the posttranslational modificatio

263 uncharged and that at least one of the other lysyl residues be charged for catalysis.

264 nd 2-oxoglutarate-dependent hydroxylation of lysyl residues in arginine-serine-rich domains of RNA sp

265 deaminases that can modify the side chain of lysyl residues in collagen and elastin, thereby leading

266 at catalyze the site-specific methylation of lysyl residues in histone and non-histone proteins.

267 aches desthiobiotin to one or more conserved lysyl residues in the ATP-binding sites of protein kinas

268 diminished hydroxylation of the telopeptide lysyl residues involved in intermolecular cross-link for

269 structural data suggest how JMJD6 binds its lysyl residues such that it can catalyse C-5 hydroxylati

270 and both are capable of methylating multiple lysyl residues with broad sequence specificity.

271 st-translational hydroxylation of prolyl and lysyl residues, as catalyzed by 2-oxoglutarate (2OG)-dep

272 via hydroxylation) of N()-methylated histone lysyl residues, as well as hydroxylation of multiple oth

273 the enzyme that hydroxylates the telopeptide lysyl residues.

274 ed peptides which carry two or three epsilon-lysyl residues.

275 , the aminolysis reactivity of each modified lysyl side chain revealed a preference for reacting with

276 Reductive methylation of lysyl side-chain amines has been a successful tool in th

277 RNA, we discovered that the Escherichia coli lysyl tRNA synthetase was responsible for misacylating t

278 stem eliminated misacylation by the E. coli lysyl tRNA synthetase, and led to the development of a f

279 Here, we examine an N(epsilon)-acetyl-lysyl-tRNA synthetase (AcKRS), which is polyspecific (i.

280 Human lysyl-tRNA synthetase (hLysRS) is essential for aminoacy

281 Human lysyl-tRNA synthetase (hLysRS), the only cellular factor

282 is, p.Tyr173SerfsX7, and p.Ile302Met) in the lysyl-tRNA synthetase (KARS) gene in two patients from t

283 cing, we discovered genetic abnormalities in lysyl-tRNA synthetase (KARS).

284 e identified at highly conserved residues of lysyl-tRNA synthetase (KARS): the c.1129G>A (p.Asp377Asn

285 some cases may be driven by the presence of lysyl-tRNA synthetase (KRS) in the medium.

286 nscription primer via an interaction between lysyl-tRNA synthetase (LysRS) and the HIV-1 Gag polyprot

287 The alpha(2) homodimeric lysyl-tRNA synthetase (LysRS) is tightly bound in the MS

288 Moreover, similarly disrupted lysyl-tRNA synthetase (LysRS) proteins showed reduced en

289 s a mutation in the KARS gene, which encodes lysyl-tRNA synthetase (LysRS), a moonlight protein with

290 lciparum has shown that cladosporin inhibits lysyl-tRNA synthetase (PfKRS1).

291 jeK, encoding truncated homologs of class II lysyl-tRNA synthetase and of lysine-2,3-aminomutase, res

292 Purified E. coli RNA polymerase and lysyl-tRNA synthetase are both capable of adding such 5'

293 blem, Hoepfner et al. uncover the parasite's lysyl-tRNA synthetase as a druggable target.

294 Human lysyl-tRNA synthetase is bound to the multi-tRNA synthet

295 d a trans pQTL relationship between the KARS lysyl-tRNA synthetase locus and levels of the DIDO1 prot

296 nal modification with (R)-beta-lysine by the lysyl-tRNA synthetase paralog PoxA.

297 A putative lysyl-tRNA synthetase resistance gene was identified in

298 molar inhibitor of the Plasmodium falciparum lysyl-tRNA synthetase, and exhibits activity against bot

299 n the mammalian cells by S207-phosphorylated Lysyl-tRNA synthetase.

300 expression of SNAT2 in which seven putative lysyl-ubiquitination sites in the cytoplasmic N-terminal