ライフサイエンスコーパス: lysyl-tRNA synthetase

1 ein A) and LysN (anticodon binding domain of lysyl tRNA synthetase).

2 base pair reduces mischarging by the E. coli lysyl-tRNA synthetase.

3 he synthesis of asparaginyl-tRNA and a novel lysyl-tRNA synthetase.

4 n shown to contain an unrelated class I-type lysyl-tRNA synthetase.

5 rgdorferi contains a functional class I-type lysyl-tRNA synthetase.

6 (Trp)(CCA) to be aminoacylated by A.thaliana lysyl-tRNA synthetase.

7 n the mammalian cells by S207-phosphorylated Lysyl-tRNA synthetase.

8 RS1 and LysRS2, the two different M. barkeri lysyl-tRNA synthetases.

9 h lysine but is not closely related to known lysyl-tRNA synthetases.

10 bases indicated high homology to a family of lysyl-tRNA synthetases.

11 he amino acid level to archaeal class I-type lysyl-tRNA synthetases.

12 Lysyl-tRNA synthetase 1 (KARS1), an aminoacyl-tRNA synth

13 targeted the ATP-binding pocket of T. cruzi lysyl-tRNA synthetase 1 (KRS1).

14 Lysyl-tRNA synthetase, a class II enzyme, edits homocyst

15 We examined lysyl-tRNA synthetase, a close structural homologue of t

16 Here, we examine an N(epsilon)-acetyl-lysyl-tRNA synthetase (AcKRS), which is polyspecific (i.

17 o the production of a protein with canonical lysyl-tRNA synthetase activity in vitro.

18 Lysyl-tRNA synthetase aminoacylates CoA-SH with lysine,

19 69 base pair to G4:C69 and overproduction of lysyl-tRNA synthetase and methionyl-tRNA transformylase

20 jeK, encoding truncated homologs of class II lysyl-tRNA synthetase and of lysine-2,3-aminomutase, res

21 r results on recognition of tRNAs by E. coli lysyl-tRNA synthetase and on competition in cells among

22 Two proteins, lysyl-tRNA synthetase and translocon-associated protein

23 stem eliminated misacylation by the E. coli lysyl tRNA synthetase, and led to the development of a f

24 molar inhibitor of the Plasmodium falciparum lysyl-tRNA synthetase, and exhibits activity against bot

25 Purified E. coli RNA polymerase and lysyl-tRNA synthetase are both capable of adding such 5'

26 In bacteria and eukarya, all known lysyl-tRNA synthetases are subclass IIc-type aminoacyl-t

27 blem, Hoepfner et al. uncover the parasite's lysyl-tRNA synthetase as a druggable target.

28 The Arabidopsis thaliana lysyl tRNA synthetase (AtKRS) structurally and functiona

29 ination factor Rho, bacterial and eukaryotic lysyl-tRNA synthetases, bacteriophage T4 endonuclease VI

30 Thus, isoleucyl-, valyl-, and lysyl-tRNA synthetases behave as aminoacyl-S-CoA synthet

31 , our analysis points to the extant forms of lysyl-tRNA synthetase being preceded in evolution by the

32 significant similarity to any class II-type lysyl-tRNA synthetase could be detected.

33 lso encode G73, the motif 2 loop sequence of lysyl-tRNA synthetase differs at multiple positions from

34 r, the capacity of tRNA3Lys to interact with lysyl-tRNA synthetase does not entirely explain the enha

35 They are synthesized by lysyl-tRNA synthetases (EC 6.1.1.6), a group of enzymes

36 lysis of B. burgdorferi mRNA showed that the lysyl-tRNA synthetase-encoding gene is highly expressed,

37 Lysyl-tRNA synthetase from Escherichia coli belongs to t

38 The genomic lysyl-tRNA synthetase gene consisted of 15 exons.

39 tely 30%, of the mature transcripts from the lysyl-tRNA synthetase gene.

40 gene lies immediately adjacent to the cKARS (lysyl-tRNA synthetase) gene with the two genes in a head

41 Expression of the two lysyl-tRNA synthetase-green fluorescent protein gene fus

42 of fully modified cellular tRNALys3 by human lysyl-tRNA synthetase (h-LysRS).

43 Two cDNAs encoding human lysyl-tRNA synthetase have been identified.

44 hydrolyze lysyl-adenylate generated by human lysyl-tRNA synthetase (hLysRS) by proceeding through an

45 Human lysyl-tRNA synthetase (hLysRS) is essential for aminoacy

46 Human lysyl-tRNA synthetase (hLysRS), the only cellular factor

47 f the anticodon in tRNA recognition by human lysyl-tRNA synthetase (hLysRS).

48 The detection of an archaeal-type lysyl-tRNA synthetase in B. burgdorferi and other pathog

49 udies have demonstrated that the presence of lysyl-tRNA synthetase in HIV-1 virions might account for

50 this knowledge gap, a diverse set of potent lysyl-tRNA synthetase inhibitors was profiled to identif

51 Lysyl-tRNA synthetase is a member of the class II aminoa

52 Human lysyl-tRNA synthetase is bound to the multi-tRNA synthet

53 ases, we report here that the class II human lysyl-tRNA synthetase is relatively insensitive to the n

54 is, p.Tyr173SerfsX7, and p.Ile302Met) in the lysyl-tRNA synthetase (KARS) gene in two patients from t

55 Lysyl-tRNA synthetase (KARS), an enzyme required for pro

56 cing, we discovered genetic abnormalities in lysyl-tRNA synthetase (KARS).

57 e identified at highly conserved residues of lysyl-tRNA synthetase (KARS): the c.1129G>A (p.Asp377Asn

58 some cases may be driven by the presence of lysyl-tRNA synthetase (KRS) in the medium.

59 an methionyl-tRNA synthetase (MRS) and human lysyl-tRNA synthetase (KRS) were expressed in human-deri

60 d a trans pQTL relationship between the KARS lysyl-tRNA synthetase locus and levels of the DIDO1 prot

61 inhibition of the Mycobacterium tuberculosis lysyl tRNA synthetase (LysRS).

62 Yeast two-hybrid screens suggested that lysyl-tRNA synthetase (LysRS) also associates with LeuRS

63 s has been developed against M. tuberculosis lysyl-tRNA synthetase (LysRS) and cellular studies suppo

64 nscription primer via an interaction between lysyl-tRNA synthetase (LysRS) and the HIV-1 Gag polyprot

65 f the transcription factors MITF or USF2 and lysyl-tRNA synthetase (LysRS) are associated with human

66 into two unrelated structural classes, with lysyl-tRNA synthetase (LysRS) being the only enzyme repr

67 previously shown that the essential protein lysyl-tRNA synthetase (LysRS) exists in two unrelated fo

68 Human lysyl-tRNA synthetase (LysRS) is also specifically packa

69 unrelated aminoacyl-tRNA synthetase classes, lysyl-tRNA synthetase (LysRS) is the only example known

70 The alpha(2) homodimeric lysyl-tRNA synthetase (LysRS) is tightly bound in the MS

71 Moreover, similarly disrupted lysyl-tRNA synthetase (LysRS) proteins showed reduced en

72 Lysyl-tRNA synthetase (LysRS), a class II enzyme whose m

73 s a mutation in the KARS gene, which encodes lysyl-tRNA synthetase (LysRS), a moonlight protein with

74 s a mutation in the KARS gene, which encodes lysyl-tRNA synthetase (LysRS), a moonlight protein with

75 Gag and GagPol, as well as host cell factor lysyl-tRNA synthetase (LysRS), are required for specific

76 horamidates and lysyl-adenylate generated by lysyl-tRNA synthetase (LysRS).

77 res lysyl-tRNA(Lys), which is synthesized by lysyl-tRNA synthetase (LysRS).

78 tion in the C. capitata lysine--tRNA ligase (Lysyl-tRNA synthetase, LysRS) gene responsible for the t

79 Alternatively, class I and class II lysyl-tRNA synthetases (LysRS1 and LysRS2) together form

80 Lysyl-tRNA synthetases (LysRSs) are unique amongst the a

81 The crystal structure of the constitutive lysyl-tRNA synthetase (LysS) from Escherichia coli has b

82 Crystals of the thermo-inducible E. coli lysyl-tRNA synthetase LysU which diffract to 2.1 A resol

83 This difference between the lysyl-tRNA synthetases of spirochetes and their hosts ma

84 nal modification with (R)-beta-lysine by the lysyl-tRNA synthetase paralog PoxA.

85 lciparum has shown that cladosporin inhibits lysyl-tRNA synthetase (PfKRS1).

86 A putative lysyl-tRNA synthetase resistance gene was identified in

87 the sequence of the loop of motif 2 of human lysyl-tRNA synthetase specifies a structural variation t

88 RNA, we discovered that the Escherichia coli lysyl tRNA synthetase was responsible for misacylating t

89 syl-AMP generated by either E. coli or human lysyl-tRNA synthetase were partially transferable by C-t

90 Nonautoantigenic aspartyl-tRNA and lysyl-tRNA synthetases were not chemotactic.

91 ural classes, the only known exception being lysyl-tRNA synthetase which exists in both classes I (Ly