ライフサイエンスコーパス: m-tyrosine

1 the abnormal tyrosine isomer meta-tyrosine (m-tyrosine).

2 ion, suggesting that TATN-1 also metabolizes m-tyrosine.

3 zes phenylalanine residues to o-tyrosine and m-tyrosine.

4 ucture could diminish the adverse effects of m-tyrosine.

5 lity, and shortened lifespan when exposed to m-tyrosine.

6 Using [(18)F]Fluoro-m-tyrosine ([(18)F]FMT) PET imaging to measure catechola

7 We used [(18)F]Fluoro-m-tyrosine ([(18)F]FMT) PET imaging to measure serotonin

8 thesis capacity (Ki) using 6-[(18)F]fluoro-l-m-tyrosine ([(18)F]FMT; a substrate for aromatic amino a

9 fluoro-L-m-tyrosine (6-FMT), 2-[18F]fluoro-L-m-tyrosine (2-FMT) and 6-[18F]fluoro-fluoromethylene-DL-

10 (2-FMT) and 6-[18F]fluoro-fluoromethylene-DL-m-tyrosine (6-F-FMMT), were prepared via electrophilic r

11 he three m-tyrosine analogs, 6-[18F]fluoro-L-m-tyrosine (6-FMT), 2-[18F]fluoro-L-m-tyrosine (2-FMT) a

12 t are resistant to the phytotoxic amino acid m-tyrosine, a structural analog of phenylalanine.

13 Fluorinated m-tyrosine analogs were evaluated as PET imaging agents

14 The three m-tyrosine analogs, 6-[18F]fluoro-L-m-tyrosine (6-FMT),

15 Consistent with a toxic effect of m-tyrosine and a protective function of TATN-1, tatn-1 m

16 the intravenous injection of [18F]6-fluoro-L-m-tyrosine and compared sampled blood time-activity curv

17 s to 6-[(18)F]fluoro-L-DOPA, 6-[(18)F]fluoro-m-tyrosine, and the translocator protein (TSPO) PET liga

18 ted and identified the nonprotein amino acid m-tyrosine as the major active component.

19 The discovery of m-tyrosine, as well as a further understanding of its mo

20 1], the anti-Parkinson (+/-)-(E)-2,3-methano-m-tyrosine [(+/-)-(E)-2], and the natural product (+/-)-

21 We show that m-tyrosine exposure results in growth inhibition for a w

22 m-Tyrosine fell from 4.24+/-0.99 to 4.03+/-0.97 ng/mL (P

23 6-[(18)F]Fluoro-m-tyrosine (FMT) is a positron emission tomography (PET)

24 mography (PET) radiotracer 6-[(18)F]fluoro-l-m-tyrosine (FMT) is a substrate of the dopamine-synthesi

25 The tracer 6-[18F]fluoro-L-m-tyrosine (FMT) was studied with regard to its biochemi

26 mine (DA) metabolism tracer, [18F]6-fluoro-L-m-tyrosine (FMT) were used to evaluate the relationship

27 The PET ligand was 6-[18F]fluoro-L-m-tyrosine (FMT), imaged prior to, and at two intervals

28 nd the DA metabolism tracer, 6-[18F]fluoro-L-m-tyrosine (FMT), indicating that both are good methods

29 FDG, 6-[18F]fluoro-L-m-tyrosine (FmT), or its major metabolite, 6-[18F]fluoro

30 croPET imaging with the tracer [(18)F]fluoro-m-tyrosine (FMT), the recovery of enzyme activity after

31 y affect cells, suggesting a direct role for m-tyrosine in oxidative stress effects.

32 levels of o, o'-dityrosine, o-tyrosine, and m-tyrosine in proteins, lipoproteins, and tissue, using

33 m-Tyrosine inhibition of A. thaliana root growth is coun

34 Biochemical assays revealed that m-tyrosine is a substrate for TATN-1-mediated deaminatio

35 m-Tyrosine is significantly more phytotoxic than its str

36 m-Tyrosine levels are commonly used as a biomarker of ox

37 Its parent compound, L-m-tyrosine (LMT) induces behavioral effects in rodents v

38 t C14 and C15, and the hydroxyl group of the m-tyrosine (m-Tyr) residue as key contributors to compou

39 sferase in the oxidative stress response via m-tyrosine metabolism.

40 s of macrocyclic HCV inhibitors started from m-tyrosine methyl ester.

41 rkers of oxidative stress (e.g., o-tyrosine, m-tyrosine, nitrotyrosine, dityrosine, glutathione disul

42 tric synthesis of L-alpha-vinyl analogues of m-tyrosine, ornithine, and lysine, known time-dependent

43 compound optimization identified the valine-m-tyrosine-piperazic acid tripeptide (Val-m-Tyr-Pip) in

44 Arabidopsis thaliana showed incorporation of m-tyrosine, suggesting this as a possible mechanism of p

45 We used PET with 6-[(18)F]fluoro-L-m-tyrosine to quantify dopamine synthesis capacity in vi

46 uppresses the adverse phenotypes observed in m-tyrosine-treated tatn-1 mutant worms.

47 Using the PET tracer 6-[(18)F]fluoro-l-m-tyrosine, we found strong support for upregulated stri

48 striking contrast, levels of o-tyrosine and m-tyrosine were not elevated in LDL isolated from athero

49 e, and 2- and 3-hydroxyphenylalanine (o- and m-tyrosine) were inactive.