ライフサイエンスコーパス: mRNA degradation

1 geting them for translational repression and mRNA degradation.

2 identifies samples with different levels of mRNA degradation.

3 the initial and often rate-limiting step in mRNA degradation.

4 enylation activity and is required for MHC-I mRNA degradation.

5 ts down translation initiation and activates mRNA degradation.

6 t bind the mRNAs of some viruses, leading to mRNA degradation.

7 o combat oxidative stress by modulating cysB mRNA degradation.

8 e in hydrolyzing the cap structure following mRNA degradation.

9 acts independently in the regulation of IL-6 mRNA degradation.

10 ression of protein synthesis and ER-specific mRNA degradation.

11 ing against an important cytoplasmic role in mRNA degradation.

12 s (17-25 nt) that control translation and/or mRNA degradation.

13 utput of target genes; they act by promoting mRNA degradation.

14 dies), which concentrate factors involved in mRNA degradation.

15 eased proximity of Ago2 to nascent chain and mRNA degradation.

16 -exosome interaction, which is important for mRNA degradation.

17 mily 2 (YTHDF2) 'reader' protein to regulate mRNA degradation.

18 SLBP from the histone mRNA prior to histone mRNA degradation.

19 c binding relationships for co-regulation of mRNA degradation.

20 inhibition is the primary event required for mRNA degradation.

21 silence host gene expression via widespread mRNA degradation.

22 involved in mRNA and protein storage and/or mRNA degradation.

23 dation is temporally correlated with histone mRNA degradation.

24 oth robustly inhibit translation and promote mRNA degradation.

25 tivates both Xbp1 splicing and IRE1-mediated mRNA degradation.

26 he endonuclease most important for governing mRNA degradation.

27 yme 1 (DCP1), a marker of P-bodies; sites of mRNA degradation.

28 ycomb repressive complex 2 and initiation of mRNA degradation.

29 e characterize a novel role for ubiquitin in mRNA degradation.

30 ifferentiation, GRHL3, at low levels through mRNA degradation.

31 n part as a consequence of nonsense-mediated mRNA degradation.

32 ng the antiviral response by promoting IRF-7 mRNA degradation.

33 nd provide a link between ubiquitination and mRNA degradation.

34 lase leading to translational inhibition and mRNA degradation.

35 translated region (3'-UTR), leading to Keap1 mRNA degradation.

36 idine-rich elements in the p19 3'UTR and p19 mRNA degradation.

37 ylation controls AUF1 levels to modulate ARE mRNA degradation.

38 completely abolishes IFN-gamma-mediated p19 mRNA degradation.

39 prevent ribosome binding causing accelerated mRNA degradation.

40 ued to examine the contributions of Hsp27 to mRNA degradation.

41 'UTRs, followed by translation repression or mRNA degradation.

42 tween components involved in translation and mRNA degradation.

43 at controls the subsequent sequence-specific mRNA degradation.

44 Rs) and mediate translational repression and mRNA degradation.

45 K2 phosphorylates PARN, blocking Gadd45alpha mRNA degradation.

46 nor Delta12 significantly enhanced reporter mRNA degradation.

47 gregated, translationally silenced mRNAs and mRNA degradation.

48 bind 40S ribosomal subunits or promote host mRNA degradation.

49 ted in translational repression, but not CIS mRNA degradation.

50 f the Lsm1-7 complex involved in cytoplasmic mRNA degradation.

51 of TNRC6B, a gene involved in miRNA-mediated mRNA degradation.

52 d mouse, we uncover a requirement for mutant mRNA degradation.

53 protein synthesis in infected cells through mRNA degradation.

54 cific manner via translational inhibition or mRNA degradation.

55 ly and temporally with the onset of maternal mRNA degradation.

56 PABP which sequesters the A-tail and impedes mRNA degradation.

57 e inhibits MSY2 phosphorylation and prevents mRNA degradation.

58 from cytoplasmic processing bodies, sites of mRNA degradation.

59 n to be involved in transcription as well as mRNA degradation.

60 ARE-binding protein essential for rapid ARE-mRNA degradation.

61 portant process in the control of eukaryotic mRNA degradation.

62 CD44-v mRNA levels was not due to increased mRNA degradation.

63 was caused by increased rates of involucrin mRNA degradation.

64 eferentially localized to P-bodies, sites of mRNA degradation.

65 ribonucleoprotein (mRNP) that promotes 5'-3' mRNA degradation.

66 suppresses IL-27 production by promoting p28 mRNA degradation.

67 iated mRNAs results in ribosome stalling and mRNA degradation.

68 omeostasis and signal-dependent induction of mRNA degradation.

69 liferation by promoting cell cycle inhibitor mRNA degradation.

70 discovery of additional key factors in human mRNA degradation.

71 at RRP6 was required for CELF1-mediated Cx43 mRNA degradation.

72 and inducing translational repression and/or mRNA degradation.

73 , resulting in suppression of translation or mRNA degradation.

74 t with membranes to facilitate regulation of mRNA degradation.

75 ormed, suggesting that RNaseH is involved in mRNA degradation.

76 e daily transfection was required because of mRNA degradation.

77 egulated by inflammatory stimuli, to promote mRNA degradation.

78 ft from protein translation to NMD-dependent mRNA degradation.

79 esses through gene expression suppression or mRNA degradation.

80 PIP4 act independently in regulation of IL-6 mRNA degradation.

81 l suppression or induction of messenger RNA (mRNA) degradation.

82 screte miR effector mechanisms: (1) for p21, mRNA degradation; (2) for Bim, translational inhibition.

83 lter protein expression through differential mRNA degradation, a regulatory mechanism that may allow

84 Furthermore, like SARS-CoV nsp1, the mRNA degradation activity of MERS-CoV nsp1, most probabl

85 s polyC motif is required and sufficient for mRNA degradation after fertilization.

86 regate level, target binding leads mainly to mRNA degradation, although we also observed some degree

87 This was partly due to increased TNF mRNA degradation, an effect that was reduced by ZFP36 si

88 , the DF paralogs act redundantly to mediate mRNA degradation and cellular differentiation.

89 data revealed that nsp1 indeed promoted host mRNA degradation and contributed to host protein transla

90 et sites on the 3'-UTR of MITF mRNA, causing mRNA degradation and decreased expression and activity o

91 tigated the mechanism of CELF1-mediated Cx43 mRNA degradation and determined whether elevated CELF1 e

92 (miRNAs), small noncoding RNAs that promote mRNA degradation and inhibit mRNA translation, have been

93 tively regulate gene expression by promoting mRNA degradation and inhibiting mRNA translation.

94 press host gene expression by promoting host mRNA degradation and inhibiting translation.

95 Lsm1 is required for histone mRNA degradation and is present in a complex containing

96 cations for the interplay of translation and mRNA degradation and models of gene regulation by small

97 bonuclease Xrn1 catalyze successive steps in mRNA degradation and prevent double-stranded RNA (dsRNA)

98 ted evidence for a role of Y14 in regulating mRNA degradation and processing body formation and reinf

99 to understand the role of RNase Y in global mRNA degradation and processing.

100 enoxacin (Penetrex) enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogeno

101 riched in cytoplasmic P bodies, the sites of mRNA degradation and storage in yeast and mammalian cell

102 This identifies bulk mRNA degradation and the resistance of antiviral mRNAs a

103 sion might act through TTP by increasing p19 mRNA degradation and therefore IL-23 inhibition.

104 The control of mRNA degradation and translation are important for the r

105 esses host gene expression by promoting host mRNA degradation and translation inhibition.

106 ol of ATP-binding cassette (ABC)-transporter mRNA degradation and translation into proteins.

107 24-3p regulates HO-1 expression through both mRNA degradation and translation repression.

108 dose-dependent manner through miRNA-induced mRNA degradation and translation repression.

109 Puf proteins regulate mRNA degradation and translation through interactions wi

110 MicroRNAs (miRNAs), which direct mRNA degradation and translational inhibition, influence

111 untranslated region of mRNA, which leads to mRNA degradation and translational repression.

112 The host mRNA degradation and translational suppression activitie

113 ratures, the stem-loop unfolds, allowing for mRNA degradation and turning off expression.

114 tant form of TTP was sufficient for enhanced mRNA degradation and underexpression of inflammatory med

115 amentally different set of ribonucleases for mRNA degradation and whether sRNAs can regulate the acti

116 mRNA because of the shorter 3'UTR, and thus, mRNA degradation and/or repression on protein translatio

117 ments in 3'-untranslated regions to regulate mRNA degradation and/or translation.

118 s that reduce expression of proteins through mRNA degradation and/or translational silencing.

119 MicroRNAs (miRNAs) induce messenger RNA (mRNA) degradation and repress mRNA translation.

120 nal inhibition of miR-221 prevented TNFalpha mRNA degradation, and blocking miR-579 and miR-125b prec

121 nd sustains SOCS1 induction by promoting Fto mRNA degradation, and forced FTO expression in macrophag

122 repressing gene transcription, accelerating mRNA degradation, and impeding pre-ALAS-1 mitochondrial

123 oskeleton, ribosome maturation, translation, mRNA degradation, and more generally in precluding a pot

124 anging the rate of transcription initiation, mRNA degradation, and mRNA translation.

125 ssion at the levels of alternative splicing, mRNA degradation, and translation.

126 Translational repression and mRNA degradation are critical mechanisms of posttranscri

127 However, the processes of human pre-mRNA degradation are not well characterised in the human

128 icularly during stress where translation and mRNA degradation are reprogrammed to stabilize bulk mRNA

129 Translation and messenger RNA (mRNA) degradation are important sites of gene regulation

130 n dendrites and highlight activity-dependent mRNA degradation as a regulatory process involved in syn

131 its target sites on the MITF 3'-UTR, causing mRNA degradation as well as decreased expression and act

132 Both the promoter luciferase assay and mRNA degradation assay clearly showed that depletion of

133 degradation status of RNA the R(amp) mapped mRNA degradation better.

134 go-2 PAZ domain and can localize into GW-182 mRNA-degradation bodies (GW-bodies).

135 he cytoplasm, for translation inhibition and mRNA degradation but spared exogenous mRNAs introduced d

136 their downregulations are not controlled by mRNA degradation but through different posttranslational

137 by inhibiting mRNA translation and promoting mRNA degradation, but little is known of their potential

138 e dynamic cytoplasmic structures involved in mRNA degradation, but the mechanism that governs their f

139 R and AUF1 and that polyamines modulate JunD mRNA degradation by altering the competitive binding of

140 icroRNAs inhibit mRNA translation or promote mRNA degradation by binding complementary sequences in 3

141 CELF1 mediated Cx43 mRNA degradation by binding the UG-rich element in the 3

142 es demonstrate that FGF signals use targeted mRNA degradation by Brf1 to enable rapid posttranscripti

143 Rather, we found that Eap1p accelerates mRNA degradation by promoting decapping, and the ability

144 iple, biologically relevant factors, such as mRNA degradation by RNase enzymes, different phases of t

145 ng transcription factors and protection from mRNA degradation by RNase.

146 time-delay model of protein translation and mRNA degradation by systematically reducing a detailed m

147 ls, epigenetic status, splicing kinetics and mRNA degradation can each contribute to changes in the m

148 dicted to further expand the capacity of the mRNA degradation code by coupling it to dynamic events e

149 ntal gene expression is shaped by a complex 'mRNA degradation code' with high information capacity.

150 protein that recruits the exosome-containing mRNA degradation complex to mRNAs coding for cellular pr

151 tion by monocytes depends heavily upon rapid mRNA degradation, conferred by 3' untranslated region-lo

152 ut not the Dis3L2 exonuclease, slows histone mRNA degradation consistent with 3' to 5' degradation by

153 eas decapping factors are recruited only for mRNA degradation, consistent with decapping being a rate

154 , our study provides evidence for widespread mRNA degradation control in numerous biological processe

155 nstrate that the efficiency of ARE-dependent mRNA degradation declines in the neural lineage because

156 senger RNA (mRNA) to induce its degradation; mRNA degradation depleted occludin from enterocytes, res

157 ict antiviral responses by accelerating host mRNA degradation during poxvirus infection.

158 ze distributions are, in addition, shaped by mRNA degradation during transcription bursts.

159 nitiation factors, molecular chaperones, and mRNA degradation enzymes to the ARE for mRNA destruction

160 However, the mechanism of host mRNA degradation, especially where and how PA-X targets

161 esponse is mediated in part through cytokine mRNA degradation facilitated by RNA-binding proteins, in

162 mutant could still interact with the NMD and mRNA degradation factors and retained partial NMD activi

163 the strong requirement for general 5' to 3' mRNA degradation factors Dcp1, Dcp2, and Xrn1 in Ty1 ret

164 mer, Y14/Magoh, specifically associates with mRNA-degradation factors, including the mRNA-decapping c

165 ocessing bodies, perhaps by sequestering the mRNA-degradation factors.

166 to explore the links between RNA binding and mRNA degradation for both AUF1 and Argonaute 2 (AGO2), w

167 ddition, mapping and sequence analysis of an mRNA degradation fragment that accumulates in the absenc

168 h enzymes results in the appearance of novel mRNA degradation fragments.

169 The mRNA degradation function also ensures rapid cell prolif

170 ves mRNA at ACA sequences, leading to global mRNA degradation, growth arrest, and death.

171 ay and we suggest that the 5'-3' polarity of mRNA degradation has evolved to ensure that the last tra

172 t mechanism whereby polyamines regulate JunD mRNA degradation has not been elucidated.

173 clease (PARN) deadenylase in miRNA-dependent mRNA degradation has not been elucidated.

174 5' UTR of the translating mRNA and promoting mRNA degradation in a translation-dependent manner.

175 requirements are observed for RppH-dependent mRNA degradation in B. subtilis cells.

176 The molecular mechanisms for target mRNA degradation in Caenorhabditis elegans undergoing RN

177 t revealed a previously unrecognized role of mRNA degradation in cardiomyocyte growth, and suggested

178 tion, we have investigated the importance of mRNA degradation in controlling gene expression downstre

179 ng that there is not a general activation of mRNA degradation in dendrites.

180 can have a major impact on 5' end-dependent mRNA degradation in E. coli and suggest a possible seque

181 y, this master regulator of 5'-end-dependent mRNA degradation in E. coli not only catalyses a process

182 are also manifested during 5'-end-dependent mRNA degradation in E. coli.

183 characterized pathway for the initiation of mRNA degradation in Escherichia coli involves the remova

184 deadenylation, is the rate-limiting step of mRNA degradation in eukaryotic cells.

185 ate-limiting step in the general cytoplasmic mRNA degradation in eukaryotic cells.

186 st rate-limiting step in general cytoplasmic mRNA degradation in eukaryotic cells.

187 for tumor necrosis factor alpha (TNF-alpha) mRNA degradation in monocytes.

188 mRNA decapping is a late step in NMD-related mRNA degradation in plants.

189 sRNAs can directly modulate mRNA degradation in Proteobacteria without interfering w

190 ding the transcription factor Xbp1, mediates mRNA degradation in response to ER stress through a path

191 To determine the role of endonucleases in mRNA degradation in Saccharomyces cerevisiae, we mapped

192 pressing constitutively active forms induces mRNA degradation in the absence of maturation and phosph

193 tested and shows negligible correlation with mRNA degradation in the adjacent samples.

194 nown to mediate translational repression and mRNA degradation in the cytoplasm.

195 ere, we examine the consequences of enhanced mRNA degradation in the galactose utilization network of

196 aminergic oxidative injury by promoting NOX2 mRNA degradation in the MPP(+) /MPTP model of PD, sugges

197 oligonucleotides (ASOs) are known to trigger mRNA degradation in the nucleus via an RNase H-dependent

198 Using microarrays, we also measured relative mRNA degradation in the presence and absence of ER stres

199 ression leads to poly(A) tail shortening and mRNA degradation in tissue culture cells, and we detect

200 n and its orthologs regulate translation and mRNA degradation in yeast, C. elegans, D. melanogaster,

201 long-standing assumption that messenger RNA (mRNA) degradation in Escherichia coli begins with endonu

202 d betacoronaviruses can result in widespread mRNA degradation, in each case initiated predominantly b

203 olling mRNA processing and the regulation of mRNA degradation, including the role of microRNAs and RN

204 nding of the molecular mechanisms underlying mRNA degradation indicates that specific mRNA degradatio

205 d that profiles the genome-wide abundance of mRNA degradation intermediates by virtue of their 5'-pho

206 Sequencing of mRNA degradation intermediates revealed that the complet

207 tion of an oligonucleotide to the 5'P end of mRNA degradation intermediates, followed by depletion of

208 By sequencing the ends of 5' phosphorylated mRNA degradation intermediates, we obtain a genome-wide

209 of widespread cytoplasmic polyadenylation of mRNA degradation intermediates.

210 Co-translational mRNA degradation is a widespread process in which 5'-3'

211 mRNA degradation is an important mechanism for controlli

212 press translation of manY and manZ even when mRNA degradation is blocked.

213 , but the role of NMD on yeast unspliced pre-mRNA degradation is controversial.

214 However, much mRNA degradation is cytoplasmic such that mRNA nuclear e

215 Rapid mRNA degradation is facilitated by the preference of bot

216 Cotranslational mRNA degradation is initiated by decapping and proceeds

217 at it could represent a major means by which mRNA degradation is initiated in E. coli and other organ

218 mRNA degradation is often initiated by deadenylation, wh

219 ation specific transcription factors through mRNA degradation is required for progenitor cell mainten

220 We report that the initial step in histone mRNA degradation is the addition of uridines to the 3' e

221 zymes that function in normal mRNA decay and mRNA degradation is widely thought to occur when mRNAs a

222 downregulation of CAR protein and mRNA (via mRNA degradation); it sensitized doxorubicin-resistant c

223 6L1, bound to HIF1A 3'UTR and mediated HIF1A mRNA degradation, leading to reduced expression of HIF1A

224 ntify Stm1 as an additional component of the mRNA degradation machinery and suggest a possible connec

225 interaction resulted in the inability of the mRNA degradation machinery to sense codon optimality.

226 contain some translation repressors and the mRNA degradation machinery, and in stress granules, whic

227 ating mRNA, translation repressors, and some mRNA degradation machinery.

228 ctors and heat shock proteins to attract the mRNA degradation machinery.

229 A to form mRNP complexes that evade cellular mRNA degradation machinery.

230 s and the general translation repression and mRNA degradation machinery.

231 e in the context of viral-induced widespread mRNA degradation may influence the outcome of viral infe

232 The selectivity of this mRNA degradation mechanism relies on KSRP recognition of

233 ic cells, various translation inhibition and mRNA degradation mechanisms congregate in cytoplasmic pr

234 is repression was accompanied by accelerated mRNA degradation mediated by the major deadenylase, Ccr4

235 mRNA stability and high affinity HuD-target mRNA degradation mediates the bidirectional expression o

236 tic cells, as transcription, translation and mRNA degradation mostly occur in distinct functional com

237 with ribosomes in vivo and facilitated rapid mRNA degradation near the 5' end via cleavage at AAA lys

238 mutant (nsp1-mt) that neither promoted host mRNA degradation nor suppressed host protein synthesis i

239 Arc mRNA degradation occurs throughout the dendrite and requ

240 assays reveal that QKI-7 binds and promotes mRNA degradation of downstream targets CD144, Neuroligin

241 ation c.6599-20A>T causes type 1 VWD through mRNA degradation of exon 38 skipping transcripts.

242 S protein or mRNA level (consistent with the mRNA degradation of nNOS by miR-31).

243 YS) translational repression and accelerated mRNA degradation of nNOS leading to a profound reduction

244 The initiation of mRNA degradation often requires deprotection of its 5' e

245 trolling gene expression, either by inducing mRNA degradation or by blocking mRNA translation.

246 hundreds of target genes, leading either to mRNA degradation or suppression of translation.

247 lay important regulatory roles in modulating mRNA degradation or translational efficiency.

248 ite-specific cleavage and non-cleavage-based mRNA degradation or translational repression.

249 complementary target mRNA, thereby mediating mRNA degradation or translational repression.

250 ) are small regulatory molecules that act by mRNA degradation or via translational repression.

251 ome inhibitors rescued MEX-3C-mediated MHC-I mRNA degradation, our findings suggest a new non-proteol

252 Ago2 is localized in mRNA-degradation P-bodies analogous to those that functi

253 initiation factors over ~16 min and provoked mRNA degradation, particularly for translation-related f

254 3, KLF4, and ZNF750 are degraded through the mRNA degradation pathway, which prevents premature diffe

255 shutoff factors have converged upon a common mRNA degradation pathway.

256 difications regulating the decapping step in mRNA degradation pathways are poorly defined.

257 There are two known mRNA degradation pathways, 3' to 5' and 5' to 3'.

258 There are two mRNA degradation pathways: 3' to 5' and 5' to 3'.

259 GFP messenger RNA (mRNA) levels, mRNA degradation patterns, and bacterial growth rates al

260 information on mechanisms that may regulate mRNA degradation, possibly on short timescales.

261 R-dependent transcription and enhancement of mRNA degradation, possibly via regulated IRE1-dependent

262 slational quality control, in which specific mRNA degradation preemptively regulates aberrant protein

263 ion of cellular proteins is due to an active mRNA degradation process.

264 An important route for mRNA degradation produces uncapped mRNAs, and this decay

265 e three proteins act in association with the mRNA degradation protein RNaseY (Rny) to destabilize the

266 des its transcripts through association with mRNA degradation proteins.

267 ing mRNA degradation indicates that specific mRNA degradation rates are primarily encoded within the

268 mRNA degradation represents a critical regulated step in

269 NAs in which AUF1 affects their decay rates, mRNA degradation requires AGO2.

270 is that is compensated by down-regulation of mRNA degradation, resulting in mRNA level buffering.

271 inding activity and, thereby, enhancement of mRNA degradation seems to be the common denominator of m

272 he Drosophila Elav protein family that binds mRNA degradation sequences and prevents RNase-mediated d

273 tructures on mRNAs that is also sensitive to mRNA degradation, so uncapped or degraded mRNAs can be d

274 ess protein expression by promoting specific mRNA degradation steps in addition to or in lieu of inhi

275 Furthermore, RDE-11 is required for mRNA degradation subsequent to target engagement.

276 n of No-go decay factors also slowed histone mRNA degradation, suggesting a role in removing ribosome

277 translation repression during transport, and mRNA degradation suggests the hypothesis that an additio

278 iption factor, an inducer of p21, as a novel mRNA degradation target of CNOT3 in non-small cell lung

279 c competition between protein elongation and mRNA degradation that is a central feature of the physio

280 rther amplified by a decrease in the rate of mRNA degradation, the latter being regulated only by EGF

281 binding effects of the RNA helicase MOV10 on mRNA degradation, the potentially different ADAR1 bindin

282 istence of a 5' end-independent mechanism of mRNA degradation, the relative simplicity of the require

283 a truncated subunit, or more likely, trigger mRNA degradation through nonsense-mediated mRNA decay (N

284 The physiological importance of mRNA degradation through the CCR4-NOT deadenylase has re

285 t the translation level with minor effect on mRNA degradation, through binding to the coding regions

286 lly bound to the 3'UTRs of these targets for mRNA degradation, thus suppressing their expression.

287 ellular domains and kinase activity, through mRNA degradation to promote immunity.

288 cellular processes, including messenger RNA (mRNA) degradation, translational repression, and transcr

289 imultaneously, we find that that accelerated mRNA degradation underlies the rapid clearing of a subse

290 s transcriptional activity and mediating its mRNA degradation via miRNA.

291 ulated by feedback control of messenger RNA (mRNA) degradation via an unknown mechanism.

292 as P-bodies during stress did not occur, and mRNA degradation was heterogeneously distributed in the

293 D to block new mRNA synthesis showed that AR mRNA degradation was increased.

294 of gene regulation, splicing, elongation and mRNA degradation were estimated from experimental data o

295 regulating gene expression is messenger RNA (mRNA) degradation, which is initiated by poly(A) tail sh

296 h reduced affinity for the MCP, which allows mRNA degradation while preserving single-molecule detect

297 for mRNA stability and depicts a pathway of mRNA degradation with 5'- to 3'-polarity in cells devoid

298 een both RNA polymerase II transcription and mRNA degradation with growth rates in yeast.

299 ary role of the RNAi machinery is to promote mRNA degradation within the cytoplasm in a microRNA-depe

300 l cycle, and that the m(6)A reader promoting mRNA degradation, YTHDF2 (ref.