ライフサイエンスコーパス: mRNA stability

1 t transcript is a determinant of cytoplasmic mRNA stability.

2 tional level rather than an increased IL-1Ra mRNA stability.

3 ing possible roles in both transcription and mRNA stability.

4 itranscriptomic modification that determines mRNA stability.

5 t roles for Secisbp2 in UGA-redefinition and mRNA stability.

6 s that slower decoding is coupled to reduced mRNA stability.

7 f its RNA polymerases constant and increases mRNA stability.

8 tion-related diseases that involve increased mRNA stability.

9 tudied NOX4-mediated regulation of CCR2/CCL2 mRNA stability.

10 using significant dysregulation of host cell mRNA stability.

11 d the essentiality of a conserved 16-mer for mRNA stability.

12 ed the in vivo effect of sequence signals on mRNA stability.

13 by suppressing mRNA translation and reducing mRNA stability.

14 wly synthesized transcripts without inducing mRNA stability.

15 elongation rates are a major determinant of mRNA stability.

16 cytochrome b5 form A (CYB5A) to increase its mRNA stability.

17 RNA/pre-mRNA changes suggestive of increased mRNA stability.

18 sting that amino acid composition influences mRNA stability.

19 with no effect on its promoter activity and mRNA stability.

20 g the unfolded-protein response or affecting mRNA stability.

21 he level of editing initiation and/or edited mRNA stability.

22 interacts with and is regulated by PCBP4 via mRNA stability.

23 P domain is required for FASTKD3 function in mRNA stability.

24 FR2 stimulates Il2 promoter activity and Il2 mRNA stability.

25 y on those targets regulated at the level of mRNA stability.

26 v-FLIP mRNA, at least in part by increasing mRNA stability.

27 In addition, TTP reduced the NOX2 mRNA stability.

28 y is one feature that contributes greatly to mRNA stability.

29 ough combined increases in transcription and mRNA stability.

30 codon such that their inclusion can decrease mRNA stability.

31 otein previously implicated in regulation of mRNA stability.

32 slational efficiency and, surprisingly, also mRNA stability.

33 anner, and the Alu-derived 3' UTRs can alter mRNA stability.

34 ost-transcriptional mechanisms, particularly mRNA stability.

35 in the 3'-untranslated region to reduce ALK2 mRNA stability.

36 ctures at 3' ends are a major determinant of mRNA stability.

37 ng and tissue- and hormone response-specific mRNA stability.

38 , including transcription, RNA splicing, and mRNA stability.

39 g with target mRNAs, altering translation or mRNA stability.

40 cytoplasmic mRNA 3' polyA tails to regulate mRNA stability.

41 on studies, some mutations abrogated TBC1D24 mRNA stability.

42 suppressor of cytokine signaling-1 (SOCS-1) mRNA stability.

43 matopoiesis, and show that it regulates REST mRNA stability.

44 p53 protein, can regulate p21 expression via mRNA stability.

45 xidase 2 (Nox2) resulting from enhanced Nox2 mRNA stability.

46 egulate both CDKN2A-p16INK transcription and mRNA stability.

47 G16L1 translation, without affecting Atg16l1 mRNA stability.

48 ed MEF2C translation without affecting Mef2c mRNA stability.

49 within MIC-1 3'-UTR and then enhances MIC-1 mRNA stability.

50 promoted by the p97-UBXD8 complex to control mRNA stability.

51 ne (rny) led to a 2-fold increase in overall mRNA stability.

52 iption whereas HuR induction increased MAT2B mRNA stability.

53 e shown to affect not only splicing but also mRNA stability.

54 U2AF65 binds to such a site and controls the mRNA stability.

55 rted a novel regulation of MDM2 by RNPC1 via mRNA stability.

56 on by increasing IL-8 gene transcription and mRNA stability.

57 it surprisingly had little effects on their mRNA stability.

58 ulating pre-mRNA splicing, deadenylation and mRNA stability.

59 erefore reduced feedback from IL-10 on cox-2 mRNA stability.

60 and U2AF35 complexes supported their role in mRNA stability.

61 trol every step of RNA metabolism, including mRNA stability.

62 ovel regulation of MDM2 by the RBP RNPC1 via mRNA stability.

63 ich MIC-1 can be regulated through RNPC1 via mRNA stability.

64 gh its posttranscriptional regulation of TNF mRNA stability.

65 anscriptionally regulates HuR expression via mRNA stability.

66 uggesting that Dcp2 normally modulates IRF-7 mRNA stability.

67 ng the expression of cytokines by modulating mRNA stability.

68 nto the coupling of decoding efficiency with mRNA stability.

69 RNA secondary structure in the regulation of mRNA stability.

70 ch motifs that are associated with increased mRNA stability.

71 , suggesting that PARP1 might be involved in mRNA stability.

72 initiation increases protein expression and mRNA stability.

73 porA gene, indicating that T (porA) enhances mRNA stability.

74 a its tandem zinc finger motif to affect TOR mRNA stability.

75 -tail is not required for the codon-mediated mRNA stability.

76 ed with translational efficiency rather than mRNA stability.

77 ct of PHD3 depletion was pinpointed to HIF2A mRNA stability.

78 stem-loop on cagA transcript levels and cagA mRNA stability.

79 l mechanisms have been described that affect mRNA stability.

80 This event appears to be critical for edited mRNA stability.

81 tability, but instead to a decrease in Cxcl1 mRNA stability.

82 UTR harboring miRNA binding sites regulating mRNA stability.

83 related to an increase in TF messenger RNA (mRNA) stability.

84 ic regulation of both gene transcription and mRNA stabilities.

85 d and plays an essential role in controlling mRNA stability, a key step in the regulation of gene exp

86 esult of increased transcription and greater mRNA stability after LPS treatment.

87 ere that several factors affected glycolytic mRNA stability, among which were glucose sensing, protei

88 periment, RNA immunoprecipitation (RIP), and mRNA stability analysis, we evaluated the potential bind

89 enough attention is given to the question of mRNA stabilities and reliabilities of transcriptional da

90 lity in the brain, suggesting a link between mRNA stability and Alzheimer's disease."

91 mRNA, which correlated with increased FZD10 mRNA stability and an upregulation of the Wnt/beta-caten

92 tion N(6)-methyladenosine (m(6)A) influences mRNA stability and cell-type-specific developmental prog

93 the direct impact of PARP1 and PARylation on mRNA stability and decay.

94 We demonstrate that E2F1 mRNA stability and E2F1 protein levels are reduced in ce

95 mRNA cap methylation is essential for mRNA stability and efficient translation.

96 tions in transcriptional activity, splicing, mRNA stability and epigenetic modifications.

97 ioblastoma stem-like cells by modulating pre-mRNA stability and expression of the FOXM1 gene.

98 ilized AUF1 protein and thereby reduced tet1 mRNA stability and expression, which was able to demethy

99 rotein human antigen R (HuR), regulated XIAP mRNA stability and expression.

100 key post-transcriptional regulatory role in mRNA stability and functions in eukaryotes.

101 soforms had slightly but significantly lower mRNA stability and greater translational efficiency than

102 Hence, mTORC1 activity regulation of mRNA stability and high affinity HuD-target mRNA degrada

103 signaling in primary human T cells decreased mRNA stability and inhibited secretion of IL-2, IL-4, an

104 tif protein, RBM24, positively controls Sox2 mRNA stability and is necessary for optimal SOX2 mRNA an

105 have identified factors that regulate Gap-43 mRNA stability and localization, but it remains unclear

106 mRNA 3'-UTR length, resulting in changes in mRNA stability and localization.

107 mRNA stability and luciferase assays demonstrated APA-de

108 ndrion-targeted PPR78 protein in nad5 mature mRNA stability and maize (Zea mays) seed development.

109 global effects, such as translation rate on mRNA stability and mRNA secondary structure on translati

110 changes were caused by regulation of tubulin mRNA stability and not transcription.

111 Here, we describe regulation of mRNA stability and P-body dynamics by the inositol pyrop

112 gest that PCBP2 regulates p73 expression via mRNA stability and p73-dependent biological function in

113 mRNA stability and polysome studies suggest IGF2BP1 medi

114 s interaction, HuR selectively increased CRP mRNA stability and promoted CRP translation.

115 cultures and model organisms, this decreases mRNA stability and protein expression.

116 ects on mRNA that were coupled to effects on mRNA stability and protein production.

117 human genes on steady-state mRNA abundance, mRNA stability and protein production.

118 ns and ER stress, leads to the regulation of mRNA stability and protein synthesis through posttranscr

119 apparently critical element of mitochondrial mRNA stability and quality control.

120 is important for transcription termination, mRNA stability and regulation of gene expression.

121 Translation efficiency can be affected by mRNA stability and secondary structures, including G-qua

122 Furthermore, we found differential Shank3 mRNA stability and SHANK1/2 upregulation in these two li

123 n-small cell lung cancer cells with enhanced mRNA stability and subsequent elevated expression of p21

124 show that local translation is regulated by mRNA stability and that NMD acts locally to influence ax

125 precursor is essential for the regulation of mRNA stability and the initiation of translation.

126 accurate stop-start transcription as well as mRNA stability and translation and, therefore, for virus

127 t modulate global and/or transcript-specific mRNA stability and translation contribute to the rapid a

128 onserved "codon optimality code" that shapes mRNA stability and translation efficiency across vertebr

129 These 5'-UTR sequences confer distinct mRNA stability and translation efficiency to the Prrxl1

130 rily conserved regulatory RNAs that modulate mRNA stability and translation in a wide range of cell t

131 he RNA interference (RNAi) pathway regulates mRNA stability and translation in nearly all human cells

132 ates alternative splicing in the nucleus and mRNA stability and translation in the cytoplasm.

133 a pro-inflammatory and cancer marker, whose mRNA stability and translation is regulated by the CUG-b

134 hat undefined trans-acting factors governing mRNA stability and translation may also contribute to xC

135 MicroRNAs (miRNAs) regulate mRNA stability and translation through the action of the

136 on levels of multiple proteins by decreasing mRNA stability and translation, and could therefore be k

137 mRNA poly(A) tails are important for mRNA stability and translation, and enzymes that regulat

138 Cytoplasmic Rbfox1 binding increased target mRNA stability and translation, and Rbfox1 and miRNA bin

139 MicroRNAs are well known regulators of mRNA stability and translation.

140 methyladenosine (m6A) modification regulates mRNA stability and translation.

141 sRNAs) and the RNA chaperone Hfq to regulate mRNA stability and translation.

142 l target to regulate inflammatory cytokines' mRNA stability and translation.

143 bfox proteins regulate alternative splicing, mRNA stability and translation.

144 ons, while in the cytoplasm, CELF1 regulates mRNA stability and translation.

145 es mRNA poly(A) tails to regulate eukaryotic mRNA stability and translation.

146 asis and responses through the regulation of mRNA stability and translation.

147 TRs) regulate gene expression by controlling mRNA stability and translation.

148 The regulation of TNLs via UPF1/NMD-mediated mRNA stability and translational derepression offers a d

149 Although it was once thought that mRNA stability and translational efficiency were directl

150 dent mechanisms determine GRN expression via mRNA stability and translational efficiency.

151 A:mRNA base-pairing often results in altered mRNA stability and/or altered translation initiation.

152 ), a factor involved in splicing regulation, mRNA stability, and mRNA transport.

153 d negative (pilus operon mRNA) regulation of mRNA stability, and negative regulation of mRNA translat

154 cluding epigenetic control of transcription, mRNA stability, and protein localization.

155 ated in processes such as vesicle formation, mRNA stability, and protein ubiquitination and trafficki

156 gulatory RNAs may positively regulate target mRNA stability, and to how CRISPR RNAs are processed fro

157 the relative contribution of transcription, mRNA stability, and translation efficiency on cytokine p

158 e expression through modulation of splicing, mRNA stability, and translation.

159 Pre-mRNA splicing and mRNA stability are fundamentally altered under some stre

160 Modulators of mRNA stability are not well understood in melanoma, an a

161 ecies-specific factors influence post-mortem mRNA stability are poorly understood.

162 se connections between protein synthesis and mRNA stability are widespread or whether other modes of

163 Using tubulin mRNA stability as a signature to query the Gene Expressi

164 l role of FMRP in codon optimality-dependent mRNA stability as an important factor in FXS.

165 ty that YlbF, YmcA and YaaT broadly regulate mRNA stability as part of an RNase Y-containing, multi-s

166 ssays identified IGF2BP3, an RBP involved in mRNA stability, as a binding partner for linc-SPRY3-2/3/

167 that targeting these three 3'-UTRs increased mRNA stability, as predicted by the reporter assay, whil

168 enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an

169 electron microscopy, ribosome profiling, and mRNA stability assays to examine the recruitment of Ccr4

170 not TLR7-mediated costimulation, can enhance mRNA stability at low Ag levels.

171 rogeneous Imp expression correlates with myc mRNA stability between individual neuroblasts in the bra

172 stimulates NRT1.1 transcription and probably mRNA stability both in primary root tissues and in LRPs,

173 y is a conserved mechanism to shape maternal mRNA stability by affecting deadenylation rate in a tran

174 Our results suggest that Snf1 may influence mRNA stability by altering the recruitment activity of t

175 We conclude that tight control of IL23 mRNA stability by TTP is critical to avoid severe inflam

176 to play a critical role in the regulation of mRNA stability, cellular localization and translation ef

177 We conclude that the increased speB mRNA stability contributes to the rapid accumulation of

178 D-treated cells utilized transcriptional and mRNA stability control mechanisms which were likely majo

179 with DGCR8/Drosha and DGCR8/Drosha-regulated mRNA stability control, suggesting unique RNA regulation

180 demonstrate that the temporal regulation of mRNA stability coordinates vital cellular pathways and i

181 Following LPS stimulation, this increased mRNA stability correlated to an elevated induction of bo

182 ssion can be achieved through the control of mRNA stability, cytoplasmic compartmentalization, 3' UTR

183 egulate AU-rich elements containing cytokine mRNA stability/degradation and translation.

184 r, translation has also been shown to affect mRNA stability depending on codon composition in model o

185 n to hypoxic stress and that HIF1A and HIF2A mRNA stability differences contribute to HIF switch.

186 ed how codon identity and translation affect mRNA stability during development and homeostasis.

187 ESA to identify sequence elements modulating mRNA stability during zebrafish embryogenesis.

188 hylated cap structure, which is required for mRNA stability, efficient translation, and evasion of an

189 ic ductal adenocarcinomas (PDAC) rely on the mRNA stability factor HuR (ELAV-L1) to drive cancer grow

190 t due to its dependence on the pro-oncogenic mRNA stability factor HuR (ELAVL1).

191 on mediate a regulatory interaction with the mRNA stability factor HuR (Hu antigen R) in the context

192 line was used to isolate mutants of the petA mRNA stability factor MCA1 and the translation factor TC

193 propose that Imp-dependent regulation of myc mRNA stability fine-tunes individual neural stem cell pr

194 s have directly and comprehensively analyzed mRNA stability following death, and in particular the ex

195 NA levels alter, suggesting Puf3p determines mRNA stability for only a limited subset of its target m

196 tly, motif quality is a major determinant of mRNA stability for Puf3 targets in vivo and can be used

197 duction was characterized by remarkably high mRNA stability for this cytokine.

198 lated their mRNA concentration by uncoupling mRNA stability from the transcription rate.

199 While mRNA stability has been demonstrated to control rates of

200 e evidence that translation strongly affects mRNA stability in a codon-dependent manner in human cell

201 gnaling modulates translation efficiency and mRNA stability in a transcript-specific manner.

202 earch for post-transcriptional modulators of mRNA stability in breast cancer by conducting whole-geno

203 -27b caused reciprocal alterations in CX3CL1 mRNA stability in liver epithelial cells.

204 view is an update to our 2001 Gene review on mRNA stability in mammalian cells, and we survey the eno

205 s a broad range of translational outputs and mRNA stability in mammalian cells.

206 determinant of translational efficiency and mRNA stability in model organisms and human cell lines.

207 se with deadenylation activity that controls mRNA stability in part and therefore regulates expressio

208 and Hog1 controlling ribosome biogenesis via mRNA stability in response to glucose availability in th

209 We evaluated the prevalence of changes in mRNA stability in response to sodium arsenite in human f

210 r RNAs can be used as a surrogate marker for mRNA stability in the absence of transcription.

211 ntial mRNA decay from RNA-seq data and model mRNA stability in the brain, suggesting a link between m

212 for nonsense-mediated decay (NMD) regulating mRNA stability in the cytoplasm.

213 achine learning model that predicts reporter mRNA stability in vivo.

214 We show that mRNA stability, in addition to transcription, is key in

215 m(6)A predominantly and directly reduces mRNA stability, including that of key naive pluripotency

216 Our work suggests that sinR mRNA stability is an additional posttranscriptional cont

217 Control over mRNA stability is an essential part of gene regulation t

218 te that the regulatory information affecting mRNA stability is encoded in codons and not in nucleotid

219 Our data indicate that E47 and AID mRNA stability is lower in stimulated B cells from elder

220 scription is unaffected in sld mice, whereas mRNA stability is markedly decreased.

221 Decreased mRNA stability is not due to a defect in 3'-end processi

222 Instead, IL-4 mRNA stability is reduced in IRE1alpha KO T cells.

223 We conclude that arsenite modification of mRNA stability is relatively uncommon, but in some insta

224 ether other modes of regulation dominate the mRNA stability landscape in higher organisms.

225 roteins and four microRNAs that modulate the mRNA stability landscape of the brain, which suggests a

226 ession in part by specifically enhancing its mRNA stability, leading to cell proliferation and tumori

227 s system, many pathways are regulated at the mRNA stability level.

228 on is extensively regulated at the levels of mRNA stability, localization and translation.

229 coordination between splicing regulation and mRNA stability may provide a novel paradigm to control s

230 Mechanistically, results obtained using mRNA stability measurements as well as intronic RNA expr

231 effect on protein expression independent of mRNA stability mechanisms.

232 se Y is a pleiotropic regulator required for mRNA stability, mRNA processing, and removal of read-thr

233 To examine the role of splicing factors in mRNA stability, mutations were introduced into the polyp

234 ions as a tumor suppressor by regulating the mRNA stability of a number of mRNAs involved in hypoxia

235 This effect is due to decreased mRNA stability of both targets.

236 ated knockdown of NRP1 reduced the level and mRNA stability of DDAH1 but not DDAH2 in HUVECs, whereas

237 whereas overexpression of NRP1 increased the mRNA stability of DDAH1.

238 m involving polyamine influx which modulates mRNA stability of heat-inducible genes under heat stress

239 ibited the AIM2 inflammasome by reducing the mRNA stability of IFN regulatory factor 7, which regulat

240 protein tristetraprolin (TTP) in influencing mRNA stability of IL12p35, IL12/23p40, and IL23p19 subun

241 as an RNA binding protein that regulates the mRNA stability of NBS1, BRCA1, and other DNA damage-rela

242 nhibited the Lcn2 promoter by regulating the mRNA stability of Nfkbiz, encoding the IkappaBzeta trans

243 Moreover, ALKBH5 affects mRNA stability of receptor tyrosine kinase AXL in an m(6

244 polymorphisms also differentially affect the mRNA stability of SAUR26 at two temperatures.

245 They control the mRNA stability of several inflammatory cytokines, includ

246 R they would be able to selectively regulate mRNA stability of specific genes such as c-Myc.

247 in that regulates translation initiation and mRNA stability of target transcripts.

248 inding sites supporting a regulatory role in mRNA stability of these transcripts.

249 y reducing m(6)A levels at the 3'UTR and the mRNA stability of two phosphodiesterase genes (PDE1C and

250 arrangements had no apparent effects on flgM mRNA stability or predicted mRNA secondary structures.

251 paB and IFN regulatory factors, nor for Ccl5 mRNA stability or splicing.

252 nduced genes lowered mRNA levels by reducing mRNA stability or the transcription rate, respectively.

253 mRNA stability or translatability can be regulated by th

254 tion of all small RNAs (sRNAs) that regulate mRNA stability or translation by limited base pairing in

255 se correlation between m(6)A methylation and mRNA stability or translational efficiency.

256 eliminated changes in globin messenger RNA (mRNA) stability or cellular location and reduction of ad

257 t effects on transcription, mRNA processing, mRNA stability, or protein stability.

258 ucture of mRNA via changes in transcription, mRNA stability, or splicing, and very few cases involve

259 Through a mechanism involving increased mRNA stability (p = 0.007), ataluren treatment of HEK-29

260 of P-body localization, mRNA translation and mRNA stability: P-bodies contain mostly AU-rich mRNAs, w

261 many potential outcomes, including changing mRNA stability, protein recruitment, and translation.

262 ditional functions of capping are to promote mRNA stability, protein translation, and concealment fro

263 is maintained by a feed-forward loop between mRNA stability regulated by PABPN1 and protein turnover

264 usion model with a source simulated to model mRNA stability regulation, our results establish that th

265 properties and identify TGF-beta as a novel mRNA stability regulator in intestinal epithelium throug

266 The RBP LARP1 is an mRNA stability regulator, and elevated expression of the

267 nd trans-factors are integrated to determine mRNA stability remains poorly understood.

268 e describe an increase in TNF-alpha message, mRNA stability, soluble protein release, and membrane ex

269 tide modification in mRNA, known to regulate mRNA stability, splicing, and translation, but it is unc

270 In vivo mRNA stability studies revealed the newly created termin

271 ntial for many biological activities such as mRNA stability, sub-cellular localization, protein trans

272 ted strongly with total mRNA expression, not mRNA stability, suggesting transcriptional rather than p

273 he long RPB2 mRNA is not caused by increased mRNA stability, supporting the preferential usage of the

274 two factors competing for influence on stim1 mRNA stability: the mRNA-stabilizing protein HuR and the

275 coholic liver injury and regulates CCR2/CCL2 mRNA stability thereby promoting recruitment of inflamma

276 x maintains the balance between splicing and mRNA stability through methylation of ZNF326.

277 PARN regulates TP53 mRNA stability through not only an ARE but also an adjac

278 impact of TTP on IL23 production and IL23p19 mRNA stability through several AREs in the 3' untranslat

279 on, whereas Bank1(-/-) had no effect on IL-6 mRNA stability, thus suggesting that BANK1 has no effect

280 In parallel the 5' UTR also affects mRNA stability; thus two independent mechanisms determin

281 4 regulation while those at the 3'UTR affect mRNA stability to generate variations in SAUR26 expressi

282 Imp levels throughout development limit myc mRNA stability to restrain neuroblast growth and divisio

283 ndamental aspects of mRNA metabolism, mainly mRNA stability, to determine stem cell fates.

284 sses through its effects on gene expression, mRNA stability, translatability, and transport.

285 protein content, whereas FUS does not affect mRNA stability/translation of its targets.

286 regulator of myogenesis, while leaving MYOD mRNA stability unaffected.

287 ion site, and defined the role the 3'-UTR in mRNA stability using a luciferase reporter assay.

288 se (PI3K) activity, indeed regulates tubulin mRNA stability via changes in microtubule dynamics.

289 ugh a mechanism involving increases in PD-L1 mRNA stability via modulation of the AU-rich element-bin

290 also showed that PCBP2 is necessary for p73 mRNA stability via the CU-rich elements in p73 3'-UTR.

291 Moreover, we show that pseudogenes regulate mRNA stability via the piRNA pathway.

292 s and nuclear processing of the mRNA, though mRNA stability was not affected.

293 n RNA-binding protein (RBP) known to enhance mRNA stability, was involved in T cell activation-depend

294 olved in translational control as well as in mRNA stability, we compared the expression of GRN in cel

295 However, TTP's effects on AU-rich mRNA stability were negligible and limited by constituti

296 shortening leads to transcripts with higher mRNA stability, which augments transcriptional activatio

297 P1, mediates the autogenous control of 5'TOP mRNA stability, whose disruption is implicated in the pa

298 y can be estimated alongside individual gene mRNA stability with the help of a Bayesian reversible ju

299 eded for maintaining Me31B protein level and mRNA stability, with Tral's effect being more specific.

300 sion of iNOS, IL-8 and TNF-alpha by reducing mRNA stability without inhibition of the promoter activi