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1 ion of the EIF3F gene, while promoting eIF3f mRNA translation.
2 ency with PRC2 overexpression via control of mRNA translation.
3 family of oncogenes are master regulators of mRNA translation.
4 tes, nor whether it can selectively regulate mRNA translation.
5 that internal m(7)G methylation could affect mRNA translation.
6 NA in the cytoplasm and negatively regulates mRNA translation.
7 e effects of prolonged IFNgamma treatment on mRNA translation.
8 tein PABPC1 for activation of Musashi target mRNA translation.
9 ding RNAs, a number of which are involved in mRNA translation.
10 led changes in poly(A) tail length influence mRNA translation.
11 HFV nucleocapsid protein (CCHFV-NP) augments mRNA translation.
12 ntial for maturation of functional tRNAs and mRNA translation.
13 s and relieves its inhibitory activity on RP mRNA translation.
14 y stage, ranging from chromatin packaging to mRNA translation.
15 ally involved in ribosomal RNA synthesis and mRNA translation.
16 inding that RNA hydroxymethylation can favor mRNA translation.
17 through reprogramming gene transcription and mRNA translation.
18 y induces an anti-viral response by limiting mRNA translation.
19 p53 activation and a resultant inhibition of mRNA translation.
20 2 from a repressor to an activator of target mRNA translation.
21 l protein O-GlcNAcylation and increased Cd40 mRNA translation.
22 hosphorylation of eIF2alpha, an inhibitor of mRNA translation.
23 vation of ERK and mTOR signaling upstream of mRNA translation.
24 a transient adaptive reprogramming of global mRNA translation.
25 P2), rendering it unable to repress ferritin mRNA translation.
26 ss116 with Pet309 but also do not allow COX1 mRNA translation.
27 nts (ribosome profiling) maps and quantifies mRNA translation.
28 rated by alternative splicing promote axonal mRNA translation.
29 nuanced ligand response observed during bulk mRNA translation.
30 ress responses and an important regulator of mRNA translation.
31 rough the modulation of apolipoproteinB/Apob mRNA translation.
32 ledge gap is the role of nuclear proteins in mRNA translation.
33 found that RNA hydroxymethylation can favor mRNA translation.
34 ancreatic cancer proliferation by regulating mRNA translation.
35 cellular processes, including cap-dependent mRNA translation.
36 or suppressor of 5'-terminal oligopyrimidine mRNA translation.
37 all, noncoding RNA that negatively regulates mRNA translation.
38 s with hnRNP-Q1 as a means to inhibit Gap-43 mRNA translation.
39 tely elevating Ccnd1 transcription and Ccnd1 mRNA translation.
40 n, Torin1, and amino acid deprivation on TOP mRNA translation.
41 messenger RNA (mRNA) degradation and repress mRNA translation.
42 tory events such as alternative splicing and mRNA translation.
43 several aspects of RNA regulation, including mRNA translation.
44 synthesis, including ribosome biogenesis and mRNA translation.
45 nscription initiation, mRNA degradation, and mRNA translation.
46 recent advances in mathematical modelling of mRNA translation.
47 positively or negatively with cognate sense mRNA translation.
48 h from a repressor to an activator of target mRNA translation.
49 ry few cases involve the regulation of sense mRNA translation.
50 iptional output with selective modulation of mRNA translation.
51 tions of tRNA fragments in the regulation of mRNA translation, a critical component of cellular stres
52 rting the role of ABCF1 in m(6)A-facilitated mRNA translation, ABCF1-sensitive transcripts largely ov
54 n-17a-dependent manner, which reduced global mRNA translation and altered nascent proteome synthesis.
56 of p21 in Ola1(-/-) MEFs is due to enhanced mRNA translation and can be prevented by either reconsti
59 strategy used by viruses to repress cellular mRNA translation and concomitantly allow the efficient t
60 characterized by persistently elevated uORF mRNA translation and concurrent gene expression reprogra
63 he mRNA 5'-cap are useful tools for studying mRNA translation and degradation, with emerging potentia
64 ic WNT3 further regulates the specificity of mRNA translation and development of neurons and oligoden
65 ase activity links development with maternal mRNA translation and ensures irreversibility of the oocy
66 g protein 1 (JAKMIP1) in regulating neuronal mRNA translation and establish JAKMIP1 knockout mice as
67 t mice did not exhibit enhanced retinal Cd40 mRNA translation and failed to up-regulate expression of
69 des an important resource for studying local mRNA translation and has the potential to reveal both co
70 play an important role in the regulation of mRNA translation and have therapeutic potential in cance
71 which cells sense and restore dysfunctional mRNA translation and how this is linked to cell prolifer
73 of PPR proteins and the mechanisms governing mRNA translation and intron splicing in plant mitochondr
74 negatively regulates the elongation stage of mRNA translation and is activated under different stress
76 mRNA fate, in terms of P-body localization, mRNA translation and mRNA stability: P-bodies contain mo
77 G4DNA in the cytoplasm are known to modulate mRNA translation and participate in stress granule forma
78 (mTORC1) has an essential role in dendritic mRNA translation and participates in mechanisms underlyi
79 displayed antiviral activity: inhibitors of mRNA translation and predicted regulators of the sigma-1
81 caused alterations in proteins required for mRNA translation and protein secretion, reduced producti
83 of cis-NATs known to regulate cognate sense mRNA translation and provide a foundation for future stu
84 , which invert the programmed local speed of mRNA translation and provide direct evidence for the cen
86 these uS12 variants impaired the accuracy of mRNA translation and rendered cells highly sensitive to
87 transcriptional program leading to enhanced mRNA translation and resulting in an increased PD-1 amou
89 nit alpha (eIF2alpha), causing inhibition of mRNA translation and shutdown of viral protein productio
90 ve molecular switch for turning off or on RP mRNA translation and subsequent ribosome biogenesis.
91 isoforms through APA in coding sequence and mRNA translation and that the p63-PABPN1 loop modulates
92 ote carcinogenesis by effects on both global mRNA translation and upregulated expression of specific
93 tomic modifications, can positively regulate mRNA translation and/or stability, and both DNA and RNA
95 3 (eIF3) acts as a distinct repressor of FTL mRNA translation, and eIF3-mediated FTL repression is di
96 the stage for discussion on mTOR signaling, mRNA translation, and metabolic adaptation in T cells.
97 d by the balance between gene transcription, mRNA translation, and protein degradation, among other f
99 recognized role of Pdcd4 in controlling BDNF mRNA translation, and provided a new method that boostin
100 atypical brain amino acid profile, abnormal mRNA translation, and severe neurological abnormalities.
101 NP L, synergizes with miR-297, reduces VEGFA mRNA translation, and triggers apoptosis, thereby suppre
102 rimentally defined, we systematically probed mRNA, translation, and protein signatures that were eith
103 T The elongation and/or termination steps of mRNA translation are emerging as important control point
104 global protein synthesis and increased uORF mRNA translation are followed by normalization of protei
105 n transcriptional factors, genes involved in mRNA translation are highly represented in our interacto
107 protein 1) and enhanced cap-independent Cd40 mRNA translation as assessed by a bicistronic reporter t
108 omains of DNA-based life, where they mediate mRNA translation as part of polyribosomes in animals.
109 l cues by regulating ribosome biogenesis and mRNA translation at multiple levels to sustain prolifera
110 in 2 (CYFIP2) has been suggested to regulate mRNA translation at synapses and this may include local
115 essing) inhibitory neurons increased general mRNA translation, bolstered synaptic plasticity and enha
116 striking upregulation of pathways linked to mRNA translation both in CLL cells derived from lymph no
117 epleting PCIF1 does not substantially affect mRNA translation but is associated with reduced stabilit
118 Evidence also exists for clock control of mRNA translation, but the extent and mechanisms for this
119 (N) with this conserved sequence facilitates mRNA translation by a unique N-mediated translation stra
121 tion of the protein, but rather to decreased mRNA translation by nonsense-mediated decay regulation o
123 Post-transcriptional regulation of COX-2 mRNAs translation by SGs indicates a role in IL-1beta-me
124 n-independent and that mechanisms regulating mRNA translation, cell cycle progression, and gene expre
125 out eukaryotic evolution and plays a role in mRNA translation, cellular proliferation, cellular diffe
126 analysis reveals a global switch in maternal mRNA translation coinciding with oocyte re-entry into th
127 ediating mGluR-LTD through the regulation of mRNA translation complexes stalled at the level of elong
128 scent peptide-mediated anchoring of ribosome-mRNA translation complexes to the inclusions is suggeste
131 sed Ccnb1 and Moloney sarcoma oncogene (Mos) mRNA translation, delayed spindle assembly and increased
132 c molecular pathway lies alongside the known mRNA translation-dependent processes necessary for long-
136 ere we performed genome-wide measurements of mRNA translation during histidine starvation in fission
138 is regulated at the level of messenger RNA (mRNA) translation during human hematopoietic development
139 HA-tagged histones in U2OS cells and single mRNA translation dynamics in both U2OS cells and neurons
141 ulate protein expression levels by affecting mRNA translation efficiency, but the underlying mechanis
143 usage plays an important role in regulating mRNA translation efficiency. We found that the rare codo
144 he retina of diabetic mice, the repressor of mRNA translation, eIF4E-binding protein 1 (4E-BP1), is O
146 to catalyze the hypusine modification of the mRNA translation factor eIF5A and promotes oncogenesis t
147 showed AD-associated hyperphosphorylation of mRNA translation factor eukaryotic elongation factor 2 (
149 nscription factors, regulators of chromatin, mRNA translation, GTPases, vesicle trafficking, and the
150 convallatoxin as a novel antiviral, limiting mRNA translation has a dramatic impact on CMV infection
151 The finding that Rbfox proteins regulate mRNA translation has implications for Rbfox-related dise
152 itochondrial outer membrane (MOM)-associated mRNA translation, how this process is sensitive to mitoc
153 by anchor the complex for multiple rounds of mRNA translation.IMPORTANCE Poxvirus genome replication,
155 thways that regulate protein homeostasis and mRNA translation in a manner that was both rapamycin-sen
157 his rapid growth generates a high demand for mRNA translation in a timing-dependent manner, but its u
160 earch for cis-NATs influencing cognate sense mRNA translation in Arabidopsis (Arabidopsis thaliana).
163 genesis, but the mechanisms that modulate RP-mRNA translation in coordination with other cellular pro
166 gnaling and the spatiotemporal regulation of mRNA translation in highly complex developing systems.
167 intricate regulation of compartment-specific mRNA translation in mammalian CNS axons supports the for
168 Here we demonstrate that the timing of Ccnb1 mRNA translation in mouse oocytes is dependent on the pr
174 q approach to explore the timing of maternal mRNA translation in quiescent oocytes as well as in oocy
175 female mice to comprehensively characterize mRNA translation in Scn10a-positive nociceptors in chemo
176 to comprehensively characterize and compare mRNA translation in Scn10a-positive nociceptors in the T
178 ntal role of mRNA localization and dendritic mRNA translation in synaptic maintenance and plasticity
179 its secretion is dependent on activation of mRNA translation in synchrony with the cell cycle and th
180 own as a mechanism for controlling mammalian mRNA translation in the cytoplasm, but what would be the
181 n of 4E-BP1/2 prevented the increase in Cd40 mRNA translation in TMG-exposed cells, and expression of
182 embly and ribosome profiling to study global mRNA translation in tomato (Solanum lycopersicum) roots.
183 ow that GADD34 drives substantial changes in mRNA translation in unstressed cells, particularly targe
184 Overexpression of W73V suppressed reporter mRNA translation in vitro and in vivo and reduced the le
185 on is functionally coupled to messenger RNA (mRNA) translation in bacteria, but how this is achieved
186 ), ribonucleoprotein complexes that regulate mRNA translation, in the delayed translation of COX-2 mR
190 plex 1 (mTORC1) that represses cap-dependent mRNA translation initiation by sequestering the translat
191 educed activity of mTORC1 and its downstream mRNA translation initiation factors eIF4B and 4EBP1, as
192 nternal ribosome entry site (IRES)-dependent mRNA translation initiation pathway results in continued
193 ive ribosome profiling to gain insights into mRNA translation initiation, highlighting distinctions b
194 e protein synthesis is largely controlled by mRNA translation initiation, whether cellular translatio
200 us, DMD is required to safeguard ER-targeted mRNA translation, intracellular calcium homeostasis, and
205 ore transcriptional competency when maternal mRNA translation is blocked, whereas inhibition of histo
208 out neurons, type 1 adenylyl cyclase (Adcy1) mRNA translation is enhanced, leading to excessive produ
211 y initiation is repressed, and cap-dependent mRNA translation is maintained during mitosis despite mT
221 tionships between immunity, endocytosis, and mRNA translation lead to hypothesize that toll-like rece
222 possesses RNA topoisomerase activity, binds mRNA translation machinery and interacts with an RNA-bin
225 nifested as alterations in the efficiency of mRNA translation modulating protein levels in the absenc
226 Quantitative and qualitative changes in mRNA translation occur in tumor cells and support cancer
230 a focused RNAi approach that Nup155 controls mRNA translation of p21 (CDKN1A), a key mediator of the
231 Herein, we show that Aven stimulates the mRNA translation of the mixed lineage leukemia (MLL) pro
232 factor 4F complex (eIF4F) and initiation of mRNA translation of type II interferon-stimulated genes.
233 eaking down the targeted transcript, inhibit mRNA translation or alter the maturation of the pre-mRNA
234 -I editing are varied and include effects on mRNA translation, pre-mRNA splicing, and micro-RNA silen
235 not change global translation or individual mRNA translation profiles as measured by single-cell nas
236 reporter assay, we investigated how rates of mRNA translation, protein synthesis and degradation cont
237 efore hnRNP-Q1-mediated repression of Gap-43 mRNA translation provides an additional mechanism for re
238 well-documented attenuation of cap-dependent mRNA translation, rapamycin can augment NMD of certain t
240 normalizes stimulus-induced and constitutive mRNA translation rate, decreases lactate and key glycoly
241 urse analysis to measure the mRNA-abundance, mRNA-translation rate and protein expression during the
245 ryo transition involves extensive changes in mRNA translation, regulated in Drosophila by the PNG kin
247 ished roles as an inhibitor of cap-dependent mRNA translation, relatively little is known about its e
248 t is therefore important that the process of mRNA translation remains in excellent synchrony with cel
252 bations in cellular pathways associated with mRNA translation, ribosome biogenesis and stress signali
253 binding to the CARE and stimulation of VEGFA mRNA translation, simultaneously permitting miR-297-medi
254 ects post-transcriptional gene regulation in mRNA translation, stability, and localization, and exhib
257 F277 recognizes nascent uS5 in the course of mRNA translation, suggesting cotranslational assembly of
258 bitors undergoes a reversible remodelling of mRNA translation that evolves in parallel with drug sens
259 hat N(6)-methyladenosine (m(6)A) facilitates mRNA translation that is resistant to eIF4F inactivation
261 the scope and mechanism of eIF4F-independent mRNA translation, these findings reshape our current per
263 te no evidence of a reduction in the rate of mRNA translation, these uS12 variants impaired the accur
265 processes is the repression of initiation of mRNA translation through GCN2 phosphorylation of eIF2alp
268 forming CTORC2, and controls messenger RNA (mRNA) translation through phosphorylation of LARP1 and r
269 city switches from injury-associated protein mRNA translation to CK2alpha translation with endoplasmi
270 for DHPS in beta cells to link polyamines to mRNA translation to effect facultative cellular prolifer
271 the neuronal soma and make use of localized mRNA translation to rapidly respond to different extrace
272 ereas zinc-finger disruption decreases viral mRNA translation, tubule formation and virus replication
277 ate that Rictor is regulated at the level of mRNA translation via heat-shock transcription factor 1 (
278 icularly through cap-dependent initiation of mRNA translation via the phosphorylation and inactivatio
279 We demonstrate that GLD-1 represses ced-3 mRNA translation via two binding sites in its 3' untrans
281 oplasts, the impact of cis-NAT expression on mRNA translation was confirmed for 4 out of 5 tested cis
282 tection of MTOR-dependent changes in non-TOP mRNA translation was obscured by low sensitivity and met
284 tress granule protein G3BP1, known to arrest mRNA translation, was identified as a regulator of RIG-I
285 s the effects of phosphorylated eIF2alpha on mRNA translation, was sufficient to reverse the social d
286 Similar effects on O-GlcNAcylation and Cd40 mRNA translation were also observed in the retina of a m
287 During cell culture, changes in recombinant mRNA translation were consistent with changes in transcr
288 Inhibition of SGs clearance blocked COX-2 mRNA translation whereas blocking the assembly of SGs by
289 ciate with polyribosomes, which are units of mRNA translation, whereas the Top3 homologs from E. coli
290 hat the NS1 non-tubular form upregulates BTV mRNA translation, whereas zinc-finger disruption decreas
291 ulated by distinct oncogenes at the level of mRNA translation, which can be exploited for new immunot
292 ng as a negative regulator of p21(Waf1/Cip1) mRNA translation, which promotes exit of the Bmi1-Cre(ER
293 f BCR stimulation to increase messenger RNA (mRNA) translation, which can promote carcinogenesis by e
294 HAdVs) shut down host cellular cap-dependent mRNA translation while initiating the translation of vir
295 bited both cap-dependent and cap-independent mRNA translation while maintaining mRNA polysomal associ
296 led clear trends toward global reductions in mRNA translation with a significant reduction in the pol
297 Therefore, LNP uptake, endosomal escape, and mRNA translation with and without TLR4 activation are qu
298 lts in PI3Kdelta-dependent induction of E2F1 mRNA translation with the consequent activation of c-Myc
299 d rates of cell population growth and global mRNA translation, with peak rates occurring at normal ph
300 that FASTKD3 is required for efficient COX1 mRNA translation without altering mRNA levels, which res