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1 mRNA expression of PAX9, MSX1, AXIN2, and RUNX2 (known t
2 mRNA levels are determined by the balance between mRNA s
3 mRNA translation represents the last step of genetic flo
7 ld increase in primiR-199a1 and primiR-199a2 mRNA levels in mouse islets cultured in 10 mm glucose co
9 ll as increased VEGFR1 and interleukin-1beta mRNA expression in females, and reduced brain derived ne
13 ophyllide a oxygenase (CAO) gene having a 5' mRNA extension encoding a Nab1 translational repressor b
15 e transcriptome and observed that it affects mRNA levels of hundreds of genes that are significantly
18 on when cultured on bone slices, and altered mRNA expression of related chemokine receptors and ligan
21 Therefore, LNP uptake, endosomal escape, and mRNA translation with and without TLR4 activation are qu
22 t on mitochondrial respiration/function, and mRNA export occurs in the absence of Fzo1, which is requ
23 showed long-range chromatin interactions and mRNA abundance associations with target genes, and were
24 of cell-free RNAs, efficient cell lysis and mRNA capture, achieving highest mRNA detection accuracy
25 nclusions: This study of sputum microRNA and mRNA expression from patients with asthma demonstrates t
27 electron microscopy, ribosome profiling, and mRNA stability assays to examine the recruitment of Ccr4
28 yed higher discrepancies between protein and mRNA expression in paired primary/metastatic melanoma or
29 wed that in epimastigotes, TcHTE protein and mRNA levels decrease in response to increments in heme c
31 y and reduced levels of occludin protein and mRNA without affecting the expression of other transmemb
34 periment, RNA immunoprecipitation (RIP), and mRNA stability analysis, we evaluated the potential bind
35 analysis of transcriptome-wide m(6)A-seq and mRNA-seq analysis identified the glutamine transporter S
36 bserved, including alternative splicing, and mRNA expression levels of proto-oncogenes and tumor supp
43 intracellular Ca(2+) uptake and Na, K-ATPase mRNA were determined in the cultured epithelial cells fr
45 recognized role of Pdcd4 in controlling BDNF mRNA translation, and provided a new method that boostin
47 aine-homocysteine S-methyltransferase (Bhmt) mRNA and protein levels following repeated treatments we
51 mediated mRNA decay (NMD) degrades EJC-bound mRNA, but the lack of suitable methodology has prevented
52 le in the adult mouse heart at baseline, but mRNA and protein are induced after ischemia-reperfusion
53 nthesis and were differentially regulated by mRNA decay pathways, raising the possibility that one di
54 ensor that is activated to splice the bZIP60 mRNA that produces a truncated transcription factor that
57 ism was higher in embryos injected with Cas9 mRNA (100%) compared to those injected with Cas9 protein
59 g growth factor pharmacotherapy show that cf-mRNA reflects dynamic functional changes over time assoc
60 ty purification and qPCR was used to compare mRNA expression of nrg1,2,3,4 and erbB1,2,3,4 in PV and
62 y and cis-regulatory elements uncover a core mRNA-ncRNA transcriptional signature shared by IgG(+) an
66 nerally, this suggests an LNP which delivers mRNA to one inflammatory disease may not deliver mRNA to
67 eshift-inducing stem-loops from E. coli dnaX mRNA and the gag-pol transcript of Human Immunodeficienc
70 In a hypomorphic murine model of PA, dual mRNAs normalize ammonia similarly to carglumic acid, a d
72 7 regulated the translation of E2F1 and E2F3 mRNAs through the 5' untranslated regions (UTRs) of E2F1
73 We observed that C/ebpalpha and C/ebpbeta mRNA and protein were markedly reduced in Src-1/-2 doubl
74 hemical modifications of adenine base editor mRNA and guide RNA expand the applicability of CRISPR-as
76 hese RBPs identifies thousands of endogenous mRNA targets that respond to changes in RBP level, recap
77 transcriptional program leading to enhanced mRNA translation and resulting in an increased PD-1 amou
78 ational repression but is required to enrich mRNAs in the germ lineage for robust germline developmen
79 ICH3 gene functionally and identified ERICH3 mRNA transcripts and protein isoforms that are highly ex
81 Cap structures are ubiquitous on eukaryotic mRNAs, essential for post-transcriptional processing, tr
84 the MTX infusion time (P = 1.5 x 10-3), FPGS mRNA expression (P = 2.1 x 10-3), and MTX systemic clear
86 genomic locations of SRTs are recovered from mRNA, and SRTs deposited by exogenous, TF-transposase fu
88 g wheel in their home cage increased galanin mRNA in the LC of mice, which was correlated with and co
90 ncreased the hypothalamic expression of Ghrh mRNA, although very few GHRH neurons were found to coexp
95 e mice silences miR-370-3p and restores HCN4 mRNA and protein and I(f) in the sinus node and blunts t
96 IFN-stimulated genes (ISGs) on hepadnaviral mRNAs transcribed from cccDNA, we found that downregulat
98 ovirus LOXL2 -treated implants showed higher mRNA levels of LOXL2, ACAN, and other anabolic genes com
99 ll lysis and mRNA capture, achieving highest mRNA detection accuracy (R = 0.955) and comparable sensi
101 HS2ST1 variants cause a reduction in HS2ST1 mRNA and decreased or absent heparan sulfate 2-O-sulfotr
103 conditions in vitro and analyzed changes in mRNA and protein levels to identify mechanisms of tumor
105 es responded differently to XRN1 deletion in mRNA synthesis and were differentially regulated by mRNA
111 stension of satellites (SADS) and p16(Ink4a) mRNA expression were identified in alveolar bone osteocy
113 in components, including: the first internal mRNA m7G database containing 44 058 experimentally valid
115 ing 44 058 experimentally validated internal mRNA m7G sites, a sequence-based high-accuracy predictor
118 ble to detect amplicons of 16S rRNA and katG mRNA generated from 0.1 pg and 10 pg total RNA taken for
119 (control-NM), in order to identify which key mRNA and microRNAs are regulating this complex process i
120 , localization, and local translation of key mRNAs in learning and memory and expand on the notion of
121 not only to a nonspecific depletion of KIF1A mRNA but also to an accelerated proteasomal degradation
122 e highly efficient at cis-cleaving mammalian mRNAs and showed that they can be tightly regulated by a
123 echanism of translational repression of manY mRNA by the sRNA SgrS through a binding interaction upst
125 orrespondingly, MKT1 is associated with many mRNAs, although not with those encoding ribosomal protei
127 q approach to explore the timing of maternal mRNA translation in quiescent oocytes as well as in oocy
129 NAs are natural products of RNase E-mediated mRNA decay and associate with major RNA-binding proteins
133 retained only 31 explanatory striatal miRNA-mRNA pairs that are precisely associated with the shape
135 In cancer cell lines and xenograft models, mRNA and protein expressions of the type I IFN pathway w
137 ggest that the use of gB nucleoside-modified mRNA-LNP vaccines is a viable strategy for improving on
138 ructures of its functional complexes with mt-mRNA, mt-tRNAs, recycling factor and additional trans fa
139 IL-17 each suppressed Il25, Il33, and muc5ac mRNA expression in cultured airway epithelial cells.
140 icing defect, we tested wild-type and mutant mRNA substrates, containing 333 nt of the C8alpha intron
142 rmore, we tested the effects of KIF3B mutant mRNA expression in the developing zebrafish retina.
145 berrantly counted along with a cell's native mRNA and result in cross-contamination of transcripts be
146 ocyte stress (Urinary pellet podocin:nephrin mRNA ratio), podocyte detachment (Urinary pellet podocin
155 d facilitates 3'->5' exosomal degradation of mRNA during ribosome-associated mRNA surveillance pathwa
156 Thus, EDC4 not only serves as an enhancer of mRNA turnover that binds DCP2, but also as a repressor t
157 scriptome studies involve the examination of mRNA transcript abundance and gene expression patterns i
162 ge of long reads spanning the full length of mRNA transcripts, we provide support for 23,865 splice i
163 Here, we integrate genome-wide measures of mRNA expression, miRNA expression, DNA methylation, and
164 t is therefore important that the process of mRNA translation remains in excellent synchrony with cel
165 ription factors assemble on the promoters of mRNA genes to form large macromolecular complexes that i
166 ed system for simultaneous quantification of mRNA and protein of a given gene via dual fluorescent re
168 ns and ER stress, leads to the regulation of mRNA stability and protein synthesis through posttranscr
170 its unique function in the stabilization of mRNA, which is associated with inflammatory autoimmune d
173 These include the nuclear accumulation of mRNAs encoding components of the negative limbs of the c
176 NP granules differentially controls fates of mRNAs localized within the same cytoplasmic domain.
178 vironmental changes, including regulation of mRNAs that require extensive uridine insertion/deletion
180 ned within the first five codons of a set of mRNAs that are enriched for translational enhancer seque
181 pression of functionally coordinated sets of mRNAs and involves combinatorial and dynamic interaction
183 strength of stabilizing selection acting on mRNA levels in a species is strongly associated with tha
185 Importantly, the polarity of ribosomes on mRNAs encoding multiple TMDs was disproportionately affe
186 PC, alters core clock gene expression and/or mRNA accumulation in a way that favors bacterial growth
189 ere found to bind cooperatively to the PDCD4 mRNA and mitigate miR-21-mediated translation repression
191 temperatures decreased (P = 0.026) placental mRNA expression of a glucose transporter (GLUT-3) and in
192 podocyte detachment (Urinary pellet podocin mRNA:creatinine ratio: UPPod:CR) and a tubular marker (U
194 s of piRNAs in humans is posttranscriptional mRNA silencing, their functions are similar to what we h
196 bryonic day 13-13.5 (E13-13.5) corrected pre-mRNA splicing in the juvenile Usher syndrome type 1c (Us
197 icroscopy and ability to support histone pre-mRNA processing in the presence of polyadenylation facto
199 ecific RNA-target sequences and modulate pre-mRNA splicing by sterically blocking the binding of spli
204 ns introduced by mis-splicing of PgABCA2 pre-mRNA were prevalent in field-selected larvae from India
207 rescue disease-relevant splicing of tau pre-mRNA in a variety of cellular systems, including primary
208 mpounds are shown to directly target tau pre-mRNA in cells, via chemical cross-linking and isolation
209 g the binding of splicing factors to the pre-mRNA, are a promising therapeutic modality to treat a ra
210 Because the majority of genes undergo pre-mRNA splicing, most cellular processes depend on proper
212 ntial role in the selection of the precursor mRNA branch-site adenosine, the nucleophile for the firs
215 assays reveal that QKI-7 binds and promotes mRNA degradation of downstream targets CD144, Neuroligin
217 We show here that CP33B is bound to psbA mRNA in vivo, as was shown previously for CP33C and SRRP
219 g the many cellular mechanisms that regulate mRNA fate, covalent nucleotide modification has emerged
222 Moreover, in TPR-depleted cells reporter mRNAs generated from short transcripts accumulate in nuc
224 (miRNA) target sites within a messenger RNA (mRNA) can act cooperatively, leading to more repression
225 is regulated at the level of messenger RNA (mRNA) translation during human hematopoietic development
227 We analyzed BE tissues for messenger RNAs (mRNAs) that associate with BE progression and identified
228 ng interactions with the 3' end of 16S rRNA, mRNA Shine-Dalgarno (SD) sequences positioned upstream o
230 egulators, while also destabilizing sentinel mRNAs that are primed to activate rescue pathways when m
231 r of target of Myb protein 1 (Stm1; SERPINE1 mRNA-binding protein 1 [SERBP1] in mammals), and recentl
233 driver genes were concatenated into a single mRNA construct to vaccinate patients with metastatic gas
236 tein levels by decreasing the amount of SNCA mRNA loaded into polysomes, mechanistically providing a
239 by nsun-1 depletion, translation of specific mRNAs was remodeled leading to reduced production of col
240 ochemistry and live-cell imaging of specific mRNAs, we describe for the first time the subcellular lo
242 , we found a global stabilization of spliced mRNAs upon T cell activation, although the stability of
243 the present study, we evaluated tissue SPP1 mRNA and OPN protein expression as markers of recurrence
244 As and their target mRNAs, facilitating sRNA-mRNA annealing, typically resulting in translation inhib
245 hin infected cells, EBOV downregulates STAT1 mRNA and interferon signaling, and it upregulates putati
249 d in the coding region and reduce the target mRNA by RNase H1 while the mRNA resides in the ribosomes
250 ly, leading to more repression of the target mRNA than expected by independent action at each site.
253 s) efficiently inhibit translation of target mRNAs by forming a duplex that sequesters the Shine-Dalg
254 nd that it accelerates degradation of target mRNAs, mediated by three N-terminal Repression Domains (
255 ore, a total of four miRNAs and their target mRNAs were predicted to involve in synthesis of melanin,
256 nally by binding small RNAs and their target mRNAs, facilitating sRNA-mRNA annealing, typically resul
258 definitive functions for endogenous targeted mRNAs and their relevance to modulation of in vivo tissu
260 native lengthening of telomeres (ALT)], TERT mRNA expression by RNA-sequencing, whole-genome/exome se
267 IKZF3 was unable to upregulate IL-10 at the mRNA or protein level in CD4(+) T cells and did not driv
269 n content associated with loss of eIF4E, the mRNA 5'-cap binding protein of the initiation complex an
271 elicase Ski2 binds to 80S ribosomes near the mRNA entrance and facilitates 3'->5' exosomal degradatio
272 tions causing nonsense-mediated decay of the mRNA leads to a wide spectrum of clinical phenotypes inc
274 he nucleus where it selectively binds to the mRNA processing protein, heterogeneous nuclear ribonucle
277 ng cell states during development from their mRNA profiles provides insight into their gene regulator
278 a few hours after inoculation and that their mRNAs are also detectable in roots and pods, which clear
281 y, tissue hydroxyproline content, and tissue mRNA expression of fibrosis-associated genes (Ccl11, Il1
282 use of poly-dT primers to reverse transcribe mRNA, followed by linear amplification through in vitro
284 ful control of the amounts of transcription, mRNA, and proteins made by key brain genes-stoichiometry
286 ation apparatus (composed of ribosome, tRNA, mRNA, and translation factors) and regulates crucial ste
287 find that WIN preexposure blunts the typical mRNA response to cocaine and instead results in alternat
292 for its function in the modulation of viral mRNA processing and viral DNA replication.IMPORTANCE Hum
295 NA for GATA3 and IL-5 correlated better with mRNA for CD30, TNFR2, ICOS, CCR4, and CD200R1 than for C