ライフサイエンスコーパス: macrocycle

1 cted by annulation of an intact tetrapyrrole macrocycle.

2 to establish three H-bonds with the ethereal macrocycle.

3 ecular cyclization leading to a new class of macrocycle.

4 duces CPL responses of opposite signs on the macrocycle.

5 to the position of a threaded benzylic amide macrocycle.

6 ng in water as compared to the biotin[6]uril macrocycle.

7 ional reorganizations of remote regions of a macrocycle.

8 nt of a fluorene moiety with the rest of the macrocycle.

9 f aromaticity and conjugation pathway in the macrocycle.

10 ed within the binding pocket of the DOTP(8-) macrocycle.

11 ce of less than 1 equiv of CF(3) CO(2) H per macrocycle.

12 en investigated and compared with the [8]CPP macrocycle.

13 , as well as the peripheral positions of the macrocycle.

14 onic behavior of the resulting tetracationic macrocycle.

15 ed 13-membered macrocycle to the 12-membered macrocycle.

16 ors, or by adjusting the global shape of the macrocycle.

17 functionality and cyclized the depsipeptidic macrocycle.

18 nitride complex supported by a redox-active macrocycle.

19 ith precise control over the position of the macrocycle.

20 operties that vary with the structure of the macrocycle.

21 ee-dimensional library of composite peptidic macrocycles.

22 -N-C material and prototypical pyrrolic iron macrocycles.

23 ent of optimized linkers in the synthesis of macrocycles.

24 s of the structure-based design of synthetic macrocycles.

25 ar, threefold symmetric, viologen-containing macrocycles.

26 t was inaccessible using only C(3)-symmetric macrocycles.

27 d groups and a pair of pai-stacked cyanostar macrocycles.

28 bust nanotubes from synthetically accessible macrocycles.

29 formations of constrained peptides and other macrocycles.

30 to elucidate the structural features of the macrocycles.

31 individual conformers compared to the parent macrocycles.

32 for protonated dithia-bis(calix)-sapphyrins macrocycles.

33 ited state are preserved in the low-symmetry macrocycles.

34 er cells were used to design next generation macrocycles.

35 the N-confused N-methyl pyrrole rings of the macrocycles.

36 not to the behavior of cyclic oligomers, aka macrocycles.

37 whether Huckel's rule extends to much larger macrocycles.

38 ed to arrive at the proposed geometry of the macrocycles.

39 re-permeability relationship of semipeptidic macrocycles.

40 sition to the results obtained for analogous macrocycles.

41 etic modifications in pursuit of non-racemic macrocycles.

42 variety of small-molecule ligands, including macrocycles.

43 ges, covalent organic frameworks (COFs), and macrocycles.

44 ps together and produce structurally diverse macrocycles.

45 th Cl(-) was found to be tailor-made for the macrocycle 1, while 1 + SA(-) (SA(-) = salicylate anion)

46 Moreover, pyridine-based macrocycle 19, possessing the phenylimidazole carboxamid

47 Three topoisomers-an unknot (0(1)) macrocycle, a trefoil (3(1)) knot(6-15), and a three-twi

48 maging of two additional sequence-controlled macrocycles (AAD, ABE) allowed us to identify the factor

49 The DFT studies revealed that macrocycles adopt a highly folded half-chair conformatio

50 leads to thermally stable cis isomers, where macrocycles adopt a slipped cofacial mutual geometry wit

51 The T2DIR spectra indicate that the macrocycle adopts a boat-like conformation at the final

52 The dimeric macrocycle adopts a columnar packing motif in the solid

53 se of a geometrically flexible, dinucleating macrocycle allows for the formation of a bridging N(2) l

54 cterial photosynthesis, include creating the macrocycle along with the trans-dialkyl substituents in

55 These peptides and macrocycles, along with the dimeric model of LDH-H, cons

56 ns two sequential four amino acid sactionine macrocycles, an unusual topology for this compound famil

57 actions between the pyridine moieties of the macrocycle and 1,4-diiodobutadiyne is predicted by densi

58 ins a bicyclic structure composed of a large macrocycle and a unique side-ring system containing a 3,

59 ations that alter the oxidation state of the macrocycle and also modify its size, its side-chain comp

60 The chlorophyll skeleton contains a chlorin macrocycle and an annulated fifth (or isocyclic) ring be

61 Dihydromotuporamine C contains a large macrocycle and an appended polyamine component and was s

62 A naphthalenediimide-based triangular macrocycle and coronene form selectively two co-crystals

63 A 2:1 stoichiometry between macrocycle and diphosphate produces a supramolecular hom

64 ates with all four nitrogen atoms of the TPP macrocycle and interacts with a silver atom of the subst

65 ue to challenges associated with 12-membered macrocycle and modified pyridine synthesis.

66 ng of small anions to the electron-deficient macrocycle and molecular model compounds is investigated

67 r from the same glycol-substituted cyanostar macrocycle and phenylene-linked diphosphate monomers.

68 e AD and BC halves, forming both the chlorin macrocycle and the isocyclic ring in a single-flask tran

69 ry amines, leading to fully organic covalent macrocycles and cages that were inaccessible through oth

70 nthesis of phthalocyanine as well as related macrocycles and chelates such as hemiporphyrazine and bi

71 op structures present in alpha-peptoid-based macrocycles and classify them according , psi, and omega

72 Macrocycles and cyclic peptides are increasingly attract

73 These methods create macrocycles and embed condensed heterocycles to diversif

74 For imine macrocycles and for the hydrochloride derivatives of mac

75 Covalent macrocycles and three-dimensional cages were prepared by

76 ers are possible: two S(n) symmetric achiral macrocycles and two macrocycles that are "inherently" ch

77 tion (pre- and post-formation of the chlorin macrocycle) and position of the xanthene backbone about

78 he isocyclic ring), S(E)Ar (to construct the macrocycle), and 2e(-),2H(+) oxidation (to give the arom

79 ed of a triphenylamine-substituted cyanostar macrocycle, and it exhibits a remarkable Stokes shift of

80 hat pai-conjugation extends around the whole macrocycle, and that it has a smaller HOMO-LUMO gap than

81 rce a relatively wide separation between the macrocycle anthracene sidewalls.

82 distinct dikeophosphanyl moieties within the macrocycles appear effectively "insulated" by the macroc

83 cyclic imine or bigger mixed 4 + 2 + 2 imine macrocycle are formed selectively.

84 op [2]rotaxanes, which owing to the pai-rich macrocycle are highly emissive.

85 is that in conformationally suitable systems macrocycles are an analog class worthy of consideration.

86 Macrocycles are appealing drug candidates due to their h

87 The macrocycles are assembled efficiently as a consequence o

88 Conjugated aromatic macrocycles are attractive due to their unique photophys

89 These macrocycles are comprised of glycoluril oligomers linked

90 acyclic molecules, these interactions within macrocycles are coupled such that changing one dihedral

91 tional dispositions of redox-active units in macrocycles are key to achieving high energy density and

92 tudies on synthetic drug-like small-molecule macrocycles are limited, and our current understanding o

93 Most macrocycles are made from a simple repeat unit, resultin

94 Nevertheless, these macrocycles are not enough to produce a high reaction ra

95 The resulting macrocycles are planar (2 degrees structure) and form H-

96 adj-dicarbaporphyrinoids indicate that these macrocycles are slightly diatropic.

97 ogenerated radical cations, intrinsic to TPA macrocycles, are altered upon their self-assembly into o

98 ur peripheries of eclipse-arranged porphyrin macrocycles, are successfully constructed through a top-

99 hat directs the assembly of a benzylic amide macrocycle around the axle to form [2]rotaxanes in up to

100 n obtained by clipping different tetralactam macrocycles around a 1.9 nm dumbbell-shaped nitrogenated

101 s incorporating phthalocyanine and porphyrin macrocycles as hole- and electron transporting materials

102 ic and hexameric S- and Se-bridged inorganic macrocycles based on cyclophosphazane frameworks, using

103 The novel title macrocycles, based on methylene-bridged 1,5-naphthalene

104 Within this context, macrocycle-based host-guest interactions are of particul

105 atic interactions, hydrophobic interactions, macrocycle-based host-guest interactions, among others.

106 r polymeric materials that rely primarily on macrocycle-based host-guest interactions.

107 cropollutant guests as the result of tunable macrocycle-based host-guest interactions.

108 nthesis of BChl a by preparation of a hybrid macrocycle (BC-1), which contains a trans-dialkyl group

109 e four carbon-carbon triple bonds produced a macrocycle bearing a carbon framework of [16]cyclophenac

110 nt units to an otherwise achiral crown ether macrocycle bearing a luminescent 2,2'-bipyrene unit when

111 cteriochlorophylls contain a bacteriochlorin macrocycle bearing an annulated fifth ring.

112 (Pc-ene1) and azaphthalocyanine (AzaPc-ene1) macrocycles bearing dual directional (up/down) allyl moi

113 erein, new synthetic strategies for four new macrocycles bearing the electron-withdrawing groups CN,

114 due to the disruption of conjugation of the macrocycle because of the presence of two sp(3) meso-car

115 etone redox interconversion which switches a macrocycle between a large or small cavity, with erect a

116 iastereoselective one-pot synthesis from the macrocycle biotin[6]uril.

117 mbering), were incorporated into the peptide macrocycles c[Pro(1)-Arg(2)-Phe(3)-Phe(4)-Xaa(5)-Ala(6)-

118 tructure and photophysical properties of the macrocycles came from fluorescence, time-correlated sing

119 The macrocycle can be selectively switched (with light in on

120 natively, affinity capture beads coated with macrocycle can be used to immobilize the liberated squar

121 latively small structural modifications to a macrocycle can result in local conformational changes th

122 The macrocycle can shuttle between an initial succinamide st

123 meric amino acid/nucleobase self-replicating macrocycles capable of exponential growth.

124 d was enhanced when Q(+) could penetrate the macrocycle cavity and engage in attractive noncovalent i

125 that the chalcogen atoms oriented within the macrocycle cavity are able to chelate copper(I) endotopi

126 as near the end of a flanking chain, and (b) macrocycle cavity size, which was enhanced when the cavi

127 0 % ee with switching of the position of the macrocycle changing the handedness of the product formed

128 cine, with naturally occurring and synthetic macrocycles clinically approved for use as prescription

129 ompared to the non-interlocked free axle and macrocycle components.

130 Azacalixquinarenes, a new family of macrocycles composed of diaminobenzoquinone diimine unit

131 ting diode (OLED) device fabricated with the macrocycle compound as the emitter has achieved a high e

132 Macrocycles, compounds containing a ring of 12 or more a

133 ptor-donor-acceptor (D-A-D-A) pai-conjugated macrocycle comprised of two U-shaped electron-acceptors

134 d an antagonist, which was distinct from the macrocycle conformation in the less-potent AgrC-I modula

135 he effects these derivatizations have on the macrocycle conformation, and how that affects their opti

136 These macrocycles consist of two TPAs and two methylene ureas,

137 ursor, leading to a dehydrobenzo[32]annulene macrocycle containing four carbon-carbon triple bonds.

138 six/eight cyclopenta-rings are fused onto a macrocycle containing three/four alternately linked 2,7-

139 ls can assemble bifunctional components into macrocycles containing multiple transient bonds.

140 Macrocycle-containing covalent polymer networks have beg

141 of organic micropollutants from water using macrocycle-containing covalent polymer networks.

142 potential and mode of action of the peptidic macrocycle CXCR4 antagonist POL5551 in mice with reperfu

143 s of complexation between an all-hydrocarbon macrocycle, D(4d)-CDMB-8, and perylene.

144 ds, and lower acid loadings instead catalyze macrocycle degradation.

145 system constructed from hydrogen-bonded azo-macrocycles demonstrates precisely controlled propensity

146 esent in many natural products and synthetic macrocycles designed against a particular biochemical ta

147 The position of the macrocycle dictates the facial bias of the rotaxane-cata

148 Most, but not all, macrocycle drugs are derived from natural products.

149 re limited, and our current understanding of macrocycle drugs is similarly limited.

150 own that the constriction of the axle by the macrocycle during the elongation of the rotaxane provoke

151 Upon protonation, the macrocycles exhibited bathochromically shifted absorptio

152 The reaction generated peptide macrocycles featuring a 4-imidazolidinone in their scaff

153 s, and, increasingly, these shape-persistent macrocycles find uses in host-guest chemistry and self-a

154 study measured the affinity of a tetralactam macrocycle for 11 different Q(+).Cl(-) salts in chlorofo

155 led a striking requirement for a low-entropy macrocycle for activity.

156 All P(4)N(2) macrocycles form square-planar nickel(II) complexes with

157 Here, we present a bioinspired strategy for macrocycle formation through carbon-carbon bond formatio

158 The results indicate that semipeptidic macrocycles generally possess high passive permeability

159 and five cyanostilbene acceptor units of the macrocycle generate an emissive CT state.

160 pen-source platform, CPMG (Composite Peptide Macrocycle Generator), has algorithmically generated a l

161 cycles appear effectively "insulated" by the macrocycle geometry, rather than acting as a through-con

162 which are situated at opposite sides of the macrocycle, gives versatile prerotaxane building blocks.

163 The 18-membered macrocycle H2 macropa was investigated for (225) Ac chel

164 Surprisingly, this important natural macrocycle has evaded molecular scrutiny, and its specif

165 his promise, the synthesis of collections of macrocycles has been historically challenging due to dif

166 Two shape-persistent arylene ethynylene macrocycles have been designed and synthesized as scaffo

167 Macrocycles have long been recognized as useful chemical

168 Peptidomimetic macrocycles have the potential to regulate challenging t

169 the cycloaddition reactions involving those macrocycles having more strained alkynes not only are mo

170 ic focus is placed on the development of new macrocycle hosts since 2010, coupled with considerations

171 have made it possible to obtain the desired macrocycles in excellent yields.

172 Interest is growing in the use of macrocycles in pharmaceutical discovery.

173 profiles, as well as the organization of the macrocycles in the crystalline state, are strongly deter

174 s the hierarchical assembly of nonbiological macrocycles, in this case, at graphite surfaces.

175 The isomeric macrocycles incorporated with interesting optical proper

176 The triangular macrocycle, incorporating three PMDI units in close prox

177 Both rotaxanes consist of a tetra-amide macrocycle interlocked onto a polyether axle.

178 The incorporation of supramolecular macrocycles into porous organic polymers may endow the m

179 tor stabilizing only one conformation of the macrocycle, irrespective of the stereoisomer used for th

180 Translocation of the macrocycle is controlled by a hydrogen-bonding equilibri

181 o CH-hydrogen-bond to halide anions when the macrocycle is located on an alternative (ammonium) bindi

182 ing capture, the fluorescence of the alcohol macrocycle is quenched via fluorescent photoinduced elec

183 of an antioxidant-substituted resorcinarene macrocycle is reported.

184 The conformational analysis of macrocycles is a complex and challenging problem.

185 The efficient preparation of macrocycles is a fundamental challenge in synthetic orga

186 The synthesis of macrocycles is severely impeded by concomitant oligomer

187 bsorption in neutral and protonated forms of macrocycles is the important highlight of this article.

188 CEt(3))(1)]BF(4) (5) (1 is a chiral N(2)P(2) macrocycle) is the catalytically active species in the a

189 d with two smaller isophthalamide-containing macrocycles, is constructed using an anion template synt

190 rom from the 4 central nitrogens of the H(B) macrocycle-is the key additional mutation providing 90%

191 Using microarrays of a library of new macrocycles known as rapafucins, which were inspired by

192 teins do not provide a useful guide: Peptide macrocycles lack regular secondary structures and hydrop

193 ctron-acceptor interaction of diastereomeric macrocycles, leading to structurally distinct pseudorota

194 C (3) showed an unprecedented tetronate-less macrocycle-less structure, which was likely produced fro

195 within the field of DOS for the synthesis of macrocycle libraries, utilizing modern synthetic methodo

196 Usually the weak stacking energies of macrocycles limit the length and mechanical strength of

197 The binding constant for the macrocycle-monomer complex (K = 10.5 L mol(-1)) is much

198 thesized a 45,000-compound library of hybrid macrocycles (named rapafucins) using optimized FKBP-bind

199 nd complexation studies of perylene bisimide macrocycles obtained through bayside coupling.

200 the hydroquinone unit and the oxidized metal macrocycle occurs.

201 ingly, a unique beta-turn was present in the macrocycles of the two most potent AgrC-I modulators, in

202 he stimuli-induced change of position of the macrocycle on the rotaxane thread.

203 e switching of the position of a fluorescent macrocycle on the thread turns "on" or "off" the circula

204 geometrically distinct, pentacene-containing macrocycles on a gram scale and in four or fewer steps.

205 The pai-pai stacking orientation of these macrocycles on the perovskite surface is important in fa

206 dicarboxylic acids give aqueous dianhydride macrocycles on treatment with a carbodiimide.

207 mergence of a unprecedentedly large range of macrocycles or to molecular specificity, i.e., the autoc

208 usual host-guest chemistry of the pentameric macrocycle [{P(mu-N(t) Bu}(2) NH](5) with a range of ani

209 y due to an early transition state where the macrocycle partially hydrogen bonds to the ether group o

210 port a molecular pyridinic hexaazacyclophane macrocycle, (phen(2)N(2))Fe, and compare its spectroscop

211 Unlike the pyrrolic macrocycles, (phen(2)N(2))Fe displays excellent selectiv

212 Thus, within [4]- and [6]-membered macrocycles, poly-zwitterionic structures can be reached

213 olecular luminescent chemosensors, including macrocycles, polymers, and nanomaterials.

214 sitting on top of one another at one of the macrocycle portals.

215 between 8 and 10 ppm, demonstrating that the macrocycles possess significant 14pai electron diamagnet

216 d substitutions within the beta-turns of the macrocycle preserved the rigidity of the parent scaffold

217 The cavity size of the macrocycle prevents the formation of a linear Fe-N(2)-Fe

218 fold in the axis of a 30-membered all-carbon macrocycle provides access to a modular series of rotaxa

219 These compounds are members of polyene macrocycles, pyrroloindole alkaloids, angucyclines, and

220 ence controls the hierarchical patterning of macrocycles raises the importance of stepwise syntheses

221 ted anions) toward a model tetralactam-based macrocycle receptor (1), defined in terms of stability o

222 Taken together, our studies suggest that macrocycles represent a promising class of compounds for

223 from pre-existing ligand coordinates of 150 macrocycles resulted in occupancy-weighted conformationa

224 STM imaging of an AAB macrocycle revealed the formation of a new gap phase tha

225 attractive noncovalent interactions with the macrocycle's NH residues and aromatic sidewalls.

226 ration and also inspire the design of future macrocycle screening collections.

227 tructures for the free base form of both the macrocycles showed absolute planar geometries without an

228 The macrocycles showed one broad absorption band at ~553 nm

229 The macrocycles showed one sharp Soret-type band at approxim

230 recognition sites produces a small-amplitude macrocycle shuttling motion, from the viologen to the me

231 However, the notion of macrocycles simply as privileged scaffolds that primaril

232 An array of RGD peptides differing in macrocycle size, the presence of d-amino acid, N-methyla

233 conditions, the C-terminal residue, and the macrocycle size.

234 A series of nanocarbons with different macrocycle sizes and heteroatom content have been prepar

235 ested the uptake of linear peptides, peptide macrocycles, stabilized helices, beta-hairpin peptides,

236 umber of currently available unbound peptide macrocycle structures.

237 Mixed-chirality peptide macrocycles such as cyclosporine are among the most pote

238 ables the chiral information transfer to the macrocycle, switching "off" the CPL response.

239 Early innovations used the natural macrocycle tether of disulfide bond formation, metal-med

240 We report a chloride-selective tetraurea macrocycle that has a record-high H(+) /Cl(-) symport ac

241 cally shield the boron atoms, resulting in a macrocycle that is both highly electron-deficient and st

242 o S(n) symmetric achiral macrocycles and two macrocycles that are "inherently" chiral.

243 Herein, we report triamide macrocycles that are easily synthesized and externally f

244 Here we report pyridine-2,6-diimine-linked macrocycles that assemble into high-aspect ratio nanotub

245 mically generated a library of 2,020,794,198 macrocycles that can result from the multistep reaction

246 rmation, which is advantageous for preparing macrocycles that do not easily adopt a figure-of-eight g

247 thetic community has been pursuing synthetic macrocycles that have no precedent in nature.

248 C active sites relative to the pyrrolic iron macrocycles, thereby establishing a new molecular platfo

249 covalent complex composed of the tetralactam macrocycle threaded by a reactive benzylic cation.

250 Values of Ka and kon for macrocycle threading in water are reported for a series

251 end of the squaraine core that ensures fast macrocycle threading kinetics, and (c) sialic acid block

252 (c) sialic acid blocking groups that prevent macrocycle threading until they are removed by viral neu

253 ntene (OFCP) to afford atypically structured macrocycles through successive vinylic substitutions.

254 f base, the switching of the position of the macrocycle to a triazolium group disables the chiral inf

255 A computational study reveals the smallest macrocycle to have the most energetic VHF-VHF state and

256 ilability in the imidazole-based 13-membered macrocycle to the 12-membered macrocycle.

257 e-dimensional information from one side of a macrocycle to the other.

258 es ), which allows hexameric uranyl peroxide macrocycles to adopt the nanotubular topology and preven

259 drugs of cisplatin and perfluoroaryl peptide macrocycles to increase brain uptake.

260 finding raises the idea of using tetralactam macrocycles to stabilize fluoride-containing liquid elec

261 ting the ability of the 18-membered P(4)N(2) macrocycles to stereoisomerize in the course of the comp

262 The results demonstrate the ability of macrocycles to template water cavitation within their bi

263 ly N-confused porphyrins might entitle these macrocycles toward such applications.

264 binatorial library contains, amongst various macrocycles, two different types of [2]catenanes that ar

265 Both macrocycles undergo singlet fission in solution with rat

266 is reactions to form a topologically trivial macrocycle (unknot), a doubly interlocked [2]catenane (S

267 tructure cannot be threaded by a tetralactam macrocycle until the blocking groups are removed by enzy

268 chemical modifications to a natural product macrocycle upon its activity, 3D geometry, and conformat

269 osing metathesis system for the formation of macrocycles using a stereoretentive, ruthenium-based cat

270 modules that produce the 16-membered tylosin macrocycle, using them as biocatalysts in the chemoenzym

271 The macrocycle was demonstrated to exist as two locked confo

272 The obtained macrocycle was found to display a marked pH responsivene

273 erted from the macrocyclic framework and the macrocycle was nearly planar.

274 d electrochemical studies indicated that the macrocycle was nonaromatic in nature due to lack of conj

275 A lipophilic version of the tetralactam macrocycle was prepared and used to extract F(-) from wa

276 A neutral tetralactam macrocycle was prepared in a few minutes in one pot and

277 d by these hot spots, a library of drug-like macrocycles was docked and then screened for inhibition

278 homodimers of organophosphates and cyanostar macrocycles was investigated for the first time.

279 rins are nonaromatic, and pai-conjugation in macrocycles was limited due to nonplanar arrangement of

280 assess target selectivity in cells, selected macrocycles were analyzed for modulation of DNA damage.

281 These new fluorenophyrin macrocycles were characterized and studied by high-resol

282 The obtained 18-membered P(4)N(2) macrocycles were isolated in pure form as meso- (R(P)S(P

283 , or benzene, new families of porphyrin-like macrocycles were produced.

284 Imine-linked macrocycles were recently found to assemble into high-as

285 sequences encoded into the suite of tricarb macrocycles were shown by scanning-tunneling microscopy

286 In total, 47 macrocycles were synthesized using a hybrid solid-phase/

287 e consisting of a large four-station central macrocycle which incorporates a bay tetrachloro-function

288 ion of precursor molecules into six-membered macrocycles, which constitute the fibers.

289 studies on physicochemical properties of the macrocycle with a linear surrogate have revealed signifi

290 onditions favored the formation of the [4+4] macrocycle with an unprecedented geometry, as revealed f

291 n the meso-positions or the periphery of the macrocycle with total yields of 55-58%.

292 cycloparaphenylenes (CPPs)-shape-persistent macrocycles with built-in cavities and radially oriented

293 intramolecular hydrogen bonding and leads to macrocycles with conformationally rigid turn structures.

294 (speed bumps) on the flanking chains and two macrocycles with different cavity sizes.

295 al pH to form peptide-peptide intermolecular macrocycles with highly tunable ring sizes.

296 red through the coupling of arylenethynylene macrocycles with ODNs, which were used to mediate the as

297 To design macrocycles with one (AAA), two (AAB), or three (ABC) di

298 tronic properties and smooth, rigid pores of macrocycles with radially oriented pai systems render th

299 Amido-amine macrocycles with two and four naphthalimide dyes were de

300 The diheteroporphyrins, which are neutral macrocycles without ionizable protons, also showed inter