ライフサイエンスコーパス: macrocyclic

1 adecane (L1), a constitutional isomer of the macrocyclic [14]aneN(2)S(2) series, is accompanied with

2 Breakthrough reaction rates for macrocyclic (36%; 95% CI: 25%, 48%; 23 of 64 administrat

3 tating Phe(20) to cyclohexylalanine (Cha) in macrocyclic Abeta-derived peptides promotes crystallizat

4 P-based bridged Lewis pairs (BLPs) that form macrocyclic addition products.

5 to recent regulatory decisions, with use of macrocyclic agents almost exclusively in 2018 and 2019;

6 and gadobenate dimeglumine compared with the macrocyclic agents gadobutrol and gadoteridol.

7 o cause greater MRI signal changes than some macrocyclic agents, deposition of gadolinium has also be

8 on of gadolinium has also been observed with macrocyclic agents.

9 eactions, generating 14- to 21-membered ring macrocyclic alkenes in 40-70% yield and 96:4-98:2 Z:E se

10 them to be converted stereoselectively to E-macrocyclic alkenes.

11 This effort resulted in the discovery of a macrocyclic amide linker which was found to form a key h

12 icular, the crystals of protonated 4 + 2 + 2 macrocyclic amine, which contains two types of diastereo

13 les and for the hydrochloride derivatives of macrocyclic amines, their X-ray crystal structures have

14 ounds have been reduced to the corresponding macrocyclic amines, which have been further transformed

15 rationalize the selective binding between a macrocyclic analogue and the alpha9alpha10 nicotinic ace

16 Finally, we evaluated macrocyclic analogues of the BH3 domain of the BIM prote

17 Multiple macrocyclic analogues of the peptide transportan-10 were

18 Cyclophanes are a venerable class of macrocyclic and cage compounds that often contain unusua

19 Earth-abundant Fe, Ni, and Co aza macrocyclic and polypyridine complexes have been thoroug

20 His influence on macrocyclic and supramolecular chemistry has been pervas

21 c community and fueled important advances in macrocyclic and supramolecular chemistry.

22 theta (theta) defensin-1 (RTD-1), a natural macrocyclic antimicrobial peptide, was recently shown to

23 Confinement within the macrocyclic architecture slows the inversion of the o-ph

24 le benziporphyrins are essentially devoid of macrocyclic aromatic character, and azuliporphyrins fall

25 sentation for depicting the bonding of large macrocyclic aromatic compounds.

26 Macrocyclic arrangements of chromophores have been shown

27 mework of [16]cyclophenacene as the shortest macrocyclic belt-like structure of an (8,8)armchair carb

28 pend residues from Abeta(1-14) to the parent macrocyclic beta-hairpin peptide 1, which comprises Abet

29 We previously studied, in our laboratory, macrocyclic beta-hairpin peptides derived from Abeta(16-

30 allographic structures of hexamers formed by macrocyclic beta-hairpin peptides derived from the centr

31 X-ray crystallography reveals that the macrocyclic beta-sheet assembles to form double-walled n

32 r describes the supramolecular assembly of a macrocyclic beta-sheet containing residues 16-22 of the

33 n of residues 11-17 of IAPP (RLANFLV) into a macrocyclic beta-sheet peptide results in a monomeric pe

34 Structurally, chrysophaentin A features a macrocyclic biaryl ether core incorporating two trisubst

35 Here we report the discovery of a macrocyclic bis-thiourea derivative that catalyzes stere

36 Establishment of the conformation of the macrocyclic carbocation intermediate required to produce

37 6-dimethoxybenzyne to form the corresponding macrocyclic carbon frameworks.

38 during RiPP biosynthesis: installation of a macrocyclic carbon-carbon bond that links the unactivate

39 rative examples of cross metathesis with the macrocyclic catalyst are also provided.

40 aper substrate with a metalloporphyrin based macrocyclic catalyst ink that can electrochemically redu

41 eactions is attributed to the ability of the macrocyclic catalyst to differentiate alkenes based on t

42 ficantly changing the nature and size of the macrocyclic cavities.

43 Here, we report a macrocyclic chelate, [Mn(PC2A-BP)], which possesses high

44 ical shifts of non-exchangeable protons from macrocyclic chelates (e.g., DOTP(8-)) complexed with par

45 tissue concentrations of multiple linear and macrocyclic chelates in a rat model to better understand

46 Macrocyclic chelators have been widely employed in the r

47 By combining macrocyclic chemistry with density functional theory cal

48 dy underscores the future promise of p-block macrocyclic chemistry.

49 Here we show that macrocyclic cinnamate dimers combine these productive st

50 A novel planar and conjugated N(4) -macrocyclic cobalt complex (Co(II)CPY) derived from phen

51 we report the discovery of colibactin-645, a macrocyclic colibactin metabolite that recapitulates the

52 d that comprise heterodinuclear Co(III)/M(I) macrocyclic complexes (where M(I) = Group 1 metal).

53 Three paramagnetic Co(II) macrocyclic complexes containing 2-hydroxypropyl pendant

54 Comparison of four different Fe(III) macrocyclic complexes elucidates the factors that contri

55 Several reaction modalities of these macrocyclic complexes were uncovered.

56 oying a fumaramide thread as template of the macrocyclic component, this latter incorporating two car

57 ten critical in such cases: the potency of a macrocyclic compound can depend on the stereochemistry o

58 The macrocyclic compound displayed polymorphs-dependent conf

59 Each macrocyclic compound has been obtained as two enantiomer

60 The formed macrocyclic compound was able to revert to monomers unde

61 approach was used to synthesize a reversible macrocyclic compound.

62 Macrocyclic compounds are central to the development of

63 a novel family of constrained pseudopeptidic macrocyclic compounds containing the hexahydropyrrolo[3,

64 he cathodic voltammetric behavior of all the macrocyclic compounds containing two or more quinone uni

65 Modified tetrapyrroles are large macrocyclic compounds, consisting of diverse conjugation

66 crucial role in synthesizing the reversible macrocyclic compounds.

67 he beginning of research on cyclic polyether macrocyclic compounds.

68 ontrast agent) but not gadoterate meglumine (macrocyclic contrast agent) led to pain hypersensitivity

69 ed to multiple administrations of linear and macrocyclic contrast agents.

70 has been applied toward the synthesis of the macrocyclic core of complex pharmaceutical vaniprevir.

71 lyketide synthase (PKS) that synthesizes the macrocyclic core of the antibiotic erythromycin.

72 pared with the C2 side chain attached to the macrocyclic core structure by a C-C single bond, in plac

73 ve that our work will spur interest in using macrocyclic cores for in silico-based lead generation an

74 uest interaction of MPT was studied with two macrocyclic cucurbit[7,8]uril (CB[7,8]) hosts in water;

75 In this study, a set of macrocyclic cyclophilin inhibitors was synthesized based

76 Teixobactin, a macrocyclic depsipeptide natural product, isolated from

77 proach to discrete collections of oligomeric macrocyclic depsipeptides using an oligomerization/macro

78 ucturally and functionally distinct types of macrocyclic derivatives: (1) a figure-eight dimer via al

79 Structural studies showed that four macrocyclic diastereoisomers are possible: two S(n) symm

80 e voltage plateaus observed for a homologous macrocyclic dimer and an acyclic derivative of pyromelli

81 f Euphorbia lathyris L. contains a series of macrocyclic diterpenoids known as Euphorbia factors.

82 into next-generation BRAF inhibitors through macrocyclic drug discovery.

83 available metathesis approach for accessing macrocyclic E-olefins entails selective removal of the Z

84 cavity and hydrophilic external surface are macrocyclic entities that display a combination of molec

85 Macrocyclic enyne and dienyne complexes were readily syn

86 2(2-)) is unique in both the Pc and related macrocyclic (ex.

87 hown that one member of a class of high-spin macrocyclic Fe(III) complexes produces more intense cont

88 ally, we have identified a self-synthesizing macrocyclic foldamer with a complex and unprecedented se

89 trumental in the designing or redesigning of macrocyclic frames, particularly in the search for adjus

90 ed that the furan ring was inverted from the macrocyclic framework and the macrocycle was nearly plan

91 ue reactivity from a tunable, highly durable macrocyclic framework was studied via a series of photoc

92 ual advantages of combining compact pai-rich macrocyclic frameworks with mechanical bonds formed via

93 ssed using reductive N-S cleavage to furnish macrocyclic freebase L1.

94 A macrocyclic furan-containing CPP precursor was used for

95 A novel series of macrocyclic FXIa inhibitors was designed based on our le

96 f potent, orally bioavailable pyridine-based macrocyclic FXIa inhibitors.

97 The macrocyclic FXIa series, exemplified by compound 16, had

98 escribe ADx-001, an Abeta-targeted liposomal macrocyclic gadolinium (Gd) imaging agent, for MRI of am

99 ct of at least five serial injections of the macrocyclic gadolinium-based contrast agent (GBCA) gadot

100 who have undergone multiple studies with the macrocyclic gadolinium-based contrast agent gadoterate m

101 creases after repeated administration of the macrocyclic gadolinium-based contrast agents (GBCAs) gad

102 effect of more than 20 serial injections of macrocyclic gadolinium-based contrast agents (GBCAs) on

103 tate dimeglumine, gadobenate dimeglumine), a macrocyclic GBCA (gadobutrol, gadoterate meglumine, gado

104 xamine the association between the number of macrocyclic GBCA administrations and DeltanSIDN or Delta

105 ts The mean +/- standard deviation number of macrocyclic GBCA administrations was 22.2 +/- 10.6 admin

106 t not eliminated following administration of macrocyclic GBCA chelates in lieu of linear chelates.

107 ho had received 10-44 administrations of the macrocyclic GBCA gadobutrol (0.1 mmol/kg of body weight)

108 after a mean of 8.6 serial injections of the macrocyclic GBCA gadoterate meglumine in pediatric patie

109 ant linear association between the number of macrocyclic GBCA injections and DeltanSIDN (r = 0.69, P

110 cement was observed in the DN after multiple macrocyclic GBCA injections.

111 d in two patients who had received 37 and 44 macrocyclic GBCA injections.

112 e effect of repeated exposure to a linear or macrocyclic GBCA on gadolinium retention in the central

113 Gadopiclenol, a macrocyclic GBCA with at least twofold higher relaxivity

114 o are administered large cumulative doses of macrocyclic GBCA with breast MRI at high-risk breast can

115 ep brain nuclei after more than six doses of macrocyclic GBCA, this has not been explored in a health

116 dicates that 20 or more serial injections of macrocyclic GBCAs administered with on average 3 months

117 P < .00001) and less than that for nonionic macrocyclic GBCAs at 16 (95% CI: 14, 19) per 10 000 admi

118 ing for reference) with the exclusive use of macrocyclic GBCAs gadoterate meglumine and gadobutrol we

119 find this effect after serial injections of macrocyclic GBCAs in adults.

120 ultiple intravenous administrations of these macrocyclic GBCAs in children were not associated with a

121 The animals that received macrocyclic GBCAs showed an ongoing elimination of gadol

122 For macrocyclic GBCAs, the DCN-to-brainstem SI ratios did no

123 rison with those of ionic linear or nonionic macrocyclic GBCAs.

124 (GBCAs) but had received many injections of macrocyclic GBCAs.

125 who had received 37 and 44 standard doses of macrocyclic GBCAs.

126 s, encompassing derivatized polysaccharides, macrocyclic glycopeptides, iso-butylmercaptoquinine, iso

127 Thiopeptides are a broad class of macrocyclic, heavily modified peptide natural products t

128 s, becomes complexed with the tetra cationic macrocyclic host CBPQT(4+) , swelling occurred as a resu

129 h-affinity guests have been reported for the macrocyclic host cucurbit[7]uril (CB[7]), enabling wides

130 embly process of an enantiopure trianglimine macrocyclic host from gel to single crystals.

131 The synthesis of new cationic macrocyclic host molecules is described.

132 both the anion and the binding pocket of the macrocyclic host play important roles in the overall ene

133 he most recognizable supramolecular motifs - macrocyclic host-guest complexes - afford logical applic

134 cenylguanidinium derivative (FcG(+)) and the macrocyclic hosts cucurbit[7]uril (CB7) and cucurbit[8]u

135 These macrocyclic hosts exhibit a rare 2:1 host-guest stoichio

136 d binding of organic molecules by switchable macrocyclic hosts.

137 ng and -restricting structural elements into macrocyclic hot loop-derived peptides.

138 The macrocyclic hydroxamate-based pan-MMP inhibitor coupled

139 All macrocyclic imine compounds have been reduced to the cor

140 ding on reaction conditions, mixed 2 + 1 + 1 macrocyclic imine or bigger mixed 4 + 2 + 2 imine macroc

141 rochiral self-sorting of 2 + 2 and 2 + 1 + 1 macrocyclic imines has been confirmed by a competition r

142 led to the design and synthesis of the novel macrocyclic inhibitor 8 (cell IC(50) = 1.2 muM).

143 Grazoprevir is a potent pan-genotype and macrocyclic inhibitor of hepatitis C virus (HCV) NS3/4A

144 d cores led to the discovery of an uncharged macrocyclic inhibitor of the Keap1-Nrf2 protein-protein

145 nase domain in complex with a small-molecule macrocyclic inhibitor.

146 containing 4-amidinobenzylamide derivatives, macrocyclic inhibitors addressing nonprimed binding regi

147 high-resolution crystal structures of three macrocyclic inhibitors with low nanomolar or subnanomola

148 acrocycles, strained cycloalkynes, and a key macrocyclic intermediate toward the synthesis of aceroge

149 n proposed as contributors to the widespread macrocyclic lactone (ML) resistance in several nematode

150 Furthermore, a novel transport pathway for macrocyclic lactone entry into the environment was ident

151 ketide products harboring 14- to 16-membered macrocyclic lactone rings to which various sugars are at

152 Macrocyclic lactone treatments for livestock can have de

153 The 16-membered macrocyclic lactone was formed via ring closing metathes

154 or the determination of the residues of five macrocyclic lactones (MLs) (abamectin, doramectin, eprin

155 monomeric, dimeric, trimeric, and tetrameric macrocyclic lactones consisting of units of this prostag

156 Macrocyclic lactones ranging in size from twelve- to sev

157 Macrolactones, macrocyclic lactones with at least twelve atoms within t

158 The highly complex thiosemicarbazone-based macrocyclic libraries contain both [2]catenanes and sequ

159 an extended, pai-delocalized, tetra-amidate macrocyclic ligand (TAML) as water oxidation catalyst an

160 catalyst, [Ni(MeTAA)], featuring a tetraaza macrocyclic ligand (tetramethyltetraaza[14]annulene (MeT

161 dox-active bipyridyl- N-heterocyclic carbene macrocyclic ligand complexed with nickel, CO(2) is conve

162 Mn complex with concomitant assembly of the macrocyclic ligand into the 1,2,3,4,8,9,10,11-octaazacyc

163 The macrocyclic ligand is generated by the reductive couplin

164 nteraction, by the hexa-amide, hexaphenolate macrocyclic ligand tris-cyclo-salophen(12-).

165 lated Fe(TAML)-complexes (TAML = Tetra Amido Macrocyclic Ligand) can be used as cofactors for incorpo

166 he TAML scaffold in cobalt-TAML (tetra-amido macrocyclic ligand) complexes has been under debate sinc

167 Fe(V)(O)(TAML)](-) (5, TAML(4-) = tetraamido macrocyclic ligand).

168 observed upon oxygen incorporation into the macrocyclic ligand.

169 range of redox-inactive metals by a tailored macrocyclic ligand.

170 Herein, we report two 18-membered macrocyclic ligands called macrodipa and macrotripa that

171 Dicobalt complexes supported by flexible macrocyclic ligands were used to target the generation o

172 on the outer circumference of the respective macrocyclic ligands.

173 mbedded on the peripheries of the respective macrocyclic ligands.

174 mophoric interaction among the pi-conjugated macrocyclic linkers was studied within three tetraphenyl

175 ward the identification of a novel series of macrocyclic Mcl-1 inhibitors featuring an alpha-hydroxy

176 -space electron delocalization in triangular macrocyclic molecules that exhibit a single well-defined

177 tems have emerged only recently as promising macrocyclic molecules to fabricate environmentally benig

178 deliver structurally diverse collections of macrocyclic molecules, and the exploration of their ther

179 The strained triple bonds of a macrocyclic monomer serve both as the site of polymeriza

180 for the ring-opening polymerization of large macrocyclic monomers.

181 tion by four deprotonated amide nitrogens in macrocyclic motifs is the signature of TAMLs where the m

182 we applied binding site hotspot mapping to a macrocyclic natural product and extracted precise struct

183 r the immunosuppressant rapamycin, a complex macrocyclic natural product that forms a ternary complex

184 Streptide (1) is a peptide-derived macrocyclic natural product that has attracted considera

185 Here, we describe how cores of macrocyclic natural products can serve as a high-quality

186 Rapamycin and FK506 are macrocyclic natural products with an extraordinary mode

187 polymerization kinetics were due to the cis-macrocyclic olefin being less flexible and having a larg

188 eptides, iso-butylmercaptoquinine, isopropyl macrocyclic oligosaccharides, and pai-electron acceptor/

189 owed access to countless biologically active macrocyclic organic molecules, even for large-scale prod

190 en the {Mo(3)S(4)} core and the redox-active macrocyclic {P(8)W(48)} polyoxometalate (POM) produces a

191 upon hydrolysis produces a rare example of a macrocyclic paraphenylene 6 incorporating the versatile

192 Macrocyclic PepNats representing hot loops of inducible

193 Based on this screen, a macrocyclic peptide 22 involving two non-natural amino a

194 The crystal structure of an iPGM macrocyclic peptide complex illuminated an allosteric, l

195 ers contain a sequence that is released as a macrocyclic peptide during post-translational processing

196 Indeed, we observed that a macrocyclic peptide formed by ReACT stapling at methioni

197 es by exploiting the reactivity of transient macrocyclic peptide imines toward inter- and intramolecu

198 Using this approach, an optimized macrocyclic peptide inhibitor (HL2-m5) was obtained that

199 Herein, we have engineered a macrocyclic peptide inhibitor of activated FXII (FXIIa)

200 re we tested the effect of RA101295, a 2-kDa macrocyclic peptide inhibitor of C5 cleavage, using in v

201 e ability to incorporate dehydroalanine into macrocyclic peptide ions, which is easily accomplished t

202 chains for screening against trillion-member macrocyclic peptide libraries (RaPID system).

203 II PCCs, which are typically developed from macrocyclic peptide libraries and are precisely epitope-

204 affinity maturation through the screening of macrocyclic peptide libraries produced in E. coli cells.

205 ich lariat-like ligands from an mRNA-display macrocyclic peptide library containing >10(12) members.

206 This first-in-class macrocyclic peptide modulator of the hedgehog pathway is

207 y common constituents of naturally occurring macrocyclic peptide molecules.

208 The NMR structure of the macrocyclic peptide overlays well with that of alpha-RgI

209 -methyl-thioamide bonds in linear as well as macrocyclic peptide scaffolds in the mRNA-dependent mann

210 This strategy resulted in the design of a macrocyclic peptide that competes with the LDH tetrameri

211 This strategy led to the discovery of macrocyclic peptide-peptoid hybrids with high CXCR7 bind

212 sunflower proalbumins into an albumin and a macrocyclic peptide.

213 These macrocyclic peptides are around 30 amino acids in size a

214 s Review explores the class of plant-derived macrocyclic peptides called cyclotides.

215 Large macrocyclic peptides can achieve surprisingly high membr

216 Macrocyclic peptides can interfere with challenging biom

217 the stable structures that can be adopted by macrocyclic peptides composed of l- and d-amino acids by

218 tory has previously designed and synthesized macrocyclic peptides derived from Abeta(17-23) and Abeta

219 This Review is devoted to the chemistry of macrocyclic peptides having heterocyclic fragments in th

220 efforts highlighting the important roles of macrocyclic peptides in expanding chemical diversity for

221 rotected N-acyl urea-linked peptides to form macrocyclic peptides mediated by N-terminal cysteine.

222 Macrocyclic peptides provide a potential solution to the

223 These are macrocyclic peptides showing promising antitumor activit

224 cking that allows the affinity maturation of macrocyclic peptides taking non-natural amino acids into

225 escribed through the design and synthesis of macrocyclic peptides that bind with high affinity to BRA

226 Structural interrogation of the linear and macrocyclic peptides using variable-temperature NMR and

227 ficient and mild method for the synthesis of macrocyclic peptides via nitrogen arylation from unprote

228 ented workflow allows the screening of large macrocyclic peptides with diverse modifications thereby

229 ADME properties into both rigid and flexible macrocyclic peptides, and that scaffold rigidity can be

230 A library of more than 30 macrocyclic peptidomimetic inhibitors was employed for s

231 ein the design, synthesis, and evaluation of macrocyclic peptidomimetics that bind to WD repeat domai

232 By use of a macrocyclic phosphinite pincer ligand and bulky substrat

233 based on alkali metal cation binding with a macrocyclic "pincer-crown ether" ligand.

234 sent the synthesis and characterization of a macrocyclic polyamide cage that incorporates redox-activ

235 R252922, and FR256523 are a family of potent macrocyclic polyene immunosuppressive agents with a nove

236 Mandelalides A-D (1-4) are macrocyclic polyketides known to have an unusual bioacti

237 his study has revealed the 3D structure of a macrocyclic precursor protein and provided important mec

238 The required macrocyclic precursor was prepared by ring-closing alkyn

239 Nanotubes assembled from macrocyclic precursors offer a unique combination of low

240 Nafion-H, leading (apart from polymers) to a macrocyclic product with a rearranged basic skeleton.

241 the energy barrier for the formation of the macrocyclic product.

242 Macrocyclic products bearing non-native and rigidifying

243 The macrocyclic products were highly diatropic and produced

244 These macrocyclic products were isolated in a monoprotonated f

245 ein, we report the design and synthesis of a macrocyclic PROTAC by adding a cyclizing linker to the B

246 enabled the synthesis of potent pyridone and macrocyclic pyridone inhibitors exhibiting single digit

247 tegic design and synthesis of a novel large, macrocyclic receptor composed of two covalently strapped

248 try, based on the development of a myriad of macrocyclic receptors with fine-tuned affinities and sel

249 rophobic cross-linkers stabilize the fold by macrocyclic restraints, and they also form an integral p

250 In the absence of macrocyclic ring constraints, few synthetic systems, pos

251 38]annulenoid oxidized form display residual macrocyclic ring currents.

252 Translation of a macrocyclic ring from one station to another on a molecu

253 e pathway must involve chelation, amidation, macrocyclic ring reduction, lactamization and carbocycli

254 The effect of macrocyclic ring size on the reaction rate of oxidative

255 r sulfonic (2) or carboxylic acids (3, 4) as macrocyclic ring substituents: the aminocaproate derivat

256 14-membered ring stapled peptide by means of macrocyclic ring-closing metathesis.

257 controlled E-selective cross-metathesis and macrocyclic ring-closing reactions, where E-butene serve

258 ialkyl nitroxide function mounted within the macrocyclic ring.

259 er-Wadsworth-Emmons olefination to forge the macrocyclic ring.

260 ry covering each position along thiocillin's macrocyclic ring.

261 he versatile ketone functionality within the macrocyclic ring.

262 ides tethered to chiral sulfoxide-containing macrocyclic rings.

263 The synthesis of a macrocyclic Ru carbene catalyst for selective cross alke

264 the Asn and Ala positions of a reported AGRP macrocyclic scaffold (c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro

265 different charge-transfer states within one macrocyclic scaffold delivers up to five different optic

266 odifying the chemically complex, 23-membered macrocyclic scaffold of group A streptogramins, analogue

267 We designed a macrocyclic scaffold to mimic the spatial conformation o

268 ch results from the combination of the rigid macrocyclic scaffold with the bulky, yet conformationall

269 built on the stable 26-membered tetraamidic macrocyclic scaffold, whereas various alkyl and aryl ure

270 Constrained macrocyclic scaffolds are recognized as challenging synt

271 ples where small structural modifications to macrocyclic scaffolds change the conformational preferen

272 hat explain how orthologs can generate rigid macrocyclic scaffolds of different sizes.

273 by introducing chiral substituents onto the macrocyclic scaffolds.

274 ass of thiazole-containing, highly modified, macrocyclic secondary metabolites made from ribosomally

275 describe optimization of the imidazole-based macrocyclic series and our initial progress toward meeti

276 Efficient, elegant, and high-yielding (for macrocyclic species) synthetic routes to two novel alkyn

277 talation, highlighting the importance of the macrocyclic stabilization.

278 Here we present the chiral macrocyclic structure biotin-l-sulfoxide[6]uril as a hos

279 Computational modeling of thiocillin's macrocyclic structure revealed a striking requirement fo

280 sociated with ionicity, protein binding, and macrocyclic structure.

281 that the incorporation of photoswitches into macrocyclic structures is a particularly attractive solu

282 c motifs is the signature of TAMLs where the macrocyclic structures vary considerably.

283 Binding of anions using macrocyclic structures with a nonpolar interior using th

284 ically robust enough to be incorporated into macrocyclic structures, thereby significantly expanding

285 molecular chemists - with their expertise in macrocyclic synthesis and measuring supramolecular inter

286 reaction involving cyclopentadiene and these macrocyclic systems has been selected in order to unders

287 last five decades, these naturally occurring macrocyclic systems have emerged only recently as promis

288 - and dimethylated macrolactones, and 1-keto macrocyclic systems, as well as two N-substituted ixabep

289 on, and reactivity of porphyrins and related macrocyclic systems.

290 ociated with topologically planar conjugated macrocyclic systems.

291 The synthesis of macrocyclic targets ranging from tetrapeptides to the di

292 Use of a macrocyclic tetracarbene ligand, which is topologically

293 Nosiheptide, a member of the e series of macrocyclic thiopeptide natural products, contains a sid

294 ch is a noncovalent, wild-type EGFR sparing, macrocyclic TKI.

295 the expression of Nisin variants with novel macrocyclic topologies.

296 ) NS3/4A protease inhibitor based on a P1-P3 macrocyclic tripeptide motif is described.

297 aration of hybrid ionic materials comprising macrocyclic triradical trianions with spin-frustrated gr

298 acologic stressor, GBCA molecular structure (macrocyclic vs linear GBCA: multivariable odds ratio, 0.

299 Only macrocyclic walker-track conjugates are efficiently hydr

300 In this work, a series of heptadentate macrocyclic YbDO3A-trisamide complexes with delta-chiral