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1 iers, the mobility of which is challenged by macromolecular crowding.
2 ither by a chaperone such as EF1A or through macromolecular crowding.
3 cessivity are not upregulated or hindered by macromolecular crowding.
4 three environmental variables: pH, salt, and macromolecular crowding.
5 tes are nearly equally adversely affected by macromolecular crowding.
6 h osmolality, presumably as a consequence of macromolecular crowding.
7 trates and protect them from the problems of macromolecular crowding.
8 iscosity increase, compatible with increased macromolecular crowding.
9 dies reveal that SED1 is highly sensitive to macromolecular crowding.
10  biomass to control the level of cytoplasmic macromolecular crowding.
11 response to changes in osmolarity that alter macromolecular crowding.
12 sing molecular weight in a manner typical of macromolecular crowding.
13 h influence transcriptional activity through macromolecular crowding.
14 condensates was also modulated by changes in macromolecular crowding.
15  water but otherwise not further hindered by macromolecular crowding.
16 al cell and at the high viscosity imposed by macromolecular crowding.
17  our understanding of the functional role of macromolecular crowding.
18 arious macromolecules, a phenomenon known as macromolecular crowding.
19 f the brain that have limited solvent due to macromolecular crowding.
20 ing both theory and experiment to studies of macromolecular crowding.
21 vesting efficiency of photosystem (PS) II on macromolecular crowding.
22 rnatively as the "depletion interaction" or "macromolecular crowding."
23         Herein, we assessed the influence of macromolecular crowding, a biophysical phenomenon that r
24                    However, it is known that macromolecular crowding, a key feature in natural cells,
25 Although it was previously demonstrated that macromolecular crowding affects association of RNAP to D
26                                              Macromolecular crowding affects most chemical equilibria
27                                        While macromolecular crowding affects multiple cellular proces
28                         Theory predicts that macromolecular crowding affects protein behavior, but ex
29                        The results show that macromolecular crowding affects protein-folding dynamics
30                                              Macromolecular crowding affects the activity of proteins
31  state of gp45 is, however, increased by the macromolecular crowding agent polyethylene glycol.
32 resence of 220 mg/mL dextran 70, a synthetic macromolecular crowding agent that occupies space but do
33 , we investigated the effects of a synthetic macromolecular crowding agent, dextran 20, on the folded
34 ClpB in the absence and presence of an inert macromolecular crowding agent.
35  presence of high concentrations of an inert macromolecular crowding agent.
36                                We introduced macromolecular crowding agents into reconstituted fusion
37  solutions containing high concentrations of macromolecular crowding agents would give new insights i
38 lding speed for apoazurin in the presence of macromolecular crowding agents, a result that points to
39 g reaction is carried out in the presence of macromolecular crowding agents, such as Ficoll and dextr
40 ein, apoflavodoxin, in the presence of inert macromolecular crowding agents, using in silico and in v
41 glycosaminoglycans or high concentrations of macromolecular crowding agents.
42 nscript length and was greatly stimulated by macromolecular crowding agents.
43 in machinery is sensitive to the presence of macromolecular crowding agents.
44 nd on the nanoscale organization assumed for macromolecular crowding agents.
45 es fundamental differences between small and macromolecular crowding agents.
46 n with FIH in the presence of cell lysate or macromolecular crowding agents.
47 unfolded-state compaction in the presence of macromolecular crowding along with its energetic and kin
48 tro results obtained on isolated mRNAs, both macromolecular crowding and a high ionic strength favor
49 ss density (CMD), which is also a measure of macromolecular crowding and concentrations of all protei
50                       These factors might be macromolecular crowding and excluded volume effects faci
51 lytes via specific transporters both reduces macromolecular crowding and ionic strength, thus leading
52       The encapsulation results suggest that macromolecular crowding and molecular confinement are ac
53 perimental system for testing the effects of macromolecular crowding and molecular confinement on pro
54                     Here, we discovered that macromolecular crowding and reducing agents increase ove
55  triggers global transcriptional repression, macromolecular crowding and remodelling of nuclear conde
56 radict predictions from accepted theories of macromolecular crowding and show that cosolutes commonly
57 e of amyloidogenesis may be affected by both macromolecular crowding and spatial heterogeneity (e.g.
58 reviously unidentified spatial regulation of macromolecular crowding and spatially distinct roles for
59 ents can critically influence the outcome of macromolecular crowding and that the structure of the am
60 ossibly enabling cellular cargos to overcome macromolecular crowding and to navigate obstacles along
61                           In vivo studies of macromolecular crowding and water dynamics are needed to
62 y cooperative process, strongly dependent on macromolecular crowding, and involves back-to-back stack
63 stingly, the flexibility is also hindered by macromolecular crowding, and NNTTR formation is strongly
64 fic physical properties affecting diffusion, macromolecular crowding, and reaction rates.
65    Physicochemical properties such as pH and macromolecular crowding are essential to all molecular p
66      Although the excluded-volume effects of macromolecular crowding are expected to cause compaction
67 mplicating the commonly overlooked aspect of macromolecular crowding as a possible factor in the etio
68        We identify the redox environment and macromolecular crowding as key modulatory factors.
69                In conclusion, we show that a macromolecular crowding-based biochemical model can be u
70 s on the available volume can be affected by macromolecular crowding, but the effects of crowding in
71 mimic intracellular compartmentalization and macromolecular crowding by partitioning RNA in an aqueou
72  scattering was used to study the effects of macromolecular crowding by two globular proteins, i.e.,
73                                              Macromolecular crowding can alter the structure and func
74 heir native intracellular environments where macromolecular crowding can drastically change reaction
75 te if combined application of ultrasound and macromolecular crowding can improve efficiency of MR.
76              Theoretical models predict that macromolecular crowding can increase protein folding sta
77                    Here, we demonstrate that macromolecular crowding can increase the robustness of g
78 can be inferred from their observations that macromolecular crowding can lead to robustness in gene e
79  ligands of different sizes (actin and ATP), macromolecular crowding can modulate the kinetics of ind
80 , ligand affinity, switching free energy and macromolecular crowding collectively control riboswitch
81                                              Macromolecular crowding conditions accelerate reactions
82            Here we have investigated whether macromolecular crowding conditions are able to promote h
83 acterium tuberculosis (Mtb) DNA gyrase under macromolecular crowding conditions by incorporating PEGs
84 s of weakly basic small molecule drugs under macromolecular crowding conditions where other nonspecif
85 ciency, we varied the salt concentration and macromolecular crowding conditions.
86  protein domain, intracellular viscosity and macromolecular crowding dictate its in vivo behavior.
87                                    Increased macromolecular crowding does not activate OpuA but acts
88 periment and computer simulation to show how macromolecular crowding dramatically affects the structu
89 s at different fixed temperatures showed the macromolecular crowding effect to be temperature-indepen
90 ation of polyvalent binding and the enhanced macromolecular crowding effect using nanoparticles.
91                                              Macromolecular crowding effects may be a tool for the ma
92                                  To quantify macromolecular crowding effects on protein folding mecha
93                                    Herein, a macromolecular crowding electrolyte (MCE40) is prepared
94                    Here, we demonstrate that macromolecular crowding enhances the rate of late initia
95       Recent results support the notion that macromolecular 'crowding' enhances protein aggregation,
96 ing condition, the excluded volume effect of macromolecular crowding favors aggregation, whereas incr
97                          Most theories about macromolecular crowding focus on two ideas: the macromol
98  a qualitatively different dependence on the macromolecular crowding for high and low values of the r
99                               We studied how macromolecular crowding guides protein between different
100                                              Macromolecular crowding has a profound effect upon bioch
101                                              Macromolecular crowding has long been known to significa
102                 This study demonstrates that macromolecular crowding has structural effects on the fo
103 al implications, few experimental studies of macromolecular crowding have been reported.
104                                   Studies of macromolecular crowding have shown its important effects
105 s establish that the matrix solvent exhibits macromolecular crowding in functional and dysfunctional
106 o the ever-growing interest in understanding macromolecular crowding in living cells and their effect
107 n 0s, Aqp0a and Aqp0b, alter water state and macromolecular crowding in living lenses.
108 nd computational modeling, we also show that macromolecular crowding in the cell increases the signal
109 mbles a fractal structure with its origin in macromolecular crowding in the cell membrane.
110 n important factor in limiting the degree of macromolecular crowding in the cell.
111 e roles of cytoplasmic osmolytes, water, and macromolecular crowding in the growth of osmotically str
112                                              Macromolecular crowding in the lens is essential for nor
113 n be regulated jointly by the local level of macromolecular crowding in the nucleus, together with th
114             We seek to elucidate the role of macromolecular crowding in transcription and translation
115                 Our results demonstrate that macromolecular crowding in two dimensions can play a sig
116  structures because milder water deficit and macromolecular crowding induce high alpha-helix levels i
117 hese findings have profound implications for macromolecular crowding inside cells.
118                                              Macromolecular crowding intensifies oxidative modificati
119                                              Macromolecular crowding is a critical parameter affectin
120                                 Importantly, macromolecular crowding is able to partially rescue G4Q
121                                              Macromolecular crowding is commonly understood in terms
122                                              Macromolecular crowding is crucial for cellular homeosta
123                                              Macromolecular crowding is expected to have a significan
124                                              Macromolecular crowding is known to profoundly influence
125                                              Macromolecular crowding is one of the key characteristic
126             This volume exclusion because of macromolecular crowding is predicted to affect both equi
127 ere, we present an unexpected discovery that macromolecular crowding is required for reconstituting t
128 er the mitochondrial matrix solvent exhibits macromolecular crowding is still unclear.
129                                              Macromolecular crowding is the usual condition of cells.
130                              With increasing macromolecular crowding levels, the precision of particl
131 in CLYs was sensitive to solvent quality and macromolecular crowding making them potent environmental
132                                              Macromolecular crowding, manifested by high concentratio
133                               To explore how macromolecular crowding may influence cellular protein f
134                  Our results demonstrate how macromolecular crowding may influence protein folding by
135 id create a physicochemical condition called macromolecular crowding (MMC).
136 asound, biophysical properties of tissue and macromolecular crowding of insonated zone of tissue are
137 in mislocalization, and demonstrates how the macromolecular crowding of RPBs at the ribosome exit sit
138 s generally assumed to be anomalous due high macromolecular crowding of the milieu.
139 the importance of approaching the effects of macromolecular crowding on a case-by-case basis.
140                          Thus, the effect of macromolecular crowding on activity and structure need t
141                  We addressed the effects of macromolecular crowding on alpha-synuclein by combining
142 mental question we investigate the effect of macromolecular crowding on cell metabolism.
143 s attention has been given to the effects of macromolecular crowding on cell physiology.
144  the present study we analyzed the effect of macromolecular crowding on fibrillation of four proteins
145                      To study the effects of macromolecular crowding on folding thermodynamics and ki
146 s to quantify the spatial heterogeneities of macromolecular crowding on live cell surfaces.
147               We have studied the effects of macromolecular crowding on protein folding kinetics by s
148                 We investigate the effect of macromolecular crowding on protein folding, using purely
149 esidue-level interrogation of the effects of macromolecular crowding on protein stability.
150 s for the effects of spatial confinement and macromolecular crowding on protein stability.
151                       However, the effect of macromolecular crowding on protein structure is poorly u
152 udy the effects of cellular architecture and macromolecular crowding on signal transduction in Escher
153                Here we analyze the effect of macromolecular crowding on structure and function of the
154           To investigate the consequences of macromolecular crowding on the behavior of a globular pr
155                                The effect of macromolecular crowding on the binding of ligands to a r
156 However, little is known about the effect of macromolecular crowding on the interactions of IDPs with
157 rom effects of preferential interactions and macromolecular crowding on the membrane or on ProP.
158                      The observed effects of macromolecular crowding on the myosin-ligand interaction
159                                The effect of macromolecular crowding on the rates of association reac
160 ive transition-state ensemble, the effect of macromolecular crowding on the relative stability betwee
161 l-angle scattering to measure the effects of macromolecular crowding on the size of a protein complex
162 s works have reported significant effects of macromolecular crowding on the structure and behavior of
163 he effect of intermolecular excluded volume (macromolecular crowding) on protein stability and confor
164                                              Macromolecular crowding opens new avenues for a more rat
165 pic, excluded-volume effect variously called macromolecular crowding or depletion attraction.
166 to a dead-end aggregate, rather than through macromolecular crowding or diffusion-limitations.
167 on dependence and sensitivity to starvation, macromolecular crowding, or 1,6-hexanediol treatment.
168                                              Macromolecular crowding ought to stabilize folded forms
169 ity rather than cellular stress responses or macromolecular crowding per se.
170       Although it is still underappreciated, macromolecular crowding plays a critical role in life as
171                                Consequently, macromolecular crowding plays a major role in determinin
172                   In vitro studies show that macromolecular crowding, rather than changes in monolaye
173                        Our results show that macromolecular crowding reduces noise (as measured by th
174 indicating that an age-dependent increase in macromolecular crowding resulting from water loss may be
175                                      Using a macromolecular crowding sensor optimized for long-term F
176                                 Accordingly, macromolecular crowding should constitute an integral el
177 lisecond time resolution under conditions of macromolecular crowding similar to those within cells.
178        Our data reinforce the assertion that macromolecular crowding stabilizes the protein by destab
179 d HIV-1 CA-NC complexes is not due solely to macromolecular crowding, suggesting the presence of spec
180  vitro system using TGFbeta1 stimulation and macromolecular crowding techniques to evaluate the mecha
181                                   Models for macromolecular crowding tend to focus on the steric effe
182 robes provides more detailed readouts on the macromolecular crowding than a single sensor.
183 o-collective hydration transition induced by macromolecular crowding that slows the hydration dynamic
184                 However, the contribution of macromolecular crowding to receptor retention remains po
185                              Here we examine macromolecular crowding using the replication system of
186    Specifically, we demonstrate that, during macromolecular crowding, viscosity dominates over the ex
187                                 Furthermore, macromolecular crowding was used in vitro to expand the
188          At high osmolarity, the increase in macromolecular crowding which accompanies the reduction
189 laminonaphthalene (ACDAN)] to visualize lens macromolecular crowding with in vivo studies of aquapori
190 hat the random network architecture resisted macromolecular crowding with polyethylene glycol and blo
191 , we connect physicochemical homeostasis and macromolecular crowding with the formation and function
192 an might be anticipated considering the high macromolecular crowding within the cell.

 
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