ライフサイエンスコーパス: macropinocytosis

1 entry gate to within the cells' cytoplasm is macropinocytosis.

2 is dependent on CD47, and is facilitated by macropinocytosis.

3 and catabolism of extracellular protein via macropinocytosis.

4 ent tumor cells, and blocked KRAS-stimulated macropinocytosis.

5 rocess associated with membrane ruffling and macropinocytosis.

6 tor amiloride, suggesting that PepB2 invokes macropinocytosis.

7 ance of DF into ECs occurs primarily through macropinocytosis.

8 ed whether THY-1 has a role in HCMV entry by macropinocytosis.

9 arity, lamellipodial assembly, ruffling, and macropinocytosis.

10 influx through transporters, receptors, and macropinocytosis.

11 membranous intracellular pH occurring during macropinocytosis.

12 ase substrate) in KSHV entry into HMVEC-d by macropinocytosis.

13 in vivotarget cells, by lipid raft-dependent macropinocytosis.

14 in cell types, contributes to virus entry by macropinocytosis.

15 regates are internalized into AC16 cells via macropinocytosis.

16 er changes in cell morphology, and increased macropinocytosis.

17 C1 by amino acids, but not glucose, requires macropinocytosis.

18 hrin- and caveolar-dependent endocytosis and macropinocytosis.

19 ytic mechanism related to, but distinct from macropinocytosis.

20 bsequent cytoskeletal cross talk during KSHV macropinocytosis.

21 of HMPV by MDDC was found to be primarily by macropinocytosis.

22 r its efficient entry into HMVEC-d cells via macropinocytosis.

23 or loss of PTEN) have been shown to increase macropinocytosis.

24 to stimulate host actin remodeling and toxin macropinocytosis.

25 the formation of ruffles, and the process of macropinocytosis.

26 lls by a process that most closely resembles macropinocytosis.

27 tially reduced by amiloride, an inhibitor of macropinocytosis.

28 ion in actin turnover occurring during toxin macropinocytosis.

29 (PI) 3-kinase activity, leading to receptor macropinocytosis.

30 o probe their environment by phagocytosis or macropinocytosis.

31 signaling as a result of increased receptor macropinocytosis.

32 T protein and enters via c-Cbl-bleb-mediated macropinocytosis.

33 ruffles, where they are internalized through macropinocytosis.

34 ted endocytosis, but not for phagocytosis or macropinocytosis.

35 of dextran was used to quantify the rate of macropinocytosis.

36 asma membrane to drive RAC1 GTPase-dependent macropinocytosis.

37 for the stimulation of membrane ruffling and macropinocytosis.

38 RC1/mTORC2 as the underpinning mechanism for macropinocytosis.

39 g their cell entry through receptor-mediated macropinocytosis.

40 aired fMLF-directed chemotaxis, and abnormal macropinocytosis.

41 tumors was consistent with the induction of macropinocytosis.

42 and clathrin-mediated endocytosis, alongside macropinocytosis.

43 se) as an essential regulator of RAS-induced macropinocytosis.

44 tor cells in which it establishes latency by macropinocytosis.

45 t endocytic pathway which is consistent with macropinocytosis.

46 l proliferation that is supported by protein macropinocytosis.

47 in via a fluid-phase uptake mechanism termed macropinocytosis(1).

48 The RAS oncoprotein drives elevated macropinocytosis, a metabolic process essential for canc

49 e of large amounts of extracellular fluid by macropinocytosis, a nonreceptor-mediated actin-driven pr

50 l as a new role for nucleolin in stimulating macropinocytosis, a process with potential applications

51 We conclude that BMP-induced macropinocytosis acts as a BMPR homeostatic mechanism to

52 Macropinocytosis acts as the major internalization route

53 rived cancer cells in a mechanism similar to macropinocytosis, albeit without the previously describe

54 s dominated by slow endocytic processing via macropinocytosis, although some caveolar endocytosis was

55 intestinal epithelial cells stimulates toxin macropinocytosis, an actin-dependent endocytic pathway.

56 SDC1 at the cell surface-where it regulates macropinocytosis, an essential metabolic pathway that fu

57 a combination of NaCl hypertonicity-induced macropinocytosis and a transduction compound (propanebet

58 Genes for macropinocytosis and actin/cytoskeleton rearrangement we

59 ary artery endothelial cells (caECs) through macropinocytosis and acts directly on mouse and human co

60 wth by downregulating nutrient transporters, macropinocytosis and autophagy still provide cancer cell

61 We also determined that macropinocytosis and caveolar endocytosis, both establis

62 entify SLIT2 as a physiological inhibitor of macropinocytosis and challenge the conventional notion t

63 1-null cells exhibited pronounced defects in macropinocytosis and chemotactic aggregation that were r

64 Inhibitors and RNAi specific for macropinocytosis and clathrin-mediated endocytosis had n

65 urthermore, ssRNA-TNP uptake is dependent on macropinocytosis and clathrin-mediated endocytosis pathw

66 soluble factors are sufficient to stimulate macropinocytosis and deliver toxin into enterocytes in v

67 We further identify albumin-associated macropinocytosis and endocytosis as an ApoE-independent

68 Inhibitors of macropinocytosis and endocytosis reduced latent viral ge

69 ized electron microscopy to observe entry by macropinocytosis and endocytosis, providing additional v

70 er cell line models used to study latency by macropinocytosis and endocytosis.

71 the widely used axenic mutants, show little macropinocytosis and few large PIP(3) patches, but migra

72 in DU145 cells but was necessary for induced macropinocytosis and FL-AS1411 uptake at later times.

73 lorectal cancer cells displayed constitutive macropinocytosis and increased extracellular protein deg

74 Thus PIP(3) promotes macropinocytosis and interferes with pseudopod orientati

75 ated internalization and fusion, and through macropinocytosis and lipid raft-dependent endocytosis.

76 Furthermore, macropinocytosis and lipid raft-mediated were shown here

77 vironments by recovering amino acids through macropinocytosis and lysosomal catabolism of extracellul

78 are dispensable for growth-factor-stimulated macropinocytosis and lysosomal catabolism of extracellul

79 ls in a low free-glutamine environment, when macropinocytosis and lysosomal degradation of extracellu

80 n of UBAP2 is critical for the regulation of macropinocytosis and maintaining the levels of activated

81 ng severe hemorrhagic fever, enters cells by macropinocytosis and membrane fusion in a late endosomal

82 d in the context of interconnections between macropinocytosis and metabolic signaling.

83 34(+) hematopoietic progenitor cells through macropinocytosis and our comparison to viral entry into

84 Macropinocytosis and phagocytosis are evolutionarily con

85 Our results link NF1 with macropinocytosis and phagocytosis for the first time, an

86 Regulation of Ag uptake via macropinocytosis and phagocytosis has been extensively s

87 c-Cbl knockdown blocked the macropinocytosis and receptor translocation and diverted

88 ct the EGFR signaling involved in E-cadherin macropinocytosis and recycling and regulate AJ formation

89 vented JAM-A relocalization, suggesting that macropinocytosis and recycling to the membrane surface o

90 by aggregated Tau that enters cells through macropinocytosis and seeds the assembly of endogenous Ta

91 that immature DCs efficiently take up Ag by macropinocytosis and store the internalized material in

92 nvolves uptake of extracellular proteins via macropinocytosis and subsequent lysosomal degradation of

93 role of mTORC2 in regulating tumor growth by macropinocytosis and suggest that dual inhibitors could

94 rane association of ESCRT protein Hrs during macropinocytosis and suggest that KSHV entry requires bo

95 ino acids coincides with increased levels of macropinocytosis and that the scarcity of glutamine uniq

96 cellular entry, the virus is internalized by macropinocytosis and trafficked through endosomes until

97 edge retraction involves ephrinB1-dependent macropinocytosis and trans-endocytosis.

98 producing strains, can stimulate Shiga toxin macropinocytosis and transcellular transcytosis alters c

99 as a potential therapeutic target to inhibit macropinocytosis and tumor growth in activated KRAS-driv

100 alization mechanisms with characteristics of macropinocytosis and, assisted by Golgi fragmentation, i

101 the comparative mechanisms of CPP uptake and macropinocytosis, and accentuate the significant methodo

102 erturbations, such as blebs, observed during macropinocytosis, and activation of the signal molecules

103 elective uptake of Plekho1 siRNA, mainly via macropinocytosis, and boosted in vivo osteoblast-specifi

104 ypes of endocytosis, including phagocytosis, macropinocytosis, and clathrin-independent endocytosis.

105 , lamellipodial assembly, membrane ruffling, macropinocytosis, and collective cell migration.

106 es released from dying cells and taken up by macropinocytosis, and exosomes secreted from living cell

107 differentiation, growth, protein stability, macropinocytosis, and nutrient acquisition in lysosomes.

108 d influx of extracellular fluid, a marker of macropinocytosis, and this increased fluid uptake was in

109 Here we show that monocytes engulf CPPs via macropinocytosis, and this process is strictly dependent

110 s the levels of activated KRAS, and inhibits macropinocytosis, and tumor growth in vivo.

111 facilitates assembly of signaling molecules, macropinocytosis, and virus entry.

112 Phagocytosis and macropinocytosis are Ras-regulated and actin-driven proc

113 These results identify macropinocytosis as a mechanism by which cancer cells su

114 esults showing that influenza virus utilizes macropinocytosis as an alternate entry pathway.

115 This study reveals macropinocytosis as an important process utilized by chR

116 find that filamentous influenza viruses use macropinocytosis as the primary entry mechanism.

117 ellular roles, notably in growth control and macropinocytosis as well as cell motility.

118 EphA2 shRNA ablated macropinocytosis-associated signaling events, virus inte

119 ude that HCMV virions enter CD34(+) cells by macropinocytosis but fail to fully uncoat or disassemble

120 atment resulted in decreased ZEBOV entry via macropinocytosis but had no effect on the clathrin-depen

121 n of the Rac1 and cdc42 GTPases that control macropinocytosis but not activation of the phosphoinosit

122 ic Ras proteins have been shown to stimulate macropinocytosis but the functional contribution of this

123 trastructurally, CendR endocytosis resembles macropinocytosis, but is mechanistically different.

124 and inflammatory stimuli are known to induce macropinocytosis, but its endogenous inhibitors have rem

125 s via both dynamin-dependent endocytosis and macropinocytosis, but likely not relying on taurine tran

126 T cell activation by DCs, selectively limits macropinocytosis, but not receptor-mediated phagocytosis

127 Blocking macropinocytosis by inhibition of PI 3-kinase prevented

128 olecular steps that mediate the induction of macropinocytosis by oncogenic RAS.

129 Stimulation of macropinocytosis by platelet-derived growth factor coord

130 Conversely, increasing macropinocytosis by Rabankyrin-5 overexpression was suff

131 e plasma membrane enhances cell motility and macropinocytosis, by which junction-associated E-cadheri

132 Here, we demonstrate that protein macropinocytosis can also serve as an essential amino ac

133 In particular, macropinocytosis can be a nutrient source for pancreatic

134 acking CARMIL1 have defects in lamellipodia, macropinocytosis, cell migration, and Rac1 activation.

135 olar/lipid raft-mediated endocytosis but not macropinocytosis, clathrin-mediated endocytosis, or glyc

136 Because the endocytic process of macropinocytosis concentrates extracellular solutes into

137 Selective, genetic inhibition of macropinocytosis confirms that necrocytosis both support

138 ti-inflammatory macrophages perform vigorous macropinocytosis constitutively, while proinflammatory c

139 iding a possible mechanism for GILZ-mediated macropinocytosis control.

140 Macropinocytosis coordinates non-specific uptake of macr

141 ion, we find that intratumoral inhibition of macropinocytosis decreases amino acid levels.

142 is coli (APC) or Axin dramatically increased macropinocytosis, defined by incorporation of the high m

143 Macropinocytosis delivered small, fluorescent fluid-phas

144 t BMP ligand Glass bottom boat (Gbb) induces macropinocytosis dependent on Rac1/SCAR signaling, Abl-m

145 We further demonstrate that macropinocytosis depends on MKK4 activated by elevated r

146 of extracellular material by phagocytosis or macropinocytosis depends on the ability of cells to gene

147 Mechanistically, this stimulation of macropinocytosis depends on the nutrient stress-induced

148 results reveal that oncogenic activation of macropinocytosis determines BCG uptake by bladder cancer

149 rate contextual metabolic inputs to regulate macropinocytosis, dialing up or down this uptake pathway

150 ernal routes and identify a new function for macropinocytosis during growth factor-induced cell migra

151 tion was associated with internalization via macropinocytosis during paracellular route opening.

152 try: use of cell surface attachment factors, macropinocytosis, endosomal receptors, and low pH to tri

153 d growth factor beta-receptor (PDGFRbeta) by macropinocytosis, enhancing its signaling activity and i

154 ntracellular macromolecular synthesis during macropinocytosis, entosis, and phagocytosis.

155 In addition, we showed that phagocytosis or macropinocytosis, flotillin-1, and GRAF1 are not require

156 Cells take up Ebola virus by macropinocytosis, followed by trafficking through endoso

157 pits, and DN PAK-1, an obligate mediator of macropinocytosis, had no significant impact on RVFV infe

158 Assessing macropinocytosis has been challenging in the past becaus

159 f macromolecules and cellular debris through macropinocytosis has emerged as an important nutrient ac

160 Macropinocytosis has emerged as an important nutrient-sc

161 Among the endocytic routes, macropinocytosis has unique characteristics for engulfin

162 RAS-transformation (activation) that lead to macropinocytosis have not been identified.

163 We tested whether inhibition of macropinocytosis impacted rAAV transduction of HeLa cell

164 I3K, and Pak1 kinase, which are critical for macropinocytosis, impaired HCMV infection.

165 The inhibition of macropinocytosis impairs entry, thereby diminishing late

166 can induce structural changes reminiscent of macropinocytosis in actin-encapsulated giant vesicles wi

167 hanism of uptake was different, occurring by macropinocytosis in cancer cells, but by a nonmacropinoc

168 or visualizing and quantifying the extent of macropinocytosis in cells both in culture and growing in

169 identify GILZ as an endogenous inhibitor of macropinocytosis in DCs, the action of which contributes

170 ntly, we have revealed a functional role for macropinocytosis in fueling cancer cell growth through t

171 isolated mitochondria being internalised by macropinocytosis in HOS cells.

172 w report that Akt3 constitutively suppresses macropinocytosis in macrophages through a novel WNK1/SGK

173 hat Akt3 is a specific negative regulator of macropinocytosis in macrophages.

174 Our results thus implicate a function of macropinocytosis in mammalian cell growth beyond Ras-tra

175 ein 2), regulates the activation of KRAS and macropinocytosis in pancreatic cancer.

176 ding cytokines, chemokines, and LPS, induced macropinocytosis in proinflammatory cells.

177 xtracellular proteins being degraded through macropinocytosis in quantities necessary to meet glutami

178 SLIT2 also inhibits macropinocytosis in RAS-transformed cancer cells, thereb

179 Accordingly, blockage of EGFR signaling or macropinocytosis in reggie-deficient cells restores norm

180 ibitors OSI-027 and PP242 cause catastrophic macropinocytosis in rhabdomyosarcoma (RMS) cells and can

181 , we directly observe protein catabolism and macropinocytosis in situ by pancreatic cancer cells, but

182 Mechanistically, macropinocytosis in T cells provides access of extracell

183 sin II or treatment of phorbol ester induces macropinocytosis in the axons and elicits growth cone co

184 rt that Sonic hedgehog (Shh) protein induces macropinocytosis in the axons through activation of a no

185 These results suggest a role for macropinocytosis in the process by which EV1 enters pola

186 a unique framework for strategies to target macropinocytosis in the treatment of cancer.

187 he activation of Pak, controls the extent of macropinocytosis in these cells.

188 We report that SLIT2 inhibits macropinocytosis in vitro and in vivo by inducing cytosk

189 on requires factors commonly associated with macropinocytosis, including amiloride-sensitive Na(+)/H(

190 tivation of signaling molecules critical for macropinocytosis, including phosphatidylinositol 3-kinas

191 d for initial cellular entry of LNPs through macropinocytosis, including proton pumps, mTOR and cathe

192 Macropinocytosis induction is rapid and independent of p

193 , we characterize in detail the mechanism of macropinocytosis induction.

194 ells, and inhibitors that are known to block macropinocytosis inhibited both dextran uptake and ZEBOV

195 Microscopy revealed that macropinocytosis inhibition correlated with expedited nu

196 We found that macropinocytosis inhibitor cytochalasin D blocked rAAV t

197 Similar results were obtained with another macropinocytosis inhibitor, 5-(N-ethyl-N-isopropyl) amil

198 Treatment with a macropinocytosis inhibitor, 5-(N-ethyl-N-isopropyl)amilo

199 ) proceeded slowly and could be blocked by a macropinocytosis inhibitor, entry of wild-type AD169 exp

200 y reduced SHFV entry efficiency, whereas the macropinocytosis inhibitors EIPA, blebbistatin, and wort

201 ce the ability of HMPV to be internalized by macropinocytosis into human dendritic cells (DC).

202 EAEC) O104:H4 robustly stimulate Shiga toxin macropinocytosis into intestinal epithelial cells.

203 Since macropinocytosis involves integrin signaling, is PI3K/Ak

204 mediated transduction occurs via fluid-phase macropinocytosis involving an intracellular pH drop to a

205 Macropinocytosis is a fundamental mechanism that allows

206 Macropinocytosis is a highly conserved endocytic process

207 Our results suggest that macropinocytosis is a potential mechanism of intracellul

208 Macropinocytosis is a type of poorly characterized fluid

209 Macropinocytosis is an actin-driven form of clathrin-ind

210 Scavenging of extracellular protein via macropinocytosis is an alternative to monomeric amino ac

211 Macropinocytosis is an ancient mechanism that allows cel

212 Macropinocytosis is an evolutionarily-conserved, large-s

213 Macropinocytosis is an important nutrient-scavenging pat

214 In pancreatic cancer, macropinocytosis is driven by oncogenic Ras signaling an

215 Macropinocytosis is essential for myeloid cells to surve

216 Toxin macropinocytosis is independent of EHEC type 3 secretion

217 (HMVEC-d), natural in vivo target cells, via macropinocytosis is initiated through a multistep proces

218 Furthermore, we reveal that macropinocytosis is likely a major endocytic pathway in

219 ted proteins into lysosomes, its function in macropinocytosis is not known.

220 Consistent with this hypothesis, active macropinocytosis is observed in primary human PDAC speci

221 Macropinocytosis is the major entry pathway of KSHV in h

222 Macropinocytosis is upregulated in oncogene-expressing c

223 Although macropinocytosis is used by both epithelial and endothel

224 Thus, the observation that inhibiting macropinocytosis leads to cell-specific enhancement or i

225 d on actin remodeling and Pak1, suggesting a macropinocytosis-like cell entry pathway.

226 al changes as well as fluid uptake through a macropinocytosis-like pathway as chemical inhibition of

227 rin-dependent endocytic pathway to a slower, macropinocytosis-like pathway.

228 iated chemokine endocytosis occurs through a macropinocytosis-like process in endothelial cells and c

229 , we found that HCMV enters these cells by a macropinocytosis-like process.

230 efficient entry into certain cell types by a macropinocytosis-like process.

231 nsported to metastatic tumor cells through a macropinocytosis-lysosome pathway, endowing tumor cells

232 loride or wortmannin blocked the increase in macropinocytosis mediated by CTR2 knockdown.

233 Macropinocytosis mediates the uptake of antigens and of

234 key cellular processes such as phagocytosis, macropinocytosis, membrane trafficking, motility, autoph

235 P27 prevents virus accumulation by inducing macropinocytosis (MPC).

236 show that consuming necrotic cell debris via macropinocytosis (necrocytosis) offers additional anabol

237 onventional notion that signals that enhance macropinocytosis negatively regulate cell migration, and

238 PDGF-BB and epidermal growth factor promoted macropinocytosis of both receptors and increased their a

239 Enhanced macropinocytosis of CPPs results in increased lysosomal

240 uffled border also need to be recycled after macropinocytosis of digested bone materials.

241 s of Yap or Taz were sufficient to stimulate macropinocytosis of extracellular protein.

242 Recently, Ras-induced macropinocytosis of extracellular proteins was shown to

243 ics to the cytosolic signaling events during macropinocytosis of KSHV.

244 hange is an essential event required for the macropinocytosis of KSHV.

245 ignals in LRs, leading to bleb formation and macropinocytosis of KSHV.

246 f Rac/RhoG was responsible for the deficient macropinocytosis of proinflammatory macrophages, as sugg

247 sts, and endothelial cells, likely through a macropinocytosis pathway.

248 fluid markers, through a receptor-dependent macropinocytosis pathway.

249 ay that shares features with canonical viral macropinocytosis, phagocytosis, and mechanotransduction.

250 cells with AS1411 caused hyperstimulation of macropinocytosis, provoking an increase in its own uptak

251 Key regulators of macropinocytosis (Rabankyrin and CtBP) control BMPR traf

252 es, engulfment is rare and may occur through macropinocytosis rather than directed engulfment.

253 ake of BCG by bladder cancer cells occurs by macropinocytosis rather than phagocytosis.

254 ons associated with CDR formation, including macropinocytosis, receptor internalization, and cell mig

255 DCs use constitutive macropinocytosis, receptor-mediated endocytosis, and pha

256 However, whether macropinocytosis regulates the expansion of non-transfor

257 only inhibited in A431 cells depleted of the macropinocytosis regulator Pak-1, but experimental varia

258 (GP-wt), GP-F88A-mediated entry occurs via a macropinocytosis-related pathway and requires endosomal

259 Consistent with macropinocytosis representing an important route of nutr

260 cells by caveolin-dependent endocytosis and macropinocytosis, respectively.

261 Inhibition of macropinocytosis resulted in the distribution of viral c

262 Macropinocytosis seems to be the main route used by poly

263 Macropinocytosis serves as an internalization pathway fo

264 Pharmacological inhibition of macropinocytosis significantly reduced metastatic coloni

265 Uptake occurred by macropinocytosis, similar to the uptake of bacteria pass

266 influences metabolic phenotypes and whether macropinocytosis supports the maintenance of amino acid

267 Macropinocytosis supports the metabolic requirement of R

268 and abolishing the constitutive ruffling and macropinocytosis that characterize macrophages and immat

269 V-ATPase trafficking and nutrient supply by macropinocytosis that could be exploited to curtail the

270 at primary mouse and human T cells engage in macropinocytosis that increases in magnitude upon T cell

271 -dependent and -independent pathways such as macropinocytosis that mediate high-molecular-weight dext

272 ecent work identifying the key regulators of macropinocytosis that support tumor cell fitness in diff

273 and phosphoinositides involved in initiating macropinocytosis, the commitment to forming a macropinos

274 Macropinocytosis, the internalization of extracellular f

275 nstrate for the first time that Axl enhances macropinocytosis, thereby increasing productive ZEBOV en

276 Cs markedly down-regulate their capacity for macropinocytosis, they continue to capture, process, and

277 As) associated with serum albumin stimulated macropinocytosis through a pathway that involves FFA rec

278 We demonstrate macropinocytosis through the uptake of FITC-dextran and

279 M selectively accumulate in cancer cells via macropinocytosis to impede the dynamics of cytoskeletal

280 Cells use phagocytosis and macropinocytosis to internalise bulk material, which in

281 Cancers employ macropinocytosis to obtain nutrients to support their me

282 sly unveils a requirement for Rac1-dependent macropinocytosis to provide non-essential amino acids, i

283 links Abl and Rac1 GTPase signaling to BMPR macropinocytosis to restrain BMP-mediated synaptic devel

284 Here we show that Ras-transformed cells use macropinocytosis to transport extracellular protein into

285 cDDP in part through control of the rate of macropinocytosis via activation of Rac1 and cdc42.

286 19) report that glutamine deprivation boosts macropinocytosis via EGFR signaling induction, providing

287 Macropinocytosis was blocked by dominant-negative vacuol

288 PDGFRbeta macropinocytosis was both necessary and sufficient for e

289 Macropinocytosis was confirmed using specific inhibitors

290 nd that lipid raft-dependent endocytosis and macropinocytosis were major pathways involved in lipo-Ta

291 ntegrate signal pathways and productive KSHV macropinocytosis were unknown, we immunoprecipitated KSH

292 ry CD34(+) hematopoietic progenitor cells by macropinocytosis, where it establishes latency in part b

293 sm involves actin-driven lipid raft-mediated macropinocytosis, where particles primarily accumulate i

294 pper via a non-canonical mechanism involving macropinocytosis, which appears to be required to suppor

295 Each plays roles in mediating macropinocytosis, which has been shown to be important f

296 ncreasing the uptake of endocytic markers of macropinocytosis while decreasing those for clathrin- an

297 Inhibition of macropinocytosis with either amiloride or wortmannin blo

298 tivation of signaling pathways that activate macropinocytosis, with phosphoinositide 3-kinase inhibit

299 important pathway enabling cells to sustain macropinocytosis without bulk degradation of plasma memb

300 s a specialized form of endocytosis known as macropinocytosis, without affecting phagocytosis or clat